                         SEQUENCE LISTING

<110>  RAMOT AT TEL-AVIV UNIVERSITY LTD.
       YEDA RESEARCH AND DEVELOPMENT CO. LTD
       ICHILOV TECH LTD
 
<120>  CHIMERIC ANTIGEN RECEPTOR TO CARBOHYDRATE ANTIGENS

<130>  RAMOT-092 PCT

<150>  62940274
<151>  2019-11-26

<150>  63069051
<151>  2020-08-23

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  2
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  2

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  3

Lys Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Pro Ala 
        115 


<210>  4
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  5

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  6

Gly Phe Thr Phe Ser Asp Ala Trp Met Asp 
1               5                   10  


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  7

Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Lys Gly 
1               5                   10                  15      


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  8

Arg Phe Ala Tyr 
1               


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  9

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  10

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  11

Leu Gln Tyr Asp Glu Phe Pro Arg Thr Phe 
1               5                   10  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  12

Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu Ser Val Lys Gly 
1               5                   10                  15      


<210>  13
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  13
aaagtcaagc tagaagaaag cggtggcgga cttgttcagc ctgggggatc catgaagtta       60

tcttgcgccg catccggttt taccttttct gatgcctgga tggattgggt gagacaatct      120

ccagaaaaag gtctggaatg ggtagccgaa attggtaaca agggcaataa tcacgccacg      180

aactatgccg agtctgtaaa aggaagattc actgtttcca gagacgattc aaagtccaga      240

gtctatctac aaatgaattc attaagagtc gaagatactg gtacttacta ctgtaccact      300

aggtttgcat attggggtca aggtacaccg gtgacggttc ctgcc                      345


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  14
gacattaaaa tgactcagag tccatcctca atgtacgctt ccttaggaga aagagtcact       60

atcccttgca aggcatccca agatatcaac tcatacttga gttggttcca acaaaaacca      120

ggtaaatctc ctaaaaccct gatttatcgt gccaataggc ttgtggatgg cgttccatcc      180

agattcagcg gatcaggtag tgggcaagat tattctttga caatttcctc attggaatac      240

gaagatatgg gcatatacta ttgcttacag tatgatgagt ttccacgtac ttttggcggt      300

ggaacaaaat tagaaatcaa a                                                321


<210>  15
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Lys Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser 
    130                 135                 140                 


Leu Gly Glu Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn 
145                 150                 155                 160 


Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr 
                165                 170                 175     


Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe 
    210                 215                 220                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235         


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Gly Gly Gly Gly Ser 
1               5   


<210>  17
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105                 110 


<210>  18
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
1               5                   10                  15      


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
            20                  25                  30          


His Glu Lys Pro Pro Gln 
        35              


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  20
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Lys Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Gly Asn Lys Gly Asn Asn His 
65                  70                  75                  80  


Ala Thr Asn Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Arg Val Tyr Leu Gln Met Asn Ser Leu Arg Val 
            100                 105                 110         


Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Pro Val Thr Val Pro Ala Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Pro Cys Lys 
                165                 170                 175     


Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln Tyr Asp Glu Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
            260                 265                 270         


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    290                 295                 300                 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gln Val Arg Lys Ala 
    370                 375                 380                 


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
385                 390                 395                 400 


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
                405                 410                 415     


Gln 
    


<210>  21
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21
aaagtcaagc tagaagaaag cggtggcgga cttgttcagc ctgggggatc catgaagtta       60

tcttgcgccg catccggttt taccttttct gatgcctgga tggattgggt gagacaatct      120

ccagaaaaag gtctggaatg ggtagccgaa attggtaaca agggcaataa tcacgccacg      180

aactatgccg agtctgtaaa aggaagattc actgtttcca gagacgattc aaagtccaga      240

gtctatctac aaatgaattc attaagagtc gaagatactg gtacttacta ctgtaccact      300

aggtttgcat attggggtca aggtacaccg gtgacggttc ctgccggagg tggcggtagc      360

ggaggcggcg gttctggagg tggcgggagc gacattaaaa tgactcagag tccatcctca      420

atgtacgctt ccttaggaga aagagtcact atcccttgca aggcatccca agatatcaac      480

tcatacttga gttggttcca acaaaaacca ggtaaatctc ctaaaaccct gatttatcgt      540

gccaataggc ttgtggatgg cgttccatcc agattcagcg gatcaggtag tgggcaagat      600

tattctttga caatttcctc attggaatac gaagatatgg gcatatacta ttgcttacag      660

tatgatgagt ttccacgtac ttttggcggt ggaacaaaat tagaaatcaa a               711


<210>  22
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      300

ccaccacgcg acttcgcagc ctatagatct                                       330


<210>  23
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23
caagtgcgaa aggcagctat aaccagctat gagaaatcag atggtgttta cacgggcctg       60

agcaccagga accaggagac ttacgagact ctgaagcatg agaaaccacc acagtag         117


<210>  24
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agagga                                                                  66


