                         SEQUENCE LISTING

<110>  REGENXBIO Inc.
 
<120>  MICRODYSTROPHIN GENE THERAPY CONSTRUCTS AND USES THEREOF

<130>  38013.0009P1

<150>  63/024,933
<151>  2020-05-14

<150>  62/941,719
<151>  2019-11-28

<160>  127   

<170>  PatentIn version 3.5

<210>  1
<211>  1337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; micro dystrophin protein

<400>  1

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Gln Pro Asp Leu Ala 
            660                 665                 670         


Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu 
        675                 680                 685             


Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu 
    690                 695                 700                 


Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr Leu Glu Arg Leu Gln 
705                 710                 715                 720 


Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala 
                725                 730                 735     


Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp 
            740                 745                 750         


Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile 
        755                 760                 765             


Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln 
    770                 775                 780                 


Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu 
785                 790                 795                 800 


Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 
                805                 810                 815     


Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser 
            820                 825                 830         


Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile 
        835                 840                 845             


Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr 
    850                 855                 860                 


Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp 
865                 870                 875                 880 


Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg 
                885                 890                 895     


Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala 
            900                 905                 910         


Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met 
        915                 920                 925             


Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 
    930                 935                 940                 


Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met 
945                 950                 955                 960 


Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg 
                965                 970                 975     


Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala 
            980                 985                 990         


His Leu Glu Asp Lys Tyr Arg Tyr  Leu Phe Lys Gln Val  Ala Ser Ser 
        995                 1000                 1005             


Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly Leu Leu  Leu His Asp 
    1010                 1015                 1020             


Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu Val Ala  Ser Phe Gly 
    1025                 1030                 1035             


Gly Ser  Asn Ile Glu Pro Ser  Val Arg Ser Cys Phe  Gln Phe Ala 
    1040                 1045                 1050             


Asn Asn  Lys Pro Glu Ile Glu  Ala Ala Leu Phe Leu  Asp Trp Met 
    1055                 1060                 1065             


Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu Pro Val  Leu His Arg 
    1070                 1075                 1080             


Val Ala  Ala Ala Glu Thr Ala  Lys His Gln Ala Lys  Cys Asn Ile 
    1085                 1090                 1095             


Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys 
    1100                 1105                 1110             


His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg 
    1115                 1120                 1125             


Val Ala  Lys Gly His Lys Met  His Tyr Pro Met Val  Glu Tyr Cys 
    1130                 1135                 1140             


Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val 
    1145                 1150                 1155             


Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro 
    1160                 1165                 1170             


Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn 
    1175                 1180                 1185             


Met Glu  Thr Pro Val Thr Leu  Ile Asn Phe Trp Pro  Val Asp Ser 
    1190                 1195                 1200             


Ala Pro  Ala Ser Ser Pro Gln  Leu Ser His Asp Asp  Thr His Ser 
    1205                 1210                 1215             


Arg Ile  Glu His Tyr Ala Ser  Arg Leu Ala Glu Met  Glu Asn Ser 
    1220                 1225                 1230             


Asn Gly  Ser Tyr Leu Asn Asp  Ser Ile Ser Pro Asn  Glu Ser Ile 
    1235                 1240                 1245             


Asp Asp  Glu His Leu Leu Ile  Gln His Tyr Cys Gln  Ser Leu Asn 
    1250                 1255                 1260             


Gln Asp  Ser Pro Leu Ser Gln  Pro Arg Ser Pro Ala  Gln Ile Leu 
    1265                 1270                 1275             


Ile Ser  Leu Glu Ser Glu Glu  Arg Gly Glu Leu Glu  Arg Ile Leu 
    1280                 1285                 1290             


Ala Asp  Leu Glu Glu Glu Asn  Arg Asn Leu Gln Ala  Glu Tyr Asp 
    1295                 1300                 1305             


Arg Leu  Lys Gln Gln His Glu  His Lys Gly Leu Ser  Pro Leu Pro 
    1310                 1315                 1320             


Ser Pro  Pro Glu Met Met Pro  Thr Ser Pro Gln Ser  Pro Arg 
    1325                 1330                 1335         


<210>  2
<211>  1191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; micro dystrophin protein

<400>  2

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Gln Pro Asp Leu Ala 
            660                 665                 670         


Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu 
        675                 680                 685             


Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu 
    690                 695                 700                 


Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr Leu Glu Arg Leu Gln 
705                 710                 715                 720 


Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala 
                725                 730                 735     


Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp 
            740                 745                 750         


Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile 
        755                 760                 765             


Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln 
    770                 775                 780                 


Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu 
785                 790                 795                 800 


Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 
                805                 810                 815     


Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser 
            820                 825                 830         


Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile 
        835                 840                 845             


Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr 
    850                 855                 860                 


Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp 
865                 870                 875                 880 


Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg 
                885                 890                 895     


Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala 
            900                 905                 910         


Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met 
        915                 920                 925             


Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 
    930                 935                 940                 


Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met 
945                 950                 955                 960 


Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg 
                965                 970                 975     


Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala 
            980                 985                 990         


His Leu Glu Asp Lys Tyr Arg Tyr  Leu Phe Lys Gln Val  Ala Ser Ser 
        995                 1000                 1005             


Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly Leu Leu  Leu His Asp 
    1010                 1015                 1020             


Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu Val Ala  Ser Phe Gly 
    1025                 1030                 1035             


Gly Ser  Asn Ile Glu Pro Ser  Val Arg Ser Cys Phe  Gln Phe Ala 
    1040                 1045                 1050             


Asn Asn  Lys Pro Glu Ile Glu  Ala Ala Leu Phe Leu  Asp Trp Met 
    1055                 1060                 1065             


Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu Pro Val  Leu His Arg 
    1070                 1075                 1080             


Val Ala  Ala Ala Glu Thr Ala  Lys His Gln Ala Lys  Cys Asn Ile 
    1085                 1090                 1095             


Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys 
    1100                 1105                 1110             


His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg 
    1115                 1120                 1125             


Val Ala  Lys Gly His Lys Met  His Tyr Pro Met Val  Glu Tyr Cys 
    1130                 1135                 1140             


Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val 
    1145                 1150                 1155             


Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro 
    1160                 1165                 1170             


Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn 
    1175                 1180                 1185             


Met Glu  Thr 
    1190     


<210>  3
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  3

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  4

Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu 
1               5                   10          


<210>  5
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  5

Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu 
1               5                   10                  15      


His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln 
            20                  25                  30          


Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala 
        35                  40                  45              


Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro 
    50                  55                  60                  


Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp 
65                  70                  75  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  6

Lys Ser Phe Gly Ser Ser Leu Met Glu 
1               5                   


<210>  7
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  7

Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
1               5                   10                  15      


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
            20                  25                  30          


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
        35                  40                  45              


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
    50                  55                  60                  


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
65                  70                  75                  80  


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
                85                  90                  95      


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg 
            100                 105                 110     


<210>  8
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  8

Val Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp 
1               5                   10                  15      


Leu Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu 
            20                  25                  30          


Gly Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val 
        35                  40                  45              


Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr 
    50                  55                  60                  


His Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala 
65                  70                  75                  80  


Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile 
                85                  90                  95      


Cys Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp 
            100                 105                 


<210>  9
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  9

Ile Leu 
1       


<210>  10
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  10

Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp 
1               5                   10                  15      


Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe 
            20                  25                  30          


Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu 
        35                  40                  45              


Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser 
    50                  55                  60                  


Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln 
65                  70                  75                  80  


Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu 
                85                  90                  95      


Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln 
            100                 105                 


<210>  11
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  11

Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr 
1               5                   10                  15      


Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala 
            20                  25                  30          


Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro 
        35                  40                  45          


<210>  12
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  12

Thr Leu Glu 
1           


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  13

Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 
1               5                   10                  15      


Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 
        35                  40                  45              


Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu 
    50                  55                  60                  


Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala 
                85                  90                  95      


Val Glu Asp Arg Val Arg Gln Leu His Glu 
            100                 105     


<210>  14
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  14

Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
1               5                   10                  15      


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            20                  25                  30          


Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met 
        35                  40                  45              


Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 
    50                  55                  60                  


Ala Tyr Arg Thr Ala Met Lys Leu 
65                  70          


<210>  15
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  15

Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala 
1               5                   10                  15      


Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro 
            20                  25                  30          


Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg 
        35                  40                  45              


Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 
    50                  55                  60                  


Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys 
                85                  90                  95      


Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser 
            100                 105                 110         


Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp 
        115                 120                 125             


Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly 
    130                 135                 140                 


Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn 
145                 150                 155                 160 


Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 
                165                 170                 175     


Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala 
            180                 185                 190         


Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro 
        195                 200                 205             


Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile 
    210                 215                 220                 


Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met 
225                 230                 235                 240 


His Tyr Pro Met Val Glu Tyr Cys 
                245             


<210>  16
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  16

Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu 
1               5                   10                  15      


Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met 
            20                  25                  30          


Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 
        35                  40                  45              


Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser 
    50                  55                  60                  


Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr 
65                  70                  75                  80  


Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn 
                85                  90                  95      


Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile 
            100                 105                 110         


Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro 
        115                 120                 125             


Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly 
    130                 135                 140                 


Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu 
145                 150                 155                 160 


Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu 
                165                 170                 175     


Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser 
            180                 185                 190         


Pro Arg 
        


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  17

Glu Thr Leu Glu 
1               


<210>  18
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  18

Leu Glu 
1       


<210>  19
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  19

Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val Thr 
1               5                   10                  15      


Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp 
        35                  40                  


<210>  20
<211>  4017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  20
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaagtgt ccattgaggc cattcaagag gttgagatgc tgcccagacc tcctaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcacagtg      840

tctctggccc agggatatga gagaacaagc agccccaagc ctaggttcaa gagctatgcc      900

tacacacagg ctgcctatgt gaccacatct gaccccacaa gaagcccatt tccaagccag      960

catctggaag cccctgagga caagagcttt ggcagcagcc tgatggaatc tgaagtgaac     1020

ctggatagat accagacagc cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat     1080

acactgcagg ctcagggtga aatcagcaat gatgtggaag tggtcaagga ccagtttcac     1140

acccatgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg aaatatcctg     1200

cagctgggct ccaagctgat tggcacaggc aagctgtctg aggatgaaga gacagaggtg     1260

caagagcaga tgaacctgct gaacagcaga tgggagtgtc tgagagtggc cagcatggaa     1320

aagcagagca acctgcacag agtgctcatg gacctgcaga atcagaaact gaaagaactg     1380

aatgactggc tgaccaagac agaagaaagg actaggaaga tggaagagga acctctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcata aggtgctgca agaggacctt     1500

gagcaagagc aagtcagagt gaacagcctg acacacatgg tggtggttgt ggatgagtcc     1560

tctggggatc atgccacagc tgctctggaa gaacagctga aggtgctggg agacagatgg     1620

gccaacatct gtaggtggac agaggataga tgggtgctgc tccaggacat tctgctgaag     1680

tggcagagac tgacagagga acagtgcctg ttttctgcct ggctctctga gaaagaggat     1740

gctgtcaaca agatccatac cacaggcttc aaggatcaga atgagatgct cagctccctg     1800

cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa agcagtccat gggcaagctc     1860

tacagcctga agcaggacct gctgtctacc ctgaagaaca agtctgtgac ccagaaaact     1920

gaggcctggc tggacaactt tgctagatgc tgggacaacc tggtgcagaa gctggaaaag     1980

tctacagccc agatcagcca gcaacctgat cttgcccctg gcctgaccac aattggagcc     2040

tctccaacac agactgtgac cctggttacc cagccagtgg tcaccaaaga gacagccatc     2100

agcaaactgg aaatgcccag ctctctgatg ctggaagtcc ccacactgga aaggctgcaa     2160

gaacttcaag aggccacaga tgagctggac ctgaagctga gacaggctga agtgatcaaa     2220

ggcagctggc agccagttgg ggacctgctc attgatagcc tgcaggacca tctggaaaaa     2280

gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa atgtgtccca tgtgaatgac     2340

ctggccagac agctgaccac actgggaatc cagctgagcc cctacaacct gagcaccctt     2400

gaggacctga acaccaggtg gaagctcctc caggtggcag tggaagatag agtcaggcag     2460

ctgcatgagg cccacagaga ttttggacca gccagccagc actttctgtc tacctctgtg     2520

caaggcccct gggagagagc tatctctcct aacaaggtgc cctactacat caaccatgag     2580

acacagacca cctgttggga tcaccccaag atgacagagc tgtaccagag tctggcagac     2640

ctcaacaatg tcagattcag tgcctacagg actgccatga agctcagaag gctccagaaa     2700

gctctgtgcc tggacctgct ttccctgagt gcagcttgtg atgccctgga ccagcacaat     2760

ctgaagcaga atgaccagcc tatggacatc ctccagatca tcaactgcct caccaccatc     2820

tatgataggc tggaacaaga gcacaacaat ctggtcaatg tgcccctgtg tgtggacatg     2880

tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa caggcaggat cagagtcctg     2940

tccttcaaga caggcatcat ctccctgtgc aaagcccact tggaggacaa gtacagatac     3000

ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc agagaaggct gggcctgctc     3060

