
                                SEQUENCE LISTING

<110> Salem, Aliasger K.
      Martin, James A.
      Chakka, Leela Raghava Jaidev
      Quarterman, Juliana C.
      Zheng, Hongjun
      Seol, Dong Rim
      University of Iowa Research Foundation

<120> FORMULATION FOR DELIVERY OF LUBRICIN GENE

<130> 875.201WO1

<140> PCT/US2020/057750   
<141> 2020-10-28  

<150> US 62/926,872       
<151> 2019-10-28  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1404
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 1
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly
            20                  25                  30
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr
        35                  40                  45
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys
    50                  55                  60
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg
65                  70                  75                  80
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys
                85                  90                  95
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser
            100                 105                 110
Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr
        115                 120                 125
Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys
    130                 135                 140
Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val
145                 150                 155                 160
Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
                165                 170                 175
Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg
            180                 185                 190
Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr
        195                 200                 205
Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser
    210                 215                 220
Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr
225                 230                 235                 240
Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys
                245                 250                 255
Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys
            260                 265                 270
Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu
        275                 280                 285
Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr
    290                 295                 300
Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp
305                 310                 315                 320
Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu
                325                 330                 335
Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro
            340                 345                 350
Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro
        355                 360                 365
Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
    370                 375                 380
Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
385                 390                 395                 400
Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
                405                 410                 415
Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro
            420                 425                 430
Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro
        435                 440                 445
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro
    450                 455                 460
Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys
465                 470                 475                 480
Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys
                485                 490                 495
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
            500                 505                 510
Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
        515                 520                 525
Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser
    530                 535                 540
Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro
545                 550                 555                 560
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro
                565                 570                 575
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
            580                 585                 590
Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro
        595                 600                 605
Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu
    610                 615                 620
Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro
625                 630                 635                 640
Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro
                645                 650                 655
Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala
            660                 665                 670
Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
        675                 680                 685
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr
    690                 695                 700
Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro
705                 710                 715                 720
Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr
                725                 730                 735
Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr
            740                 745                 750
Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
        755                 760                 765
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr
    770                 775                 780
Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys
785                 790                 795                 800
Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp
                805                 810                 815
Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys
            820                 825                 830
Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu
        835                 840                 845
Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys
    850                 855                 860
Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu
865                 870                 875                 880
Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro
                885                 890                 895
Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr
            900                 905                 910
Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro
        915                 920                 925
Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr
    930                 935                 940
Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val
945                 950                 955                 960
Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu
                965                 970                 975
Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile
            980                 985                 990
Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys
        995                 1000                1005
Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro
    1010                1015                1020
Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys Lys Pro Lys Thr Met
1025                1030                1035                1040
Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr Pro Arg Lys Met Thr
                1045                1050                1055
Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala Glu Ala Met
            1060                1065                1070
Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro Asn Ser Lys Leu Val
        1075                1080                1085
Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr
    1090                1095                1100
Pro His Met Leu Leu Arg Pro His Val Phe Met Pro Glu Val Thr Pro
1105                1110                1115                1120
Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln Gly Ile Ile Ile Asn
                1125                1130                1135
Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn Gly Lys Pro Val Asp
            1140                1145                1150
Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val Ala Phe Arg Gly His
        1155                1160                1165
Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg
    1170                1175                1180
Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile Asp Thr Val Phe Thr
1185                1190                1195                1200
Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr
                1205                1210                1215
Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile
            1220                1225                1230
Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile Val Ala Ala Leu Ser
        1235                1240                1245
Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg
    1250                1255                1260
Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys
1265                1270                1275                1280
Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro Val Tyr Gly Glu Thr
                1285                1290                1295
Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln
            1300                1305                1310
Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln
        1315                1320                1325
Asp Lys Gly Val Leu His Asn Glu Val Lys Val Ser Ile Leu Trp Arg
    1330                1335                1340
Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg
1345                1350                1355                1360
Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr
                1365                1370                1375
Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser
            1380                1385                1390
Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro
        1395                1400

