                         SEQUENCE LISTING

<110>  IBI-Ag Innovative Bio Insecticides Ltd.
       OREN-BENAROYA, Rony
       AYALI, Amir
       MONSERRATE, Jessica
       VAN RIE, Jeroen
 
<120>  INSECT CONTROL NANOBODIES AND USES THEREOF

<130>  83672

<150>  US 62/933,533
<151>  2019-11-11

<160>  596   

<170>  PatentIn version 3.5

<210>  1
<211>  526
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A polypeptide comprising Chitin binding domain CBD - HaPMP5B1

<400>  1

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Asp Arg Gly Ile Ser Glu Pro Gly Asn Asp 
            20                  25                  30          


Gln Gly Asn Asp Asn Asp Ser Asn Asp Asn Asn Ser Ser Asn Glu Gln 
        35                  40                  45              


Gly Gly Val Cys Asn Cys Asn Pro Glu Glu Ala Pro Ala Ile Cys Ala 
    50                  55                  60                  


Ser Pro Gly Ser Glu Gly Val Leu Val Ala His Glu Asn Cys Glu Lys 
65                  70                  75                  80  


Tyr Tyr Ile Cys Asn His Gly Arg Pro Val Val Ala Ser Cys Ser Gly 
                85                  90                  95      


Asn Leu Leu Phe Asn Pro Tyr Thr Asn Glu Cys Gly Trp Pro Arg Asp 
            100                 105                 110         


Val Asp Cys Gly Asp Arg Ile Glu Pro Gly Cys Thr Gly Cys Asn Asp 
        115                 120                 125             


Asn Asn Asn Asn Asp Asp Asp Asp Ser Asp Cys Asp Gly Asp Asp Pro 
    130                 135                 140                 


Val Pro Pro Pro Ala Asp Asn Asp Asp Ser Glu Ser Ala Asp Ile Asp 
145                 150                 155                 160 


Asp Leu Pro Pro Pro Gly Asp Asp Ala Ser Val Arg Pro Pro Val Asp 
                165                 170                 175     


Glu Gly Thr Cys Asn Cys Asn Pro Glu Gln Ala Pro Ser Ile Cys Ala 
            180                 185                 190         


Glu Asp Asp Ser Asp Gly Val Leu Val Ala His Glu Asp Cys Asn Lys 
        195                 200                 205             


Phe Tyr Lys Cys His Asn Gly Lys Pro Val Ala Leu Tyr Cys Pro Gly 
    210                 215                 220                 


Asn Leu Leu Tyr Asn Pro Asn Thr Glu Gln Cys Asp Trp Pro Glu Lys 
225                 230                 235                 240 


Val Asp Cys Gly Asp Arg Val Ile Pro Asp Pro Glu Asp Asn Thr Val 
                245                 250                 255     


Gly Gly Asn Asn Asp Gly Glu Asp Asp Ser Glu Gly Val Leu Val Ala 
            260                 265                 270         


His Glu Asn Cys Asn Gln Phe Tyr Lys Cys Ser Gly Gly Lys Pro Val 
        275                 280                 285             


Ala Leu Leu Cys Pro Gly Asn Leu Leu Phe Asn Pro Asn Thr Asp Gln 
    290                 295                 300                 


Cys Asp Trp Pro Trp Glu Val Asp Cys Gly Asp Arg Ile Ile Pro Asp 
305                 310                 315                 320 


Pro Asp Arg Thr His Cys Gly Ser His Cys Ser Thr His Cys Ser Thr 
                325                 330                 335     


His Cys Gly Ser Leu Leu Arg Leu Pro Leu Arg Leu His Cys Gly Ser 
            340                 345                 350         


His Cys Gly Ser His Cys Cys Thr Asn Thr Ala Thr Asn Arg Arg Arg 
        355                 360                 365             


Asn Met Gln Leu Gln Ser Trp Ser Thr Phe His Leu Cys Ser Arg Arg 
    370                 375                 380                 


Leu Leu Ile Ala His Glu Asp Cys Asn Lys Phe Tyr Ile Cys Asp His 
385                 390                 395                 400 


Gly Lys Pro Val Ala Leu Ser Cys Pro Gly Asn Leu Leu Tyr Asn Pro 
                405                 410                 415     


Tyr Thr Glu Lys Cys Asp Trp Pro Glu Asn Val Glu Cys Gly Asp Arg 
            420                 425                 430         


Ala Pro Asp Pro Asp Ala Ser Gln Ala Pro Ala Ile Cys Ala Asp Ser 
        435                 440                 445             


Gly Ser Glu Gly Val Leu Val Ala His Glu Asn Cys Asp Gln Tyr Tyr 
    450                 455                 460                 


Ile Cys Asp Gly Gly Arg Pro Val Ala Arg Pro Cys Gln Gly Gly Leu 
465                 470                 475                 480 


Leu Tyr Asn Pro Leu Thr Gln Tyr Cys Asp Gly Gln Glu Met Ser Thr 
                485                 490                 495     


Ala Val Thr Gly Leu Ser Leu Met Thr Ala Pro Val Ile Pro Glu Met 
            500                 505                 510         


Arg Pro Asp Cys Ala Val Ser Gln Thr Pro Lys Glu Ala Trp 
        515                 520                 525     


<210>  2
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A polypeptide comprising Chitin binding domain CBD - HaPMP5B1

<400>  2

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Asp Arg Val Ile Pro Asp Pro Glu Asp Asn Thr 
            20                  25                  30          


Val Gly Gly Asn Asn Asp Gly Glu Asp Asp Ser Glu Gly Val Leu Val 
        35                  40                  45              


Ala His Glu Asn Cys Asn Gln Phe Tyr Lys Cys Ser Gly Gly Lys Pro 
    50                  55                  60                  


Val Ala Leu Leu Cys Pro Gly Asn Leu Leu Phe Asn Pro Asn Thr Asp 
65                  70                  75                  80  


Gln Cys Asp Trp Pro Trp Glu Val Asp Cys Gly Asp Arg Ile Ile Pro 
                85                  90                  95      


Asp Pro Asp Arg Thr His Cys Gly Ser His Cys Ser Thr His Cys Ser 
            100                 105                 110         


Thr His Cys Gly Ser Leu Leu Arg Leu Pro Leu Arg Leu His Cys Gly 
        115                 120                 125             


Ser His Cys Gly Ser His Cys Cys Thr Asn Thr Ala Thr Asn Arg Arg 
    130                 135                 140                 


Arg Asn Met Gln Leu Gln Ser Trp Ser Thr Phe His Leu Cys Ser Arg 
145                 150                 155                 160 


Arg Leu Leu Ile Ala His Glu Asp Cys Asn Lys Phe Tyr Ile Cys Asp 
                165                 170                 175     


His Gly Lys Pro Val Ala Leu Ser Cys Pro Gly Asn Leu Leu Tyr Asn 
            180                 185                 190         


Pro Tyr Thr Glu Lys Cys Asp Trp Pro Glu Asn Val Glu Cys Gly Asp 
        195                 200                 205             


Arg Ala Pro Asp Pro Asp Ala Ser Gln Ala Pro Ala 
    210                 215                 220 


<210>  3
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin binding domain (CBD)

<400>  3

Ser Glu Gly Val Leu Val Ala His Glu Asn Cys Glu Lys Tyr Tyr Ile 
1               5                   10                  15      


Cys Asn His Gly Arg Pro Val Val Ala Ser Cys Ser Gly Asn Leu Leu 
            20                  25                  30          


Phe Asn Pro Tyr Thr Asn Glu Cys Gly Trp Pro Arg Asp 
        35                  40                  45  


<210>  4
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin binding domain (CBD)

<400>  4

Cys Asn Lys Phe Tyr Lys Cys His Asn Gly Lys Pro Val Ala Leu Tyr 
1               5                   10                  15      


Cys Pro Gly Asn Leu Leu Tyr Asn Pro Asn Thr Glu Gln Cys Asp Trp 
            20                  25                  30          


Pro 
    


<210>  5
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin binding domain (CBD)

<400>  5

Ser Glu Gly Val Leu Val Ala His Glu Asn Cys Asn Gln Phe Tyr Lys 
1               5                   10                  15      


Cys Ser Gly Gly Lys Pro Val Ala Leu Leu Cys Pro Gly Asn Leu Leu 
            20                  25                  30          


Phe Asn Pro Asn Thr Asp Gln Cys Asp Trp Pro Trp Glu 
        35                  40                  45  


<210>  6
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin binding domain (CBD)

<400>  6

Glu Asp Cys Asn Lys Phe Tyr Ile Cys Asp His Gly Lys Pro Val Ala 
1               5                   10                  15      


Leu Ser Cys Pro Gly Asn Leu Leu Tyr Asn Pro Tyr Thr Glu Lys Cys 
            20                  25                  30          


Asp Trp Pro Glu Asn 
        35          


<210>  7
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin binding domain (CBD)

<400>  7

Ser Glu Gly Val Leu Val Ala His Glu Asn Cys Asp Gln Tyr Tyr Ile 
1               5                   10                  15      


Cys Asp Gly Gly Arg Pro Val Ala Arg Pro Cys Gln Gly Gly Leu Leu 
            20                  25                  30          


Tyr Asn Pro Leu Thr Gln Tyr Cys Asp 
        35                  40      


<210>  8
<211>  400
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V-ATPase sub unit c

<400>  8

Met His His His His His His Met Ser Glu Tyr Trp Val Ile Ser Ala 
1               5                   10                  15      


Pro Gly Asp Lys Thr Cys Gln Gln Thr Trp Asp Thr Leu Asn Asn Ala 
            20                  25                  30          


Thr Lys Ser Gly Asn Leu Ser Ala Asn Tyr Lys Phe Pro Ile Pro Asp 
        35                  40                  45              


Leu Lys Val Gly Thr Leu Asp Gln Leu Val Gly Leu Ser Asp Asp Leu 
    50                  55                  60                  


Gly Lys Leu Asp Thr Phe Val Glu Ser Val Thr Arg Lys Val Ala Gln 
65                  70                  75                  80  


Tyr Leu Gly Glu Val Leu Glu Asp Gln Arg Asp Lys Leu His Glu Asn 
                85                  90                  95      


Leu Met Ala Asn Asn Ser Asp Met Pro Ser Tyr Leu Thr Arg Phe Gln 
            100                 105                 110         


Trp Asp Met Ala Lys Tyr Pro Ile Lys Gln Ser Leu Arg Asn Ile Ala 
        115                 120                 125             


Asp Ile Ile Ser Lys Gln Val Gly Gln Ile Asp Ser Asp Leu Lys Gln 
    130                 135                 140                 


Lys Ser Ala Ala Tyr Asn Ala Leu Lys Gly Asn Leu Gln Asn Leu Glu 
145                 150                 155                 160 


Lys Lys Gln Thr Gly Ser Leu Leu Thr Arg Asn Leu Ala Asp Leu Val 
                165                 170                 175     


Lys Arg Glu His Phe Ile Leu Asp Ser Glu Tyr Leu Thr Thr Leu Leu 
            180                 185                 190         


Val Ile Val Pro Lys Ser Met Phe Asn Asp Trp Thr Ala Asn Tyr Glu 
        195                 200                 205             


Lys Ile Thr Asp Met Ile Val Pro Arg Ser Ser Gln Leu Ile His Gln 
    210                 215                 220                 


Asp Asn Asp Tyr Gly Leu Phe Asn Val Thr Leu Phe Lys Lys Val Val 
225                 230                 235                 240 


Glu Glu Phe Lys His His Ala Arg Glu Arg Lys Phe Val Val Arg Glu 
                245                 250                 255     


Phe Ser Tyr Asn Glu Ala Asp Met Ala Ala Ala Arg Thr Arg Ser Pro 
            260                 265                 270         


Ser Ser Ser Pro Thr Arg Arg Ser Ser Ser Ile Leu Arg Lys Phe Ile 
        275                 280                 285             


Asn Phe Leu Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser Glu 
    290                 295                 300                 


Cys Phe Cys Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val Glu 
305                 310                 315                 320 


Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Val Val Met 
                325                 330                 335     


Val Pro Ser Arg Lys Asn Thr Lys Lys Leu Arg Glu Val Leu Gln Thr 
            340                 345                 350         


Leu Tyr Ala His Leu Asp His Ser Ala His Gln His Thr Ser Ser Ala 
        355                 360                 365             


Gln Asp Asn Ala Glu Leu Ala Gly Leu Gly Phe Gly Ser Ser Glu Tyr 
    370                 375                 380                 


Phe Pro Tyr Val Phe Tyr Lys Ile Asn Val Asp Met Leu Asp Lys Asn 
385                 390                 395                 400 


<210>  9
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin deacetylase

<400>  9

Met Glu Thr Arg Val Lys Arg Gln Glu Glu Asp Gly Gly Asp Glu Val 
1               5                   10                  15      


Asn Ala Glu Gln Leu Cys Asp Gly Arg Pro Ala Asp Glu Tyr Phe Arg 
            20                  25                  30          


Leu Thr Thr Glu Gly Asp Cys Arg Asp Val Val Arg Cys Thr Arg Ser 
        35                  40                  45              


Gly Leu Lys Gln Ile Thr Cys Pro Ser Gly Leu Ala Phe Asp Leu Asp 
    50                  55                  60                  


Lys Gln Thr Cys Asp Trp Lys Gly Lys Val Thr Asn Cys Asp Lys Leu 
65                  70                  75                  80  


Glu Lys Pro Arg Lys Val Leu Pro Ile Leu Lys Thr Asp Glu Pro Ile 
                85                  90                  95      


Cys Pro Glu Gly Lys Leu Ala Cys Gly Ser Gly Asp Cys Ile Glu Lys 
            100                 105                 110         


Glu Leu Phe Cys Asn Gly Lys Pro Asp Cys Lys Asp Glu Ser Asp Glu 
        115                 120                 125             


Asn Ala Cys Thr Val Asp Val Asp Pro Asn Arg Ala Pro Asp Cys Asp 
    130                 135                 140                 


Pro Asn Gln Cys Ala Leu Pro Asp Cys Phe Cys Ser Ala Asp Gly Thr 
145                 150                 155                 160 


Arg Ile Pro Gly Gly Ile Glu Val Asn Gln Val Pro Gln Met Ile Thr 
                165                 170                 175     


Ile Thr Phe Asn Gly Ala Val Asn Val Asp Asn Ile Asp Leu Tyr Glu 
            180                 185                 190         


Gln Ile Phe Asn Gly Asn Arg His Asn Pro Asn Gly Cys Gln Ile Arg 
        195                 200                 205             


Gly Thr Phe Phe Val Ser His Lys Tyr Thr Asn Tyr Ala Ala Val Gln 
    210                 215                 220                 


Glu Leu His Arg Lys Gly His Glu Ile Ser Val Phe Ser Ile Thr His 
225                 230                 235                 240 


Lys Asp Asp Pro Gln Tyr Trp Ser Ser Gly Ser Tyr Asp Asp Trp Leu 
                245                 250                 255     


Ala Glu Met Ala Gly Ala Arg Leu Ile Val Glu Arg Phe Ala Asn Ile 
            260                 265                 270         


Thr Asp Ser Ser Ile Ile Gly Val Arg Ala Pro Tyr Leu Arg Val Gly 
        275                 280                 285             


Gly Asn Lys Gln Phe Glu Met Met Ala Asp Gln Tyr Phe Val Tyr Asp 
    290                 295                 300                 


Ala Ser Ile Thr Ala Pro Leu Gly Arg Val Pro Ile Trp Pro Tyr Thr 
305                 310                 315                 320 


Leu Tyr Phe Arg Met Pro His Lys Cys Asn Gly Asn Ala His Asn Cys 
                325                 330                 335     


