﻿                         序列表

<110>  北京大学

<120>  CRISPR家族蛋白与核酸的定点偶联方法及其偶联物和用途

<130>  182010593

<150>  CN201911092554.8
<151>  2019-11-11

<160>  7

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes strain SF370

<400>  1
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      
Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          
Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              
Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  
Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  
Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      
Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         
His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             
His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 
Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 
Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     
Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         
Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             
Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 
Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 
Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     
Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         
Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             
Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 
Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 
Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     
Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         
Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             
Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 
Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 
Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     
Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         
Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             
Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 
Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 
Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     
Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         
Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             
Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 
Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 
Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     
Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         
Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             
Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 
Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 
His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     
Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         
Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             
Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 
Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 
His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     
Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         
Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             
Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 
Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 
Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     
Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         
Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             
Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 
Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 
Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     
Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         
Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             
Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 
Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 
Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     
Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         
Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             
Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys 
    1010                 1015                 1020                 
Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  
1025                 1030                 1035                 1040 
Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu 
                1045                 1050                 1055     
Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile 
            1060                 1065                 1070         
Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
        1075                 1080                 1085             
Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly 
    1090                 1095                 1100                 
Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  
1105                 1110                 1115                 1120 
Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser 
                1125                 1130                 1135     
Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly 
            1140                 1145                 1150         
Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
        1155                 1160                 1165             
Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala 
    1170                 1175                 1180                 
Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  
1185                 1190                 1195                 1200 
Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser 
                1205                 1210                 1215     
Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr 
            1220                 1225                 1230         
Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
        1235                 1240                 1245             
Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His 
    1250                 1255                 1260                 
Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  
1265                 1270                 1275                 1280 
Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys 
                1285                 1290                 1295     
His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu 
            1300                 1305                 1310         
Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
        1315                 1320                 1325             
Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp 
    1330                 1335                 1340                 
Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  
1345                 1350                 1355                 1360 
Asp Leu Ser Gln Leu  Gly Gly Asp 
                1365             

<210>  2
<211>  4104
<212>  DNA
<213>  Streptococcus pyogenes strain SF370

<400>  2
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc        60
attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc       120
cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa       180
gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc       240
tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg       300
ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc       360
aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag       420
aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat       480
atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat       540
gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg       600
atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg       660
cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat       720
cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa       780
gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc       840
cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt       900
ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt       960
atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga      1020
cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc      1080
ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg      1140
gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc      1200
aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac      1260
gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt      1320
gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc      1380
agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa      1440
gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa      1500
aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt      1560
tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg      1620
tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc      1680
gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc      1740
agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc      1800
attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc      1860
ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct      1920
catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg      1980
cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg      2040
gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac      2100
tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt      2160
cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc      2220
gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt      2280
atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg      2340
atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca      2400
gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg      2460
gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat      2520
atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc      2580
gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa      2640
aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg      2700
actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag      2760
cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac      2820
accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct      2880
aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat      2940
taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa      3000
tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa      3060
atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc      3120
aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga      3180
ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc      3240
gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta      3300
cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc      3360
gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct      3420
tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc      3480
aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac      3540
tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag      3600
tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg      3660
cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc      3720
cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa      3780
caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg      3840
atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag      3900
cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg      3960
cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag      4020
gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc      4080
gacctctctc agctcggtgg agac                                             4104

