                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF MICHIGAN
 
<120>  POLYPEPTIDE INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY AND USES 
       THEREOF

<130>  UM-37987.601

<150>  US 62/938,859
<151>  2019-11-21

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  4080
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  1
gaattcctgc agctcagcag ccgccgccag agcaggacga accgccaatc gcaaggcacc       60

cttaaggacg tcgagtcgtc ggcggcggtc tcgtcctgct tggcggttag cgttccgtgg      120

tctgagaact tcaggatgca gatgtctcca gccctcacct gcctagtcct gggcctggcc      180

agactcttga agtcctacgt ctacagaggt cgggagtgga cggatcagga cccggaccgg      240

cttgtctttg gtgaagggtc tgctgtgcac catcccccat cctacgtggc ccacctggcc      300

gaacagaaac cacttcccag acgacacgtg gtagggggta ggatgcaccg ggtggaccgg      360

tcagacttcg gggtgagggt gtttcagcag gtggcgcagg cctccaagga ccgcaacgtg      420

agtctgaagc cccactccca caaagtcgtc caccgcgtcc ggaggttcct ggcgttgcac      480

gttttctcac cctatggggt ggcctcggtg ttggccatgc tccagctgac aacaggagga      540

caaaagagtg ggatacccca ccggagccac aaccggtacg aggtcgactg ttgtcctcct      600

gaaacccagc agcagattca agcagctatg ggattcaaga ttgatgacaa gggcatggcc      660

ctttgggtcg tcgtctaagt tcgtcgatac cctaagttct aactactgtt cccgtaccgg      720

cccgccctcc ggcatctgta caaggagctc atggggccat ggaacaagga tgagatcagc      780

gggcgggagg ccgtagacat gttcctcgag taccccggta ccttgttcct actctagtcg      840

accacagacg cgatcttcgt ccagcgggat ctgaagctgg tccagggctt catgccccac      900

tggtgtctgc gctagaagca ggtcgcccta gacttcgacc aggtcccgaa gtacggggtg      960

ttcttcaggc tgttccggag cacggtcaag caagtggact tttcagaggt ggagagagcc     1020

aagaagtccg acaaggcctc gtgccagttc gttcacctga aaagtctcca cctctctcgg     1080

agattcatca tcaatgactg ggtgaagaca cacacaaaag gtatgatcag caacttgctt     1140

tctaagtagt agttactgac ccacttctgt gtgtgttttc catactagtc gttgaacgaa     1200

gggaaaggag ccgtggacca gctgacacgg ctggtgctgg tgaatgccct ctacttcaac     1260

ccctttcctc ggcacctggt cgactgtgcc gaccacgacc acttacggga gatgaagttg     1320

ggccagtgga agactccctt ccccgactcc agcacccacc gccgcctctt ccacaaatca     1380

ccggtcacct tctgagggaa ggggctgagg tcgtgggtgg cggcggagaa ggtgtttagt     1440

gacggcagca ctgtctctgt gcccatgatg gctcagacca acaagttcaa ctatactgag     1500

ctgccgtcgt gacagagaca cgggtactac cgagtctggt tgttcaagtt gatatgactc     1560

ttcaccacgc ccgatggcca ttactacgac atcctggaac tgccctacca cggggacacc     1620

aagtggtgcg ggctaccggt aatgatgctg taggaccttg acgggatggt gcccctgtgg     1680

ctcagcatgt tcattgctgc cccttatgaa aaagaggtgc ctctctctgc cctcaccaac     1740

gagtcgtaca agtaacgacg gggaatactt tttctccacg gagagagacg ggagtggttg     1800

attctgagtg cccagctcat cagccactgg aaaggcaaca tgaccaggct gccccgcctc     1860

taagactcac gggtcgagta gtcggtgacc tttccgttgt actggtccga cggggcggag     1920

ctggttctgc ccaagttctc cctggagact gaagtcgacc tcaggaagcc cctagagaac     1980

gaccaagacg ggttcaagag ggacctctga cttcagctgg agtccttcgg ggatctcttg     2040

ctgggaatga ccgacatgtt cagacagttt caggctgact tcacgagtct ttcagaccaa     2100

gacccttact ggctgtacaa gtctgtcaaa gtccgactga agtgctcaga aagtctggtt     2160

gagcctctcc acgtcgcgca ggcgctgcag aaagtgaaga tcgaggtgaa cgagagtggc     2220

ctcggagagg tgcagcgcgt ccgcgacgtc tttcacttct agctccactt gctctcaccg     2280

acggtggcct cctcatccac agctgtcata gtctcagccc gcatggcccc cgaggagatc     2340

tgccaccgga ggagtaggtg tcgacagtat cagagtcggg cgtaccgggg gctcctctag     2400

atcatggaca gacccttcct ctttgtggtc cggcacaacc ccacaggaac agtccttttc     2460

tagtacctgt ctgggaagga gaaacaccag gccgtgttgg ggtgtccttg tcaggaaaag     2520

atgggccaag tgatggaacc ctgaccctgg ggaaagacgc cttcatctgg gacaaaactg     2580

tacccggttc actaccttgg gactgggacc cctttctgcg gaagtagacc ctgttttgac     2640

gagatgcatc gggaaagaag aaactccgaa gaaaagaatt ttagtgttaa tgactctttc     2700

ctctacgtag ccctttcttc tttgaggctt cttttcttaa aatcacaatt actgagaaag     2760

tgaaggaaga gaagacattt gccttttgtt aaaagatggt aaaccagatc tgtctccaag     2820

acttccttct cttctgtaaa cggaaaacaa ttttctacca tttggtctag acagaggttc     2880

accttggcct ctccttggag gacctttagg tcaaactccc tagtctccac ctgagaccct     2940

tggaaccgga gaggaacctc ctggaaatcc agtttgaggg atcagaggtg gactctggga     3000

gggagagaag tttgaagcac aactccctta aggtctccaa accagacggt gacgcctgcg     3060

ccctctcttc aaacttcgtg ttgagggaat tccagaggtt tggtctgcca ctgcggacgc     3120