Pro Ser Arg Ser His Pro Val Trp Glu Met Val Met Asn Glu Leu Asp 
            340                 345                 350         


Arg Arg Asp Asp Pro Thr Phe Asp Glu Ser Leu Pro Gly Cys His Val 
        355                 360                 365             


Val Asp Ser Cys Ser Asn Ile Gln Thr Gly Glu Gln Phe Ala Arg Leu 
    370                 375                 380                 


Leu Arg His Asn Ser Asn Arg His Tyr Ser Thr Asn Arg Ala Pro Leu 
385                 390                 395                 400 


Gly Phe His Phe His Ala Ser Trp Leu Lys Ser Lys Lys Glu Phe Arg 
                405                 410                 415     


Asp Glu Leu Ile Lys Phe Ile Glu Glu Met Leu Glu Lys Asn Asp Val 
            420                 425                 430         


Tyr Phe Thr Ser Leu Ile Gln Val Ile Gln Trp Met Gln Asn Pro Thr 
        435                 440                 445             


Glu Leu Thr Ser Leu Arg Asp Phe Gln Glu Trp Lys Gln Asp Lys Cys 
    450                 455                 460                 


Asp Val Lys Gly Gln Pro Phe Cys Ser Leu Pro Asn Ala Cys Pro Leu 
465                 470                 475                 480 


Thr Thr Arg Glu Leu Pro Gly Glu Thr Leu Arg Leu Phe Thr Cys Met 
                485                 490                 495     


Glu Cys Pro Asn Asn Tyr Pro Trp Ile Leu Asp Pro Thr Gly Glu Gly 
            500                 505                 510         


Phe Asn Val Lys 
        515     


<210>  10
<211>  548
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Trehalase

<400>  10

Met Asp Leu Pro Leu Thr Cys Thr Lys Pro Val Tyr Cys Asn Ser Asn 
1               5                   10                  15      


Leu Leu His Gln Ile Gln Met Ala Arg Leu Tyr Asn Asp Ser Lys Thr 
            20                  25                  30          


Phe Val Asp Leu Gln Met Asn Phe Asp Glu Asn Lys Thr Leu Thr Asp 
        35                  40                  45              


Phe Glu Thr Phe Phe Asn Leu His Asn Lys Asn Pro Thr Lys Glu Gln 
    50                  55                  60                  


Leu Met Glu Phe Val Asn Glu Tyr Phe Ser Asn Asp Asn Glu Leu Glu 
65                  70                  75                  80  


Pro Trp Gln Pro Lys Asp Phe Ser Asp Asn Pro Ala Phe Leu Ala Lys 
                85                  90                  95      


Ile Lys Asp Asp Ala Leu Arg Glu Phe Gly Lys Gly Ile Asn Asn Ile 
            100                 105                 110         


Trp Pro Leu Leu Ala Arg Lys Val Lys Ala Glu Val Phe Gln Lys Pro 
        115                 120                 125             


Asp Gln Phe Ser Leu Val Pro Leu Thr His Gly Phe Ile Ile Pro Gly 
    130                 135                 140                 


Gly Arg Phe Lys Glu Ile Tyr Tyr Trp Asp Thr Phe Trp Ile Ile Glu 
145                 150                 155                 160 


Gly Leu Leu Ile Ser Gly Met Gln Glu Thr Ala Lys Gly Met Ile Glu 
                165                 170                 175     


Asn Leu Ile Glu Leu Leu Asn Leu Phe Gly His Ile Pro Asn Gly Ser 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Gln Arg Ser Gln Pro Pro Met Leu Asn Ala Met 
        195                 200                 205             


Val Ala Thr Tyr Tyr Met Tyr Thr Lys Asp Leu Glu Phe Leu Arg Asn 
    210                 215                 220                 


Asn Ile Ala Tyr Leu Glu Lys Glu Leu Asp Phe Trp Met Asp Asn Arg 
225                 230                 235                 240 


Val Val Ser Val Asn Arg Gly Gly Lys Asn Tyr Thr Leu Leu Arg Tyr 
                245                 250                 255     


Tyr Ala Pro Ser Lys Gly Pro Arg Pro Glu Ser Tyr Tyr Glu Asp Tyr 
            260                 265                 270         


Ser Asn Thr Glu Gly Phe Ser Glu Glu Asp Ser Thr Asn Phe Cys Ile 
        275                 280                 285             


Asp Ile Lys Ser Ala Ala Glu Ser Gly Trp Asp Phe Ser Thr Arg Trp 
    290                 295                 300                 


Phe Leu Met Pro Asp Gly Ser Asn Asn Gly Thr Leu Thr Asp Leu His 
305                 310                 315                 320 


Thr Arg Tyr Ile Ile Pro Val Asp Leu Asn Ala Ile Phe Ala Gly Ala 
                325                 330                 335     


Ala Gln Tyr Val Ser Asn Phe His Ala Leu Leu Lys Asn Pro Gln Lys 
            340                 345                 350         


Ala Ala Arg Tyr Gly Gln Leu Ala Gln Thr Trp Arg Asp Asn Ile Gln 
        355                 360                 365             


Ala Val Leu Trp Asn Asp Gln Asp Ala Met Trp Tyr Asp Phe Asn Ile 
    370                 375                 380                 


Arg Asp Asn Leu His Arg Arg Tyr Tyr Tyr Ser Ser Asn Ala Ala Pro 
385                 390                 395                 400 


Leu Trp Gln Asn Ala Val Asn Pro Asp Phe Leu Lys Leu Asn Ala Asp 
                405                 410                 415     


Arg Ile Leu Lys Ala Ile Thr Glu Ser Gly Gly Val Asp Phe Pro Gly 
            420                 425                 430         


Gly Val Pro Thr Ser Leu Ile Arg Ser Gly Glu Gln Trp Asp Phe Pro 
        435                 440                 445             


Asn Val Trp Pro Pro Glu Val Ser Ile Glu Val Ala Ala Ile Glu Asn 
    450                 455                 460                 


Ile Gly Thr Pro Glu Ala Ile Thr Leu Ala Gln Glu Val Ala Gln Thr 
465                 470                 475                 480 


Phe Val Arg Ser Cys His Trp Gly Phe Gln Lys Tyr Lys Gln Met Phe 
                485                 490                 495     


Glu Lys Tyr Asp Ala Glu Thr Pro Gly Arg Phe Gly Gly Gly Gly Glu 
            500                 505                 510         


Tyr Asn Val Gln Phe Gly Phe Gly Trp Ser Asn Gly Val Val Leu Glu 
        515                 520                 525             


Phe Leu Asn Lys Tyr Gly Ser Gln Leu Thr Ala Asp Asp Ser Asn Asn 
    530                 535                 540                 


Thr Asn Asn Ser 
545             


<210>  11
<211>  483
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cytochrome p450 monooxygenase

<400>  11

Met Arg Thr Phe Asn Tyr Trp Lys Lys Arg Asn Val Arg Gly Pro Glu 
1               5                   10                  15      


Pro Val Val Phe Phe Gly Asn Leu Lys Asp Ser Ala Leu Arg Lys Lys 
            20                  25                  30          


Asn Met Gly Val Val Met Glu Glu Leu Tyr Asn Met Phe Pro Glu Glu 
        35                  40                  45              


Lys Val Ile Gly Ile Tyr Arg Met Thr Ser Pro Cys Leu Leu Val Arg 
    50                  55                  60                  


Asp Leu Asp Val Ile Lys His Ile Met Ile Lys Asp Phe Glu Val Phe 
65                  70                  75                  80  


Ser Asp Arg Gly Val Glu Phe Ser Lys Glu Gly Leu Gly Ser Asn Leu 
                85                  90                  95      


Phe His Ala Asp Gly Glu Thr Trp Arg Ala Leu Gly Asn Arg Phe Thr 
            100                 105                 110         


Pro Ile Phe Thr Ser Gly Lys Leu Lys Asn Met Phe Tyr Leu Met His 
        115                 120                 125             


Glu Gly Ala Asp Asn Phe Ile Asp His Val Ser Ala Glu Cys Glu Lys 
    130                 135                 140                 


Asn Gln Glu Phe Glu Val His Ser Leu Leu Gln Thr Tyr Thr Met Ser 
145                 150                 155                 160 


Thr Ile Ala Ala Cys Ala Phe Gly Ile Ser Tyr Asp Ser Ile Gly Asp 
                165                 170                 175     


Lys Val Lys Ala Leu Asp Ile Val Asp Lys Ile Ile Ser Glu Pro Ser 
            180                 185                 190         


Tyr Ala Ile Glu Leu Asp Met Met Tyr Pro Gly Leu Leu Ser Lys Leu 
        195                 200                 205             


Asn Leu Ser Ile Phe Pro Thr Val Val Lys Asn Phe Phe Lys Ser Leu 
    210                 215                 220                 


Val Asp Asn Ile Val Ala Gln Arg Asn Gly Lys Pro Ser Gly Arg Asn 
225                 230                 235                 240 


Asp Phe Met Asp Leu Ile Leu Glu Leu Arg Gln Leu Gly Glu Val Thr 
                245                 250                 255     


Ser Asn Lys Tyr Gly Ser Ser Ala Ser Ser Leu Glu Ile Thr Asp Glu 
            260                 265                 270         


Val Ile Cys Ala Gln Ala Phe Val Phe Tyr Ile Ala Gly Tyr Glu Thr 
        275                 280                 285             


Ser Ala Thr Thr Met Ala Tyr Met Ile Tyr Gln Leu Ala Leu Asn Pro 
    290                 295                 300                 


Asp Ile Gln Asn Lys Leu Ile Ala Glu Val Asp Glu Val Leu Lys Ala 
305                 310                 315                 320 


Asn Asp Gly Lys Val Thr Tyr Asp Thr Val Lys Glu Met Lys Tyr Leu 
                325                 330                 335     


Asn Lys Ala Phe Asp Glu Thr Leu Arg Met Tyr Ser Ile Val Glu Pro 
            340                 345                 350         


Leu Gln Arg Lys Ala Thr Arg Asp Tyr Lys Ile Pro Gly Thr Asp Val 
        355                 360                 365             


Val Ile Glu Lys Asp Thr Ile Val Leu Ile Ser Pro Arg Gly Ile His 
    370                 375                 380                 


Tyr Asp Pro Lys Tyr Tyr Asp Asn Pro Lys Gln Phe Asn Pro Asp Arg 
385                 390                 395                 400 


Phe Asp Ala Glu Glu Val Gly Lys Arg His Pro Cys Ala Tyr Leu Pro 
                405                 410                 415     


Phe Gly Leu Gly Gln Arg Asn Cys Ile Gly Met Arg Phe Gly Arg Leu 
            420                 425                 430         


Gln Ser Leu Leu Cys Ile Thr Lys Ile Leu Ser Lys Phe Arg Ile Glu 
        435                 440                 445             


Pro Ser Lys Asn Thr Asp Arg Asn Leu Gln Val Glu Pro His Arg Gly 
    450                 455                 460                 


Leu Ile Gly Pro Lys Gly Gly Ile Arg Val Asn Ala Ile Pro Arg Lys 
465                 470                 475                 480 


Leu Val Ser 
            


<210>  12
<211>  415
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chitin synthase

<400>  12

Asn Cys Tyr Phe His Gly Thr Val Pro Asp Tyr Leu Tyr Phe Glu Ser 
1               5                   10                  15      


Pro Pro Val Phe Thr Leu Ser Asp Phe Ile Ser Arg Gln Met Ala Trp 
            20                  25                  30          


Ile Cys Arg Thr Phe Gly Leu Asn Glu Lys Leu Phe Val Met Pro Met 
        35                  40                  45              


Tyr Asn Gly Leu Leu Ile Asp Gln Ser Met Ala Leu Asn Arg Lys Arg 
    50                  55                  60                  


Asn Asp Gln Arg Asp Val Lys Thr Glu Asp Leu Ala Glu Ile Glu Lys 
65                  70                  75                  80  


Glu Lys Gly Asp Glu Tyr Tyr Glu Thr Ile Ser Val His Thr Asp Asn 
                85                  90                  95      


Thr Gly Ser Ser Pro Lys Ala Ile Lys Ser Ser Asp Gln Ile Thr Arg 
            100                 105                 110         


Ile Tyr Ala Cys Ala Thr Met Trp His Glu Thr Lys Asp Glu Met Met 
        115                 120                 125             


Glu Phe Leu Lys Ser Ile Leu Arg Leu Asp Glu Asp Gln Cys Ala Arg 
    130                 135                 140                 


Arg Val Ala Gln Lys Tyr Leu Arg Val Val Asp Pro Asp Tyr Tyr Glu 
145                 150                 155                 160 


Phe Glu Thr His Ile Phe Leu Asp Asp Ala Phe Glu Ile Ser Asp His 
                165                 170                 175     


Ser Asp Asp Asp Ser Gln Val Asn Arg Phe Val Lys Leu Leu Val Asp 
            180                 185                 190         


Thr Ile Asp Glu Ala Ala Ser Glu Val His Gln Thr Asn Ile Arg Asp 
        195                 200                 205             


Val His Val Leu Pro Ser Arg Ser Ser Phe Asn Gly Thr Ala Asp Ile 
    210                 215                 220                 


Leu Asp Arg Lys Glu Val Met Ala Glu Asn Thr Tyr Leu Leu Thr Leu 
225                 230                 235                 240 


Asp Gly Asp Ile Asp Phe Gln Pro His Ala Val Arg Leu Leu Ile Asp 
                245                 250                 255     


Leu Met Lys Lys Asn Lys Asn Leu Gly Ala Ala Cys Gly Arg Ile His 
            260                 265                 270         


Pro Val Gly Ser Gly Pro Met Val Trp Tyr Gln Met Phe Glu Tyr Ala 
        275                 280                 285             


Ile Gly His Trp Leu Gln Lys Ala Thr Glu His Met Ile Gly Cys Val 
    290                 295                 300                 


Leu Cys Ser Pro Gly Cys Phe Ser Leu Phe Arg Gly Lys Ala Leu Met 
305                 310                 315                 320 


Asp Asp Asn Val Met Lys Lys Tyr Thr Leu Arg Ser Asp Glu Ala Arg 
                325                 330                 335     


His Tyr Val His Thr Ile Arg Gly Arg Ser Met Val Met Tyr Ala Ile 
            340                 345                 350         


Thr Ala Thr Trp Leu Ser Cys Arg Ile Leu Ser Cys Leu Arg Cys Tyr 
        355                 360                 365             


Thr His Cys Pro Glu Gly Phe Asn Glu Phe Tyr Asn Arg Arg Arg Trp 
    370                 375                 380                 


Val Pro Ser Thr Ile Ala Asn Ile Met Asp Leu Leu Ala Asp Cys Lys 
385                 390                 395                 400 


His Thr Ile Lys Ile Asn Asp Asn Ile Ser Ser Pro Tyr Ile Ala 
                405                 410                 415 


<210>  13
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  13 NPC1-sterol transporter

<400>  13

Asp Ser Phe Gln Thr Lys Tyr Phe Gln Tyr Leu Asn Arg Tyr Leu Asn 
1               5                   10                  15      


Ile Gly Pro Pro Val Tyr Phe Val Val Thr Glu Gly Leu Asn Tyr Ser 
            20                  25                  30          


Asp Met Asp Thr Gln Asn Met Ile Cys Gly Thr Arg Phe Cys Arg Pro 
        35                  40                  45              


Asp Ser Leu Ser Met Gln Leu Tyr Ala Ala Tyr Arg Asn Pro Asn Glu 
    50                  55                  60                  


Thr Tyr Ile Ala Gln Pro Pro Asn Ser Trp Leu Asp Asp Tyr Phe Asp 
65                  70                  75                  80  


