                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  Treatment for Physiological Iron Overload

<130>  K00066-1 WO

<150>  GB1917524.9
<151>  2019-11-29

<150>  GB1917882.1
<151>  2019-12-06

<160>  580   

<170>  PatentIn version 3.5

<210>  1
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val 
    850                 855 


<210>  2
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Leu Phe His Ser Lys Arg Met Pro Val Ala Glu Ala Pro 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu Glu Ala Glu 
            20                  25                  30          


Pro Glu Gly Met Phe Lys Ala Cys Glu Asp Ser Lys Arg Lys Ala Arg 
        35                  40                  45              


Gly Tyr Leu Arg Leu Val Pro Leu Phe Val Leu Leu Ala Leu Leu Val 
    50                  55                  60                  


Leu Ala Ser Ala Gly Val Leu Leu Trp Tyr Phe Leu Gly Tyr Lys Ala 
65                  70                  75                  80  


Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn 
                85                  90                  95      


Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg 
            100                 105                 110         


Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Thr Ser 
        115                 120                 125             


Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly 
    130                 135                 140                 


Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu 
145                 150                 155                 160 


His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val 
                165                 170                 175     


Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg 
            180                 185                 190         


Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His 
225                 230                 235                 240 


Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met 
                245                 250                 255     


Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu 
            260                 265                 270         


Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr 
305                 310                 315                 320 


Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu 
                325                 330                 335     


Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser 
            340                 345                 350         


Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln 
                405                 410                 415     


Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile 
            420                 425                 430         


Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His 
        435                 440                 445             


Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys 
    450                 455                 460                 


Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys 
465                 470                 475                 480 


Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln 
                485                 490                 495     


Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly 
            500                 505                 510         


Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly 
        515                 520                 525             


Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val 
    530                 535                 540                 


Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly 
545                 550                 555                 560 


Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg 
                565                 570                 575     


Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala 
            580                 585                 590         


Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala 
        595                 600                 605             


Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met 
    610                 615                 620                 


Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn 
625                 630                 635                 640 


Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu 
                645                 650                 655     


His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu 
            660                 665                 670         


Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys 
        675                 680                 685             


Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile 
    690                 695                 700                 


Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu 
705                 710                 715                 720 


Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val 
                725                 730                 735     


Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys 
            740                 745                 750         


Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly 
    770                 775                 780                 


Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr 
785                 790                 795                 800 


Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr 
                805                 810     


<210>  3
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Lys Glu Asn Ser Asp Val Ser Ala Ala Pro Ala Asp Leu Lys 
1               5                   10                  15      


Ile Ser Asn Ile Ser Val Gln Val Val Ser Ala Gln Lys Lys Leu Pro 
            20                  25                  30          


Val Arg Arg Pro Pro Leu Pro Gly Arg Arg Leu Pro Leu Pro Gly Arg 
        35                  40                  45              


Arg Pro Pro Gln Arg Pro Ile Gly Lys Ala Lys Pro Lys Lys Gln Ser 
    50                  55                  60                  


Lys Lys Lys Val Pro Phe Trp Asn Val Gln Asn Lys Ile Ile Leu Phe 
65                  70                  75                  80  


Thr Val Phe Leu Phe Ile Leu Ala Val Ile Ala Trp Thr Leu Leu Trp 
                85                  90                  95      


Leu Tyr Ile Ser Lys Thr Glu Ser Lys Asp Ala Phe Tyr Phe Ala Gly 
            100                 105                 110         


Met Phe Arg Ile Thr Asn Ile Glu Phe Leu Pro Glu Tyr Arg Gln Lys 
        115                 120                 125             


Glu Ser Arg Glu Phe Leu Ser Val Ser Arg Thr Val Gln Gln Val Ile 
    130                 135                 140                 


Asn Leu Val Tyr Thr Thr Ser Ala Phe Ser Lys Phe Tyr Glu Gln Ser 
145                 150                 155                 160 


Val Val Ala Asp Val Ser Ser Asn Asn Lys Gly Gly Leu Leu Val His 
                165                 170                 175     


Phe Trp Ile Val Phe Val Met Pro Arg Ala Lys Gly His Ile Phe Cys 
            180                 185                 190         


Glu Asp Cys Val Ala Ala Ile Leu Lys Asp Ser Ile Gln Thr Ser Ile 
        195                 200                 205             


Ile Asn Arg Thr Ser Val Gly Ser Leu Gln Gly Leu Ala Val Asp Met 
    210                 215                 220                 


Asp Ser Val Val Leu Asn Ala Gly Leu Arg Ser Asp Tyr Ser Ser Thr 
225                 230                 235                 240 


Ile Gly Ser Asp Lys Gly Cys Ser Gln Tyr Phe Tyr Ala Glu His Leu 
                245                 250                 255     


Ser Leu His Tyr Pro Leu Glu Ile Ser Ala Ala Ser Gly Arg Leu Met 
            260                 265                 270         


Cys His Phe Lys Leu Val Ala Ile Val Gly Tyr Leu Ile Arg Leu Ser 
        275                 280                 285             


Ile Lys Ser Ile Gln Ile Glu Ala Asp Asn Cys Val Thr Asp Ser Leu 
    290                 295                 300                 


Thr Ile Tyr Asp Ser Leu Leu Pro Ile Arg Ser Ser Ile Leu Tyr Arg 
305                 310                 315                 320 


Ile Cys Glu Pro Thr Arg Thr Leu Met Ser Phe Val Ser Thr Asn Asn 
                325                 330                 335     


Leu Met Leu Val Thr Phe Lys Ser Pro His Ile Arg Arg Leu Ser Gly 
            340                 345                 350         


Ile Arg Ala Tyr Phe Glu Val Ile Pro Glu Gln Lys Cys Glu Asn Thr 
        355                 360                 365             


Val Leu Val Lys Asp Ile Thr Gly Phe Glu Gly Lys Ile Ser Ser Pro 
    370                 375                 380                 


Tyr Tyr Pro Ser Tyr Tyr Pro Pro Lys Cys Lys Cys Thr Trp Lys Phe 
385                 390                 395                 400 


Gln Thr Ser Leu Ser Thr Leu Gly Ile Ala Leu Lys Phe Tyr Asn Tyr 
                405                 410                 415     


Ser Ile Thr Lys Lys Ser Met Lys Gly Cys Glu His Gly Trp Trp Glu 
            420                 425                 430         


Ile Asn Glu His Met Tyr Cys Gly Ser Tyr Met Asp His Gln Thr Ile 
        435                 440                 445             


Phe Arg Val Pro Ser Pro Leu Val His Ile Gln Leu Gln Cys Ser Ser 
    450                 455                 460                 


Arg Leu Ser Asp Lys Pro Leu Leu Ala Glu Tyr Gly Ser Tyr Asn Ile 
465                 470                 475                 480 


Ser Gln Pro Cys Pro Val Gly Ser Phe Arg Cys Ser Ser Gly Leu Cys 
                485                 490                 495     


Val Pro Gln Ala Gln Arg Cys Asp Gly Val Asn Asp Cys Phe Asp Glu 
            500                 505                 510         


Ser Asp Glu Leu Phe Cys Val Ser Pro Gln Pro Ala Cys Asn Thr Ser 
        515                 520                 525             


Ser Phe Arg Gln His Gly Pro Leu Ile Cys Asp Gly Phe Arg Asp Cys 
    530                 535                 540                 


Glu Asn Gly Arg Asp Glu Gln Asn Cys Thr Gln Ser Ile Pro Cys Asn 
545                 550                 555                 560 


Asn Arg Thr Phe Lys Cys Gly Asn Asp Ile Cys Phe Arg Lys Gln Asn 
                565                 570                 575     


Ala Lys Cys Asp Gly Thr Val Asp Cys Pro Asp Gly Ser Asp Glu Glu 
            580                 585                 590         


Gly Cys Thr Cys Ser Arg Ser Ser Ser Ala Leu His Arg Ile Ile Gly 
        595                 600                 605             


Gly Thr Asp Thr Leu Glu Gly Gly Trp Pro Trp Gln Val Ser Leu His 
    610                 615                 620                 


Phe Val Gly Ser Ala Tyr Cys Gly Ala Ser Val Ile Ser Arg Glu Trp 
625                 630                 635                 640 


Leu Leu Ser Ala Ala His Cys Phe His Gly Asn Arg Leu Ser Asp Pro 
                645                 650                 655     


Thr Pro Trp Thr Ala His Leu Gly Met Tyr Val Gln Gly Asn Ala Lys 
            660                 665                 670         


Phe Val Ser Pro Val Arg Arg Ile Val Val His Glu Tyr Tyr Asn Ser 
        675                 680                 685             


Gln Thr Phe Asp Tyr Asp Ile Ala Leu Leu Gln Leu Ser Ile Ala Trp 
    690                 695                 700                 


Pro Glu Thr Leu Lys Gln Leu Ile Gln Pro Ile Cys Ile Pro Pro Thr 
705                 710                 715                 720 


Gly Gln Arg Val Arg Ser Gly Glu Lys Cys Trp Val Thr Gly Trp Gly 
                725                 730                 735     


Arg Arg His Glu Ala Asp Asn Lys Gly Ser Leu Val Leu Gln Gln Ala 
            740                 745                 750         


Glu Val Glu Leu Ile Asp Gln Thr Leu Cys Val Ser Thr Tyr Gly Ile 
        755                 760                 765             


Ile Thr Ser Arg Met Leu Cys Ala Gly Ile Met Ser Gly Lys Arg Asp 
    770                 775                 780                 


Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Ser Cys Arg Arg Lys Ser 
785                 790                 795                 800 


Asp Gly Lys Trp Ile Leu Thr Gly Ile Val Ser Trp Gly His Gly Ser 
                805                 810                 815     


Gly Arg Pro Asn Phe Pro Gly Val Tyr Thr Arg Val Ser Asn Phe Val 
            820                 825                 830         


Pro Trp Ile His Lys Tyr Val Pro Ser Leu Leu 
        835                 840             


<210>  4
<211>  811
<212>  PRT
<213>  Mus Musculus

<400>  4

Met Pro Arg Cys Phe Gln Leu Pro Cys Ser Thr Arg Met Pro Thr Thr 
1               5                   10                  15      


Glu Val Pro Gln Ala Ala Asp Gly Gln Gly Asp Ala Gly Asp Gly Glu 
            20                  25                  30          


Glu Ala Ala Glu Pro Glu Gly Lys Phe Lys Pro Pro Lys Asn Thr Lys 
        35                  40                  45              


Arg Lys Asn Arg Asp Tyr Val Arg Phe Thr Pro Leu Leu Leu Val Leu 
    50                  55                  60                  


Ala Ala Leu Val Ser Ala Gly Val Met Leu Trp Tyr Phe Leu Gly Tyr 
65                  70                  75                  80  


Lys Ala Glu Val Thr Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val 
                85                  90                  95      


Leu Asn Arg His Phe Ser Gln Asp Leu Gly Arg Arg Glu Ser Ile Ala 
            100                 105                 110         


Phe Arg Ser Glu Ser Ala Lys Ala Gln Lys Met Leu Gln Glu Leu Val 
        115                 120                 125             


Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser 
    130                 135                 140                 


Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Asp Ile 
145                 150                 155                 160 


Pro Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val Val Arg Glu Leu 
                165                 170                 175     


Leu Val Asp Glu Leu Leu Ser Asn Ser Ser Thr Leu Ala Ser Tyr Lys 
            180                 185                 190         


Thr Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Asn Pro Gly Gln Val Leu Pro Leu Lys Gly Pro Asp Gln 
225                 230                 235                 240 


Gln Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro Glu Asp Leu Met 
                245                 250                 255     


Ile Lys Val Arg Leu Glu Trp Thr Arg Val Asp Cys Arg Asp Arg Val 
            260                 265                 270         


Ala Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ser Val Met Ala Val Val Trp Lys Lys Gly Met His Ser Tyr Tyr 
305                 310                 315                 320 


Asp Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe Gln Asp Cys Gln 
                325                 330                 335     


Val Asn Leu Thr Leu Glu Gly Arg Leu Asp Thr Gln Gly Phe Leu Arg 
            340                 345                 350         


Thr Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Arg Leu Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe Arg Thr Leu Gln 
                405                 410                 415     


Pro Tyr Ala Glu Arg Ile Pro Met Val Ala Ser Asp Gly Val Thr Ile 
            420                 425                 430         


Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Gln Val Tyr 
        435                 440                 445             


Tyr Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys 
    450                 455                 460                 


Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Ile Lys Asp Cys 
465                 470                 475                 480 


Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Met Phe Gln 
                485                 490                 495     


Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg Val Cys Asp Arg 
            500                 505                 510         


Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly 
        515                 520                 525             


Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val 
    530                 535                 540                 


Lys Lys Pro Asn Pro Glu Cys Asp Gly Gln Ser Asp Cys Arg Asp Gly 
545                 550                 555                 560 


Ser Asp Glu Gln His Cys Asp Cys Gly Leu Gln Gly Leu Ser Ser Arg 
                565                 570                 575     


Ile Val Gly Gly Thr Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala 
            580                 585                 590         


Ser Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala 
        595                 600                 605             


Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met 
    610                 615                 620                 


Ala Ser Pro Lys Leu Trp Thr Val Phe Leu Gly Lys Met Arg Gln Asn 
625                 630                 635                 640 


Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Phe Leu 
                645                 650                 655     


His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu 
            660                 665                 670         


Gln Leu Asp His Pro Val Val Tyr Ser Ala Thr Val Arg Pro Val Cys 
        675                 680                 685             


Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln His Cys Trp Ile 
    690                 695                 700                 


Thr Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Val Ser Asn Thr Leu 
705                 710                 715                 720 


Gln Lys Val Asp Val Gln Leu Val Pro Gln Asp Leu Cys Ser Glu Ala 
                725                 730                 735     


Tyr Arg Tyr Gln Val Ser Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys 
            740                 745                 750         


Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Arg Glu Pro Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly 
    770                 775                 780                 


Leu Gly Cys Gly Arg Pro Asn Phe Phe Gly Val Tyr Thr Arg Val Thr 
785                 790                 795                 800 


Arg Val Ile Asn Trp Ile Gln Gln Val Leu Thr 
                805                 810     


<210>  5
<211>  811
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Pro Arg Cys Phe Gln Leu Pro Cys Ser Thr Arg Met Pro Thr Ala 
1               5                   10                  15      


Glu Val Pro Gln Ala Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu 
            20                  25                  30          


Glu Ala Ala Glu Pro Glu Gly Val Phe Lys Ala Pro Arg Asn Ala Lys 
        35                  40                  45              


Arg Lys Asp Arg Asp Tyr Val Arg Phe Thr Pro Leu Leu Leu Val Leu 
    50                  55                  60                  


Ala Ala Leu Ala Ser Ala Gly Val Met Leu Trp Tyr Phe Leu Gly Tyr 
65                  70                  75                  80  


Lys Ala Glu Val Thr Ile Ser Gln Val Tyr Ser Gly Ser Leu Arg Val 
                85                  90                  95      


Leu Asn Arg His Phe Ser Gln Asp Leu Ala Arg Arg Glu Ser Ile Ala 
            100                 105                 110         


Phe Arg Thr Glu Thr Ala Lys Ala Gln Lys Met Phe Gln Glu Leu Val 
        115                 120                 125             


Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Ile Tyr Ala 
    130                 135                 140                 


Phe Gly Glu Gly Pro Leu Ile Cys Phe Phe Trp Phe Ile Leu Asp Ile 
145                 150                 155                 160 


Pro Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val Val Arg Glu Leu 
                165                 170                 175     


Leu Val Gly Glu Leu Leu Ser Asn Ser Ser Ala Leu Ala Ser Tyr Arg 
            180                 185                 190         


Thr Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Asn Pro Gly Gln Val Leu Arg Leu Arg Gly Pro Asp Gln 
225                 230                 235                 240 


Gln Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro Glu Asp Leu Met 
                245                 250                 255     


Leu Lys Val Gln Leu Glu Trp Thr Arg Val Asp Cys Arg Asp Arg Val 
            260                 265                 270         


Ala Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ser Val Met Ala Val Val Trp Lys Lys Gly Leu His Ser Phe Tyr 
305                 310                 315                 320 


Asp Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe Gln Asp Cys Gln 
                325                 330                 335     


Val Asn Leu Thr Leu Glu Gly Arg Leu Asp Pro Gln Gly Phe Leu Arg 
            340                 345                 350         


Thr Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Leu Leu Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe Arg Thr Leu Gln 
                405                 410                 415     


Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Ser Asp Gly Ile Thr Ile 
            420                 425                 430         


Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Gln Val Tyr 
        435                 440                 445             


Tyr Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys 
    450                 455                 460                 


Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Ile Lys Asp Cys 
465                 470                 475                 480 


Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Met Phe Gln 
                485                 490                 495     


Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg Val Cys Asp Arg 
            500                 505                 510         


Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly 
        515                 520                 525             


Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val 
    530                 535                 540                 


Lys Lys Pro Asn Pro Glu Cys Asp Gly Gln Ala Asp Cys Arg Asp Gly 
545                 550                 555                 560 


Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg 
                565                 570                 575     


Ile Val Gly Gly Ala Met Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala 
            580                 585                 590         


Ser Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala 
        595                 600                 605             


Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met 
    610                 615                 620                 


Ala Ser Pro Arg Leu Trp Thr Val Phe Leu Gly Lys Met Arg Gln Asn 
625                 630                 635                 640 


Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Phe Leu 
                645                 650                 655     


His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu 
            660                 665                 670         


Gln Leu Asp His Pro Val Val Tyr Ser Ala Thr Val Arg Pro Val Cys 
        675                 680                 685             


Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln His Cys Trp Ile 
    690                 695                 700                 


Thr Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Gly Ser Ser Thr Leu 
705                 710                 715                 720 


Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Asn Glu Ala 
                725                 730                 735     


Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys 
            740                 745                 750         


Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Lys Glu Pro Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly 
    770                 775                 780                 


Leu Gly Cys Gly Arg Pro Asn Phe Phe Gly Val Tyr Thr Arg Val Thr 
785                 790                 795                 800 


Arg Val Val Asn Trp Ile Gln Gln Val Leu Thr 
                805                 810     


<210>  6
<211>  800
<212>  PRT
<213>  Cynomologus

<400>  6

Met Pro Val Ala Lys Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Glu Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Ala Pro Leu Trp 
        35                  40                  45              


Leu Thr Leu Val Val Leu Thr Ser Val Gly Val Leu Leu Trp Tyr Phe 
    50                  55                  60                  


Leu Gly Tyr Lys Ala Glu Val Thr Val Ser Gln Val Tyr Ser Gly Ser 
65                  70                  75                  80  


Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu 
                85                  90                  95      


Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys 
            100                 105                 110         


Glu Leu Ile Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser 
        115                 120                 125             


Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile 
    130                 135                 140                 


Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu Val Val 
145                 150                 155                 160 


Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala 
                165                 170                 175     


Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val 
            180                 185                 190         


Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu 
        195                 200                 205             


Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu 
    210                 215                 220                 


Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly 
225                 230                 235                 240 


Pro Glu Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu 
                245                 250                 255     


Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys 
            260                 265                 270         


Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val 
        275                 280                 285             


Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly 
    290                 295                 300                 


Leu His Ser Tyr Tyr Asp Pro Phe Met Leu Ser Val Gln Ser Val Val 
305                 310                 315                 320 


Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asp Arg Leu Asp Ser 
                325                 330                 335     


Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Arg 
            340                 345                 350         


Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu 
        355                 360                 365             


Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu 
    370                 375                 380                 


Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly 
385                 390                 395                 400 


Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr 
                405                 410                 415     


Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro 
            420                 425                 430         


Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro 
        435                 440                 445             


Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp 
    450                 455                 460                 


Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys 
465                 470                 475                 480 


Arg Ala Thr Phe Gln Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Leu 
                485                 490                 495     


Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu 
            500                 505                 510         


Arg Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu 
        515                 520                 525             


Asp Gln Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro 
    530                 535                 540                 


Asp Cys Arg Asp Gly Ser Asp Glu Gln His Cys Asp Cys Gly Leu Gln 
545                 550                 555                 560 


Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu 
                565                 570                 575     


Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly 
            580                 585                 590         


Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe 
        595                 600                 605             


Gln Glu Asp Ser Met Ala Ser Pro Ala Leu Trp Thr Val Phe Leu Gly 
    610                 615                 620                 


Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val 
625                 630                 635                 640 


Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr 
                645                 650                 655     


Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser Ala Ala 
            660                 665                 670         


Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly 
        675                 680                 685             


Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro 
    690                 695                 700                 


Thr Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp 
705                 710                 715                 720 


Leu Cys Ser Glu Ala Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys 
                725                 730                 735     


Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly 
            740                 745                 750         


Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly 
        755                 760                 765             


Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val 
    770                 775                 780                 


Tyr Thr Arg Ile Thr Gly Val Ile Gly Trp Ile Gln Gln Val Val Thr 
785                 790                 795                 800 


<210>  7
<211>  252
<212>  PRT
<213>  Mus Musculus

<400>  7

Met Ala Gln Leu Cys Glu Leu Arg Arg Gly Arg Ala Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Ser Leu Leu Leu Ser Gly Ala Gln Val Ala Ser Arg Glu Leu 
            20                  25                  30          


Asp Val His Glu Ser Cys Gly Val Ser Lys Val Val Gly Lys Cys Arg 
        35                  40                  45              


Ala Ser Ile Pro Arg Trp Trp Tyr Asn Ile Thr Asp Gly Ser Cys Gln 
    50                  55                  60                  


Pro Phe Val Tyr Gly Gly Cys Glu Gly Asn Gly Asn Asn Tyr Gln Ser 
65                  70                  75                  80  


Lys Glu Glu Cys Leu Asp Lys Cys Ala Gly Val Thr Glu Asn Thr Thr 
                85                  90                  95      


Asp Asp Met Ala Arg Asn Arg Asn Gly Ala Asp Ser Ser Val Leu Ser 
            100                 105                 110         


Val Pro Arg Lys Gln Ser Ala Glu Asp Leu Ser Ala Glu Ile Phe Asn 
        115                 120                 125             


Tyr Glu Glu Tyr Cys Val Pro Lys Ala Val Thr Gly Pro Cys Arg Ala 
    130                 135                 140                 


Ala Phe Pro Arg Trp Tyr Tyr Asp Thr Glu Lys Asn Ser Cys Ile Ser 
145                 150                 155                 160 


Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn Ser Tyr Leu Ser Gln 
                165                 170                 175     


Glu Ala Cys Met Gln His Cys Ser Gly Lys Gln Met His Pro Phe Leu 
            180                 185                 190         


Thr Pro Gly Leu Lys Ala Val Ile Leu Val Gly Leu Phe Leu Met Val 
        195                 200                 205             


Leu Ile Leu Leu Leu Gly Thr Ser Met Val Cys Leu Ile Arg Val Val 
    210                 215                 220                 


Arg Arg Lys Gln Glu Arg Ala Leu Arg Thr Val Trp Ser Thr Ala Asp 
225                 230                 235                 240 


Asp Lys Glu Gln Leu Val Lys Asn Thr Cys Val Leu 
                245                 250         