ctgcatgaca gcattcagat ccctagacag ctgggagaag tggcttcctt tggaggcagc     3120

aatattgagc catcagtcag gtcctgtttt cagtttgcca acaacaagcc tgagattgag     3180

gctgccctgt tcctggactg gatgagactt gagcctcaga gcatggtctg gctgcctgtg     3240

cttcatagag tggctgctgc tgagactgcc aagcaccagg ccaagtgcaa catctgcaaa     3300

gagtgcccca tcattggctt cagatacaga tccctgaagc acttcaacta tgatatctgc     3360

cagagctgct tctttagtgg cagggttgcc aagggccaca aaatgcacta ccccatggtg     3420

gaatactgca ccccaacaac ctctggggaa gatgttagag actttgccaa ggtgctgaaa     3480

aacaagttca ggaccaagag atactttgct aagcacccca gaatgggcta cctgcctgtc     3540

cagacagtgc ttgagggtga caacatggaa acccctgtga cactgatcaa tttctggcca     3600

gtggactctg cccctgcctc aagtccacag ctgtcccatg atgacaccca cagcagaatt     3660

gagcactatg cctccagact ggcagagatg gaaaacagca atggcagcta cctgaatgat     3720

agcatcagcc ccaatgagag cattgatgat gagcatctgc tgatccagca ctactgtcag     3780

tccctgaacc aggactctcc actgagccag cctagaagcc ctgctcagat cctgatcagc     3840

cttgagtctg aggaaagggg agagctggaa agaatcctgg cagatcttga ggaagagaac     3900

agaaacctgc aggcagagta tgacaggctc aaacagcagc atgagcacaa gggactgagc     3960

cctctgcctt ctcctcctga aatgatgccc acctctccac agtctccaag gtgatga        4017


<210>  21
<211>  3573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  21
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaagtgt ccattgaggc cattcaagag gttgagatgc tgcccagacc tcctaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcacagtg      840

tctctggccc agggatatga gagaacaagc agccccaagc ctaggttcaa gagctatgcc      900

tacacacagg ctgcctatgt gaccacatct gaccccacaa gaagcccatt tccaagccag      960

catctggaag cccctgagga caagagcttt ggcagcagcc tgatggaatc tgaagtgaac     1020

ctggatagat accagacagc cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat     1080

acactgcagg ctcagggtga aatcagcaat gatgtggaag tggtcaagga ccagtttcac     1140

acccatgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg aaatatcctg     1200

cagctgggct ccaagctgat tggcacaggc aagctgtctg aggatgaaga gacagaggtg     1260

caagagcaga tgaacctgct gaacagcaga tgggagtgtc tgagagtggc cagcatggaa     1320

aagcagagca acctgcacag agtgctcatg gacctgcaga atcagaaact gaaagaactg     1380

aatgactggc tgaccaagac agaagaaagg actaggaaga tggaagagga acctctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcata aggtgctgca agaggacctt     1500

gagcaagagc aagtcagagt gaacagcctg acacacatgg tggtggttgt ggatgagtcc     1560

tctggggatc atgccacagc tgctctggaa gaacagctga aggtgctggg agacagatgg     1620

gccaacatct gtaggtggac agaggataga tgggtgctgc tccaggacat tctgctgaag     1680

tggcagagac tgacagagga acagtgcctg ttttctgcct ggctctctga gaaagaggat     1740

gctgtcaaca agatccatac cacaggcttc aaggatcaga atgagatgct cagctccctg     1800

cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa agcagtccat gggcaagctc     1860

tacagcctga agcaggacct gctgtctacc ctgaagaaca agtctgtgac ccagaaaact     1920

gaggcctggc tggacaactt tgctagatgc tgggacaacc tggtgcagaa gctggaaaag     1980

tctacagccc agatcagcca gcaacctgat cttgcccctg gcctgaccac aattggagcc     2040

tctccaacac agactgtgac cctggttacc cagccagtgg tcaccaaaga gacagccatc     2100

agcaaactgg aaatgcccag ctctctgatg ctggaagtcc ccacactgga aaggctgcaa     2160

gaacttcaag aggccacaga tgagctggac ctgaagctga gacaggctga agtgatcaaa     2220

ggcagctggc agccagttgg ggacctgctc attgatagcc tgcaggacca tctggaaaaa     2280

gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa atgtgtccca tgtgaatgac     2340

ctggccagac agctgaccac actgggaatc cagctgagcc cctacaacct gagcaccctt     2400

gaggacctga acaccaggtg gaagctcctc caggtggcag tggaagatag agtcaggcag     2460

ctgcatgagg cccacagaga ttttggacca gccagccagc actttctgtc tacctctgtg     2520

caaggcccct gggagagagc tatctctcct aacaaggtgc cctactacat caaccatgag     2580

acacagacca cctgttggga tcaccccaag atgacagagc tgtaccagag tctggcagac     2640

ctcaacaatg tcagattcag tgcctacagg actgccatga agctcagaag gctccagaaa     2700

gctctgtgcc tggacctgct ttccctgagt gcagcttgtg atgccctgga ccagcacaat     2760

ctgaagcaga atgaccagcc tatggacatc ctccagatca tcaactgcct caccaccatc     2820

tatgataggc tggaacaaga gcacaacaat ctggtcaatg tgcccctgtg tgtggacatg     2880

tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa caggcaggat cagagtcctg     2940

tccttcaaga caggcatcat ctccctgtgc aaagcccact tggaggacaa gtacagatac     3000

ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc agagaaggct gggcctgctc     3060

ctgcatgaca gcattcagat ccctagacag ctgggagaag tggcttcctt tggaggcagc     3120

aatattgagc catcagtcag gtcctgtttt cagtttgcca acaacaagcc tgagattgag     3180

gctgccctgt tcctggactg gatgagactt gagcctcaga gcatggtctg gctgcctgtg     3240

cttcatagag tggctgctgc tgagactgcc aagcaccagg ccaagtgcaa catctgcaaa     3300

gagtgcccca tcattggctt cagatacaga tccctgaagc acttcaacta tgatatctgc     3360

cagagctgct tctttagtgg cagggttgcc aagggccaca aaatgcacta ccccatggtg     3420

gaatactgca ccccaacaac ctctggggaa gatgttagag actttgccaa ggtgctgaaa     3480

aacaagttca ggaccaagag atactttgct aagcacccca gaatgggcta cctgcctgtc     3540

cagacagtgc ttgagggtga caacatggaa acc                                  3573


<210>  22
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  22
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  23
caacaagtga gcattgaagc catccaggaa gtggaa                                 36


<210>  24
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  24
atgttgccaa ggccacctaa agtgactaaa gaagaacatt ttcagttaca tcatcaaatg       60

cactattctc aacagatcac ggtcagtcta gcacagggat atgagagaac ttcttcccct      120

aagcctcgat tcaagagcta tgcctacaca caggctgctt atgtcaccac ctctgaccct      180

acacggagcc catttccttc acagcatttg gaagctcctg aagac                      225


<210>  25
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  25
aagtcatttg gcagttcatt gatggag                                           27


<210>  26
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  26
agtgaagtaa acctggaccg ttatcaaaca gctttagaag aagtattatc gtggcttctt       60

tctgctgagg acacattgca agcacaagga gagatttcta atgatgtgga agtggtgaaa      120

gaccagtttc atactcatga ggggtacatg atggatttga cagcccatca gggccgggtt      180

ggtaatattc tacaattggg aagtaagctg attggaacag gaaaattatc agaagatgaa      240

gaaactgaag tacaagagca gatgaatctc ctaaattcaa gatgggaatg cctcagggta      300

gctagcatgg aaaaacaaag caatttacat aga                                   333


<210>  27
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  27
gttttaatgg atctccagaa tcagaaactg aaagagttga atgactggct aacaaaaaca       60

gaagaaagaa caaggaaaat ggaggaagag cctcttggac ctgatcttga agacctaaaa      120

cgccaagtac aacaacataa ggtgcttcaa gaagatctag aacaagaaca agtcagggtc      180

aattctctca ctcacatggt ggtggtagtt gatgaatcta gtggagatca cgcaactgct      240

gctttggaag aacaacttaa ggtattggga gatcgatggg caaacatctg tagatggaca      300

gaagaccgct gggttctttt acaagac                                          327


<210>  28
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  28
atcctt                                                                   6


<210>  29
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  29
ctcaaatggc aacgtcttac tgaagaacag tgccttttta gtgcatggct ttcagaaaaa       60

gaagatgcag tgaacaagat tcacacaact ggctttaaag atcaaaatga aatgttatca      120

agtcttcaaa aactggccgt tttaaaagcg gatctagaaa agaaaaagca atccatgggc      180

aaactgtatt cactcaaaca agatcttctt tcaacactga agaataagtc agtgacccag      240

aagacggaag catggctgga taactttgcc cggtgttggg ataatttagt ccaaaaactt      300

gaaaagagta cagcacagat ttcacag                                          327


<210>  30
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  30
cagcctgacc tagctcctgg actgaccact attggagcct ctcctactca gactgttact       60

ctggtgacac aacctgtggt tactaaggaa actgccatct ccaaactaga aatgccatct      120

tccttgatgt tggaggtacc t                                                141


<210>  31
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  31
acccttgaa                                                                9


<210>  32
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  32
agactccaac ttcaagaggc cacggatgag ctggacctca agctgcgcca agctgaggtg       60

atcaagggat cctggcagcc cgtgggcgat ctcctcattg actctctcca agatcacctc      120

gagaaagtca aggcacttcg aggagaaatt gcgcctctga aagagaacgt gagccacgtc      180

aatgaccttg ctcgccagct taccactttg ggcattcagc tctcaccgta taacctcagc      240

actctggaag acctgaacac cagatggaag cttctgcagg tggccgtcga ggaccgagtc      300

aggcagctgc atgaa                                                       315


<210>  33
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  33
gcccacaggg actttggtcc agcatctcag cactttcttt ccacgtctgt ccagggtccc       60

tgggagagag ccatctcgcc aaacaaagtg ccctactata tcaaccacga gactcaaaca      120

acttgctggg accatcccaa aatgacagag ctctaccagt ctttagctga cctgaataat      180

gtcagattct cagcttatag gactgccatg aaactc                                216


<210>  34
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  34
cgaagactgc agaaggccct ttgcttggat ctcttgagcc tgtcagctgc atgtgatgcc       60

ttggaccagc acaacctcaa gcaaaatgac cagcccatgg atatcctgca gattattaat      120

tgtttgacca ctatttatga ccgcctggag caagagcaca acaatttggt caacgtccct      180

ctctgcgtgg atatgtgtct gaactggctg ctgaatgttt atgatacggg acgaacaggg      240

aggatccgtg tcctgtcttt taaaactggc atcatttccc tgtgtaaagc acatttggaa      300

gacaagtaca gatacctttt caagcaagtg gcaagttcaa caggattttg tgaccagcgc      360

aggctgggcc tccttctgca tgattctatc caaattccaa gacagttggg tgaagttgca      420

tcctttgggg gcagtaacat tgagccaagt gtccggagct gcttccaatt tgctaataat      480

aagccagaga tcgaagcggc cctcttccta gactggatga gactggaacc ccagtccatg      540

gtgtggctgc ccgtcctgca cagagtggct gctgcagaaa ctgccaagca tcaggccaaa      600

tgtaacatct gcaaagagtg tccaatcatt ggattcaggt acaggagtct aaagcacttt      660

aattatgaca tctgccaaag ctgctttttt tctggtcgag ttgcaaaagg ccataaaatg      720

cactatccca tggtggaata ttgc                                             744


<210>  35
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  35
actccgacta catcaggaga agatgttcga gactttgcca aggtactaaa aaacaaattt       60

cgaaccaaaa ggtattttgc gaagcatccc cgaatgggct acctgccagt gcagactgtc      120

ttagaggggg acaacatgga aactcccgtt actctgatca acttctggcc agtagattct      180

gcgcctgcct cgtcccctca gctttcacac gatgatactc attcacgcat tgaacattat      240

gctagcaggc tagcagaaat ggaaaacagc aatggatctt atctaaatga tagcatctct      300

cctaatgaga gcatagatga tgaacatttg ttaatccagc attactgcca aagtttgaac      360

caggactccc ccctgagcca gcctcgtagt cctgcccaga tcttgatttc cttagagagt      420

gaggaaagag gggagctaga gagaatccta gcagatcttg aggaagaaaa caggaatctg      480

caagcagaat atgaccgtct aaagcagcag cacgaacata aaggcctgtc cccactgccg      540

tcccctcctg aaatgatgcc cacctctccc cagagtcccc gg                         582


<210>  36
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  36
gagacccttg aa                                                           12


<210>  37
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  37
cttgaa                                                                   6


