                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Anti-ROR-2 Antibodies and Methods of Use

<130>  048537-632001WO

<150>  US 62/936,900
<151>  2019-11-18

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aattatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cactcactat      180

gtagacagtg tgaaggggcg attcaccatt tccagagaca atgccaacca tatcctgtac      240

ctgcaaatga gcagtctgaa ctctgaggac acagccatgt attattgtgc aagacacccg      300

agggattttt cctatgctat ggactactgg ggtcagggaa cctcagtcac cgtctcctca      360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr His Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn His Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Asn Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Pro Arg Asp Phe Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt cattatgtgg cctggtatca acagaaacca      120

ggtcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gtagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tataacatct atccgtggac gttcggtgga      300

ggctccaagc tggcaatcaa a                                                321


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly His Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ser Lys Leu Ala Ile Lys 
            100                 105         


<210>  5
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
caggttcaac tgcaacagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg ctttgggcta cacatttact gactatgaaa tgcactgggt gaagcagaca      120

cctgtgcatg gcctggaatg gattggagct attcatccag gaagtggtgg tactgcctat      180

aatcagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atggagctca gcaggctgac atctgaggac tctgctgtct attactgtac aagaaggagg      300

cctaggttct atggtatgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Arg Pro Arg Phe Tyr Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcct      300

ctcacggtcg gtgctgggac caagctggag ctgaaa                                336


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Val Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  9
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gaggtgcagc tggtggagtc tgggggagac ttggtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggttc cacctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa ctccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatccc      300

tatgattacg ggtactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  10
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Pro Tyr Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gacatcttgc tgactcagtc tccagacatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcagagaaca      120

aatggttctc caaggcttct cataaaatat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtgatagct ggccattccc gttcggctcg      300

gggacaaaat tggaaaaaaa a                                                321


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Asp Ile Leu Leu Thr Gln Ser Pro Asp Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Phe 
                85                  90                  95      


Pro Phe Gly Ser Gly Thr Lys Leu Glu Lys Lys 
            100                 105         


<210>  13
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaagctc       60

tcatgtgcag cctctggatt caccttcaat acctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctccatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

cacggtagta gcctctacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu His Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Ser Ser Leu Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt ggttacttag gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa      180

aggttcagtg gcagtaggtc tgggtcagct tattctctca ccatcagcag ccttgagtct      240

gaagattttg cagactatta ctgtctacaa tatgctagtt atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Ala Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
atggcccggg gctcggcgct cccgcggcgg ccgctgctgt gcatcccggc cgtctgggcg       60