<210>  25
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggaaaag tcaagctaga agaaagcggt ggcggacttg ttcagcctgg gggatccatg      120

aagttatctt gcgccgcatc cggttttacc ttttctgatg cctggatgga ttgggtgaga      180

caatctccag aaaaaggtct ggaatgggta gccgaaattg gtaacaaggg caataatcac      240

gccacgaact atgccgagtc tgtaaaagga agattcactg tttccagaga cgattcaaag      300

tccagagtct atctacaaat gaattcatta agagtcgaag atactggtac ttactactgt      360

accactaggt ttgcatattg gggtcaaggt acaccggtga cggttcctgc cggaggtggc      420

ggtagcggag gcggcggttc tggaggtggc gggagcgaca ttaaaatgac tcagagtcca      480

tcctcaatgt acgcttcctt aggagaaaga gtcactatcc cttgcaaggc atcccaagat      540

atcaactcat acttgagttg gttccaacaa aaaccaggta aatctcctaa aaccctgatt      600

tatcgtgcca ataggcttgt ggatggcgtt ccatccagat tcagcggatc aggtagtggg      660

caagattatt ctttgacaat ttcctcattg gaatacgaag atatgggcat atactattgc      720

ttacagtatg atgagtttcc acgtactttt ggcggtggaa caaaattaga aatcaaaggt      780

ggaggtggat ccggtggagg tggatccgcg gccgcaattg aagttatgta tcctcctcct      840

tacctagaca atgagaagag caatggaacc attatccatg tgaaagggaa acacctttgt      900

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      960

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1080

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tagatctcaa     1140

gtgcgaaagg cagctataac cagctatgag aaatcagatg gtgtttacac gggcctgagc     1200

accaggaacc aggagactta cgagactctg aagcatgaga aaccaccaca gtag           1254


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27
tggagccacc cgcagttcga gaaa                                              24


<210>  28
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Lys Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Gly Asn Lys Gly Asn Asn His 
65                  70                  75                  80  


Ala Thr Asn Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Arg Val Tyr Leu Gln Met Asn Ser Leu Arg Val 
            100                 105                 110         


Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Pro Val Thr Val Pro Ala Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Pro Cys Lys 
                165                 170                 175     


Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln Tyr Asp Glu Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
385                 390                 395                 400 


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
                405                 410                 415     


Thr Leu Lys His Glu Lys Pro Pro Gln 
            420                 425 


<210>  29
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggaaaag tcaagctaga agaaagcggt ggcggacttg ttcagcctgg gggatccatg      120

aagttatctt gcgccgcatc cggttttacc ttttctgatg cctggatgga ttgggtgaga      180

caatctccag aaaaaggtct ggaatgggta gccgaaattg gtaacaaggg caataatcac      240

gccacgaact atgccgagtc tgtaaaagga agattcactg tttccagaga cgattcaaag      300

tccagagtct atctacaaat gaattcatta agagtcgaag atactggtac ttactactgt      360

accactaggt ttgcatattg gggtcaaggt acaccggtga cggttcctgc cggaggtggc      420

ggtagcggag gcggcggttc tggaggtggc gggagcgaca ttaaaatgac tcagagtcca      480

tcctcaatgt acgcttcctt aggagaaaga gtcactatcc cttgcaaggc atcccaagat      540

atcaactcat acttgagttg gttccaacaa aaaccaggta aatctcctaa aaccctgatt      600

tatcgtgcca ataggcttgt ggatggcgtt ccatccagat tcagcggatc aggtagtggg      660

caagattatt ctttgacaat ttcctcattg gaatacgaag atatgggcat atactattgc      720

ttacagtatg atgagtttcc acgtactttt ggcggtggaa caaaattaga aatcaaatgg      780

agccacccgc agttcgagaa aggtggaggt ggatccggtg gaggtggatc cgcggccgca      840

attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc      900

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      960

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     1020

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatagatc tcaagtgcga aaggcagcta taaccagcta tgagaaatca     1200

gatggtgttt acacgggcct gagcaccagg aaccaggaga cttacgagac tctgaagcat     1260

gagaaaccac cacagtag                                                   1278


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  30

Asp Ala Trp Met Asp 
1               5   


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  31

Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  32

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  33

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  35
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35
ggaggtggcg gtagcggagg cggcggttct ggaggtggcg ggagc                       45


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  36

Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  37
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser 
    130                 135                 140                 


Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn 
145                 150                 155                 160 


Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr 
                165                 170                 175     


Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe 
    210                 215                 220                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235         


<210>  38
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  38

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Glu Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Gly Asn Lys Gly Asn Asn His 
65                  70                  75                  80  


Ala Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Arg Val Tyr Leu Gln Met Asn Ser Leu Arg Val 
            100                 105                 110         


Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys 
                165                 170                 175     


Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln Tyr Asp Glu Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
            260                 265                 270         


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    290                 295                 300                 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gln Val Arg Lys Ala 
    370                 375                 380                 


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
385                 390                 395                 400 


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
                405                 410                 415     


Gln 
    


<210>  39
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  39

Lys Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  40
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  40

Lys Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  41

Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Glu Ile 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  42

Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  43

Trp Gly Gln Gly Thr Pro Val Thr Val Pro Ala 
1               5                   10      


<210>  44
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  44

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Pro Cys 
            20              


<210>  45
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  45

Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  46

Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr 
1               5                   10                  15  


<210>  47
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  47

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  48

Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   