<210>  8
<211>  754
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg 
1               5                   10                  15      


Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser 
            20                  25                  30          


Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu 
        35                  40                  45              


Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr 
    50                  55                  60                  


Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln 
65                  70                  75                  80  


Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala 
                85                  90                  95      


Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val 
            100                 105                 110         


Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu 
        115                 120                 125             


Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys 
    130                 135                 140                 


Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly 
145                 150                 155                 160 


Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys 
                165                 170                 175     


Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg 
            180                 185                 190         


Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu 
        195                 200                 205             


Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val 
    210                 215                 220                 


Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His 
225                 230                 235                 240 


Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln 
                245                 250                 255     


Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly 
            260                 265                 270         


Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His 
        275                 280                 285             


Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu 
    290                 295                 300                 


Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys 
305                 310                 315                 320 


Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg 
                325                 330                 335     


Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly 
            340                 345                 350         


Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val 
        355                 360                 365             


Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu 
    370                 375                 380                 


Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val 
385                 390                 395                 400 


Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala 
                405                 410                 415     


Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val 
            420                 425                 430         


Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys 
        435                 440                 445             


Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg 
    450                 455                 460                 


Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys 
465                 470                 475                 480 


Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro 
                485                 490                 495     


Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro 
            500                 505                 510         


Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala 
        515                 520                 525             


Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu 
    530                 535                 540                 


Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val 
545                 550                 555                 560 


Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg 
                565                 570                 575     


Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val 
            580                 585                 590         


Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg 
        595                 600                 605             


Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His 
    610                 615                 620                 


Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser 
625                 630                 635                 640 


Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys 
                645                 650                 655     


Ser Glu Val Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly 
            660                 665                 670         


Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
        675                 680                 685             


Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val 
    690                 695                 700                 


Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr 
705                 710                 715                 720 


Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr Gly Lys 
                725                 730                 735     


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His 
            740                 745                 750         


His His 
        


<210>  9
<211>  1058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human matriptase-2 antigen eGFP/flag tag

<400>  9

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Met 
225                 230                 235                 240 


Leu Leu Leu Phe His Ser Lys Arg Met Pro Val Ala Glu Ala Pro Gln 
                245                 250                 255     


Val Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu Glu Ala Glu Pro 
            260                 265                 270         


Glu Gly Met Phe Lys Ala Cys Glu Asp Ser Lys Arg Lys Ala Arg Gly 
        275                 280                 285             


Tyr Leu Arg Leu Val Pro Leu Phe Val Leu Leu Ala Leu Leu Val Leu 
    290                 295                 300                 


Ala Ser Ala Gly Val Leu Leu Trp Tyr Phe Leu Gly Tyr Lys Ala Glu 
305                 310                 315                 320 


Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn Arg 
                325                 330                 335     


His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg Ser 
            340                 345                 350         


Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Thr Ser Thr 
        355                 360                 365             


Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly Glu 
    370                 375                 380                 


Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu His 
385                 390                 395                 400 


Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val Glu 
                405                 410                 415     


Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg Ala 
            420                 425                 430         


Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser Val 
        435                 440                 445             


Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr Ser 
    450                 455                 460                 


Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His Leu 
465                 470                 475                 480 


Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met Leu 
                485                 490                 495     


Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu Ala 
            500                 505                 510         


Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser Val 
        515                 520                 525             


Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser Gly 
    530                 535                 540                 


Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr Asp 
545                 550                 555                 560 


Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu Val 
                565                 570                 575     


Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser Thr 
            580                 585                 590         


Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp His 
        595                 600                 605             


Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp Ala 
    610                 615                 620                 


Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly Gln 
625                 630                 635                 640 


Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln Pro 
                645                 650                 655     


Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile Asn 
            660                 665                 670         


Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His Tyr 
        675                 680                 685             


Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys Ser 
    690                 695                 700                 


Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys Pro 
705                 710                 715                 720 


Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln Cys 
                725                 730                 735     


Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly Gln 
            740                 745                 750         


Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly Val 
        755                 760                 765             


Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val Lys 
    770                 775                 780                 


Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly Ser 
785                 790                 795                 800 


Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg Ile 
                805                 810                 815     


Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala Ser 
            820                 825                 830         


Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala Asp 
        835                 840                 845             


Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met Ala 
    850                 855                 860                 


Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn Ser 
865                 870                 875                 880 


Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu His 
                885                 890                 895     


Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu Gln 
            900                 905                 910         


Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys Leu 
        915                 920                 925             


Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile Thr 
    930                 935                 940                 


Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu Gln 
945                 950                 955                 960 


Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val Tyr 
                965                 970                 975     


Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly 
            980                 985                 990         


Lys Lys Asp Ala Cys Gln Gly Asp  Ser Gly Gly Pro Leu  Val Cys Lys 
        995                 1000                 1005             


Ala Leu  Ser Gly Arg Trp Phe  Leu Ala Gly Leu Val  Ser Trp Gly 
    1010                 1015                 1020             


Leu Gly  Cys Gly Arg Pro Asn  Tyr Phe Gly Val Tyr  Thr Arg Ile 
    1025                 1030                 1035             


Thr Gly  Val Ile Ser Trp Ile  Gln Gln Val Val Thr  Asp Tyr Lys 
    1040                 1045                 1050             


Asp Asp  Asp Asp Lys 
    1055             


<210>  10
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Gly Pro Ile Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro 
705                 710                 715                 720 


Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr Gln Val Thr Pro Arg Met 
                725                 730                 735     


Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp 
            740                 745                 750         


Ser Gly Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu 
        755                 760                 765             


Ala Gly Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe 
    770                 775                 780                 


Gly Val Tyr Thr Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val 
785                 790                 795                 800 


Val Thr 
        


<210>  11
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Glu Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Gly Pro Ile Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro 
705                 710                 715                 720 


Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr Gln Val Thr Pro Arg Met 
                725                 730                 735     


Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp 
            740                 745                 750         


Ser Gly Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu 
        755                 760                 765             


Ala Gly Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe 
    770                 775                 780                 


Gly Val Tyr Thr Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val 
785                 790                 795                 800 


Val Thr 
        


<210>  12
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Gly Pro Ile Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro 
705                 710                 715                 720 


Gln Asp Leu Cys Ser Glu Ala Tyr Arg Tyr Gln Val Thr Pro Arg Met 
                725                 730                 735     


Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp 
            740                 745                 750         


Ser Gly Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu 
        755                 760                 765             


Ala Gly Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe 
    770                 775                 780                 


Gly Val Tyr Thr Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val 
785                 790                 795                 800 


Val Thr 
        


<210>  13
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Glu Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Gly Pro Ile Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro 
705                 710                 715                 720 


Gln Asp Leu Cys Ser Glu Ala Tyr Arg Tyr Gln Val Thr Pro Arg Met 
                725                 730                 735     


Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp 
            740                 745                 750         


Ser Gly Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu 
        755                 760                 765             


Ala Gly Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe 
    770                 775                 780                 


Gly Val Tyr Thr Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val 
785                 790                 795                 800 


Val Thr 
        


<210>  14
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human matriptase-1 antigen his tag

<400>  14

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val Gly Gly Gly Gly Ser His His His His 
    850                 855                 860                 


His His 
865     


<210>  15
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human matriptase-3 antigen his tag

<400>  15

Met Asp Lys Glu Asn Ser Asp Val Ser Ala Ala Pro Ala Asp Leu Lys 
1               5                   10                  15      


Ile Ser Asn Ile Ser Val Gln Val Val Ser Ala Gln Lys Lys Leu Pro 
            20                  25                  30          


Val Arg Arg Pro Pro Leu Pro Gly Arg Arg Leu Pro Leu Pro Gly Arg 
        35                  40                  45              


Arg Pro Pro Gln Arg Pro Ile Gly Lys Ala Lys Pro Lys Lys Gln Ser 
    50                  55                  60                  


Lys Lys Lys Val Pro Phe Trp Asn Val Gln Asn Lys Ile Ile Leu Phe 
65                  70                  75                  80  


Thr Val Phe Leu Phe Ile Leu Ala Val Ile Ala Trp Thr Leu Leu Trp 
                85                  90                  95      


Leu Tyr Ile Ser Lys Thr Glu Ser Lys Asp Ala Phe Tyr Phe Ala Gly 
            100                 105                 110         


Met Phe Arg Ile Thr Asn Ile Glu Phe Leu Pro Glu Tyr Arg Gln Lys 
        115                 120                 125             


Glu Ser Arg Glu Phe Leu Ser Val Ser Arg Thr Val Gln Gln Val Ile 
    130                 135                 140                 


Asn Leu Val Tyr Thr Thr Ser Ala Phe Ser Lys Phe Tyr Glu Gln Ser 
145                 150                 155                 160 


Val Val Ala Asp Val Ser Ser Asn Asn Lys Gly Gly Leu Leu Val His 
                165                 170                 175     


Phe Trp Ile Val Phe Val Met Pro Arg Ala Lys Gly His Ile Phe Cys 
            180                 185                 190         


Glu Asp Cys Val Ala Ala Ile Leu Lys Asp Ser Ile Gln Thr Ser Ile 
        195                 200                 205             


Ile Asn Arg Thr Ser Val Gly Ser Leu Gln Gly Leu Ala Val Asp Met 
    210                 215                 220                 


Asp Ser Val Val Leu Asn Ala Gly Leu Arg Ser Asp Tyr Ser Ser Thr 
225                 230                 235                 240 


Ile Gly Ser Asp Lys Gly Cys Ser Gln Tyr Phe Tyr Ala Glu His Leu 
                245                 250                 255     


Ser Leu His Tyr Pro Leu Glu Ile Ser Ala Ala Ser Gly Arg Leu Met 
            260                 265                 270         


Cys His Phe Lys Leu Val Ala Ile Val Gly Tyr Leu Ile Arg Leu Ser 
        275                 280                 285             


Ile Lys Ser Ile Gln Ile Glu Ala Asp Asn Cys Val Thr Asp Ser Leu 
    290                 295                 300                 


Thr Ile Tyr Asp Ser Leu Leu Pro Ile Arg Ser Ser Ile Leu Tyr Arg 
305                 310                 315                 320 


Ile Cys Glu Pro Thr Arg Thr Leu Met Ser Phe Val Ser Thr Asn Asn 
                325                 330                 335     


Leu Met Leu Val Thr Phe Lys Ser Pro His Ile Arg Arg Leu Ser Gly 
            340                 345                 350         


Ile Arg Ala Tyr Phe Glu Val Ile Pro Glu Gln Lys Cys Glu Asn Thr 
        355                 360                 365             


Val Leu Val Lys Asp Ile Thr Gly Phe Glu Gly Lys Ile Ser Ser Pro 
    370                 375                 380                 


Tyr Tyr Pro Ser Tyr Tyr Pro Pro Lys Cys Lys Cys Thr Trp Lys Phe 
385                 390                 395                 400 


Gln Thr Ser Leu Ser Thr Leu Gly Ile Ala Leu Lys Phe Tyr Asn Tyr 
                405                 410                 415     


Ser Ile Thr Lys Lys Ser Met Lys Gly Cys Glu His Gly Trp Trp Glu 
            420                 425                 430         


Ile Asn Glu His Met Tyr Cys Gly Ser Tyr Met Asp His Gln Thr Ile 
        435                 440                 445             


Phe Arg Val Pro Ser Pro Leu Val His Ile Gln Leu Gln Cys Ser Ser 
    450                 455                 460                 


Arg Leu Ser Asp Lys Pro Leu Leu Ala Glu Tyr Gly Ser Tyr Asn Ile 
465                 470                 475                 480 


Ser Gln Pro Cys Pro Val Gly Ser Phe Arg Cys Ser Ser Gly Leu Cys 
                485                 490                 495     


Val Pro Gln Ala Gln Arg Cys Asp Gly Val Asn Asp Cys Phe Asp Glu 
            500                 505                 510         


Ser Asp Glu Leu Phe Cys Val Ser Pro Gln Pro Ala Cys Asn Thr Ser 
        515                 520                 525             


Ser Phe Arg Gln His Gly Pro Leu Ile Cys Asp Gly Phe Arg Asp Cys 
    530                 535                 540                 


Glu Asn Gly Arg Asp Glu Gln Asn Cys Thr Gln Ser Ile Pro Cys Asn 
545                 550                 555                 560 


Asn Arg Thr Phe Lys Cys Gly Asn Asp Ile Cys Phe Arg Lys Gln Asn 
                565                 570                 575     


Ala Lys Cys Asp Gly Thr Val Asp Cys Pro Asp Gly Ser Asp Glu Glu 
            580                 585                 590         


Gly Cys Thr Cys Ser Arg Ser Ser Ser Ala Leu His Arg Ile Ile Gly 
        595                 600                 605             


Gly Thr Asp Thr Leu Glu Gly Gly Trp Pro Trp Gln Val Ser Leu His 
    610                 615                 620                 


Phe Val Gly Ser Ala Tyr Cys Gly Ala Ser Val Ile Ser Arg Glu Trp 
625                 630                 635                 640 


Leu Leu Ser Ala Ala His Cys Phe His Gly Asn Arg Leu Ser Asp Pro 
                645                 650                 655     


Thr Pro Trp Thr Ala His Leu Gly Met Tyr Val Gln Gly Asn Ala Lys 
            660                 665                 670         


Phe Val Ser Pro Val Arg Arg Ile Val Val His Glu Tyr Tyr Asn Ser 
        675                 680                 685             


Gln Thr Phe Asp Tyr Asp Ile Ala Leu Leu Gln Leu Ser Ile Ala Trp 
    690                 695                 700                 


Pro Glu Thr Leu Lys Gln Leu Ile Gln Pro Ile Cys Ile Pro Pro Thr 
705                 710                 715                 720 


Gly Gln Arg Val Arg Ser Gly Glu Lys Cys Trp Val Thr Gly Trp Gly 
                725                 730                 735     


Arg Arg His Glu Ala Asp Asn Lys Gly Ser Leu Val Leu Gln Gln Ala 
            740                 745                 750         


Glu Val Glu Leu Ile Asp Gln Thr Leu Cys Val Ser Thr Tyr Gly Ile 
        755                 760                 765             


Ile Thr Ser Arg Met Leu Cys Ala Gly Ile Met Ser Gly Lys Arg Asp 
    770                 775                 780                 


Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Ser Cys Arg Arg Lys Ser 
785                 790                 795                 800 


Asp Gly Lys Trp Ile Leu Thr Gly Ile Val Ser Trp Gly His Gly Ser 
                805                 810                 815     


Gly Arg Pro Asn Phe Pro Gly Val Tyr Thr Arg Val Ser Asn Phe Val 
            820                 825                 830         


Pro Trp Ile His Lys Tyr Val Pro Ser Leu Leu Gly Gly Gly Gly Ser 
        835                 840                 845             


His His His His His His 
    850                 


<210>  16
<211>  1058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse matriptase-2 antigen eGFP/flag tag

<400>  16

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Met 
225                 230                 235                 240 


Pro Arg Cys Phe Gln Leu Pro Cys Ser Thr Arg Met Pro Thr Thr Glu 
                245                 250                 255     


Val Pro Gln Ala Ala Asp Gly Gln Gly Asp Ala Gly Asp Gly Glu Glu 
            260                 265                 270         


Ala Ala Glu Pro Glu Gly Lys Phe Lys Pro Pro Lys Asn Thr Lys Arg 
        275                 280                 285             


Lys Asn Arg Asp Tyr Val Arg Phe Thr Pro Leu Leu Leu Val Leu Ala 
    290                 295                 300                 


Ala Leu Val Ser Ala Gly Val Met Leu Trp Tyr Phe Leu Gly Tyr Lys 
305                 310                 315                 320 


Ala Glu Val Thr Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu 
                325                 330                 335     


Asn Arg His Phe Ser Gln Asp Leu Gly Arg Arg Glu Ser Ile Ala Phe 
            340                 345                 350         


Arg Ser Glu Ser Ala Lys Ala Gln Lys Met Leu Gln Glu Leu Val Ala 
        355                 360                 365             


Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe 
    370                 375                 380                 


Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Asp Ile Pro 
385                 390                 395                 400 


Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val Val Arg Glu Leu Leu 
                405                 410                 415     


Val Asp Glu Leu Leu Ser Asn Ser Ser Thr Leu Ala Ser Tyr Lys Thr 
            420                 425                 430         


Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser Val 
        435                 440                 445             


Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr Ser 
    450                 455                 460                 


Tyr Val Asn Pro Gly Gln Val Leu Pro Leu Lys Gly Pro Asp Gln Gln 
465                 470                 475                 480 


Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro Glu Asp Leu Met Ile 
                485                 490                 495     


Lys Val Arg Leu Glu Trp Thr Arg Val Asp Cys Arg Asp Arg Val Ala 
            500                 505                 510         


Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser Val 
        515                 520                 525             


Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu Val Leu Ala Ser Gly 
    530                 535                 540                 


Ser Val Met Ala Val Val Trp Lys Lys Gly Met His Ser Tyr Tyr Asp 
545                 550                 555                 560 


Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe Gln Asp Cys Gln Val 
                565                 570                 575     


Asn Leu Thr Leu Glu Gly Arg Leu Asp Thr Gln Gly Phe Leu Arg Thr 
            580                 585                 590         


Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr His Cys Ser Trp His 
        595                 600                 605             


Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp Ala 
    610                 615                 620                 


Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Arg Leu Cys Thr Gln Gly Gln 
625                 630                 635                 640 


Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe Arg Thr Leu Gln Pro 
                645                 650                 655     


Tyr Ala Glu Arg Ile Pro Met Val Ala Ser Asp Gly Val Thr Ile Asn 
            660                 665                 670         


Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Gln Val Tyr Tyr 
        675                 680                 685             


Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys Ser 
    690                 695                 700                 


Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Ile Lys Asp Cys Pro 
705                 710                 715                 720 


Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Met Phe Gln Cys 
                725                 730                 735     


Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg Val Cys Asp Arg Gln 
            740                 745                 750         


Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly Val 
        755                 760                 765             


Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val Lys 
    770                 775                 780                 


Lys Pro Asn Pro Glu Cys Asp Gly Gln Ser Asp Cys Arg Asp Gly Ser 
785                 790                 795                 800 


Asp Glu Gln His Cys Asp Cys Gly Leu Gln Gly Leu Ser Ser Arg Ile 
                805                 810                 815     


Val Gly Gly Thr Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala Ser 
            820                 825                 830         


Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala Asp 
        835                 840                 845             


Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met Ala 
    850                 855                 860                 


Ser Pro Lys Leu Trp Thr Val Phe Leu Gly Lys Met Arg Gln Asn Ser 
865                 870                 875                 880 


Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Phe Leu His 
                885                 890                 895     


Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu Gln 
            900                 905                 910         


Leu Asp His Pro Val Val Tyr Ser Ala Thr Val Arg Pro Val Cys Leu 
        915                 920                 925             


Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln His Cys Trp Ile Thr 
    930                 935                 940                 


Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Val Ser Asn Thr Leu Gln 
945                 950                 955                 960 


Lys Val Asp Val Gln Leu Val Pro Gln Asp Leu Cys Ser Glu Ala Tyr 
                965                 970                 975     


Arg Tyr Gln Val Ser Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly 
            980                 985                 990         


Lys Lys Asp Ala Cys Gln Gly Asp  Ser Gly Gly Pro Leu  Val Cys Arg 
        995                 1000                 1005             


Glu Pro  Ser Gly Arg Trp Phe  Leu Ala Gly Leu Val  Ser Trp Gly 
    1010                 1015                 1020             


Leu Gly  Cys Gly Arg Pro Asn  Phe Phe Gly Val Tyr  Thr Arg Val 
    1025                 1030                 1035             


Thr Arg  Val Ile Asn Trp Ile  Gln Gln Val Leu Thr  Asp Tyr Lys 
    1040                 1045                 1050             


Asp Asp  Asp Asp Lys 
    1055             


<210>  17
<211>  799
<212>  PRT
<213>  Mus Musculus

<400>  17

Met Pro Thr Thr Glu Val Pro Gln Ala Ala Asp Gly Gln Gly Asp Ala 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Ala Glu Pro Glu Gly Lys Phe Lys Pro Pro 
            20                  25                  30          


Lys Asn Thr Lys Arg Lys Asn Arg Asp Tyr Val Arg Phe Thr Pro Leu 
        35                  40                  45              


Leu Leu Val Leu Ala Ala Leu Val Ser Ala Gly Val Met Leu Trp Tyr 
    50                  55                  60                  


Phe Leu Gly Tyr Lys Ala Glu Val Thr Val Ser Gln Val Tyr Ser Gly 
65                  70                  75                  80  


Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Gly Arg Arg 
                85                  90                  95      


Glu Ser Ile Ala Phe Arg Ser Glu Ser Ala Lys Ala Gln Lys Met Leu 
            100                 105                 110         


Gln Glu Leu Val Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser 
        115                 120                 125             


Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe 
    130                 135                 140                 


Ile Leu Asp Ile Pro Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val 
145                 150                 155                 160 


Val Arg Glu Leu Leu Val Asp Glu Leu Leu Ser Asn Ser Ser Thr Leu 
                165                 170                 175     


Ala Ser Tyr Lys Thr Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile 
            180                 185                 190         


Leu Glu Ala Ser Val Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly 
        195                 200                 205             


Cys Tyr Arg Tyr Ser Tyr Val Asn Pro Gly Gln Val Leu Pro Leu Lys 
    210                 215                 220                 


Gly Pro Asp Gln Gln Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro 
225                 230                 235                 240 


Glu Asp Leu Met Ile Lys Val Arg Leu Glu Trp Thr Arg Val Asp Cys 
                245                 250                 255     


Arg Asp Arg Val Ala Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg 
            260                 265                 270         


Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu 
        275                 280                 285             


Val Leu Ala Ser Gly Ser Val Met Ala Val Val Trp Lys Lys Gly Met 
    290                 295                 300                 


His Ser Tyr Tyr Asp Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe 
305                 310                 315                 320 


Gln Asp Cys Gln Val Asn Leu Thr Leu Glu Gly Arg Leu Asp Thr Gln 
                325                 330                 335     


Gly Phe Leu Arg Thr Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr 
            340                 345                 350         


His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala 
        355                 360                 365             


Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Arg Leu 
    370                 375                 380                 


Cys Thr Gln Gly Gln Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe 
385                 390                 395                 400 


Arg Thr Leu Gln Pro Tyr Ala Glu Arg Ile Pro Met Val Ala Ser Asp 
                405                 410                 415     


Gly Val Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly 
            420                 425                 430         


Val Gln Val Tyr Tyr Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly 
        435                 440                 445             


Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly 
    450                 455                 460                 


Ile Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg 
465                 470                 475                 480 


Ala Met Phe Gln Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg 
                485                 490                 495     


Val Cys Asp Arg Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln 
            500                 505                 510         


Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp 
        515                 520                 525             


Arg Ser Cys Val Lys Lys Pro Asn Pro Glu Cys Asp Gly Gln Ser Asp 
    530                 535                 540                 


Cys Arg Asp Gly Ser Asp Glu Gln His Cys Asp Cys Gly Leu Gln Gly 
545                 550                 555                 560 