Trp Ser Ala Leu Pro Asn Cys Cys Lys Tyr Phe Pro Ser Asn Ser Ser 
                85                  90                  95      


Phe Cys Pro Asn Asp Arg Gly Ala Pro Cys Lys Ala Cys Gly Ile Ala 
            100                 105                 110         


Leu Glu Gly Asp Glu Gln Arg Pro Asn Ser Thr Glu Phe Glu Arg Tyr 
        115                 120                 125             


Val Pro Phe Phe Leu Gln Asp Ile Pro Asp Thr Ser Gly Ser Gly Cys 
    130                 135                 140                 


Val Lys Gly Gly His Ala Ala Tyr Gly Gln Ala Val Asn Tyr Lys Met 
145                 150                 155                 160 


Phe Asn Lys Thr Gln Ala His Val Gly Ala Thr Tyr Tyr Gln Gly Tyr 
                165                 170                 175     


His Thr Val Leu Lys Thr Ser Leu Asp Tyr Tyr Ser Ala Leu Lys Gly 
            180                 185                 190         


Ala Arg Glu Val Ala Ala Asn Leu Thr Glu Thr Leu Asn Arg Asn Leu 
        195                 200                 205             


Lys His Gln Leu Asn Gly Thr Thr Ile Asn Val Phe Pro Tyr Ser Val 
    210                 215                 220                 


Phe Tyr Val Phe Tyr Glu Gln Tyr Leu Thr Met Trp Pro Asp Thr Leu 
225                 230                 235                 240 


<210>  14
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  14

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ile 
            20                  25                  30          


Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe 
        35                  40                  45              


Val Thr Ala Ile Ser Pro Ser Gly Gly Ser Thr His Tyr Ala Asp Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Ser Thr Ser Ser Gln His Tyr Glu Asp Thr Glu Glu Ser Tyr 
            100                 105                 110         


Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  15
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  15

Gly Arg Ser Phe Ser Ile Tyr Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  16

Ile Ser Pro Ser Gly Gly Ser Thr 
1               5               


<210>  17
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  17

Ala Ser Thr Ser Ser Gln His Tyr Glu Asp Thr Glu Glu Ser Tyr Lys 
1               5                   10                  15      


Tyr 
    


<210>  18
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  18

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Glu Ala Ala 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Leu Gly Ser Asn Leu Arg Ile 
            20                  25                  30          


Asn Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Thr Ile Thr Asn Gly Gly Arg Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Gly Asn Ala Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Leu Leu Asp Pro Pro Tyr Ser Ala Pro Gly Asp Tyr Trp Gly 
            100                 105                 110         


Glu Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  19
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  19

Leu Gly Ser Asn Leu Arg Ile Asn Thr 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  20

Thr Ile Thr Asn Gly Gly Arg Lys Asn Tyr 
1               5                   10  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  21

Asn Ala Gly Leu Leu Asp Pro Pro Tyr Ser Ala Pro Gly Asp Tyr 
1               5                   10                  15  


<210>  22
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  22

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Thr 
            20                  25                  30          


Tyr Ala Met Gly Trp Ser Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Leu Ala Gly Ile Ser Arg Gly Gly Gly Thr Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ala Leu Arg Pro Phe Asp Gly Ser Gly Glu Arg Arg Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  23

Gly Arg Ser Phe Ser Thr Tyr Ala 
1               5               


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  24

Gly Ile Ser Arg Gly Gly Gly Thr Thr 
1               5                   


<210>  25
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  25

Ala Ala Leu Arg Pro Phe Asp Gly Ser Gly Glu Arg Arg Tyr Asp Tyr 
1               5                   10                  15      


<210>  26
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  26

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ile 
            20                  25                  30          


Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Ile Ser Pro Ser Gly Val Ser Thr Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly Gly Arg His Tyr Thr Arg His Pro Tyr Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  27

<400>  27
000

<210>  28
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  28

Ala Ile Ser Pro Ser Gly Val Ser Thr Asp 
1               5                   10  


<210>  29
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  29

Ala Ala Gly Gly Arg His Tyr Thr Arg His Pro Tyr Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  30
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  30

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser 
            20                  25                  30          


Tyr Ser Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Gly Arg Glu Trp 
        35                  40                  45              


Val Ala Asp Ile Asn Glu Ser Gly Ser Ser Thr Ser Tyr Tyr Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Leu Val Thr Gly Gly Asp Thr Asp Leu Gly Glu Trp Asp 
            100                 105                 110         


Phe Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  31
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  31

Gly Arg Ser Phe Ser Ser Tyr Ser 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  32

Ile Asn Glu Ser Gly Ser Ser Thr 
1               5               


<210>  33
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  33

Ala Ala Leu Val Thr Gly Gly Asp Thr Asp Leu Gly Glu Trp Asp Phe 
1               5                   10                  15      


<210>  34
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  34

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser 
            20                  25                  30          


Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Arg Ile Gly Val Ser Glu Gly Tyr Leu Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly Pro Arg Arg Tyr Trp Thr Arg Glu Pro Asp Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  35

Gly Gly Thr Phe Ser Ser Tyr Val 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  36

Ile Gly Val Ser Glu Gly Tyr Leu 
1               5               


<210>  37
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  37

Ala Ala Gly Pro Arg Arg Tyr Trp Thr Arg Glu Pro Asp Ala Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  38
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  38

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Gly Ala Ser Gly Arg Thr Phe Ser Thr 
            20                  25                  30          


Asn Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Thr Ile Ser Ala Gly Gly Ser Leu Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Arg Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Gln Asp Ser Gly Arg Leu Pro Leu Ile Asn Ser Gly 
            100                 105                 110         


Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  39
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  39

Gly Arg Thr Phe Ser Thr Asn Ala 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  40

Ile Ser Ala Gly Gly Ser Leu Thr 
1               5               


<210>  41
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  41

Ala Ala Asp Gln Asp Ser Gly Arg Leu Pro Leu Ile Asn Ser Gly Tyr 
1               5                   10                  15      


Glu Tyr 
        


<210>  42
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  42

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Ala Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser 
            20                  25                  30          


Tyr Gly Thr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ala Ile Leu Trp Thr Gly Ser Ser Ser Tyr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ile Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Ser Arg Tyr Thr Gly Ser Tyr Tyr Glu Glu Ser Thr 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  43
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  43

Gly Arg Thr Phe Ser Ser Tyr Gly Thr Ala 
1               5                   10  


<210>  44
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  44

Ile Leu Trp Thr Gly Ser Ser Ser 
1               5               


<210>  45
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  45

Ala Ala Arg Ser Arg Tyr Thr Gly Ser Tyr Tyr Glu Glu Ser Thr Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  46
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  46

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asp Phe Ser Asn 
            20                  25                  30          


Tyr Asn Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Val 
        35                  40                  45              


Val Ala Thr Ile Arg Arg Ser Gly Asp Ile Thr Ser Tyr Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Thr Gly Ser Phe Leu Thr Val Leu Ile Thr Thr Pro 
            100                 105                 110         


Gly Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  47
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  47

Gly Arg Asp Phe Ser Asn Tyr Asn 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  48

Ile Arg Arg Ser Gly Asp Ile Thr 
1               5               


<210>  49
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  49

Ala Ala Arg Thr Gly Ser Phe Leu Thr Val Leu Ile Thr Thr Pro Gly 
1               5                   10                  15      


Asn Tyr Asn Tyr 
            20  


<210>  50
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  50

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ala 
            20                  25                  30          


Phe Arg Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ala Leu 
        35                  40                  45              


Val Ala Asp Ile Ser Arg Leu Ser Thr Arg Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Leu Glu Gly Val Gly Pro Met Trp Glu Tyr Trp Val 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  51
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  51

Gly Arg Thr Phe Ser Ala Phe Arg 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  52

Ile Ser Arg Leu Ser Thr Arg Thr 
1               5               


<210>  53
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  53

Ala Ala Asp Leu Glu Gly Val Gly Pro Met Trp Glu Tyr 
1               5                   10              


<210>  54
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  54

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
1               5                   10                  15      


Asn Ser Leu Arg Leu Ser Cys Thr Tyr Ser Gly Arg Thr Phe Ser Thr 
            20                  25                  30          


Arg Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Gly Ile Gly Trp Asn Gly Ala Thr Gln Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Ser Asn Thr Val 
65                  70                  75                  80  


Ala Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala His Gly Arg Glu Tyr Val Thr Pro Ser Tyr Asn Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  55
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  55

Gly Arg Thr Phe Ser Thr Arg Ala 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  56

Ile Gly Trp Asn Gly Ala Thr Gln 
1               5               


<210>  57
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  57

Ala Ala His Gly Arg Glu Tyr Val Thr Pro Ser Tyr Asn Asn Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  58
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  58

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Thr Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Val Arg 
            20                  25                  30          


Tyr Thr Thr Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ser Ile Ser Trp Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Pro Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Asn Ser Arg Gly Ala Thr Thr Phe Ala Gln Tyr Tyr Asp 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  59

Gly Arg Ser Phe Val Arg Tyr Thr 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  60

Ile Ser Trp Ser Arg Gly Ser Thr 
1               5               


<210>  61
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  61

Ala Gly Asn Ser Arg Gly Ala Thr Thr Phe Ala Gln Tyr Tyr Asp Asp 
1               5                   10                  15      


<210>  62
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  62

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Leu 
            20                  25                  30          


Thr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile 
        35                  40                  45              


Val Ala His Ile Met Arg Ser Ser Asp Ser Thr Phe Tyr Gly Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Arg Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ala Gln Trp Ala Gly Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Gly Ser His His His His His His 
    130                 135         


<210>  63
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  63

Gly Arg Thr Phe Ser Leu Thr Arg 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  64

Ile Met Arg Ser Ser Asp Ser Thr 
1               5               


<210>  65
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  65

Ala Ala Ala Gln Trp Ala Gly Tyr Asp Tyr 
1               5                   10  


<210>  66
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  66

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Pro Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Ser 
            20                  25                  30          


Ser Thr Met Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Ile Ser Pro Arg Gly Leu Ser Gln Asp Tyr Gly His Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Thr Ser Gly Ser Tyr Ser Ser Ser Arg Asn Asp Tyr Tyr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  67
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  67

Gly Arg Thr Phe Thr Ser Ser Thr 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  68

Ile Ser Pro Arg Gly Leu Ser Gln 
1               5               


<210>  69
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  69

Ala Ala Thr Ser Gly Ser Tyr Ser Ser Ser Arg Asn Asp Tyr Tyr Tyr 
1               5                   10                  15      


<210>  70
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  70

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn 
            20                  25                  30          


Tyr Arg Met Ala Trp Phe Arg Gln Gly Leu Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala His Ile Met Arg Asn Ser Asp Thr Thr Trp Tyr Thr Glu Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ser Asn Ala Gly Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Gly Ser His His His His His His 
    130                 135         


<210>  71
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  71

Gly Phe Thr Leu Ser Asn Tyr Arg 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  72

Ile Met Arg Asn Ser Asp Thr Thr 
1               5               


<210>  73
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  73

Ala Ala Ser Asn Ala Gly Thr Phe Asp Tyr 
1               5                   10  


<210>  74
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  74

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ala Asn Ile Arg Leu 
            20                  25                  30          


Tyr Gly Met Ala Trp Tyr Arg Gln Pro Pro Gly Glu Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Ser Ile Thr Val Gly Gly Ser Ile Thr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Met Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Met Asn Pro Trp Tyr Tyr Trp Ala Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  75
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  75

Gly Ala Asn Ile Arg Leu Tyr Gly 
1               5               


<210>  76
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  76

Ile Thr Val Gly Gly Ser Ile 
1               5           


<210>  77
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  77

Asn Ala Met Asn Pro Trp Tyr Tyr Trp Ala 
1               5                   10  


<210>  78
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  78

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Leu Ser Ser 
            20                  25                  30          


Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Asp Phe 
        35                  40                  45              


Val Ala Gly Ile Asp Trp Ser Gly Gly Ser Thr Asn Tyr Glu Arg Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Leu Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ala Arg Ala Asn Ser Asp Leu Gly Ile Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  79
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  79

Gly Gly Thr Leu Ser Ser Tyr Asp 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  80

Ile Asp Trp Ser Gly Gly Ser Thr 
1               5               


<210>  81
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  81

Ala Ala Ala Arg Ala Asn Ser Asp Leu Gly Ile Tyr Asp Tyr 
1               5                   10                  


<210>  82
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  82

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Glu Ala Gly 
1               5                   10                  15      


Gly Ser Leu Gly Leu Ala Cys Thr Thr Ser Gly Ile Ile Phe Ser Arg 
            20                  25                  30          


Asn Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Gln Arg Thr Ala 
        35                  40                  45              


Val Ala Thr Ile Thr Arg Ser Ser Ser Thr Asn Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ile Pro Thr Ala Thr Gln Pro Tyr Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  83
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  83

Gly Ile Ile Phe Ser Arg Asn Asp 
1               5               


<210>  84
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  84

Ile Thr Arg Ser Ser Ser Thr 
1               5           


<210>  85
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  85

Ala Thr Ile Pro Thr Ala Thr Gln Pro Tyr Val Tyr 
1               5                   10          


<210>  86
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  86

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser 
            20                  25                  30          


Tyr Ser Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Gly Arg Glu Trp 
        35                  40                  45              


Val Ala Asp Ile Asn Glu Ser Gly Thr Thr Thr Asn Tyr Trp Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gln Asn Met Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly Pro Arg Thr Arg Trp Thr Arg Glu Pro Asp Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  87
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  87

Gly Arg Ser Phe Ser Ser Tyr Ser 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  88

Ile Asn Glu Ser Gly Thr Thr Thr 
1               5               


<210>  89
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  89

Ala Ala Gly Pro Arg Thr Arg Trp Thr Arg Glu Pro Asp Ala Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  90
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  90

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Thr 
            20                  25                  30          


Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe 
        35                  40                  45              


Val Ala Gly Ile Asp Trp Ser Gly Gly Ser Thr Asn Tyr Val Asn Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ala Val Gly Asp Ser Glu Met Ala Thr Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  91
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  91

Gly Arg Thr Phe Ser Thr Tyr Asp 
1               5               


<210>  92

<400>  92
000

<210>  93
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  93

Ala Ala Ala Val Gly Asp Ser Glu Met Ala Thr Tyr Asp Tyr 
1               5                   10                  


<210>  94
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  94

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Pro Thr Phe Arg Pro 
            20                  25                  30          


Asn Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala His Ile Met Trp Ser Ser Gly Ser Thr Trp Tyr Gly Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Ile Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ala Gln Arg Ala Gly Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Gly Ser His His His His His His 
    130                 135         


<210>  95
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  95

Glu Pro Thr Phe Arg Pro Asn Arg 
1               5               


<210>  96
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  96

Ile Met Trp Ser Ser Gly Ser Thr Trp 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  97

Ala Ala Gln Arg Ala Gly Tyr Asp Tyr 
1               5                   


<210>  98
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  98

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Ser 
            20                  25                  30          


Tyr Ser Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe 
        35                  40                  45              


Val Thr Ala Ile Arg Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Ala Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Leu Gly Gly Arg Ser Trp Asp Ala Gly Asp Tyr Gln 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  99
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  99

Gly Arg Ser Leu Ser Ser Tyr Ser 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  100

Ile Arg Trp Ser Gly Gly Ser Thr 
1               5               


<210>  101
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  101

Ala Ala Arg Leu Gly Gly Arg Ser Trp Asp Ala Gly Asp Tyr Gln Tyr 
1               5                   10                  15      


<210>  102
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  102

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ser Gly 
1               5                   10                  15      


Gly Ser Leu Phe Leu Ser Cys Ala Ala Ser Gly Phe Val Phe Glu Thr 
            20                  25                  30          


Ser Pro Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Val Arg Trp 
        35                  40                  45              