gccgccgcgc ttctgctctc agtgtcccgg acttcaggtg aagtggaggt tctggatccg      120

aacgaccctt taggacccct tgatgggcag gacggcccga ttccaactct gaaaggttac      180

tttctgaatt ttctggagcc agtaaacaat atcaccattg tccaaggcca gacggcaatt      240

ctgcactgca aggtggcagg aaacccaccc cctaacgtgc ggtggctaaa gaatgatgcc      300

ccggtggtgc aggagccgcg gcggatcatc atccggaaga cagaatatgg ttcacgactg      360

cgaatccagg acctggacac gacagacact ggctactacc agtgcgtggc caccaacggg      420

atgaagacca ttaccgccac tggcgtcctg tttgtgcggc tgggtccaac gcacagccca      480

aatcataact ttcaggatga ttaccacgag gatgggttct gccagcctta ccggggaatt      540

gcctgtgcac gcttcattgg caaccggacc atttatgtgg actcgcttca gatgcagggg      600

gagattgaaa accgaatcac agcggccttc accatgatcg gcacgtctac gcacctgtcg      660

gaccagtgct cacagttcgc catcccatcc ttctgccact tcgtgtttcc tctgtgcgac      720

gcgcgctccc gggcacccaa gccgcgtgag ctgtgccgcg acgagtgcga ggtgctggag      780

agcgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

cttcagctgc ccaagtgtga ggcgctgccc atgcctgaga gccccgacgc tgccaactgc      900

atgcgcattg gcatcccagc cgagaggctg ggccgctacc atcagtgcta taacggctca      960

ggcatggatt acagaggaac ggcaagcacc accaagtcag gccaccagtg ccagccgtgg     1020

gccctgcagc acccccacag ccaccacctg tccagcacag acttccctga gcttggaggg     1080

gggcacgcct actgccggaa ccccggaggc cagatggagg gcccctggtg ctttacgcag     1140

aataaaaacg tacgcatgga actgtgtgac gtaccctcgt gtagtccccg agacagcagc     1200

aagatgggga ttctgtacat cttggtcccc agcatcgcaa ttccactggt catcgcttgc     1260

cttttcttct tggtttgcat gtgccggaat aagcagaagg catctgcgtc cacaccgcag     1320

cggcgacagc tgatggcctc gcccagccaa gacatggaaa tgcccctcat taaccagcac     1380

aaacaggcca aactcaaaga gatcagcctg tctgcggtga ggttcatgga ggagctggga     1440

gaggaccggt ttgggaaagt ctacaaaggt cacctgttcg gccctgcccc gggggagcag     1500

acccaggctg tggccatcaa aacgctgaag gacaaagcgg aggggcccct gcgggaggag     1560

ttccggcatg aggctatgct gcgagcacgg ctgcaacacc ccaacgtcgt ctgcctgctg     1620

ggcgtggtga ccaaggacca gcccctgagc atgatcttca gctactgttc gcacggcgac     1680

ctccacgaat tcctggtcat gcgctcgccg cactcggacg tgggcagcac cgatgatgac     1740

cgcacggtga agtccgccct ggagcccccc gacttcgtgc accttgtggc acagatcgcg     1800

gcggggatgg agtacctatc cagccaccac gtggttcaca aggacctggc cacccgcaat     1860

gtgctagtgt acgacaagct gaacgtgaag atctcagact tgggcctctt ccgagaggtg     1920

tatgccgccg attactacaa gctgctgggg aactcgctgc tgcctatccg ctggatggcc     1980

ccagaggcca tcatgtacgg caagttctcc atcgactcag acatctggtc ctacggtgtg     2040

gtcctgtggg aggtcttcag ctacggcctg cagccctact gcgggtactc caaccaggat     2100

gtggtggaga tgatccggaa ccggcaggtg ctgccttgcc ccgatgactg tcccgcctgg     2160

gtgtatgccc tcatgatcga gtgctggaac gagttcccca gccggcggcc ccgcttcaag     2220

gacatccaca gccggctccg agcctggggc aacctttcca actacaacag ctcggcgcag     2280

acctcggggg ccagcaacac cacgcagacc agctccctga gcaccagccc agtgagcaat     2340

gtgagcaacg cccgctacgt ggggcccaag cagaaggccc cgcccttccc acagccccag     2400

ttcatcccca tgaagggcca gatcagaccc atggtgcccc cgccgcagct ctacgtcccc     2460

gtcaacggct accagccggt gccggcctat ggggcctacc tgcccaactt ctacccggtg     2520

cagatcccaa tgcagatggc cccgcagcag gtgcctcctc agatggtccc caagcccagc     2580

tcacaccaca gtggcagtgg ctccaccagc acaggctacg tcaccacggc cccctccaac     2640

acatccatgg cagacagggc agccctgctc tcagagggcg ctgatgacac acagaacgcc     2700

ccagaagatg gggcccagag caccgtgcag gaagcagagg aggaggagga aggctctgtc     2760

ccagagactg agctgctggg ggactgtgac actctgcagg tggacgaggc ccaagtccag     2820

ctggaagctt ga                                                         2832


<210>  18
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  19
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
atggctcggg gctgggtgcg gccgagccgt gtgcctctgt gcgcccgggc cgtctggacg       60