Leu Ser Ser Arg Ile Val Gly Gly Thr Val Ser Ser Glu Gly Glu Trp 
                565                 570                 575     


Pro Trp Gln Ala Ser Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly 
            580                 585                 590         


Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln 
        595                 600                 605             


Glu Asp Ser Met Ala Ser Pro Lys Leu Trp Thr Val Phe Leu Gly Lys 
    610                 615                 620                 


Met Arg Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser 
625                 630                 635                 640 


Arg Leu Phe Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp 
                645                 650                 655     


Val Ala Leu Leu Gln Leu Asp His Pro Val Val Tyr Ser Ala Thr Val 
            660                 665                 670         


Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln 
        675                 680                 685             


His Cys Trp Ile Thr Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Val 
    690                 695                 700                 


Ser Asn Thr Leu Gln Lys Val Asp Val Gln Leu Val Pro Gln Asp Leu 
705                 710                 715                 720 


Cys Ser Glu Ala Tyr Arg Tyr Gln Val Ser Pro Arg Met Leu Cys Ala 
                725                 730                 735     


Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
            740                 745                 750         


Pro Leu Val Cys Arg Glu Pro Ser Gly Arg Trp Phe Leu Ala Gly Leu 
        755                 760                 765             


Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Phe Phe Gly Val Tyr 
    770                 775                 780                 


Thr Arg Val Thr Arg Val Ile Asn Trp Ile Gln Gln Val Leu Thr 
785                 790                 795                 


<210>  18
<211>  799
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Pro Thr Ala Glu Val Pro Gln Ala Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Ala Glu Pro Glu Gly Val Phe Lys Ala Pro 
            20                  25                  30          


Arg Asn Ala Lys Arg Lys Asp Arg Asp Tyr Val Arg Phe Thr Pro Leu 
        35                  40                  45              


Leu Leu Val Leu Ala Ala Leu Ala Ser Ala Gly Val Met Leu Trp Tyr 
    50                  55                  60                  


Phe Leu Gly Tyr Lys Ala Glu Val Thr Ile Ser Gln Val Tyr Ser Gly 
65                  70                  75                  80  


Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Ala Arg Arg 
                85                  90                  95      


Glu Ser Ile Ala Phe Arg Thr Glu Thr Ala Lys Ala Gln Lys Met Phe 
            100                 105                 110         


Gln Glu Leu Val Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser 
        115                 120                 125             


Ser Ile Tyr Ala Phe Gly Glu Gly Pro Leu Ile Cys Phe Phe Trp Phe 
    130                 135                 140                 


Ile Leu Asp Ile Pro Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val 
145                 150                 155                 160 


Val Arg Glu Leu Leu Val Gly Glu Leu Leu Ser Asn Ser Ser Ala Leu 
                165                 170                 175     


Ala Ser Tyr Arg Thr Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile 
            180                 185                 190         


Leu Glu Ala Ser Val Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly 
        195                 200                 205             


Cys Tyr Arg Tyr Ser Tyr Val Asn Pro Gly Gln Val Leu Arg Leu Arg 
    210                 215                 220                 


Gly Pro Asp Gln Gln Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro 
225                 230                 235                 240 


Glu Asp Leu Met Leu Lys Val Gln Leu Glu Trp Thr Arg Val Asp Cys 
                245                 250                 255     


Arg Asp Arg Val Ala Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg 
            260                 265                 270         


Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu 
        275                 280                 285             


Val Leu Ala Ser Gly Ser Val Met Ala Val Val Trp Lys Lys Gly Leu 
    290                 295                 300                 


His Ser Phe Tyr Asp Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe 
305                 310                 315                 320 


Gln Asp Cys Gln Val Asn Leu Thr Leu Glu Gly Arg Leu Asp Pro Gln 
                325                 330                 335     


Gly Phe Leu Arg Thr Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr 
            340                 345                 350         


His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala 
        355                 360                 365             


Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Leu Leu 
    370                 375                 380                 


Cys Thr Gln Gly Gln Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe 
385                 390                 395                 400 


Arg Thr Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Ser Asp 
                405                 410                 415     


Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly 
            420                 425                 430         


Val Gln Val Tyr Tyr Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly 
        435                 440                 445             


Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly 
    450                 455                 460                 


Ile Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg 
465                 470                 475                 480 


Ala Met Phe Gln Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg 
                485                 490                 495     


Val Cys Asp Arg Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln 
            500                 505                 510         


Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp 
        515                 520                 525             


Arg Ser Cys Val Lys Lys Pro Asn Pro Glu Cys Asp Gly Gln Ala Asp 
    530                 535                 540                 


Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly 
545                 550                 555                 560 


Pro Ser Ser Arg Ile Val Gly Gly Ala Met Ser Ser Glu Gly Glu Trp 
                565                 570                 575     


Pro Trp Gln Ala Ser Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly 
            580                 585                 590         


Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln 
        595                 600                 605             


Glu Asp Ser Met Ala Ser Pro Arg Leu Trp Thr Val Phe Leu Gly Lys 
    610                 615                 620                 


Met Arg Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser 
625                 630                 635                 640 


Arg Leu Phe Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp 
                645                 650                 655     


Val Ala Leu Leu Gln Leu Asp His Pro Val Val Tyr Ser Ala Thr Val 
            660                 665                 670         


Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln 
        675                 680                 685             


His Cys Trp Ile Thr Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Gly 
    690                 695                 700                 


Ser Ser Thr Leu Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu 
705                 710                 715                 720 


Cys Asn Glu Ala Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala 
                725                 730                 735     


Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
            740                 745                 750         


Pro Leu Val Cys Lys Glu Pro Ser Gly Arg Trp Phe Leu Ala Gly Leu 
        755                 760                 765             


Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Phe Phe Gly Val Tyr 
    770                 775                 780                 


Thr Arg Val Thr Arg Val Val Asn Trp Ile Gln Gln Val Leu Thr 
785                 790                 795                 


<210>  19
<211>  800
<212>  PRT
<213>  Cynomologus

<400>  19

Met Pro Val Ala Lys Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Glu Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Ala Pro Leu Trp 
        35                  40                  45              


Leu Thr Leu Val Val Leu Thr Ser Val Gly Val Leu Leu Trp Tyr Phe 
    50                  55                  60                  


Leu Gly Tyr Lys Ala Glu Val Thr Val Ser Gln Val Tyr Ser Gly Ser 
65                  70                  75                  80  


Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu 
                85                  90                  95      


Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys 
            100                 105                 110         


Glu Leu Ile Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser 
        115                 120                 125             


Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile 
    130                 135                 140                 


Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu Val Val 
145                 150                 155                 160 


Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala 
                165                 170                 175     


Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val 
            180                 185                 190         


Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu 
        195                 200                 205             


Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu 
    210                 215                 220                 


Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly 
225                 230                 235                 240 


Pro Glu Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu 
                245                 250                 255     


Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys 
            260                 265                 270         


Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val 
        275                 280                 285             


Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly 
    290                 295                 300                 


Leu His Ser Tyr Tyr Asp Pro Phe Met Leu Ser Val Gln Ser Val Val 
305                 310                 315                 320 


Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asp Arg Leu Asp Ser 
                325                 330                 335     


Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Arg 
            340                 345                 350         


Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu 
        355                 360                 365             


Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu 
    370                 375                 380                 


Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly 
385                 390                 395                 400 


Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr 
                405                 410                 415     


Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro 
            420                 425                 430         


Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro 
        435                 440                 445             


Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp 
    450                 455                 460                 


Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys 
465                 470                 475                 480 


Arg Ala Thr Phe Gln Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Leu 
                485                 490                 495     


Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu 
            500                 505                 510         


Arg Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu 
        515                 520                 525             


Asp Gln Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro 
    530                 535                 540                 


Asp Cys Arg Asp Gly Ser Asp Glu Gln His Cys Asp Cys Gly Leu Gln 
545                 550                 555                 560 


Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu 
                565                 570                 575     


Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly 
            580                 585                 590         


Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe 
        595                 600                 605             


Gln Glu Asp Ser Met Ala Ser Pro Ala Leu Trp Thr Val Phe Leu Gly 
    610                 615                 620                 


Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val 
625                 630                 635                 640 


Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr 
                645                 650                 655     


Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser Ala Ala 
            660                 665                 670         


Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly 
        675                 680                 685             


Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro 
    690                 695                 700                 


Thr Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp 
705                 710                 715                 720 


Leu Cys Ser Glu Ala Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys 
                725                 730                 735     


Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly 
            740                 745                 750         


Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly 
        755                 760                 765             


Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val 
    770                 775                 780                 


Tyr Thr Arg Ile Thr Gly Val Ile Gly Trp Ile Gln Gln Val Val Thr 
785                 790                 795                 800 


<210>  20
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human matriptase-2 ECD protein his tag

<400>  20

Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg 
1               5                   10                  15      


Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser 
            20                  25                  30          


Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu 
        35                  40                  45              


Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr 
    50                  55                  60                  


Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln 
65                  70                  75                  80  


Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala 
                85                  90                  95      


Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val 
            100                 105                 110         


Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu 
        115                 120                 125             


Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys 
    130                 135                 140                 


Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly 
145                 150                 155                 160 


Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys 
                165                 170                 175     


Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg 
            180                 185                 190         


Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu 
        195                 200                 205             


Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val 
    210                 215                 220                 


Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His 
225                 230                 235                 240 


Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln 
                245                 250                 255     


Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly 
            260                 265                 270         


Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His 
        275                 280                 285             


Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu 
    290                 295                 300                 


Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys 
305                 310                 315                 320 


Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg 
                325                 330                 335     


Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly 
            340                 345                 350         


Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val 
        355                 360                 365             


Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu 
    370                 375                 380                 


Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val 
385                 390                 395                 400 


Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala 
                405                 410                 415     


Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val 
            420                 425                 430         


Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys 
        435                 440                 445             


Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg 
    450                 455                 460                 


Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys 
465                 470                 475                 480 


Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro 
                485                 490                 495     


Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro 
            500                 505                 510         


Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala 
        515                 520                 525             


Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu 
    530                 535                 540                 


Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val 
545                 550                 555                 560 


Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg 
                565                 570                 575     


Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val 
            580                 585                 590         


Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg 
        595                 600                 605             


Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His 
    610                 615                 620                 


Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser 
625                 630                 635                 640 


Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys 
                645                 650                 655     


Ser Glu Val Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly 
            660                 665                 670         


Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
        675                 680                 685             


Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val 
    690                 695                 700                 


Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr 
705                 710                 715                 720 


Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr Gly Gly 
                725                 730                 735     


Gly Gly Ser Gly Gly Gly Gly Ser His His His His His His Gly Ser 
            740                 745                 750         


His His His His 
        755     


<210>  21
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human matriptase-2 mask ECD protein his tag

<400>  21

Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg 
1               5                   10                  15      


Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser 
            20                  25                  30          


Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu 
        35                  40                  45              


Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr 
    50                  55                  60                  


Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln 
65                  70                  75                  80  


Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala 
                85                  90                  95      


Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val 
            100                 105                 110         


Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu 
        115                 120                 125             


Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys 
    130                 135                 140                 


Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly 
145                 150                 155                 160 


Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys 
                165                 170                 175     


Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg 
            180                 185                 190         


Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu 
        195                 200                 205             


Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val 
    210                 215                 220                 


Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His 
225                 230                 235                 240 


Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln 
                245                 250                 255     


Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly 
            260                 265                 270         


Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His 
        275                 280                 285             


Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu 
    290                 295                 300                 


Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys 
305                 310                 315                 320 


Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg 
                325                 330                 335     


Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly 
            340                 345                 350         


Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val 
        355                 360                 365             


Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu 
    370                 375                 380                 


Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val 
385                 390                 395                 400 


Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala 
                405                 410                 415     


Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val 
            420                 425                 430         


Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys 
        435                 440                 445             


Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg 
    450                 455                 460                 


Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys 
465                 470                 475                 480 


Arg Asp Gly Ser Asp Glu Glu His Cys Asp Ser Gly Leu Gln Gly Pro 
                485                 490                 495     


Ser Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His His His 
            500                 505                 510         


His His His Gly Ser His His His His 
        515                 520     


<210>  22
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human matriptase-1 ECD protein his tag

<400>  22

Trp His Leu Gln Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly 
1               5                   10                  15      


Tyr Met Arg Ile Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser 
            20                  25                  30          


Asn Ser Thr Glu Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu 
        35                  40                  45              


Lys Leu Leu Tyr Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu 
    50                  55                  60                  


Ser Ala Val Thr Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp 
65                  70                  75                  80  


Ser Glu Phe Ser Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val 
                85                  90                  95      


Met Ala Glu Glu Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu 
            100                 105                 110         


Lys Ser Phe Val Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys 
        115                 120                 125             


Thr Val Gln Arg Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala 
    130                 135                 140                 


Arg Gly Val Glu Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala 
                165                 170                 175     


Asp Ser Val Leu Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys 
            180                 185                 190         


Asp Glu Arg Gly Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro 
        195                 200                 205             


Met Glu Pro His Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser 
    210                 215                 220                 


Tyr Asn Leu Thr Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu 
225                 230                 235                 240 


Ile Thr Asn Thr Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe 
                245                 250                 255     


Gln Leu Pro Arg Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln 
            260                 265                 270         


Gly Thr Phe Asn Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile 
        275                 280                 285             


Asp Cys Thr Trp Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val 
    290                 295                 300                 


Arg Phe Lys Phe Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr 
305                 310                 315                 320 


Cys Pro Lys Asp Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu 
                325                 330                 335     


Arg Ser Gln Phe Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg 
            340                 345                 350         


Phe His Ser Asp Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr 
        355                 360                 365             


Leu Ser Tyr Asp Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg 
    370                 375                 380                 


Thr Gly Arg Cys Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp 
385                 390                 395                 400 


Cys Thr Asp His Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His 
                405                 410                 415     


Gln Phe Thr Cys Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys 
            420                 425                 430         


Asp Ser Val Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser 
        435                 440                 445             


Cys Pro Ala Gln Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys 
    450                 455                 460                 


Ser Gln Gln Cys Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu 
465                 470                 475                 480 


Ala Ser Cys Pro Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr 
                485                 490                 495     


Arg Cys Leu Asn Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp 
            500                 505                 510         


Gly Lys Glu Asp Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys 
        515                 520                 525             


Gly Leu Arg Ser Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp 
    530                 535                 540                 


Ala Asp Glu Gly Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly 
545                 550                 555                 560 


Gln Gly His Ile Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val 
                565                 570                 575     


Ser Ala Ala His Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp 
            580                 585                 590         


Pro Thr Gln Trp Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg 
        595                 600                 605             


Ser Ala Pro Gly Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His 
    610                 615                 620                 


Pro Phe Phe Asn Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu 
625                 630                 635                 640 


Leu Glu Lys Pro Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu 
                645                 650                 655     


Pro Asp Ala Ser His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr 
            660                 665                 670         


Gly Trp Gly His Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln 
        675                 680                 685             


Lys Gly Glu Ile Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu 
    690                 695                 700                 


Pro Gln Gln Ile Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly 
705                 710                 715                 720 


Gly Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val 
                725                 730                 735     


Glu Ala Asp Gly Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp 
            740                 745                 750         


Gly Cys Ala Gln Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu 
        755                 760                 765             


Phe Arg Asp Trp Ile Lys Glu Asn Thr Gly Val Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Gly Ser His His His His His His 
785                 790                 795 


<210>  23
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse matriptase-2 ECD protein his tag

<400>  23

Tyr Lys Ala Glu Val Thr Val Ser Gln Val Tyr Ser Gly Ser Leu Arg 
1               5                   10                  15      


Val Leu Asn Arg His Phe Ser Gln Asp Leu Gly Arg Arg Glu Ser Ile 
            20                  25                  30          


Ala Phe Arg Ser Glu Ser Ala Lys Ala Gln Lys Met Leu Gln Glu Leu 
        35                  40                  45              


Val Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr 
    50                  55                  60                  


Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Asp 
65                  70                  75                  80  


Ile Pro Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val Val Arg Glu 
                85                  90                  95      


Leu Leu Val Asp Glu Leu Leu Ser Asn Ser Ser Thr Leu Ala Ser Tyr 
            100                 105                 110         


Lys Thr Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala 
        115                 120                 125             


Ser Val Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly Cys Tyr Arg 
    130                 135                 140                 


Tyr Ser Tyr Val Asn Pro Gly Gln Val Leu Pro Leu Lys Gly Pro Asp 
145                 150                 155                 160 


Gln Gln Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro Glu Asp Leu 
                165                 170                 175     


Met Ile Lys Val Arg Leu Glu Trp Thr Arg Val Asp Cys Arg Asp Arg 
            180                 185                 190         


Val Ala Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr 
        195                 200                 205             


Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu Val Leu Ala 
    210                 215                 220                 


Ser Gly Ser Val Met Ala Val Val Trp Lys Lys Gly Met His Ser Tyr 
225                 230                 235                 240 


Tyr Asp Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe Gln Asp Cys 
                245                 250                 255     


Gln Val Asn Leu Thr Leu Glu Gly Arg Leu Asp Thr Gln Gly Phe Leu 
            260                 265                 270         


Arg Thr Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr His Cys Ser 
        275                 280                 285             


Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe 
    290                 295                 300                 


Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Arg Leu Cys Thr Gln 
305                 310                 315                 320 


Gly Gln Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe Arg Thr Leu 
                325                 330                 335     


Gln Pro Tyr Ala Glu Arg Ile Pro Met Val Ala Ser Asp Gly Val Thr 
            340                 345                 350         


Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Gln Val 
        355                 360                 365             


Tyr Tyr Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu 
    370                 375                 380                 


Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Ile Lys Asp 
385                 390                 395                 400 


Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Met Phe 
                405                 410                 415     


Gln Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg Val Cys Asp 
            420                 425                 430         


Arg Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu 
        435                 440                 445             


Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys 
    450                 455                 460                 


Val Lys Lys Pro Asn Pro Glu Cys Asp Gly Gln Ser Asp Cys Arg Asp 
465                 470                 475                 480 


Gly Ser Asp Glu Gln His Cys Asp Cys Gly Leu Gln Gly Leu Ser Ser 
                485                 490                 495     


Arg Ile Val Gly Gly Thr Val Ser Ser Glu Gly Glu Trp Pro Trp Gln 
            500                 505                 510         


Ala Ser Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile 
        515                 520                 525             


Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser 
    530                 535                 540                 


Met Ala Ser Pro Lys Leu Trp Thr Val Phe Leu Gly Lys Met Arg Gln 
545                 550                 555                 560 


Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Phe 
                565                 570                 575     


Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu 
            580                 585                 590         


Leu Gln Leu Asp His Pro Val Val Tyr Ser Ala Thr Val Arg Pro Val 
        595                 600                 605             


Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln His Cys Trp 
    610                 615                 620                 


Ile Thr Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Val Ser Asn Thr 
625                 630                 635                 640 


Leu Gln Lys Val Asp Val Gln Leu Val Pro Gln Asp Leu Cys Ser Glu 
                645                 650                 655     


Ala Tyr Arg Tyr Gln Val Ser Pro Arg Met Leu Cys Ala Gly Tyr Arg 
            660                 665                 670         


Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        675                 680                 685             


Cys Arg Glu Pro Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp 
    690                 695                 700                 


Gly Leu Gly Cys Gly Arg Pro Asn Phe Phe Gly Val Tyr Thr Arg Val 
705                 710                 715                 720 


Thr Arg Val Ile Asn Trp Ile Gln Gln Val Leu Thr Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser His His His His His His Gly Ser His His 
            740                 745                 750         


His His 
        


<210>  24
<211>  170
<212>  PRT
<213>  Mus Musculus

<400>  24

Ala Ser Arg Glu Leu Asp Val His Glu Ser Cys Gly Val Ser Lys Val 
1               5                   10                  15      


Val Gly Lys Cys Arg Ala Ser Ile Pro Arg Trp Trp Tyr Asn Ile Thr 
            20                  25                  30          


Asp Gly Ser Cys Gln Pro Phe Val Tyr Gly Gly Cys Glu Gly Asn Gly 
        35                  40                  45              


Asn Asn Tyr Gln Ser Lys Glu Glu Cys Leu Asp Lys Cys Ala Gly Val 
    50                  55                  60                  


Thr Glu Asn Thr Thr Asp Asp Met Ala Arg Asn Arg Asn Gly Ala Asp 
65                  70                  75                  80  


Ser Ser Val Leu Ser Val Pro Arg Lys Gln Ser Ala Glu Asp Leu Ser 
                85                  90                  95      


Ala Glu Ile Phe Asn Tyr Glu Glu Tyr Cys Val Pro Lys Ala Val Thr 
            100                 105                 110         


Gly Pro Cys Arg Ala Ala Phe Pro Arg Trp Tyr Tyr Asp Thr Glu Lys 
        115                 120                 125             


Asn Ser Cys Ile Ser Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn 
    130                 135                 140                 


Ser Tyr Leu Ser Gln Glu Ala Cys Met Gln His Cys Ser Gly Lys Gln 
145                 150                 155                 160 


Met His Pro Phe Leu Thr Pro Gly Leu Lys 
                165                 170 


<210>  25
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno matriptase-2 ECD protein His tag

<400>  25

Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn Arg His Phe 
1               5                   10                  15      


Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr 
            20                  25                  30          


Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Ala Ser Thr Arg Leu 
        35                  40                  45              


Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro 
    50                  55                  60                  


Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu His Arg Arg 
65                  70                  75                  80  


Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val Glu Glu Leu 
                85                  90                  95      


Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr 
            100                 105                 110         


Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser Val Lys Asp 
        115                 120                 125             


Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val 
    130                 135                 140                 


Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His Leu Ala Ser 
145                 150                 155                 160 


Ser Cys Leu Trp His Leu Gln Gly Pro Glu Asp Leu Met Leu Lys Leu 
                165                 170                 175     


Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr 
            180                 185                 190         


Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly 
        195                 200                 205             


Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser Gly Ala Ile 
    210                 215                 220                 


Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe 
225                 230                 235                 240 


Met Leu Ser Val Gln Ser Val Val Phe Gln Ala Cys Glu Val Asn Leu 
                245                 250                 255     


Thr Leu Asp Asp Arg Leu Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr 
            260                 265                 270         


Phe Pro Ser Tyr Tyr Ser Pro Arg Thr His Cys Ser Trp His Leu Thr 
        275                 280                 285             


Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala 
    290                 295                 300                 


Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr 
305                 310                 315                 320 


Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala 
                325                 330                 335     


Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr 
            340                 345                 350         


Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His Tyr Gly Leu 
        355                 360                 365             


Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys Ser Val Asn 
    370                 375                 380                 


Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys Pro Asn Gly 
385                 390                 395                 400 


Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln Cys Gln Glu 
                405                 410                 415     


Asp Ser Thr Cys Ile Ser Leu Leu Lys Val Cys Asp Gly Gln Pro Asp 
            420                 425                 430         


Cys Leu Asn Gly Ser Asp Glu Glu Arg Cys Gln Glu Gly Val Pro Cys 
        435                 440                 445             


Gly Thr Phe Thr Phe Gln Cys Glu Asp Gln Ser Cys Val Lys Lys Pro 
    450                 455                 460                 


Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu 
465                 470                 475                 480 


Gln His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg Ile Val Gly 
                485                 490                 495     


Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln 
            500                 505                 510         


Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp 
        515                 520                 525             


Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met Ala Ser Pro 
    530                 535                 540                 


Ala Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn Ser Arg Trp 
545                 550                 555                 560 


Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu His Pro Tyr 
                565                 570                 575     


His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp 
            580                 585                 590         


His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys Leu Pro Ala 
        595                 600                 605             


Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile Thr Gly Trp 
    610                 615                 620                 


Gly Ala Leu Arg Glu Gly Gly Pro Thr Ser Asn Ala Leu Gln Lys Val 
625                 630                 635                 640 


Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Ala Tyr Arg Tyr 
                645                 650                 655     


Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys 
            660                 665                 670         


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Ala Leu 
        675                 680                 685             


Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly Leu Gly Cys 
    690                 695                 700                 


Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr Gly Val Ile 
705                 710                 715                 720 


Gly Trp Ile Gln Gln Val Val Thr Gly Gly Gly Gly Ser Gly Gly Gly 
                725                 730                 735     


Gly Ser His His His His His His Gly Ser His His His His 
            740                 745                 750 


<210>  26
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat matriptase-2 ECD protein his tag

<400>  26

Tyr Lys Ala Glu Val Thr Ile Ser Gln Val Tyr Ser Gly Ser Leu Arg 
1               5                   10                  15      


Val Leu Asn Arg His Phe Ser Gln Asp Leu Ala Arg Arg Glu Ser Ile 
            20                  25                  30          


Ala Phe Arg Thr Glu Thr Ala Lys Ala Gln Lys Met Phe Gln Glu Leu 
        35                  40                  45              


Val Ala Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Ile Tyr 
    50                  55                  60                  


Ala Phe Gly Glu Gly Pro Leu Ile Cys Phe Phe Trp Phe Ile Leu Asp 
65                  70                  75                  80  


Ile Pro Glu Tyr Gln Arg Leu Thr Leu Ser Pro Glu Val Val Arg Glu 
                85                  90                  95      


Leu Leu Val Gly Glu Leu Leu Ser Asn Ser Ser Ala Leu Ala Ser Tyr 
            100                 105                 110         


Arg Thr Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala 
        115                 120                 125             


Ser Val Asn Asp Ile Val Val Leu Asn Ser Thr Leu Gly Cys Tyr Arg 
    130                 135                 140                 


Tyr Ser Tyr Val Asn Pro Gly Gln Val Leu Arg Leu Arg Gly Pro Asp 
145                 150                 155                 160 


Gln Gln Thr Thr Ser Cys Leu Trp His Leu Gln Gly Pro Glu Asp Leu 
                165                 170                 175     


Met Leu Lys Val Gln Leu Glu Trp Thr Arg Val Asp Cys Arg Asp Arg 
            180                 185                 190         


Val Ala Met Tyr Asp Ala Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr 
        195                 200                 205             


Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Met Glu Val Leu Ala 
    210                 215                 220                 


Ser Gly Ser Val Met Ala Val Val Trp Lys Lys Gly Leu His Ser Phe 
225                 230                 235                 240 


Tyr Asp Pro Phe Leu Leu Ser Val Lys Ser Val Ala Phe Gln Asp Cys 
                245                 250                 255     


Gln Val Asn Leu Thr Leu Glu Gly Arg Leu Asp Pro Gln Gly Phe Leu 
            260                 265                 270         


Arg Thr Pro Tyr Tyr Pro Ser Tyr Tyr Ser Pro Ser Thr His Cys Ser 
        275                 280                 285             


Trp His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe 
    290                 295                 300                 


Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asn Leu Leu Cys Thr Gln 
305                 310                 315                 320 


Gly Gln Trp Met Ile Gln Asn Arg Arg Leu Cys Gly Phe Arg Thr Leu 
                325                 330                 335     


Gln Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Ser Asp Gly Ile Thr 
            340                 345                 350         


Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Gln Val 
        355                 360                 365             


Tyr Tyr Ser Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu 
    370                 375                 380                 


Cys Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Ile Lys Asp 
385                 390                 395                 400 


Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Met Phe 
                405                 410                 415     


Gln Cys Gln Glu Asp Ser Thr Cys Ile Ser Leu Pro Arg Val Cys Asp 
            420                 425                 430         


Arg Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu 
        435                 440                 445             


Gly Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys 
    450                 455                 460                 


Val Lys Lys Pro Asn Pro Glu Cys Asp Gly Gln Ala Asp Cys Arg Asp 
465                 470                 475                 480 


Gly Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser 
                485                 490                 495     


Arg Ile Val Gly Gly Ala Met Ser Ser Glu Gly Glu Trp Pro Trp Gln 
            500                 505                 510         


Ala Ser Leu Gln Ile Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile 
        515                 520                 525             


Ala Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser 
    530                 535                 540                 


Met Ala Ser Pro Arg Leu Trp Thr Val Phe Leu Gly Lys Met Arg Gln 
545                 550                 555                 560 


Asn Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Phe 
                565                 570                 575     


Leu His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu 
            580                 585                 590         


Leu Gln Leu Asp His Pro Val Val Tyr Ser Ala Thr Val Arg Pro Val 
        595                 600                 605             


Cys Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Gln His Cys Trp 
    610                 615                 620                 


Ile Thr Gly Trp Gly Ala Gln Arg Glu Gly Gly Pro Gly Ser Ser Thr 
625                 630                 635                 640 


Leu Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Asn Glu 
                645                 650                 655     


Ala Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg 
            660                 665                 670         


Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        675                 680                 685             


Cys Lys Glu Pro Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp 
    690                 695                 700                 


Gly Leu Gly Cys Gly Arg Pro Asn Phe Phe Gly Val Tyr Thr Arg Val 
705                 710                 715                 720 


Thr Arg Val Val Asn Trp Ile Gln Gln Val Leu Thr Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser His His His His His His Gly Ser His His 
            740                 745                 750         


His His 
        


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  27

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  28
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys Met Ser Arg Leu Cys Leu Ser Val Ala Leu Leu Val Leu Leu 
1               5                   10                  15      


Gly Thr Leu Ala Ala Ser Thr Pro Gly Cys Asp Thr Ser Asn Gln Ala 
            20                  25                  30          


Lys Ala Gln Arg Pro Asp Phe Cys Leu Glu Pro Pro Tyr Thr Gly Pro 
        35                  40                  45              


Cys Lys Ala Arg Ile Ile Arg Tyr Phe Tyr Asn Ala Lys Ala Gly Leu 
    50                  55                  60                  


Cys Gln Thr Phe Val Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe 
65                  70                  75                  80  


Lys Ser Ala Glu Asp Cys Met Arg Thr Cys Gly Gly Ala Ile Gly Pro 
                85                  90                  95      


Trp Glu Asn Leu 
            100 


<210>  29
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Tyr Thr Leu Ser Glu Phe Ser 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Asp Pro Glu Lys Gly Lys Thr 
1               5               


<210>  31
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Thr Glu Gly His Phe Tyr Gly Ser Gly Val Phe Asp Phe 
1               5                   10                  


<210>  32
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Phe Ser Ile His 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Phe Asp Pro Glu Lys Gly Lys Thr Ile Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Gly His Phe Tyr Gly Ser Gly Val Phe Asp Phe 
1               5                   10          


<210>  35
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Ser Glu Phe 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Lys Gly Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Glu Gly His Phe Tyr Gly Ser Gly Val Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  36
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  36
caggtccagc tggtacaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaaag tctccggata caccctcagt gaattctcca tacactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggc tttgatcctg aaaaaggtaa aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catcaacaga cacagcctac      240

atggacctga gcagcctgag atctgaggac acggccgtgt attactgtgt aacagaggga      300

catttctatg gttcgggggt ctttgacttc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  37
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Ser Glu Phe 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Lys Gly Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Glu Gly His Phe Tyr Gly Ser Gly Val Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  38
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  38
caggtccagc tggtacaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaaag tctccggata caccctcagt gaattctcca tacactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggc tttgatcctg aaaaaggtaa aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catcaacaga cacagcctac      240

atggacctga gcagcctgag atctgaggac acggccgtgt attactgtgt aacagaggga      300

catttctatg gttcgggggt ctttgacttc tggggccagg gaaccctggt caccgtctcc      360

tcagccagca ccaagggccc ttccgtgttc cccctggccc cttgcagcag gagcacctcc      420

gaatccacag ctgccctggg ctgtctggtg aaggactact ttcccgagcc cgtgaccgtg      480

agctggaaca gcggcgctct gacatccggc gtccacacct ttcctgccgt cctgcagtcc      540

tccggcctct actccctgtc ctccgtggtg accgtgccta gctcctccct cggcaccaag      600

acctacacct gtaacgtgga ccacaaaccc tccaacacca aggtggacaa acgggtcgag      660

agcaagtacg gccctccctg ccctccttgt cctgcccccg agttcgaagg cggacccagc      720

gtgttcctgt tccctcctaa gcccaaggac accctcatga tcagccggac acccgaggtg      780

acctgcgtgg tggtggatgt gagccaggag gaccctgagg tccagttcaa ctggtatgtg      840

gatggcgtgg aggtgcacaa cgccaagaca aagccccggg aagagcagtt caactccacc      900

tacagggtgg tcagcgtgct gaccgtgctg catcaggact ggctgaacgg caaggagtac      960

aagtgcaagg tcagcaataa gggactgccc agcagcatcg agaagaccat ctccaaggct     1020

aaaggccagc cccgggaacc tcaggtgtac accctgcctc ccagccagga ggagatgacc     1080

aagaaccagg tgagcctgac ctgcctggtg aagggattct acccttccga catcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aattataaga ccacccctcc cgtcctcgac     1200

agcgacggat ccttctttct gtactccagg ctgaccgtgg ataagtccag gtggcaggaa     1260

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1320

tccctgagcc tgtccctggg aaag                                            1344


<210>  39
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Gly Leu Arg Phe Asp 
1               5       


<210>  40
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Ala Ser 
1           


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Gln His Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Pro Ser Gln Gly Leu Arg Phe Asp Phe Gly 
1               5                   10      


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ala Ser Ile Leu Gln Ser 
1               5           


<210>  44
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Gly Leu Arg Phe Asp 
            20                  25                  30          


Phe Gly Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  45
gacatccaga tgacccagtc tccatcatcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc ggccaagtca gggccttaga tttgatttcg gctggtatca acagagacca      120

ggtaaagccc ctaggcgcct gatctatgcg gcatccattt tgcaaagtgg ggtcccatca      180

agattcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacaa cataacaatt atccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  46
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Gly Leu Arg Phe Asp 
            20                  25                  30          


Phe Gly Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  47
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  47
gacatccaga tgacccagtc tccatcatcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc ggccaagtca gggccttaga tttgatttcg gctggtatca acagagacca      120

ggtaaagccc ctaggcgcct gatctatgcg gcatccattt tgcaaagtgg ggtcccatca      180

agattcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacaa cataacaatt atccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Phe Thr Phe Gly Asp Phe Gly 
1               5               


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr 
1               5                   10  


<210>  50
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  50

Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
1               5                   10                  


<210>  51
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Phe Gly Met Ser 
1               5   


<210>  52
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  52

Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro Ser 
1               5                   10                  15      


Val Arg Gly 
            


<210>  53
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  53

Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
1               5                   10          


<210>  54
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Gly Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  55
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  55
gaggttcagt tggtggaatc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagctggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtatgtttc attagaagca aaccctatgg tggaacaaca      180

gattacgccc cgtctgtgag aggcagattc agcatctcaa gagatgattc caaaggcatc      240

gtctatctac agatgaacag cctgagaacc gaggacacag ccgtctatta ttgtagtaga      300

aacgaaattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  56
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Gly Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  57
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  57
gaggttcagt tggtggaatc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagctggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtatgtttc attagaagca aaccctatgg tggaacaaca      180

gattacgccc cgtctgtgag aggcagattc agcatctcaa gagatgattc caaaggcatc      240

gtctatctac agatgaacag cctgagaacc gaggacacag ccgtctatta ttgtagtaga      300

aacgaaattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  58
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  58

His Asp Ile Thr Asn Tyr 
1               5       


<210>  59
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  59

Asp Ala Ser 
1           


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Gln Tyr Tyr Asn Leu Pro Leu Thr 
1               5                   


<210>  61
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Ala Ser His Asp Ile Thr Asn Tyr Leu Ile 
1               5                   10      


<210>  62
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  62

Asp Ala Ser Ile Leu Glu Thr 
1               5           


<210>  63
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Ile Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  64
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  64
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca tgacattacc aactatttga tttggtatca gcagaaaccg      120

gggaaagccc ctagactcct tatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcaacaa tattataatc tcccgctcac tttcggcgga      300

ggaaccaagg tggacatcaa a                                                321


<210>  65
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Ile Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  66
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  66
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca tgacattacc aactatttga tttggtatca gcagaaaccg      120

gggaaagccc ctagactcct tatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcaacaa tattataatc tcccgctcac tttcggcgga      300

ggaaccaagg tggacatcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  67
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Gly Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  68
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  68
gaggttcagt tggtggaatc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagctggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aaccctatgg tggaacaaca      180

gattacgccc cgtctgtgag aggcagattc agcatctcaa gagatgattc caaaggcatc      240

gtctatctac agatgaacag cctgagaacc gaggacacag ccgtctatta ttgtagtaga      300

aacgaaattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  69
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Gly Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  70
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  70
gaggttcagt tggtggaatc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagctggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aaccctatgg tggaacaaca      180

gattacgccc cgtctgtgag aggcagattc agcatctcaa gagatgattc caaaggcatc      240

gtctatctac agatgaacag cctgagaacc gaggacacag ccgtctatta ttgtagtaga      300

aacgaaattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  71
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  71
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca tgacattacc aactatttga tttggtatca gcagaaaccg      120

gggaaagccc ctagactcct tatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcaacaa tattataatc tcccgctcac tttcggcgga      300

ggaaccaagg tggacatcaa a                                                321


<210>  72
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  72
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca tgacattacc aactatttga tttggtatca gcagaaaccg      120

gggaaagccc ctagactcct tatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcaacaa tattataatc tcccgctcac tttcggcgga      300

ggaaccaagg tggacatcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  73
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  73

Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  74
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asp Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  75
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  75
gaggtgcagt tggtggaatc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagctggtt ccgtcaggcg      120

ccagggaagg ggctggagtg ggtatgtttc attagaagca aaccctatgg tggaacaaca      180

gattacgccc cgtctgtgaa agacagattc accatctcaa gagatgattc caaagacatc      240

gtctatctgc aaatgaacag cctgagaacc gaggacacag ccgtctatta ttgtagtaga      300

aacgaaattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  76
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asp Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  77
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  77
gaggtgcagt tggtggaatc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagctggtt ccgtcaggcg      120

ccagggaagg ggctggagtg ggtatgtttc attagaagca aaccctatgg tggaacaaca      180

gattacgccc cgtctgtgaa agacagattc accatctcaa gagatgattc caaagacatc      240

gtctatctgc aaatgaacag cctgagaacc gaggacacag ccgtctatta ttgtagtaga      300

aacgaaattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  78
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  78
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca tgacattacc aactatttga tttggtatca gcagaaaccg      120

gggaaagccc ctagactcct tatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcaacaa tattataatt tgccgctcac tttcggcgga      300

gggaccaagg tggacatcaa a                                                321


<210>  79
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  79
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca tgacattacc aactatttga tttggtatca gcagaaaccg      120

gggaaagccc ctagactcct tatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcaacaa tattataatt tgccgctcac tttcggcgga      300

gggaccaagg tggacatcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  80
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
1               5                   10                  


<210>  81
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  81

Asp Phe Gly Leu Ser 
1               5   


<210>  82
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  82

Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  83
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Leu Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120             


<210>  84
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  84
gaggtacacc tggtggagtc tgggggaggc ttgataaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggtc tgagttggtt ccgccaggct      120

ccagggaagg ggctggaatg gatatctttc atcagaagca aaccttatgg tgggacaaca      180

gattacgccg cctctgtgaa aggcagattc accatttcaa gagatgattc caaaagcgtc      240

gcctatctgc aaatgaacag cctgaaaacc gaggactcag ccgtgtatta ctgtgccaga      300

aacgagattt tgactggtta ctatatcttt gactactggg gccagggaat cctggtcacc      360

gtctcctca                                                              369


<210>  85
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  85

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Leu Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  86
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  86
gaggtacacc tggtggagtc tgggggaggc ttgataaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggtc tgagttggtt ccgccaggct      120

ccagggaagg ggctggaatg gatatctttc atcagaagca aaccttatgg tgggacaaca      180

gattacgccg cctctgtgaa aggcagattc accatttcaa gagatgattc caaaagcgtc      240

gcctatctgc aaatgaacag cctgaaaacc gaggactcag ccgtgtatta ctgtgccaga      300

aacgagattt tgactggtta ctatatcttt gactactggg gccagggaat cctggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  87
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  88
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  89
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  89

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ser 
1               5                   10      


<210>  90
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Leu Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Leu Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Leu Lys 
            100                 105         


<210>  91
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  91
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagactcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa gttggtatca actgcaacca      120

gggaaagccc ctaagctcct gatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat ttttctttca ccgtcagtag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcggg      300

gggaccaagg tggatctcaa a                                                321


<210>  92
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Leu Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Leu Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  93
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  93
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagactcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa gttggtatca actgcaacca      120

gggaaagccc ctaagctcct gatcttcgat gcatccattt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat ttttctttca ccgtcagtag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcggg      300

gggaccaagg tggatctcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  94
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Leu Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  95
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  95
gaggtgcagc tggtggagtc tgggggagga ttgataaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggtc tgagctggtt ccgccaggct      120

ccagggaagg gactggaatg gatatctttc attagaagta aaccttatgg tgggacaaca      180

gattacgccg cctctgtgaa aggcagattc accatatcaa gagatgattc caaaaacgtc      240

gcctatctac aaatgaacag cctgaagacc gaggacacag ccgtgtatta ctgtgctaga      300

aacgagattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  96
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Leu Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asn Glu Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  97
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  97
gaggtgcagc tggtggagtc tgggggagga ttgataaagc cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggtc tgagctggtt ccgccaggct      120

ccagggaagg gactggaatg gatatctttc attagaagta aaccttatgg tgggacaaca      180

gattacgccg cctctgtgaa aggcagattc accatatcaa gagatgattc caaaaacgtc      240

gcctatctac aaatgaacag cctgaagacc gaggacacag ccgtgtatta ctgtgctaga      300

aacgagattt tgactggtta ttatatcttt gactactggg gccagggaac cctggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  98
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  98

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  99
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  99

Gln Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  100
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Val Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Phe Lys 
            100                 105         


<210>  101
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  101
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattaac aactatttaa attggtatca agtgcaacca      120

gggaaagccc ctaagctcct gatcttcgat gcatccattt tggaaacagg ggtcccatca      180

cggttcagtg gaagtggatc tgggacagat ttttctttca ccatcagtag cctgcagcct      240

gaagatattg caacatatta ctgtcaacaa tatgataatc tcccgctcac tttcggcgga      300

gggaccaagg tggatttcaa a                                                321


<210>  102
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Val Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Phe Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  103
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  103
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattaac aactatttaa attggtatca agtgcaacca      120

gggaaagccc ctaagctcct gatcttcgat gcatccattt tggaaacagg ggtcccatca      180

cggttcagtg gaagtggatc tgggacagat ttttctttca ccatcagtag cctgcagcct      240

gaagatattg caacatatta ctgtcaacaa tatgataatc tcccgctcac tttcggcgga      300

gggaccaagg tggatttcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  104
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  104

Ser Arg Asn Asp Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
1               5                   10                  


<210>  105
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  105

Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  106
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  106

Asn Asp Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
1               5                   10          


<210>  107
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Ile Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Thr Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Asp Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  108
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  108
gaggtgcagt tggtggaatc tgggggaggc ttggtaaaac cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagttggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtatgtttc attagaagca aaccttatgg tggaacaaca      180

gattatgccc cgtctgtgaa aggcagattc accatctcaa gagatgattc cataagcatc      240

gcctatctgc aaatgaatag cctgacaacc gaggacacag ccgtatatta ttgtagtcga      300

aacgatattt tgaccggtta ttatatcttt gactactggg gccagggaac ccaggtcacc      360

gtctcctca                                                              369


<210>  109
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Ile Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Thr Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Asp Ile Leu Thr Gly Tyr Tyr Ile Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  110
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  110
gaggtgcagt tggtggaatc tgggggaggc ttggtaaaac cagggcggtc cctgagactc       60

tcctgtacag gttctggatt cacctttggt gattttggta tgagttggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtatgtttc attagaagca aaccttatgg tggaacaaca      180

gattatgccc cgtctgtgaa aggcagattc accatctcaa gagatgattc cataagcatc      240

gcctatctgc aaatgaatag cctgacaacc gaggacacag ccgtatatta ttgtagtcga      300

aacgatattt tgaccggtta ttatatcttt gactactggg gccagggaac ccaggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  111
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  111

Gln Asp Ile Thr Asn Tyr 
1               5       


<210>  112
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Ile 
1               5                   10      


<210>  113
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  113

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  114
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Ser Ile Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Ile Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Tyr Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  115
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  115
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagcatcacc       60

atcacttgcc aggcgagtca ggacattacc aactatttaa tttggtatca gcataaaccg      120

gggaaagccc ctaaactcct tatcttcgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtgggtc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattatg caacgtatta ctgtcagcag tattataatc tcccgctcac tttcggcgga      300

gggaccaagg tggacatcaa a                                                321


<210>  116
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Ser Ile Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Ile Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Tyr Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  117
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  117
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctttaggaga cagcatcacc       60

atcacttgcc aggcgagtca ggacattacc aactatttaa tttggtatca gcataaaccg      120

gggaaagccc ctaaactcct tatcttcgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtgggtc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagattatg caacgtatta ctgtcagcag tattataatc tcccgctcac tttcggcgga      300

gggaccaagg tggacatcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  118
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  118

Gly Gly Ser Val Ser Ser Gly Arg Tyr Tyr 
1               5                   10  


<210>  119
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  119

Ile Ser Asn Ser Gly Asn Thr 
1               5           


<210>  120
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  120

Ala Arg Gly Phe Ile Tyr Asp Tyr Trp Phe Asp Pro 
1               5                   10          


<210>  121
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  121

Ser Gly Arg Tyr Tyr Trp Thr 
1               5           


<210>  122
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  122

Tyr Ile Ser Asn Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  123
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Phe Ile Tyr Asp Tyr Trp Phe Asp Pro 
1               5                   10  


<210>  124
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Arg Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Ser Asn Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  


Ser Leu Ser Leu Ser Ala Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Phe Ile Tyr Asp Tyr Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  125
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  125
caggtgcagc tgcaggagtc gggcccagga ctggtaaagc cttcggagac cctgtccctc       60

acatgtagtg tttctggtgg ctccgtcagc agtggtcgtt actattggac ctggatccgg      120

cagcccccag ggaagggact ggagtggatt ggatatatat ctaatagtgg gaacaccaac      180

tacaacccct ccctcaagag ccgagtcacc atatcccttg acacgtccaa gaaacagttc      240

tccctgagcc tgagtgctgt gaccgctgcg gacacggccg tatattactg tgcgcgagga      300

ttcatctatg attactggtt cgacccctgg ggccagggaa gcctggtcac cgtctcctca      360


<210>  126
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  126

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Arg Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Ser Asn Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  