<210> 2
<211> 1311
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 2
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly
            20                  25                  30
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr
        35                  40                  45
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys
    50                  55                  60
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg
65                  70                  75                  80
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys
                85                  90                  95
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val Lys Asp Asn Lys Lys
            100                 105                 110
Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu
        115                 120                 125
Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp
    130                 135                 140
Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr
145                 150                 155                 160
Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp
                165                 170                 175
Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu
            180                 185                 190
Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys
        195                 200                 205
Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser
    210                 215                 220
Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro
225                 230                 235                 240
Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu
                245                 250                 255
Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu
            260                 265                 270
Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro
        275                 280                 285
Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala
    290                 295                 300
Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala
305                 310                 315                 320
Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro
                325                 330                 335
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro
            340                 345                 350
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro
        355                 360                 365
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr
    370                 375                 380
Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr
385                 390                 395                 400
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
                405                 410                 415
Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
            420                 425                 430
Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr
        435                 440                 445
Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr
    450                 455                 460
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro
465                 470                 475                 480
Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro
                485                 490                 495
Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro
            500                 505                 510
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro
        515                 520                 525
Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro
    530                 535                 540
Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro
545                 550                 555                 560
Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro
                565                 570                 575
Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro
            580                 585                 590
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro
        595                 600                 605
Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu
    610                 615                 620
Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu
625                 630                 635                 640
Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp Lys Pro
                645                 650                 655
Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro
            660                 665                 670
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr
        675                 680                 685
Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro
    690                 695                 700
Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr
705                 710                 715                 720
Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr
                725                 730                 735
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr
            740                 745                 750
Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr
        755                 760                 765
Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr
    770                 775                 780
Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro
785                 790                 795                 800
Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro
                805                 810                 815
Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg
            820                 825                 830
Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr
        835                 840                 845
Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr
    850                 855                 860
Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile
865                 870                 875                 880
Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys
                885                 890                 895
Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu Thr Ala
            900                 905                 910
Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro Lys Pro
        915                 920                 925
Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys Lys Pro
    930                 935                 940
Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr Pro Arg
945                 950                 955                 960
Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala
                965                 970                 975
Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro Asn Ser
            980                 985                 990
Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly Ala Glu
        995                 1000                1005
Gly Glu Thr Pro His Met Leu Leu Arg Pro His Val Phe Met Pro Glu
    1010                1015                1020
Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln Gly Ile
1025                1030                1035                1040
Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn Gly Lys
                1045                1050                1055
Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val Ala Phe
            1060                1065                1070
Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro Ser Pro
        1075                1080                1085
Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile Asp Thr
    1090                1095                1100
Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe Lys Asp
1105                1110                1115                1120
Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro
                1125                1130                1135
Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile Val Ala
            1140                1145                1150
Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val Tyr Phe
        1155                1160                1165
Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln Glu Pro
    1170                1175                1180
Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro Val Tyr
1185                1190                1195                1200
Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly
                1205                1210                1215
Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala Arg Leu
            1220                1225                1230
Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu Val Lys Val Ser Ile
        1235                1240                1245
Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser Leu Pro
    1250                1255                1260
Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp
1265                1270                1275                1280
Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr
                1285                1290                1295
Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro
            1300                1305                1310