Val Gly Ser Ile Thr Thr Asp Gly Arg Arg Ala Asp Tyr Glu Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Met Leu 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Phe 
                85                  90                  95      


Cys Arg Glu Ser Arg Asp Leu Asn Ala Val Thr Arg Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  103
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  103

Gly Phe Val Phe Glu Thr Ser Pro 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  104

Ile Thr Thr Asp Gly Arg Arg Ala 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  105

Arg Glu Ser Arg Asp Leu Asn Ala 
1               5               


<210>  106
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  106

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Gly Ser Ile 
            20                  25                  30          


Asn Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile 
        35                  40                  45              


Val Ser His Ile Phe Trp Ser Asn Val Gly Thr Trp Ser Ala Glu Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser 
                85                  90                  95      


Cys Ala Ala Ala Thr Gly Ser Ala Tyr Asn Tyr Trp Val Pro Ser Arg 
            100                 105                 110         


Gly Asp Pro Gly His Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  107
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  107

Gly Arg Thr Gly Ser Ile Asn Arg 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  108

Ile Phe Trp Ser Asn Val Gly Thr 
1               5               


<210>  109
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  109

Ala Ala Ala Thr Gly Ser Ala Tyr Asn Tyr 
1               5                   10  


<210>  110
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  110

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Gln Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Met Ser Phe Ser Thr 
            20                  25                  30          


Ser Ala Met Gly Trp Tyr Arg Gln Ala Ser Gly Lys Gln Arg Glu Trp 
        35                  40                  45              


Val Ala Ile Ile Arg Glu Asp Ser Thr Thr Asn Tyr Ser Ser Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Asn Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Arg Thr Tyr Thr Gly Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His 
        115                 120                 125             


His His His His His 
    130             


<210>  111
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  111

Gly Met Ser Phe Ser Thr Ser Ala 
1               5               


<210>  112
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  112

Ile Arg Glu Asp Ser Thr Thr 
1               5           


<210>  113
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  113

Arg Thr Tyr Thr Gly Gly Tyr 
1               5           


<210>  114
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  114

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Gly Ile Ser Trp Ser Gly Arg Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Pro Asp Thr Ala Ala Gln Phe Thr Thr Pro Leu Tyr Glu 
            100                 105                 110         


Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  115
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  115

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  116
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  116

Ile Ser Trp Ser Gly Arg Ser Thr 
1               5               


<210>  117
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  117

Ala Ala Pro Asp Thr Ala Ala Gln Phe Thr Thr Pro Leu Tyr Glu Tyr 
1               5                   10                  15      


<210>  118
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  118

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ala Cys Ala Ser Ser Ser Arg Thr Phe Ser Thr 
            20                  25                  30          


Tyr Thr Met Gly Trp Phe Arg Gln Thr Pro Gly Arg Glu Arg Asp Phe 
        35                  40                  45              


Val Ala Ala Ile Ser Pro Ser Gly Ala Thr Ala Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Tyr Leu Ser Trp Ser Arg Met Asn His Glu Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  119
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  119

Ser Arg Thr Phe Ser Thr Tyr Thr 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  120

Ile Ser Pro Ser Gly Ala Thr Ala 
1               5               


<210>  121
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  121

Ala Ala Arg Tyr Leu Ser Trp Ser Arg Met Asn His Glu Tyr Pro Tyr 
1               5                   10                  15      


<210>  122
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  122

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser 
            20                  25                  30          


Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Arg Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Met Thr Trp Ser Gly Ser Ser Arg Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Lys Asp Ala Tyr Gly Gly Ile Ser Phe Arg Pro Asn 
            100                 105                 110         


Thr Tyr His Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His 
    130                 135                 140                 


His His 
145     


<210>  123
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  123

Glu Arg Thr Phe Ser Ser Tyr Val 
1               5               


<210>  124
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  124

Met Thr Trp Ser Gly Ser Ser Arg Ile 
1               5                   


<210>  125
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  125

Ala Ala Lys Asp Ala Tyr Gly Gly Ile Ser Phe Arg Pro Asn Thr Tyr 
1               5                   10                  15      


His Ser 
        


<210>  126
<211>  130
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  126

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Leu Gly Asn Ile Val Asn Ile 
            20                  25                  30          


Asn Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Gly Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Thr Ile Thr Arg Gly Ala Ile Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Gly Asn Ala Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Ala Asp Ser Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His 
        115                 120                 125             


His His 
    130 


<210>  127
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  127

Gly Asn Ile Val Asn Ile Asn Asn 
1               5               


<210>  128
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  128

Ile Thr Arg Gly Ala Ile Lys 
1               5           


<210>  129
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  129

Val Ala Asp Ser Ser 
1               5   


<210>  130
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  130

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly 
1               5                   10                  15      


Gly Phe Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ile Phe Asp Asp 
            20                  25                  30          


Thr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Val Ser Pro Ser Gly Val Ser Thr Asp Tyr Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val 
65                  70                  75                  80  


Phe Leu Gln Met Ser Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Leu Arg His Tyr Ser Asn Asp Gln His Glu Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  131
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  131

Gly Leu Ile Phe Asp Asp Thr Ala 
1               5               


<210>  132
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  132

Val Ser Pro Ser Gly Val Ser Thr 
1               5               


<210>  133
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  133

Ala Ala Arg Leu Arg His Tyr Ser Asn Asp Gln His Glu Tyr Asp Ser 
1               5                   10                  15      


<210>  134
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  134

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Val Phe Ser Ile 
            20                  25                  30          


Thr Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Thr Ile Ala Ser Gly Val Arg Ala Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Asn Arg Phe Ser Leu Gly Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  135
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  135

Gly Ile Val Phe Ser Ile Thr Thr 
1               5               


<210>  136
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  136

Ile Ala Ser Gly Val Arg Ala 
1               5           


<210>  137
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  137

Asn Ala Asn Arg Phe Ser Leu Gly Asn Tyr 
1               5                   10  


<210>  138
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  138

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ala 
            20                  25                  30          


Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Ile Ser Arg Ser Gly Ser Ser Thr His Tyr Ala Asn Ser 
    50                  55                  60                  


Val Lys Gly His Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Arg Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Glu Arg Thr Gly His Phe Thr Asp Leu Tyr Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  139
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  139

Gly Gly Thr Phe Ser Ala Tyr Thr 
1               5               


<210>  140
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  140

Ile Ser Arg Ser Gly Ser Ser Thr 
1               5               


<210>  141
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  141

Ala Gly Glu Arg Thr Gly His Phe Thr Asp Leu Tyr Tyr Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  142
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  142

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Ser Asn Phe Arg Ile 
            20                  25                  30          


Asn Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Thr Ile Ala Asn Ser Gly Arg Ile Asn Ser Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Gly Asn Ala Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Val Val Glu Ser Ser Asn Tyr Gln Thr Leu Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  143
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  143

Gly Ser Asn Phe Arg Ile Asn Thr 
1               5               


<210>  144
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  144

Ile Ala Asn Ser Gly Arg Ile 
1               5           


<210>  145
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  145

Asn Ala Asp Val Val Glu Ser Ser Asn Tyr Gln Thr Leu Asn Tyr 
1               5                   10                  15  


<210>  146
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  146

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Arg Ala Ser Gly Ser Ile 
            20                  25                  30          


Phe Gly Ala Gln Thr Met Ala Trp Tyr Arg Gln Ala Ser Gly Glu Arg 
        35                  40                  45              


Arg Glu Leu Val Ala Thr Ile Thr Ser Ser Gly Ser Thr Asn Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
65                  70                  75                  80  


Thr Met Phe Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Asn Val Gly Phe Arg Ser Arg Tyr Ser Tyr Asp Ser Ser 
            100                 105                 110         


Val Trp Gly Glu Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  147
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  147

Arg Ala Ser Gly Ser Ile Phe Gly Ala Gln Thr 
1               5                   10      


<210>  148
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  148

Ile Thr Ser Ser Gly Ser Thr 
1               5           


<210>  149
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  149

Asn Val Gly Phe Arg Ser Arg Tyr Ser Tyr Asp Ser Ser Val 
1               5                   10                  


<210>  150
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  150

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr 
            20                  25                  30          


Ser Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Gly Ala Ile Ser Pro Ser Gly Arg Ser Thr Asp Tyr Ala Ser Ser 
    50                  55                  60                  


Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Arg Ser Pro Ser Tyr Thr Arg Val Gly Asp Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  151
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  151

Gly Arg Thr Phe Ser Thr Ser Asn 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  152

Ile Ser Pro Ser Gly Arg Ser Thr 
1               5               


<210>  153
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  153

Ala Ala Arg Arg Ser Pro Ser Tyr Thr Arg Val Gly Asp Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  154
<211>  148
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  154

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ile 
            20                  25                  30          


Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ser Leu Ile Met Arg Ser Gly Gly Ile Ile Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Ser Thr Asn Ser Arg Ala Tyr Asn Tyr Tyr Lys Leu 
            100                 105                 110         


Ser Leu Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His 
    130                 135                 140                 


His His His His 
145             


<210>  155

<400>  155
000

<210>  156
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  156

Ile Met Arg Ser Gly Gly Ile Ile 
1               5               


<210>  157
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  157

Ala Ala Gly Gly Ser Thr Asn Ser Arg Ala Tyr Asn Tyr Tyr Lys Leu 
1               5                   10                  15      


Ser Leu Ala Tyr Asp Tyr 
            20          


<210>  158
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  158

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Thr 
            20                  25                  30          


Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Ile Ser Arg Thr Gly Arg Gly Thr Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Arg Ser Ser Val His Tyr Ser Gly Ile Ala Ala Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Ser Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  159
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  159

Gly Gly Thr Phe Ser Thr Tyr Thr 
1               5               


<210>  160
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  160

Ile Ser Arg Thr Gly Arg Gly Thr 
1               5               


<210>  161
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  161

Ala Glu Arg Ser Ser Val His Tyr Ser Gly Ile Ala Ala Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  162
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  162

Met Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Leu Ser Arg 
            20                  25                  30          


Ser Ala Met Gly Trp Phe Arg Gln Asn Pro Gly Glu Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Ile Asp Trp Trp Gly Asp Ser Thr Tyr Tyr Gly Asp Ser 
    50                  55                  60                  


Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly Leu Arg Pro Phe Asp Gly Ser Trp Glu Arg Arg Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  163
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  163

Gly Arg Asn Leu Ser Arg Ser Ala 
1               5               


<210>  164
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  164

Ile Asp Trp Trp Gly Asp Ser Thr 
1               5               


<210>  165
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  165

Ala Ala Gly Leu Arg Pro Phe Asp Gly Ser Trp Glu Arg Arg Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  166
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  166

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  167
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  167

Gly Ser Thr Phe Ser Gly Tyr Ile 
1               5               


<210>  168
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  168

Ile Thr Tyr Val Gly Ser Thr 
1               5           


<210>  169
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  169

Arg Ala Arg Glu Gly Glu Gln Leu Asp Phe 
1               5                   10  


<210>  170
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  171
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  171

Ser Gly Ser Thr Phe Ser Gly Tyr 
1               5               


<210>  172
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  172

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  173
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  173

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  174
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  174

Ala Ser Gly Ser Thr Phe Ser Gly Tyr Ile Met Ser 
1               5                   10          


<210>  175
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  175

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  176
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  176

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Thr Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  177
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  177

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Trp Tyr Gln Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  178
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  178

Ala Ile Thr Tyr Val Gly Ser Thr Trp Tyr Gln 
1               5                   10      


<210>  179
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  179

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Thr Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Asn Leu Asn Tyr Ile Asn 
            20                  25                  30          


Val Trp Ser Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Arg Val 
        35                  40                  45              


Ala Gly Ile Ala Thr Gly Gly Gly Arg Ile Ser Tyr Ser Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp Ala Thr Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Phe Gly Ser Asp Pro Asp Phe Ser Asp Tyr Lys His Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  180
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  180

Gly Asn Leu Asn Tyr Ile Asn Val 
1               5               


<210>  181
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  181

Ile Ala Thr Gly Gly Gly Arg Ile 
1               5               


<210>  182
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  182

Asn Ala Phe Gly Ser Asp Pro Asp Phe Ser Asp Tyr Lys His Asp Tyr 
1               5                   10                  15      


<210>  183
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  183

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  184

<400>  184
000

<210>  185
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  185

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Ser Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Tyr Val Gly Ser Thr Tyr Val Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Glu Gly Glu Gln Leu Asp Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  186
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  186

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ser Ala Lys 
            20                  25                  30          


Ala Leu Gly Trp His Arg Gln Ala Pro Gly Lys Gln Arg Glu Val Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Val Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Leu Tyr Asp Leu Ile Lys Asp Arg Thr Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  187
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  187

Gly Thr Ile Phe Ser Ala Lys Ala 
1               5               


<210>  188
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  188

Ile Thr Ser Gly Gly Ser Thr 
1               5           


<210>  189
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  189

Val Leu Tyr Asp Leu Ile Lys Asp Arg Thr Tyr 
1               5                   10      


<210>  190
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  190

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Thr Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Val Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Gly Asp Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Gly Arg Val Tyr Asn Gly Gly Trp Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Gly Ser His His His His His His 
    130                 135         


<210>  191
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  191

Thr Ser Ile Phe Ser Gly Thr 
1               5           


<210>  192
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  192

Ile Thr Ser Gly Asp Asn Thr 
1               5           


<210>  193
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  193

Arg Gly Arg Val Tyr Asn Gly Gly Trp Tyr Asp Tyr 
1               5                   10          


<210>  194
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  194

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ala Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Arg Arg Thr Tyr Ser Pro Arg Thr Leu Glu Tyr Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  195
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  195

Glu Arg Thr Phe Ser Ser Tyr Val 
1               5               


<210>  196
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  196

Ile Ser Trp Ser Gly Gly Ala Arg 
1               5               


<210>  197
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  197

Ala Ala Arg Arg Thr Tyr Ser Pro Arg Thr Leu Glu Tyr Asp Phe 
1               5                   10                  15  


<210>  198
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  198

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ala Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Arg Arg Thr Tyr Ser Pro Arg Thr Leu Glu Tyr Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  199
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  199

Gly Asp Thr Phe Ser Thr Tyr Val 
1               5               


<210>  200
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  200

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asn Thr Asp Gly Ile Gly Ser Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Lys Met Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Ala Ala Leu Thr Val Ile Arg Gly Arg Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  201
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  201

Gly Phe Thr Phe Ser Asp Tyr Val 
1               5               


<210>  202
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  202

Ile Asn Thr Asp Gly Ile Gly Ser 
1               5               


<210>  203
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  203

Ala Arg Gly Asn Ala Ala Leu Thr Val Ile Arg Gly Arg Pro 
1               5                   10                  


<210>  204
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  204

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asn Thr Asp Gly Asn Gly Ser Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Met Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Ala Ala Leu Ser Leu Ile Arg Gly Arg Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  205
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  205

Ile Asn Thr Asp Gly Asn Gly Ser 
1               5               


<210>  206
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  206

Ala Lys Gly Asn Ala Ala Leu Ser Leu Ile Arg Gly Arg Pro 
1               5                   10                  


<210>  207
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  207

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Gly Arg Gly Asn Thr Tyr Tyr Gly Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Arg Ala Tyr Val Ser Gly Asn Tyr Tyr Ser Ala 
            100                 105                 110         


Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  208
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  208

Gly Arg Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  209
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  209

Ile Ser Trp Gly Arg Gly Asn Thr 
1               5               


<210>  210
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  210

Ala Ala Asp Pro Gly Arg Ala Tyr Val Ser Gly Asn Tyr Tyr Ser Ala 
1               5                   10                  15      


Ala Thr Tyr Asp Tyr 
            20      


<210>  211
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  211

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Phe Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Gly Arg Gly Asn Thr Tyr Tyr Gly Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Arg Ala Tyr Val Ser Gly Asn Tyr Tyr Ser Ala 
            100                 105                 110         


Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  212
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  212

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  213
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  213

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Gly Arg Gly Asn Thr Tyr Tyr Gly Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Arg Ala Tyr Val Ser Gly Asn Tyr Tyr Ser Ala 
            100                 105                 110         


Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  214
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  214

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Thr Ile 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Glu Met Glu Arg Gly Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Arg Gly Thr Tyr Thr Tyr Tyr Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Pro Gly Ile Ser Ala Tyr Trp Gly Asp Leu Ser Asn 
            100                 105                 110         


Trp Lys Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  215
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  215

Gly Gly Ser Phe Ser Thr Ile Pro 
1               5               


<210>  216
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  216

Ile Ser Tyr Arg Gly Thr Tyr Thr 
1               5               


<210>  217
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  217

Ala Ala Gly Ser Pro Gly Ile Ser Ala Tyr Trp Gly Asp Leu Ser Asn 
1               5                   10                  15      


Trp Lys Asn 
            


<210>  218
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  218

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ser Phe Ser Ser His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Asn Ser Gly Ser Thr Phe Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ser Gly Arg Gly Ile Thr Ala Ser Ala Phe Arg Tyr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  219
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  219

Gly Arg Ser Phe Ser Ser His Ala 
1               5               


<210>  220
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  220

Ile Ser Trp Asn Ser Gly Ser Thr 
1               5               


<210>  221
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  221

Ala Ala Ala Ser Gly Arg Gly Ile Thr Ala Ser Ala Phe Arg Tyr Asp 
1               5                   10                  15      


Val 
    


<210>  222
<211>  148
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  222

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Ser Ile Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Arg Ile Phe Gly Ser Gly Ser Tyr Tyr Gly Asn 
            100                 105                 110         


Arg Asn Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His 
    130                 135                 140                 


His His His His 
145             


<210>  223
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  223

Gly Arg Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  224
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  224

Ile Arg Trp Ser Gly Ser Ile Thr 
1               5               


<210>  225
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  225

Ala Ala Asp Pro Gly Arg Ile Phe Gly Ser Gly Ser Tyr Tyr Gly Asn 
1               5                   10                  15      


Arg Asn Thr Tyr Asp Tyr 
            20          


<210>  226
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  226

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Glu Arg Thr Phe Arg Thr Tyr 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Asn Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asn Cys 
                85                  90                  95      


Ala Ala Arg Ala Pro Ser Gly Gly Tyr Tyr Tyr Pro Asn Ala Leu Ser 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His 
    130                 135                 140                 


His His 
145     


<210>  227
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  227

Glu Arg Thr Phe Arg Thr Tyr Thr 
1               5               


<210>  228
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  228

Ile Arg Trp Asn Gly Asp Ser Thr 
1               5               


<210>  229
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  229

Ala Ala Arg Ala Pro Ser Gly Gly Tyr Tyr Tyr Pro Asn Ala Leu Ser 
1               5                   10                  15      


Glu Tyr Asn Tyr 
            20  


<210>  230
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  230

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Arg Thr Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Asn Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Arg Ala Tyr Ser Ile Gly Tyr Tyr Tyr Pro Asn Ala Leu Ser 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His 
    130                 135                 140                 


His His 
145     


<210>  231
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  231

Ala Ala Ser Glu Arg Thr Phe Arg Thr Tyr Thr Met Gly 
1               5                   10              


<210>  232
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  232

Ala Ala Arg Ala Tyr Ser Ile Gly Tyr Tyr Tyr Pro Asn Ala Leu Ser 
1               5                   10                  15      


Glu Tyr Asn Tyr 
            20  


<210>  233
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  233

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Ile Ser Arg Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Leu Ile Arg Trp Ser Asn Gly Asn Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Ser Gly Tyr Val Gly Ser Ala Tyr Ser Gln Gln Ala 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  234
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  234

Gly Val Thr Ile Ser Arg Tyr Thr 
1               5               


<210>  235
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  235

Ile Arg Trp Ser Asn Gly Asn Thr 
1               5               


<210>  236
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  236

Ala Thr Leu Arg Ser Gly Tyr Val Gly Ser Ala Tyr Ser Gln Gln Ala 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  237
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  237

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Ser Thr Val Ser Asp Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Asp Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Val Phe Lys Ala Thr Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  238
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  238

Thr Ser Thr Val Ser Asp Tyr His 
1               5               


<210>  239
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  239

Ile Ser Trp Ser Gly Asp Ser Thr 
1               5               


<210>  240
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  240

Ala Ala Arg Arg Val Phe Lys Ala Thr Trp Asp Tyr 
1               5                   10          


<210>  241
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  241

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Thr Val Arg Ile Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Ile Thr Trp Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Arg Ser Tyr Val Leu Ser Arg Tyr Tyr Asp Gln 
            100                 105                 110         


Ala Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  242
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  242

Val Arg Ile Phe Ser Ser Tyr Thr 
1               5               


<210>  243
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  243

Ile Thr Trp Ser Gly Gly Asn Thr 
1               5               


<210>  244
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  244

Ala Ala Asp Pro Gly Arg Ser Tyr Val Leu Ser Arg Tyr Tyr Asp Gln 
1               5                   10                  15      


Ala Ser Tyr Asp Tyr 
            20      


<210>  245
<211>  148
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  245

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Val Gly Arg Ile Tyr Gly Gly Gly Ser Leu Tyr Ser Ser 
            100                 105                 110         


Ala Phe Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His 
    130                 135                 140                 


His His His His 
145             


<210>  246
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  246

Gly Arg Pro Phe Ser Ser Tyr Thr 
1               5               


<210>  247
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  247

Ile Ser Trp Ser Gly Gly Thr Thr 
1               5               


<210>  248
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  248

Ala Thr Asp Val Gly Arg Ile Tyr Gly Gly Gly Ser Leu Tyr Ser Ser 
1               5                   10                  15      


Ala Phe Ser Tyr Asp Tyr 
            20          


<210>  249
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  249

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Gly Gly Asp Lys Ile Ser Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Leu Arg Asp Asn Thr Lys Asp Thr Thr Ser 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Trp Gly Tyr Lys Thr Gly Pro Thr Tyr Ser Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  250
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  250

Gly Gly Thr Phe Ser Asp Tyr Val 
1               5               


<210>  251
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  251

Ile Asn Tyr Gly Gly Asp Lys Ile 
1               5               


<210>  252
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  252

Ala Ala Lys Trp Gly Tyr Lys Thr Gly Pro Thr Tyr Ser Tyr 
1               5                   10                  


<210>  253
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  253

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Val 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Tyr Asp Gly Arg Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His 
        115                 120                 125             


His His His His 
    130         


<210>  254
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  254

Gly Arg Thr Phe Ser Asn Val Ala 
1               5               


<210>  255
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  255

Ile Ser Gly Ser Gly Gly Thr Thr 
1               5               


<210>  256
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  256

Ser Thr Tyr Asp Gly Arg 
1               5       


<210>  257
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  257

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Ala Ile Thr Thr Ala Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Gly Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Tyr Ser Ser Gly Ser Tyr Tyr Tyr Ala Arg Thr Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  258
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  258

Gly Leu Thr Phe Ser Arg Asn Ala 
1               5               


<210>  259
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  259

Ile Ser Trp Asn Ala Ile Thr Thr Ala 
1               5                   


<210>  260
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  260

Ala Ala Arg Tyr Ser Ser Gly Ser Tyr Tyr Tyr Ala Arg Thr Tyr Glu 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  261
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  261

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ala Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Thr Val Leu Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  262
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  262

Gly Arg Thr Ser Arg Ser Tyr Ala 
1               5               


<210>  263
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  263

Ile Ala Trp Ser Asp Gly Arg Ile 
1               5               


<210>  264
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  264

Ala Ser Arg Ala Arg Gly Thr Val Leu Tyr Asn Tyr 
1               5                   10          


<210>  265
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  265

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu His Val 
        35                  40                  45              


Ala Asp Ile Ala Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Thr Val Ser Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  266
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  266

Ala Ser Arg Ala Arg Gly Thr Val Ser Tyr Asn Tyr 
1               5                   10          


<210>  267
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  267

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ala Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Thr Val Leu Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  268
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  268

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ala Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Thr Val Ser Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  269
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  269

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ser Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Ser Val Leu Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  270
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  270

Ile Ser Trp Ser Asp Gly Arg Ile 
1               5               


<210>  271
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  271

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ala Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Thr Val Ser Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  272
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  272

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ala Trp Ser Asp Gly Arg Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Asp Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ala Arg Gly Thr Val Ser Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  273
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  273

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Tyr Ser Gly Asn Val Phe Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Asn Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  274
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  274

Gly Asn Val Phe Ser Ile Asn Leu 
1               5               


<210>  275
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  275

Ile Asn Arg Gly Gly Arg Thr 
1               5           


<210>  276
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  276

Ala Ala Ser Arg Asp Pro Tyr Thr Gly Tyr 
1               5                   10  


<210>  277
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  277

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Tyr Ser Gly Asn Val Phe Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Asn Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Glu Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  278
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  278

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Tyr Ser Gly Asn Val Phe Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Asn Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  279
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  279

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val Asp Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Asn Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  280
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  280

Gly Ser Val Asp Ser Ile Asn Leu 
1               5               


<210>  281
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  281

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Pro Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Tyr Ser Gly Asn Val Phe Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Asn Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  282
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  282

Asn Val Phe Ser Ile Asn Leu 
1               5           


<210>  283
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  283

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Tyr Ser Gly Asn Val Phe Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Thr Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Ser Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  284
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  284

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Tyr Ser Gly Asn Val Phe Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Gly Ile Thr Arg Gly Gly Arg Thr Asn Tyr Thr Asp Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Asp Pro Tyr Thr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  285
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  285

Cys Ala Ala Ser Arg Asp Pro Tyr Thr Gly Tyr 
1               5                   10      


<210>  286
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  286

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Lys Arg Ser Phe Ser Ser His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Asn Ser Gly Ser Thr Phe Tyr Ser Asp Ser Ser 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ser Gly Arg Gly Ile Thr Ala Ser Asp Phe Arg Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  287
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  287

Lys Arg Ser Phe Ser Ser His Ala 
1               5               


<210>  288

<400>  288
000

<210>  289
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  289

Ala Ala Ala Ser Gly Arg Gly Ile Thr Ala Ser Asp Phe Arg Tyr Asp 
1               5                   10                  15      


Ala 
    


<210>  290
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  290

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Arg Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Asn Ser Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ser Gly Arg Gly Ile Thr Ala Ser Asp Phe Arg Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  291
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  291

Gly Arg Thr Phe Ser Ser His Ala 
1               5               


<210>  292
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  292

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ser Phe Ser Arg His 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Asn Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ser Gly Arg Gly Ile Thr Ala Ser Asp Phe Arg Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  293
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  293

Gly Arg Ser Phe Ser Arg His Ala 
1               5               


<210>  294
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  294

Ile Ser Trp Asn Ala Gly Ser Thr 
1               5               


<210>  295
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  295

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Ile 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Trp Asn Ser Ile Ala Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Ala Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Ala Pro Phe Arg Ser Lys Asn Pro Thr Leu Tyr Leu Tyr Trp 
            100                 105                 110         


Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  296
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  296

Gly Arg Thr Phe Ser Arg Ile Asn 
1               5               


<210>  297
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  297

Ile Ser Trp Asn Ser Ile Ala 
1               5           


<210>  298
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  298

Ala Ala Ser Ala Pro Phe Arg Ser Lys Asn Pro Thr Leu Tyr Leu Tyr 
1               5                   10                  15      


<210>  299
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  299

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Asn Pro Val 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Xaa Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Thr Ile Thr Trp Gly Ile Gly Ser Thr His Tyr Ala Val Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Glu Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Ser Leu Leu Arg Arg Ala Asp Glu Ile Pro Ser Val 
            100                 105                 110         


Ala Asn Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  300
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  300

Gly Arg Thr Phe Asn Pro Val Ala 
1               5               


<210>  301
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  301

Ile Thr Trp Gly Ile Gly Ser Thr 
1               5               


<210>  302
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  302

Ala Ala Arg Thr Ser Leu Leu Arg Arg Ala Asp Glu Ile Pro Ser Val 
1               5                   10                  15      


Ala Asn Tyr Asp Ser 
            20      


<210>  303
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  303

Gln Val Xaa Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Met Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Lys Ile Ser Thr Ser Gly Arg Tyr Thr Asp Tyr Val Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Leu Ser Arg Asp Asn Val Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Leu Pro Arg Pro Asp Thr Trp Ser Gln Gly Lys Thr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  304
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  304

Gly Arg Thr Phe Ser Met Tyr Thr 
1               5               


<210>  305
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  305

Ile Ser Thr Ser Gly Arg Tyr Thr 
1               5               


<210>  306
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  306

Ala Ala Arg Leu Pro Arg Pro Asp Thr Trp Ser Gln Gly Lys Thr Asp 
1               5                   10                  15      


Tyr 
    


<210>  307
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  307

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Asn 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Xaa Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Lys Thr Gly Gly Asn Ser Gly Ile Thr Val Tyr Ser Asn Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Leu Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Gly Leu Lys Leu Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ser Gly Thr Pro Leu Ala Leu Arg Ser Glu Lys Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  308
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  308

Gly Arg Thr Phe Ser Asn Asn Pro 
1               5               


<210>  309
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  309

Lys Thr Gly Gly Asn Ser Gly Ile Thr 
1               5                   


<210>  310
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  310

Ala Ala Ser Gly Thr Pro Leu Ala Leu Arg Ser Glu Lys Asn Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  311
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  311

Gln Val Xaa Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Pro Asn His Arg Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Val Pro Ala Ser Arg Ala Gly Gly Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  312
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  312

Gly Ser Ile Phe Asn Ile Asn Thr 
1               5               


<210>  313
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  313

Ile Ser Ser Asp Gly Arg Pro 
1               5           


<210>  314
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  314

Asn Thr Val Pro Ala Ser Arg Ala Gly Gly Tyr 
1               5                   10      


<210>  315
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  315

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Ile Asp Asn Gly 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Val Lys His Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Lys Ser Ile Gly Thr Tyr Ser Ser Ser Ser Ala Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  316
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  316

Gly Arg Thr Ile Asp Asn Gly Ala 
1               5               


<210>  317
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  317

Ile Asn Trp Ser Gly Ser Ser Thr 
1               5               


<210>  318
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  318

Ala Ala Ala Lys Ser Ile Gly Thr Tyr Ser Ser Ser Ser Ala Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  319
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  319

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  320
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  320

Gly Arg Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  321
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  321

Met Asn Arg Asp Gly Ser Thr Val 
1               5               


<210>  322
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  322

Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Val 
1               5                   10                  15      


Ser 
    


<210>  323
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  323

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Ile Leu Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr His Gly Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  324
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  324

Met Asn Arg Asp Gly Ser Thr Ile 
1               5               


<210>  325
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  325

Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr His Gly Gln Ser Phe Val 
1               5                   10                  15      


Ser 
    


<210>  326
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  326

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Ile 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  327
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  327

Gly Arg Thr Phe Asp Ala Tyr Ala 
1               5               


<210>  328
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  328

Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Ile 
1               5                   10                  15      


Ser 
    


<210>  329
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  329

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  330

<400>  330
000

<210>  331
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  331

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Glu Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  332
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  332

Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Glu Gln Ser Phe Val 
1               5                   10                  15      


Ser 
    


<210>  333
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  333

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Ser Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  334
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  334

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Pro Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Ser Arg Gly Ser Thr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Lys 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  335

<400>  335
000

<210>  336
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  336

Met Asn Ser Arg Gly Ser Thr Ile 
1               5               


<210>  337
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  337

Ala Ala Asp Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  338
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  338

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asn Gly His Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  339
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  339

Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asn Gly His Ser Phe Val 
1               5                   10                  15      


