                               SEQUENCE LISTING

<110> BORRIELLO, FRANK
 
<120> COMPOSITIONS AND METHODS FOR IN VITRO ACTIVATION AND EXPANSION OF
      SERIAL KILLER T CELL POPULATIONS  AND PASSIVE IMMUNIZATION OF A 
      CANCER PATIENT WITH THE TUMOR CELL KILLING CELLS

<130> 128663-00320

<140>
<141>

<150> 16/660,442
<151> 2019-10-22

<150> 15/821,105
<151> 2017-11-22

<150> 62/425,424
<151> 2016-11-22

<160> 114   

<170> PatentIn version 3.5

<210> 1
<211> 399
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      membrane IgG-1 heavy chain 

<400> 1
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys 
                325                 330                 335     


Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr 
            340                 345                 350         


Ile Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val 
        355                 360                 365             


Thr Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys 
    370                 375                 380                 


Gln Thr Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
385                 390                 395                 


<210> 2
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      secreted IgG-1 heavy chain 

<400> 2
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 3
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      fragment secreted IgG-1 heavy chain 

<400> 3
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                165                 170                 175     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Pro Gly Lys 
    290                 295 


<210> 4
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region 

<400> 4
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 5
<211> 184
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mGM-CSF HLA derived TM and SHORTENED cytoplasmic domain 

<400> 5
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


Glu Leu Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly 
145                 150                 155                 160 


Leu Val Leu Leu Gly Ala Val Ile Thr Gly Ala Val Val Ala Ala Val 
                165                 170                 175     


Met Trp Arg Arg Lys Ser Ser Asp 
            180                 


<210> 6
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CD40L sequence

<400> 6
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 7
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      non-cleavable CD40L sequence

<400> 7
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Pro Arg Gly Glu Glu Asp Ser Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 8
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      TNF sequence

<400> 8
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210> 9
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CD40L piece 

<400> 9
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu 
            100                 105             


<210> 10
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      TNF piece 

<400> 10
Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
1               5                   10                  15      


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
            20                  25                  30          


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
        35                  40                  45              


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
    50                  55                  60                  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
65                  70                  75                  80  


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
                85                  90                  95      


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
            100                 105                 110         


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
        115                 120                 125             


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    130                 135                 140     


<210> 11
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mTNF-a 

<400> 11
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Ser Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Glu Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210> 12
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Constant Region 3 from IgG1

<400> 12
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser 
            100                 105                 110         


Cys 
    


<210> 13
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      native GM-CSF 

<400> 13
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 14
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Flt3L 

<400> 14
Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210> 15
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Kozak sequence 

<400> 15
gccgccrcca ugg                                                          13


<210> 16
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region E213Q 

<400> 16
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Gln Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 17
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region P221L 

<400> 17
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Leu Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 18
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region E224Q 

<400> 18
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Gln 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 19
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region Y226F 

<400> 19
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 20
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region D242N 

<400> 20
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asn Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 21
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region N245D 

<400> 21
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asp Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 22
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region T269A 

<400> 22
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 23
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region S314N 

<400> 23
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 24
<211> 376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region S314 del 

<400> 24
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375     


<210> 25
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG-3 heavy chain constant region F366Y 

<400> 25
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 26
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      TNF - VRSSSRTPSDKP del 

<400> 26
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Ala His Val 
65                  70                  75                  80  


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
                85                  90                  95      


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
            100                 105                 110         


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
        115                 120                 125             


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
    130                 135                 140                 


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
145                 150                 155                 160 


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
                165                 170                 175     


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
            180                 185                 190         


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
        195                 200                 205             


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215                 220     


<210> 27
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      TNF - FSFLIVAGATTLFCLLHFGVI del 

<400> 27
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu Ser Leu 
        35                  40                  45              


Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr Pro Ser 
    50                  55                  60                  


Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln 
65                  70                  75                  80  


Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val 
                85                  90                  95      


Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu 
            100                 105                 110         


Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His 
        115                 120                 125             


Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr 
    130                 135                 140                 


Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr 
145                 150                 155                 160 


Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly 
                165                 170                 175     


Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn 
            180                 185                 190         


Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly 
        195                 200                 205             


Ile Ile Ala Leu 
    210         


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HA tag seq 

<400> 28
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FLAG TAG 

<400> 29
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 30
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mIgG Heavy Chain IgG 1/3 hybrid anti-biotin heavy chain
      - E325A mutant sequence

<400> 30
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Tyr Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Leu Lys Thr Pro 
225                 230                 235                 240 


Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
        275                 280                 285             


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Ala Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu 
        515                 520                 525             


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu 
    530                 535                 540                 


Ser Val Cys Tyr Ser Ala Thr Val Thr Phe Phe Lys Val Lys Trp Ile 
545                 550                 555                 560 


Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Ile Pro Asp Tyr Arg 
                565                 570                 575     


Asn Met Ile Gly Gln Gly Ala 
            580             


<210> 31
<211> 223
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CD40L-TNFa fusion protein 

<400> 31
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Pro Val Ala 
65                  70                  75                  80  


His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn 
                85                  90                  95      


Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn 
            100                 105                 110         


Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val 
        115                 120                 125             


Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His 
    130                 135                 140                 


Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu 
145                 150                 155                 160 


Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu 
                165                 170                 175     


Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu 
            180                 185                 190         


Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu 
        195                 200                 205             


Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215                 220             


<210> 32
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Signal 

<400> 32
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210> 33
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Variable anti-biotin sequence

<400> 33
Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser Gly Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Val 
                85                  90                  95      


Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 34
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Constant Region 1 from IgG1 sequence

<400> 34
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu 
            


<210> 35
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Hinge Region from IgG3 sequence

<400> 35
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210> 36
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Constant Region 2 from IgG1 sequence

<400> 36
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210> 37
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HC Transmembrane and Cytoplasmic region from IgG1 sequence

<400> 37
Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr 
1               5                   10                  15      


Ile Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val 
            20                  25                  30          


Thr Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys 
        35                  40                  45              


Gln Thr Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
    50                  55                  60              


<210> 38
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      LC Signal sequence

<400> 38
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210> 39
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      LC Variable sequence

<400> 39
Gly Ser Pro Gly Gln Ser Val Ser Ile Ser Cys Ser Gly Ser Ser Ser 
1               5                   10                  15      


Asn Ile Gly Asn Asn Tyr Val Tyr Trp Tyr Gln His Leu Pro Gly Thr 
            20                  25                  30          


Ala Pro Lys Leu Leu Ile Tyr Ser Asp Thr Lys Arg Pro Ser Gly Val 
        35                  40                  45              


Pro Asp Arg Ile Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    50                  55                  60                  


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
65                  70                  75                  80  


Trp Asp Asp Ser Leu Asp Gly Pro Val Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu 
            


<210> 40
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      LC Constant Region 1 sequence

<400> 40
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210> 41
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mIgG Heavy Chain IgG 1/3 hybrid anti-biotin heavy chain
      sequence - T323A mutant

<400> 41
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Tyr Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Leu Lys Thr Pro 
225                 230                 235                 240 


Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
        275                 280                 285             


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Ala Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu 
        515                 520                 525             


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu 
    530                 535                 540                 


Ser Val Cys Tyr Ser Ala Thr Val Thr Phe Phe Lys Val Lys Trp Ile 
545                 550                 555                 560 


Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Ile Pro Asp Tyr Arg 
                565                 570                 575     


Asn Met Ile Gly Gln Gly Ala 
            580             


<210> 42
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      GM-CSF - HLA-I fusion peptide 

<400> 42
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


Glu Leu Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly 
145                 150                 155                 160 


Leu Val Leu Leu Gly Ala Val Ile Thr Gly Ala Val Val Ala Ala Val 
                165                 170                 175     


Met Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln 
            180                 185                 190         


Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        195                 200                 205             


Cys Lys Val 
    210     


<210> 43
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mIgG Heavy Chain IgG 1/3 hybrid anti-biotin heavy chain
      - E325A, T323A mutant 

<400> 43
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Tyr Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Leu Lys Thr Pro 
225                 230                 235                 240 


Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
        275                 280                 285             


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Ala Pro Ala Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu 
        515                 520                 525             


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu 
    530                 535                 540                 


Ser Val Cys Tyr Ser Ala Thr Val Thr Phe Phe Lys Val Lys Trp Ile 
545                 550                 555                 560 


Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Ile Pro Asp Tyr Arg 
                565                 570                 575     


Asn Met Ile Gly Gln Gly Ala 
            580             


<210> 44
<211> 183
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Soluble Flt3-L sequence

<400> 44
Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln 
            180             


<210> 45
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mIgG Heavy Chain IgG 1/3 hybrid anti-biotin heavy chain 
      sequence

<400> 45
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Tyr Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Leu Lys Thr Pro 
225                 230                 235                 240 


Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
        275                 280                 285             


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu 
        515                 520                 525             


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu 
    530                 535                 540                 


Ser Val Cys Tyr Ser Ala Thr Val Thr Phe Phe Lys Val Lys Trp Ile 
545                 550                 555                 560 


Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Ile Pro Asp Tyr Arg 
                565                 570                 575     


Asn Met Ile Gly Gln Gly Ala 
            580             


<210> 46
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG Light Chain sequence

<400> 46
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gly Ser Pro Gly Gln Ser Val Ser Ile Ser 
            20                  25                  30          


Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr Trp Tyr 
        35                  40                  45              


Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asp Thr 
    50                  55                  60                  


Lys Arg Pro Ser Gly Val Pro Asp Arg Ile Ser Gly Ser Lys Ser Gly 
65                  70                  75                  80  


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
                85                  90                  95      


Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu Asp Gly Pro Val Phe 
            100                 105                 110         


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro 
        115                 120                 125             


Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
    130                 135                 140                 


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
145                 150                 155                 160 


Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr 
                165                 170                 175     


Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
            180                 185                 190         


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
        195                 200                 205             


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
    210                 215                 220                 


Glu Cys Ser 
225         


<210> 47
<211> 9203
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 1 sequence

<400> 47
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg gagttcggcc     3180

tgagctgggt gttcctggtg gccctgttca gaggcgtgca gtgccaggtg aagctgcagg     3240

agagcggccc cggcctggtg gcccccagcc agagcctgag catcacctgc accgtgagcg     3300

gcttcagcct gaccgcctac ggcgtggact gggtgagaca gccccccggc aagtgcctgg     3360

agtggctggg cgtgatctgg ggcggcggca gaaccaacta caacagcggc ctgatgagca     3420

gactgagcat cagaaaggac aacagcaaga gccaggtgtt cctgaccatg aacagcctgc     3480

agaccgacga caccgccaag tactactgcg tgaagcacac caactgggac ggcggcttcg     3540

cctactgggg ccagggcacc accgtgaccg tgagcagcgg cggcggcggc agcggcggcg     3600

gcggcagcgg cggcggcggc agcggcagcc ccggccagag cgtgagcatc agctgcagcg     3660

gcagcagcag caacatcggc aacaactacg tgtactggta ccagcacctg cccggcaccg     3720

cccccaagct gctgatctac agcgacacca agagacccag cggcgtgccc gacagaatca     3780

gcggcagcaa gagcggcacc agcgccagcc tggccatcag cggcctgcag agcgaggacg     3840

aggccgacta ctactgcgcc agctgggacg acagcctgga cggccccgtg ttcggctgcg     3900

gcaccaagct gaccgtgctg ctgaagaccc ccctgggcga caccacccac acctgcccca     3960

gatgccccga gcccaagagc tgcgacaccc cccccccctg ccccagatgc cccgagccca     4020

agagctgcga cacccccccc ccctgcccca gatgccccga gcccaagagc tgcgacaccc     4080

cccccccctg ccccagatgc cccgcccccg agctgctggg cggccccagc gtgttcctgt     4140

tcccccccaa gcccaaggac accctgatga tcagcagagc ccccgaggtg acctgcgtgg     4200

tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg     4260

aggtgcacaa cgccaagacc aagcccagag aggagcagta caacagcacc tacagagtgg     4320

tgagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac aagtgcaagg     4380

tgagcaacaa ggccctgccc gcccccatcg agaagaccat cagcaaggcc aagggccagc     4440

ccagagagcc ccaggtgtac accctgcccc ccagcagaga cgagctgacc aagaaccagg     4500

tgagcctgac ctgcctggtg aagggcttct accccagcga catcgccgtg gagtgggaga     4560

gcaacggcca gcccgagaac aactacaaga ccaccccccc cgtgctggac agcgacggca     4620

gcttcttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag ggcaacgtgt     4680

tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag agcctgagcc     4740

tgagccccga gctgcagctg gaggagagct gcgccgaggc ccaggacggc gagctggacg     4800

gcctgtggac caccatcacc atcttcatca ccctgttcct gctgagcgtg tgctacagcg     4860

ccaccgtgac cttcttcaag gtgaagtgga tcttcagcag cgtggtggac ctgaagcaga     4920

ccatcatccc cgactacaga aacatgatcg gccagggcgc ctaaacccag ctttcttgta     4980

caaagtggtg ataatcgaat tctaaaccca gctttcttgt acaaagtggt gataatcgaa     5040

ttccgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     5100

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     5160

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     5220

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     5280

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     5340

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     5400

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg     5460

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     5520

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     5580

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg     5640

ggaattcccg cggttcgctt taagaccaat gacttacaag gcagctgtag atcttagcca     5700

ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct     5760

gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg     5820

ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt     5880

gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt     5940

gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt tataacttgc     6000

aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa     6060

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     6120

tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta     6180

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga     6240

ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag     6300

tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt     6360

attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta     6420

cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg     6480

cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct     6540

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg     6600

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg     6660

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac     6720

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct     6780

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     6840

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt     6900

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     6960

ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac     7020

ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc     7080

ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt     7140

cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct     7200

ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga     7260

tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag     7320

cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca     7380

actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga     7440

aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag     7500

tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc     7560

ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa     7620

tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt     7680

gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg     7740

gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt     7800

tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg     7860

gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat     7920

ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact     7980

gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa     8040

aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt     8100

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt     8160

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg     8220

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca     8280

gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt     8340

agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga     8400

taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc     8460

gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact     8520

gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaagaga gaaaggcgga     8580

caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg     8640

aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt     8700

tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt     8760

acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga     8820

ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac     8880

gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc     8940

tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa     9000

agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc     9060

tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca     9120

cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga     9180

acaaaagctg gagctgcaag ctt                                             9203


<210> 48
<211> 10862
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 2 sequence

<400> 48
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtatca actttgtata gaaaagttgg gctccggtgc ccgtcagtgg gcagagcgca     1980

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga     2040

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg     2100

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg     2160

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta     2220

cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac gtgattcttg     2280

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc     2340

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct     2400

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt     2460

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc     2520

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc     2580

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt     2640

ctcaagctgg ccggcctgct ctggtgcctg gtctcgcgcc gccgtgtatc gccccgccct     2700

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg     2760

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt     2820

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     2880

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     2940

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     3000

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     3060

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     3120

tgtcgtgaca agtttgtaca aaaaagcagg ctgccaccat ggagttcggc ctgagctggg     3180

tgttcctggt ggccctgttc agaggcgtgc agtgccaggt gaagctgcag gagagcggcc     3240

ccggcctggt ggcccccagc cagagcctga gcatcacctg caccgtgagc ggcttcagcc     3300

tgaccgccta cggcgtggac tgggtgagac agccccccgg caagggcctg gagtggctgg     3360

gcgtgatctg gggcggcggc agaaccaact acaacagcgg cctgatgagc agactgagca     3420

tcagaaagga caacagcaag agccaggtgt tcctgaccat gaacagcctg cagaccgacg     3480

acaccgccaa gtactactgc gtgaagcaca ccaactggga cggcggcttc gcctactggg     3540

gccagggcac caccgtgacc gtgagcagcc ccagcgtgtt ccccctggcc cccagcagca     3600

agagcaccag cggcggcacc gccgccctgg gctgcctggt gaaggactac ttccccgagc     3660

ccgtgaccgt gagctggaac agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg     3720

tgctgcagag cagcggcctg tacagcctga gcagcgtggt gaccgtgccc agcagcagcc     3780

tgggcaccca gacctacatc tgcaacgtga accacaagcc cagcaacacc aaggtggaca     3840

agaaggtgga gctgaagacc cccctgggcg acaccaccca cacctgcccc agatgccccg     3900

agcccaagag ctgcgacacc ccccccccct gccccagatg ccccgagccc aagagctgcg     3960

acaccccccc cccctgcccc agatgccccg agcccaagag ctgcgacacc ccccccccct     4020

gccccagatg ccccgccccc gagctgctgg gcggccccag cgtgttcctg ttccccccca     4080

agcccaagga caccctgatg atcagcagag cccccgaggt gacctgcgtg gtggtggacg     4140

tgagccacga ggaccccgag gtgaagttca actggtacgt ggacggcgtg gaggtgcaca     4200

acgccaagac caagcccaga gaggagcagt acaacagcac ctacagagtg gtgagcgtgc     4260

tgaccgtgct gcaccaggac tggctgaacg gcaaggagta caagtgcaag gtgagcaaca     4320

aggccctgcc cgcccccatc gagaagacca tcagcaaggc caagggccag cccagagagc     4380

cccaggtgta caccctgccc cccagcagag acgagctgac caagaaccag gtgagcctga     4440

cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag agcaacggcc     4500

agcccgagaa caactacaag accacccccc ccgtgctgga cagcgacggc agcttcttcc     4560

tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg ttcagctgca     4620

gcgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc ctgagccccg     4680

agctgcagct ggaggagagc tgcgccgagg cccaggacgg cgagctggac ggcctgtgga     4740

ccaccatcac catcttcatc accctgttcc tgctgagcgt gtgctacagc gccaccgtga     4800

ccttcttcaa ggtgaagtgg atcttcagca gcgtggtgga cctgaagcag accatcatcc     4860

ccgactacag aaacatgatc ggccagggcg cctaaaacaa caacaattgc attcatttta     4920

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     4980

gtggtacgcg ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg     5040

tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtacgcgtta cccagctttc     5100

ttgtacaaag tggtaaatag atagaacaac aacaattgca ttcatttttg atttcaggtt     5160

cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacactga cggtacgcgt     5220