<210> 3
<211> 1270
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 3
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15
Phe Val Ile Gln Gln Val Ser Ser Gln Glu Leu Ser Cys Lys Gly Arg
            20                  25                  30
Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala Gln
        35                  40                  45
Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys Ala
    50                  55                  60
Glu Val Lys Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro
65                  70                  75                  80
Lys Pro Pro Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp
                85                  90                  95
Phe Lys Val Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val
            100                 105                 110
Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro
        115                 120                 125
Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val
    130                 135                 140
Asn Lys Glu Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys
145                 150                 155                 160
Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr
                165                 170                 175
Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys
            180                 185                 190
Val Leu Ala Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro
        195                 200                 205
Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro
    210                 215                 220
Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala
225                 230                 235                 240
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro
                245                 250                 255
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro
            260                 265                 270
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro
        275                 280                 285
Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
    290                 295                 300
Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
305                 310                 315                 320
Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
                325                 330                 335
Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala
            340                 345                 350
Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
        355                 360                 365
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr
    370                 375                 380
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr
385                 390                 395                 400
Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys
                405                 410                 415
Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys
            420                 425                 430
Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys
        435                 440                 445
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
    450                 455                 460
Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys
465                 470                 475                 480
Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu
                485                 490                 495
Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu
            500                 505                 510
Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu
        515                 520                 525
Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys
    530                 535                 540
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys
545                 550                 555                 560
Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys
                565                 570                 575
Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys
            580                 585                 590
Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr
        595                 600                 605
Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala
    610                 615                 620
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala
625                 630                 635                 640
Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala
                645                 650                 655
Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr
            660                 665                 670
Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr
        675                 680                 685
Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
    690                 695                 700
Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr
705                 710                 715                 720
Ser Glu Val Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His
                725                 730                 735
Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro
            740                 745                 750
Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys
        755                 760                 765
Thr Pro Ala Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys
    770                 775                 780
Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala
785                 790                 795                 800
Pro Lys Met Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu
                805                 810                 815
Ser Lys Ile Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln
            820                 825                 830
Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala
        835                 840                 845
Pro Lys Val Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met
    850                 855                 860
Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser
865                 870                 875                 880
Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys
                885                 890                 895
Pro Thr Ser Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro
            900                 905                 910
Lys Thr Thr Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu
        915                 920                 925
Asn Pro Thr Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg
    930                 935                 940
Pro Asn Gln Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser
945                 950                 955                 960
Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg
                965                 970                 975
Pro His Val Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro
            980                 985                 990
Arg Val Pro Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu
        995                 1000                1005
Thr Asn Ile Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg
    1010                1015                1020
Asn Gly Thr Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser
1025                1030                1035                1040
Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly
                1045                1050                1055
Ile Pro Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly
            1060                1065                1070
Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp
        1075                1080                1085
Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly
    1090                1095                1100
Leu Thr Gly Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn
1105                1110                1115                1120
Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln
                1125                1130                1135
Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro
            1140                1145                1150
Ala Leu Asn Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg
        1155                1160                1165
Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile
    1170                1175                1180
Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His
1185                1190                1195                1200
Asn Glu Val Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val
                1205                1210                1215
Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp
            1220                1225                1230
Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser
        1235                1240                1245
Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys
    1250                1255                1260
Val Trp Tyr Asn Cys Pro
1265                1270

<210> 4
<211> 1404
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 4
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly
            20                  25                  30
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr
        35                  40                  45
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys
    50                  55                  60
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg
65                  70                  75                  80
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys
                85                  90                  95
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser
            100                 105                 110
Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr
        115                 120                 125
Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys
    130                 135                 140
Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val
145                 150                 155                 160
Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
                165                 170                 175
Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg
            180                 185                 190
Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr
        195                 200                 205
Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser
    210                 215                 220
Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr
225                 230                 235                 240
Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys
                245                 250                 255
Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys
            260                 265                 270
Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu
        275                 280                 285
Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr
    290                 295                 300
Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp
305                 310                 315                 320
Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu
                325                 330                 335
Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro
            340                 345                 350
Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro
        355                 360                 365
Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
    370                 375                 380
Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
385                 390                 395                 400
Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
                405                 410                 415
Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro
            420                 425                 430
Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro
        435                 440                 445
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro
    450                 455                 460
Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys
465                 470                 475                 480
Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys
                485                 490                 495
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
            500                 505                 510
Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
        515                 520                 525
Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser
    530                 535                 540
Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro
545                 550                 555                 560
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro
                565                 570                 575
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
            580                 585                 590
Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro
        595                 600                 605
Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu
    610                 615                 620
Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro
625                 630                 635                 640
Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro
                645                 650                 655
Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala
            660                 665                 670
Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
        675                 680                 685
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr
    690                 695                 700
Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro
705                 710                 715                 720
Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr
                725                 730                 735
Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr
            740                 745                 750
Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
        755                 760                 765
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr
    770                 775                 780
Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys
785                 790                 795                 800
Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp
                805                 810                 815
Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys
            820                 825                 830
Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu
        835                 840                 845
Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys
    850                 855                 860
Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu
865                 870                 875                 880
Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro
                885                 890                 895
Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr
            900                 905                 910
Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro
        915                 920                 925
Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr
    930                 935                 940
Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val
945                 950                 955                 960
Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu
                965                 970                 975
Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile
            980                 985                 990
Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys
        995                 1000                1005
Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro
    1010                1015                1020
Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys Lys Pro Lys Thr Met
1025                1030                1035                1040
Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr Pro Arg Lys Met Thr
                1045                1050                1055
Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala Glu Ala Met
            1060                1065                1070
Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro Asn Ser Lys Leu Val
        1075                1080                1085
Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr
    1090                1095                1100
Pro His Met Leu Leu Arg Pro His Val Phe Met Pro Glu Val Thr Pro
1105                1110                1115                1120
Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln Gly Ile Ile Ile Asn
                1125                1130                1135
Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn Gly Lys Pro Val Asp
            1140                1145                1150
Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val Ala Phe Arg Gly His
        1155                1160                1165
Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg
    1170                1175                1180
Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile Asp Thr Val Phe Thr
1185                1190                1195                1200
Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr
                1205                1210                1215
Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile
            1220                1225                1230
Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile Val Ala Ala Leu Ser
        1235                1240                1245
Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg
    1250                1255                1260
Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys
1265                1270                1275                1280
Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro Val Tyr Gly Glu Thr
                1285                1290                1295
Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln
            1300                1305                1310
Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln
        1315                1320                1325
Asp Lys Gly Val Leu His Asn Glu Val Lys Val Ser Ile Leu Trp Arg
    1330                1335                1340
Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg
1345                1350                1355                1360
Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr
                1365                1370                1375
Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser
            1380                1385                1390
Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro
        1395                1400