<210>  3
<211>  1227
<212>  PRT
<213>  Acidaminococcus sp BV3L6

<400>  3
Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
1               5                   10                  15      
Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
            20                  25                  30          
Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
        35                  40                  45              
Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
    50                  55                  60                  
Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
65                  70                  75                  80  
Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
                85                  90                  95      
Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
            100                 105                 110         
Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
        115                 120                 125             
Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
    130                 135                 140                 
Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
145                 150                 155                 160 
Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
                165                 170                 175     
Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
            180                 185                 190         
Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
        195                 200                 205             
Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
    210                 215                 220                 
Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
225                 230                 235                 240 
Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
                245                 250                 255     
Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
            260                 265                 270         
Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
        275                 280                 285             
Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
    290                 295                 300                 
Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
305                 310                 315                 320 
Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
                325                 330                 335     
Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
            340                 345                 350         
Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
        355                 360                 365             
His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
    370                 375                 380                 
Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
385                 390                 395                 400 
Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
                405                 410                 415     
Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
            420                 425                 430         
Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
        435                 440                 445             
Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
    450                 455                 460                 
Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
465                 470                 475                 480 
Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
                485                 490                 495     
Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
            500                 505                 510         
Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
        515                 520                 525             
Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
    530                 535                 540                 
Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
545                 550                 555                 560 
Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
                565                 570                 575     
Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
            580                 585                 590         
Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
        595                 600                 605             
Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
    610                 615                 620                 
Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
625                 630                 635                 640 
Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
                645                 650                 655     
Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
            660                 665                 670         
Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
        675                 680                 685             
Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
    690                 695                 700                 
Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
705                 710                 715                 720 
Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
                725                 730                 735     
Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
            740                 745                 750         
Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
        755                 760                 765             
Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr Lys 
    770                 775                 780                 
Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile Ala 
785                 790                 795                 800 
Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val Arg 
                805                 810                 815     
Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg 
            820                 825                 830         
Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly Asn 
        835                 840                 845             
Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn Gly 
    850                 855                 860                 
Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu Lys 
865                 870                 875                 880 
Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile Lys 
                885                 890                 895     
Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys Glu 
            900                 905                 910         
Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser 
        915                 920                 925             
Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln Lys 
    930                 935                 940                 
Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys Lys 
945                 950                 955                 960 
Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile Thr 
                965                 970                 975     
Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe Ile 
            980                 985                 990         
Phe Tyr Ile Pro Ala Trp Leu Thr  Ser Lys Ile Asp Pro  Ser Thr Gly 
        995                 1000                 1005             
Phe Val  Asn Leu Leu Lys Thr  Lys Tyr Thr Ser Ile  Ala Asp Ser Lys 
    1010                 1015                 1020                 
Lys  Phe Ile Ser Ser Phe  Asp Arg Ile Met Tyr  Val Pro Glu Glu Asp  
1025                 1030                 1035                 1040 
Leu Phe Glu Phe Ala  Leu Asp Tyr Lys Asn  Phe Ser Arg Thr Asp  Ala 
                1045                 1050                 1055     
Asp Tyr Ile Lys  Lys Trp Lys Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg 
            1060                 1065                 1070         
Ile Phe Arg  Asn Pro Lys Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val 
        1075                 1080                 1085             
Cys Leu  Thr Ser Ala Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile Asn 
    1090                 1095                 1100                 
Tyr  Gln Gln Gly Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser Asp Lys  
1105                 1110                 1115                 1120 
Ala Phe Tyr Ser Ser  Phe Met Ala Leu Met  Ser Leu Met Leu Gln  Met 
                1125                 1130                 1135     
Arg Asn Ser Ile  Thr Gly Arg Thr Asp  Val Asp Phe Leu Ile  Ser Pro 
            1140                 1145                 1150         
Val Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser Arg Asn  Tyr Glu Ala 
        1155                 1160                 1165             
Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala Asp Ala  Asn Gly Ala Tyr 
    1170                 1175                 1180                 
Asn  Ile Ala Arg Lys Val  Leu Trp Ala Ile Gly  Gln Phe Lys Lys Ala  
1185                 1190                 1195                 1200 
Glu Asp Glu Lys Leu  Asp Lys Val Lys Ile  Ala Ile Ser Asn Lys  Glu 
                1205                 1210                 1215     
Trp Leu Glu Tyr  Ala Gln Thr Ser Val  Lys His 
            1220                 1225         