taacaacaac aattgcattc atttgtagtt tcaggttcag ggggaggtgt gggaggtttt     5280

ttaaagcaag ttaaacctct aaaatagtgg tacgcgttac ccagctttct tgtacaaagt     5340

ggacccagct ttcttgtaca aagtgggccc ctctccctcc ccccccccta acgttactgg     5400

ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt     5460

gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc     5520

taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc     5580

agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg     5640

gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc     5700

tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa     5760

atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg     5820

tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa     5880

aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata     5940

atatggccac aaccatggcc accgacatga gagtgcccgc ccagctgctg ggcctgctgc     6000

tgctgtggct gagcggcgcc agatgcggca gccccggcca gagcgtgagc atcagctgca     6060

gcggcagcag cagcaacatc ggcaacaact acgtgtactg gtaccagcac ctgcccggca     6120

ccgcccccaa gctgctgatc tacagcgaca ccaagagacc cagcggcgtg cccgacagaa     6180

tcagcggcag caagagcggc accagcgcca gcctggccat cagcggcctg cagagcgagg     6240

acgaggccga ctactactgc gccagctggg acgacagcct ggacggcccc gtgttcggcg     6300

gcggcaccaa gctgaccgtg ctgggccagc ccaaggccaa ccccaccgtg accctgttcc     6360

cccccagcag cgaggagctg caggccaaca aggccaccct ggtgtgcctg atcagcgact     6420

tctaccccgg cgccgtgacc gtggcctgga aggccgacgg cagccccgtg aaggccggcg     6480

tggagaccac caagcccagc aagcagagca acaacaagta cgccgccagc agctacctga     6540

gcctgacccc cgagcagtgg aagagccaca gaagctacag ctgccaggtg acccacgagg     6600

gcagcaccgt ggagaagacc gtggccccca ccgagtgcag ctaacaactt tattatacat     6660

agttgatcaa ttccaacttt attatacata gttgatcaat tccgataatc aacctctgga     6720

ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg     6780

tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt     6840

ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag     6900

gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc     6960

caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga     7020

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     7080

ttccgtggtg ttgtcgggga agctgacgtc ctttccatgg ctgctcgcct gtgttgccac     7140

ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct     7200

tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca     7260

gacgagtcgg atctcccttt gggccgcctc cccgcatcgg gaattcccgc ggttcgcttt     7320

aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg     7380

actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt gtactgggtc     7440

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct     7500

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga     7560

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtag     7620

tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag     7680

tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa     7740

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa     7800

tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccat cccgccccta     7860

actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca     7920

gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga     7980

ggcctaggga cgtacccaat tcgccctata gtgagtcgta ttacgcgcgc tcactggccg     8040

tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag     8100

cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc     8160

aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg     8220

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     8280

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     8340

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     8400

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     8460

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     8520

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     8580

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta     8640

caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta     8700

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     8760

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     8820

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga     8880

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct     8940

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg     9000

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta     9060

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat     9120

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt     9180

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga     9240

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga     9300

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga     9360

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc     9420

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc     9480

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg     9540

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat     9600

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata     9660

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     9720

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     9780

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     9840

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     9900

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct     9960

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc    10020

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt    10080

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg    10140

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct    10200

atgagaaagc gccacgcttc ccgaagagag aaaggcggac aggtatccgg taagcggcag    10260

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag    10320

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg    10380

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg    10440

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac    10500

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt    10560

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat    10620

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc    10680

aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc    10740

tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca    10800

tgattacgcc aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgcaagc    10860

tt                                                                   10862


<210> 49
<211> 9581
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 3 sequence

<400> 49
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtatca actttgtata gaaaagttgg gctccggtgc ccgtcagtgg gcagagcgca     1980

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga     2040

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg     2100

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg     2160

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta     2220

cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac gtgattcttg     2280

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc     2340

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct     2400

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt     2460

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc     2520

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc     2580

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt     2640

ctcaagctgg ccggcctgct ctggtgcctg gtctcgcgcc gccgtgtatc gccccgccct     2700

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg     2760

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt     2820

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     2880

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     2940

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     3000

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     3060

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     3120

tgtcgtgaca agtttgtaca aaaaagcagg ctgccaccat gtggctgcag agcctgctgc     3180

tgctgggcac cgtggcctgc agcatcagcg cccccgccag aagccccagc cccagcaccc     3240

agccctggga gcacgtgaac gccatccagg aggccagaag actgctgaac ctgagcagag     3300

acaccgccgc cgagatgaac gagaccgtgg aggtgatcag cgagatgttc gacctgcagg     3360

agcccacctg cctgcagacc agactggagc tgtacaagca gggcctgaga ggcagcctga     3420

ccaagctgaa gggccccctg accatgatgg ccagccacta caagcagcac tgccccccca     3480

cccccgagac cagctgcgcc acccagatca tcaccttcga gagcttcaag gagaacctga     3540

aggacttcct gctggtgatc cccttcgact gctgggagcc cgtgcaggag taaaacaaca     3600

acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca     3660

agtaaaacct ctacaaatgt ggtacgcgtt aacaacaaca attgcattca ttttatgttt     3720

caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt     3780

acgcgttacc cagctttctt gtacaaagtg gtaaatagat agaacaacaa caattgcatt     3840

catttttgat ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc     3900

tacactgacg gtacgcgtta acaacaacaa ttgcattcat ttgtagtttc aggttcaggg     3960

ggaggtgtgg gaggtttttt aaagcaagtt aaacctctaa aatagtggta cgcgttaccc     4020

agctttcttg tacaaagtgg acccagcttt cttgtacaaa gtgggcccct ctccctcccc     4080

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat     4140

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt     4200

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt     4260

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc     4320

gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc     4380

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat     4440

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc     4500

ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg     4560

tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct     4620

ttgaaaaaca cgatgataat atggccacaa ccatggccac cgtgctggcc cccgcctgga     4680

gccccaccac ctacctgctg ctgctgctgc tgctgagcag cggcctgagc ggcacccagg     4740

actgcagctt ccagcacagc cccatcagca gcgacttcgc cgtgaagatc agagagctga     4800

gcgactacct gctgcaggac taccccgtga ccgtggccag caacctgcag gacgaggagc     4860

tgtgcggcgg cctgtggaga ctggtgctgg cccagagatg gatggagaga ctgaagaccg     4920

tggccggcag caagatgcag ggcctgctgg agagagtgaa caccgagatc cacttcgtga     4980

ccaagtgcgc cttccagccc ccccccagct gcctgagatt cgtgcagacc aacatcagca     5040

gactgctgca ggagaccagc gagcagctgg tggccctgaa gccctggatc accagacaga     5100

acttcagcag atgcctggag ctgcagtgcc agcccgacag cagcaccctg ccccccccct     5160

ggagccccag acccctggag gccaccgccc ccaccgcccc ccagcccccc ctgctgctgc     5220

tgctgctgct gcccgtgggc ctgctgctgc tggccgccgc ctggtgcctg cactggcaga     5280

gaaccagaag aagaaccccc agacccggcg agcaggtgcc ccccgtgccc agcccccagg     5340

acctgctgct ggtggagcac taacaacttt attatacata gttgatcaat tccaacttta     5400

ttatacatag ttgatcaatt ccgataatca acctctggat tacaaaattt gtgaaagatt     5460

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     5520

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     5580

gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac     5640

tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc     5700

cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc     5760

ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa     5820

gctgacgtcc tttccatggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc     5880

cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc     5940

ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg     6000

ggccgcctcc ccgcatcggg aattcccgcg gttcgcttta agaccaatga cttacaaggc     6060

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc     6120

ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg     6180

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc     6240

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct     6300

cagacccttt tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc atcttattat     6360

tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc     6420

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     6480

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct     6540

ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     6600

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc     6660

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt     6720

cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact     6780

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     6840

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg     6900

gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca     6960

gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct     7020

ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt     7080

tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac     7140

gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct     7200

ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt     7260

ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac     7320

aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg     7380

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc     7440

gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag     7500

tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt     7560

tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt     7620

gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga     7680

acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat     7740

tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga     7800

gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag     7860

tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg     7920

accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg     7980

ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt     8040

agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg     8100

gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc     8160

ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg     8220

tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac     8280

ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact     8340

gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa     8400

acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa     8460

aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg     8520

atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc     8580

gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac     8640

tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca     8700

ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt     8760

ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc     8820

ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg     8880

aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc     8940

cgaagagaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac     9000

gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct     9060

ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc     9120

cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt     9180

tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac     9240

cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg     9300

cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga     9360

caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac     9420

tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt     9480

gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat     9540

taaccctcac taaagggaac aaaagctgga gctgcaagct t                         9581


<210> 50
<211> 9746
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 4 sequence

<400> 50
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtatca actttgtata gaaaagttgg gctccggtgc ccgtcagtgg gcagagcgca     1980