<210> 5
<211> 1361
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 5
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly
            20                  25                  30
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr
        35                  40                  45
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys
    50                  55                  60
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg
65                  70                  75                  80
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys
                85                  90                  95
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser
            100                 105                 110
Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr
        115                 120                 125
Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys
    130                 135                 140
Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Val Lys Asp Asn
145                 150                 155                 160
Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val
                165                 170                 175
Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr
            180                 185                 190
Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys
        195                 200                 205
Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn
    210                 215                 220
Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr
225                 230                 235                 240
Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp
                245                 250                 255
Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys
            260                 265                 270
Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro
        275                 280                 285
Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro
    290                 295                 300
Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro
305                 310                 315                 320
Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys
                325                 330                 335
Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu
            340                 345                 350
Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu
        355                 360                 365
Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser
    370                 375                 380
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro
385                 390                 395                 400
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
                405                 410                 415
Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala
            420                 425                 430
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala
        435                 440                 445
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala
    450                 455                 460
Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala
465                 470                 475                 480
Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro
                485                 490                 495
Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr
            500                 505                 510
Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
        515                 520                 525
Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
    530                 535                 540
Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr
545                 550                 555                 560
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr
                565                 570                 575
Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr
            580                 585                 590
Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr
        595                 600                 605
Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr
    610                 615                 620
Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr
625                 630                 635                 640
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
                645                 650                 655
Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr
            660                 665                 670
Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys
        675                 680                 685
Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp
    690                 695                 700
Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys
705                 710                 715                 720
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys
                725                 730                 735
Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys
            740                 745                 750
Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr
        755                 760                 765
Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala
    770                 775                 780
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala
785                 790                 795                 800
Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr
                805                 810                 815
Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu
            820                 825                 830
Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn
        835                 840                 845
Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr
    850                 855                 860
Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp
865                 870                 875                 880
Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys
                885                 890                 895
Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala
            900                 905                 910
Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe
        915                 920                 925
Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr
    930                 935                 940
Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu
945                 950                 955                 960
Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro
                965                 970                 975
Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys
            980                 985                 990
Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr
        995                 1000                1005
Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg
    1010                1015                1020
Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro
1025                1030                1035                1040
Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly
                1045                1050                1055
Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg Pro His Val Phe Met
            1060                1065                1070
Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln
        1075                1080                1085
Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn
    1090                1095                1100
Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val
1105                1110                1115                1120
Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro
                1125                1130                1135
Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile
            1140                1145                1150
Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe
        1155                1160                1165
Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly
    1170                1175                1180
Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile
1185                1190                1195                1200
Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val
                1205                1210                1215
Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln
            1220                1225                1230
Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro
        1235                1240                1245
Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala
    1250                1255                1260
Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala
1265                1270                1275                1280
Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu Val Lys Val
                1285                1290                1295
Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser
            1300                1305                1310
Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser
        1315                1320                1325
Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala
    1330                1335                1340
Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys
1345                1350                1355                1360
Pro