Ser Leu Ser Leu Ser Ala Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Phe Ile Tyr Asp Tyr Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  127
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  127
caggtgcagc tgcaggagtc gggcccagga ctggtaaagc cttcggagac cctgtccctc       60

acatgtagtg tttctggtgg ctccgtcagc agtggtcgtt actattggac ctggatccgg      120

cagcccccag ggaagggact ggagtggatt ggatatatat ctaatagtgg gaacaccaac      180

tacaacccct ccctcaagag ccgagtcacc atatcccttg acacgtccaa gaaacagttc      240

tccctgagcc tgagtgctgt gaccgctgcg gacacggccg tatattactg tgcgcgagga      300

ttcatctatg attactggtt cgacccctgg ggccagggaa gcctggtcac cgtctcctca      360

gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa      420

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      540

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      600

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      660

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      720

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      780

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      840

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      900

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa     1020

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag     1140

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc     1200

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc     1260

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgagcctgt ccctgggaaa g                                               1341


<210>  128
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  128

Gln Asp Ile Asp Asn Tyr 
1               5       


<210>  129
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  129

Gln Gln Tyr Gly Asn Leu Pro Ile Thr 
1               5                   


<210>  130
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  130

Gln Ala Ser Gln Asp Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  131
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  131

Asp Ala Ser Lys Leu Glu Thr 
1               5           


<210>  132
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  132

Asp Ser Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys 
            100                 105         


<210>  133
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  133
gacagccaga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattgac aactatttaa attggtatca gcagagacca      120

gggaaagccc ctaaactcct gatctacgat gcatccaagt tggaaacggg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcaacct      240

gaagattttg caacatatta ctgtcaacaa tatggtaatc tcccgatcac cttcggccaa      300

gggacacgac tggacattaa a                                                321


<210>  134
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  134

Asp Ser Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  135
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  135
gacagccaga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattgac aactatttaa attggtatca gcagagacca      120

gggaaagccc ctaaactcct gatctacgat gcatccaagt tggaaacggg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcaacct      240

gaagattttg caacatatta ctgtcaacaa tatggtaatc tcccgatcac cttcggccaa      300

gggacacgac tggacattaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  136
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  136

Gly Phe Thr Phe Asn Asp His Val 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  137

Ile Ser Trp Asn Ser Asp Thr Ile 
1               5               


<210>  138
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  138

Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asp Tyr Phe Ala Met Asp 
1               5                   10                  15      


Val 
    


<210>  139
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  139

Asp His Val Ile Tyr 
1               5   


<210>  140
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  140

Thr Ile Ser Trp Asn Ser Asp Thr Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  141

Glu Lys Asp Gly Asp Phe Tyr Tyr Asp Tyr Phe Ala Met Asp Val 
1               5                   10                  15  


<210>  142
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp His 
            20                  25                  30          


Val Ile Tyr Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Ser Asp Thr Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asp Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  143
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  143
gaagtgcagt tggtggagtc tgggggaggc ttggttcagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaat gatcatgtca tatattgggt ccgacaagtt      120

ccaggaaagg gcctggagtg ggtctcaact attagttgga atagtgatac cattgcctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgccctatat      240

ctgcaaatga atagtctgag aactgaagac acggccttgt attactgtgc aagagaaaaa      300

gacggtgact tttactatga ctacttcgct atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  144
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp His 
            20                  25                  30          


Val Ile Tyr Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Ser Asp Thr Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asp Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  145
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  145
gaagtgcagt tggtggagtc tgggggaggc ttggttcagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaat gatcatgtca tatattgggt ccgacaagtt      120

ccaggaaagg gcctggagtg ggtctcaact attagttgga atagtgatac cattgcctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgccctatat      240

ctgcaaatga atagtctgag aactgaagac acggccttgt attactgtgc aagagaaaaa      300

gacggtgact tttactatga ctacttcgct atggacgtct ggggccaagg gaccacggtc      360

accgtctcct cagccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  146
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  146

Ser Ser Asp Val Gly Tyr Tyr Asn Tyr 
1               5                   


<210>  147
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  147

Glu Val Ser 
1           


<210>  148
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  148

Ser Ser Tyr Ala Gly Ser Asn Lys Val Val 
1               5                   10  


<210>  149
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  149

Thr Gly Thr Ser Ser Asp Val Gly Tyr Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  150
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  150

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  151
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  151

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Tyr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Leu Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Lys Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  152
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  152
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccctc       60

tcctgcactg gaaccagtag tgacgttggt tattataact atgtctcctg gtacctacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tttctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattattgc agctcatatg caggcagcaa caaagtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  153
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  153

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Tyr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Leu Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Lys Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  154
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  154
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccctc       60

tcctgcactg gaaccagtag tgacgttggt tattataact atgtctcctg gtacctacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tttctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattattgc agctcatatg caggcagcaa caaagtggta      300

ttcggcggag ggaccaaggt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  155
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  155

Gly Phe Thr Phe Asp Asp His Val 
1               5               


<210>  156
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  156

Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
1               5                   10                  15      


Val 
    


<210>  157
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  157

Asp His Val Met Tyr 
1               5   


<210>  158
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  158

Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  159

Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp Val 
1               5                   10                  15  


<210>  160
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Pro 
        115                 120                 


<210>  161
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  161
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaaggt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gaccacggtc      360

accgtctccc ca                                                          372


<210>  162
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Pro Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  163
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  163
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaaggt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gaccacggtc      360

accgtctccc cagccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Ser Ser Asp Val Gly Phe Tyr Asn Phe 
1               5                   


<210>  165
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  165

Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr Asn Phe Val Ser 
1               5                   10                  


<210>  166
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  166

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Lys Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  167
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  167
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ctattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta                                       330


<210>  168
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  168

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Lys Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  169
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  169
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ctattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  170
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  171
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  171
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaaggt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  172
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  173
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  173
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaaggt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct cagccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  174
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  174
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ctattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta                                       330


<210>  175
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  175
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ctattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  176
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  177
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  177
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaaggt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gacaatggtc      360

accgtctctt ca                                                          372


<210>  178
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  179
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  179
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaaggt      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gacaatggtc      360

accgtctctt cagccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  180
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  180
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ctattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta                                       330


<210>  181
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  181
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ctattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  182
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Pro 
        115                 120                 


<210>  183
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  183
gaagtgcagt tagtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcacatga acagtctgag acctgaggac acggccttat attactgtgc gagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gaccacggtc      360

accgtctccc ca                                                          372


<210>  184
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Gly Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Asn Tyr Phe Val Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Pro Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  185
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  185
gaagtgcagt tagtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gatcatgtca tgtattgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cattggctat      180

gcggacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cgtcctatat      240

ctgcacatga acagtctgag acctgaggac acggccttat attactgtgc gagagagaaa      300

gacggtgact tttactataa ctacttcgtt atggacgtct ggggccaagg gaccacggtc      360

accgtctccc cagccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  186
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  186
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta                                       330


<210>  187
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  187
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacag      120

cacccagaca aagcccccaa agtcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa caaagtggtt      300

ttcggcggag ggaccaagtt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  188
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  188

Gly Phe Thr Phe Asp Glu His Val 
1               5               


<210>  189
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  189

Ile Ser Trp Lys Ser Asp Ile Ile 
1               5               


<210>  190
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  190

Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
1               5                   10                  15      


Val 
    


<210>  191
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  191

Glu His Val Ile Tyr 
1               5   


<210>  192
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  192

Ser Ile Ser Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  193
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  193

Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp Val 
1               5                   10                  15  


<210>  194
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His 
            20                  25                  30          


Val Ile Tyr Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  195
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  195
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tctactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atctcctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ct                                                          372


<210>  196
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His 
            20                  25                  30          


Val Ile Tyr Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  197
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  197
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tctactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atctcctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ctgccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  198
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  198
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccctc       60

tcctgcactg gaaccagtag tgacgttggt tattataact atgtctcctg gtacctacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tttctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattattgc agctcatatg caggcagcaa caaagtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  199
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  199
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccctc       60

tcctgcactg gaaccagtag tgacgttggt tattataact atgtctcctg gtacctacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tttctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattattgc agctcatatg caggcagcaa caaagtggta      300

ttcggcggag ggaccaaggt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  200
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  200

Ile Thr Trp Lys Ser Asp Ile Ile 
1               5               


<210>  201
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  201

Glu His Val Met Tyr 
1               5   


<210>  202
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  202

Ser Ile Thr Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  203
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Thr Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  204
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  204
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tgtactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atcacctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ct                                                          372


<210>  205
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  205

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Thr Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  206
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  206
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tgtactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atcacctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ctgccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  207
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  207
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccctc       60

tcctgcactg gaaccagtag tgacgttggt tattataact atgtctcctg gtacctacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tttctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattattgc agctcatatg caggcagcaa caaagtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  208
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  208
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccctc       60

tcctgcactg gaaccagtag tgacgttggt tattataact atgtctcctg gtacctacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tttctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattattgc agctcatatg caggcagcaa caaagtggta      300

ttcggcggag ggaccaaggt gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  209
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  209
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tctactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atctcctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ct                                                          372


<210>  210
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His 
            20                  25                  30          


Val Ile Tyr Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  211
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  211
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tctactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atctcctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ctgccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  212
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  212

Ser Ser Asn Val Gly Tyr Tyr Asn Tyr 
1               5                   


<210>  213
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  213

Glu Val Asn 
1           


<210>  214
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  214

Thr Gly Thr Ser Ser Asn Val Gly Tyr Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  215
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  215

Glu Val Asn Lys Arg Pro Ser 
1               5           


<210>  216
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  216

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Val Gly Tyr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Lys Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  217
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  217
cagtctgctc tgacccagcc tccttctgct tctggctctc ctggccagtc cgtgaccatc       60

tcttgtaccg gcacctcctc caacgtgggc tactacaact acgtgtcctg gtatcagcag      120

caccccggca aggctcccaa gctgatgatc tacgaagtga acaagcggcc ctctggcgtg      180

cccgatagat tctccggatc caagtccgcc aataccgcct ctctgaccgt gtctggactg      240

caggctgatg acgaggccga ctactactgc tcctcttacg ccggctccaa caaggtggtg      300

tttggcggcg gaacaaagct gacagtgctg                                       330


<210>  218
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  218

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Val Gly Tyr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Lys Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  219
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  219
cagtctgctc tgacccagcc tccttctgct tctggctctc ctggccagtc cgtgaccatc       60

tcttgtaccg gcacctcctc caacgtgggc tactacaact acgtgtcctg gtatcagcag      120

caccccggca aggctcccaa gctgatgatc tacgaagtga acaagcggcc ctctggcgtg      180

cccgatagat tctccggatc caagtccgcc aataccgcct ctctgaccgt gtctggactg      240

caggctgatg acgaggccga ctactactgc tcctcttacg ccggctccaa caaggtggtg      300

tttggcggcg gaacaaagct gacagtgctg ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  220
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  220
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tgtactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atcacctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ct                                                          372


<210>  221
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  221

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Thr Trp Lys Ser Asp Ile Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Gly Asp Phe Tyr Tyr Tyr Tyr Phe Ala Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  222
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  222
gaggtgcagc tggttgaatc tggcggagga ctgatccagg ccggcagatc tctgagactg       60

tcttgtgccg cctccggctt caccttcgat gagcacgtga tgtactgggt ccgacagatc      120

cctggcaaag gcctggaatg gatctcctcc atcacctgga agtccgacat cattgcctac      180

gccgactccg tgaagggcag attcaccatc tccagagaca acgccaagaa cgccctgtac      240

ctgcagatga actccctgag agccgaggac accgctctgt actactgcgc cagagagaag      300

gacggcgact tttactacta ctatttcgcc atggacgtgt ggggccaggg caccacagtg      360

acagtttctt ctgccagcac caagggccct tccgtgttcc ccctggcccc ttgcagcagg      420

agcacctccg aatccacagc tgccctgggc tgtctggtga aggactactt tcccgagccc      480

gtgaccgtga gctggaacag cggcgctctg acatccggcg tccacacctt tcctgccgtc      540

ctgcagtcct ccggcctcta ctccctgtcc tccgtggtga ccgtgcctag ctcctccctc      600

ggcaccaaga cctacacctg taacgtggac cacaaaccct ccaacaccaa ggtggacaaa      660

cgggtcgaga gcaagtacgg ccctccctgc cctccttgtc ctgcccccga gttcgaaggc      720

ggacccagcg tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagccggaca      780

cccgaggtga cctgcgtggt ggtggatgtg agccaggagg accctgaggt ccagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaac gccaagacaa agccccggga agagcagttc      900

aactccacct acagggtggt cagcgtgctg accgtgctgc atcaggactg gctgaacggc      960

aaggagtaca agtgcaaggt cagcaataag ggactgccca gcagcatcga gaagaccatc     1020

tccaaggcta aaggccagcc ccgggaacct caggtgtaca ccctgcctcc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggattcta cccttccgac     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca attataagac cacccctccc     1200

gtcctcgaca gcgacggatc cttctttctg tactccaggc tgaccgtgga taagtccagg     1260

tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtccctggga aag                                  1353


<210>  223
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  223
cagtctgctc tgacccagcc tccttctgct tctggctctc ctggccagtc cgtgaccatc       60

tcttgtaccg gcacctcctc caacgtgggc tactacaact acgtgtcctg gtatcagcag      120

caccccggca aggctcccaa gctgatgatc tacgaagtga acaagcggcc ctctggcgtg      180

cccgatagat tctccggatc caagtccgcc aataccgcct ctctgaccgt gtctggactg      240

caggctgatg acgaggccga ctactactgc tcctcttacg ccggctccaa caaggtggtg      300

tttggcggcg gaacaaagct gacagtgctg                                       330


<210>  224
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  224
cagtctgctc tgacccagcc tccttctgct tctggctctc ctggccagtc cgtgaccatc       60

tcttgtaccg gcacctcctc caacgtgggc tactacaact acgtgtcctg gtatcagcag      120

caccccggca aggctcccaa gctgatgatc tacgaagtga acaagcggcc ctctggcgtg      180

cccgatagat tctccggatc caagtccgcc aataccgcct ctctgaccgt gtctggactg      240

caggctgatg acgaggccga ctactactgc tcctcttacg ccggctccaa caaggtggtg      300

tttggcggcg gaacaaagct gacagtgctg ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  225
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  225

Gly Phe Thr Phe Ser Asn Phe Asp 
1               5               


<210>  226
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  226

Ile Arg Tyr Asp Glu Thr Asn Ile 
1               5               


<210>  227
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  227

Ala Arg Gly Trp Thr Gly Ser Tyr Val Phe Asp Tyr 
1               5                   10          


<210>  228
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  228

Asn Phe Asp Met His 
1               5   


<210>  229
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  229

Ile Ile Arg Tyr Asp Glu Thr Asn Ile Tyr Tyr Thr Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  230
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  230

Gly Trp Thr Gly Ser Tyr Val Phe Asp Tyr 
1               5                   10  


<210>  231
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  231

Gln Val His Leu Val Glu Ser Gly Gly Ala Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Ile Ile Arg Tyr Asp Glu Thr Asn Ile Tyr Tyr Thr Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Thr Gly Ser Tyr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Leu Val Thr Val Ser Ser 
        115                 


<210>  232
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  232
caggtgcacc tggtggagtc tgggggagcc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactttgaca tgcactgggt ccgccagact      120

ccaggcaagg ggctggagtg ggtgacaatt attcggtatg atgaaactaa tatatactat      180

acagagtccg tgaagggccg tttcaccacc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agtcgaggac acggctgtgt attactgtgc gagagggtgg      300

actgggagtt atgtctttga ctactggggc cagggagccc tggtcaccgt ctcctca         357


<210>  233
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  233

Gln Val His Leu Val Glu Ser Gly Gly Ala Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Ile Ile Arg Tyr Asp Glu Thr Asn Ile Tyr Tyr Thr Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Thr Gly Ser Tyr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  234
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  234
caggtgcacc tggtggagtc tgggggagcc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactttgaca tgcactgggt ccgccagact      120

ccaggcaagg ggctggagtg ggtgacaatt attcggtatg atgaaactaa tatatactat      180

acagagtccg tgaagggccg tttcaccacc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agtcgaggac acggctgtgt attactgtgc gagagggtgg      300

actgggagtt atgtctttga ctactggggc cagggagccc tggtcaccgt ctcctcagcc      360

agcaccaagg gcccttccgt gttccccctg gccccttgca gcaggagcac ctccgaatcc      420

acagctgccc tgggctgtct ggtgaaggac tactttcccg agcccgtgac cgtgagctgg      480

aacagcggcg ctctgacatc cggcgtccac acctttcctg ccgtcctgca gtcctccggc      540

ctctactccc tgtcctccgt ggtgaccgtg cctagctcct ccctcggcac caagacctac      600

acctgtaacg tggaccacaa accctccaac accaaggtgg acaaacgggt cgagagcaag      660

tacggccctc cctgccctcc ttgtcctgcc cccgagttcg aaggcggacc cagcgtgttc      720

ctgttccctc ctaagcccaa ggacaccctc atgatcagcc ggacacccga ggtgacctgc      780

gtggtggtgg atgtgagcca ggaggaccct gaggtccagt tcaactggta tgtggatggc      840

gtggaggtgc acaacgccaa gacaaagccc cgggaagagc agttcaactc cacctacagg      900

gtggtcagcg tgctgaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc      960

aaggtcagca ataagggact gcccagcagc atcgagaaga ccatctccaa ggctaaaggc     1020

cagccccggg aacctcaggt gtacaccctg cctcccagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaaggga ttctaccctt ccgacatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaattat aagaccaccc ctcccgtcct cgacagcgac     1200

ggatccttct ttctgtactc caggctgacc gtggataagt ccaggtggca ggaaggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc tgggaaag                                                   1338


<210>  235
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  235

Ser Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210>  236
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  236

Tyr Asp Asp 
1           


<210>  237
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  237

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  238
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  238

Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  239
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  239

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  240
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  240

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Val Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile His Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  241
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  241
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaggcagttc caacatcgga aataatgctg taaactggta ccagcaggtc      120

ccaggaaagg ctcccaaact cctcatccat tatgatgatc tactgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tggactccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag gtaccaagct gaccgtccta                                       330


<210>  242
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  242

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Val Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile His Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  243
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  243
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaggcagttc caacatcgga aataatgctg taaactggta ccagcaggtc      120

ccaggaaagg ctcccaaact cctcatccat tatgatgatc tactgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tggactccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag gtaccaagct gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  244
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  244

Gly Tyr Thr Phe Thr Thr Phe Gly 
1               5               


<210>  245
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  245

Ile Ser Gly Tyr Asn Gly Asn Thr 
1               5               


<210>  246
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  246

Ala Arg Asp Arg Ala Ile Ala Pro Arg Phe Asp Pro 
1               5                   10          


<210>  247
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  247

Thr Phe Gly Ile Val 
1               5   


<210>  248
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  248

Trp Ile Ser Gly Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Asn Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  249
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  249

Asp Arg Ala Ile Ala Pro Arg Phe Asp Pro 
1               5                   10  


<210>  250
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  250

Gln Leu Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Gly Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Asn Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Ile Ala Pro Arg Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  251
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  251
cagcttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc acctttggta tcgtctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa cacaaagtat      180

gcacagaatc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggaactga ggagcctgag atctgacgac acggccatat attactgtgc gagagatagg      300

gctatagcac ctcgcttcga cccctggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  252
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  252

Gln Leu Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Gly Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Asn Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Ile Ala Pro Arg Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  253
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  253
cagcttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc acctttggta tcgtctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa cacaaagtat      180

gcacagaatc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggaactga ggagcctgag atctgacgac acggccatat attactgtgc gagagatagg      300

gctatagcac ctcgcttcga cccctggggc cagggaaccc tggtcaccgt ctcctcagcc      360

agcaccaagg gcccttccgt gttccccctg gccccttgca gcaggagcac ctccgaatcc      420

acagctgccc tgggctgtct ggtgaaggac tactttcccg agcccgtgac cgtgagctgg      480

aacagcggcg ctctgacatc cggcgtccac acctttcctg ccgtcctgca gtcctccggc      540

ctctactccc tgtcctccgt ggtgaccgtg cctagctcct ccctcggcac caagacctac      600

acctgtaacg tggaccacaa accctccaac accaaggtgg acaaacgggt cgagagcaag      660

tacggccctc cctgccctcc ttgtcctgcc cccgagttcg aaggcggacc cagcgtgttc      720

ctgttccctc ctaagcccaa ggacaccctc atgatcagcc ggacacccga ggtgacctgc      780

gtggtggtgg atgtgagcca ggaggaccct gaggtccagt tcaactggta tgtggatggc      840

gtggaggtgc acaacgccaa gacaaagccc cgggaagagc agttcaactc cacctacagg      900

gtggtcagcg tgctgaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc      960

aaggtcagca ataagggact gcccagcagc atcgagaaga ccatctccaa ggctaaaggc     1020

cagccccggg aacctcaggt gtacaccctg cctcccagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaaggga ttctaccctt ccgacatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaattat aagaccaccc ctcccgtcct cgacagcgac     1200

ggatccttct ttctgtactc caggctgacc gtggataagt ccaggtggca ggaaggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc tgggaaag                                                   1338


<210>  254
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  254

Asn Leu Gly Asp Asn Phe 
1               5       


<210>  255
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  255

Gln Asp Ser 
1           


<210>  256
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  256

Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   


<210>  257
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  257

Ser Gly Asp Asn Leu Gly Asp Asn Phe Ala Cys 
1               5                   10      


<210>  258
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  258

Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210>  259
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  259

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Ala Ala Ser Ile Pro Cys Ser Gly Asp Asn Leu Gly Asp Asn Phe Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  260
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  260
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacaggc agccagcatc       60

ccctgctctg gagataattt gggggataac tttgcttgct ggtatcagca gaagccaggc      120

cagtctcctg tgttggtcat ctatcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcaacgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  261
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  261

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Ala Ala Ser Ile Pro Cys Ser Gly Asp Asn Leu Gly Asp Asn Phe Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  262
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  262
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacaggc agccagcatc       60

ccctgctctg gagataattt gggggataac tttgcttgct ggtatcagca gaagccaggc      120

cagtctcctg tgttggtcat ctatcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcaacgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg      300

accaagctga ccgtcctagg acagccaaaa gcagccccat ccgtaactct gttcccacct      360

agttcagagg agcttcaagc aaacaaagcc acacttgttt gccttattag tgatttttat      420

cccggtgccg tgacagttgc ctggaaagct gatagctcac cagtgaaagc tggcgtggag      480

acaaccacac catctaaaca aagcaataac aagtatgctg ccagctcata tctgagtctc      540

actccagaac aatggaagtc tcatcggtcc tatagctgtc aagtgaccca cgaaggcagt      600

accgtcgaga agaccgtggc accaacagag tgtagc                                636


<210>  263
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  263

Ile Ser Tyr Asp Gly Ser Asp Lys 
1               5               


<210>  264
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  264

Ala Lys Asp Gly Tyr Gly Ser Ser Leu Phe Asp His 
1               5                   10          