<210>  38
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  38
ccatcactaa cacagacaac tgtaatggaa acagtaacta cggtgaccac aagggaacag       60

atcctggtaa agcatgctca agaggaactt ccaccaccac ctccccaaaa gaagaggcag      120

attactgtgg at                                                          132


<210>  39
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  39
ggccgtccgc cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg       60

tggggagtta tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa      120

aaataactcc cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac      180

ggttcctcac ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg      240

gccgggcggt gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag      300

ctacccggag gagcgggagg cgccaagc                                         328


<210>  40
<211>  173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  40
aatggtggac acccaaatat ggcgacggtt cctcacccgt cgccatattt gggtgtccgc       60

cctcggccgg ggccgcattc ctgggggccg ggcggtgctc ccgcccgcct cgataaaagg      120

ctccggggcc ggcggcggcc cacgagctac ccggaggagc gggaggcgcc aag             173


<210>  41
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; intron

<400>  41
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc                  50


<210>  42
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; poly A

<400>  42
aggcctaata aagagctcag atgcatcgat cagagtgtgt tggttttttg                  50


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  43
tgactcgaga ggcctaataa agagc                                             25


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  44
gtggagaggt gtcagaggtt cc                                                22


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  45
ggcccacgag ctacccggag                                                   20


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  46
cttccagcag atccagcagc c                                                 21


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  47
aagggacctt taccagtgat gtg                                               23


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  48
acttactctc gccttcctcg g                                                 21


<210>  49
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; probe

<400>  49
cagcaaagga attca                                                        15


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  50
tgggcctgct cctgcatg                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  51
atctcaggct tggcaaac                                                     18


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; proble

<400>  52
caatattgag ccatcagtc                                                    19


<210>  53
<211>  4734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  53
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaagcgga attcgccacc atgctttggt gggaagaggt ggaagattgc tatgagaggg      540

aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc ccagttcagc aagtttggca      600

agcagcacat tgagaacctg ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc      660

tggaaggcct gacaggccag aagctgccta aagagaaggg cagcacaaga gtgcatgccc      720

tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa caatgtggac ctggtcaata      780

ttggcagcac agacattgtg gatggcaacc acaagctgac cctgggcctg atctggaaca      840

tcatcctgca ctggcaagtg aagaatgtga tgaagaacat catggctggc ctgcagcaga      900

ccaactctga gaagatcctg ctgagctggg tcagacagag caccagaaac taccctcaag      960

tgaatgtgat caacttcacc acctcttgga gtgatggact ggccctgaat gccctgatcc     1020

acagccacag acctgacctg tttgactgga actctgttgt gtgccagcag tctgccacac     1080

agagactgga acatgccttc aacattgcca gataccagct gggaattgag aaactgctgg     1140

accctgagga tgtggacacc acctatcctg acaagaaatc catcctcatg tacatcacca     1200

gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc cattcaagag gttgagatgc     1260

tgcccagacc tcctaaagtg accaaagagg aacacttcca gctgcaccac cagatgcact     1320

actctcagca gatcacagtg tctctggccc agggatatga gagaacaagc agccccaagc     1380

ctaggttcaa gagctatgcc tacacacagg ctgcctatgt gaccacatct gaccccacaa     1440

gaagcccatt tccaagccag catctggaag cccctgagga caagagcttt ggcagcagcc     1500

tgatggaatc tgaagtgaac ctggatagat accagacagc cctggaagaa gtgctgtcct     1560

ggctgctgtc tgctgaggat acactgcagg ctcagggtga aatcagcaat gatgtggaag     1620

tggtcaagga ccagtttcac acccatgagg gctacatgat ggacctgaca gcccaccagg     1680

gcagagtggg aaatatcctg cagctgggct ccaagctgat tggcacaggc aagctgtctg     1740

aggatgaaga gacagaggtg caagagcaga tgaacctgct gaacagcaga tgggagtgtc     1800

tgagagtggc cagcatggaa aagcagagca acctgcacag agtgctcatg gacctgcaga     1860

atcagaaact gaaagaactg aatgactggc tgaccaagac agaagaaagg actaggaaga     1920

tggaagagga acctctggga ccagacctgg aagatctgaa aagacaggtg cagcagcata     1980

aggtgctgca agaggacctt gagcaagagc aagtcagagt gaacagcctg acacacatgg     2040

tggtggttgt ggatgagtcc tctggggatc atgccacagc tgctctggaa gaacagctga     2100

aggtgctggg agacagatgg gccaacatct gtaggtggac agaggataga tgggtgctgc     2160

tccaggacat tctgctgaag tggcagagac tgacagagga acagtgcctg ttttctgcct     2220

ggctctctga gaaagaggat gctgtcaaca agatccatac cacaggcttc aaggatcaga     2280

atgagatgct cagctccctg cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa     2340

agcagtccat gggcaagctc tacagcctga agcaggacct gctgtctacc ctgaagaaca     2400

agtctgtgac ccagaaaact gaggcctggc tggacaactt tgctagatgc tgggacaacc     2460

tggtgcagaa gctggaaaag tctacagccc agatcagcca gcaacctgat cttgcccctg     2520

gcctgaccac aattggagcc tctccaacac agactgtgac cctggttacc cagccagtgg     2580

tcaccaaaga gacagccatc agcaaactgg aaatgcccag ctctctgatg ctggaagtcc     2640

ccacactgga aaggctgcaa gaacttcaag aggccacaga tgagctggac ctgaagctga     2700

gacaggctga agtgatcaaa ggcagctggc agccagttgg ggacctgctc attgatagcc     2760

tgcaggacca tctggaaaaa gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa     2820

atgtgtccca tgtgaatgac ctggccagac agctgaccac actgggaatc cagctgagcc     2880

cctacaacct gagcaccctt gaggacctga acaccaggtg gaagctcctc caggtggcag     2940

tggaagatag agtcaggcag ctgcatgagg cccacagaga ttttggacca gccagccagc     3000

actttctgtc tacctctgtg caaggcccct gggagagagc tatctctcct aacaaggtgc     3060

cctactacat caaccatgag acacagacca cctgttggga tcaccccaag atgacagagc     3120

tgtaccagag tctggcagac ctcaacaatg tcagattcag tgcctacagg actgccatga     3180

agctcagaag gctccagaaa gctctgtgcc tggacctgct ttccctgagt gcagcttgtg     3240

atgccctgga ccagcacaat ctgaagcaga atgaccagcc tatggacatc ctccagatca     3300

tcaactgcct caccaccatc tatgataggc tggaacaaga gcacaacaat ctggtcaatg     3360

tgcccctgtg tgtggacatg tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa     3420

caggcaggat cagagtcctg tccttcaaga caggcatcat ctccctgtgc aaagcccact     3480

tggaggacaa gtacagatac ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc     3540

agagaaggct gggcctgctc ctgcatgaca gcattcagat ccctagacag ctgggagaag     3600

tggcttcctt tggaggcagc aatattgagc catcagtcag gtcctgtttt cagtttgcca     3660

acaacaagcc tgagattgag gctgccctgt tcctggactg gatgagactt gagcctcaga     3720

gcatggtctg gctgcctgtg cttcatagag tggctgctgc tgagactgcc aagcaccagg     3780

ccaagtgcaa catctgcaaa gagtgcccca tcattggctt cagatacaga tccctgaagc     3840

acttcaacta tgatatctgc cagagctgct tctttagtgg cagggttgcc aagggccaca     3900

aaatgcacta ccccatggtg gaatactgca ccccaacaac ctctggggaa gatgttagag     3960

actttgccaa ggtgctgaaa aacaagttca ggaccaagag atactttgct aagcacccca     4020

gaatgggcta cctgcctgtc cagacagtgc ttgagggtga caacatggaa acccctgtga     4080

cactgatcaa tttctggcca gtggactctg cccctgcctc aagtccacag ctgtcccatg     4140

atgacaccca cagcagaatt gagcactatg cctccagact ggcagagatg gaaaacagca     4200

atggcagcta cctgaatgat agcatcagcc ccaatgagag cattgatgat gagcatctgc     4260

tgatccagca ctactgtcag tccctgaacc aggactctcc actgagccag cctagaagcc     4320

ctgctcagat cctgatcagc cttgagtctg aggaaagggg agagctggaa agaatcctgg     4380

cagatcttga ggaagagaac agaaacctgc aggcagagta tgacaggctc aaacagcagc     4440

atgagcacaa gggactgagc cctctgcctt ctcctcctga aatgatgccc acctctccac     4500

agtctccaag gtgatgactc gagaggccta ataaagagct cagatgcatc gatcagagtg     4560

tgttggtttt ttgtgtgcca gggtaatggg ctagctgcgg ccgcaggaac ccctagtgat     4620

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     4680

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           4734


<210>  54
<211>  4814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  54
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaaggtga gtatctcagg gatccagaca tggggatatg ggaggtgcct ctgatcccag      540

ggctcactgt gggtctctct gttcacagga attcgccacc atgctttggt gggaagaggt      600

ggaagattgc tatgagaggg aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc      660

ccagttcagc aagtttggca agcagcacat tgagaacctg ttcagtgacc tgcaggatgg      720

cagaaggctg ctggatctgc tggaaggcct gacaggccag aagctgccta aagagaaggg      780

cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa      840

caatgtggac ctggtcaata ttggcagcac agacattgtg gatggcaacc acaagctgac      900

cctgggcctg atctggaaca tcatcctgca ctggcaagtg aagaatgtga tgaagaacat      960

catggctggc ctgcagcaga ccaactctga gaagatcctg ctgagctggg tcagacagag     1020

caccagaaac taccctcaag tgaatgtgat caacttcacc acctcttgga gtgatggact     1080

ggccctgaat gccctgatcc acagccacag acctgacctg tttgactgga actctgttgt     1140

gtgccagcag tctgccacac agagactgga acatgccttc aacattgcca gataccagct     1200

gggaattgag aaactgctgg accctgagga tgtggacacc acctatcctg acaagaaatc     1260

catcctcatg tacatcacca gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc     1320

cattcaagag gttgagatgc tgcccagacc tcctaaagtg accaaagagg aacacttcca     1380

gctgcaccac cagatgcact actctcagca gatcacagtg tctctggccc agggatatga     1440

gagaacaagc agccccaagc ctaggttcaa gagctatgcc tacacacagg ctgcctatgt     1500

gaccacatct gaccccacaa gaagcccatt tccaagccag catctggaag cccctgagga     1560

caagagcttt ggcagcagcc tgatggaatc tgaagtgaac ctggatagat accagacagc     1620

cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat acactgcagg ctcagggtga     1680