<210> 6
<211> 1363
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 6
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15
Phe Val Ile Gln Gln Val Ser Ser Gln Glu Leu Ser Cys Lys Gly Arg
            20                  25                  30
Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala Gln
        35                  40                  45
Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys Ala
    50                  55                  60
Glu Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Lys Ala Pro Pro
65                  70                  75                  80
Pro Ser Gly Ala Ser Gln Thr Ile Lys Ser Thr Thr Lys Arg Ser Pro
                85                  90                  95
Lys Pro Pro Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu Glu
            100                 105                 110
Ile Thr Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser Ser
        115                 120                 125
Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Ile Lys Ser Ser
    130                 135                 140
Lys Asn Ser Ala Ala Asn Arg Glu Leu Gln Lys Lys Leu Lys Val Lys
145                 150                 155                 160
Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro
                165                 170                 175
Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val
            180                 185                 190
Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser
        195                 200                 205
Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro
    210                 215                 220
Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu
225                 230                 235                 240
Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser
                245                 250                 255
Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile
            260                 265                 270
Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala
        275                 280                 285
Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr
    290                 295                 300
Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr
305                 310                 315                 320
Thr Pro Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr
                325                 330                 335
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro
            340                 345                 350
Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro
        355                 360                 365
Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr
    370                 375                 380
Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys
385                 390                 395                 400
Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys
                405                 410                 415
Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys Glu
            420                 425                 430
Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys Lys
        435                 440                 445
Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu
    450                 455                 460
Pro Ala Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys Glu
465                 470                 475                 480
Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu Pro
                485                 490                 495
Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ser
            500                 505                 510
Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala
        515                 520                 525
Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala
    530                 535                 540
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro Ala
545                 550                 555                 560
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala
                565                 570                 575
Pro Thr Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu Ala
            580                 585                 590
Pro Thr Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu Ala
        595                 600                 605
Pro Thr Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro Ala
    610                 615                 620
Pro Thr Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro Ala
625                 630                 635                 640
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala
                645                 650                 655
Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr Ala
            660                 665                 670
Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala
        675                 680                 685
Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr Thr
    690                 695                 700
Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr
705                 710                 715                 720
Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
                725                 730                 735
Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr
            740                 745                 750
Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Gly
        755                 760                 765
Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Glu
    770                 775                 780
Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys
785                 790                 795                 800
Pro Ala Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu Val
                805                 810                 815
Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser Pro
            820                 825                 830
Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala Leu
        835                 840                 845
Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro Ala
    850                 855                 860
Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu
865                 870                 875                 880
Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys Met
                885                 890                 895
Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys Ile
            900                 905                 910
Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr Thr
        915                 920                 925
Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys Val
    930                 935                 940
Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys Pro
945                 950                 955                 960
Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala Thr
                965                 970                 975
Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr Ser
            980                 985                 990
Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr Thr
        995                 1000                1005
Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr
    1010                1015                1020
Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn Gln
1025                1030                1035                1040
Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp Ala
                1045                1050                1055
Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg Pro His Val
            1060                1065                1070
Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val Pro
        1075                1080                1085
Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn Ile
    1090                1095                1100
Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly Thr
1105                1110                1115                1120
Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe Ser
                1125                1130                1135
Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro Ser
            1140                1145                1150
Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr Phe
        1155                1160                1165
Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys Asp
    1170                1175                1180
Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr Gly
1185                1190                1195                1200
Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro Glu
                1205                1210                1215
Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile Tyr
            1220                1225                1230
Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu Asn
        1235                1240                1245
Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe Glu
    1250                1255                1260
Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr Ser
1265                1270                1275                1280
Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu Val
                1285                1290                1295
Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser Ala
            1300                1305                1310
Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala
        1315                1320                1325
Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr Ala
    1330                1335                1340
Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp Tyr
1345                1350                1355                1360
Asn Cys Pro