<210>  4
<211>  3681
<212>  DNA
<213>  Acidaminococcus sp BV3L6

<400>  4
tcaaagctcg agaaattcac caactgttat tcgttgagca aaacactgcg gtttaaagcg        60
attccagtcg gcaagactca agagaatata gacaataagc ggctgttggt ggaagatgaa       120
aagcgcgcgg aagactacaa aggggtgaag aagttgttgg acagatacta cctctctttt       180
atcaatgatg tcttgcactc aatcaaattg aagaatctga acaactacat ctccctcttc       240
agaaagaaaa caaggacaga aaaggagaat aaggaacttg aaaatttgga gatcaatctg       300
aggaaagaga tcgcgaaagc ctttaaaggc aacgaaggat acaaaagtct gttcaagaag       360
gatataattg agacaatttt gccagagttc ctcgatgaca aggacgagat tgcgctggtc       420
aattcgttca acggattcac aacagcattc acaggcttct ttgataatcg ggaaaatatg       480
ttctctgagg aggcaaagtc cacttctatt gcgttcaggt gtatcaatga gaatctcact       540
aggtacattt ccaacatgga tatctttgag aaggttgacg caatttttga caagcacgaa       600
gttcaggaga ttaaggagaa gatcctcaat tccgattatg acgttgagga cttcttcgaa       660
ggtgagtttt ttaatttcgt gctcactcaa gagggtatcg acgtgtataa tgcgatcatc       720
ggtgggttcg tgactgagtc cggtgaaaag attaagggat tgaacgagta tatcaacctt       780
tacaaccaaa agacgaaaca gaagctgcca aagttcaagc ctctttacaa acaggttctt       840
tcagaccgcg agtcactctc gttctatggg gagggctaca cttcggatga ggaagtcctg       900
gaggtgttca ggaatactct caataagaat tcggagattt tctcttctat aaaaaaactg       960
gaaaagttgt ttaagaattt tgacgaatac tctagcgccg gcatatttgt gaaaaacggc      1020
ccggccatat caacgataag taaagatatc ttcggcgaat ggaacgtgat cagagacaaa      1080
tggaacgcgg agtatgacga tattcacctg aagaagaagg ctgtcgtaac ggagaagtac      1140
gaggatgatc gcaggaaaag cttcaaaaag atcggaagtt tcagcctgga acagttgcag      1200
gagtatgctg acgccgatct tagcgtcgtc gagaagttga aggagataat catccaaaag      1260
gtcgacgaga tatataaagt ctatggatca agtgaaaaac tgttcgacgc cgacttcgtt      1320
ttggagaagt ccctgaagaa gaacgacgct gttgttgcca ttatgaagga tctgctcgac      1380
agcgtgaaga gtttcgagaa ctatattaag gcttttttcg gggaggggaa ggagactaac      1440
agagatgagt ccttctacgg agacttcgtc ctcgcgtacg atatactcct taaggtagac      1500
cacatctacg acgcaatcag aaattacgtg acacaaaagc cgtacagcaa ggacaagttc      1560
aaactctact tccagaaccc ccagttcatg ggcggctggg acaaggacaa ggaaacggat      1620
tacagggcta cgatcctgag gtatggttca aaatactact tggcgattat ggacaagaag      1680
tacgccaagt gtctccagaa gattgacaaa gacgatgtca atggcaatta tgagaagatc      1740
aactacaagc tgcttccggg tccgaacaag atgctcccaa aggttttctt cagcaagaaa      1800
tggatggcct actataaccc aagcgaggac atccagaaga tttataagaa cggtacgttc      1860