aatcagcaat gatgtggaag tggtcaagga ccagtttcac acccatgagg gctacatgat     1740

ggacctgaca gcccaccagg gcagagtggg aaatatcctg cagctgggct ccaagctgat     1800

tggcacaggc aagctgtctg aggatgaaga gacagaggtg caagagcaga tgaacctgct     1860

gaacagcaga tgggagtgtc tgagagtggc cagcatggaa aagcagagca acctgcacag     1920

agtgctcatg gacctgcaga atcagaaact gaaagaactg aatgactggc tgaccaagac     1980

agaagaaagg actaggaaga tggaagagga acctctggga ccagacctgg aagatctgaa     2040

aagacaggtg cagcagcata aggtgctgca agaggacctt gagcaagagc aagtcagagt     2100

gaacagcctg acacacatgg tggtggttgt ggatgagtcc tctggggatc atgccacagc     2160

tgctctggaa gaacagctga aggtgctggg agacagatgg gccaacatct gtaggtggac     2220

agaggataga tgggtgctgc tccaggacat tctgctgaag tggcagagac tgacagagga     2280

acagtgcctg ttttctgcct ggctctctga gaaagaggat gctgtcaaca agatccatac     2340

cacaggcttc aaggatcaga atgagatgct cagctccctg cagaaactgg ctgtgctgaa     2400

ggctgacctg gaaaagaaaa agcagtccat gggcaagctc tacagcctga agcaggacct     2460

gctgtctacc ctgaagaaca agtctgtgac ccagaaaact gaggcctggc tggacaactt     2520

tgctagatgc tgggacaacc tggtgcagaa gctggaaaag tctacagccc agatcagcca     2580

gcaacctgat cttgcccctg gcctgaccac aattggagcc tctccaacac agactgtgac     2640

cctggttacc cagccagtgg tcaccaaaga gacagccatc agcaaactgg aaatgcccag     2700

ctctctgatg ctggaagtcc ccacactgga aaggctgcaa gaacttcaag aggccacaga     2760

tgagctggac ctgaagctga gacaggctga agtgatcaaa ggcagctggc agccagttgg     2820

ggacctgctc attgatagcc tgcaggacca tctggaaaaa gtgaaagccc tgaggggaga     2880

gattgcccct ctgaaagaaa atgtgtccca tgtgaatgac ctggccagac agctgaccac     2940

actgggaatc cagctgagcc cctacaacct gagcaccctt gaggacctga acaccaggtg     3000

gaagctcctc caggtggcag tggaagatag agtcaggcag ctgcatgagg cccacagaga     3060

ttttggacca gccagccagc actttctgtc tacctctgtg caaggcccct gggagagagc     3120

tatctctcct aacaaggtgc cctactacat caaccatgag acacagacca cctgttggga     3180

tcaccccaag atgacagagc tgtaccagag tctggcagac ctcaacaatg tcagattcag     3240

tgcctacagg actgccatga agctcagaag gctccagaaa gctctgtgcc tggacctgct     3300

ttccctgagt gcagcttgtg atgccctgga ccagcacaat ctgaagcaga atgaccagcc     3360

tatggacatc ctccagatca tcaactgcct caccaccatc tatgataggc tggaacaaga     3420

gcacaacaat ctggtcaatg tgcccctgtg tgtggacatg tgcctgaatt ggctgctgaa     3480

tgtgtatgac acaggcagaa caggcaggat cagagtcctg tccttcaaga caggcatcat     3540

ctccctgtgc aaagcccact tggaggacaa gtacagatac ctgttcaagc aagtggcctc     3600

cagcacaggc ttttgtgacc agagaaggct gggcctgctc ctgcatgaca gcattcagat     3660

ccctagacag ctgggagaag tggcttcctt tggaggcagc aatattgagc catcagtcag     3720

gtcctgtttt cagtttgcca acaacaagcc tgagattgag gctgccctgt tcctggactg     3780

gatgagactt gagcctcaga gcatggtctg gctgcctgtg cttcatagag tggctgctgc     3840

tgagactgcc aagcaccagg ccaagtgcaa catctgcaaa gagtgcccca tcattggctt     3900

cagatacaga tccctgaagc acttcaacta tgatatctgc cagagctgct tctttagtgg     3960

cagggttgcc aagggccaca aaatgcacta ccccatggtg gaatactgca ccccaacaac     4020

ctctggggaa gatgttagag actttgccaa ggtgctgaaa aacaagttca ggaccaagag     4080

atactttgct aagcacccca gaatgggcta cctgcctgtc cagacagtgc ttgagggtga     4140

caacatggaa acccctgtga cactgatcaa tttctggcca gtggactctg cccctgcctc     4200

aagtccacag ctgtcccatg atgacaccca cagcagaatt gagcactatg cctccagact     4260

ggcagagatg gaaaacagca atggcagcta cctgaatgat agcatcagcc ccaatgagag     4320

cattgatgat gagcatctgc tgatccagca ctactgtcag tccctgaacc aggactctcc     4380

actgagccag cctagaagcc ctgctcagat cctgatcagc cttgagtctg aggaaagggg     4440

agagctggaa agaatcctgg cagatcttga ggaagagaac agaaacctgc aggcagagta     4500

tgacaggctc aaacagcagc atgagcacaa gggactgagc cctctgcctt ctcctcctga     4560

aatgatgccc acctctccac agtctccaag gtgatgactc gagaggccta ataaagagct     4620

cagatgcatc gatcagagtg tgttggtttt ttgtgtgcca gggtaatggg ctagctgcgg     4680

ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4740

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4800

gagcgagcgc gcag                                                       4814


<210>  55
<211>  4364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  55
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaaggtga gtatctcagg gatccagaca tggggatatg ggaggtgcct ctgatcccag      540

ggctcactgt gggtctctct gttcacagga attcgccacc atgctttggt gggaagaggt      600

ggaagattgc tatgagaggg aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc      660

ccagttcagc aagtttggca agcagcacat tgagaacctg ttcagtgacc tgcaggatgg      720

cagaaggctg ctggatctgc tggaaggcct gacaggccag aagctgccta aagagaaggg      780

cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa      840

caatgtggac ctggtcaata ttggcagcac agacattgtg gatggcaacc acaagctgac      900

cctgggcctg atctggaaca tcatcctgca ctggcaagtg aagaatgtga tgaagaacat      960

catggctggc ctgcagcaga ccaactctga gaagatcctg ctgagctggg tcagacagag     1020

caccagaaac taccctcaag tgaatgtgat caacttcacc acctcttgga gtgatggact     1080

ggccctgaat gccctgatcc acagccacag acctgacctg tttgactgga actctgttgt     1140

gtgccagcag tctgccacac agagactgga acatgccttc aacattgcca gataccagct     1200

gggaattgag aaactgctgg accctgagga tgtggacacc acctatcctg acaagaaatc     1260

catcctcatg tacatcacca gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc     1320

cattcaagag gttgagatgc tgcccagacc tcctaaagtg accaaagagg aacacttcca     1380

gctgcaccac cagatgcact actctcagca gatcacagtg tctctggccc agggatatga     1440

gagaacaagc agccccaagc ctaggttcaa gagctatgcc tacacacagg ctgcctatgt     1500

gaccacatct gaccccacaa gaagcccatt tccaagccag catctggaag cccctgagga     1560

caagagcttt ggcagcagcc tgatggaatc tgaagtgaac ctggatagat accagacagc     1620

cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat acactgcagg ctcagggtga     1680

aatcagcaat gatgtggaag tggtcaagga ccagtttcac acccatgagg gctacatgat     1740

ggacctgaca gcccaccagg gcagagtggg aaatatcctg cagctgggct ccaagctgat     1800

tggcacaggc aagctgtctg aggatgaaga gacagaggtg caagagcaga tgaacctgct     1860

gaacagcaga tgggagtgtc tgagagtggc cagcatggaa aagcagagca acctgcacag     1920

agtgctcatg gacctgcaga atcagaaact gaaagaactg aatgactggc tgaccaagac     1980

agaagaaagg actaggaaga tggaagagga acctctggga ccagacctgg aagatctgaa     2040

aagacaggtg cagcagcata aggtgctgca agaggacctt gagcaagagc aagtcagagt     2100

gaacagcctg acacacatgg tggtggttgt ggatgagtcc tctggggatc atgccacagc     2160

tgctctggaa gaacagctga aggtgctggg agacagatgg gccaacatct gtaggtggac     2220

agaggataga tgggtgctgc tccaggacat tctgctgaag tggcagagac tgacagagga     2280

acagtgcctg ttttctgcct ggctctctga gaaagaggat gctgtcaaca agatccatac     2340

cacaggcttc aaggatcaga atgagatgct cagctccctg cagaaactgg ctgtgctgaa     2400

ggctgacctg gaaaagaaaa agcagtccat gggcaagctc tacagcctga agcaggacct     2460

gctgtctacc ctgaagaaca agtctgtgac ccagaaaact gaggcctggc tggacaactt     2520

tgctagatgc tgggacaacc tggtgcagaa gctggaaaag tctacagccc agatcagcca     2580

gcaacctgat cttgcccctg gcctgaccac aattggagcc tctccaacac agactgtgac     2640

cctggttacc cagccagtgg tcaccaaaga gacagccatc agcaaactgg aaatgcccag     2700

ctctctgatg ctggaagtcc ccacactgga aaggctgcaa gaacttcaag aggccacaga     2760

tgagctggac ctgaagctga gacaggctga agtgatcaaa ggcagctggc agccagttgg     2820

ggacctgctc attgatagcc tgcaggacca tctggaaaaa gtgaaagccc tgaggggaga     2880

gattgcccct ctgaaagaaa atgtgtccca tgtgaatgac ctggccagac agctgaccac     2940

actgggaatc cagctgagcc cctacaacct gagcaccctt gaggacctga acaccaggtg     3000

gaagctcctc caggtggcag tggaagatag agtcaggcag ctgcatgagg cccacagaga     3060

ttttggacca gccagccagc actttctgtc tacctctgtg caaggcccct gggagagagc     3120

tatctctcct aacaaggtgc cctactacat caaccatgag acacagacca cctgttggga     3180

tcaccccaag atgacagagc tgtaccagag tctggcagac ctcaacaatg tcagattcag     3240

tgcctacagg actgccatga agctcagaag gctccagaaa gctctgtgcc tggacctgct     3300

ttccctgagt gcagcttgtg atgccctgga ccagcacaat ctgaagcaga atgaccagcc     3360

tatggacatc ctccagatca tcaactgcct caccaccatc tatgataggc tggaacaaga     3420

gcacaacaat ctggtcaatg tgcccctgtg tgtggacatg tgcctgaatt ggctgctgaa     3480

tgtgtatgac acaggcagaa caggcaggat cagagtcctg tccttcaaga caggcatcat     3540

ctccctgtgc aaagcccact tggaggacaa gtacagatac ctgttcaagc aagtggcctc     3600

cagcacaggc ttttgtgacc agagaaggct gggcctgctc ctgcatgaca gcattcagat     3660

ccctagacag ctgggagaag tggcttcctt tggaggcagc aatattgagc catcagtcag     3720

gtcctgtttt cagtttgcca acaacaagcc tgagattgag gctgccctgt tcctggactg     3780

gatgagactt gagcctcaga gcatggtctg gctgcctgtg cttcatagag tggctgctgc     3840

tgagactgcc aagcaccagg ccaagtgcaa catctgcaaa gagtgcccca tcattggctt     3900

cagatacaga tccctgaagc acttcaacta tgatatctgc cagagctgct tctttagtgg     3960

cagggttgcc aagggccaca aaatgcacta ccccatggtg gaatactgca ccccaacaac     4020

ctctggggaa gatgttagag actttgccaa ggtgctgaaa aacaagttca ggaccaagag     4080

atactttgct aagcacccca gaatgggcta cctgcctgtc cagacagtgc ttgagggtga     4140

caacatggaa acctgatgag tcgacaggcc taataaagag ctcagatgca tcgatcagag     4200

tgtgttggtt ttttgtgtgg ctagctgcgg ccgcaggaac ccctagtgat ggagttggcc     4260

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4320

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag                      4364


<210>  56
<211>  4661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  56
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag aatggtggac acccaaatat      180