gctgcggcgc tcctgctctg gacaccctgg acggcaggtg aagtggaaga ttcggaggca      120

atcgacacct tgggacaacc tgatggaccg gacagcccac ttcccactct gaaaggctac      180

tttctgaatt ttctggagcc agtcaacaat atcaccattg ttcagggcca gacggcaatc      240

ctgcactgca aggtggcggg aaacccacct cccaatgtgc ggtggctgaa gaatgatgcc      300

ccggttgtgc aagagccacg aagggtcgtc atccggaaga cagaatacgg ctcccggctg      360

cggatccaag acctggacac aacagacaca ggctactacc agtgtgtggc taccaacggg      420

ctgaagacca tcactgccac tggggttcta tatgtgcggc tcggtccgac gcacagcccg      480

aaccacaatt ttcaggatga cgatcaggaa gatggcttct gccagccgta ccgagggatc      540

gcttgtgcgc gcttcattgg gaaccggact atttatgtgg actccctcca gatgcagggg      600

gagattgaaa accgaatcac agctgccttc accatgatcg gcacctccac gcaactgtca      660

gaccagtgtt cacagtttgc catcccatcc ttctgccact tcgtcttccc tctgtgcgac      720

gcatgctccc gggcgcccaa gcctcgcgaa ctgtgccggg atgaatgtga ggtgctggag      780

aacgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

ctccagctgc ccaagtgcga agcgctgccc atgcccgaga gcccggatgc tgcgaactgc      900

atgcgcatcg ggatccccgc ggagaggctg ggtcgctacc accagtgcta caacggctcc      960

ggcgccgatt acagggggat ggccagtacc accaagtcag gccaccagtg tcagccttgg     1020

gctctgcagc acccccacag ccatcgccta tccagcacgg aattccctga gctgggagga     1080

ggccatgcct actgccggaa ccccgggggc cagatggaag gcccgtggtg ctttacgcag     1140

aataaaaacg tacgcgtgga actgtgtgac gtacccccgt gtagtccccg atatggcagc     1200

aagatgggga ttctgtacat cctggtcccc agcattgcta tccccctggt catcgcttgc     1260

ctgttcttcc tcgtctgcat gtgccgcaac aaacagaagg cttcggcctc caccccacag     1320

cgccggcagc tgatggcctc tcccagccag gacatggaga tgccactcat cagccagcac     1380

aaacaggcca aactcaaaga gatcagcttg tccacagtga ggttcatgga ggagctcggg     1440

gaggaccggt ttggcaaggt ctacaaaggc cacctgttcg ggcctgcccc aggagaacca     1500

acccaggccg tggccatcaa gacgctgaaa gacaaggctg aggggcccct gcgggaggag     1560

ttccggcaag aggcgatgct ccgggcccga ctgcagcacc ccaacatcgt ctgtctccta     1620

ggcgtcgtga ccaaggacca acccttgagc atgatcttca gctactgttc ccatggcgac     1680

cttcatgaat tcctggtcat gcgctcgccg cactccgatg tgggcagcac cgatgacgac     1740

cgcacagtga agtcagccct ggagcccccg gacttcgtgc acgtggtggc gcagatcgct     1800

gcggggatgg agttcctgtc cagccaccac gtgtgccata aggacctggc cacacgcaat     1860

gtgctggtgt acgacaagct gaacgtgagg atctcagact tgggcctctt ccgtgaggta     1920

tactccgcag attactacaa actcatgggc aattcactgc tgcccatccg ctggatgtcc     1980

cccgaggccg tcatgtatgg aaagttctcc atcgactctg acatctggtc ctacggtgtg     2040

gtcctctggg aggtctttag ctacggcctg cagccctact gtgggtactc caaccaggac     2100

gtggtggaga tgatccggag ccggcaggtg ctgccctgcc cggatgactg ccccgcctgg     2160

gtctatgccc tcatgattga atgctggaat gagttcccaa gccggaggcc ccgctttaag     2220

gacatccaca gccggctccg gtcctggggc aacctatcca actataatag ttccgcgcag     2280

acctcaggag ccagcaacac cacacagacc agctccctga gcaccagccc cgtaagcaat     2340

gtgagcaatg cccgctatat ggcccccaag cagaaggccc agcccttccc acagcctcag     2400

ttcatcccca tgaagggtca gatcagaccc ttggtgcccc ccgcacagct gtacatcccg     2460

gtgaacggct atcagccggt accggcatac ggggcctacc tgcccaactt ctacccagtc     2520

cagatcccca tgcagatggc cccacagcag gtgccccctc agatggtccc caagccgagc     2580

tcacaccaca gtggcagcgg ctccaccagc actggctacg tcaccacggc gccctccaat     2640

acatctgtgg cggacagggc ggccctactc tctgagggca ccgaggatgt acagaacatc     2700

gcggaagacg tggcccagag ccctgtgcag gaagcagagg aggaggagga ggggtctgtc     2760

cctgagactg aactcctggg agacaatgac acgctccagg tgaccgaggc ggctcatgtc     2820

cagcttgaag cctga                                                      2835


<210>  20
<211>  944
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Arg Gly Trp Val Arg Pro Ser Arg Val Pro Leu Cys Ala Arg 
1               5                   10                  15      


Ala Val Trp Thr Ala Ala Ala Leu Leu Leu Trp Thr Pro Trp Thr Ala 
            20                  25                  30          


Gly Glu Val Glu Asp Ser Glu Ala Ile Asp Thr Leu Gly Gln Pro Asp 
        35                  40                  45              