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga     2040

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg     2100

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg     2160

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta     2220

cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac gtgattcttg     2280

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc     2340

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct     2400

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt     2460

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc     2520

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc     2580

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt     2640

ctcaagctgg ccggcctgct ctggtgcctg gtctcgcgcc gccgtgtatc gccccgccct     2700

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg     2760

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt     2820

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     2880

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     2940

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     3000

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     3060

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     3120

tgtcgtgaca agtttgtaca aaaaagcagg ctgccaccat gaccgtgctg gcccccgcct     3180

ggagccccac cacctacctg ctgctgctgc tgctgctgag cagcggcctg agcggcaccc     3240

aggactgcag cttccagcac agccccatca gcagcgactt cgccgtgaag atcagagagc     3300

tgagcgacta cctgctgcag gactaccccg tgaccgtggc cagcaacctg caggacgagg     3360

agctgtgcgg cggcctgtgg agactggtgc tggcccagag atggatggag agactgaaga     3420

ccgtggccgg cagcaagatg cagggcctgc tggagagagt gaacaccgag atccacttcg     3480

tgaccaagtg cgccttccag ccccccccca gctgcctgag attcgtgcag accaacatca     3540

gcagactgct gcaggagacc agcgagcagc tggtggccct gaagccctgg atcaccagac     3600

agaacttcag cagatgcctg gagctgcagt gccagcccga cagcagcacc ctgccccccc     3660

cctggagccc cagacccctg gaggccaccg cccccaccgc cccccagtaa aacaacaaca     3720

attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt     3780

aaaacctcta caaatgtggt acgcgttaac aacaacaatt gcattcattt tatgtttcag     3840

gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtacg     3900

cgttacccag ctttcttgta caaagtggta aatagataga acaacaacaa ttgcattcat     3960

ttttgatttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac     4020

actgacggta cgcgttaaca acaacaattg cattcatttg tagtttcagg ttcaggggga     4080

ggtgtgggag gttttttaaa gcaagttaaa cctctaaaat agtggtacgc gttacccagc     4140

tttcttgtac aaagtggacc cagctttctt gtacaaagtg ggcccctctc cctccccccc     4200

ccctaacgtt actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt     4260

attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt     4320

cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa     4380

tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac     4440

cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg     4500

tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt     4560

tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca     4620

gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct ttacatgtgt     4680

ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg     4740

aaaaacacga tgataatatg gccacaacca tggccaccgt gctggccccc gcctggagcc     4800

ccaccaccta cctgctgctg ctgctgctgc tgagcagcgg cctgagcgcc cccgccagaa     4860

gccccagccc cagcacccag ccctgggagc acgtgaacgc catccaggag gccagaagac     4920

tgctgaacct gagcagagac accgccgccg agatgaacga gaccgtggag gtgatcagcg     4980

agatgttcga cctgcaggag cccacctgcc tgcagaccag actggagctg tacaagcagg     5040

gcctgagagg cagcctgacc aagctgaagg gccccctgac catgatggcc agccactaca     5100

agcagcactg cccccccacc cccgagacca gctgcgccac ccagatcatc accttcgaga     5160

gcttcaagga gaacctgaag gacttcctgc tggtgatccc cttcgactgc tgggagcccg     5220

tgcaggagcc caccaccacc cccgccccca gaccccccac ccccgccccc accatcgcca     5280

gccagcccct gagcctgaga cccgaggcct gcagacccgc cgccggcggc gccgtgcaca     5340

ccagaggcct ggacttcgcc tgcgacatct acatctgggc ccccctggcc ggcacctgcg     5400

gcgtgctgct gctgagcctg gtgatcaccc tgtactgcaa ccacagaaac agaagaagag     5460

tgtgcaagtg ccccagaccc gtggtgaaga gcggcgacaa gcccagcctg agcgccagat     5520

acgtgtaaca actttattat acatagttga tcaattccaa ctttattata catagttgat     5580

caattccgat aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     5640

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     5700

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     5760

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     5820

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     5880

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     5940

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc     6000

atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     6060

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     6120

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     6180

tcgggaattc ccgcggttcg ctttaagacc aatgacttac aaggcagctg tagatcttag     6240

ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga     6300

tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc     6360

tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt     6420

agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc     6480

agtgtggaaa atctctagca gtagtagttc atgtcatctt attattcagt atttataact     6540

tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta     6600

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag     6660

ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc     6720

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc     6780

tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag     6840

aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt     6900

cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     6960

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     7020

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc     7080

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     7140

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     7200

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     7260

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     7320

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     7380

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     7440

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     7500

attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg     7560

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     7620

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     7680

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     7740

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     7800

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     7860

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     7920

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     7980

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     8040

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     8100

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     8160

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     8220

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     8280

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     8340

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     8400

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     8460

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     8520

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     8580

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     8640

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     8700

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     8760

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     8820

gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc     8880

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     8940

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     9000

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     9060

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag agagaaaggc     9120

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     9180

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     9240

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     9300

tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc     9360

tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg     9420

aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc     9480

gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg     9540

gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca     9600

ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt     9660

tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag     9720

ggaacaaaag ctggagctgc aagctt                                          9746


<210> 51
<211> 8189
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 5 sequence

<400> 51
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg atcgagacct     3180

acaaccagac cagccccaga agcgccgcca ccggcctgcc catcagcatg aagatcttca     3240

tgtacctgct gaccgtgttc ctgatcaccc agatgatcgg cagcgccctg ttcgccgtgt     3300

acctgcacag aagactggac aagatcgagg acgagagaaa cctgcacgag gacttcgtgt     3360

tcatgaagac catccagaga tgcaacaccg gcgagagaag cctgagcctg ctgaactgcg     3420

aggagatcaa gagccagttc gagggcttcg tgaaggacat catgctgaac aaggaggaga     3480

ccaagaagga gaacagcttc gagatgccca gaggcgagga ggacagccag atcgccgccc     3540

acgtgatcag cgaggccagc agcaagacca ccagcgtgct gcagtgggcc gagaagggct     3600

actacaccat gagcaacaac ctggtgaccc tggagaacgg caagcagctg accgtgaaga     3660

gacagggcct gtactacatc tacgcccagg tgaccttctg cagcaacaga gaggccagca     3720

gccaggcccc cttcatcgcc agcctgtgcc tgaagagccc cggcagattc gagagaatcc     3780

tgctgagagc cgccaacacc cacagcagcg ccaagccctg cggccagcag agcatccacc     3840

tgggcggcgt gttcgagctg cagcccggcg ccagcgtgtt cgtgaacgtg accgacccca     3900

gccaggtgag ccacggcacc ggcttcacca gcttcggcct gctgaagctg taaacccagc     3960

tttcttgtac aaagtggtga taatcgaatt cacccagctt tcttgtacaa agtggtgata     4020

atcgaattcc gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct     4080

taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc     4140

tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct     4200

ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga     4260

cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc     4320

tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac     4380

aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt     4440

tccatggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt     4500

cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc     4560

tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc     4620

gcatcgggaa ttcccgcggt tcgctttaag accaatgact tacaaggcag ctgtagatct     4680

tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc aacgaagaca     4740

agatctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag cctgggagct     4800

ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca     4860

agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta     4920

gtcagtgtgg aaaatctcta gcagtagtag ttcatgtcat cttattattc agtatttata     4980

acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg     5040

ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc     5100

tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg     5160

cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat     5220

ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc     5280

cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg     5340

agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     5400

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     5460

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg     5520

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     5580

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     5640

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     5700

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     5760

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     5820

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     5880

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     5940

cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg     6000

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     6060

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     6120

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     6180

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     6240

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     6300

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     6360

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     6420

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     6480

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     6540

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     6600

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     6660

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     6720

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     6780

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     6840

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     6900

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     6960

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     7020

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     7080

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     7140

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     7200

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     7260

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa     7320

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     7380

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     7440

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     7500

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagagagaaa     7560

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     7620

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     7680

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     7740

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     7800

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     7860

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa     7920

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga     7980

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc     8040

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca     8100

atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta     8160

aagggaacaa aagctggagc tgcaagctt                                       8189


<210> 52
<211> 8069
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 6 sequence

<400> 52
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg agcaccgaga     3180

gcatgatcag agacgtggag ctggccgagg aggccctgcc caagaagacc ggcggccccc     3240

agggcagcag aagatgcctg ttcctgagcc tgttcagctt cctgatcgtg gccggcgcca     3300

ccaccctgtt ctgcctgctg cacttcggcg tgatcggccc ccagagagag gagttcccca     3360

gagacctgag cctgatcagc cccctggccc aggccgtggc ccacgtggtg gccaaccccc     3420

aggccgaggg ccagctgcag tggctgaaca gaagagccaa cgccctgctg gccaacggcg     3480

tggagctgag agacaaccag ctggtggtgc ccagcgaggg cctgtacctg atctacagcc     3540

aggtgctgtt caagggccag ggctgcccca gcacccacgt gctgctgacc cacaccatca     3600

gcagaatcgc cgtgagctac cagaccaagg tgaacctgct gagcgccatc aagagcccct     3660

gccagagaga gacccccgag ggcgccgagg ccaagccctg gtacgagccc atctacctgg     3720

gcggcgtgtt ccagctggag aagggcgaca gactgagcgc cgagatcaac agacccgact     3780

acctggactt cgccgagagc ggccaggtgt acttcggcat catcgccctg taaacccagc     3840

tttcttgtac aaagtggtga taatcgaatt cacccagctt tcttgtacaa agtggtgata     3900

atcgaattcc gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct     3960

taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc     4020

tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct     4080

ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga     4140

cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc     4200

tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac     4260

aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt     4320

tccatggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt     4380

cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc     4440

tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc     4500

gcatcgggaa ttcccgcggt tcgctttaag accaatgact tacaaggcag ctgtagatct     4560

tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc aacgaagaca     4620

agatctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag cctgggagct     4680

ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca     4740

agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta     4800

gtcagtgtgg aaaatctcta gcagtagtag ttcatgtcat cttattattc agtatttata     4860

acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg     4920

ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc     4980

tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg     5040

cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat     5100

ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc     5160

cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg     5220

agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     5280

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     5340

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg     5400

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     5460

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     5520

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     5580

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     5640

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     5700

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     5760

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     5820

cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg     5880

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     5940

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     6000

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     6060

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     6120

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     6180

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     6240

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     6300

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     6360

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     6420

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     6480

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     6540

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     6600

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     6660

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     6720

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     6780

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     6840

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     6900

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     6960

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     7020

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     7080

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     7140

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa     7200

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     7260

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     7320

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     7380

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagagagaaa     7440

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     7500

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     7560

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     7620

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     7680

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     7740

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa     7800

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga     7860

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc     7920

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca     7980

atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta     8040

aagggaacaa aagctggagc tgcaagctt                                       8069


<210> 53
<211> 10067
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Vector 7 sequence

<400> 53
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtatca actttgtata gaaaagttgg gctccggtgc ccgtcagtgg gcagagcgca     1980

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga     2040

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg     2100

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg     2160

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta     2220

cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac gtgattcttg     2280

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc     2340

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct     2400

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt     2460

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc     2520

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc     2580

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt     2640

ctcaagctgg ccggcctgct ctggtgcctg gtctcgcgcc gccgtgtatc gccccgccct     2700

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg     2760

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt     2820

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     2880

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     2940

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     3000

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     3060

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     3120

tgtcgtgaca agtttgtaca aaaaagcagg ctgccaccat gagcaccgag agcatgatca     3180

gagacgtgga gctggccgag gaggccctgc ccaagaagac cggcggcccc cagggcagca     3240

gaagatgcct gttcctgagc ctgttcagct tcctgatcgt ggccggcgcc accaccctgt     3300

tctgcctgct gcacttcggc gtgatcggcc cccagagaga ggagttcccc agagacctga     3360

gcctgatcag ccccctggcc caggccgtgg cccacgtggt ggccaacccc caggccgagg     3420

gccagctgca gtggctgaac agaagagcca acgccctgct ggccaacggc gtggagctga     3480

gagacaacca gctggtggtg cccagcgagg gcctgtacct gatctacagc caggtgctgt     3540

tcaagggcca gggctgcccc agcacccacg tgctgctgac ccacaccatc agcagaatcg     3600

ccgtgagcta ccagaccaag gtgaacctgc tgagcgccat caagagcccc tgccagagag     3660

agacccccga gggcgccgag gccaagccct ggtacgagcc catctacctg ggcggcgtgt     3720

tccagctgga gaagggcgac agactgagcg ccgagatcaa cagacccgac tacctggact     3780

tcgccgagag cggccaggtg tacttcggca tcatcgccct gtaaacccag ctttcttgta     3840

caaagtggtg ataatcgaat tctaaataga tagaacaaca acaattgcat tcatttttga     3900

tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacactgac     3960

ggtacgcgtt aacaacaaca attgcattca tttgtagttt caggttcagg gggaggtgtg     4020

ggaggttttt taaagcaagt taaacctcta aaatagtggt acgcgttacc cagctttctt     4080

gtacaaagtg gacccagctt tcttgtacaa agtgggcccc tctccctccc ccccccctaa     4140

cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc     4200

caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac     4260

gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt     4320

gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg     4380

caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata     4440

agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga     4500

aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt     4560

accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc     4620

gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac     4680

acgatgataa tatggccaca accatggcca ccgtgctggc ccccgcctgg agccccacca     4740

cctacctgct gctgctgctg ctgctgagca gcggcctgag cggcggcggc ggcagcggca     4800

agcccatccc caaccccctg ctgggcctgg acagcaccgg cggcggcggc agccaggtga     4860

agctgcagga gagcggcccc ggcctggtgg cccccagcca gagcctgagc atcacctgca     4920

ccgtgagcgg cttcagcctg accgcctacg gcgtggactg ggtgagacag ccccccggca     4980

agtgcctgga gtggctgggc gtgatctggg gcggcggcag aaccaactac aacagcggcc     5040

tgatgagcag actgagcatc agaaaggaca acagcaagag ccaggtgttc ctgaccatga     5100

acagcctgca gaccgacgac accgccaagt actactgcgt gaagcacacc aactgggacg     5160

gcggcttcgc ctactggggc cagggcacca ccgtgaccgt gagcagcggc ggcggcggca     5220

gcggcggcgg cggcagcggc ggcggcggca gcggcagccc cggccagagc gtgagcatca     5280

gctgcagcgg cagcagcagc aacatcggca acaactacgt gtactggtac cagcacctgc     5340

ccggcaccgc ccccaagctg ctgatctaca gcgacaccaa gagacccagc ggcgtgcccg     5400

acagaatcag cggcagcaag agcggcacca gcgccagcct ggccatcagc ggcctgcaga     5460

gcgaggacga ggccgactac tactgcgcca gctgggacga cagcctggac ggccccgtgt     5520

tcggctgcgg caccaagctg accgtgctgc ccaccaccac ccccgccccc agacccccca     5580

cccccgcccc caccatcgcc agccagcccc tgagcctgag acccgaggcc tgcagacccg     5640

ccgccggcgg cgccgtgcac accagaggcc tggacttcgc ctgcgacatc tacatctggg     5700

cccccctggc cggcacctgc ggcgtgctgc tgctgagcct ggtgatcacc ctgtactgca     5760

accacagaaa cagaagaaga gtgtgcaagt gccccagacc cgtggtgaag agcggcgaca     5820

agcccagcct gagcgccaga tacgtgtaac aactttatta tacatagttg atcaattcca     5880

actttattat acatagttga tcaattccga taatcaacct ctggattaca aaatttgtga     5940

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     6000

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     6060

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     6120

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     6180

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     6240

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     6300

ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga ttctgcgcgg     6360

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     6420

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     6480

cctttgggcc gcctccccgc atcgggaatt cccgcggttc gctttaagac caatgactta     6540

caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat     6600

tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct ggttagacca     6660

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     6720

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     6780

atccctcaga cccttttagt cagtgtggaa aatctctagc agtagtagtt catgtcatct     6840

tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt     6900

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     6960

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     7020

ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc     7080

gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc     7140

tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac     7200

ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc     7260

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     7320

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     7380

tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     7440

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     7500

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     7560

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     7620

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     7680

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     7740

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     7800

tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac     7860

ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat     7920

gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag     7980

tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc     8040

tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc     8100

acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc     8160

cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc     8220

ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt     8280

ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt     8340

atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat     8400

cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct     8460

tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat     8520

gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc     8580

ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg     8640

ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc     8700

tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta     8760

cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc     8820

ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga     8880

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     8940

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     9000

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     9060

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     9120

ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt     9180

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     9240

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     9300

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     9360

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     9420

gcttcccgaa gagagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     9480

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     9540

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     9600

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat     9660

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc     9720

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga     9780

agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg     9840

gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta     9900

gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg     9960

aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg    10020

cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagctt                  10067


<210> 54
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      L1 light chain leader sequence

<400> 54
Met Ala Thr Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Trp Leu Ser Gly Ala Arg Cys 
            20                  


<210> 55
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      anti-biotin murine sequence vH with inserted Cys for 
      inter-domain linkage 

<400> 55
Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser Gly Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Val 
                85                  90                  95      


Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 57
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light Chain Variable (human lambda variable) sequence

<400> 57
Gly Ser Pro Gly Gln Ser Val Ser Ile Ser Cys Ser Gly Ser Ser Ser 
1               5                   10                  15      


Asn Ile Gly Asn Asn Tyr Val Tyr Trp Tyr Gln His Leu Pro Gly Thr 
            20                  25                  30          


Ala Pro Lys Leu Leu Ile Tyr Ser Asp Thr Lys Arg Pro Ser Gly Val 
        35                  40                  45              


Pro Asp Arg Ile Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    50                  55                  60                  


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
65                  70                  75                  80  


Trp Asp Asp Ser Leu Asp Gly Pro Val Phe Gly Cys Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu 
            


<210> 58
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG3 hinge for greater accessibility to FcyR sequence

<400> 58
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210> 59
<211> 283
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 CH2, CH3 Tm and cytoplasmic tail (T256A) sequence

<400> 59
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
1               5                   10                  15      


Thr Leu Met Ile Ser Arg Ala Pro Glu Val Thr Cys Val Val Val Asp 
            20                  25                  30          


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        35                  40                  45              


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    50                  55                  60                  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
65                  70                  75                  80  


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                85                  90                  95      


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln 
    210                 215                 220                 


Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr 
225                 230                 235                 240 


Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val Thr Phe Phe Lys 
                245                 250                 255     


Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Ile 
            260                 265                 270         


Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
        275                 280             


<210> 60
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      scFv-anti-biotin-G3hinge-IgG1-Tm (598 ORF1) sequence

<400> 60
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Cys Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Tyr Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Pro Gly Gln Ser Val Ser 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr 
                165                 170                 175     


Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asp Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Ile Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu Asp Gly Pro 
225                 230                 235                 240 


Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Leu Lys Thr Pro Leu 
                245                 250                 255     


Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
        275                 280                 285             


Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
    290                 295                 300                 


Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                325                 330                 335     


Arg Ala Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            340                 345                 350         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        355                 360                 365             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    370                 375                 380                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                405                 410                 415     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            420                 425                 430         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        435                 440                 445             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    450                 455                 460                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
465                 470                 475                 480 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                485                 490                 495     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            500                 505                 510         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Glu 
        515                 520                 525             


Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu Asp 
    530                 535                 540                 


Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu Ser 
545                 550                 555                 560 


Val Cys Tyr Ser Ala Thr Val Thr Phe Phe Lys Val Lys Trp Ile Phe 
                565                 570                 575     


Ser Ser Val Val Asp Leu Lys Gln Thr Ile Ile Pro Asp Tyr Arg Asn 
            580                 585                 590         


Met Ile Gly Gln Gly Ala 
        595             


<210> 61
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      H7 heavy chain leader sequence

<400> 61
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210> 62
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      anti-biotin vH sequence

<400> 62
Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser Gly Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Val 
                85                  90                  95      


Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 63
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CH1 sequence

<400> 63
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
1               5                   10                  15      


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            20                  25                  30          


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        35                  40                  45              


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    50                  55                  60                  


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
65                  70                  75                  80  


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                85                  90                  


<210> 64
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG3 hinge sequence

<400> 64
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210> 65
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 CH2, CH3 Tm and cytoplasmic tail sequence

<400> 65
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Ala Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala 
    210                 215                 220                 


Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile 
225                 230                 235                 240 


Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val Thr 
                245                 250                 255     


Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln 
            260                 265                 270         


Thr Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
        275                 280                 285     


<210> 66
<211> 578
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (578 ORF2a) sequence

<400> 66
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Tyr Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
225                 230                 235                 240 


His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
                245                 250                 255     


Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            260                 265                 270         


Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    290                 295                 300                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Ala Pro Glu 
305                 310                 315                 320 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                325                 330                 335     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            340                 345                 350         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        355                 360                 365             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    370                 375                 380                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
385                 390                 395                 400 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                405                 410                 415     


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            420                 425                 430         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        435                 440                 445             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    450                 455                 460                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
465                 470                 475                 480 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                485                 490                 495     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu 
            500                 505                 510         


Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr 
        515                 520                 525             


Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser 
    530                 535                 540                 


Ala Thr Val Thr Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val 
545                 550                 555                 560 


Asp Leu Lys Gln Thr Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln 
                565                 570                 575     


Gly Ala 
        


<210> 67
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Ile Arg Glu Ser 
1               


<210> 68
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      L1 Signal sequence

<400> 68
Met Ala Thr Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Trp Leu Ser Gly Ala Arg Cys 
            20                  


<210> 69
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      LC Variable sequence

<400> 69
Gly Ser Pro Gly Gln Ser Val Ser Ile Ser Cys Ser Gly Ser Ser Ser 
1               5                   10                  15      


Asn Ile Gly Asn Asn Tyr Val Tyr Trp Tyr Gln His Leu Pro Gly Thr 
            20                  25                  30          


Ala Pro Lys Leu Leu Ile Tyr Ser Asp Thr Lys Arg Pro Ser Gly Val 
        35                  40                  45              


Pro Asp Arg Ile Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    50                  55                  60                  


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
65                  70                  75                  80  


Trp Asp Asp Ser Leu Asp Gly Pro Val Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu 
            


<210> 70
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      LC Constant Region 1

<400> 70
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210> 71
<211> 229
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (229 ORF2b) sequence

<400> 71
Met Ala Thr Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Trp Leu Ser Gly Ala Arg Cys Gly Ser Pro Gly Gln Ser Val Ser 
            20                  25                  30          


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr 
        35                  40                  45              


Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
    50                  55                  60                  


Asp Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Ile Ser Gly Ser Lys 
65                  70                  75                  80  


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
                85                  90                  95      


Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu Asp Gly Pro 
            100                 105                 110         


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
        115                 120                 125             


Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
    130                 135                 140                 


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
145                 150                 155                 160 


Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val 
                165                 170                 175     


Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
            180                 185                 190         


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
        195                 200                 205             


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
    210                 215                 220                 


Pro Thr Glu Cys Ser 
225                 


<210> 72
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      GM-CSF signal sequence 

<400> 72
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser 
    


<210> 73
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      wild type GM-CSF sequence 

<400> 73
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 74
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Ile Arg Glu Ser 
1               


<210> 75
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FLT3L signal sequence

<400> 75
Met Ala Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ser Gly Leu Ser 
            20                  25      


<210> 76
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FLT3L sequence

<400> 76
Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 
1               5                   10                  15      


Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 
            20                  25                  30          


Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 
        35                  40                  45              


Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 
    50                  55                  60                  


Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 
65                  70                  75                  80  


His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 
                85                  90                  95      


Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 
            100                 105                 110         


Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 
        115                 120                 125             


Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp 
    130                 135                 140                 


Ser Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala 
                165                 170                 175     


Ala Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro 
            180                 185                 190         


Gly Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val 
        195                 200                 205             


Glu His 
    210 


<210> 77
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (144 ORF3a) sequence

<400> 77
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 78
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (236 ORF3b) sequence

<400> 78
Met Ala Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser 
            20                  25                  30          


Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 
        35                  40                  45              


Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 
    50                  55                  60                  


Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 
65                  70                  75                  80  


Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
                85                  90                  95      


Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 
            100                 105                 110         


Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 
        115                 120                 125             


Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 
    130                 135                 140                 


Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 
145                 150                 155                 160 


Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu 
                165                 170                 175     


Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp 
        195                 200                 205             


Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro 
    210                 215                 220                 


Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235     


<210> 79
<211> 183
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      wild type FLT3L sequence with transmembrane deleted 

<400> 79
Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln 
            180             


<210> 80
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Ile Arg Glu Ser 
1               


<210> 81
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FLT3L signal sequence

<400> 81
Met Ala Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ser Gly Leu Ser 
            20                  25      


<210> 82
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      wild type GM-CSF sequence 

<400> 82
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 83
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CD8alpha transmembrane and cytoplasmic domain 

<400> 83
Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45              


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    50                  55                  60                  


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys 
65                  70                  75                  80  


Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala 
                85                  90                  95      


Arg Tyr Val 
            


<210> 84
<211> 183
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary for CYAGEN (253 ORF4b) sequence

<400> 84
Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln 
            180             


<210> 85
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary for CYAGEN (253 ORF4b) sequence

<400> 85
Met Ala Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ser Gly Leu Ser Ala Pro Ala Arg Ser Pro 
            20                  25                  30          


Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala 
        35                  40                  45              


Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu 
    50                  55                  60                  


Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys 
65                  70                  75                  80  


Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu 
                85                  90                  95      


Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln 
            100                 105                 110         


His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr 
        115                 120                 125             


Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro 
    130                 135                 140                 


Phe Asp Cys Trp Glu Pro Val Gln Glu Pro Thr Thr Thr Pro Ala Pro 
145                 150                 155                 160 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                165                 170                 175     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            180                 185                 190         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        195                 200                 205             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
    210                 215                 220                 


His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys 
225                 230                 235                 240 


Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
                245                 250         


<210> 86
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mCD40L sequence modified to stop cleavage 

<400> 86
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Pro Arg Gly Glu Glu Asp Ser Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 87
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (261 ORF5) sequence

<400> 87
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Pro Arg Gly Glu Glu Asp Ser Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 88
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mTNFalpha sequence modified to stop cleavage 

<400> 88
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Ala His Val 
65                  70                  75                  80  


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
                85                  90                  95      


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
            100                 105                 110         


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
        115                 120                 125             


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
    130                 135                 140                 


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
145                 150                 155                 160 


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
                165                 170                 175     


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
            180                 185                 190         


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
        195                 200                 205             


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215                 220     


<210> 89
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (221 ORF6) sequence

<400> 89
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Ala His Val 
65                  70                  75                  80  


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
                85                  90                  95      


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
            100                 105                 110         


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
        115                 120                 125             


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
    130                 135                 140                 


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
145                 150                 155                 160 


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
                165                 170                 175     


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
            180                 185                 190         


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
        195                 200                 205             


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215                 220     


<210> 90
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      wild-type

<400> 90
Met Asp Pro Asn Arg Ile Ser Glu Asp Gly Thr His Cys Ile Tyr Arg 
1               5                   10                  15      


Ile Leu Arg Leu His Glu Asn Ala Asp Phe Gln Asp Thr Thr Leu Glu 
            20                  25                  30          


Ser Gln Asp Thr Lys Leu Ile Pro Asp Ser Cys Arg Arg Ile Lys Gln 
        35                  40                  45              


Ala Phe Gln Gly Ala Val Gln Lys Glu Leu Gln His Ile Val Gly Ser 
    50                  55                  60                  