ggaccatctg gggcacctgc ttccacccgt ctctctgccc actcgggtct gcagacctgg     3180

cctggtagac cccgtggacg aaggtgggca gagagacggg tgagcccaga cgtctggacc     3240

ttcccactga ggccctttgc aggatggaac tacggggctt acaggagctt ttgtgtgcct     3300

aagggtgact ccgggaaacg tcctaccttg atgccccgaa tgtcctcgaa aacacacgga     3360

ggtagaaact atttctgttc cagtcacatt gccatcactc ttgtactgcc tgccaccgcg     3420

ccatctttga taaagacaag gtcagtgtaa cggtagtgag aacatgacgg acggtggcgc     3480

gaggaggctg gtgacaggcc aaaggccagt ggaagaaaca ccctttcatc tcagagtcca     3540

ctcctccgac cactgtccgg tttccggtca ccttctttgt gggaaagtag agtctcaggt     3600

ctgtggcact ggccacccct ccccagtaca ggggtgctgc aggtggcaga gtgaatgtcc     3660

gacaccgtga ccggtgggga ggggtcatgt ccccacgacg tccaccgtct cacttacagg     3720

cccatcatgt ggcccaactc tcctggcctg gccatctccc tccccagaaa cagtgtgcat     3780

gggtagtaca ccgggttgag aggaccggac cggtagaggg aggggtcttt gtcacacgta     3840

gggttatttt ggagtgtagg tgacttgttt actcattgaa gcagatttct gcttcctttt     3900

cccaataaaa cctcacatcc actgaacaaa tgagtaactt cgtctaaaga cgaaggaaaa     3960

atttttatag gaatagagga agaaatgtca gatgcgtgcc cagctcttca ccccccaatc     4020

taaaaatatc cttatctcct tctttacagt ctacgcacgg gtcgagaagt ggggggttag     4080


<210>  2
<211>  402
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  3
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly 
1               5                   10                  15      


Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val 
            20                  25                  30          


Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu 
        35                  40                  45              


Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala Met Gly Phe 
    50                  55                  60                  


Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu Arg His Leu Tyr Lys 
65                  70                  75                  80  


Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala 
                85                  90                  95      


Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His 
            100                 105                 110         


Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu 
        115                 120                 125             


Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr 
    130                 135                 140                 


Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val Asp Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys 
                165                 170                 175     


Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser 
            180                 185                 190         


Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe 
        195                 200                 205             


Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu 
    210                 215                 220                 


Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro 
225                 230                 235                 240 


Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala 
                245                 250                 255     


Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr Arg Leu Pro Arg Leu 
            260                 265                 270         


Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys 
        275                 280                 285             


Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala 
    290                 295                 300                 


Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu His Val Ala Gln Ala 
305                 310                 315                 320 


Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser 
                325                 330                 335     


Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met Ala Pro Glu Glu Ile 
            340                 345                 350         


Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly 
        355                 360                 365             


Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
    370                 375                 