<210>  265
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  265

Ile Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Glu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  266
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  266

Asp Gly Tyr Gly Ser Ser Leu Phe Asp His 
1               5                   10  


<210>  267
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  267

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Tyr Gly Ser Ser Leu Phe Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  268
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  268
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctcgggatt caccttcagt aactttgaca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt atatcatatg atggaagtga taaatattat      180

gaagactccg tgaagggccg attcaccatc tccagagaca attccaaaaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctattt attattgtgc gaaagatggg      300

tatggcagtt ccctctttga ccactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  269
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  269

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Tyr Gly Ser Ser Leu Phe Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  270
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  270
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctcgggatt caccttcagt aactttgaca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt atatcatatg atggaagtga taaatattat      180

gaagactccg tgaagggccg attcaccatc tccagagaca attccaaaaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctattt attattgtgc gaaagatggg      300

tatggcagtt ccctctttga ccactggggc cagggaaccc tggtcaccgt ctcctcagcc      360

agcaccaagg gcccttccgt gttccccctg gccccttgca gcaggagcac ctccgaatcc      420

acagctgccc tgggctgtct ggtgaaggac tactttcccg agcccgtgac cgtgagctgg      480

aacagcggcg ctctgacatc cggcgtccac acctttcctg ccgtcctgca gtcctccggc      540

ctctactccc tgtcctccgt ggtgaccgtg cctagctcct ccctcggcac caagacctac      600

acctgtaacg tggaccacaa accctccaac accaaggtgg acaaacgggt cgagagcaag      660

tacggccctc cctgccctcc ttgtcctgcc cccgagttcg aaggcggacc cagcgtgttc      720

ctgttccctc ctaagcccaa ggacaccctc atgatcagcc ggacacccga ggtgacctgc      780

gtggtggtgg atgtgagcca ggaggaccct gaggtccagt tcaactggta tgtggatggc      840

gtggaggtgc acaacgccaa gacaaagccc cgggaagagc agttcaactc cacctacagg      900

gtggtcagcg tgctgaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc      960

aaggtcagca ataagggact gcccagcagc atcgagaaga ccatctccaa ggctaaaggc     1020

cagccccggg aacctcaggt gtacaccctg cctcccagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaaggga ttctaccctt ccgacatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaattat aagaccaccc ctcccgtcct cgacagcgac     1200

ggatccttct ttctgtactc caggctgacc gtggataagt ccaggtggca ggaaggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc tgggaaag                                                   1338


<210>  271
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  271

Ala Val Trp Asp Asp Ser Leu Asn Gly Val Leu 
1               5                   10      


<210>  272
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  272

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  273
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  273

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Phe Gln Gln Leu Pro Gly Glu Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  274
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  274
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggtt ccagcagctc      120

ccaggagagg ttcccaaact cctcatctat tatgatgatc tgctgccctc aggagtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gtttgggatg acagcctgaa tggtgtccta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  275
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  275

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Phe Gln Gln Leu Pro Gly Glu Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  276
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  276
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggtt ccagcagctc      120

ccaggagagg ttcccaaact cctcatctat tatgatgatc tgctgccctc aggagtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gtttgggatg acagcctgaa tggtgtccta      300

ttcggcggag ggaccaagct gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  277
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  277

Gly Asp Ser Ile Ser Ser Ser His Tyr Phe 
1               5                   10  


<210>  278
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  279
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  279

Val Arg His Asn Asn Trp Gly Leu Asp Asn Tyr Phe Asp Tyr 
1               5                   10                  


<210>  280
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  280

Ser Ser His Tyr Phe Trp Gly 
1               5           


<210>  281
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  281

Ser Met Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  282
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  282

His Asn Asn Trp Gly Leu Asp Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  283
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  283

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ala Glu 
1               5                   10                  15      


Thr Leu Ser Leu Met Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 
            20                  25                  30          


His Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Asn Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg His Asn Asn Trp Gly Leu Asp Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  284
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  284
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc ctgcggagac cctgtccctc       60

atgtgcactg tctctggtga ctccatcagt agtagtcatt acttctgggg ctggatccgc      120

cagcccccag ggaagggcct ggagtggatt gggagtatgt attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa caaccagttt      240

tccctgaagc tgaggtctgt gaccgccgca gacacggctg tgtattattg tgtgagacat      300

aataattggg gattggacaa ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  285
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  285

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ala Glu 
1               5                   10                  15      


Thr Leu Ser Leu Met Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 
            20                  25                  30          


His Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Asn Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg His Asn Asn Trp Gly Leu Asp Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  286
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  286
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc ctgcggagac cctgtccctc       60

atgtgcactg tctctggtga ctccatcagt agtagtcatt acttctgggg ctggatccgc      120

cagcccccag ggaagggcct ggagtggatt gggagtatgt attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa caaccagttt      240

tccctgaagc tgaggtctgt gaccgccgca gacacggctg tgtattattg tgtgagacat      300

aataattggg gattggacaa ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcagcca gcaccaaggg cccttccgtg ttccccctgg ccccttgcag caggagcacc      420

tccgaatcca cagctgccct gggctgtctg gtgaaggact actttcccga gcccgtgacc      480

gtgagctgga acagcggcgc tctgacatcc ggcgtccaca cctttcctgc cgtcctgcag      540

tcctccggcc tctactccct gtcctccgtg gtgaccgtgc ctagctcctc cctcggcacc      600

aagacctaca cctgtaacgt ggaccacaaa ccctccaaca ccaaggtgga caaacgggtc      660

gagagcaagt acggccctcc ctgccctcct tgtcctgccc ccgagttcga aggcggaccc      720

agcgtgttcc tgttccctcc taagcccaag gacaccctca tgatcagccg gacacccgag      780

gtgacctgcg tggtggtgga tgtgagccag gaggaccctg aggtccagtt caactggtat      840

gtggatggcg tggaggtgca caacgccaag acaaagcccc gggaagagca gttcaactcc      900

acctacaggg tggtcagcgt gctgaccgtg ctgcatcagg actggctgaa cggcaaggag      960

tacaagtgca aggtcagcaa taagggactg cccagcagca tcgagaagac catctccaag     1020

gctaaaggcc agccccggga acctcaggtg tacaccctgc ctcccagcca ggaggagatg     1080

accaagaacc aggtgagcct gacctgcctg gtgaagggat tctacccttc cgacatcgcc     1140

gtggagtggg agtccaacgg ccagcccgag aacaattata agaccacccc tcccgtcctc     1200

gacagcgacg gatccttctt tctgtactcc aggctgaccg tggataagtc caggtggcag     1260

gaaggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag     1320

aagtccctga gcctgtccct gggaaag                                         1347


<210>  287
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  287

Ala Leu Pro Asp Gln Tyr 
1               5       


<210>  288
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  288

Lys Asp Ser 
1           


<210>  289
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  289

Gln Ser Ala Asp Ser Ser Gly Ser Tyr Ala Val 
1               5                   10      


<210>  290
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  290

Ser Ala Asp Ala Leu Pro Asp Gln Tyr Ala Tyr 
1               5                   10      


<210>  291
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  291

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  292
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  292

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Pro Asp Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Ile Val Thr Leu Thr Ile Arg Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Ser Tyr 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  293
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  293
tcctatgagc tgacgcagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg cagatgcatt gccagaccaa tatgcttatt ggtaccagca gaagccaggc      120

caggcccctc tgttggtcat atataaagac agtgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaatagtc acgttgacca tccgtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcagtg gttcttatgc ggtattcggc      300

ggagggacca agttgaccgt ccta                                             324


<210>  294
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  294

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Pro Asp Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Ile Val Thr Leu Thr Ile Arg Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Ser Tyr 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  295
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  295
tcctatgagc tgacgcagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg cagatgcatt gccagaccaa tatgcttatt ggtaccagca gaagccaggc      120

caggcccctc tgttggtcat atataaagac agtgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaatagtc acgttgacca tccgtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcagtg gttcttatgc ggtattcggc      300

ggagggacca agttgaccgt cctaggacag ccaaaagcag ccccatccgt aactctgttc      360

ccacctagtt cagaggagct tcaagcaaac aaagccacac ttgtttgcct tattagtgat      420

ttttatcccg gtgccgtgac agttgcctgg aaagctgata gctcaccagt gaaagctggc      480

gtggagacaa ccacaccatc taaacaaagc aataacaagt atgctgccag ctcatatctg      540

agtctcactc cagaacaatg gaagtctcat cggtcctata gctgtcaagt gacccacgaa      600

ggcagtaccg tcgagaagac cgtggcacca acagagtgta gc                         642


<210>  296
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  296

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  297
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  297

Ile Ser Ser Ser Gly Arg Thr Arg 
1               5               


<210>  298
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  298

Ala Arg Ala Gln Leu Arg Tyr Phe Asp Trp Leu Asp Tyr 
1               5                   10              


<210>  299
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  299

Asp Tyr Tyr Met Gly 
1               5   


<210>  300
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  300

His Ile Ser Ser Ser Gly Arg Thr Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  301
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  301

Ala Gln Leu Arg Tyr Phe Asp Trp Leu Asp Tyr 
1               5                   10      


<210>  302
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  302

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Arg Thr Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Tyr Phe Asp Trp Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  303
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  303
caggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctttggatt caccttcagt gactactaca tgggctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtaggac caggtactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa tgcactgtat      240

ctgcaaatgg acagcctgag agccgaagac acggccgtat tttactgtgc gagagcccaa      300

ttacgatatt ttgactggct tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  304
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  304

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Arg Thr Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Tyr Phe Asp Trp Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  305
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  305
caggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctttggatt caccttcagt gactactaca tgggctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtaggac caggtactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa tgcactgtat      240

ctgcaaatgg acagcctgag agccgaagac acggccgtat tttactgtgc gagagcccaa      300

ttacgatatt ttgactggct tgactactgg ggccagggaa ccctggtcac cgtctcctca      360

gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa      420

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      540

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      600

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      660

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      720

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      780

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      840

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      900

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa     1020

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag     1140

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc     1200

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc     1260

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgagcctgt ccctgggaaa g                                               1341


<210>  306
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  306

Gly Ser Asn Ile Gly Asn Asn Tyr 
1               5               


<210>  307
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  307

Asp Asn Asn 
1           


<210>  308
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  308

Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  309
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  309

Ser Gly Ser Gly Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  310
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  310

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  311
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  311

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  312
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  312
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcggctc caacattggg aataattatg tatcctggta ccagcaggtc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctggggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  313
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  313

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  314
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  314
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcggctc caacattggg aataattatg tatcctggta ccagcaggtc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctggggtg      300

ttcggcggag ggaccaagct gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  315
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  315

Gly Phe Thr Phe Ser Thr Tyr Thr 
1               5               


<210>  316
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  316

Ile Ser Ile Arg Asn Ser Ile Ile 
1               5               


<210>  317
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  317

Ala Arg Glu Glu Phe Cys Gly Thr Thr Ser Cys Tyr Phe Leu Asp Tyr 
1               5                   10                  15      


<210>  318
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  318

Thr Tyr Thr Met Asn 
1               5   


<210>  319
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  319

Tyr Ile Ser Ile Arg Asn Ser Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  320
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  320

Glu Glu Phe Cys Gly Thr Thr Ser Cys Tyr Phe Leu Asp Tyr 
1               5                   10                  


<210>  321
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  321

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Arg Asn Ser Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Phe Cys Gly Thr Thr Ser Cys Tyr Phe Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120             


<210>  322
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  322
gaggtgcggc tggtggagtc tgggggaggc ttggttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtatta ggaatagtat catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggctgttt attattgtgc gagagaggag      300

ttttgtggta ctaccagctg ctatttcctt gactactggg gccagggaat cctggtcacc      360

gtctcctca                                                              369


<210>  323
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  323

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Arg Asn Ser Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Phe Cys Gly Thr Thr Ser Cys Tyr Phe Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  324
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  324
gaggtgcggc tggtggagtc tgggggaggc ttggttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtatta ggaatagtat catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggctgttt attattgtgc gagagaggag      300

ttttgtggta ctaccagctg ctatttcctt gactactggg gccagggaat cctggtcacc      360

gtctcctcag ccagcaccaa gggcccttcc gtgttccccc tggccccttg cagcaggagc      420

acctccgaat ccacagctgc cctgggctgt ctggtgaagg actactttcc cgagcccgtg      480

accgtgagct ggaacagcgg cgctctgaca tccggcgtcc acacctttcc tgccgtcctg      540

cagtcctccg gcctctactc cctgtcctcc gtggtgaccg tgcctagctc ctccctcggc      600

accaagacct acacctgtaa cgtggaccac aaaccctcca acaccaaggt ggacaaacgg      660

gtcgagagca agtacggccc tccctgccct ccttgtcctg cccccgagtt cgaaggcgga      720

cccagcgtgt tcctgttccc tcctaagccc aaggacaccc tcatgatcag ccggacaccc      780

gaggtgacct gcgtggtggt ggatgtgagc caggaggacc ctgaggtcca gttcaactgg      840

tatgtggatg gcgtggaggt gcacaacgcc aagacaaagc cccgggaaga gcagttcaac      900

tccacctaca gggtggtcag cgtgctgacc gtgctgcatc aggactggct gaacggcaag      960

gagtacaagt gcaaggtcag caataaggga ctgcccagca gcatcgagaa gaccatctcc     1020

aaggctaaag gccagccccg ggaacctcag gtgtacaccc tgcctcccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gattctaccc ttccgacatc     1140

gccgtggagt gggagtccaa cggccagccc gagaacaatt ataagaccac ccctcccgtc     1200

ctcgacagcg acggatcctt ctttctgtac tccaggctga ccgtggataa gtccaggtgg     1260

caggaaggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc cctgggaaag                                      1350


<210>  325
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  325

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  326
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  326

Gly Asn Ser 
1           


<210>  327
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  327

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  328
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  328

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  329
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  329

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  330
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  330

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  331
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  331
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc caggtcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210>  332
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  332

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  333
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  333
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc caggtcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctaggacagc caaaagcagc cccatccgta      360

actctgttcc cacctagttc agaggagctt caagcaaaca aagccacact tgtttgcctt      420

attagtgatt tttatcccgg tgccgtgaca gttgcctgga aagctgatag ctcaccagtg      480

aaagctggcg tggagacaac cacaccatct aaacaaagca ataacaagta tgctgccagc      540

tcatatctga gtctcactcc agaacaatgg aagtctcatc ggtcctatag ctgtcaagtg      600

acccacgaag gcagtaccgt cgagaagacc gtggcaccaa cagagtgtag c               651


<210>  334
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  334

Ile Ser Ser Ser Gly Gly Asn Arg 
1               5               


<210>  335
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  335

Ala Arg Gly Gly Leu Arg Tyr Phe Asp Trp Ala Asp Phe 
1               5                   10              


<210>  336
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  336

Asp Tyr Tyr Met Ser 
1               5   


<210>  337
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  337

Tyr Ile Ser Ser Ser Gly Gly Asn Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  338
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  338

Gly Gly Leu Arg Tyr Phe Asp Trp Ala Asp Phe 
1               5                   10      


<210>  339
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  339

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Gly Asn Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Arg Tyr Phe Asp Trp Ala Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  340
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  340
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtggtaa cagatactat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaggggga      300

ttacgatatt ttgactgggc tgacttctgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  341
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  341

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Gly Asn Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Arg Tyr Phe Asp Trp Ala Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  342
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  342
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtggtaa cagatactat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaggggga      300

ttacgatatt ttgactgggc tgacttctgg ggccagggaa ccctggtcac cgtctcctca      360

gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa      420

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      540

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      600

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      660

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      720

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      780

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      840

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      900

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa     1020

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag     1140

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc     1200

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc     1260

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgagcctgt ccctgggaaa g                                               1341


<210>  343
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  343

Ser Ser Asn Ile Gly Asn Asn Tyr 
1               5               


<210>  344
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  344

Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  345
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  345

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  346
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  346

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Pro Glu Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  347
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  347
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta tcagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc ggggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatccc cgaactccag      240

actggggacg aggccgatta ttactgcgga acatgggata acagcctgag tgctggggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  348
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  348

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Pro Glu Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  349
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  349
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta tcagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc ggggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatccc cgaactccag      240

actggggacg aggccgatta ttactgcgga acatgggata acagcctgag tgctggggtg      300

ttcggcggag ggaccaagct gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  350
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  350

Gly Tyr Thr Phe Thr Asn Phe Gly 
1               5               


<210>  351
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  351

Ile Ser Ala Tyr Ser Gly Phe Thr 
1               5               


<210>  352
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  352

Ala Arg Glu Gly Tyr Ser Asn Tyr Glu Asp Trp Phe Asp Pro 
1               5                   10                  


<210>  353
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  353

Asn Phe Gly Ile Ser 
1               5   


<210>  354
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  354

Trp Ile Ser Ala Tyr Ser Gly Phe Thr Asn Phe Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  355
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  355

Glu Gly Tyr Ser Asn Tyr Glu Asp Trp Phe Asp Pro 
1               5                   10          


<210>  356
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  356

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Phe Thr Asn Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Asn Tyr Glu Asp Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  357
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  357
caggttcagc tggtgcagtc tggacctgag ttgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc aactttggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggctgg atcagcgctt acagtggttt cacaaacttt      180

gcacagaagt tccagggcag agtcagcatg accacagaca catccacgag cacagtctac      240

atggagctga agagcctgag atctgacgac acggccgtat attactgtgc gagagagggt      300

tacagtaact acgaggactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  358
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  358

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Phe Thr Asn Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Asn Tyr Glu Asp Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  359
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  359
caggttcagc tggtgcagtc tggacctgag ttgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc aactttggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggctgg atcagcgctt acagtggttt cacaaacttt      180

gcacagaagt tccagggcag agtcagcatg accacagaca catccacgag cacagtctac      240

atggagctga agagcctgag atctgacgac acggccgtat attactgtgc gagagagggt      300

tacagtaact acgaggactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tcagccagca ccaagggccc ttccgtgttc cccctggccc cttgcagcag gagcacctcc      420

gaatccacag ctgccctggg ctgtctggtg aaggactact ttcccgagcc cgtgaccgtg      480

agctggaaca gcggcgctct gacatccggc gtccacacct ttcctgccgt cctgcagtcc      540

tccggcctct actccctgtc ctccgtggtg accgtgccta gctcctccct cggcaccaag      600

acctacacct gtaacgtgga ccacaaaccc tccaacacca aggtggacaa acgggtcgag      660

agcaagtacg gccctccctg ccctccttgt cctgcccccg agttcgaagg cggacccagc      720

gtgttcctgt tccctcctaa gcccaaggac accctcatga tcagccggac acccgaggtg      780

acctgcgtgg tggtggatgt gagccaggag gaccctgagg tccagttcaa ctggtatgtg      840

gatggcgtgg aggtgcacaa cgccaagaca aagccccggg aagagcagtt caactccacc      900

tacagggtgg tcagcgtgct gaccgtgctg catcaggact ggctgaacgg caaggagtac      960

aagtgcaagg tcagcaataa gggactgccc agcagcatcg agaagaccat ctccaaggct     1020

aaaggccagc cccgggaacc tcaggtgtac accctgcctc ccagccagga ggagatgacc     1080

aagaaccagg tgagcctgac ctgcctggtg aagggattct acccttccga catcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aattataaga ccacccctcc cgtcctcgac     1200

agcgacggat ccttctttct gtactccagg ctgaccgtgg ataagtccag gtggcaggaa     1260

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1320

tccctgagcc tgtccctggg aaag                                            1344


<210>  360
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  360

Ala Leu Pro Lys Lys Tyr 
1               5       


<210>  361
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  361

Glu Asp Ser 
1           


<210>  362
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  362

Tyr Ser Thr Asp Ser Ser Gly Asn His Arg Val 
1               5                   10      


<210>  363
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  363

Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala Tyr 
1               5                   10      


<210>  364
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  364

Glu Asp Ser Lys Arg Pro Ser 
1               5           


<210>  365
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  365

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  366
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  366
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaaa tatgcttact ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctatgaggac agcaaacgac cctccgggat ccctgagaga      180

atctctggct ccaactcagg gacaatggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttactcaaca gacagcagtg gtaatcatag ggtattcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  367
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  367

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  368
<211>  972
<212>  DNA
<213>  Homo sapiens

<400>  368
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaaa tatgcttact ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctatgaggac agcaaacgac cctccgggat ccctgagaga      180

atctctggct ccaactcagg gacaatggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttactcaaca gacagcagtg gtaatcatag ggtattcggc      300

ggagggacca agctgaccgt cctacagtct gtgttgacgc agccgccctc agtgtctgcg      360

gccccaggac agaaggtcac catctcctgc tctggaagca gctccaacat tgggaataat      420

tatgtatcct ggtatcagca gctcccagga acagccccca aactcctcat ttatgacaat      480

aataagcgac cctcggggat tcctgaccga ttctctggct ccaagtctgg cacgtcagcc      540

accctgggca tccccgaact ccagactggg gacgaggccg attattactg cggaacatgg      600

gataacagcc tgagtgctgg ggtgttcggc ggagggacca agctgaccgt cctaggacag      660

ccaaaagcag ccccatccgt aactctgttc ccacctagtt cagaggagct tcaagcaaac      720

aaagccacac ttgtttgcct tattagtgat ttttatcccg gtgccgtgac agttgcctgg      780

aaagctgata gctcaccagt gaaagctggc gtggagacaa ccacaccatc taaacaaagc      840

aataacaagt atgctgccag ctcatatctg agtctcactc cagaacaatg gaagtctcat      900

cggtcctata gctgtcaagt gacccacgaa ggcagtaccg tcgagaagac cgtggcacca      960

acagagtgta gc                                                          972


<210>  369
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  369

Gly Val Thr Phe Thr Asn Phe Asp 
1               5               


<210>  370
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  370

Ile Trp Tyr Asp Glu Ser Tyr Ser 
1               5               


<210>  371
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  371

Val Ile Trp Tyr Asp Glu Ser Tyr Ser Tyr Tyr Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  372
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  372

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Phe Thr Asn Phe 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Glu Ser Tyr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Thr Gly Ser Tyr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  373
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  373
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cgtctggagt caccttcact aactttgaca tgcactgggt ccgccagact      120

ccaggcaagg ggctggagtg ggtggcggtt atttggtatg atgaaagtta ttcatattat      180

gcagactccg tgcagggccg attcaccatc tccagagaca attccaagaa ctccctgtat      240

ctgcaaatga acagcctgag agccgatgac acggctgtgt attactgtgc gagagggtgg      300

actgggagct acgtctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  374
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  374