Gln His Ile Arg Ala Glu Lys Ala Met Val Asp Gly Ser Trp Leu Asp 
65                  70                  75                  80  


Leu Ala Lys Arg Ser Lys Leu Glu Ala Gln Pro Phe Ala His Leu Thr 
                85                  90                  95      


Ile Asn Ala Thr Asp Ile Pro Ser Gly Ser His Lys Val Ser Leu Ser 
            100                 105                 110         


Ser Trp Tyr His Asp Arg Gly Trp Ala Lys Ile Ser Asn Met Thr Phe 
        115                 120                 125             


Ser Asn Gly Lys Leu Ile Val Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr 
    130                 135                 140                 


Ala Asn Ile Cys Phe Arg His His Glu Thr Ser Gly Asp Leu Ala Thr 
145                 150                 155                 160 


Glu Tyr Leu Gln Leu Met Val Tyr Val Thr Lys Thr Ser Ile Lys Ile 
                165                 170                 175     


Pro Ser Ser His Thr Leu Met Lys Gly Gly Ser Thr Lys Tyr Trp Ser 
            180                 185                 190         


Gly Asn Ser Glu Phe His Phe Tyr Ser Ile Asn Val Gly Gly Phe Phe 
        195                 200                 205             


Lys Leu Arg Ser Gly Glu Glu Ile Ser Ile Glu Val Ser Asn Pro Ser 
    210                 215                 220                 


Leu Leu Asp Pro Asp Gln Asp Ala Thr Tyr Phe Gly Ala Phe Lys Val 
225                 230                 235                 240 


Arg Asp Ile Asp 
                


<210> 91
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Ile Arg Glu Ser 
1               


<210> 92
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FLT3L signal 

<400> 92
Met Ala Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ser Gly Leu Ser 
            20                  25      


<210> 93
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Linker

<400> 93
Gly Gly Gly Gly Ser 
1               5   


<210> 94
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V5 epitope tag for flow detection 

<400> 94
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 95
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      anti-biotin murine vH with inserted Cys for 
      intralinkage 

<400> 95
Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser Gly Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Val 
                85                  90                  95      


Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 96
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Linker

<400> 96
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 97
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      LC Variable sequence

<400> 97
Gly Ser Pro Gly Gln Ser Val Ser Ile Ser Cys Ser Gly Ser Ser Ser 
1               5                   10                  15      


Asn Ile Gly Asn Asn Tyr Val Tyr Trp Tyr Gln His Leu Pro Gly Thr 
            20                  25                  30          


Ala Pro Lys Leu Leu Ile Tyr Ser Asp Thr Lys Arg Pro Ser Gly Val 
        35                  40                  45              


Pro Asp Arg Ile Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    50                  55                  60                  


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
65                  70                  75                  80  


Trp Asp Asp Ser Leu Asp Gly Pro Val Phe Gly Cys Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu 
            


<210> 98
<211> 99
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CD8alpha transmembrane and cytoplasmic domain 

<400> 98
Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45              


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    50                  55                  60                  


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys 
65                  70                  75                  80  


Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala 
                85                  90                  95      


Arg Tyr Val 
            


<210> 99
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (244 ORF7a) sequence

<400> 99
Met Asp Pro Asn Arg Ile Ser Glu Asp Gly Thr His Cys Ile Tyr Arg 
1               5                   10                  15      


Ile Leu Arg Leu His Glu Asn Ala Asp Phe Gln Asp Thr Thr Leu Glu 
            20                  25                  30          


Ser Gln Asp Thr Lys Leu Ile Pro Asp Ser Cys Arg Arg Ile Lys Gln 
        35                  40                  45              


Ala Phe Gln Gly Ala Val Gln Lys Glu Leu Gln His Ile Val Gly Ser 
    50                  55                  60                  


Gln His Ile Arg Ala Glu Lys Ala Met Val Asp Gly Ser Trp Leu Asp 
65                  70                  75                  80  


Leu Ala Lys Arg Ser Lys Leu Glu Ala Gln Pro Phe Ala His Leu Thr 
                85                  90                  95      


Ile Asn Ala Thr Asp Ile Pro Ser Gly Ser His Lys Val Ser Leu Ser 
            100                 105                 110         


Ser Trp Tyr His Asp Arg Gly Trp Ala Lys Ile Ser Asn Met Thr Phe 
        115                 120                 125             


Ser Asn Gly Lys Leu Ile Val Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr 
    130                 135                 140                 


Ala Asn Ile Cys Phe Arg His His Glu Thr Ser Gly Asp Leu Ala Thr 
145                 150                 155                 160 


Glu Tyr Leu Gln Leu Met Val Tyr Val Thr Lys Thr Ser Ile Lys Ile 
                165                 170                 175     


Pro Ser Ser His Thr Leu Met Lys Gly Gly Ser Thr Lys Tyr Trp Ser 
            180                 185                 190         


Gly Asn Ser Glu Phe His Phe Tyr Ser Ile Asn Val Gly Gly Phe Phe 
        195                 200                 205             


Lys Leu Arg Ser Gly Glu Glu Ile Ser Ile Glu Val Ser Asn Pro Ser 
    210                 215                 220                 


Leu Leu Asp Pro Asp Gln Asp Ala Thr Tyr Phe Gly Ala Phe Lys Val 
225                 230                 235                 240 


Arg Asp Ile Asp 
                


<210> 100
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Summary (381aa ORF7b) sequence

<400> 100
Met Ala Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Gly Gly 
        35                  40                  45              


Gly Ser Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    50                  55                  60                  


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
65                  70                  75                  80  


Ala Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Cys Leu Glu 
                85                  90                  95      


Trp Leu Gly Val Ile Trp Gly Gly Gly Arg Thr Asn Tyr Asn Ser Gly 
            100                 105                 110         


Leu Met Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val 
        115                 120                 125             


Phe Leu Thr Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr 
    130                 135                 140                 


Cys Val Lys His Thr Asn Trp Asp Gly Gly Phe Ala Tyr Trp Gly Gln 
145                 150                 155                 160 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ser Pro Gly Gln Ser Val Ser Ile 
            180                 185                 190         


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr Trp 
        195                 200                 205             


Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asp 
    210                 215                 220                 


Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Ile Ser Gly Ser Lys Ser 
225                 230                 235                 240 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu 
                245                 250                 255     


Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu Asp Gly Pro Val 
            260                 265                 270         


Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Pro Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            340                 345                 350         


Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
        355                 360                 365             


Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
    370                 375                 380     


<210> 101
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 101
Gln Met Gln Gly Val Asn Cys Thr Val Ser Ser 
1               5                   10      


<210> 102
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CpG sequence 

<400> 102
ggaaccgtat cggcgatatc ggttgggggg                                        30


<210> 103
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CpG sequence

<400> 103
ggaaccgtat gcggcatatc ggttgggggg                                        30


<210> 104
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 104
Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro 
1               5                   10          


<210> 105
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 105
Met Tyr Pro Pro Pro Tyr 
1               5       


<210> 106
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 106
Tyr Met Asn Met 
1               


<210> 107
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 107
Pro Tyr Ala Pro 
1               


<210> 108
<211> 183
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210> 109
<211> 193
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210> 110
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210> 111
<211> 329
<212> PRT
<213> Homo sapiens

<400> 111
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210> 112
<211> 7917
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 112
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg gagagagtgc     3180

agcccctgga ggagaacgtg ggcaacgccg ccagacccag attcgagaga aacaagctgc     3240

tgctggtggc cagcgtgatc cagggcctgg gcctgctgct gtgcttcacc tacatctgcc     3300

tgcacttcag cgccctgcag gtgagccaca gataccccag aatccagagc atcaaggtgc     3360

agttcaccga gtacaagaag gagaagggct tcatcctgac cagccagaag gaggacgaga     3420

tcatgaaggt gcagaacaac agcgtgatca tcaactgcga cggcttctac ctgatcagcc     3480

tgaagggcta cttcagccag gaggtgaaca tcagcctgca ctaccagaag gacgaggagc     3540

ccctgttcca gctgaagaag gtgagaagcg tgaacagcct gatggtggcc agcctgacct     3600

acaaggacaa ggtgtacctg aacgtgacca ccgacaacac cagcctggac gacttccacg     3660

tgaacggcgg cgagctgatc ctgatccacc agaaccccgg cgagttctgc gtgctgtaaa     3720

cccagctttc ttgtacaaag tggtgataat cgaattccga taatcaacct ctggattaca     3780

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     3840

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     3900

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     3960

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     4020

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     4080

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     4140

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     4200

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     4260

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     4320

gtcggatctc cctttgggcc gcctccccgc atcgggaatt cccgcggttc gctttaagac     4380

caatgactta caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg     4440

aagggctaat tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct     4500

ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc     4560

ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg     4620

gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc agtagtagtt     4680

catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga     4740

ggaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     4800

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     4860

cttatcatgt ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc     4920

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     4980

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     5040

agggacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt     5100

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat     5160

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     5220

ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt     5280

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     5340

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     5400

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     5460

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     5520

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     5580

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     5640

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt     5700

taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     5760

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     5820

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     5880

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     5940

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     6000

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     6060

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     6120

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     6180

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     6240

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     6300

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     6360

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     6420

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     6480

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     6540

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     6600

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     6660

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     6720

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     6780

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     6840

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     6900

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     6960

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     7020

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     7080

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     7140

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     7200

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     7260

aaagcgccac gcttcccgaa gagagaaagg cggacaggta tccggtaagc ggcagggtcg     7320

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     7380

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     7440

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     7500

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     7560

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     7620

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     7680

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     7740

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     7800

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     7860

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagctt        7917


<210> 113
<211> 7947
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 113
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg cccgaggagg     3180