<210>  4
<211>  2352
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4
gtgcaccatc ccccatccta cgtggcccac ctggcccacg tggtaggggg taggatgcac       60

cgggtggacc ggtcagactt cggggtgagg gtgtttcagc aggtggcgca ggcctccaag      120

gaccgcaacg tgagtctgaa gccccactcc cacaaagtcg tccaccgcgt ccggaggttc      180

ctggcgttgc acgttttctc accctatggg gtggcctcgg tgttggccat gctccagctg      240

acaacaggag gacaaaagag tgggataccc caccggagcc acaaccggta cgaggtcgac      300

tgttgtcctc ctgaaaccca gcagcagatt caagcagcta tgggattcaa gattgatgac      360

gcgggcatgg ccctttgggt cgtcgtctaa gttcgtcgat accctaagtt ctaactactg      420

cgcccgtacc ggcccgccct ccggcatctg taccgggagc tcatggggcc atggaacgcg      480

gatgagctca gcgggcggga ggccgtagac atggccctcg agtaccccgg taccttgcgc      540

ctactcgagt cgaccacaga cgcgatcttc gtccaggcgg atctgaagct ggtccagggc      600

ttcatgcccc actggtgtct gcgctagaag caggtccgcc tagacttcga ccaggtcccg      660

aagtacgggg tgttcttcag gctgttccgg agcacggtcg cgaaagtgga cttttcagag      720

gtggagagag ccaagaagtc cgacaaggcc tcgtgccagc gctttcacct gaaaagtctc      780

cacctctctc ggagattcat catcaatgac tgggtgaaga cacacacaaa aggtatgatc      840

agcaacttgc tttctaagta gtagttactg acccacttct gtgtgtgttt tccatactag      900

tcgttgaacg aagggaaagg agccgtggac cagctgacac ggctggtgct ggtgaatgcc      960

ctctacttca acccctttcc tcggcacctg gtcgactgtg ccgaccacga ccacttacgg     1020

gagatgaagt tgggccagtg ggcgactccc ttccccgact ccagcaccca ccgccgcctc     1080

ttccacaaat caccggtcac ccgctgaggg aaggggctga ggtcgtgggt ggcggcggag     1140

aaggtgttta gtgacggcag cactgtctct gtgcccatga tggctcagac caacgcgttc     1200

aactatactg agctgccgtc gtgacagaga cacgggtact accgagtctg gttgcgcaag     1260

ttgatatgac tcttcaccac gcccgatggc cattactacg acatcctgga actgccctac     1320

cacggggaca ccaagtggtg cgggctaccg gtaatgatgc tgtaggacct tgacgggatg     1380

gtgcccctgt ggctcagcat gttcattgct gccccttatg aaaaagaggt gcctctctct     1440

gccctcacca acgagtcgta caagtaacga cggggaatac tttttctcca cggagagaga     1500

cgggagtggt tgattctgag tgcccagctc atcagccact gggcaggcaa catgaccagg     1560

ctgccccgcc tctaagactc acgggtcgag tagtcggtga cccgtccgtt gtactggtcc     1620

gacggggcgg agctggttct gcccaagttc tccctggaga ctgaagtcga cctcaggaag     1680

cccctagaga acgaccaaga cgggttcaag agggacctct gacttcagct ggagtccttc     1740

ggggatctct tgctgggaat gaccgacatg ttcagacagt ttcaggctga cttcacgagt     1800

ctttcagacc aagaccctta ctggctgtac aagtctgtca aagtccgact gaagtgctca     1860

gaaagtctgg ttgagcctct ccacgtcgcg caggcgctgc agaaagtgaa gatcgaggtg     1920

aacgagagtg gcctcggaga ggtgcagcgc gtccgcgacg tctttcactt ctagctccac     1980

ttgctctcac cgacggtggc ctcctcatcc acagctgtca tagcctcagc cgtcatggcc     2040

cccgaggaga tctgccaccg gaggagtagg tgtcgacagt atcggagtcg gcagtaccgg     2100

gggctcctct agatcatgga cagacccttc ctctttgtgg tccggcacaa ccccacagga     2160

acagtccttt tctagtacct gtctgggaag gagaaacacc aggccgtgtt ggggtgtcct     2220

tgtcaggaaa agatgggcca agtgatggaa ccctgaccct ggggaaagac gccttcatct     2280

gggacaaaac tgtacccggt tcactacctt gggactggga cccctttctg cggaagtaga     2340

ccctgttttg ac                                                         2352


<210>  5
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5

Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly 
1               5                   10                  15      


Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val 
            20                  25                  30          


Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu 
        35                  40                  45              


Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala Met Gly Phe 
    50                  55                  60                  


Lys Ile Asp Asp Ala Gly Met Ala Pro Ala Leu Arg His Leu Tyr Ala 
65                  70                  75                  80  