Gly Pro Asp Ser Pro Leu Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Val Val Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Leu Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Tyr Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Asp Gln Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr Gln Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Cys Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Asn Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Ala Asp Tyr Arg Gly Met Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His Arg Leu Ser Ser 
            340                 345                 350         


Thr Glu Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Val Glu Leu Cys Asp Val Pro Pro Cys Ser Pro Arg Tyr Gly Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Ser Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Thr Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Pro Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg Gln Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Ile Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Val Val Ala Gln Ile Ala Ala Gly Met Glu Phe Leu Ser Ser 
        595                 600                 605             


His His Val Cys His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Arg Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Lys Leu Met Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ser Pro Glu Ala Val Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Ser Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ser Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Met Ala Pro Lys Gln Lys Ala Gln Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Leu Val Pro Pro Ala Gln 
                805                 810                 815     


Leu Tyr Ile Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Val Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Thr Glu Asp 
                885                 890                 895     


Val Gln Asn Ile Ala Glu Asp Val Ala Gln Ser Pro Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Asn Asp Thr Leu Gln Val Thr Glu Ala Ala His Val Gln Leu Glu Ala 
    930                 935                 940                 


<210>  21
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
atggcccggg gctcggcgct cccgcggcgg ccgctgctgt gcatcccggc cgtctgggcg       60

gccgccgcgc ttctgctctc agtgtcccgg acttcaggtg aagtggaggt tctggatccg      120

aacgaccctt taggacccct tgatgggcag gacggcccga ttccaactct gaaaggttac      180

tttctgaatt ttctggagcc agtaaacaat atcaccattg tccaaggcca gacggcaatt      240

ctgcactgca aggtggcagg aaacccaccc cctaacgtgc ggtggctaaa gaatgatgcc      300

ccggtggtgc aggagccgcg gcggatcatc atccggaaga cagaatatgg ttcacgactg      360

cgaatccagg acctggacac gacagacact ggctactacc agtgcgtggc caccaacggg      420

atgaagacca ttaccgccac tggcgtcctg tttgtgcggc tgggtccaac gcacagccca      480

aatcataact ttcaggatga ttaccacgag gatgggttct gccagcctta ccggggaatt      540

gcctgtgcac gcttcattgg caaccggacc atttatgtgg actcgcttca gatgcagggg      600

gagattgaaa accgaatcac agcggccttc accatgatcg gcacgtctac gcacctgtcg      660

gaccagtgct cacagttcgc catcccatcc ttctgccact tcgtgtttcc tctgtgcgac      720

gcgcgctccc gggcacccaa gccgcgtgag ctgtgccgcg acgagtgcga ggtgctggag      780

agcgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

cttcagctgc ccaagtgtga ggcgctgccc atgcctgaga gccccgacgc tgccaactgc      900

atgcgcattg gcatcccagc cgagaggctg ggccgctacc atcagtgcta taacggctca      960

ggcatggatt acagaggaac ggcaagcacc accaagtcag gccaccagtg ccagccgtgg     1020

gccctgcagc acccccacag ccaccacctg tccagcacag acttccctga gcttggaggg     1080

gggcacgcct actgccggaa ccccggaggc cagatggagg gcccctggtg ctttacgcag     1140

aataaaaacg tacgcatgga actgtgtgac gtaccctcgt gtagtccccg agacagcagc     1200

aagatgggg                                                             1209


<210>  22
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly 
            


<210>  23
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
atggctcggg gctgggtgcg gccgagccgt gtgcctctgt gcgcccgggc cgtctggacg       60