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Phe Thr Asn Phe 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Glu Ser Tyr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Thr Gly Ser Tyr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  375
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  375
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cgtctggagt caccttcact aactttgaca tgcactgggt ccgccagact      120

ccaggcaagg ggctggagtg ggtggcggtt atttggtatg atgaaagtta ttcatattat      180

gcagactccg tgcagggccg attcaccatc tccagagaca attccaagaa ctccctgtat      240

ctgcaaatga acagcctgag agccgatgac acggctgtgt attactgtgc gagagggtgg      300

actgggagct acgtctttga ctactggggc cagggaaccc tggtcaccgt ctcctcagcc      360

agcaccaagg gcccttccgt gttccccctg gccccttgca gcaggagcac ctccgaatcc      420

acagctgccc tgggctgtct ggtgaaggac tactttcccg agcccgtgac cgtgagctgg      480

aacagcggcg ctctgacatc cggcgtccac acctttcctg ccgtcctgca gtcctccggc      540

ctctactccc tgtcctccgt ggtgaccgtg cctagctcct ccctcggcac caagacctac      600

acctgtaacg tggaccacaa accctccaac accaaggtgg acaaacgggt cgagagcaag      660

tacggccctc cctgccctcc ttgtcctgcc cccgagttcg aaggcggacc cagcgtgttc      720

ctgttccctc ctaagcccaa ggacaccctc atgatcagcc ggacacccga ggtgacctgc      780

gtggtggtgg atgtgagcca ggaggaccct gaggtccagt tcaactggta tgtggatggc      840

gtggaggtgc acaacgccaa gacaaagccc cgggaagagc agttcaactc cacctacagg      900

gtggtcagcg tgctgaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc      960

aaggtcagca ataagggact gcccagcagc atcgagaaga ccatctccaa ggctaaaggc     1020

cagccccggg aacctcaggt gtacaccctg cctcccagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaaggga ttctaccctt ccgacatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaattat aagaccaccc ctcccgtcct cgacagcgac     1200

ggatccttct ttctgtactc caggctgacc gtggataagt ccaggtggca ggaaggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc tgggaaag                                                   1338


<210>  376
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  376

Ala Ala Trp Asp Asp Ser Leu Asn Ala Val Val 
1               5                   10      


<210>  377
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  377

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  378
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  378
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg ggagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctct tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgcggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tgctgtggta      300

tttggcggag ggaccaagct gaccgtccta                                       330


<210>  379
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  379

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  380
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  380
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg ggagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctct tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgcggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tgctgtggta      300

tttggcggag ggaccaagct gaccgtccta cagtctgtgt tgacgcagcc gccctcagtg      360

tctgcggccc caggacagaa ggtcaccatc tcctgctctg gaagcagctc caacattggg      420

aataattatg tatcctggta tcagcagctc ccaggaacag cccccaaact cctcatttat      480

gacaataata agcgaccctc ggggattcct gaccgattct ctggctccaa gtctggcacg      540

tcagccaccc tgggcatccc cgaactccag actggggacg aggccgatta ttactgcgga      600

acatgggata acagcctgag tgctggggtg ttcggcggag ggaccaagct gaccgtccta      660

ggacagccaa aagcagcccc atccgtaact ctgttcccac ctagttcaga ggagcttcaa      720

gcaaacaaag ccacacttgt ttgccttatt agtgattttt atcccggtgc cgtgacagtt      780

gcctggaaag ctgatagctc accagtgaaa gctggcgtgg agacaaccac accatctaaa      840

caaagcaata acaagtatgc tgccagctca tatctgagtc tcactccaga acaatggaag      900

tctcatcggt cctatagctg tcaagtgacc cacgaaggca gtaccgtcga gaagaccgtg      960

gcaccaacag agtgtagc                                                    978


<210>  381
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  381

Gly Phe Thr Phe Ser Tyr Phe Gly 
1               5               


<210>  382
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  382

Ile Ser Tyr Asp Gly Ser Asp Glu 
1               5               


<210>  383
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  383

Ala Lys Glu Thr Tyr Gln Ser Leu Met Tyr Leu Glu Tyr 
1               5                   10              


<210>  384
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  384

Tyr Phe Gly Met His 
1               5   


<210>  385
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  385

Asp Ile Ser Tyr Asp Gly Ser Asp Glu Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  386
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  386

Glu Thr Tyr Gln Ser Leu Met Tyr Leu Glu Tyr 
1               5                   10      


<210>  387
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  387

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Ser Tyr Asp Gly Ser Asp Glu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Thr Tyr Gln Ser Leu Met Tyr Leu Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Thr Val Ser Ser 
        115                 120 


<210>  388
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  388
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt tattttggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagat atatcatatg atggaagtga tgaaaactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtct      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagagacg      300

tatcagtcac tgatgtatct tgagtactgg ggccagggaa tcctggtcac cgtctcctca      360


<210>  389
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  389

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Ser Tyr Asp Gly Ser Asp Glu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Thr Tyr Gln Ser Leu Met Tyr Leu Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  390
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  390
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt tattttggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagat atatcatatg atggaagtga tgaaaactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtct      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagagacg      300

tatcagtcac tgatgtatct tgagtactgg ggccagggaa tcctggtcac cgtctcctca      360

gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa      420

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      540

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      600

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      660

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      720

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      780

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      840

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      900

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa     1020

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag     1140

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc     1200

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc     1260

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgagcctgt ccctgggaaa g                                               1341


<210>  391
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  391

Gln Asp Ile Arg Asn Asp 
1               5       


<210>  392
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  392

Thr Ala Pro 
1           


<210>  393
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  393

Leu Gln Asp Tyr Asn Tyr Pro Trp Thr 
1               5                   


<210>  394
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  394

Arg Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  395
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  395

Thr Ala Pro Ser Leu Gln Ser 
1               5           


<210>  396
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  396

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Pro Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  397
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  397
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatact gcacccagtt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcaccgat ttcactctca ccatcggcag cctgcagcct      240

gaagattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  398
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  398

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Pro Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  399
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  399
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatact gcacccagtt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcaccgat ttcactctca ccatcggcag cctgcagcct      240

gaagattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  400
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  400

Gly Tyr Thr Phe Asn Asn Tyr Gly 
1               5               


<210>  401
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  401

Ile Ser Ala Tyr Ser Gly Tyr Thr 
1               5               


<210>  402
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  402

Ala Arg Glu Gly Tyr Ser Asn Phe Glu Asp Trp Phe Asp Pro 
1               5                   10                  


<210>  403
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  403

Asn Tyr Gly Ile Ser 
1               5   


<210>  404
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  404

Trp Ile Ser Ala Tyr Ser Gly Tyr Thr Asn Ile Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  405
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  405

Glu Gly Tyr Ser Asn Phe Glu Asp Trp Phe Asp Pro 
1               5                   10          


<210>  406
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  406

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Tyr Thr Asn Ile Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Asn Phe Glu Asp Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  407
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  407
caggttcagt tggtgcagtc tggagctgag ttgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttaac aactatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acagtggtta cacaaacatt      180

gcacagaagt tccagggtag agtcaccatg accacagaca catccacgaa cacagtctac      240

atggaactgg ggagcctgag atctgacgac acggccgtgt attactgtgc gagagagggc      300

tacagtaact tcgaagactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  408
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  408

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Tyr Thr Asn Ile Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Asn Phe Glu Asp Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  409
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  409
caggttcagt tggtgcagtc tggagctgag ttgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttaac aactatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acagtggtta cacaaacatt      180

gcacagaagt tccagggtag agtcaccatg accacagaca catccacgaa cacagtctac      240

atggaactgg ggagcctgag atctgacgac acggccgtgt attactgtgc gagagagggc      300

tacagtaact tcgaagactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tcagccagca ccaagggccc ttccgtgttc cccctggccc cttgcagcag gagcacctcc      420

gaatccacag ctgccctggg ctgtctggtg aaggactact ttcccgagcc cgtgaccgtg      480

agctggaaca gcggcgctct gacatccggc gtccacacct ttcctgccgt cctgcagtcc      540

tccggcctct actccctgtc ctccgtggtg accgtgccta gctcctccct cggcaccaag      600

acctacacct gtaacgtgga ccacaaaccc tccaacacca aggtggacaa acgggtcgag      660

agcaagtacg gccctccctg ccctccttgt cctgcccccg agttcgaagg cggacccagc      720

gtgttcctgt tccctcctaa gcccaaggac accctcatga tcagccggac acccgaggtg      780

acctgcgtgg tggtggatgt gagccaggag gaccctgagg tccagttcaa ctggtatgtg      840

gatggcgtgg aggtgcacaa cgccaagaca aagccccggg aagagcagtt caactccacc      900

tacagggtgg tcagcgtgct gaccgtgctg catcaggact ggctgaacgg caaggagtac      960

aagtgcaagg tcagcaataa gggactgccc agcagcatcg agaagaccat ctccaaggct     1020

aaaggccagc cccgggaacc tcaggtgtac accctgcctc ccagccagga ggagatgacc     1080

aagaaccagg tgagcctgac ctgcctggtg aagggattct acccttccga catcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aattataaga ccacccctcc cgtcctcgac     1200

agcgacggat ccttctttct gtactccagg ctgaccgtgg ataagtccag gtggcaggaa     1260

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1320

tccctgagcc tgtccctggg aaag                                            1344


<210>  410
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  410

Glu Leu Pro Lys Lys Tyr 
1               5       


<210>  411
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  411

Ser Gly Asp Glu Leu Pro Lys Lys Tyr Ala Tyr 
1               5                   10      


<210>  412
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  412

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Glu Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  413
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  413
tcctatgagc tgacacagcc tccctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgaatt gccaaaaaaa tatgcttatt ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctatgaggac agcaaacgac cctccgggat ccctgagaga      180

atctctggct ccaactcagg gacaatggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttactcaaca gacagcagtg gtaatcatag ggtattcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  414
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  414

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Glu Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  415
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  415
tcctatgagc tgacacagcc tccctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgaatt gccaaaaaaa tatgcttatt ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctatgaggac agcaaacgac cctccgggat ccctgagaga      180

atctctggct ccaactcagg gacaatggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttactcaaca gacagcagtg gtaatcatag ggtattcggc      300

ggagggacca agctgaccgt cctaggacag ccaaaagcag ccccatccgt aactctgttc      360

ccacctagtt cagaggagct tcaagcaaac aaagccacac ttgtttgcct tattagtgat      420

ttttatcccg gtgccgtgac agttgcctgg aaagctgata gctcaccagt gaaagctggc      480

gtggagacaa ccacaccatc taaacaaagc aataacaagt atgctgccag ctcatatctg      540

agtctcactc cagaacaatg gaagtctcat cggtcctata gctgtcaagt gacccacgaa      600

ggcagtaccg tcgagaagac cgtggcacca acagagtgta gc                         642


<210>  416
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  416

Gly Phe Ile Leu Asp Asp Tyr Gly 
1               5               


<210>  417
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  417

Ile Ser Trp Asn Gly Asp Ser Thr 
1               5               


<210>  418
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  418

Ala Arg Glu Tyr Ser Gly Asp Phe Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  419
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  419

Asp Tyr Gly Met Asn 
1               5   


<210>  420
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  420

Gly Ile Ser Trp Asn Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  421
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  421

Glu Tyr Ser Gly Asp Phe Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  422
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  422

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Phe Ile Leu Asp Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Asn Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Gly Asp Phe Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  423
<211>  371
<212>  DNA
<213>  Homo sapiens

<400>  423
gaggtgcagc tggtggagtc tgggggagct gtggtacggc ctggggggtc cctgaggctc       60

tcctgtgcaa tttctggatt catcttggat gactatggca tgaactgggt ccgccaaggt      120

ccagggaagg ggctggagtg ggtcgctggt attagttgga atggtgatag cacacgttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgcccagaa ctccctgtat      240

ctgcaaatga aagtctgaga gccgaggaca cggccttgta tttctgtgcg agagaatata      300

gtggagactt ctactattac tactacggta tggacgtctg gggccaaggg accacggtca      360

ccgtctcctc a                                                           371


<210>  424
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  424

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Phe Ile Leu Asp Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Asn Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Gly Asp Phe Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  425
<211>  1352
<212>  DNA
<213>  Homo sapiens

<400>  425
gaggtgcagc tggtggagtc tgggggagct gtggtacggc ctggggggtc cctgaggctc       60

tcctgtgcaa tttctggatt catcttggat gactatggca tgaactgggt ccgccaaggt      120

ccagggaagg ggctggagtg ggtcgctggt attagttgga atggtgatag cacacgttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgcccagaa ctccctgtat      240

ctgcaaatga aagtctgaga gccgaggaca cggccttgta tttctgtgcg agagaatata      300

gtggagactt ctactattac tactacggta tggacgtctg gggccaaggg accacggtca      360

ccgtctcctc agccagcacc aagggccctt ccgtgttccc cctggcccct tgcagcagga      420

gcacctccga atccacagct gccctgggct gtctggtgaa ggactacttt cccgagcccg      480

tgaccgtgag ctggaacagc ggcgctctga catccggcgt ccacaccttt cctgccgtcc      540

tgcagtcctc cggcctctac tccctgtcct ccgtggtgac cgtgcctagc tcctccctcg      600

gcaccaagac ctacacctgt aacgtggacc acaaaccctc caacaccaag gtggacaaac      660

gggtcgagag caagtacggc cctccctgcc ctccttgtcc tgcccccgag ttcgaaggcg      720

gacccagcgt gttcctgttc cctcctaagc ccaaggacac cctcatgatc agccggacac      780

ccgaggtgac ctgcgtggtg gtggatgtga gccaggagga ccctgaggtc cagttcaact      840

ggtatgtgga tggcgtggag gtgcacaacg ccaagacaaa gccccgggaa gagcagttca      900

actccaccta cagggtggtc agcgtgctga ccgtgctgca tcaggactgg ctgaacggca      960

aggagtacaa gtgcaaggtc agcaataagg gactgcccag cagcatcgag aagaccatct     1020

ccaaggctaa aggccagccc cgggaacctc aggtgtacac cctgcctccc agccaggagg     1080

agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggattctac ccttccgaca     1140

tcgccgtgga gtgggagtcc aacggccagc ccgagaacaa ttataagacc acccctcccg     1200

tcctcgacag cgacggatcc ttctttctgt actccaggct gaccgtggat aagtccaggt     1260

ggcaggaagg caacgtgttc agctgctccg tgatgcacga ggccctgcac aatcactaca     1320

cccagaagtc cctgagcctg tccctgggaa ag                                   1352


<210>  426
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  426

Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 
1               5                   10  


<210>  427
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  427

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  428
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  428
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacat      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agttcatatg caggcagcaa caatttggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  429
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  429

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  430
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  430
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ttttataact ttgtctcctg gtaccaacat      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctgcc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agttcatatg caggcagcaa caatttggtg      300

ttcggcggag ggaccaagct gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  431
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  431

Gly Phe Thr Phe Gly Asp Tyr Val 
1               5               


<210>  432
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  432

Ile Arg Ser Lys Pro Tyr Ser Glu Thr Thr 
1               5                   10  


<210>  433
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  433

Thr Arg Ala Leu Tyr Asp Leu Leu Thr Gly Pro Trp Met Gly Gly Asp 
1               5                   10                  15      


Tyr Phe Tyr Ala Leu Asp Val 
            20              


<210>  434
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  434

Asp Tyr Val Met Ser 
1               5   


<210>  435
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  435

Phe Ile Arg Ser Lys Pro Tyr Ser Glu Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Arg Gly 
            


<210>  436
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  436

Ala Leu Tyr Asp Leu Leu Thr Gly Pro Trp Met Gly Gly Asp Tyr Phe 
1               5                   10                  15      


Tyr Ala Leu Asp Val 
            20      


<210>  437
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  437

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Val Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Pro Tyr Ser Glu Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Ala Leu Tyr Asp Leu Leu Thr Gly Pro Trp Met Gly 
            100                 105                 110         


Gly Asp Tyr Phe Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  438
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  438
gaggttcaac tggtggagtc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgtta tgagctggtt ccgccaggct      120

ccagggaagg gactggagtg ggtaggtttc attagaagca aaccttatag tgagacaaca      180

gaatacgccg cgtctgtgag aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtactaga      300

gccctttacg atcttttgac tggtccatgg atgggagggg actacttcta cgctttggac      360

gtctggggcc aagggaccac ggtcaccgtc tcctca                                396


<210>  439
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  439

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Val Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Pro Tyr Ser Glu Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Ala Leu Tyr Asp Leu Leu Thr Gly Pro Trp Met Gly 
            100                 105                 110         


Gly Asp Tyr Phe Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 


<210>  440
<211>  1377
<212>  DNA
<213>  Homo sapiens

<400>  440
gaggttcaac tggtggagtc tgggggaggc ttggtaaagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgtta tgagctggtt ccgccaggct      120

ccagggaagg gactggagtg ggtaggtttc attagaagca aaccttatag tgagacaaca      180

gaatacgccg cgtctgtgag aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtactaga      300

gccctttacg atcttttgac tggtccatgg atgggagggg actacttcta cgctttggac      360

gtctggggcc aagggaccac ggtcaccgtc tcctcagcca gcaccaaggg cccttccgtg      420

ttccccctgg ccccttgcag caggagcacc tccgaatcca cagctgccct gggctgtctg      480

gtgaaggact actttcccga gcccgtgacc gtgagctgga acagcggcgc tctgacatcc      540

ggcgtccaca cctttcctgc cgtcctgcag tcctccggcc tctactccct gtcctccgtg      600

gtgaccgtgc ctagctcctc cctcggcacc aagacctaca cctgtaacgt ggaccacaaa      660

ccctccaaca ccaaggtgga caaacgggtc gagagcaagt acggccctcc ctgccctcct      720

tgtcctgccc ccgagttcga aggcggaccc agcgtgttcc tgttccctcc taagcccaag      780

gacaccctca tgatcagccg gacacccgag gtgacctgcg tggtggtgga tgtgagccag      840

gaggaccctg aggtccagtt caactggtat gtggatggcg tggaggtgca caacgccaag      900

acaaagcccc gggaagagca gttcaactcc acctacaggg tggtcagcgt gctgaccgtg      960

ctgcatcagg actggctgaa cggcaaggag tacaagtgca aggtcagcaa taagggactg     1020

cccagcagca tcgagaagac catctccaag gctaaaggcc agccccggga acctcaggtg     1080

tacaccctgc ctcccagcca ggaggagatg accaagaacc aggtgagcct gacctgcctg     1140

gtgaagggat tctacccttc cgacatcgcc gtggagtggg agtccaacgg ccagcccgag     1200

aacaattata agaccacccc tcccgtcctc gacagcgacg gatccttctt tctgtactcc     1260

aggctgaccg tggataagtc caggtggcag gaaggcaacg tgttcagctg ctccgtgatg     1320

cacgaggccc tgcacaatca ctacacccag aagtccctga gcctgtccct gggaaag        1377


<210>  441
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  441

Ser Ser Asp Val Gly Asp Tyr Asn Tyr 
1               5                   


<210>  442
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  442

Lys Ser Tyr Ala Gly Ser Asn Asn Leu Val 
1               5                   10  


<210>  443
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  443

Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  444
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  444

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  445
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  445
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt gattataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc aagtcatatg caggcagcaa caatttggtg      300

ttcggcggag ggaccaaact gaccgtccta                                       330


<210>  446
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  446

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  447
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  447
cagtctgccc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt gattataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc aagtcatatg caggcagcaa caatttggtg      300

ttcggcggag ggaccaaact gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  448
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  448

Ile Ser Tyr Asp Gly Ser Lys Lys 
1               5               


<210>  449
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  449

Ala Lys Glu Gly Tyr Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   10              


<210>  450
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  450

Asn Phe Asp Met Asp 
1               5   


<210>  451
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  451

Leu Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  452
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  452

Glu Gly Tyr Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   10      


<210>  453
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  453

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Asp Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Glu Gly Tyr Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  454
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  454
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactttgaca tggactgggt ccgccaggct      120

ccaggcaggg ggctggagtg ggtggcactt atatcatatg atggaagtaa aaaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagtctgag aggtgaggac acggctgtat atttctgtgc gaaagaggga      300

tatggtggct acgatggatt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  455
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  455

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Asp Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Glu Gly Tyr Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  456
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  456
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactttgaca tggactgggt ccgccaggct      120

ccaggcaggg ggctggagtg ggtggcactt atatcatatg atggaagtaa aaaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagtctgag aggtgaggac acggctgtat atttctgtgc gaaagaggga      300

tatggtggct acgatggatt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360

gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa      420

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      540

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      600

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      660

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      720

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      780

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      840

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      900

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa     1020

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag     1140

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc     1200

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc     1260

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgagcctgt ccctgggaaa g                                               1341


<210>  457
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  457

Thr Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210>  458
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  458

Tyr Asp Tyr 
1           


<210>  459
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  459

Ser Thr Trp Asp Asp Gly Leu Asn Gly Val Val 
1               5                   10      


<210>  460
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  460

Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  461
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  461

Tyr Asp Tyr Val Val Ser Ser 
1               5           


<210>  462
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  462

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Val Val Ser Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Gly Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  463
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  463
cagtctgtgc tgactcagcc accctcggta tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcacctc caacatcggc aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctct tatgattatg tggtgtcctc aggggtctct      180

gaccgcttct caggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgcggatg aggctgatta ttactgttca acatgggatg acggcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  464
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  464

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Val Val Ser Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Gly Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  465
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  465
cagtctgtgc tgactcagcc accctcggta tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcacctc caacatcggc aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctct tatgattatg tggtgtcctc aggggtctct      180

gaccgcttct caggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgcggatg aggctgatta ttactgttca acatgggatg acggcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta ggacagccaa aagcagcccc atccgtaact      360

ctgttcccac ctagttcaga ggagcttcaa gcaaacaaag ccacacttgt ttgccttatt      420

agtgattttt atcccggtgc cgtgacagtt gcctggaaag ctgatagctc accagtgaaa      480

gctggcgtgg agacaaccac accatctaaa caaagcaata acaagtatgc tgccagctca      540

tatctgagtc tcactccaga acaatggaag tctcatcggt cctatagctg tcaagtgacc      600

cacgaaggca gtaccgtcga gaagaccgtg gcaccaacag agtgtagc                   648


<210>  466
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  466

Gly Gly Ala Ile Ser Ser Ser Asn Tyr Phe 
1               5                   10  


<210>  467
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  467

Met Tyr Tyr Thr Gly Ile Thr 
1               5           


<210>  468
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  468

Ala Arg Gln Asp Gly Phe Arg Thr Gly Trp Phe Asp Pro 
1               5                   10              


<210>  469
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  469

Ser Ser Asn Tyr Phe Trp Gly 
1               5           


<210>  470
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  470

Ser Met Tyr Tyr Thr Gly Ile Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  471
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  471

Gln Asp Gly Phe Arg Thr Gly Trp Phe Asp Pro 
1               5                   10      