Glu Leu Met Gly Pro Trp Asn Ala Asp Glu Leu Ser Thr Thr Asp Ala 
                85                  90                  95      


Ile Phe Val Gln Ala Asp Leu Lys Leu Val Gln Gly Phe Met Pro His 
            100                 105                 110         


Phe Phe Arg Leu Phe Arg Ser Thr Val Ala Lys Val Asp Phe Ser Glu 
        115                 120                 125             


Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr 
    130                 135                 140                 


Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val Asp Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Ala 
                165                 170                 175     


Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser 
            180                 185                 190         


Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Ala Phe 
        195                 200                 205             


Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu 
    210                 215                 220                 


Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro 
225                 230                 235                 240 


Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala 
                245                 250                 255     


Gln Leu Ile Ser His Trp Ala Gly Asn Met Thr Arg Leu Pro Arg Leu 
            260                 265                 270         


Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys 
        275                 280                 285             


Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala 
    290                 295                 300                 


Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu His Val Ala Gln Ala 
305                 310                 315                 320 


Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser 
                325                 330                 335     


Ser Ser Thr Ala Val Ile Ala Ser Ala Val Met Ala Pro Glu Glu Ile 
            340                 345                 350         


Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly 
        355                 360                 365             


Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
    370                 375                 


<210>  6
<211>  3834
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgc acttgtcacg       60

tacatgtcct acgttgagga cagaacgtaa cgtgattcag aacgtgaacg tgaacagtgc      120

aattcggcac ctctcgagcc caaatctagt gacaaaactc acacatgccc accgtgccca      180

ttaagccgtg gagagctcgg gtttagatca ctgttttgag tgtgtacggg tggcacgggt      240

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      300

cgtggacttg aggacccccc tggcagtcag aaggagaagg ggggttttgg gttcctgtgg      360

ctctacatca cccgggaacc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      420

gagatgtagt gggcccttgg actccagtgt acgcaccacc acctgcactc ggtgcttctg      480

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      540

ggactccagt tcaagttgac catgcacctg ccgcacctcc acgtattacg gttctgtttc      600

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      660

ggcgccctcc tcgtcatgtt gtcgtgcatg gcacaccagt cgcaggagtg gcaggacgtg      720

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      780

gtcctgaccg acttaccgtt cctcatgttc acgttccaga ggttgtttcg ggagggtcgg      840

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc      900

gggtagctct tttggtagag gtttcggttt cccgtcgggg ctcttggtgt ccacatgtgg      960

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1020

gacgggggta gggccctcct ctactggttc ttggtccagt cggactggac ggaccagttt     1080

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1140

ccgaagatag ggtcgctgta gcggcacctc accctctcgt tacccgtcgg cctcttgttg     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

atgttctggt gcggagggca cgacctgagg ctgccgagga agaaggagat gtcgttcgag     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