gctgcggcgc tcctgctctg gacaccctgg acggcaggtg aagtggaaga ttcggaggca      120

atcgacacct tgggacaacc tgatggaccg gacagcccac ttcccactct gaaaggctac      180

tttctgaatt ttctggagcc agtcaacaat atcaccattg ttcagggcca gacggcaatc      240

ctgcactgca aggtggcggg aaacccacct cccaatgtgc ggtggctgaa gaatgatgcc      300

ccggttgtgc aagagccacg aagggtcgtc atccggaaga cagaatacgg ctcccggctg      360

cggatccaag acctggacac aacagacaca ggctactacc agtgtgtggc taccaacggg      420

ctgaagacca tcactgccac tggggttcta tatgtgcggc tcggtccgac gcacagcccg      480

aaccacaatt ttcaggatga cgatcaggaa gatggcttct gccagccgta ccgagggatc      540

gcttgtgcgc gcttcattgg gaaccggact atttatgtgg actccctcca gatgcagggg      600

gagattgaaa accgaatcac agctgccttc accatgatcg gcacctccac gcaactgtca      660

gaccagtgtt cacagtttgc catcccatcc ttctgccact tcgtcttccc tctgtgcgac      720

gcatgctccc gggcgcccaa gcctcgcgaa ctgtgccggg atgaatgtga ggtgctggag      780

aacgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

ctccagctgc ccaagtgcga agcgctgccc atgcccgaga gcccggatgc tgcgaactgc      900

atgcgcatcg ggatccccgc ggagaggctg ggtcgctacc accagtgcta caacggctcc      960

ggcgccgatt acagggggat ggccagtacc accaagtcag gccaccagtg tcagccttgg     1020

gctctgcagc acccccacag ccatcgccta tccagcacgg aattccctga gctgggagga     1080

ggccatgcct actgccggaa ccccgggggc cagatggaag gcccgtggtg ctttacgcag     1140

aataaaaacg tacgcgtgga actgtgtgac gtacccccgt gtagtccccg atatggcagc     1200

aagatgggg                                                             1209


<210>  24
<211>  403
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Arg Gly Trp Val Arg Pro Ser Arg Val Pro Leu Cys Ala Arg 
1               5                   10                  15      


Ala Val Trp Thr Ala Ala Ala Leu Leu Leu Trp Thr Pro Trp Thr Ala 
            20                  25                  30          


Gly Glu Val Glu Asp Ser Glu Ala Ile Asp Thr Leu Gly Gln Pro Asp 
        35                  40                  45              


Gly Pro Asp Ser Pro Leu Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Val Val Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Leu Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Tyr Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Asp Gln Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr Gln Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Cys Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Asn Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Ala Asp Tyr Arg Gly Met Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His Arg Leu Ser Ser 
            340                 345                 350         


Thr Glu Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Val Glu Leu Cys Asp Val Pro Pro Cys Ser Pro Arg Tyr Gly Ser 
385                 390                 395                 400 


Lys Met Gly 
            


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Ile Ser Ser Gly Gly Gly Tyr Thr 
1               5               


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

His Pro Arg Asp Phe Ser Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Gln Asp Val Gly His Tyr 
1               5       


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Trp Ala Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Gln Gln Tyr Asn Ile Tyr Pro Trp Thr 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Ile His Pro Gly Ser Gly Gly Thr 
1               5               


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Arg Arg Pro Arg Phe Tyr Gly Met Asp Tyr 
1               5                   10  


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Arg Met Ser 
1           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Gln His Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Ile Ser Ser Gly Gly Gly Ser Thr 
1               5               


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

His Pro Tyr Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Gln Ser Ile Gly Thr Ser 
1               5       


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Tyr Ala Ser 
1           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Gln Gln Ser Asp Ser Trp Pro Phe Pro 
1               5                   


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

His Gly Ser Ser Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Gln Glu Ile Ser Gly Tyr 
1               5       


<210>  47
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Ala Ala Ser 
1           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Leu Gln Tyr Ala Ser Tyr Pro Tyr Thr 
1               5                   


<210>  49
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  51
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

His Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Asn His Ile Leu Tyr Leu Gln Met Ser Ser Leu Asn Ser Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys Ala Arg 
        35                  40  


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  53
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  55
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Asp Tyr Phe Cys 
        35      


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Phe Gly Gly Gly Ser Lys Leu Ala Ile Lys 
1               5                   10  


<210>  57
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu 
            20                  25  


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  59
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Ala Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys Thr Arg 
        35                  40  


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  61
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  63
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Val Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  65
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  67
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys Ala Arg 
        35                  40  


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Asp Ile Leu Leu Thr Gln Ser Pro Asp Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser 
            20                  25      


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Lys 
    


<210>  71
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Phe Gly Ser Gly Thr Lys Leu Glu Lys Lys 
1               5                   10  


<210>  73
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Arg 
    


<210>  75
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Gln Ser Met Leu His Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys Val Arg 
        35                  40  


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:77

<400>  76

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  77
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser 
            20                  25      


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  78

Leu Gly Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  79
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  79

Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      


Ser Ala Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  80

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  81
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  81

Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala 
1               5                   10                  15      


Thr Gly Val His Ser 
            20      


<210>  82
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  82

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  83
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  83

Glu Phe 
1       


<210>  84
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  84

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
1               5                   10                  15      


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            20                  25                  30          


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        35                  40                  45              


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    50                  55                  60                  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
65                  70                  75                  80  


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                85                  90                  95      