aagaagggcg acatgttcaa tcttaacgac tgtcacaagc tgatcgactt cttcaaagac      1920
tcaattagcc ggtacccaaa gtggtctaac gcctatgact tcaacttttc ggaaaccgag      1980
aagtacaagg atatagccgg attttataga gaggtggaag agcagggcta caaggtgtca      2040
ttcgagtccg ccagcaagaa ggaagtggac aagctcgtgg aagagggtaa gctctacatg      2100
ttccagattt ataataaaga ctttagcgat aagagccacg ggacacctaa tctccacaca      2160
atgtatttca agctgctctt cgacgagaat aaccacggcc aaatcaggtt gtcaggaggg      2220
gctgaactct tcatgcggcg cgctagcctt aagaaggagg agcttgtagt ccaccctgcg      2280
aatagtccaa ttgcgaataa gaacccggac aatcctaaaa agactacaac attgagctac      2340
gacgtgtaca aggataagag gttttccgag gatcagtacg agctccacat cccgattgcg      2400
atcaacaagt gcccaaagaa tattttcaag ataaacacag aggtgcgtgt actcctgaag      2460
catgacgaca atccttacgt cattgggatt gatcggggcg agaggaacct cctctatatt      2520
gtggtggtgg acgggaaggg gaacatagtc gaacagtact cccttaacga aataattaac      2580
aatttcaacg gcatccgtat caagaccgac taccattcgt tgctggacaa gaaggagaag      2640
gagagatttg aggcgcggca aaattggaca agtatcgaga acatcaagga actcaaagca      2700
ggttatatct ctcaagttgt gcataagata tgcgagctgg ttgagaagta tgacgcagtg      2760
atcgctcttg aggacctcaa ctcgggcttt aagaattcta gagttaaagt ggagaagcag      2820
gtctatcaaa agttcgagaa gatgcttata gataagctca actacatggt cgataagaaa      2880
tcgaacccat gtgccaccgg cggcgcactc aaaggttacc aaataacaaa caaattcgag      2940
tccttcaaat cgatgagtac tcagaatggg ttcatatttt atataccggc gtggcttacg      3000
tctaagatcg acccgtcaac tggttttgtc aacctgttga agacgaaata cacgtccatt      3060
gccgattcga aaaagttcat atctagtttt gatcgtatta tgtacgtccc agaggaagat      3120
cttttcgagt ttgctctcga ctacaaaaac ttttcgcgga ccgatgcgga ttacattaaa      3180
aaatggaaac tctattcgta cggcaacaga atcaggattt ttcgcaaccc taagaagaat      3240
aacgtctttg attgggagga agtttgcttg actagcgcgt acaaggagct ctttaataag      3300
tatggcatta actaccaaca gggtgatatc agagcactgc tttgcgaaca atctgacaag      3360
gctttctact catccttcat ggctttgatg agcctgatgc tccagatgag aaattcaatt      3420
acaggcagaa ccgacgtgga tttcttgatc tccccggtta aaaattctga tggcatcttt      3480
tacgatagca ggaactatga agcgcaagag aatgcgattc tgccaaaaaa tgcagacgcc      3540
aacggtgcct ataacatcgc caggaaagtc ctgtgggcga tcggccagtt caaaaaggcc      3600
gaagacgaaa aattggacaa ggtcaaaatc gctatcagca acaaagagtg gctggagtat      3660
gctcagacat ccgtaaagca t                                                3681