Ser 
    


<210>  340
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  340

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Arg Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  341
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  341

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asp Gly Ser Thr Val Leu Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Arg Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ala Arg Tyr Ser Asp Tyr Thr Asp Gly Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  342
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  342

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Glu Arg Ser Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Asn Arg Asn Gly Asn Thr Ile Asn Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Ser Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser Ala Asn Ala Arg Leu Ser Asp Tyr Thr Asn Pro Gln Ser Phe Val 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  343
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  343

Glu Arg Ser Phe Ser Thr Tyr Ala 
1               5               


<210>  344
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  344

Met Asn Arg Asn Gly Asn Thr Ile 
1               5               


<210>  345
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  345

Ser Ala Asn Ala Arg Leu Ser Asp Tyr Thr Asn Pro Gln Ser Phe Val 
1               5                   10                  15      


Ser 
    


<210>  346
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  346

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asn Gly Arg Ser Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Gly Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Gln Ser Met Lys Gly Tyr Glu Tyr Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  347
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  347

Gly Arg Ala Phe Ser Ser Tyr Gly 
1               5               


<210>  348
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  348

Ile Asn Ser Asn Gly Arg Ser Thr 
1               5               


<210>  349
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  349

Ala Ala Asp Arg Gln Ser Met Lys Gly Tyr Glu Tyr Gly Tyr 
1               5                   10                  


<210>  350
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  350

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asn Gly Arg Ser Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Lys Ser Met Thr Gly Tyr Glu Tyr Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  351
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  351

Gly Arg Ala Phe Ser Arg Tyr Gly 
1               5               


<210>  352
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  352

Ile Thr Ser Asn Gly Arg Ser Thr 
1               5               


<210>  353
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  353

Ala Ala Asp Arg Lys Ser Met Thr Gly Tyr Glu Tyr Gly Tyr 
1               5                   10                  


<210>  354
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  354

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asn Gly Arg Ser Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Lys Ser Met Thr Gly Tyr Glu Tyr Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  355
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  355

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Ile Asn Ser Asn Gly Arg Ser Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Gln Ser Met Thr Arg Tyr Glu Tyr Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  356
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  356

Ala Ala Asp Arg Gln Ser Met Thr Arg Tyr Glu Tyr Gly Tyr 
1               5                   10                  


<210>  357
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  357

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Val Ser Gly Ile Ala Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Gly Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asn Asp Tyr 
            100                 105                 110         


Gly Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  358
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  358

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  359
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  359

Val Ser Gly Ile Ala Arg Arg Thr 
1               5               


<210>  360
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  360

Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asn Asp Tyr 
1               5                   10                  15      


Gly Tyr 
        


<210>  361
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  361

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Val Ser Gly Ile Ala Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Gly Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asp Asp Tyr 
            100                 105                 110         


Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  362
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  362

Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asp Asp Tyr 
1               5                   10                  15      


Gly Tyr 
        


<210>  363
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  363

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Val Ser Gly Ile Ala Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Gly Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asn Asp Tyr 
            100                 105                 110         


Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  364
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  364

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Gly Ile Ala Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Gly Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asn Asp Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  365
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  365

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  366
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  366

Ala Arg Ala Thr Ser Arg Met Thr Ser Val Thr Thr Leu Asn Asp Tyr 
1               5                   10                  15      


Ala Tyr 
        


<210>  367
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  367

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ser Ala Ser Gly Ser Leu Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Arg Lys Gln His Glu Leu Val 
        35                  40                  45              


Ala Thr Met Met Asp Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Val 
                85                  90                  95      


Ala Asp Arg Leu Gly Ser Gly Arg Tyr Ala Tyr Gly Ile Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  368
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  368

Gly Ser Leu Phe Ser Ile Asn Ala 
1               5               


<210>  369
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  369

Met Met Asp Gly Gly Ser Thr 
1               5           


<210>  370
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  370

Val Ala Asp Arg Leu Gly Ser Gly Arg Tyr Ala Tyr Gly Ile Asp Tyr 
1               5                   10                  15      


<210>  371
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  371

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Arg Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Met Met Asp Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Val 
                85                  90                  95      


Ala Asp Arg Leu Gly Ser Gly Arg Tyr Ala Tyr Gly Ile Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  372
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  372

Gly Ser Ile Phe Ser Ile Asn Ala 
1               5               


<210>  373
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  373

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Val Ser Ile Asn 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ala Pro Arg Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Met Met Asp Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Arg Leu Gly Ser Gly Arg Tyr Ala Tyr Ala Ile Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  374
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  374

Gly Ser Ile Val Ser Ile Asn Gly 
1               5               


<210>  375
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  375

Ala Ala Asp Arg Leu Gly Ser Gly Arg Tyr Ala Tyr Ala Ile Asp Tyr 
1               5                   10                  15      


<210>  376
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  376

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Val Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Phe Arg Gln Val Ala Gly Lys Glu Arg Ala Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Asn Arg Gly Asp Ser Lys Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Val Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Ser Leu Val Arg Tyr Glu Tyr Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  377
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  377

Gly Arg Thr Val Ser Asn Tyr Gly 
1               5               


<210>  378
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  378

Ile Asn Asn Arg Gly Asp Ser Lys 
1               5               


<210>  379
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  379

Ala Ala Asp Arg Arg Ser Leu Val Arg Tyr Glu Tyr Asn Tyr 
1               5                   10                  


<210>  380
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  380

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Gly Asn Thr Tyr Tyr Thr Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ala Asp Asp Gly Leu Ser Tyr Ala Ser Ser Ser Tyr Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  381
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  381

Gly Arg Thr Phe Ser Arg Tyr Thr 
1               5               


<210>  382
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  382

Ile Arg Trp Ser Ser Gly Asn Thr 
1               5               


<210>  383
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  383

Val Ala Asp Asp Gly Leu Ser Tyr Ala Ser Ser Ser Tyr Leu Tyr 
1               5                   10                  15  


<210>  384
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  384

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Gly Asn Thr Tyr Tyr Thr Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ala Asp Asp Gly Leu Ser Tyr Ala Ser Ser Ser Tyr Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  385
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  385

Gly Phe Thr Phe Ser Arg Tyr Thr 
1               5               


<210>  386
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  386

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Gly Asn Tyr 
            20                  25                  30          


Gly Leu Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Asn Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Thr Ser Leu His Ser Tyr Arg Tyr Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  387
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  387

Gly Arg Thr Phe Gly Asn Tyr Gly 
1               5               


<210>  388
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  388

Ile Asn Asn Arg Gly Gly Asn Thr 
1               5               


<210>  389
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  389

Ala Ala Asp Arg Thr Ser Leu His Ser Tyr Arg Tyr Thr Tyr 
1               5                   10                  


<210>  390
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  390

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Gly Asn Tyr 
            20                  25                  30          


Gly Leu Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Thr Ser Leu His Ser Tyr Arg Tyr Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  391
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  391

Ile Ser Asn Arg Gly Gly Asn Thr 
1               5               


<210>  392
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  392

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Pro Lys Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Gly Asn Tyr 
            20                  25                  30          


Gly Leu Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Thr Ser Leu His Ser Tyr Arg Tyr Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  393
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  393

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ser Arg Ile Asn Trp Asn Gly Gly Phe Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ala Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Cys Gly Ser Ala Tyr Pro Cys Arg Pro Glu Glu Tyr Thr Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  394
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  394

Glu Arg Thr Phe Ser Thr Tyr Asn 
1               5               


<210>  395
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  395

Ile Asn Trp Asn Gly Gly Phe Thr 
1               5               


<210>  396
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  396

Ala Ala Cys Gly Ser Ala Tyr Pro Cys Arg Pro Glu Glu Tyr 
1               5                   10                  


<210>  397
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  397

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ser Ser Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asn Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Ser Arg Ala Pro Arg Thr Tyr Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  398
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  398

Gly Arg Thr Leu Ser Ser Tyr Thr 
1               5               


<210>  399
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  399

Ser Ser Trp Ser Gly Gly Arg Thr 
1               5               


<210>  400
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  400

Ala Ala Asp Ser Ser Arg Ala Pro Arg Thr Tyr Asn Tyr 
1               5                   10              


<210>  401
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  401

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Asn Met Ser Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Ile Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Arg Val Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Asn Ser Arg Arg Ser Arg Asp Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  402
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  402

Gly Arg Thr Phe Ser Thr Tyr Asn 
1               5               


<210>  403
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  403

Ile Ser Trp Ser Gly Arg Val Thr 
1               5               


<210>  404
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  404

Ala Ala Asp Ser Asn Ser Arg Arg Ser Arg Asp Tyr Asp Tyr 
1               5                   10                  


<210>  405
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  405

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Thr Arg Arg Ile Asn 
            20                  25                  30          


Ser Met Arg Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Asp Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Glu Gly Gly Phe Thr Ala Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Ala Tyr Leu Gly Ala Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  406
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  406

Gly Thr Thr Arg Arg Ile Asn Ser 
1               5               


<210>  407
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  407

Ile Thr Glu Gly Gly Phe Thr 
1               5           


<210>  408
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  408

Tyr Leu Gly Ala Ala Tyr 
1               5       


<210>  409
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  type 2 chitin-binding domain (ChtBD2)


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(62)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (116)..(121)
<223>  Xaa can be any naturally occurring amino acid

<400>  409

Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Cys Cys Cys 
1               5                   10                  15      


Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys 
            20                  25                  30          


Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Xaa Xaa Xaa Xaa Xaa Cys 
        35                  40                  45              


Cys Cys Cys Cys Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Cys 
    50                  55                  60                  


Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys 
65                  70                  75                  80  


Cys Cys Cys Cys Cys Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys 
            100                 105                 110         


Cys Cys Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Cys Cys Cys Cys Cys Cys 
        115                 120                 125             


Cys Cys Cys Cys Cys 
    130             


<210>  410
<211>  1137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  type 2 chitin-binding domain (ChtBD2)

<400>  410

Met Lys Asp Ala Val Ile Leu Leu Leu Cys Ala Ile Ala Leu Ala Asp 
1               5                   10                  15      


Gly Phe Asn His Glu Leu Leu Ser Asn Ser Arg Ser Cys Asn Cys Asn 
            20                  25                  30          


Pro Ser Glu Ala Gln Gln Ile Cys Glu Ala Asn Tyr Gly Lys Asp Asp 
        35                  40                  45              


Val Leu Ile Ala His Glu Asn Cys Asp Lys Phe Tyr Lys Cys Ala Asn 
    50                  55                  60                  


Gly Lys Pro Phe Pro Tyr Lys Cys Pro Asn Asn Leu Leu Tyr Asp Pro 
65                  70                  75                  80  


Tyr Lys Glu Glu Cys Glu Trp Pro Trp Leu Val Asp Cys Gly Asp Arg 
                85                  90                  95      


Pro Ile Ser Glu Gly Ser Asp Gln Glu Asp Gly Gly Val Asp Asn Asp 
            100                 105                 110         


Asn Asn Asp Ser Asn Asp Asn Asn Gly Val Asp Asp Gly Trp Thr Cys 
        115                 120                 125             


Asn Cys Asn Pro Ser Glu Ala Pro Ser Ile Cys Ala Ala Glu Gly Ser 
    130                 135                 140                 


Ser Gly Val Leu Val Ala His Glu Asn Cys Asp Gln Phe Tyr Met Cys 
145                 150                 155                 160 


Asp Ala Gly Arg Pro Val Thr Phe Asp Cys Pro Pro Thr Leu Met Tyr 
                165                 170                 175     


Asp Pro His Arg Glu Glu Cys Tyr Trp Pro His Glu Val Asp Cys Gly 
            180                 185                 190         


Asp Arg Gly Ile Ser Glu Pro Gly Asn Asp Gln Gly Asn Asp Asn Asp 
        195                 200                 205             


Gly Asn Asp Asn Asn Ser Ser Asn Glu Gln Gly Gly Val Cys Asn Cys 
    210                 215                 220                 


Asn Pro Glu Glu Ala Pro Ala Ile Cys Ala Ser Pro Gly Ser Glu Gly 
225                 230                 235                 240 


Val Leu Val Ala His Glu Asn Cys Glu Lys Tyr Tyr Ile Cys Asn His 
                245                 250                 255     


Gly Arg Pro Val Val Ala Ser Cys Ser Gly Asn Leu Leu Phe Asn Pro 
            260                 265                 270         


Tyr Thr Asn Glu Cys Gly Trp Pro Arg Asp Val Asp Cys Gly Asp Arg 
        275                 280                 285             


Ile Glu Pro Gly Cys Thr Gly Cys Asn Asp Asn Asn Asn Asn Asp Asp 
    290                 295                 300                 


Asn Asp Ser Asp Cys Asp Gly Asp Asp Pro Val Pro Pro Pro Ala Asp 
305                 310                 315                 320 


Asn Asp Asp Ser Glu Ser Ala Asp Ile Asp Asp Leu Pro Pro Pro Gly 
                325                 330                 335     


Asp Asp Ala Ser Val Arg Pro Pro Val Asp Glu Gly Thr Cys Asn Cys 
            340                 345                 350         


Asn Pro Glu Gln Ala Pro Ser Ile Cys Ala Glu Asp Asp Ser Asp Gly 
        355                 360                 365             


Val Leu Val Ala His Glu Asp Cys Asn Lys Phe Tyr Lys Cys His Asn 
    370                 375                 380                 


Gly Lys Pro Val Ala Leu Tyr Cys Pro Gly Asn Leu Leu Tyr Asn Pro 
385                 390                 395                 400 


Asn Thr Glu Gln Cys Asp Trp Pro Glu Lys Val Asp Cys Gly Asp Arg 
                405                 410                 415     


Val Ile Pro Asp Pro Glu Asp Asn Asn Asn Asn Asp Ser Ser Gly Gly 
            420                 425                 430         


Asn Asn Asp Gly Gly Asn Asp Gly Gly Asn Gly Gly Gly Gly Asn Cys 
        435                 440                 445             


Asp Pro Ser Glu Ala Pro Ala Ile Cys Ala Glu Asp Asp Ser Glu Gly 
    450                 455                 460                 


Val Leu Val Ala His Glu Asn Cys Asn Gln Phe Tyr Lys Cys Ser Gly 
465                 470                 475                 480 


Gly Lys Pro Val Ala Leu Leu Cys Pro Gly Asn Leu Leu Phe Asn Pro 
                485                 490                 495     


Asn Thr Asp Gln Cys Asp Trp Pro Trp Glu Val Asp Cys Gly Asp Arg 
            500                 505                 510         


Ile Ile Pro Asp Pro Asp Gln Lys Pro Asp Pro Glu Asp Ser Ser Asp 
        515                 520                 525             


Asp Ser Ser Ala Asp Ile Asp Asp Leu Pro Pro Pro Gly Asp Asp Val 
    530                 535                 540                 


Thr Thr Arg Pro Pro Gly Thr Cys Asn Cys Asn Pro Glu Glu Ala Pro 
545                 550                 555                 560 


Ser Ile Cys Ala Gln Asp Gly Ser Asn Gly Thr Leu Ile Ala His Glu 
                565                 570                 575     


Asp Cys Asn Lys Phe Tyr Ile Cys Asp His Gly Lys Pro Val Ala Leu 
            580                 585                 590         


Ser Cys Pro Gly Asn Leu Leu Tyr Asn Pro Tyr Thr Glu Lys Cys Asp 
        595                 600                 605             


Trp Pro Glu Asn Val Glu Cys Gly Asp Ser Asp Gly Ile Leu Ile Ala 
    610                 615                 620                 


His Glu Asp Cys Asn Lys Phe Tyr Ile Cys Asp His Gly Lys Pro Val 
625                 630                 635                 640 


Val Leu Ser Cys Pro Gly Asn Leu Phe Tyr Asn Pro Tyr Thr Glu Gln 
                645                 650                 655     