ggcgacggtt cctcacccgt cgccatattt gggtgtccgc cctcggccgg ggccgcattc      240

ctgggggccg ggcggtgctc ccgcccgcct cgataaaagg ctccggggcc ggcggcggcc      300

cacgagctac ccggaggagc gggaggcgcc aaggtgagta tctcagggat ccagacatgg      360

ggatatggga ggtgcctctg atcccagggc tcactgtggg tctctctgtt cacaggaatt      420

cgccaccatg ctttggtggg aagaggtgga agattgctat gagagggaag atgtgcagaa      480

gaaaaccttc accaaatggg tcaatgccca gttcagcaag tttggcaagc agcacattga      540

gaacctgttc agtgacctgc aggatggcag aaggctgctg gatctgctgg aaggcctgac      600

aggccagaag ctgcctaaag agaagggcag cacaagagtg catgccctga acaatgtgaa      660

caaggccctg agagtgctgc agaacaacaa tgtggacctg gtcaatattg gcagcacaga      720

cattgtggat ggcaaccaca agctgaccct gggcctgatc tggaacatca tcctgcactg      780

gcaagtgaag aatgtgatga agaacatcat ggctggcctg cagcagacca actctgagaa      840

gatcctgctg agctgggtca gacagagcac cagaaactac cctcaagtga atgtgatcaa      900

cttcaccacc tcttggagtg atggactggc cctgaatgcc ctgatccaca gccacagacc      960

tgacctgttt gactggaact ctgttgtgtg ccagcagtct gccacacaga gactggaaca     1020

tgccttcaac attgccagat accagctggg aattgagaaa ctgctggacc ctgaggatgt     1080

ggacaccacc tatcctgaca agaaatccat cctcatgtac atcaccagcc tgttccaggt     1140

gctgccccag caagtgtcca ttgaggccat tcaagaggtt gagatgctgc ccagacctcc     1200

taaagtgacc aaagaggaac acttccagct gcaccaccag atgcactact ctcagcagat     1260

cacagtgtct ctggcccagg gatatgagag aacaagcagc cccaagccta ggttcaagag     1320

ctatgcctac acacaggctg cctatgtgac cacatctgac cccacaagaa gcccatttcc     1380

aagccagcat ctggaagccc ctgaggacaa gagctttggc agcagcctga tggaatctga     1440

agtgaacctg gatagatacc agacagccct ggaagaagtg ctgtcctggc tgctgtctgc     1500

tgaggataca ctgcaggctc agggtgaaat cagcaatgat gtggaagtgg tcaaggacca     1560

gtttcacacc catgagggct acatgatgga cctgacagcc caccagggca gagtgggaaa     1620

tatcctgcag ctgggctcca agctgattgg cacaggcaag ctgtctgagg atgaagagac     1680

agaggtgcaa gagcagatga acctgctgaa cagcagatgg gagtgtctga gagtggccag     1740

catggaaaag cagagcaacc tgcacagagt gctcatggac ctgcagaatc agaaactgaa     1800

agaactgaat gactggctga ccaagacaga agaaaggact aggaagatgg aagaggaacc     1860

tctgggacca gacctggaag atctgaaaag acaggtgcag cagcataagg tgctgcaaga     1920

ggaccttgag caagagcaag tcagagtgaa cagcctgaca cacatggtgg tggttgtgga     1980

tgagtcctct ggggatcatg ccacagctgc tctggaagaa cagctgaagg tgctgggaga     2040

cagatgggcc aacatctgta ggtggacaga ggatagatgg gtgctgctcc aggacattct     2100

gctgaagtgg cagagactga cagaggaaca gtgcctgttt tctgcctggc tctctgagaa     2160

agaggatgct gtcaacaaga tccataccac aggcttcaag gatcagaatg agatgctcag     2220

ctccctgcag aaactggctg tgctgaaggc tgacctggaa aagaaaaagc agtccatggg     2280

caagctctac agcctgaagc aggacctgct gtctaccctg aagaacaagt ctgtgaccca     2340

gaaaactgag gcctggctgg acaactttgc tagatgctgg gacaacctgg tgcagaagct     2400

ggaaaagtct acagcccaga tcagccagca acctgatctt gcccctggcc tgaccacaat     2460

tggagcctct ccaacacaga ctgtgaccct ggttacccag ccagtggtca ccaaagagac     2520

agccatcagc aaactggaaa tgcccagctc tctgatgctg gaagtcccca cactggaaag     2580

gctgcaagaa cttcaagagg ccacagatga gctggacctg aagctgagac aggctgaagt     2640

gatcaaaggc agctggcagc cagttgggga cctgctcatt gatagcctgc aggaccatct     2700

ggaaaaagtg aaagccctga ggggagagat tgcccctctg aaagaaaatg tgtcccatgt     2760

gaatgacctg gccagacagc tgaccacact gggaatccag ctgagcccct acaacctgag     2820

cacccttgag gacctgaaca ccaggtggaa gctcctccag gtggcagtgg aagatagagt     2880

caggcagctg catgaggccc acagagattt tggaccagcc agccagcact ttctgtctac     2940

ctctgtgcaa ggcccctggg agagagctat ctctcctaac aaggtgccct actacatcaa     3000

ccatgagaca cagaccacct gttgggatca ccccaagatg acagagctgt accagagtct     3060

ggcagacctc aacaatgtca gattcagtgc ctacaggact gccatgaagc tcagaaggct     3120

ccagaaagct ctgtgcctgg acctgctttc cctgagtgca gcttgtgatg ccctggacca     3180

gcacaatctg aagcagaatg accagcctat ggacatcctc cagatcatca actgcctcac     3240

caccatctat gataggctgg aacaagagca caacaatctg gtcaatgtgc ccctgtgtgt     3300

ggacatgtgc ctgaattggc tgctgaatgt gtatgacaca ggcagaacag gcaggatcag     3360

agtcctgtcc ttcaagacag gcatcatctc cctgtgcaaa gcccacttgg aggacaagta     3420

cagatacctg ttcaagcaag tggcctccag cacaggcttt tgtgaccaga gaaggctggg     3480

cctgctcctg catgacagca ttcagatccc tagacagctg ggagaagtgg cttcctttgg     3540

aggcagcaat attgagccat cagtcaggtc ctgttttcag tttgccaaca acaagcctga     3600

gattgaggct gccctgttcc tggactggat gagacttgag cctcagagca tggtctggct     3660

gcctgtgctt catagagtgg ctgctgctga gactgccaag caccaggcca agtgcaacat     3720

ctgcaaagag tgccccatca ttggcttcag atacagatcc ctgaagcact tcaactatga     3780

tatctgccag agctgcttct ttagtggcag ggttgccaag ggccacaaaa tgcactaccc     3840

catggtggaa tactgcaccc caacaacctc tggggaagat gttagagact ttgccaaggt     3900

gctgaaaaac aagttcagga ccaagagata ctttgctaag caccccagaa tgggctacct     3960

gcctgtccag acagtgcttg agggtgacaa catggaaacc cctgtgacac tgatcaattt     4020

ctggccagtg gactctgccc ctgcctcaag tccacagctg tcccatgatg acacccacag     4080

cagaattgag cactatgcct ccagactggc agagatggaa aacagcaatg gcagctacct     4140

gaatgatagc atcagcccca atgagagcat tgatgatgag catctgctga tccagcacta     4200

ctgtcagtcc ctgaaccagg actctccact gagccagcct agaagccctg ctcagatcct     4260

gatcagcctt gagtctgagg aaaggggaga gctggaaaga atcctggcag atcttgagga     4320

agagaacaga aacctgcagg cagagtatga caggctcaaa cagcagcatg agcacaaggg     4380

actgagccct ctgccttctc ctcctgaaat gatgcccacc tctccacagt ctccaaggtg     4440

atgactcgag aggcctaata aagagctcag atgcatcgat cagagtgtgt tggttttttg     4500

tgtgccaggg taatgggcta gctgcggccg caggaacccc tagtgatgga gttggccact     4560

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     4620

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca g                         4661


<210>  57
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  57
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720


<210>  58
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  58
cagcaagtgt ccattgaggc cattcaagag gttgag                                 36


<210>  59
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  59
atgctgccca gacctcctaa agtgaccaaa gaggaacact tccagctgca ccaccagatg       60

cactactctc agcagatcac agtgtctctg gcccagggat atgagagaac aagcagcccc      120

aagcctaggt tcaagagcta tgcctacaca caggctgcct atgtgaccac atctgacccc      180

acaagaagcc catttccaag ccagcatctg gaagcccctg aggac                      225


<210>  60
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  60
aagagctttg gcagcagcct gatggaa                                           27


<210>  61
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  61
tctgaagtga acctggatag ataccagaca gccctggaag aagtgctgtc ctggctgctg       60

tctgctgagg atacactgca ggctcagggt gaaatcagca atgatgtgga agtggtcaag      120

gaccagtttc acacccatga gggctacatg atggacctga cagcccacca gggcagagtg      180

ggaaatatcc tgcagctggg ctccaagctg attggcacag gcaagctgtc tgaggatgaa      240

gagacagagg tgcaagagca gatgaacctg ctgaacagca gatgggagtg tctgagagtg      300

gccagcatgg aaaagcagag caacctgcac aga                                   333


<210>  62
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  62
gtgctcatgg acctgcagaa tcagaaactg aaagaactga atgactggct gaccaagaca       60

gaagaaagga ctaggaagat ggaagaggaa cctctgggac cagacctgga agatctgaaa      120

agacaggtgc agcagcataa ggtgctgcaa gaggaccttg agcaagagca agtcagagtg      180

aacagcctga cacacatggt ggtggttgtg gatgagtcct ctggggatca tgccacagct      240

gctctggaag aacagctgaa ggtgctggga gacagatggg ccaacatctg taggtggaca      300

gaggatagat gggtgctgct ccaggac                                          327


<210>  63
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  63
attctg                                                                   6


<210>  64
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  64
ctgaagtggc agagactgac agaggaacag tgcctgtttt ctgcctggct ctctgagaaa       60

gaggatgctg tcaacaagat ccataccaca ggcttcaagg atcagaatga gatgctcagc      120

tccctgcaga aactggctgt gctgaaggct gacctggaaa agaaaaagca gtccatgggc      180

aagctctaca gcctgaagca ggacctgctg tctaccctga agaacaagtc tgtgacccag      240

aaaactgagg cctggctgga caactttgct agatgctggg acaacctggt gcagaagctg      300

gaaaagtcta cagcccagat cagccag                                          327


<210>  65
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  65
caacctgatc ttgcccctgg cctgaccaca attggagcct ctccaacaca gactgtgacc       60

ctggttaccc agccagtggt caccaaagag acagccatca gcaaactgga aatgcccagc      120

tctctgatgc tggaagtccc c                                                141


<210>  66
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  66
acactggaa                                                                9


<210>  67
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  67
aggctgcaag aacttcaaga ggccacagat gagctggacc tgaagctgag acaggctgaa       60

gtgatcaaag gcagctggca gccagttggg gacctgctca ttgatagcct gcaggaccat      120

ctggaaaaag tgaaagccct gaggggagag attgcccctc tgaaagaaaa tgtgtcccat      180

gtgaatgacc tggccagaca gctgaccaca ctgggaatcc agctgagccc ctacaacctg      240

agcacccttg aggacctgaa caccaggtgg aagctcctcc aggtggcagt ggaagataga      300

gtcaggcagc tgcatgag                                                    318


<210>  68
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  68
gcccacagag attttggacc agccagccag cactttctgt ctacctctgt gcaaggcccc       60

tgggagagag ctatctctcc taacaaggtg ccctactaca tcaaccatga gacacagacc      120

acctgttggg atcaccccaa gatgacagag ctgtaccaga gtctggcaga cctcaacaat      180

gtcagattca gtgcctacag gactgccatg aagctc                                216


<210>  69
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  69
agaaggctcc agaaagctct gtgcctggac ctgctttccc tgagtgcagc ttgtgatgcc       60

ctggaccagc acaatctgaa gcagaatgac cagcctatgg acatcctcca gatcatcaac      120

tgcctcacca ccatctatga taggctggaa caagagcaca acaatctggt caatgtgccc      180

ctgtgtgtgg acatgtgcct gaattggctg ctgaatgtgt atgacacagg cagaacaggc      240

aggatcagag tcctgtcctt caagacaggc atcatctccc tgtgcaaagc ccacttggag      300

gacaagtaca gatacctgtt caagcaagtg gcctccagca caggcttttg tgaccagaga      360

aggctgggcc tgctcctgca tgacagcatt cagatcccta gacagctggg agaagtggct      420

tcctttggag gcagcaatat tgagccatca gtcaggtcct gttttcagtt tgccaacaac      480

aagcctgaga ttgaggctgc cctgttcctg gactggatga gacttgagcc tcagagcatg      540

gtctggctgc ctgtgcttca tagagtggct gctgctgaga ctgccaagca ccaggccaag      600

tgcaacatct gcaaagagtg ccccatcatt ggcttcagat acagatccct gaagcacttc      660

aactatgata tctgccagag ctgcttcttt agtggcaggg ttgccaaggg ccacaaaatg      720

cactacccca tggtggaata ctgc                                             744


<210>  70
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  70
accccaacaa cctctgggga agatgttaga gactttgcca aggtgctgaa aaacaagttc       60

aggaccaaga gatactttgc taagcacccc agaatgggct acctgcctgt ccagacagtg      120

cttgagggtg acaacatgga aacccctgtg acactgatca atttctggcc agtggactct      180

gcccctgcct caagtccaca gctgtcccat gatgacaccc acagcagaat tgagcactat      240

gcctccagac tggcagagat ggaaaacagc aatggcagct acctgaatga tagcatcagc      300

cccaatgaga gcattgatga tgagcatctg ctgatccagc actactgtca gtccctgaac      360

caggactctc cactgagcca gcctagaagc cctgctcaga tcctgatcag ccttgagtct      420

gaggaaaggg gagagctgga aagaatcctg gcagatcttg aggaagagaa cagaaacctg      480

caggcagagt atgacaggct caaacagcag catgagcaca agggactgag ccctctgcct      540

tctcctcctg aaatgatgcc cacctctcca cagtctccaa ggtgatga                   588


<210>  71
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  71
gaaacactgg aa                                                           12


<210>  72
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  72
ctggaa                                                                   6


<210>  73
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; viral peptide

<400>  73
cgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg       60

gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta      120

ggggttcct                                                              129


<210>  74
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; viral peptide

<400>  74
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  75
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; chimeric intron

<400>  75
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  76
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; intron

<400>  76
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  77
<211>  738
<212>  PRT
<213>  adeno-associated virus 8

<400>  77

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  78
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  78

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  79
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin protein

<400>  79

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Gln Pro Asp Leu Ala 
            660                 665                 670         


Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu 
        675                 680                 685             


Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu 
    690                 695                 700                 


Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr Leu Glu Arg Leu Gln 
705                 710                 715                 720 


Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala 
                725                 730                 735     


Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp 
            740                 745                 750         


Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile 
        755                 760                 765             


Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln 
    770                 775                 780                 


Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu 
785                 790                 795                 800 


Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 
                805                 810                 815     


Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser 
            820                 825                 830         


Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile 
        835                 840                 845             


Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr 
    850                 855                 860                 


Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp 
865                 870                 875                 880 


Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg 
                885                 890                 895     


Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala 
            900                 905                 910         


Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met 
        915                 920                 925             


Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 
    930                 935                 940                 


Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met 
945                 950                 955                 960 


Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg 
                965                 970                 975     


Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala 
            980                 985                 990         


His Leu Glu Asp Lys Tyr Arg Tyr  Leu Phe Lys Gln Val  Ala Ser Ser 
        995                 1000                 1005             


Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly Leu Leu  Leu His Asp 
    1010                 1015                 1020             


Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu Val Ala  Ser Phe Gly 
    1025                 1030                 1035             


Gly Ser  Asn Ile Glu Pro Ser  Val Arg Ser Cys Phe  Gln Phe Ala 
    1040                 1045                 1050             


Asn Asn  Lys Pro Glu Ile Glu  Ala Ala Leu Phe Leu  Asp Trp Met 
    1055                 1060                 1065             


Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu Pro Val  Leu His Arg 
    1070                 1075                 1080             


Val Ala  Ala Ala Glu Thr Ala  Lys His Gln Ala Lys  Cys Asn Ile 
    1085                 1090                 1095             


Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys 
    1100                 1105                 1110             


His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg 
    1115                 1120                 1125             


Val Ala  Lys Gly His Lys Met  His Tyr Pro Met Val  Glu Tyr Cys 
    1130                 1135                 1140             


Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val 
    1145                 1150                 1155             


Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro 
    1160                 1165                 1170             


Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn 
    1175                 1180                 1185             


Met Glu  Thr Pro Val Thr Leu  Ile Asn Phe Trp Pro  Val Asp Ser 
    1190                 1195                 1200             


Ala Pro  Ala Ser Ser Pro Gln  Leu Ser His Asp Asp  Thr His Ser 
    1205                 1210                 1215             


Arg Ile  Glu His Tyr Ala Ser  Arg Leu Ala Glu Met  Glu Asn Ser 
    1220                 1225                 1230             


Asn Gly  Ser Tyr Leu Asn Asp  Ser Ile Ser Pro Asn  Glu Ser Ile 
    1235                 1240                 1245             


Asp Asp  Glu His Leu Leu Ile  Gln His Tyr Cys Gln  Ser Leu Asn 
    1250                 1255                 1260             


Gln Asp  Ser Pro Leu Ser Gln  Pro Arg Ser Pro Ala  Gln Ile Leu 
    1265                 1270                 1275             


Ile Ser  Leu Glu Ser 
    1280             


<210>  80
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  80
accccaacaa cctctgggga agatgttaga gactttgcca aggtgctgaa aaacaagttc       60

aggaccaaga gatactttgc taagcacccc agaatgggct acctgcctgt ccagacagtg      120

cttgagggtg acaacatgga aacccctgtg acactgatca atttctggcc agtggactct      180

gcccctgcct caagtccaca gctgtcccat gatgacaccc acagcagaat tgagcactat      240

gcctccagac tggcagagat ggaaaacagc aatggcagct acctgaatga tagcatcagc      300

cccaatgaga gcattgatga tgagcatctg ctgatccagc actactgtca gtccctgaac      360

caggactctc cactgagcca gcctagaagc cctgctcaga tcctgatcag ccttgagtct      420

tgatga                                                                 426


<210>  81
<211>  3855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  81
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaagtgt ccattgaggc cattcaagag gttgagatgc tgcccagacc tcctaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcacagtg      840

tctctggccc agggatatga gagaacaagc agccccaagc ctaggttcaa gagctatgcc      900

tacacacagg ctgcctatgt gaccacatct gaccccacaa gaagcccatt tccaagccag      960

catctggaag cccctgagga caagagcttt ggcagcagcc tgatggaatc tgaagtgaac     1020

ctggatagat accagacagc cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat     1080

acactgcagg ctcagggtga aatcagcaat gatgtggaag tggtcaagga ccagtttcac     1140

acccatgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg aaatatcctg     1200

cagctgggct ccaagctgat tggcacaggc aagctgtctg aggatgaaga gacagaggtg     1260

caagagcaga tgaacctgct gaacagcaga tgggagtgtc tgagagtggc cagcatggaa     1320

aagcagagca acctgcacag agtgctcatg gacctgcaga atcagaaact gaaagaactg     1380

aatgactggc tgaccaagac agaagaaagg actaggaaga tggaagagga acctctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcata aggtgctgca agaggacctt     1500

gagcaagagc aagtcagagt gaacagcctg acacacatgg tggtggttgt ggatgagtcc     1560

tctggggatc atgccacagc tgctctggaa gaacagctga aggtgctggg agacagatgg     1620

gccaacatct gtaggtggac agaggataga tgggtgctgc tccaggacat tctgctgaag     1680

tggcagagac tgacagagga acagtgcctg ttttctgcct ggctctctga gaaagaggat     1740

gctgtcaaca agatccatac cacaggcttc aaggatcaga atgagatgct cagctccctg     1800

cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa agcagtccat gggcaagctc     1860

tacagcctga agcaggacct gctgtctacc ctgaagaaca agtctgtgac ccagaaaact     1920

gaggcctggc tggacaactt tgctagatgc tgggacaacc tggtgcagaa gctggaaaag     1980

tctacagccc agatcagcca gcaacctgat cttgcccctg gcctgaccac aattggagcc     2040

tctccaacac agactgtgac cctggttacc cagccagtgg tcaccaaaga gacagccatc     2100

agcaaactgg aaatgcccag ctctctgatg ctggaagtcc ccacactgga aaggctgcaa     2160

gaacttcaag aggccacaga tgagctggac ctgaagctga gacaggctga agtgatcaaa     2220

ggcagctggc agccagttgg ggacctgctc attgatagcc tgcaggacca tctggaaaaa     2280

gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa atgtgtccca tgtgaatgac     2340

ctggccagac agctgaccac actgggaatc cagctgagcc cctacaacct gagcaccctt     2400

gaggacctga acaccaggtg gaagctcctc caggtggcag tggaagatag agtcaggcag     2460

ctgcatgagg cccacagaga ttttggacca gccagccagc actttctgtc tacctctgtg     2520

caaggcccct gggagagagc tatctctcct aacaaggtgc cctactacat caaccatgag     2580

acacagacca cctgttggga tcaccccaag atgacagagc tgtaccagag tctggcagac     2640

ctcaacaatg tcagattcag tgcctacagg actgccatga agctcagaag gctccagaaa     2700

gctctgtgcc tggacctgct ttccctgagt gcagcttgtg atgccctgga ccagcacaat     2760

ctgaagcaga atgaccagcc tatggacatc ctccagatca tcaactgcct caccaccatc     2820

tatgataggc tggaacaaga gcacaacaat ctggtcaatg tgcccctgtg tgtggacatg     2880

tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa caggcaggat cagagtcctg     2940

tccttcaaga caggcatcat ctccctgtgc aaagcccact tggaggacaa gtacagatac     3000

ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc agagaaggct gggcctgctc     3060

ctgcatgaca gcattcagat ccctagacag ctgggagaag tggcttcctt tggaggcagc     3120

aatattgagc catcagtcag gtcctgtttt cagtttgcca acaacaagcc tgagattgag     3180

gctgccctgt tcctggactg gatgagactt gagcctcaga gcatggtctg gctgcctgtg     3240

cttcatagag tggctgctgc tgagactgcc aagcaccagg ccaagtgcaa catctgcaaa     3300

gagtgcccca tcattggctt cagatacaga tccctgaagc acttcaacta tgatatctgc     3360

cagagctgct tctttagtgg cagggttgcc aagggccaca aaatgcacta ccccatggtg     3420

gaatactgca ccccaacaac ctctggggaa gatgttagag actttgccaa ggtgctgaaa     3480

aacaagttca ggaccaagag atactttgct aagcacccca gaatgggcta cctgcctgtc     3540

cagacagtgc ttgagggtga caacatggaa acccctgtga cactgatcaa tttctggcca     3600

gtggactctg cccctgcctc aagtccacag ctgtcccatg atgacaccca cagcagaatt     3660

gagcactatg cctccagact ggcagagatg gaaaacagca atggcagcta cctgaatgat     3720

agcatcagcc ccaatgagag cattgatgat gagcatctgc tgatccagca ctactgtcag     3780

tccctgaacc aggactctcc actgagccag cctagaagcc ctgctcagat cctgatcagc     3840

cttgagtctt gatga                                                      3855


<210>  82
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  82
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaagcgga attcgccacc atgctttggt gggaagaggt ggaagattgc tatgagaggg      540

aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc ccagttcagc aagtttggca      600

agcagcacat tgagaacctg ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc      660

tggaaggcct gacaggccag aagctgccta aagagaaggg cagcacaaga gtgcatgccc      720

tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa caatgtggac ctggtcaata      780

ttggcagcac agacattgtg gatggcaacc acaagctgac cctgggcctg atctggaaca      840

tcatcctgca ctggcaagtg aagaatgtga tgaagaacat catggctggc ctgcagcaga      900

ccaactctga gaagatcctg ctgagctggg tcagacagag caccagaaac taccctcaag      960

tgaatgtgat caacttcacc acctcttgga gtgatggact ggccctgaat gccctgatcc     1020

acagccacag acctgacctg tttgactgga actctgttgt gtgccagcag tctgccacac     1080

agagactgga acatgccttc aacattgcca gataccagct gggaattgag aaactgctgg     1140

accctgagga tgtggacacc acctatcctg acaagaaatc catcctcatg tacatcacca     1200

gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc cattcaagag gttgagatgc     1260

tgcccagacc tcctaaagtg accaaagagg aacacttcca gctgcaccac cagatgcact     1320

actctcagca gatcacagtg tctctggccc agggatatga gagaacaagc agccccaagc     1380

ctaggttcaa gagctatgcc tacacacagg ctgcctatgt gaccacatct gaccccacaa     1440

gaagcccatt tccaagccag catctggaag cccctgagga caagagcttt ggcagcagcc     1500

tgatggaatc tgaagtgaac ctggatagat accagacagc cctggaagaa gtgctgtcct     1560

ggctgctgtc tgctgaggat acactgcagg ctcagggtga aatcagcaat gatgtggaag     1620

tggtcaagga ccagtttcac acccatgagg gctacatgat ggacctgaca gcccaccagg     1680

gcagagtggg aaatatcctg cagctgggct ccaagctgat tggcacaggc aagctgtctg     1740

aggatgaaga gacagaggtg caagagcaga tgaacctgct gaacagcaga tgggagtgtc     1800

tgagagtggc cagcatggaa aagcagagca acctgcacag agtgctcatg gacctgcaga     1860

atcagaaact gaaagaactg aatgactggc tgaccaagac agaagaaagg actaggaaga     1920

tggaagagga acctctggga ccagacctgg aagatctgaa aagacaggtg cagcagcata     1980

aggtgctgca agaggacctt gagcaagagc aagtcagagt gaacagcctg acacacatgg     2040

tggtggttgt ggatgagtcc tctggggatc atgccacagc tgctctggaa gaacagctga     2100

aggtgctggg agacagatgg gccaacatct gtaggtggac agaggataga tgggtgctgc     2160

tccaggacat tctgctgaag tggcagagac tgacagagga acagtgcctg ttttctgcct     2220

ggctctctga gaaagaggat gctgtcaaca agatccatac cacaggcttc aaggatcaga     2280

atgagatgct cagctccctg cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa     2340

agcagtccat gggcaagctc tacagcctga agcaggacct gctgtctacc ctgaagaaca     2400

agtctgtgac ccagaaaact gaggcctggc tggacaactt tgctagatgc tgggacaacc     2460

tggtgcagaa gctggaaaag tctacagccc agatcagcca gcaacctgat cttgcccctg     2520

gcctgaccac aattggagcc tctccaacac agactgtgac cctggttacc cagccagtgg     2580

tcaccaaaga gacagccatc agcaaactgg aaatgcccag ctctctgatg ctggaagtcc     2640

ccacactgga aaggctgcaa gaacttcaag aggccacaga tgagctggac ctgaagctga     2700

gacaggctga agtgatcaaa ggcagctggc agccagttgg ggacctgctc attgatagcc     2760

tgcaggacca tctggaaaaa gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa     2820

atgtgtccca tgtgaatgac ctggccagac agctgaccac actgggaatc cagctgagcc     2880

cctacaacct gagcaccctt gaggacctga acaccaggtg gaagctcctc caggtggcag     2940

tggaagatag agtcaggcag ctgcatgagg cccacagaga ttttggacca gccagccagc     3000

actttctgtc tacctctgtg caaggcccct gggagagagc tatctctcct aacaaggtgc     3060

cctactacat caaccatgag acacagacca cctgttggga tcaccccaag atgacagagc     3120

tgtaccagag tctggcagac ctcaacaatg tcagattcag tgcctacagg actgccatga     3180

agctcagaag gctccagaaa gctctgtgcc tggacctgct ttccctgagt gcagcttgtg     3240

atgccctgga ccagcacaat ctgaagcaga atgaccagcc tatggacatc ctccagatca     3300

tcaactgcct caccaccatc tatgataggc tggaacaaga gcacaacaat ctggtcaatg     3360

tgcccctgtg tgtggacatg tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa     3420

caggcaggat cagagtcctg tccttcaaga caggcatcat ctccctgtgc aaagcccact     3480

tggaggacaa gtacagatac ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc     3540

agagaaggct gggcctgctc ctgcatgaca gcattcagat ccctagacag ctgggagaag     3600

tggcttcctt tggaggcagc aatattgagc catcagtcag gtcctgtttt cagtttgcca     3660

acaacaagcc tgagattgag gctgccctgt tcctggactg gatgagactt gagcctcaga     3720

gcatggtctg gctgcctgtg cttcatagag tggctgctgc tgagactgcc aagcaccagg     3780

ccaagtgcaa catctgcaaa gagtgcccca tcattggctt cagatacaga tccctgaagc     3840

acttcaacta tgatatctgc cagagctgct tctttagtgg cagggttgcc aagggccaca     3900

aaatgcacta ccccatggtg gaatactgca ccccaacaac ctctggggaa gatgttagag     3960

actttgccaa ggtgctgaaa aacaagttca ggaccaagag atactttgct aagcacccca     4020

gaatgggcta cctgcctgtc cagacagtgc ttgagggtga caacatggaa acccctgtga     4080

cactgatcaa tttctggcca gtggactctg cccctgcctc aagtccacag ctgtcccatg     4140

atgacaccca cagcagaatt gagcactatg cctccagact ggcagagatg gaaaacagca     4200

atggcagcta cctgaatgat agcatcagcc ccaatgagag cattgatgat gagcatctgc     4260

tgatccagca ctactgtcag tccctgaacc aggactctcc actgagccag cctagaagcc     4320

ctgctcagat cctgatcagc cttgagtctt gatgagtcga caggcctaat aaagagctca     4380

gatgcatcga tcagagtgtg ttggtttttt gtgtggctag ctgcggccgc aggaacccct     4440

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4500

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     4560


<210>  83
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  83

Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu 
1               5                   10                  15      


Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met 
            20                  25                  30          


Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 
        35                  40                  45              


Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser 
    50                  55                  60                  


Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr 
65                  70                  75                  80  


Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn 
                85                  90                  95      


Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile 
            100                 105                 110         


Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro 
        115                 120                 125             


Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser 
    130                 135                 140 


<210>  84
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; minimal alpha-syntrophin binding site

<400>  84

Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn 
1               5                   10                  15      


Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser 
            20                  25                  30          


Leu Asn Gln 
        35  


<210>  85
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; capsid sequence

<400>  85

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  86
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  86

Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
1               5                   10                  15      


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
            20                  25                  30          


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
        35                  40                  45              


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
    50                  55                  60                  


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
65                  70                  75                  80  


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
                85                  90                  95      


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg 
            100                 105                 110 


<210>  87
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  87

Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
1               5                   10                  15      


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
            20                  25                  30          


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
        35                  40                  45              


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
    50                  55                  60                  


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
65                  70                  75                  80  


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
                85                  90                  95      


Ser Asp Arg Lys Lys Arg Leu Glu Glu 
            100                 105 


<210>  88
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; microdystrophin segment

<400>  88

Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser 
1               5                   10                  15      


Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 
            20                  25                  30          


Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn 
        35                  40                  45              


Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His 
    50                  55                  60                  


Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val 
65                  70                  75                  80  


Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 
                85                  90                  95      


Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 
            100                 105                 110         


Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu 
        115                 120                 125             


Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp 
    130                 135                 140                 


Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 
145                 150                 155                 160 


Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu 
                165                 170                 175     


Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys 
            180                 185                 190         


Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser 
        195                 200                 205             


Asp Arg Lys Lys Arg Leu Glu Glu 
    210                 215     


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  89

Gln Thr Leu Glu 
1               


<210>  90
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  90

Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile 
1               5                   10                  15      


Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln 
            20                  25                  30          


Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr 
        35                  40                  45              


Pro Met Val Glu Tyr Cys 
    50                  


<210>  91
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  91

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Gln Pro Asp Leu Ala 
            660                 665                 670         


Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu 
        675                 680                 685             


Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu 
    690                 695                 700                 


Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr Leu Glu Arg Leu Gln 
705                 710                 715                 720 


Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala 
                725                 730                 735     


Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp 
            740                 745                 750         


Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile 
        755                 760                 765             


Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln 
    770                 775                 780                 


Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu 
785                 790                 795                 800 


Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 
                805                 810                 815     


Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser 
            820                 825                 830         


Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile 
        835                 840                 845             


Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr 
    850                 855                 860                 


Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp 
865                 870                 875                 880 


Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg 
                885                 890                 895     


Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala 
            900                 905                 910         


Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met 
        915                 920                 925             


Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 
    930                 935                 940                 


Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met 
945                 950                 955                 960 


Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg 
                965                 970                 975     


Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala 
            980                 985                 990         


His Leu Glu Asp Lys Tyr Arg Tyr  Leu Phe Lys Gln Val  Ala Ser Ser 
        995                 1000                 1005             


Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly Leu Leu  Leu His Asp 
    1010                 1015                 1020             


Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu Val Ala  Ser Phe Gly 
    1025                 1030                 1035             


Gly Ala  Lys His Gln Ala Lys  Cys Asn Ile Cys Lys  Glu Cys Pro 
    1040                 1045                 1050             


Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys His Phe  Asn Tyr Asp 
    1055                 1060                 1065             


Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg Val Ala  Lys Gly His 
    1070                 1075                 1080             


Lys Met  His Tyr Pro Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser 
    1085                 1090                 1095             


Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe 
    1100                 1105                 1110             


Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu 
    1115                 1120                 1125             


Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn Met Glu  Thr Pro Val 
    1130                 1135                 1140             


Thr Leu  Ile Asn Phe Trp Pro  Val Asp Ser Ala Pro  Ala Ser Ser 
    1145                 1150                 1155             


Pro Gln  Leu Ser His Asp Asp  Thr His Ser Arg Ile  Glu His Tyr 
    1160                 1165                 1170             


Ala Ser  Arg Leu Ala Glu Met  Glu Asn Ser Asn Gly  Ser Tyr Leu 
    1175                 1180                 1185             


Asn Asp  Ser Ile Ser Pro Asn  Glu Ser Ile Asp Asp  Glu His Leu 
    1190                 1195                 1200             


Leu Ile  Gln His Tyr Cys Gln  Ser Leu Asn Gln Asp  Ser Pro Leu 
    1205                 1210                 1215             


Ser Gln  Pro Arg Ser Pro Ala  Gln Ile Leu Ile Ser  Leu Glu Ser 
    1220                 1225                 1230             


Glu Glu  Arg Gly Glu Leu Glu  Arg Ile Leu Ala Asp  Leu Glu Glu 
    1235                 1240                 1245             


Glu Asn  Arg Asn Leu Gln Ala  Glu Tyr Asp Arg Leu  Lys Gln Gln 
    1250                 1255                 1260             


His Glu  His Lys Gly Leu Ser  Pro Leu Pro Ser Pro  Pro Glu Met 
    1265                 1270                 1275             


Met Pro  Thr Ser Pro Gln Ser  Pro Arg 
    1280                 1285         


<210>  92
<211>  1345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  92

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Glu Ile 
545                 550                 555                 560 


Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 
                565                 570                 575     


Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala 
            580                 585                 590         


Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile 
        595                 600                 605             


Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser 
    610                 615                 620                 


Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 
625                 630                 635                 640 


Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 
                645                 650                 655     


Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys 
            660                 665                 670         


Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr 
        675                 680                 685             


Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu 
    690                 695                 700                 


His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly 
705                 710                 715                 720 


Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile 
                725                 730                 735     


Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu 
            740                 745                 750         


Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp 
        755                 760                 765             


Arg Lys Lys Arg Leu Glu Glu Gln Thr Leu Glu Arg Leu Gln Glu Leu 
    770                 775                 780                 


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
785                 790                 795                 800 


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
                805                 810                 815     


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
            820                 825                 830         


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
        835                 840                 845             


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
    850                 855                 860                 


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
865                 870                 875                 880 


Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His 
                885                 890                 895     


Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro 
            900                 905                 910         


Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp 
        915                 920                 925             


Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn 
    930                 935                 940                 


Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu 
945                 950                 955                 960 


Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp 
                965                 970                 975     


Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile 
            980                 985                 990         


Leu Gln Ile Ile Asn Cys Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln 
        995                 1000                 1005             


Glu His  Asn Asn Leu Val Asn  Val Pro Leu Cys Val  Asp Met Cys 
    1010                 1015                 1020             


Leu Asn  Trp Leu Leu Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg 
    1025                 1030                 1035             


Ile Arg  Val Leu Ser Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys 
    1040                 1045                 1050             


Ala His  Leu Glu Asp Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala 
    1055                 1060                 1065             


Ser Ser  Thr Gly Phe Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu 
    1070                 1075                 1080             


His Asp  Ser Ile Gln Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser 
    1085                 1090                 1095             


Phe Gly  Gly Ser Asn Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln 
    1100                 1105                 1110             


Phe Ala  Asn Asn Lys Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp 
    1115                 1120                 1125             


Trp Met  Arg Leu Glu Pro Gln  Ser Met Val Trp Leu  Pro Val Leu 
    1130                 1135                 1140             


His Arg  Val Ala Ala Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys 
    1145                 1150                 1155             


Asn Ile  Cys Lys Glu Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser 
    1160                 1165                 1170             


Leu Lys  His Phe Asn Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser 
    1175                 1180                 1185             


Gly Arg  Val Ala Lys Gly His  Lys Met His Tyr Pro  Met Val Glu 
    1190                 1195                 1200             


Tyr Cys  Thr Pro Thr Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala 
    1205                 1210                 1215             


Lys Val  Leu Lys Asn Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys 
    1220                 1225                 1230             


His Pro  Arg Met Gly Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly 
    1235                 1240                 1245             


Asp Asn  Met Glu Thr Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val 
    1250                 1255                 1260             


Asp Ser  Ala Pro Ala Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr 
    1265                 1270                 1275             


His Ser  Arg Ile Glu His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu 
    1280                 1285                 1290             


Asn Ser  Asn Gly Ser Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu 
    1295                 1300                 1305             


Ser Ile  Asp Asp Glu His Leu  Leu Ile Gln His Tyr  Cys Gln Ser 
    1310                 1315                 1320             


Leu Asn  Gln Asp Ser Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln 
    1325                 1330                 1335             


Ile Leu  Ile Ser Leu Glu Ser  
    1340                 1345 


<210>  93
<211>  1253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  93

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Glu Ile 
545                 550                 555                 560 


Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 
                565                 570                 575     


Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala 
            580                 585                 590         


Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile 
        595                 600                 605             


Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser 
    610                 615                 620                 


Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 
625                 630                 635                 640 


Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 
                645                 650                 655     


Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys 
            660                 665                 670         


Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr 
        675                 680                 685             


Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu 
    690                 695                 700                 


His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly 
705                 710                 715                 720 


Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile 
                725                 730                 735     


Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu 
            740                 745                 750         


Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp 
        755                 760                 765             


Arg Lys Lys Arg Leu Glu Glu Gln Thr Leu Glu Arg Leu Gln Glu Leu 
    770                 775                 780                 


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
785                 790                 795                 800 


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
                805                 810                 815     


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
            820                 825                 830         


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
        835                 840                 845             


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
    850                 855                 860                 


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
865                 870                 875                 880 


Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His 
                885                 890                 895     


Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro 
            900                 905                 910         


Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp 
        915                 920                 925             


Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn 
    930                 935                 940                 


Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu 
945                 950                 955                 960 


Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp 
                965                 970                 975     


Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile 
            980                 985                 990         


Leu Gln Ile Ile Asn Cys Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln 
        995                 1000                 1005             


Glu His  Asn Asn Leu Val Asn  Val Pro Leu Cys Val  Asp Met Cys 
    1010                 1015                 1020             


Leu Asn  Trp Leu Leu Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg 
    1025                 1030                 1035             


Ile Arg  Val Leu Ser Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys 
    1040                 1045                 1050             


Ala His  Leu Glu Asp Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala 
    1055                 1060                 1065             


Ser Ser  Thr Gly Phe Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu 
    1070                 1075                 1080             


His Asp  Ser Ile Gln Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser 
    1085                 1090                 1095             


Phe Gly  Gly Ser Asn Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln 
    1100                 1105                 1110             


Phe Ala  Asn Asn Lys Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp 
    1115                 1120                 1125             


Trp Met  Arg Leu Glu Pro Gln  Ser Met Val Trp Leu  Pro Val Leu 
    1130                 1135                 1140             


His Arg  Val Ala Ala Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys 
    1145                 1150                 1155             


Asn Ile  Cys Lys Glu Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser 
    1160                 1165                 1170             


Leu Lys  His Phe Asn Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser 
    1175                 1180                 1185             


Gly Arg  Val Ala Lys Gly His  Lys Met His Tyr Pro  Met Val Glu 
    1190                 1195                 1200             


Tyr Cys  Thr Pro Thr Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala 
    1205                 1210                 1215             


Lys Val  Leu Lys Asn Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys 
    1220                 1225                 1230             


His Pro  Arg Met Gly Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly 
    1235                 1240                 1245             


Asp Asn  Met Glu Thr 
    1250             


<210>  94
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  94
gaaatttctt atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta       60

ttagaagtgg aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc      120

tttaagcaag aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg      180

attgacatta ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg      240

gtgaagctac aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg      300

tacaaggacc gacaagggcg atttgacaga                                       330


<210>  95
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  95
gagaaatggc ggcgttttca ttatgatata aagatattta atcagtggct aacagaagct       60

gaacagtttc tcagaaagac acaaattcct gagaattggg aacatgctaa atacaaatgg      120

tatcttaagg aactccagga tggcattggg cagcggcaaa ctgttgtcag aacattgaat      180

gcaactgggg aagaaataat tcagcaatcc tcaaaaacag atgccagtat tctacaggaa      240

aaattgggaa gcctgaatct gcggtggcag gaggtctgca aacagctgtc agacagaaaa      300

aagaggctag aa                                                          312


<210>  96
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic ocnstruct; dystrophin segment