<210>  5
<211>  600
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  5
tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg        60
ggaggtctat ataagcagag ctctctggct aactagagaa cccactgctt actggcttat       120
cgaaattaat acgactcact atagggagac ccaagctggc tagcgtttaa acgggccctc       180
tagactcgag atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt       240
cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga       300
tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc       360
ctggcccacc ctcgtgacca ccctgagcca cggcgtccag tgcttcagcc gctaccccga       420
ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg       480
caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg       540
cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat       600

<210>  6
<211>  1638
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      
Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          
Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              
Asp Gln His Arg Gly Phe Leu His Gln Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  
Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  
Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      
Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         
Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             
Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 
Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 
Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     
Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         
Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             
Glu Ser Ala Thr Pro Glu Ser Met Thr Gln Phe Glu Gly Phe Thr Asn 
    210                 215                 220                 
Leu Tyr Gln Val Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly 
225                 230                 235                 240 
Lys Thr Leu Lys His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys 
                245                 250                 255     
Ala Arg Asn Asp His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile 
            260                 265                 270         
Tyr Lys Thr Tyr Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp 
        275                 280                 285             
Glu Asn Leu Ser Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu 
    290                 295                 300                 
Glu Thr Arg Asn Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala 
305                 310                 315                 320 
Ile His Asp Tyr Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile 
                325                 330                 335     
Asn Lys Arg His Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu 
            340                 345                 350         
Phe Asn Gly Lys Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu 
        355                 360                 365             
His Glu Asn Ala Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe 
    370                 375                 380                 
Ser Gly Phe Tyr Arg Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile 
385                 390                 395                 400 
Ser Thr Ala Ile Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe 
                405                 410                 415     
Lys Glu Asn Cys His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser 
            420                 425                 430         
Leu Arg Glu His Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val 
        435                 440                 445             
Ser Thr Ser Ile Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu 
    450                 455                 460                 
Leu Thr Gln Thr Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile 
465                 470                 475                 480 
Ser Arg Glu Ala Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu 
                485                 490                 495     
Asn Leu Ala Ile Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser 
            500                 505                 510         
Leu Pro His Arg Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg 
        515                 520                 525             
Asn Thr Leu Ser Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val 
    530                 535                 540                 
Ile Gln Ser Phe Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val 
545                 550                 555                 560 
Leu Glu Thr Ala Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu 
                565                 570                 575     
Thr His Ile Phe Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala 
            580                 585                 590         
Leu Cys Asp His Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg 
        595                 600                 605             
Ile Ser Glu Leu Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val 
    610                 615                 620                 
Gln Arg Ser Leu Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser 
625                 630                 635                 640 
Ala Ala Gly Lys Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu 
                645                 650                 655     
Ile Leu Ser His Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr 
            660                 665                 670         
Leu Lys Lys Gln Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser 
        675                 680                 685             
Leu Leu Gly Leu Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser 
    690                 695                 700                 
Asn Glu Val Asp Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu 
705                 710                 715                 720 
Glu Met Glu Pro Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala 
                725                 730                 735     
Thr Lys Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met 
            740                 745                 750         
Pro Thr Leu Ala Arg Gly Trp Asp Val Asn Arg Glu Lys Asn Asn Gly 
        755                 760                 765             
Ala Ile Leu Phe Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro 
    770                 775                 780                 
Lys Gln Lys Gly Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys 
785                 790                 795                 800 
Thr Ser Glu Gly Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala 
                805                 810                 815     
Ala Lys Met Ile Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala 
            820                 825                 830         