Cys Asp Trp Pro Val Asn Val Glu Cys Gly Asp Arg Val Thr Pro Asp 
            660                 665                 670         


Pro Asp Ala Thr Pro Ala Pro Thr Ala Ala Pro Thr Ser Thr Thr Thr 
        675                 680                 685             


Val Ala Pro Thr Ala Ala Pro Ser Thr Thr Thr Thr Val Ala Pro Thr 
    690                 695                 700                 


Ala Ala Pro Thr Thr Thr Thr Thr Val Ala Pro Thr Thr Thr Thr Thr 
705                 710                 715                 720 


Val Ala Pro Thr Thr Thr Thr Thr Val Ala Pro Thr Ala Ala Pro Thr 
                725                 730                 735     


Thr Thr Thr Thr Val Ala Pro Thr Ala Ala Pro Thr Thr Thr Thr Thr 
            740                 745                 750         


Val Ala Pro Thr Ala Ala Pro Thr Thr Thr Thr Thr Val Ala Ser Thr 
        755                 760                 765             


Ala Ala Pro Thr Ala Ala Pro Thr Ala Ala Pro Thr Ala Ala Ser Thr 
    770                 775                 780                 


Pro Asp Asp Ser Asp Cys Asp Asp Asp Asn Asn Gly Gly Asp Asp Thr 
785                 790                 795                 800 


Cys Asn Cys Asn Pro Asp Glu Ala Ala Ser Ile Cys Ser Val Gly Asn 
                805                 810                 815     


Ser Asp Gly Ile His Val Ala His Glu Asn Cys Asn Trp Phe Tyr Lys 
            820                 825                 830         


Cys Asp Asn Gly Arg Pro Val Pro Phe Arg Cys Pro Ser Gly Leu Met 
        835                 840                 845             


Tyr Asn Pro Tyr Thr Gln Ile Cys Asp Trp Pro Trp Asp Val Glu Cys 
    850                 855                 860                 


Gly Asp Arg Val Ile Ala Asp Asp Asp Asp Ser Ser Glu Glu Asp Asn 
865                 870                 875                 880 


Asp Asn Asp Asn Asp Ser Gly Val Val Gly Pro Cys Asn Cys Asn Pro 
                885                 890                 895     


Glu Glu Ala Pro Ala Ile Cys Ala Ala Glu Gly Ser Asn Gly Val His 
            900                 905                 910         


Val Ala His Gln Asn Cys Asn Gln Tyr Tyr Met Cys Asp Asn Gly Arg 
        915                 920                 925             


Pro Val Ala Phe Thr Cys Asn Gly Phe Leu Leu Tyr Asn Pro Tyr Thr 
    930                 935                 940                 


Gln Gln Cys Asp Trp Pro His Leu Val Glu Cys Gly Asp Arg Val Ile 
945                 950                 955                 960 


Pro Glu Pro Gly Asp Glu Asp Asp Glu Asp Cys Asp Asp Asp Asp Asp 
                965                 970                 975     


Asn Ser Asn Asn Val Ile Asn Asp Asp Pro Ser Gln Ala Pro Ala Ile 
            980                 985                 990         


Cys Ala Asp Ser Gly Ser Glu Gly  Val Leu Val Ala His  Glu Asn Cys 
        995                 1000                 1005             


Asp Gln  Tyr Tyr Ile Cys Asp  Gly Gly Arg Pro Val  Ala Arg Pro 
    1010                 1015                 1020             


Cys Gln  Gly Gly Leu Leu Tyr  Asn Pro Leu Thr Gln  Tyr Cys Asp 
    1025                 1030                 1035             


Trp Pro  Gly Asn Val Asn Cys  Gly Asp Arg Ile Ile  Pro Asp Asp 
    1040                 1045                 1050             


Cys Ala  Cys Asn Pro Arg Asn  Ala Pro Arg Leu Cys  Ser Lys Pro 
    1055                 1060                 1065             


Asp Ser  Glu Gly Ser Leu Val  Ala His Glu Asn Cys  Asn Gln Phe 
    1070                 1075                 1080             


Tyr Ile  Cys Ala His Ser Val  Pro Val Glu His Phe  Cys Pro Val 
    1085                 1090                 1095             


Gly Leu  Tyr Tyr Asn Ile Glu  Leu Glu Leu Cys Asp  Trp Ala Gln 
    1100                 1105                 1110             


Asn Val  Asn Cys Glu Asn Arg  Asn Leu Pro Ser Leu  Asn Lys His 
    1115                 1120                 1125             


Trp Glu  Ser Arg Gln Thr Leu  Arg Lys 
    1130                 1135         


<210>  411
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  411

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Thr Ser Ile Ala Ser Ile Asn 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Val Asn Gly Ser Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Glu Asn Thr Val Pro Leu 
65                  70                  75                  80  


Leu Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Gly 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  412
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  412

Thr Ser Ile Ala Ser Ile Asn Ala 
1               5               


<210>  413
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  413

Ile Val Asn Gly Ser Thr Thr 
1               5           


<210>  414
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  414

Gly Ala Arg Asp Leu Ser Gly Thr Tyr 
1               5                   


<210>  415
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  415

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Thr Ser Ile Ala Ser Ile Asn 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Val Asn Gly Ser Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Gly 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  416
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  416

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Thr Ser Ile Ala Ser Ile Asn 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Val Asn Gly Ser Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Gly 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  417
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  417

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Ile Ser Thr Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Arg Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  418
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  418

Arg Gly Thr Phe Ser Arg Tyr Val 
1               5               


<210>  419
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  419

Ile Ser Trp Ser Gly Ile Ser Thr 
1               5               


<210>  420
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  420

Ala Ala Asp Pro Gly Arg Gly Tyr Asp Tyr 
1               5                   10  


<210>  421
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  421

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Arg Ser 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Ser Trp Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Val Gly Arg Gly Tyr His Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  422
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  422

Gly Arg Ser Phe Ser Arg Ser Val 
1               5               


<210>  423
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  423

Thr Ser Trp Ser Gly Gly Gly Thr 
1               5               


<210>  424
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  424

Ala Ala Asp Val Gly Arg Gly Tyr His Tyr 
1               5                   10  


<210>  425
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  425

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Thr Phe Ser Gly Leu 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gln Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Trp Ala Ser Gly Thr Pro Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  426
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  426

Gly Gly Thr Phe Ser Gly Leu Thr 
1               5               


<210>  427
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  427

Ile Ser Trp Thr Gly Arg Ser Thr 
1               5               


<210>  428
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  428

Ala Ala Asp Trp Ala Ser Gly Thr Pro Tyr 
1               5                   10  


<210>  429
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  429

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Gly Leu 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gln Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Val Ala Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Trp Ala Ser Ala Thr Pro Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  430
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  430

Ala Ala Asp Trp Ala Ser Ala Thr Pro Tyr 
1               5                   10  


<210>  431
<211>  149
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  431

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Glu 
1               5                   10                  15      


Ser Leu Thr Leu Ala Cys Val Ile Ser Gly Ile Thr Leu Glu Arg Tyr 
            20                  25                  30          


Thr Val Gly Trp Phe His Gln Ala Pro Gly Lys Asn Pro Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Gly Lys Ser Asn Asp Glu Thr Phe Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Pro Ser Asp Ala Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Lys Ala Pro Val Thr Ala Tyr Asp Cys Ser Leu Tyr Leu 
            100                 105                 110         


Tyr Thr Trp Arg Ser Thr Tyr Arg Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His 
    130                 135                 140                 


His His His His His 
145                 


<210>  432
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  432

Gly Ile Thr Leu Glu Arg Tyr Thr 
1               5               


<210>  433
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  433

Ile Gly Lys Ser Asn Asp Glu Thr 
1               5               


<210>  434
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  434

Ala Ala Ala Lys Ala Pro Val Thr Ala Tyr Asp Cys Ser Leu Tyr Leu 
1               5                   10                  15      


Tyr Thr Trp Arg Ser Thr Tyr 
            20              


<210>  435
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  435

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Ala Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Leu Ala Trp Phe Arg Gln Thr Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Ile Ser Arg Ser Gly Ser Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Gln Arg Ala Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Arg Ser Tyr Tyr Asn Ile Pro Tyr Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  436
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  436

Ala Arg Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  437
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  437

Ala Ala Gly Ser Arg Ser Tyr Tyr Asn Ile Pro Tyr Tyr Asp Tyr 
1               5                   10                  15  


<210>  438
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  438

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Trp Ser Gly Gly Ser Lys Tyr Tyr Arg Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Thr Ser Ala Arg Tyr Thr Ser Gly Ala Leu Tyr Tyr Arg Asp 
            100                 105                 110         


Arg Gln Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His 
    130                 135                 140                 


His His His 
145         


<210>  439
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  439

Val Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  440
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  440

Ile Thr Trp Ser Gly Gly Ser Lys 
1               5               


<210>  441
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  441

Ala Ala Thr Ser Ala Arg Tyr Thr Ser Gly Ala Leu Tyr Tyr Arg Asp 
1               5                   10                  15      


Arg Gln Tyr Asn Tyr 
            20      


<210>  442
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  442

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Arg Thr Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Arg Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Thr Asp Tyr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Ile Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Asp Arg Ser Thr Gly Trp Gln Pro Ser Thr Ser Arg Tyr Asp 
            100                 105                 110         


Tyr Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  443
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  443

Thr Arg Thr Phe Gly Asn Tyr Ala 
1               5               


<210>  444
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  444

Ile Asn Arg Arg Gly Thr Thr Thr 
1               5               


<210>  445
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  445

Ala Val Asp Arg Ser Thr Gly Trp Gln Pro Ser Thr Ser Arg Tyr Asp 
1               5                   10                  15      


Tyr Ala Ser 
            


<210>  446
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  446

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ser 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Tyr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Thr Ser Gly Gly Met Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe His Gly Asp Lys Gly Tyr Gly Ser Ser Trp Tyr Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  447
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  447

Gly Arg Thr Phe Arg Tyr His Ala 
1               5               


<210>  448
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  448

Ile Ser Thr Ser Gly Gly Met Thr 
1               5               


<210>  449
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  449

Ala Lys Phe His Gly Asp Lys Gly Tyr Gly Ser Ser Trp Tyr Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  450
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  450

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Ile 
        35                  40                  45              


Ser Ile Ile Asn Ser Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Asn Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Val Arg Arg Asn Trp Gly Leu Gly Thr His Ser Gly Glu Tyr Val 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  451
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  451

Ile Asn Ser Gly Gly Gly Ser Thr 
1               5               


<210>  452
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  452

Gly Val Arg Arg Asn Trp Gly Leu Gly Thr His Ser Gly Glu Tyr Val 
1               5                   10                  15      


Tyr 
    


<210>  453
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  453

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Val Arg Glu Gly Val 
        35                  40                  45              


Ser Thr Ile Lys Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Arg Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Arg Arg Trp Pro Tyr Asp Tyr Ile Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  454
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  454

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  455
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  455

Ile Lys Ser Ser Asp Gly Ser Thr 
1               5               


<210>  456
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  456

Ala Ala Gly Ala Arg Arg Trp Pro Tyr Asp Tyr Ile Tyr 
1               5                   10              


<210>  457
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  457

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Ile Phe Leu Asn Tyr 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Gly Ser Asn Ile Asp Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Ser Tyr Trp Lys Ile Arg Thr Thr Leu Asn Gly Leu 
            100                 105                 110         


Asp Lys Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  458
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  458

Glu Arg Ile Phe Leu Asn Tyr Asn 
1               5               


<210>  459
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  459

Ile Thr Trp Ser Gly Ser Asn Ile 
1               5               


<210>  460
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  460

Ala Ala Asp Pro Ser Tyr Trp Lys Ile Arg Thr Thr Leu Asn Gly Leu 
1               5                   10                  15      


Asp Lys 
        


<210>  461
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  461

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Phe 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Leu Ile Thr Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Asp Ser Thr Thr Ser Tyr Val Thr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  462
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  462

Gly Arg Thr Phe Ser Arg Phe Pro 
1               5               


<210>  463
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  463

Ile Ser Trp Ser Gly Gly Ser Thr 
1               5               


<210>  464
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  464

Ala Arg Arg Asp Ser Thr Thr Ser Tyr Val Thr 
1               5                   10      


<210>  465
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  465

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Gly Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gln Ile Ser Trp Ser Gly Gly Ile Thr Ala Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Arg Lys Tyr Glu Asp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Gly Ser His His His His His His 
    130                 135         


<210>  466
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  466

Gly Gly Thr Phe Thr Thr Tyr Thr 
1               5               


<210>  467
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  467

Ile Ser Trp Ser Gly Gly Ile Thr 
1               5               


<210>  468
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  468

Ala Arg Arg Gly Arg Lys Tyr Glu Asp Asp Tyr 
1               5                   10      


<210>  469
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  469

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Val Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Trp Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Gln Gly Tyr Lys Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Gly Ser His His His His His His 
    130                 135     


<210>  470
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  470

Gly Arg Thr Phe Ser Ser Tyr Ile 
1               5               


<210>  471
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  471

Ile Ser Trp Ser Gly Gly Phe Thr 
1               5               


<210>  472
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  472

Ala Ala Asp Pro Gly Gln Gly Tyr Lys Tyr 
1               5                   10  


<210>  473
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  473

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ser Phe Arg Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Met Ser Gly Val Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Asp Arg Thr Gly Lys Ala Asp Tyr Ser Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  474
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  474

Gly Arg Ser Phe Arg Ser Tyr Thr 
1               5               


<210>  475
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  475

Ile Ser Met Ser Gly Val Val Thr 
1               5               


<210>  476
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  476

Ala Ala Arg Pro Asp Arg Thr Gly Lys Ala Asp Tyr 
1               5                   10          


<210>  477
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  477

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Arg Ser 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Ser Leu Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Lys Leu Gly Gly Thr Trp Asp Ser Trp Gly Pro Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Gly Ser His His His His His His 
    130                 135         


<210>  478
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  478

Gly Gly Thr Phe Ser Arg Ser Ile 
1               5               


<210>  479
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  479

Ile Ser Trp Ser Gly Ser Leu Thr 
1               5               


<210>  480
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  480

Ala Ala Asp Lys Leu Gly Gly Thr Trp Asp Ser 
1               5                   10      


<210>  481
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  481

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Ala Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Val Ser Arg Phe Gly Lys Phe Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Asp Gly Ser Ser Trp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  482
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  482

Gly Arg Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  483
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  483

Ala Lys Thr Asp Gly Ser Ser Trp Tyr Leu Asp Tyr 
1               5                   10          


<210>  484
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  484

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Asn Thr Tyr Phe Gly Asp Ser Ala 
    50                  55                  60                  


Glu Ala Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Val Ala Gly Ser Thr Ser Arg Tyr Thr Tyr Asp 
            100                 105                 110         


Gln Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  485
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  485

Gly Arg Thr Phe Ser Ser Tyr Val 
1               5               


<210>  486
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  486

Ile Ser Arg Ser Gly Gly Asn Thr 
1               5               


<210>  487
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  487

Ala Arg Tyr Arg Leu Val Ala Gly Ser Thr Ser Arg Tyr Thr Tyr Asp 
1               5                   10                  15      


Gln 
    


<210>  488
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  488

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala His Ser Gly Arg Pro Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Gly Gly Leu Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Leu Arg Asp Arg Pro Thr Lys Asp Glu Tyr Val Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  489
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  489

Gly Arg Pro Phe Ser Ser Ser Ala 
1               5               


<210>  490
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  490

Ile Ser Arg Gly Gly Leu Ser Lys 
1               5               


<210>  491
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  491

Ala Gly Ser Leu Arg Asp Arg Pro Thr Lys Asp Glu Tyr Val Val 
1               5                   10                  15  


<210>  492
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  492

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Arg Ser Arg Tyr Ala Leu 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Phe Val Gly Ala 
        35                  40                  45              