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            100                 105                 110         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        115                 120                 125             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    130                 135                 140                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
145                 150                 155                 160 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Glu Ser Arg Trp 
                165                 170                 175     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            180                 185                 190         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205     


<210>  85
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  85

Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala 
1               5                   10                  15      


Thr Gly Val His Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Ile Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Gly His Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
            100                 105                 110         


Asn Ile Tyr Pro Trp Thr Phe Gly Gly Gly Ser Lys Leu Ala Ile Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                165                 170                 175     


Asn Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu 
            180                 185                 190         


Trp Val Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr His Tyr Val Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn His Ile 
    210                 215                 220                 


Leu Tyr Leu Gln Met Ser Ser Leu Asn Ser Glu Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg His Pro Arg Asp Phe Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Glu Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  86
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  86

Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala 
1               5                   10                  15      


Thr Gly Val His Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Leu Thr Val Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Leu 
                165                 170                 175     


Gly Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro 
            180                 185                 190         


Val His Gly Leu Glu Trp Ile Gly Ala Ile His Pro Gly Ser Gly Gly 
        195                 200                 205             


Thr Ala Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Thr Arg Arg Arg Pro Arg Phe Tyr Gly 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Glu Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  87
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  87
gccaccatgg gatggtcatg tatcatcctt tttctagtag caactgcaac cggtgtacat       60

tcc                                                                     63


<210>  88
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
ggctccacct ctggatccgg caagcccgga tctggcgagg gatccaccaa gggc             54


<210>  89
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  89
gaattc                                                                   6


<210>  90
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  90
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc       60

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      120

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      180

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      240

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      300

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      360

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg      420

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac      480

ggctccttct tcctctatag caagctcacc gtggacgaga gcaggtggca gcaggggaac      540

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      600

tccctgtctc cgggtaaatg a                                                621


<210>  91
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  91
gccaccatgg gatggtcatg tatcatcctt tttctagtag caactgcaac cggtgtacat       60

tccgacattg tgatgaccca gtctcacaaa ttcatgtcca catcaatagg agacagggtc      120

agcatcacct gcaaggccag tcaggatgtg ggtcattatg tggcctggta tcaacagaaa      180

ccaggtcaat ctcctaaact actgatttac tgggcatcca cccggcacac tggagtccct      240

gatcgcttca caggtagtgg atctgggaca gatttcactc tcaccattag caatgtgcag      300

tctgaagact tggcagatta tttctgtcag caatataaca tctatccgtg gacgttcggt      360

ggaggctcca agctggcaat caaaggctcc acctctggat ccggcaagcc cggatctggc      420

gagggatcta ccaagggcga ggtgcagctg gtggagtctg ggggagactt agtgaagcct      480

ggagggtccc tgaaactctc ctgtgcagcc tctggattca ctttcagtaa ttatggcatg      540

tcttgggttc gccagactcc agacaagagg ctggagtggg tcgcaaccat tagtagtggt      600

ggtggttaca ctcactatgt agacagtgtg aaggggcgat tcaccatttc cagagacaat      660

gccaaccata tcctgtacct gcaaatgagc agtctgaact ctgaggacac agccatgtat      720

tattgtgcaa gacacccgag ggatttttcc tatgctatgg actactgggg tcagggaacc      780

tcagtcaccg tctcctcaga attcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     1320

gagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  92
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  92
gccaccatgg gatggtcatg tatcatcctt tttctagtag caactgcaac cggtgtacat       60

tccgatattg tgatgactca ggctgcaccc tctgtacctg tcactcctgg agagtcagta      120

tccatctcct gcaggtctag taagagtctc ctgcatagta atggcaacac ttacttgtat      180

tggttcctgc agaggccagg ccagtctcct cagctcctga tatatcggat gtccaacctt      240

gcctcaggag tcccagacag gttcagtggc agtgggtcag gaactgcttt cacactgaga      300

atcagtagag tggaggctga ggatgtgggt gtttattact gtatgcaaca tctagaatat      360

cctctcacgg tcggtgctgg gaccaagctg gagctgaaag gctccacctc tggatccggc      420

aagcccggat ctggcgaggg atctaccaag ggccaggttc aactgcaaca gtctggggct      480

gagctggtga ggcctggggc ttcagtgaag ctgtcctgca aggctttggg ctacacattt      540

actgactatg aaatgcactg ggtgaagcag acacctgtgc atggcctgga atggattgga      600

gctattcatc caggaagtgg tggtactgcc tataatcaga agttcaaggg caaggccaca      660

ctgactgcag acaaatcctc cagcacagcc tacatggagc tcagcaggct gacatctgag      720

gactctgctg tctattactg tacaagaagg aggcctaggt tctatggtat ggactactgg      780

ggtcaaggaa cctcagtcac cgtctcctca gaattcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      900