gcagcggctg cagcgtgaga agaagaccct acggctgcgt gctgagagcc gccctggtgc     3240

ccctggtggc cggcctggtg atctgcctgg tggtgtgcat ccagagattc gcccaggccc     3300

agcagcagct gcccctggag agcctgggct gggacgtggc cgagctgcag ctgaaccaca     3360

ccggccccca gcaggacccc agactgtact ggcagggcgg ccccgccctg ggcagaagct     3420

tcctgcacgg ccccgagctg gacaagggcc agctgagaat ccacagagac ggcatctaca     3480

tggtgcacat ccaggtgacc ctggccatct gcagcagcac caccgccagc agacaccacc     3540

ccaccaccct ggccgtgggc atctgcagcc ccgccagcag aagcatcagc ctgctgagac     3600

tgagcttcca ccagggctgc accatcgcca gccagagact gacccccctg gccagaggcg     3660

acaccctgtg caccaacctg accggcaccc tgctgcccag cagaaacacc gacgagacct     3720

tcttcggcgt gcagtgggtg agaccctaaa cccagctttc ttgtacaaag tggtgataat     3780

cgaattccga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     3840

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     3900

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     3960

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     4020

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     4080

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     4140

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc     4200

catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     4260

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     4320

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     4380

atcgggaatt cccgcggttc gctttaagac caatgactta caaggcagct gtagatctta     4440

gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag     4500

atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct     4560

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag     4620

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt     4680

cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag tatttataac     4740

ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt     4800

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4860

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc     4920

cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg     4980

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca     5040

gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag     5100

tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     5160

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     5220

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg     5280

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     5340

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     5400

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     5460

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     5520

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     5580

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     5640

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5700

aattttaaca aaatattaac gcttacaatt taggtggcac ttttcgggga aatgtgcgcg     5760

gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat     5820

aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc     5880

gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa     5940

cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac     6000

tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga     6060

tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag     6120

agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca     6180

cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca     6240

tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa     6300

ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc     6360

tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa     6420

cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag     6480

actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct     6540

ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac     6600

tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa     6660

ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt     6720

aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat     6780

ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg     6840

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc     6900

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg     6960

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag     7020

cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact     7080

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg     7140

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc     7200

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg     7260

aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gagagaaagg     7320

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag     7380

ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc     7440

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct     7500

ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc     7560

ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc     7620

gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac     7680

cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact     7740

ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc     7800

aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat     7860

ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac cctcactaaa     7920

gggaacaaaa gctggagctg caagctt                                         7947


<210> 114
<211> 10051
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 114
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtatca actttgtata gaaaagttgg gctccggtgc ccgtcagtgg gcagagcgca     1980

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga     2040

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg     2100

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg     2160

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta     2220

cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac gtgattcttg     2280

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc     2340

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct     2400

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt     2460

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc     2520

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc     2580

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt     2640

ctcaagctgg ccggcctgct ctggtgcctg gtctcgcgcc gccgtgtatc gccccgccct     2700

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg     2760

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt     2820

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     2880

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     2940

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     3000

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     3060

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     3120

tgtcgtgaca agtttgtaca aaaaagcagg ctgccaccat gggccacacc agaagacagg     3180

gcaccagccc cagcaagtgc ccctacctga acttcttcca gctgctggtg ctggccggcc     3240

tgagccactt ctgcagcggc gtgatccacg tgaccaagga ggtgaaggag gtggccaccc     3300

tgagctgcgg ccacaacgtg agcgtggagg agctggccca gaccagaatc tactggcaga     3360

aggagaagaa gatggtgctg accatgatga gcggcgacat gaacatctgg cccgagtaca     3420

agaacagaac catcttcgac atcaccaaca acctgagcat cgtgatcctg gccctgagac     3480

ccagcgacga gggcacctac gagtgcgtgg tgctgaagta cgagaaggac gccttcaaga     3540

gagagcacct ggccgaggtg accctgagcg tgaaggccga cttccccacc cccagcatca     3600

gcgacttcga gatccccacc agcaacatca gaagaatcat ctgcagcacc agcggcggct     3660

tccccgagcc ccacctgagc tggctggaga acggcgagga gctgaacgcc atcaacacca     3720

ccgtgagcca ggaccccgag accgagctgt acgccgtgag cagcaagctg gacttcaaca     3780

tgaccaccaa ccacagcttc atgtgcctga tcaagtacgg ccacctgaga gtgaaccaga     3840

ccttcaactg gaacaccacc aagcaggagc acttccccga caacctgctg cccagctggg     3900

ccatcaccct gatcagcgtg aacggcatct tcgtgatctg ctgcctgacc tactgcttcg     3960

cccccagatg cagagagaga agaagaaacg agagactgag aagagagagc gtgagacccg     4020

tgtaaataga tagaacaaca acaattgcat tcatttttga tttcaggttc agggggaggt     4080

gtgggaggtt ttttaaagca agtaaaacct ctacactgac ggtacgcgtt aacaacaaca     4140

attgcattca tttgtagttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt     4200

taaacctcta aaatagtggt acgcgttacc cagctttctt gtacaaagtg gacccagctt     4260

tcttgtacaa agtgggcccc tctccctccc ccccccctaa cgttactggc cgaagccgct     4320

tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg     4380

gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt     4440

cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg     4500

aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac     4560

ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg     4620

cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct     4680

caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg     4740

atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag     4800

gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca     4860

accatggcca ccgtgctggc ccccgcctgg agccccacca cctacctgct gctgctgctg     4920

ctgctgagca gcggcctgag cgcccccctg aagatccagg cctacttcaa cgagaccgcc     4980

gacctgccct gccagttcgc caacagccag aaccagagcc tgagcgagct ggtggtgttc     5040

tggcaggacc aggagaacct ggtgctgaac gaggtgtacc tgggcaagga gaagttcgac     5100

agcgtgcaca gcaagtacat gggcagaacc agcttcgaca gcgacagctg gaccctgaga     5160

ctgcacaacc tgcagatcaa ggacaagggc ctgtaccagt gcatcatcca ccacaagaag     5220

cccaccggca tgatcagaat ccaccagatg aacagcgagc tgagcgtgct ggccaacttc     5280

agccagcccg agatcgtgcc catcagcaac atcaccgaga acgtgtacat caacctgacc     5340

tgcagcagca tccacggcta ccccgagccc aagaagatga gcgtgctgct gagaaccaag     5400

aacagcacca tcgagtacga cggcgtgatg cagaagagcc aggacaacgt gaccgagctg     5460

tacgacgtga gcatcagcct gagcgtgagc ttccccgacg tgaccagcaa catgaccatc     5520

ttctgcatcc tggagaccga caagaccaga ctgctgagca gccccttcag catcgagctg     5580

gaggaccccc agcccccccc cgaccacatc ccctggatca ccgccgtgct gcccaccgtg     5640

atcatctgcg tgatggtgtt ctgcctgatc ctgtggaagt ggaagaagaa gaagagaccc     5700

agaaacagct acaagtgcgg caccaacacc atggagagag aggagagcga gcagaccaag     5760

aagagagaga agatccacat ccccgagaga agcgacgagg cccagagagt gttcaagagc     5820

agcaagacca gcagctgcga caagagcgac acctgcttct aacaacttta ttatacatag     5880

ttgatcaatt ccgataatca acctctggat tacaaaattt gtgaaagatt gactggtatt     5940

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     6000

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     6060

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     6120

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     6180

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     6240

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc     6300

tttccatggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     6360

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     6420

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     6480

ccgcatcggg aattcccgcg gttcgcttta agaccaatga cttacaaggc agctgtagat     6540

cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc ccaacgaaga     6600

caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg agcctgggag     6660

ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt     6720

caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt     6780

tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc atcttattat tcagtattta     6840

taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc agcttataat     6900

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat     6960

tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct ctagctatcc     7020

cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc     7080

atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat     7140

tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt cgccctatag     7200

tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact gggaaaaccc     7260

tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag     7320

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggga     7380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc     7440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac     7500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag     7560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc     7620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg     7680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata     7740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa     7800

cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg gggaaatgtg     7860

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     7920

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     7980

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     8040

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     8100

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     8160

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg     8220

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     8280

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     8340

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     8400

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     8460

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca     8520

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     8580

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     8640

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     8700

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     8760

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     8820

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     8880

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     8940

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     9000

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     9060

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     9120

agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag     9180

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     9240

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     9300

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     9360

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagagaga     9420

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     9480

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     9540

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     9600

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     9660

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     9720

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc     9780

aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc     9840

gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca     9900

ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa     9960

caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat taaccctcac    10020

taaagggaac aaaagctgga gctgcaagct t                                   10051