His Phe Gln Thr His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile 
        835                 840                 845             
Glu Pro Leu Glu Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu 
    850                 855                 860                 
Lys Glu Pro Lys Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp 
865                 870                 875                 880 
Gln Lys Gly Tyr Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg 
                885                 890                 895     
Asp Phe Leu Ser Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser 
            900                 905                 910         
Leu Arg Pro Ser Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu 
        915                 920                 925             
Leu Asn Pro Leu Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys 
    930                 935                 940                 
Glu Ile Met Asp Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile 
945                 950                 955                 960 
Tyr Asn Lys Asp Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His 
                965                 970                 975     
Thr Leu Tyr Trp Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr 
            980                 985                 990         
Ser Ile Lys Leu Asn Gly Gln Ala  Glu Leu Phe Tyr Arg  Pro Lys Ser 
        995                 1000                 1005             
Arg Met  Lys Arg Met Ala His  Arg Leu Gly Glu Lys  Met Leu Asn Lys 
    1010                 1015                 1020                 
Lys  Leu Lys Asp Gln Lys  Thr Pro Ile Pro Asp  Thr Leu Tyr Gln Glu  
1025                 1030                 1035                 1040 
Leu Tyr Asp Tyr Val  Asn His Arg Leu Ser  His Asp Leu Ser Asp  Glu 
                1045                 1050                 1055     
Ala Arg Ala Leu  Leu Pro Asn Val Ile  Thr Lys Glu Val Ser  His Glu 
            1060                 1065                 1070         
Ile Ile Lys  Asp Arg Arg Phe Thr  Ser Asp Lys Phe Phe  Phe His Val 
        1075                 1080                 1085             
Pro Ile  Thr Leu Asn Tyr Gln  Ala Ala Asn Ser Pro  Ser Lys Phe Asn 
    1090                 1095                 1100                 
Gln  Arg Val Asn Ala Tyr  Leu Lys Glu His Pro  Glu Thr Pro Ile Ile  
1105                 1110                 1115                 1120 
Gly Ile Ala Arg Gly  Glu Arg Asn Leu Ile  Tyr Ile Thr Val Ile  Asp 
                1125                 1130                 1135     
Ser Thr Gly Lys  Ile Leu Glu Gln Arg  Ser Leu Asn Thr Ile  Gln Gln 
            1140                 1145                 1150         
Phe Asp Tyr  Gln Lys Lys Leu Asp  Asn Arg Glu Lys Glu  Arg Val Ala 
        1155                 1160                 1165             
Ala Arg  Gln Ala Trp Ser Val  Val Gly Thr Ile Lys  Asp Leu Lys Gln 
    1170                 1175                 1180                 
Gly  Tyr Leu Ser Gln Val  Ile His Glu Ile Val  Asp Leu Met Ile His  
1185                 1190                 1195                 1200 
Tyr Gln Ala Val Val  Val Leu Glu Asn Leu  Asn Phe Gly Phe Lys  Ser 
                1205                 1210                 1215     
Lys Arg Thr Gly  Ile Ala Glu Lys Ala  Val Tyr Gln Gln Phe  Glu Lys 
            1220                 1225                 1230         
Met Leu Ile  Asp Lys Leu Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala 
        1235                 1240                 1245             
Glu Lys  Val Gly Gly Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe 
    1250                 1255                 1260                 
Thr  Ser Phe Ala Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  
1265                 1270                 1275                 1280 
Pro Ala Pro Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp 
                1285                 1290                 1295     
Pro Phe Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe 
            1300                 1305                 1310         
Leu Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
        1315                 1320                 1325             
Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly Leu 
    1330                 1335                 1340                 
Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn Glu Thr  
1345                 1350                 1355                 1360 
Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys Arg Ile  Val 
                1365                 1370                 1375     
Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr Arg Asp  Leu Tyr 
            1380                 1385                 1390         
Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu Lys Gly  Ile Val Phe 
        1395                 1400                 1405             
Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu Leu Glu  Asn Asp Asp Ser 
    1410                 1415                 1420                 
His  Ala Ile Asp Thr Met  Val Ala Leu Ile Arg  Ser Val Leu Gln Met  
1425                 1430                 1435                 1440 
Arg Asn Ser Asn Ala  Ala Thr Gly Glu Asp  Tyr Ile Asn Ser Pro  Val 
                1445                 1450                 1455     
Arg Asp Leu Asn  Gly Val Cys Phe Asp  Ser Arg Phe Gln Asn  Pro Glu 
            1460                 1465                 1470         
Trp Pro Met  Asp Ala Asp Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys 
        1475                 1480                 1485             
Gly Gln  Leu Leu Leu Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu 
    1490                 1495                 1500                 
Gln  Asn Gly Ile Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  
1505                 1510                 1515                 1520 
Arg Asn His Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Gly Gly  Ser 
                1525                 1530                 1535     
Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly Lys Gln  Leu Val 
            1540                 1545                 1550         
Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu Val Glu  Glu Val Ile 
        1555                 1560                 1565             
Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu 
    1570                 1575                 1580                 
Ser  Thr Asp Glu Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  
1585                 1590                 1595                 1600 
Lys Pro Trp Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile 
                1605                 1610                 1615     
Lys Met Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  Leu Glu 
            1620                 1625                 1630         
His His His  His His His 
        1635             