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1080

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1140

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1320

ctcaccgtgg acgagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga        1437


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  93

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Val Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  95
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:96

<400>  95

Val Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Lys 
1               5                   10                  15      


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            20                  25                  30          


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        35                  40                  45              


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    50                  55                  60                  


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
65                  70                  75                  80  


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                85                  90                  95      


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            100                 105                 110         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        115                 120                 125             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    130                 135                 140                 


Gly Lys Met 
145         


<210>  96
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Val Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            100                 105                 110         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Leu Gly Lys Met 
225                 230         


<210>  97
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  98
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  99
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  100
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
            20                  25                  30          


Ser Ile Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Gly His Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
                85                  90                  95      


Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ile 
            100                 105                 110         


Tyr Pro Trp Thr Phe Gly Gly Gly Ser Lys Leu Ala Ile Lys Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
            180                 185                 190         


Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr His Tyr Val Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn His Ile Leu Tyr 
    210                 215                 220                 


Leu Gln Met Ser Ser Leu Asn Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg His Pro Arg Asp Phe Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Val Asp Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met 
                485                 490                 495     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            500                 505                 510         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        515                 520                 525             


Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    530                 535                 540                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
545                 550                 555                 560 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                565                 570                 575     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            580                 585                 590         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        595                 600                 605             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    610                 615                 620                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
625                 630                 635                 640 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                645                 650                 655     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            660                 665                 670         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        675                 680                 685             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    690                 695                 700                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715             


<210>  101
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              


Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
                85                  90                  95      


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Met Gln His Leu Glu Tyr Pro Leu Thr Val Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
145                 150                 155                 160 


Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Ala Ile His Pro Gly Ser Gly Gly Thr Ala 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Arg Arg Pro Arg Phe Tyr Gly Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Asp Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        515                 520                 525             


Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro 
    530                 535                 540                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
545                 550                 555                 560 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
                565                 570                 575     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            580                 585                 590         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        595                 600                 605             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    610                 615                 620                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
625                 630                 635                 640 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                645                 650                 655     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            660                 665                 670         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        675                 680                 685             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    690                 695                 700                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
705                 710                 715                 720 


Pro Arg 
        


<210>  102
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                405                 410                 415     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            420                 425                 430         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        435                 440                 445             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    450                 455                 460                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
465                 470                 475                 480 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                485                 490                 495     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            500                 505                 510         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        515                 520                 525             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    530                 535                 540                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
545                 550                 555                 560 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                565                 570                 575     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            580                 585                 590         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        595                 600                 605             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    610                 615                 620                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 


<210>  103
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                405                 410                 415     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            420                 425                 430         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        435                 440                 445             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    450                 455                 460                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
465                 470                 475                 480 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                485                 490                 495     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            500                 505                 510         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        515                 520                 525             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    530                 535                 540                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
545                 550                 555                 560 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                565                 570                 575     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            580                 585                 590         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        595                 600                 605             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    610                 615                 620                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 


<210>  104
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  104
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc          57


<210>  105
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  105
gtcgacgagt ccaaatatgg tcccccatgc ccaccatgcc ca                          42


<210>  106
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  106
gtcgacgagt ccaaatatgg tcccccatgc ccaccatgcc caggcaagga gtacaagtgc       60

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg      120

cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac      180

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      240

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac      300

ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat      360

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      420

tccctgtccc taggtaaaat g                                                441


<210>  107
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  107
gtcgacgagt ccaaatatgg tcccccatgc ccaccatgcc cagcacctga gttcctgggg       60

ggaccatcag tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc      120

cctgaggtca cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac      180

tggtacgtgg atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc      300

aaggagtaca agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag      420

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaggc taaccgtgga caagagcagg      600

tggcaggagg ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acacagaaga gcctctccct gtccctaggt aaaatg                                696


<210>  108
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  108
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      120

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      180

cgcgacttcg cagcctatcg ctcc                                             204


<210>  109
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  109
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  110
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  110
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctga                             339