<210>  472
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  472

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ala Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Phe Trp Gly Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Tyr Tyr Thr Gly Ile Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Asp Gly Phe Arg Thr Gly Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  473
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  473
cagctgcagc ttcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg cgccatcagc agtagtaatt acttttgggg ctggatccgc      120

cagtccccag ggaaggggct ggagtggatt gggagtatgt attatactgg gatcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccaactc      240

tccctgaagg tgaattctgt gaccgccgca gacacggctg tttactactg tgcgagacaa      300

gatggattca gaacggggtg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  474
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  474

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ala Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Phe Trp Gly Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Tyr Tyr Thr Gly Ile Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Asp Gly Phe Arg Thr Gly Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  475
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  475
cagctgcagc ttcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg cgccatcagc agtagtaatt acttttgggg ctggatccgc      120

cagtccccag ggaaggggct ggagtggatt gggagtatgt attatactgg gatcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccaactc      240

tccctgaagg tgaattctgt gaccgccgca gacacggctg tttactactg tgcgagacaa      300

gatggattca gaacggggtg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tcagccagca ccaagggccc ttccgtgttc cccctggccc cttgcagcag gagcacctcc      420

gaatccacag ctgccctggg ctgtctggtg aaggactact ttcccgagcc cgtgaccgtg      480

agctggaaca gcggcgctct gacatccggc gtccacacct ttcctgccgt cctgcagtcc      540

tccggcctct actccctgtc ctccgtggtg accgtgccta gctcctccct cggcaccaag      600

acctacacct gtaacgtgga ccacaaaccc tccaacacca aggtggacaa acgggtcgag      660

agcaagtacg gccctccctg ccctccttgt cctgcccccg agttcgaagg cggacccagc      720

gtgttcctgt tccctcctaa gcccaaggac accctcatga tcagccggac acccgaggtg      780

acctgcgtgg tggtggatgt gagccaggag gaccctgagg tccagttcaa ctggtatgtg      840

gatggcgtgg aggtgcacaa cgccaagaca aagccccggg aagagcagtt caactccacc      900

tacagggtgg tcagcgtgct gaccgtgctg catcaggact ggctgaacgg caaggagtac      960

aagtgcaagg tcagcaataa gggactgccc agcagcatcg agaagaccat ctccaaggct     1020

aaaggccagc cccgggaacc tcaggtgtac accctgcctc ccagccagga ggagatgacc     1080

aagaaccagg tgagcctgac ctgcctggtg aagggattct acccttccga catcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aattataaga ccacccctcc cgtcctcgac     1200

agcgacggat ccttctttct gtactccagg ctgaccgtgg ataagtccag gtggcaggaa     1260

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1320

tccctgagcc tgtccctggg aaag                                            1344


<210>  476
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  476

Lys Leu Gly Asp Asn Tyr 
1               5       


<210>  477
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  477

Gln Asp Thr 
1           


<210>  478
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  478

Gln Ala Trp Asp Ser Arg Thr Val Val 
1               5                   


<210>  479
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  479

Ser Gly Asp Lys Leu Gly Asp Asn Tyr Val Cys 
1               5                   10      


<210>  480
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  480

Gln Asp Thr Lys Arg Pro Ser 
1               5           


<210>  481
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  481

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Ser Gly Asp Lys Leu Gly Asp Asn Tyr Val 
            20                  25                  30          


Cys Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Leu Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Leu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Arg Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  482
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  482
tcctatgaac tgactcagcc accctccgtg tccgtgtccc caggacagac agccaccctc       60

acctgctctg gagataaatt gggggataac tatgtttgct ggtttcagca aaagccaggc      120

cagtcccctc tgttggtcat gtatcaagat accaagcggc cctcagggat ccctgagcga      180

ttctcgggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctttg      240

gatgaggctg actattactg tcaggcgtgg gacagccgca ctgtggtttt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  483
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  483

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Ser Gly Asp Lys Leu Gly Asp Asn Tyr Val 
            20                  25                  30          


Cys Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Leu Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Leu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Arg Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  484
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  484
tcctatgaac tgactcagcc accctccgtg tccgtgtccc caggacagac agccaccctc       60

acctgctctg gagataaatt gggggataac tatgtttgct ggtttcagca aaagccaggc      120

cagtcccctc tgttggtcat gtatcaagat accaagcggc cctcagggat ccctgagcga      180

ttctcgggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctttg      240

gatgaggctg actattactg tcaggcgtgg gacagccgca ctgtggtttt cggcggaggg      300

accaagctga ccgtcctagg acagccaaaa gcagccccat ccgtaactct gttcccacct      360

agttcagagg agcttcaagc aaacaaagcc acacttgttt gccttattag tgatttttat      420

cccggtgccg tgacagttgc ctggaaagct gatagctcac cagtgaaagc tggcgtggag      480

acaaccacac catctaaaca aagcaataac aagtatgctg ccagctcata tctgagtctc      540

actccagaac aatggaagtc tcatcggtcc tatagctgtc aagtgaccca cgaaggcagt      600

accgtcgaga agaccgtggc accaacagag tgtagc                                636


<210>  485
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  485

Gly Tyr Thr Phe Ser Ser Phe Gly 
1               5               


<210>  486
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  486

Ile Ser Ala Tyr Asn Gly Ile Ser 
1               5               


<210>  487
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  487

Ala Arg Asp Arg Ala Asn Arg Asp Ala Leu Asp Val 
1               5                   10          


<210>  488
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  488

Ser Phe Gly Ile Thr 
1               5   


<210>  489
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  489

Trp Ile Ser Ala Tyr Asn Gly Ile Ser Asn Ser Ala Gln Lys Val Gln 
1               5                   10                  15      


Gly 
    


<210>  490
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  490

Asp Arg Ala Asn Arg Asp Ala Leu Asp Val 
1               5                   10  


<210>  491
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  491

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Ile Thr Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Ile Ser Asn Ser Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Asn Arg Asp Ala Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Lys Val Thr Val Ser Leu 
        115                 


<210>  492
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  492
caggttcaac tggtgcaatc tggagctgag gtgaggaagc ctggggccgc agtgaaggtc       60

tcctgcaagg cttctggtta caccttttcc agctttggta tcacctggat acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtat ctcaaactct      180

gcacagaagg tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggaactga ggagcctgag atctgacgac tcggccgtat attactgtgc gagagatcgg      300

gcgaataggg atgctcttga tgtctggggc caagggacaa aggtcaccgt ctcttta         357


<210>  493
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  493

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Ile Thr Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Ile Ser Asn Ser Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Asn Arg Asp Ala Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Lys Val Thr Val Ser Leu Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  494
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  494
caggttcaac tggtgcaatc tggagctgag gtgaggaagc ctggggccgc agtgaaggtc       60

tcctgcaagg cttctggtta caccttttcc agctttggta tcacctggat acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtat ctcaaactct      180

gcacagaagg tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggaactga ggagcctgag atctgacgac tcggccgtat attactgtgc gagagatcgg      300

gcgaataggg atgctcttga tgtctggggc caagggacaa aggtcaccgt ctctttagcc      360

agcaccaagg gcccttccgt gttccccctg gccccttgca gcaggagcac ctccgaatcc      420

acagctgccc tgggctgtct ggtgaaggac tactttcccg agcccgtgac cgtgagctgg      480

aacagcggcg ctctgacatc cggcgtccac acctttcctg ccgtcctgca gtcctccggc      540

ctctactccc tgtcctccgt ggtgaccgtg cctagctcct ccctcggcac caagacctac      600

acctgtaacg tggaccacaa accctccaac accaaggtgg acaaacgggt cgagagcaag      660

tacggccctc cctgccctcc ttgtcctgcc cccgagttcg aaggcggacc cagcgtgttc      720

ctgttccctc ctaagcccaa ggacaccctc atgatcagcc ggacacccga ggtgacctgc      780

gtggtggtgg atgtgagcca ggaggaccct gaggtccagt tcaactggta tgtggatggc      840

gtggaggtgc acaacgccaa gacaaagccc cgggaagagc agttcaactc cacctacagg      900

gtggtcagcg tgctgaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc      960

aaggtcagca ataagggact gcccagcagc atcgagaaga ccatctccaa ggctaaaggc     1020

cagccccggg aacctcaggt gtacaccctg cctcccagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaaggga ttctaccctt ccgacatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaattat aagaccaccc ctcccgtcct cgacagcgac     1200

ggatccttct ttctgtactc caggctgacc gtggataagt ccaggtggca ggaaggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc tgggaaag                                                   1338


<210>  495
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  495

Glu Leu Gly Asp Arg Tyr 
1               5       


<210>  496
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  496

Ser Gly Asp Glu Leu Gly Asp Arg Tyr Ala Cys 
1               5                   10      


<210>  497
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  497

Ser His Glu Leu Thr Gln Pro Pro Ser Met Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Glu Leu Gly Asp Arg Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ile Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  498
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  498
tcccatgaac tgactcagcc accctcaatg tccgtgtccc caggacagac tgccagcatc       60

acctgctctg gagatgaatt gggggataga tatgcttgct ggtatcaaca gaagccaggc      120

cagtcccctg tactggtcat ctatcaagat accaagcggc cctcagggat ccctgagcga      180

ttctctggct ccatctctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg      300

accaagttga ccgtccta                                                    318


<210>  499
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  499

Ser His Glu Leu Thr Gln Pro Pro Ser Met Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Glu Leu Gly Asp Arg Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ile Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  500
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  500
tcccatgaac tgactcagcc accctcaatg tccgtgtccc caggacagac tgccagcatc       60

acctgctctg gagatgaatt gggggataga tatgcttgct ggtatcaaca gaagccaggc      120

cagtcccctg tactggtcat ctatcaagat accaagcggc cctcagggat ccctgagcga      180

ttctctggct ccatctctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg      300

accaagttga ccgtcctagg acagccaaaa gcagccccat ccgtaactct gttcccacct      360

agttcagagg agcttcaagc aaacaaagcc acacttgttt gccttattag tgatttttat      420

cccggtgccg tgacagttgc ctggaaagct gatagctcac cagtgaaagc tggcgtggag      480

acaaccacac catctaaaca aagcaataac aagtatgctg ccagctcata tctgagtctc      540

actccagaac aatggaagtc tcatcggtcc tatagctgtc aagtgaccca cgaaggcagt      600

accgtcgaga agaccgtggc accaacagag tgtagc                                636


<210>  501
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  501

Gly Asp Ser Ile Ser Ser His Thr Tyr Trp 
1               5                   10  


<210>  502
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Phe Tyr Ser Gly Ser Thr 
1               5           


<210>  503
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  503

Ala Arg His Asn Asn Trp Gly Met Glu Asn Tyr Phe Asp Asp 
1               5                   10                  


<210>  504
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  504

Ser His Thr Tyr Trp Trp Gly 
1               5           


<210>  505
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  505

Ser Met Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  506
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  506

His Asn Asn Trp Gly Met Glu Asn Tyr Phe Asp Asp 
1               5                   10          


<210>  507
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  507

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser His 
            20                  25                  30          


Thr Tyr Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Val Ile Ser Val Asp Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Arg Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr 
                85                  90                  95      


Cys Ala Arg His Asn Asn Trp Gly Met Glu Asn Tyr Phe Asp Asp Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  508
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  508
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccatcagt agtcatactt actggtgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatgt tttatagtgg gagcacctac      180

tacaatccgt ccctcaagag tcgagtcgtc atatccgtag acacgtccag gaaccagttc      240

tccctgaaag tgaggtctgt gaccgccgca gacacggctg tgttttactg tgcgagacat      300

aataattggg gaatggagaa ctactttgac gactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  509
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  509

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser His 
            20                  25                  30          


Thr Tyr Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Val Ile Ser Val Asp Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Arg Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr 
                85                  90                  95      


Cys Ala Arg His Asn Asn Trp Gly Met Glu Asn Tyr Phe Asp Asp Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  510
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  510
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccatcagt agtcatactt actggtgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatgt tttatagtgg gagcacctac      180

tacaatccgt ccctcaagag tcgagtcgtc atatccgtag acacgtccag gaaccagttc      240

tccctgaaag tgaggtctgt gaccgccgca gacacggctg tgttttactg tgcgagacat      300

aataattggg gaatggagaa ctactttgac gactggggcc agggaaccct ggtcaccgtc      360

tcctcagcca gcaccaaggg cccttccgtg ttccccctgg ccccttgcag caggagcacc      420

tccgaatcca cagctgccct gggctgtctg gtgaaggact actttcccga gcccgtgacc      480

gtgagctgga acagcggcgc tctgacatcc ggcgtccaca cctttcctgc cgtcctgcag      540

tcctccggcc tctactccct gtcctccgtg gtgaccgtgc ctagctcctc cctcggcacc      600

aagacctaca cctgtaacgt ggaccacaaa ccctccaaca ccaaggtgga caaacgggtc      660

gagagcaagt acggccctcc ctgccctcct tgtcctgccc ccgagttcga aggcggaccc      720

agcgtgttcc tgttccctcc taagcccaag gacaccctca tgatcagccg gacacccgag      780

gtgacctgcg tggtggtgga tgtgagccag gaggaccctg aggtccagtt caactggtat      840

gtggatggcg tggaggtgca caacgccaag acaaagcccc gggaagagca gttcaactcc      900

acctacaggg tggtcagcgt gctgaccgtg ctgcatcagg actggctgaa cggcaaggag      960

tacaagtgca aggtcagcaa taagggactg cccagcagca tcgagaagac catctccaag     1020

gctaaaggcc agccccggga acctcaggtg tacaccctgc ctcccagcca ggaggagatg     1080

accaagaacc aggtgagcct gacctgcctg gtgaagggat tctacccttc cgacatcgcc     1140

gtggagtggg agtccaacgg ccagcccgag aacaattata agaccacccc tcccgtcctc     1200

gacagcgacg gatccttctt tctgtactcc aggctgaccg tggataagtc caggtggcag     1260

gaaggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag     1320

aagtccctga gcctgtccct gggaaag                                         1347


<210>  511
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  511

Gln Ser Ala Asp Ser Ser Gly Ser Tyr Val Val 
1               5                   10      


<210>  512
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  512

Ser Ala Asp Ala Leu Pro Asp Gln Tyr Gly Tyr 
1               5                   10      


<210>  513
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  513

Ser Tyr Ala Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Pro Asp Gln Tyr Gly 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Ser Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  514
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  514
tcctatgcgc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg cagatgcatt gccagaccaa tatggttact ggtaccagca gaagccaggc      120

caggcccctg tgctggtgat atataaagac agtgagaggc cctcagggat ccctgagcgg      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcagtg gttcttatgt ggtattcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  515
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  515

Ser Tyr Ala Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Pro Asp Gln Tyr Gly 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Ser Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  516
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  516
tcctatgcgc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg cagatgcatt gccagaccaa tatggttact ggtaccagca gaagccaggc      120

caggcccctg tgctggtgat atataaagac agtgagaggc cctcagggat ccctgagcgg      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcagtg gttcttatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggacag ccaaaagcag ccccatccgt aactctgttc      360

ccacctagtt cagaggagct tcaagcaaac aaagccacac ttgtttgcct tattagtgat      420

ttttatcccg gtgccgtgac agttgcctgg aaagctgata gctcaccagt gaaagctggc      480

gtggagacaa ccacaccatc taaacaaagc aataacaagt atgctgccag ctcatatctg      540

agtctcactc cagaacaatg gaagtctcat cggtcctata gctgtcaagt gacccacgaa      600

ggcagtaccg tcgagaagac cgtggcacca acagagtgta gc                         642


<210>  517
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  517
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  518
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  518

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  519
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  519
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  520
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  520

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  521
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  521
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  522
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  522

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  523
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  523
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acatcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  524
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  524

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  525
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  525
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agtggagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cgcgggggca      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  526
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  526

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  527
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  527
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  528
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  528

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  529
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  529
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgacctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

atggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt cgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  530
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  530

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  531
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  531
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  532
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  532

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  533
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  533
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt cgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatctc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  534
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  534

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  535
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  535
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  536
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  536

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  537
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  537
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccgtgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcgtgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  538
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  538

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  539
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  539
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcaggagggg      900

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  540
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  540

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  541
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  541
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacggccg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcgcctgaat ttgagggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtca tcgatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggatcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  542
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  542
gcctccacca agggacctag cgtgttccct ctcgccccct gttccaggtc cacaagcgag       60

tccaccgctg ccctcggctg tctggtgaaa gactactttc ccgagcccgt gaccgtctcc      120

tggaatagcg gagccctgac ctccggcgtg cacacatttc ccgccgtgct gcagagcagc      180

ggactgtata gcctgagcag cgtggtgacc gtgcccagct ccagcctcgg caccaaaacc      240

tacacctgca acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggagagc      300

aagtacggcc ccccttgccc tccttgtcct gcccctgagt tcgagggagg accctccgtg      360

ttcctgtttc cccccaaacc caaggacacc ctgatgatct cccggacacc cgaggtgacc      420

tgtgtggtcg tggacgtcag ccaggaggac cccgaggtgc agttcaactg gtatgtggac      480

ggcgtggagg tgcacaatgc caaaaccaag cccagggagg agcagttcaa ttccacctac      540

agggtggtga gcgtgctgac cgtcctgcat caggattggc tgaacggcaa ggagtacaag      600

tgcaaggtgt ccaacaaggg actgcccagc tccatcgaga agaccatcag caaggctaag      660

ggccagccga gggagcccca ggtgtatacc ctgcctccta gccaggaaga gatgaccaag      720

aaccaagtgt ccctgacctg cctggtgaag ggattctacc cctccgacat cgccgtggag      780

tgggagagca atggccagcc cgagaacaac tacaaaacaa cccctcccgt gctcgatagc      840

gacggcagct tctttctcta cagccggctg acagtggaca agagcaggtg gcaggagggc      900

aacgtgttct cctgttccgt gatgcacgag gccctgcaca atcactacac ccagaagagc      960

ctctccctgt ccctgggcaa g                                                981


<210>  543
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  543
gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa       60

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      120

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      180

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      240

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      300

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      360

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      420

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      480

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      540

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa      660

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag      720

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag      780

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc      840

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc      900

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc      960

ctgagcctgt ccctgggaaa g                                                981


<210>  544
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  544

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  545
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  545
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacggccg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcgcctccag ttgcgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtca tcgatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggatcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  546
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  546

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  547
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  547
cgtacggtgg ccgctccctc cgtgttcatc ttcccacctt ccgacgagca gctgaagtcc       60

ggcaccgctt ctgtcgtgtg cctgctgaac aacttctacc cccgcgaggc caaggtgcag      120

tggaaggtgg acaacgccct gcagtccggc aactcccagg aatccgtgac cgagcaggac      180

tccaaggaca gcacctactc cctgtcctcc accctgaccc tgtccaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaagtgacc caccagggcc tgtctagccc cgtgaccaag      300

tctttcaacc ggggcgagtg t                                                321


<210>  548
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  548

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  549
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  549
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggag      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgccgg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  550
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  550

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Glu Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Gly Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  551
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  551
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

cggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggag      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  552
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  552

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Arg Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Glu Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  553
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  553
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  554
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  554

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  555
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  555
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcaac accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg c                                                321


<210>  556
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  556

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  557
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  557
cccaaggcca accccacggt cactctgttc ccgccctcct ctgaggagct ccaagccaac       60

aaggccacac tagtgtgtct gatcagtgac ttctacccgg gagctgtgac agtggcttgg      120

aaggcagatg gcagccccgt caaggcggga gtggagacga ccaaaccctc caaacagagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac      240

agaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      300

acagaatgtt ca                                                          312


<210>  558
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  558

Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210>  559
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  559
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  560
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  560
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  561
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  561

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  562
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  562
ggccagccta aggccgctcc ttctgtgacc ctgttccccc catcctccga ggaactgcag       60

gctaacaagg ccaccctcgt gtgcctgatc agcgacttct accctggcgc cgtgaccgtg      120

gcctggaagg ctgatagctc tcctgtgaag gccggcgtgg aaaccaccac cccttccaag      180

cagtccaaca acaaatacgc cgcctcctcc tacctgtccc tgacccctga gcagtggaag      240

tcccaccggt cctacagctg ccaagtgacc cacgagggct ccaccgtgga aaagaccgtg      300

gctcctaccg agtgctcc                                                    318


<210>  563
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  563
ggccagccta aagctgcccc cagcgtcacc ctgtttcctc cctccagcga ggagctccag       60

gccaacaagg ccaccctcgt gtgcctgatc tccgacttct atcccggcgc tgtgaccgtg      120

gcttggaaag ccgactccag ccctgtcaaa gccggcgtgg agaccaccac accctccaag      180

cagtccaaca acaagtacgc cgcctccagc tatctctccc tgacccctga gcagtggaag      240

tcccaccggt cctactcctg tcaggtgacc cacgagggct ccaccgtgga aaagaccgtc      300

gcccccaccg agtgctcc                                                    318


<210>  564
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  564

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  565
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  565
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  566
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  566
cccaaggctg ccccctcggt cactctgttc ccaccctcct ctgaggagct tcaagccaac       60

aaggccacac tggtgtgtct cataagtgac ttctacccgg gagccgtgac agttgcctgg      120

aaggcagata gcagccccgt caaggcgggg gtggagacca ccacaccctc caaacaaagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ctgagcagtg gaagtcccac      240

aaaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agttgcccct      300

acggaatgtt ca                                                          312


<210>  567
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  567

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210>  568
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  568
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccggggcc agtgacagtt      120

gcctggaagg cagatagcag ccccgtcaag gcgggggtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacgg aatgttca                                                    318


<210>  569
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  569

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Pro Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  570
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  570
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  571
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  571

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  572
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  572
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  573
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  573
ggtcagccca aggctgcccc atcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgcctgatc agtgacttct acccgggagc tgtgaaagtg      120

gcctggaagg cagatggcag ccccgtcaac acgggagtgg agaccaccac accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgttca                                                    318


<210>  574
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  574

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  575
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  575
ggtcagccca aggctgcccc atcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  576
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  576

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  577
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  577
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttca acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  578
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  578

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Asn Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  579
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  579
gcttctacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag       60

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtct      120

tggaactctg gcgctctgac atctggcgtg cacacattcc ctgctgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      240

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      300

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttgaaggcgg cccttccgtg      360

tttctgttcc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      420

tgcgtggtgg tggatgtgtc ccaagaggat cccgaggtgc agttcaattg gtacgtggac      480

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      540

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      600

tgcaaggtgt ccaacaaggg cctgcctagc tccatcgaaa agaccatctc caaggccaag      660

ggccagcctc gagaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag      720

aaccaggtgt ccctgacctg cctcgtgaag ggattctacc cctccgatat cgccgtggaa      780

tgggagtcta atggccagcc agagaacaac tacaagacaa cccctcctgt gctggactcc      840

gacggctcct tctttctgta ttcccgcctg accgtggaca agtccagatg gcaagagggc      900

aacgtgttct cctgcagcgt gatgcacgag gccctgcaca atcactacac ccagaagtcc      960

ctgtctctgt ccctgggc                                                    978


<210>  580
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  580

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