Ala Arg Gly Gly Ala Gly Asn Thr Tyr Tyr His Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Leu Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala 
                85                  90                  95      


Gly Lys Asp Phe Gly Thr Ala Val Ser Trp Thr Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  493
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  493

Gly Arg Ser Arg Tyr Ala 
1               5       


<210>  494
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  494

Ala Arg Gly Gly Ala Gly Asn Thr 
1               5               


<210>  495
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  495

Ala Ala Gly Lys Asp Phe Gly Thr Ala Val Ser Trp Thr Ser 
1               5                   10                  


<210>  496
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  496

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Gly Leu 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Arg Phe Thr Tyr Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Asp Val Leu Ser Gly Arg Gly Tyr Arg Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  497
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  497

Ile Ser Trp Asn Gly Arg Phe Thr 
1               5               


<210>  498
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  498

Gly Ala Asp Val Leu Ser Gly Arg Gly Tyr Arg Tyr 
1               5                   10          


<210>  499
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  499

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Ala Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Arg Lys Glu Arg Glu Phe Ile 
        35                  40                  45              


Thr Ala Ile Asn Arg Asn Gly Asp Arg Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Thr Glu Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


His Thr Arg Arg Phe Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly 
        115                 120                 125             


Ser His His His His His His 
    130                 135 


<210>  500
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  500

Gly Arg Ala Phe Ser Thr Tyr Gly 
1               5               


<210>  501
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  501

Ile Asn Arg Asn Gly Asp Arg Thr 
1               5               


<210>  502
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  502

His Thr Arg Arg Phe Gly Tyr Asp Tyr 
1               5                   


<210>  503
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  503

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ile Ser Gly Leu Ser Arg Tyr Tyr Ala 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Ser Val Ala 
        35                  40                  45              


Thr Ile Ser Leu Arg Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Ala Asp Thr Thr Trp Gly Ala Pro Arg Ser Arg Tyr His Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp 
        115                 120                 125             


Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140 


<210>  504
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  504

Gly Leu Ser Arg Tyr Tyr Ala 
1               5           


<210>  505
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  505

Ile Ser Leu Arg Gly Gly Arg Thr 
1               5               


<210>  506
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  506

Val Ala Asp Thr Thr Trp Gly Ala Pro Arg Ser Arg Tyr His Tyr 
1               5                   10                  15  


<210>  507
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  507

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Met Gly Ser Ser Ser Arg Gly Asn Arg Tyr Leu Glu Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  508
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  508

Ala Lys Met Gly Ser Ser Ser Arg Gly Asn Arg Tyr Leu Glu Val 
1               5                   10                  15  


<210>  509
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  509

Ile Asn Ser Gly Gly Gly Ser Thr 
1               5               


<210>  510
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  510

Ala Lys Met Gly Ser Ser Ser Arg Gly Asn Arg Tyr Leu Glu Val 
1               5                   10                  15  


<210>  511
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  511

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Ala Arg Thr Phe Ile Ala Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly Met Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Pro Ala Arg Arg Ser Tyr Ser Tyr Arg Asp Gly Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  512
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  512

Ala Arg Thr Phe Ile Ala Tyr Ala 
1               5               


<210>  513
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  513

Ile Ser Trp Asn Gly Gly Met Thr 
1               5               


<210>  514
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  514

Thr Ala Gly Pro Ala Arg Arg Ser Tyr Ser Tyr Arg Asp Gly Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  515
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  515

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Ala Arg Thr Phe Ile Ala Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly Met Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Ser Ala Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Pro Ala Arg Arg Ser Tyr Ser Tyr Arg Asp Gly Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  516
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  516

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Val Ala Ser Gly Arg Thr Gly Ser Tyr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly Met Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Pro Ala Arg Arg Ser Tyr Ser Tyr Arg Asp Gly Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  517
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  517

Gly Arg Thr Gly Ser Tyr Tyr Ala 
1               5               


<210>  518
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  518

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Ala Arg Thr Phe Ile Ala Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly Met Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Pro Ala Arg Arg Ser Tyr Ser Tyr Arg Asp Gly Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  519
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  519

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Ala Arg Thr Phe Ile Ala Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly Met Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Pro Ala Arg Arg Ser Tyr Ser Tyr Arg Asp Gly Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  520
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  520

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Asp Lys Gln Arg Glu Phe Leu 
        35                  40                  45              


Ala Val Ile Thr Pro Arg Gly Arg Thr Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Met Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Gly Arg Tyr Arg Ser Tyr Asp Ala Arg Phe Ala Thr Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  521
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  521

Gly Ser Ile Phe Ser Thr Asn Ala 
1               5               


<210>  522
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  522

Ile Thr Pro Arg Gly Arg Thr 
1               5           


<210>  523
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  523

Tyr Ala Gly Arg Tyr Arg Ser Tyr Asp Ala Arg Phe Ala Thr Asp Ile 
1               5                   10                  15      


<210>  524
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  524

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Asp Lys Gln Arg Glu Phe Leu 
        35                  40                  45              


Ala Val Ile Thr Pro Arg Gly Arg Thr Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Met Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Gly Arg Tyr Arg Ser Tyr Asp Ala Arg Phe Ala Thr Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  525
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  525

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Asp Lys Gln Arg Glu Phe Leu 
        35                  40                  45              


Ala Val Ile Thr Pro Arg Gly Arg Thr Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Met Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Gly Arg Tyr Arg Ser Phe Asp Ala Arg Phe Ala Thr Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  526
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  526

Tyr Ala Gly Arg Tyr Arg Ser Phe Asp Ala Arg Phe Ala Thr Asp Ile 
1               5                   10                  15      


<210>  527
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  527

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Asp Lys Gln Arg Glu Phe Leu 
        35                  40                  45              


Ala Val Ile Thr Pro Arg Gly Arg Thr Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Met Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Gly Arg Tyr Arg Ser Phe Asp Ala Arg Phe Ala Thr Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  528
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  528

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Asp Lys Gln Arg Glu Phe Leu 
        35                  40                  45              


Ala Val Ile Thr Pro Arg Gly Arg Thr Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Met Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Gly Arg Tyr Arg Ser Phe Asp Ala Arg Phe Ala Thr Asp Ile Trp 
            100                 105                 110         


Ser Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  529
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  529

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Asp Lys Gln Arg Glu Phe Leu 
        35                  40                  45              


Ala Val Ile Thr Pro Arg Gly Arg Thr Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Val Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Gly Arg Tyr Arg Ser Phe Asp Ala Arg Phe Ala Thr Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr 
        115                 120                 125             


Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140     


<210>  530
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  530

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Phe Leu Thr Gly Ala 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Thr Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Tyr Thr Lys Arg Ala Leu Ile Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Ile Arg Gly Phe Tyr Arg Gln Thr Gln Phe Arg Glu Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  531
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  531

Gly Ala Phe Leu Thr Gly Ala Thr 
1               5               


<210>  532
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  532

Ile Ile Thr Gly Gly Thr Thr 
1               5           


<210>  533
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  533

Ser Ile Arg Gly Phe Tyr Arg Gln Thr Gln Phe Arg Glu Ile 
1               5                   10                  


<210>  534
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  534

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Phe Leu Thr Gly Ala 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Thr Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Tyr Thr Lys Arg Ala Leu Ile Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Ile Arg Gly Phe Tyr Arg Gln Thr Gln Phe Arg Glu Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  535
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  535

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Phe Leu Thr Gly Ala 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Thr Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Tyr Thr Lys Arg Ala Leu Ile Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Ile Arg Gly Phe Tyr Arg Gln Thr Gln Phe Arg Glu Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  536
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  536

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Glu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Phe Leu Thr Gly Ala 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Thr Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Tyr Thr Lys Arg Ala Leu Ile Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Ile Arg Gly Phe Tyr Arg Gln Thr Gln Phe Arg Glu Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  537
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  537

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Glu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Phe Leu Thr Gly Ala 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Thr Pro Gly Asn Leu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Thr Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Tyr Thr Lys Arg Ala Leu Ile Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Ile Arg Gly Phe Tyr Arg Gln Thr Gln Phe Arg Glu Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 


<210>  538
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  538

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Asn Arg Ser Ser Thr Arg Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Val Ser Ile Leu Gly Lys Gly Tyr Arg Asp Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  539
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  539

Gly Arg Thr Phe Ser Asn Tyr Val 
1               5               


<210>  540
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  540

Ile Asn Arg Ser Ser Thr Arg Leu 
1               5               


<210>  541
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  541

Ala Ala Asp Leu Val Ser Ile Leu Gly Lys Gly Tyr Arg Asp Val Asp 
1               5                   10                  15      


Tyr 
    


<210>  542
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  542

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Asn Arg Ser Ser Thr Arg Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Val Ser Ile Leu Gly Lys Gly Tyr Arg Asp Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  543
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  543

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Asn Arg Ser Ser Thr Arg Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Val Ser Ile Leu Gly Lys Gly Tyr Arg Asp Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  544
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  544

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Asn Arg Ser Ser Thr Arg Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Val Ser Ile Leu Gly Lys Gly Tyr Arg Asp Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140             


<210>  545
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  545

Gly Phe Ser Phe Ser Asn Tyr Val 
1               5               


<210>  546
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  546

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Gly Ala Gly Val Lys Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Arg Pro Ile Ser Gly Ser Tyr Ser Asn Glu Arg Asp Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  547
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  547

Gly Arg Thr Phe Ser Pro Tyr Thr 
1               5               


<210>  548
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  548

Ile Ser Trp Gly Ala Gly Val Lys 
1               5               


<210>  549
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  549

Ala Ala Lys Arg Pro Ile Ser Gly Ser Tyr Ser Asn Glu Arg Asp Tyr 
1               5                   10                  15      


Ala Tyr 
        


<210>  550
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  550

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Gly Ala Gly Val Lys Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Arg Pro Ile Ser Gly Ser Tyr Ser Asn Glu Arg Asp Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  551
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  551

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Thr Asn Phe Leu Ser Ser Arg Phe 
            20                  25                  30          


Glu Met Gly Trp Tyr Arg Gln Ile Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Phe Arg Asp Gly Asn Thr Asp Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Ile Asp Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Gly Tyr Phe Cys His 
                85                  90                  95      


Val His Ile Leu Gly Arg Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  552
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  552

Asn Phe Leu Ser Ser Arg Phe Glu 
1               5               


<210>  553
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  553

Ile Phe Arg Asp Gly Asn Thr 
1               5           


<210>  554
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  554

His Val His Ile Leu Gly Arg Asp Tyr 
1               5                   


<210>  555
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  555

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Thr Thr Met Gly Leu Pro Val Gly Gly Thr Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  556
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  556

Gly Arg Thr Phe Ser Ser Tyr Pro 
1               5               


<210>  557
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  557

Ile Ser Arg Ser Gly Gly Arg Thr 
1               5               


<210>  558
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  558

Ala Ala Lys Thr Thr Met Gly Leu Pro Val Gly Gly Thr Tyr Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  559
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  559

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Thr Thr Met Gly Leu Pro Val Gly Gly Thr Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  560
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  560

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asn Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Ser Met Val Phe 
65                  70                  75                  80  


Leu Arg Met Asn Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gln Asn Phe Trp Thr Phe Thr Thr Thr Pro Pro Pro Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  561
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  561

Gly Phe Thr Leu Asp Asp Tyr Ala 
1               5               


<210>  562
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  562

Ile Asp Ser Asn Gly Ser Asn Thr 
1               5               


<210>  563
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  563

Ala Ala Gly Gln Asn Phe Trp Thr Phe Thr Thr Thr Pro Pro Pro Tyr 
1               5                   10                  15      


<210>  564
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  564

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Pro Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Phe Gly Asn Leu Gly Gly Gly Val Gly Arg Ser Ser Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His 
    130                 135                 140                 


His 
145 


<210>  565
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  565

Gly Arg Thr Phe Ser Asn Tyr Pro 
1               5               


<210>  566
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  566

Ile Ser Arg Ser Gly Gly Gly Thr 
1               5               


<210>  567
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  567

Ala Ala Tyr Phe Gly Asn Leu Gly Gly Gly Val Gly Arg Ser Ser Asp 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  568
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  568

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Asn Val Leu Val Ser Lys Phe 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ala Arg Ala Gly Phe Thr Ser Tyr Ala Asp Phe Val Arg 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Cys His Val Leu Gly Arg Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  569
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  569

Asn Val Leu Val Ser Lys Phe Thr 
1               5               


<210>  570
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  570

Ile Ala Arg Ala Gly Phe Thr 
1               5           


<210>  571
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  571

Asn Cys His Val Leu Gly Arg Asp Tyr 
1               5                   


<210>  572
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  572

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ile Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Phe Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Gly Ser Arg Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Gly Arg Thr Asn Ile Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  573
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  573

Ile Arg Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  574
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  574

Ile Ser Ser Gly Ser Arg Thr 
1               5           


<210>  575
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  575

Thr Lys Gly Arg Thr Asn Ile Asp Tyr 
1               5                   


<210>  576
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  576

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Met Ala Thr Gly Thr Ala Ser Ile Arg Thr Tyr Glu Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140                 


<210>  577
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  577

Ile Ser Thr Gly Gly Gly Thr Thr 
1               5               


<210>  578
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  578

Ala Ala Lys Met Ala Thr Gly Thr Ala Ser Ile Arg Thr Tyr Glu Tyr 
1               5                   10                  15      


Ala Tyr 
        


<210>  579
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  579

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Leu Trp Gly Gly Val Ile Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met 
65                  70                  75                  80  


Phe Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg 
                85                  90                  95      


Arg Gly Gly Leu Asn Asn His Leu Gly Ser Val Gly Asn Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
        115                 120                 125             


Tyr Asp Val Pro Asp Tyr Gly Ser His His His His His His 
    130                 135                 140         


<210>  580
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  580

Gly Phe Thr Phe Ser Arg Tyr Ala 
1               5               


<210>  581
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  581

Ile Leu Trp Gly Gly Val 
1               5       


<210>  582
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  582

Ala Arg Arg Arg Gly Gly Leu Asn Asn His Leu Gly Ser Val Gly Asn 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  583
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  583

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ile Ile Gly Ala Thr Val Ser Ser Ser 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Gln Ala Pro Gly Leu Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Thr Pro Ser Asn Pro His Tyr Ala Ala Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Arg Asn Leu Asn Tyr Leu 
65                  70                  75                  80  


Gln Ile Asp Ser Ala Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Ala Ile Arg Gly Ser Ile Tyr Arg Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
        115                 120                 125             


His His His His His His 
    130                 


<210>  584
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  584

Gly Ala Thr Val Ser Ser Ser Ser 
1               5               


<210>  585
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  585

Ile Thr Thr Pro Ser Asn Pro 
1               5           


<210>  586
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  586

His Ala Ala Ile Arg Gly Ser Ile Tyr 
1               5                   


<210>  587
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  587

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Arg Ala Phe Thr Asn Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Ser Trp Ser Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Ala 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  588
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  588

Gly Arg Ala Phe Thr Asn Tyr His 
1               5               


<210>  589
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  589

Ile Ser Trp Ser Gly Asp Ser Thr 
1               5               


<210>  590
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  590

Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Val 
1               5                   10          


<210>  591
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  591

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Thr Asn Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Ser Trp Ser Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Ala 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  592
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  592

Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Ile 
1               5                   10          


<210>  593
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  593

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Thr Asn Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Ser Trp Ser Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Ala 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  594
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  594

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Arg Ala Phe Thr Asn Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Ser Trp Ser Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Ala 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


<210>  595
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Complementarity-determining region amino acid sequence

<400>  595

Thr Arg Ala Phe Thr Asn Tyr His 
1               5               


<210>  596
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nanobody amino acid sequence

<400>  596

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Thr Asn Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Ser Trp Ser Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Ala 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Leu Val Gly Gln Ser Gln Tyr Glu Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
        115                 120                 125             


Asp Tyr Gly Ser His His His His His His 
    130                 135             