<210>  111
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  111
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgac       60

attgtgatga cccagtctca caaattcatg tccacatcaa taggagacag ggtcagcatc      120

acctgcaagg ccagtcagga tgtgggtcat tatgtggcct ggtatcaaca gaaaccaggt      180

caatctccta aactactgat ttactgggca tccacccggc acactggagt ccctgatcgc      240

ttcacaggta gtggatctgg gacagatttc actctcacca ttagcaatgt gcagtctgaa      300

gacttggcag attatttctg tcagcaatat aacatctatc cgtggacgtt cggtggaggc      360

tccaagctgg caatcaaagg ctccacctct ggatccggca agcccggatc tggcgaggga      420

tccaccaagg gcgaggtgca gctggtggag tctgggggag acttagtgaa gcctggaggg      480

tccctgaaac tctcctgtgc agcctctgga ttcactttca gtaattatgg catgtcttgg      540

gttcgccaga ctccagacaa gaggctggag tgggtcgcaa ccattagtag tggtggtggt      600

tacactcact atgtagacag tgtgaagggg cgattcacca tttccagaga caatgccaac      660

catatcctgt acctgcaaat gagcagtctg aactctgagg acacagccat gtattattgt      720

gcaagacacc cgagggattt ttcctatgct atggactact ggggtcaggg aacctcagtc      780

accgtctcct cagtcgacga gtccaaatat ggtcccccat gcccaccatg cccagcacct      840

gagttcctgg ggggaccatc agtcttcctg ttccccccaa aacccaagga cactctcatg      900

atctcccgga cccctgaggt cacgtgcgtg gtggtggacg tgagccagga agaccccgag      960

gtccagttca actggtacgt ggatggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt tcaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaacg gcaaggagta caagtgcaag gtctccaaca aaggcctccc gtcctccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagagc cacaggtgta caccctgccc     1200

ccatcccagg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

taccccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcag gctaaccgtg     1380

gacaagagca ggtggcagga ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacacagaa gagcctctcc ctgtccctag gtaaaatgtt ttgggtgctg     1500

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1560

ttctgggtga ggagtaagag gagcaggggc ggacacagtg actacatgaa catgactccc     1620

cgccgccctg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1680

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1740

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1800

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag     1860

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1920

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1980

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     2040

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     2100

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctga        2157


<210>  112
<211>  2169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  112
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgat       60

attgtgatga ctcaggctgc accctctgta cctgtcactc ctggagagtc agtatccatc      120

tcctgcaggt ctagtaagag tctcctgcat agtaatggca acacttactt gtattggttc      180

ctgcagaggc caggccagtc tcctcagctc ctgatatatc ggatgtccaa ccttgcctca      240

ggagtcccag acaggttcag tggcagtggg tcaggaactg ctttcacact gagaatcagt      300

agagtggagg ctgaggatgt gggtgtttat tactgtatgc aacatctaga atatcctctc      360

acggtcggtg ctgggaccaa gctggagctg aaaggctcca cctctggatc cggcaagccc      420

ggatctggcg agggatccac caagggccag gttcaactgc aacagtctgg ggctgagctg      480

gtgaggcctg gggcttcagt gaagctgtcc tgcaaggctt tgggctacac atttactgac      540

tatgaaatgc actgggtgaa gcagacacct gtgcatggcc tggaatggat tggagctatt      600

catccaggaa gtggtggtac tgcctataat cagaagttca agggcaaggc cacactgact      660

gcagacaaat cctccagcac agcctacatg gagctcagca ggctgacatc tgaggactct      720

gctgtctatt actgtacaag aaggaggcct aggttctatg gtatggacta ctggggtcaa      780

ggaacctcag tcaccgtctc ctcagtcgac gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtccct aggtaaaatg     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggg gcggacacag tgactacatg     1620

aacatgactc cccgccgccc tgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctccaaacgg ggcagaaaga aactcctgta tatattcaaa     1740

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1800

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1860

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1920

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1980

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     2040

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     2100

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     2160

cctcgctga                                                             2169


<210>  113
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  113

His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly Thr Ala Ser 
1               5                   10                  15      


Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu Gln His Pro 
            20                  25                  30          


His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu Leu Gly Gly Gly 
        35                  40                  45              


His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Cys 
    50                  55                  60                  


Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp Val Pro Ser 
65                  70                  75                  80  


Cys Ser 
        


<210>  114
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  114

Ala Ile Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg 
1               5                   10                  15      


Trp Leu Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile 
            20                  25                  30          


Ile Arg Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp 
        35                  40                  45              


Thr Thr Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys 
    50                  55                  60                  


Thr Ile Thr Ala Thr 
65                  