<210>  7
<211>  4917
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
atggaagcaa gtccagcctc gggccctcgt cacttaatgg atccgcatat cttcacgtcc        60
aacttcaaca atggcatcgg ccgtcacaag acctatcttt gctatgaagt cgaacgtctg       120
gataacggca cgagcgtaaa gatggatcaa caccgtggtt tccttcacca acaggctaag       180
aacttattat gtgggttcta cggtcgtcac gcagagttgc gcttccttga cctggtacct       240
tcccttcaac tggatcctgc acaaatctac cgcgttacct ggttcatttc ttggagtcca       300
tgcttttctt ggggctgtgc tggcgaagta cgtgcatttt tgcaagagaa tacgcatgtt       360
cgtttgcgta tcttcgcggc ccgcatttat gattatgacc cgctttataa ggaggcttta       420
cagatgttac gtgacgctgg cgcacaggtt tcaattatga cctacgacga gttcaaacac       480
tgctgggaca cattcgtcga tcatcaaggt tgtccctttc aaccctggga tgggttagac       540
gaacacagcc aggcgttgtc gggacgcctg cgtgcgattc ttcaaaatca aggtaacagc       600
gggtccgaga cacccggaac atcggaaagt gccactcctg agtctatgac acagttcgag       660
ggctttacca acctgtatca ggtgagcaag acactgcggt ttgagctgat cccacagggc       720
aagaccctga agcacatcca ggagcagggc ttcatcgagg aggacaaggc ccgcaatgat       780
cactacaagg agctgaagcc catcatcgat cggatctaca agacctatgc cgaccagtgc       840
ctgcagctgg tgcagctgga ttgggagaac ctgagcgccg ccatcgactc ctatagaaag       900
gagaaaaccg aggagacaag gaacgccctg atcgaggagc aggccacata tcgcaatgcc       960
atccacgact acttcatcgg ccggacagac aacctgaccg atgccatcaa taagagacac      1020
gccgagatct acaagggcct gttcaaggcc gagctgttta atggcaaggt gctgaagcag      1080
ctgggcaccg tgaccacaac cgagcacgag aacgccctgc tgcggagctt cgacaagttt      1140
acaacctact tctccggctt ttatcgcaac aggaagaacg tgttcagcgc cgaggatatc      1200
agcacagcca tcccacaccg catcgtgcag gacaacttcc ccaagtttaa ggagaattgt      1260
cacatcttca cacgcctgat caccgccgtg cccagcctgc gggagcactt tgagaacgtg      1320
aagaaggcca tcggcatctt cgtgagcacc tccatcgagg aggtgttttc cttccctttt      1380
tataaccagc tgctgacaca gacccagatc gacctgtata accagctgct gggaggaatc      1440
tctcgggagg caggcaccga gaagatcaag ggcctgaacg aggtgctgaa tctggccatc      1500
cagaagaatg atgagacagc ccacatcatc gcctccctgc cacacagatt catccccctg      1560
tttaagcaga tcctgtccga taggaacacc ctgtctttca tcctggagga gtttaagagc      1620
gacgaggaag tgatccagtc cttctgcaag tacaagacac tgctgagaaa cgagaacgtg      1680
ctggagacag ccgaggccct gtttaacgag ctgaacagca tcgacctgac acacatcttc      1740
atcagccaca agaagctgga gacaatcagc agcgccctgt gcgaccactg ggatacactg      1800
aggaatgccc tgtatgagcg gagaatctcc gagctgacag gcaagatcac caagtctgcc      1860
aaggagaagg tgcagcgcag cctgaagcac gaggatatca acctgcagga gatcatctct      1920
gccgcaggca aggagctgag cgaggccttc aagcagaaaa ccagcgagat cctgtcccac      1980
gcacacgccg ccctggatca gccactgcct acaaccctga agaagcagga ggagaaggag      2040
atcctgaagt ctcagctgga cagcctgctg ggcctgtacc acctgctgga ctggtttgcc      2100
gtggatgagt ccaacgaggt ggaccccgag ttctctgccc ggctgaccgg catcaagctg      2160
gagatggagc cttctctgag cttctacaac aaggccagaa attatgccac caagaagccc      2220
tactccgtgg agaagttcaa gctgaacttt cagatgccta cactggcccg tggctgggac      2280
gtgaatcgcg agaagaacaa tggcgccatc ctgtttgtga agaacggcct gtactatctg      2340
ggcatcatgc caaagcagaa gggcaggtat aaggccctga gcttcgagcc cacagagaaa      2400
accagcgagg gctttgataa gatgtactat gactacttcc ctgatgccgc caagatgatc      2460