tggcacctgt tctcgtccac cgtcgtcccc ttgcagaaga gtacgaggca ctacgtactc     1440

gctctgaagt tccactacac gcagaagagc ctctccctgt ctccgggtgc aactagtgtg     1500

cgagacttca aggtgatgtg cgtcttctcg gagagggaca gaggcccacg ttgatcacac     1560

caccatcccc catcctacgt ggcccacctg gcctcagact tcggggtgag ggtgtttcag     1620

gtggtagggg gtaggatgca ccgggtggac cggagtctga agccccactc ccacaaagtc     1680

caggtggcgc aggcctccaa ggaccgcaac gtggttttct caccctatgg ggtggcctcg     1740

gtccaccgcg tccggaggtt cctggcgttg caccaaaaga gtgggatacc ccaccggagc     1800

gtgttggcca tgctccagct gacaacagga ggagaaaccc agcagcagat tcaagcagct     1860

cacaaccggt acgaggtcga ctgttgtcct cctctttggg tcgtcgtcta agttcgtcga     1920

atgggattca agattgatga caagggcatg gcccccgccc tccggcatct gtacaaggag     1980

taccctaagt tctaactact gttcccgtac cgggggcggg aggccgtaga catgttcctc     2040

ctcatggggc catggaacaa ggatgagctc agcaccacag acgcgatctt cgtccaggcg     2100

gagtaccccg gtaccttgtt cctactcgag tcgtggtgtc tgcgctagaa gcaggtccgc     2160

gatctgaagc tggtccaggg cttcatgccc cacttcttca ggctgttccg gagcacggtc     2220

ctagacttcg accaggtccc gaagtacggg gtgaagaagt ccgacaaggc ctcgtgccag     2280

aagaaagtgg acttttcaga ggtggagaga gccagattca tcatcaatga ctgggtgaag     2340

ttctttcacc tgaaaagtct ccacctctct cggtctaagt agtagttact gacccacttc     2400

acacacacaa aaggtatgat cagcaacttg cttgggaaag gagccgtgga ccagctgaca     2460

tgtgtgtgtt ttccatacta gtcgttgaac gaaccctttc ctcggcacct ggtcgactgt     2520

cggctggtgc tggtgaatgc cctctacttc aacggccagt ggaagactcc cttccccgac     2580

gccgaccacg accacttacg ggagatgaag ttgccggtca ccttctgagg gaaggggctg     2640

tccagcaccc accgccgcct cttccacaaa tcagacggca gcactgtctc tgtgcccatg     2700

aggtcgtggg tggcggcgga gaaggtgttt agtctgccgt cgtgacagag acacgggtac     2760

atggctcaga ccaacaagtt caactatact gagttcacca cgcccgatgg ccattactac     2820

taccgagtct ggttgttcaa gttgatatga ctcaagtggt gcgggctacc ggtaatgatg     2880

gacatcctgg aactgcccta ccacggggac accctcagca tgttcattgc tgccccttat     2940

ctgtaggacc ttgacgggat ggtgcccctg tgggagtcgt acaagtaacg acggggaata     3000

gaaaaagagg tgcctctctc tgccctcacc aacattctga gtgcccagct catcagccac     3060

ctttttctcc acggagagag acgggagtgg ttgtaagact cacgggtcga gtagtcggtg     3120

tggaaaggca acatgaccag gctgccccgc ctcctggttc tgcccaagtt ctccctggag     3180

acctttccgt tgtactggtc cgacggggcg gaggaccaag acgggttcaa gagggacctc     3240

actgaagtcg acctcaggaa gcccctagag aacctgggaa tgaccgacat gttcagacag     3300

tgacttcagc tggagtcctt cggggatctc ttggaccctt actggctgta caagtctgtc     3360

tttcaggctg acttcacgag tctttcagac caagagcctc tccacgtcgc gcaggcgctg     3420

aaagtccgac tgaagtgctc agaaagtctg gttctcggag aggtgcagcg cgtccgcgac     3480

cagaaagtga agatcgaggt gaacgagagt ggcacggtgg cctcctcatc cacagctgtc     3540

gtctttcact tctagctcca cttgctctca ccgtgccacc ggaggagtag gtgtcgacag     3600

atagcctcag ccgtcatggc ccccgaggag atcatcatgg acagaccctt cctctttgtg     3660

tatcggagtc ggcagtaccg ggggctcctc tagtagtacc tgtctgggaa ggagaaacac     3720

gtccggcaca accccacagg aacagtcctt ttcatgggcc aagtgatgga accctgacag     3780

gccgtgttgg ggtgtccttg tcaggaaaag tacccggttc actaccttgg gact           3834


<210>  7
<211>  638
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Ala Leu Val Thr Asn Ser Ala Pro Leu Glu Pro Lys Ser Ser Asp Lys 
            20                  25                  30          


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        35                  40                  45              


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr 
    50                  55                  60                  


Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
65                  70                  75                  80  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                85                  90                  95      


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            100                 105                 110         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        115                 120                 125             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    130                 135                 140                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
145                 150                 155                 160 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                165                 170                 175     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            180                 185                 190         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        195                 200                 205             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
225                 230                 235                 240 


Ala Leu Lys Phe His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                245                 250                 255     


Ala Thr Ser Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser 
            260                 265                 270         


Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp 
        275                 280                 285             


Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met 
    290                 295                 300                 


Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala 
305                 310                 315                 320 


Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu Arg His 
                325                 330                 335     


Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Leu Ser Thr 
            340                 345                 350         


Thr Asp Ala Ile Phe Val Gln Ala Asp Leu Lys Leu Val Gln Gly Phe 
        355                 360                 365             


Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Lys Val Asp 
    370                 375                 380                 


Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys 
385                 390                 395                 400 


Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val 
                405                 410                 415     


Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly 
            420                 425                 430         


Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe 
        435                 440                 445             


His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr 
    450                 455                 460                 


Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr 
465                 470                 475                 480 


Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile 
                485                 490                 495     


Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile 
            500                 505                 510         


Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr Arg Leu 
        515                 520                 525             


Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp 
    530                 535                 540                 


Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln 
545                 550                 555                 560 


Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu His Val 
                565                 570                 575     


Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr 
            580                 585                 590         


Val Ala Ser Ser Ser Thr Ala Val Ile Ala Ser Ala Val Met Ala Pro 
        595                 600                 605             


Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn 
    610                 615                 620                 


Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
625                 630                 635             