ccaaagtgca gcacccagct gaaggccgtg acagcccact ttcagaccca cacaaccccc      2520
atcctgctgt ccaacaattt catcgagcct ctggagatca caaaggagat ctacgacctg      2580
aacaatcctg agaaggagcc aaagaagttt cagacagcct acgccaagaa aaccggcgac      2640
cagaagggct acagagaggc cctgtgcaag tggatcgact tcacaaggga ttttctgtcc      2700
aagtatacca agacaacctc tatcgatctg tctagcctgc ggccatcctc tcagtataag      2760
gacctgggcg agtactatgc cgagctgaat cccctgctgt accacatcag cttccagaga      2820
atcgccgaga aggagatcat ggatgccgtg gagacaggca agctgtacct gttccagatc      2880
tataacaagg actttgccaa gggccaccac ggcaagccta atctgcacac actgtattgg      2940
accggcctgt tttctccaga gaacctggcc aagacaagca tcaagctgaa tggccaggcc      3000
gagctgttct accgccctaa gtccaggatg aagaggatgg cacaccggct gggagagaag      3060
atgctgaaca agaagctgaa ggatcagaaa accccaatcc ccgacaccct gtaccaggag      3120
ctgtacgact atgtgaatca cagactgtcc cacgacctgt ctgatgaggc cagggccctg      3180
ctgcccaacg tgatcaccaa ggaggtgtct cacgagatca tcaaggatag gcgctttacc      3240
agcgacaagt tctttttcca cgtgcctatc acactgaact atcaggccgc caattcccca      3300
tctaagttca accagagggt gaatgcctac ctgaaggagc accccgagac acctatcatc      3360
ggcatcgcgc ggggcgagag aaacctgatc tatatcacag tgatcgactc caccggcaag      3420
atcctggagc agcggagcct gaacaccatc cagcagtttg attaccagaa gaagctggac      3480
aacagggaga aggagagggt ggcagcaagg caggcctggt ctgtggtggg cacaatcaag      3540
gatctgaagc agggctatct gagccaggtc atccacgaga tcgtggacct gatgatccac      3600
taccaggccg tggtggtgct ggagaacctg aatttcggct ttaagagcaa gaggaccggc      3660
atcgccgaga aggccgtgta ccagcagttc gagaagatgc tgatcgataa gctgaattgc      3720
ctggtgctga aggactatcc agcagagaaa gtgggaggcg tgctgaaccc ataccagctg      3780
acagaccagt tcacctcctt tgccaagatg ggcacccagt ctggcttcct gttttacgtg      3840
cctgccccat atacatctaa gatcgatccc ctgaccggct tcgtggaccc cttcgtgtgg      3900
aaaaccatca agaatcacga gagccgcaag cacttcctgg agggcttcga ctttctgcac      3960
tacgacgtga aaaccggcga cttcatcctg cactttaaga tgaacagaaa tctgtccttc      4020
cagaggggcc tgcccggctt tatgcctgca tgggatatcg tgttcgagaa gaacgagaca      4080
cagtttgacg ccaagggcac ccctttcatc gccggcaaga gaatcgtgcc agtgatcgag      4140
aatcacagat tcaccggcag ataccgggac ctgtatcctg ccaacgagct gatcgccctg      4200
ctggaggaga agggcatcgt gttcagggat ggctccaaca tcctgccaaa gctgctggag      4260
aatgacgatt ctcacgccat cgacaccatg gtggccctga tccgcagcgt gctgcagatg      4320
cggaactcca atgccgccac aggcgaggac tatatcaaca gccccgtgcg cgatctgaat      4380
ggcgtgtgct tcgactcccg gtttcagaac ccagagtggc ccatggacgc cgatgccaat      4440
ggcgcctacc acatcgccct gaagggccag ctgctgctga atcacctgaa ggagagcaag      4500
gatctgaagc tgcagaacgg catctccaat caggactggc tggcctacat ccaggagctg      4560
cgcaaccatg gatcacccaa gaagaaacgg aaagtgtctg gtggttctac taatctgtca      4620
gatattattg aaaaggagac cggtaagcaa ctggttatcc aggaatccat cctcatgctc      4680
ccagaggagg tggaagaagt cattgggaac aagccggaaa gcgatatact cgtgcacacc      4740
gcctacgacg agagcaccga cgagaatgtc atgcttctga ctagcgacgc ccctgaatac      4800
aagccttggg ctctggtcat acaggatagc aacggtgaga acaagattaa gatgctctct      4860
ggtggttctc ccaagaagaa gaggaaagtc ctcgagcacc accaccacca ccactga         4917