<400>  96
gaaatttctt atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta       60

ttagaagtgg aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc      120

tttaagcaag aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg      180

attgacatta ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg      240

gtgaagctac aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg      300

tacaaggacc gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat      360

gatataaaga tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa      420

attcctgaga attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc      480

attgggcagc ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag      540

caatcctcaa aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg      600

tggcaggagg tctgcaaaca gctgtcagac agaaaaaaga ggctagaa                   648


<210>  97
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  97
gagatcagct atgtgcccag cacctacctg acagagatca cccatgtgtc tcaggccctg       60

ctggaagtgg aacagctgct gaatgcccct gacctgtgtg ccaaggactt tgaggacctg      120

ttcaagcaag aggaaagcct gaagaacatc aaggacagcc tgcagcagtc ctctggcaga      180

attgacatca tccacagcaa gaaaacagct gccctgcagt ctgccacacc tgtggaaaga      240

gtgaagctgc aagaggccct gagccagctg gacttccagt gggagaaagt gaacaagatg      300

tacaaggaca ggcagggcag atttgataga                                       330


<210>  98
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  98
gaaaagtgga gaaggttcca ctatgacatc aagatcttca accagtggct gacagaggct       60

gagcagttcc tgagaaagac acagatccct gagaactggg agcatgccaa gtacaagtgg      120

tatctgaaag aactgcagga tggcattggc cagagacaga cagttgtcag aaccctgaat      180

gccacagggg aagagatcat ccagcagagc agcaagacag atgccagcat cctgcaagag      240

aagctgggca gcctgaacct gagatggcaa gaagtgtgca agcagctgtc tgacagaaag      300

aagaggctgg aagaa                                                       315


<210>  99
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  99
gagatcagct atgtgcccag cacctacctg acagagatca cccatgtgtc tcaggccctg       60

ctggaagtgg aacagctgct gaatgcccct gacctgtgtg ccaaggactt tgaggacctg      120

ttcaagcaag aggaaagcct gaagaacatc aaggacagcc tgcagcagtc ctctggcaga      180

attgacatca tccacagcaa gaaaacagct gccctgcagt ctgccacacc tgtggaaaga      240

gtgaagctgc aagaggccct gagccagctg gacttccagt gggagaaagt gaacaagatg      300

tacaaggaca ggcagggcag atttgataga agtgtggaaa agtggagaag gttccactat      360

gacatcaaga tcttcaacca gtggctgaca gaggctgagc agttcctgag aaagacacag      420

atccctgaga actgggagca tgccaagtac aagtggtatc tgaaagaact gcaggatggc      480

attggccaga gacagacagt tgtcagaacc ctgaatgcca caggggaaga gatcatccag      540

cagagcagca agacagatgc cagcatcctg caagagaagc tgggcagcct gaacctgaga      600

tggcaagaag tgtgcaagca gctgtctgac agaaagaaga ggctggaaga a               651


<210>  100
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  100
gccaagcacc aggccaagtg caacatctgc aaagagtgcc ccatcattgg cttcagatac       60

agatccctga agcacttcaa ctatgatatc tgccagagct gcttctttag tggcagggtt      120

gccaagggcc acaaaatgca ctaccccatg gtggaatact gc                         162


<210>  101
<211>  3867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  101
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaagtgt ccattgaggc cattcaagag gttgagatgc tgcccagacc tcctaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcacagtg      840

tctctggccc agggatatga gagaacaagc agccccaagc ctaggttcaa gagctatgcc      900

tacacacagg ctgcctatgt gaccacatct gaccccacaa gaagcccatt tccaagccag      960

catctggaag cccctgagga caagagcttt ggcagcagcc tgatggaatc tgaagtgaac     1020

ctggatagat accagacagc cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat     1080

acactgcagg ctcagggtga aatcagcaat gatgtggaag tggtcaagga ccagtttcac     1140

acccatgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg aaatatcctg     1200

cagctgggct ccaagctgat tggcacaggc aagctgtctg aggatgaaga gacagaggtg     1260

caagagcaga tgaacctgct gaacagcaga tgggagtgtc tgagagtggc cagcatggaa     1320

aagcagagca acctgcacag agtgctcatg gacctgcaga atcagaaact gaaagaactg     1380

aatgactggc tgaccaagac agaagaaagg actaggaaga tggaagagga acctctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcata aggtgctgca agaggacctt     1500

gagcaagagc aagtcagagt gaacagcctg acacacatgg tggtggttgt ggatgagtcc     1560

tctggggatc atgccacagc tgctctggaa gaacagctga aggtgctggg agacagatgg     1620

gccaacatct gtaggtggac agaggataga tgggtgctgc tccaggacat tctgctgaag     1680

tggcagagac tgacagagga acagtgcctg ttttctgcct ggctctctga gaaagaggat     1740

gctgtcaaca agatccatac cacaggcttc aaggatcaga atgagatgct cagctccctg     1800

cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa agcagtccat gggcaagctc     1860

tacagcctga agcaggacct gctgtctacc ctgaagaaca agtctgtgac ccagaaaact     1920

gaggcctggc tggacaactt tgctagatgc tgggacaacc tggtgcagaa gctggaaaag     1980

tctacagccc agatcagcca gcaacctgat cttgcccctg gcctgaccac aattggagcc     2040

tctccaacac agactgtgac cctggttacc cagccagtgg tcaccaaaga gacagccatc     2100

agcaaactgg aaatgcccag ctctctgatg ctggaagtcc ccacactgga aaggctgcaa     2160

gaacttcaag aggccacaga tgagctggac ctgaagctga gacaggctga agtgatcaaa     2220

ggcagctggc agccagttgg ggacctgctc attgatagcc tgcaggacca tctggaaaaa     2280

gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa atgtgtccca tgtgaatgac     2340

ctggccagac agctgaccac actgggaatc cagctgagcc cctacaacct gagcaccctt     2400

gaggacctga acaccaggtg gaagctcctc caggtggcag tggaagatag agtcaggcag     2460

ctgcatgagg cccacagaga ttttggacca gccagccagc actttctgtc tacctctgtg     2520

caaggcccct gggagagagc tatctctcct aacaaggtgc cctactacat caaccatgag     2580

acacagacca cctgttggga tcaccccaag atgacagagc tgtaccagag tctggcagac     2640

ctcaacaatg tcagattcag tgcctacagg actgccatga agctcagaag gctccagaaa     2700

gctctgtgcc tggacctgct ttccctgagt gcagcttgtg atgccctgga ccagcacaat     2760

ctgaagcaga atgaccagcc tatggacatc ctccagatca tcaactgcct caccaccatc     2820

tatgataggc tggaacaaga gcacaacaat ctggtcaatg tgcccctgtg tgtggacatg     2880

tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa caggcaggat cagagtcctg     2940

tccttcaaga caggcatcat ctccctgtgc aaagcccact tggaggacaa gtacagatac     3000

ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc agagaaggct gggcctgctc     3060

ctgcatgaca gcattcagat ccctagacag ctgggagaag tggcttcctt tggaggcgcc     3120

aagcaccagg ccaagtgcaa catctgcaaa gagtgcccca tcattggctt cagatacaga     3180

tccctgaagc acttcaacta tgatatctgc cagagctgct tctttagtgg cagggttgcc     3240

aagggccaca aaatgcacta ccccatggtg gaatactgca ccccaacaac ctctggggaa     3300

gatgttagag actttgccaa ggtgctgaaa aacaagttca ggaccaagag atactttgct     3360

aagcacccca gaatgggcta cctgcctgtc cagacagtgc ttgagggtga caacatggaa     3420

acccctgtga cactgatcaa tttctggcca gtggactctg cccctgcctc aagtccacag     3480

ctgtcccatg atgacaccca cagcagaatt gagcactatg cctccagact ggcagagatg     3540

gaaaacagca atggcagcta cctgaatgat agcatcagcc ccaatgagag cattgatgat     3600

gagcatctgc tgatccagca ctactgtcag tccctgaacc aggactctcc actgagccag     3660

cctagaagcc ctgctcagat cctgatcagc cttgagtctg aggaaagggg agagctggaa     3720

agaatcctgg cagatcttga ggaagagaac agaaacctgc aggcagagta tgacaggctc     3780

aaacagcagc atgagcacaa gggactgagc cctctgcctt ctcctcctga aatgatgccc     3840

acctctccac agtctccaag gtgatga                                         3867


<210>  102
<211>  4041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  102
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaagtgt ccattgaggc cattcaagag gttgagatgc tgcccagacc tcctaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcacagtg      840

tctctggccc agggatatga gagaacaagc agccccaagc ctaggttcaa gagctatgcc      900

tacacacagg ctgcctatgt gaccacatct gaccccacaa gaagcccatt tccaagccag      960

catctggaag cccctgagga caagagcttt ggcagcagcc tgatggaatc tgaagtgaac     1020

ctggatagat accagacagc cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat     1080

acactgcagg ctcagggtga aatcagcaat gatgtggaag tggtcaagga ccagtttcac     1140

acccatgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg aaatatcctg     1200

cagctgggct ccaagctgat tggcacaggc aagctgtctg aggatgaaga gacagaggtg     1260

caagagcaga tgaacctgct gaacagcaga tgggagtgtc tgagagtggc cagcatggaa     1320

aagcagagca acctgcacag agtgctcatg gacctgcaga atcagaaact gaaagaactg     1380

aatgactggc tgaccaagac agaagaaagg actaggaaga tggaagagga acctctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcata aggtgctgca agaggacctt     1500

gagcaagagc aagtcagagt gaacagcctg acacacatgg tggtggttgt ggatgagtcc     1560

tctggggatc atgccacagc tgctctggaa gaacagctga aggtgctggg agacagatgg     1620

gccaacatct gtaggtggac agaggataga tgggtgctgc tccaggacat tctggagatc     1680

agctatgtgc ccagcaccta cctgacagag atcacccatg tgtctcaggc cctgctggaa     1740

gtggaacagc tgctgaatgc ccctgacctg tgtgccaagg actttgagga cctgttcaag     1800

caagaggaaa gcctgaagaa catcaaggac agcctgcagc agtcctctgg cagaattgac     1860

atcatccaca gcaagaaaac agctgccctg cagtctgcca cacctgtgga aagagtgaag     1920

ctgcaagagg ccctgagcca gctggacttc cagtgggaga aagtgaacaa gatgtacaag     1980

gacaggcagg gcagatttga tagaagtgtg gaaaagtgga gaaggttcca ctatgacatc     2040

aagatcttca accagtggct gacagaggct gagcagttcc tgagaaagac acagatccct     2100

gagaactggg agcatgccaa gtacaagtgg tatctgaaag aactgcagga tggcattggc     2160

cagagacaga cagttgtcag aaccctgaat gccacagggg aagagatcat ccagcagagc     2220

agcaagacag atgccagcat cctgcaagag aagctgggca gcctgaacct gagatggcaa     2280

gaagtgtgca agcagctgtc tgacagaaag aagaggctgg aagaacagac actggaaagg     2340

ctgcaagaac ttcaagaggc cacagatgag ctggacctga agctgagaca ggctgaagtg     2400

atcaaaggca gctggcagcc agttggggac ctgctcattg atagcctgca ggaccatctg     2460

gaaaaagtga aagccctgag gggagagatt gcccctctga aagaaaatgt gtcccatgtg     2520

aatgacctgg ccagacagct gaccacactg ggaatccagc tgagccccta caacctgagc     2580

acccttgagg acctgaacac caggtggaag ctcctccagg tggcagtgga agatagagtc     2640

aggcagctgc atgaggccca cagagatttt ggaccagcca gccagcactt tctgtctacc     2700

tctgtgcaag gcccctggga gagagctatc tctcctaaca aggtgcccta ctacatcaac     2760

catgagacac agaccacctg ttgggatcac cccaagatga cagagctgta ccagagtctg     2820

gcagacctca acaatgtcag attcagtgcc tacaggactg ccatgaagct cagaaggctc     2880

cagaaagctc tgtgcctgga cctgctttcc ctgagtgcag cttgtgatgc cctggaccag     2940

cacaatctga agcagaatga ccagcctatg gacatcctcc agatcatcaa ctgcctcacc     3000

accatctatg ataggctgga acaagagcac aacaatctgg tcaatgtgcc cctgtgtgtg     3060

gacatgtgcc tgaattggct gctgaatgtg tatgacacag gcagaacagg caggatcaga     3120

gtcctgtcct tcaagacagg catcatctcc ctgtgcaaag cccacttgga ggacaagtac     3180

agatacctgt tcaagcaagt ggcctccagc acaggctttt gtgaccagag aaggctgggc     3240

ctgctcctgc atgacagcat tcagatccct agacagctgg gagaagtggc ttcctttgga     3300

ggcagcaata ttgagccatc agtcaggtcc tgttttcagt ttgccaacaa caagcctgag     3360

attgaggctg ccctgttcct ggactggatg agacttgagc ctcagagcat ggtctggctg     3420

cctgtgcttc atagagtggc tgctgctgag actgccaagc accaggccaa gtgcaacatc     3480

tgcaaagagt gccccatcat tggcttcaga tacagatccc tgaagcactt caactatgat     3540

atctgccaga gctgcttctt tagtggcagg gttgccaagg gccacaaaat gcactacccc     3600

atggtggaat actgcacccc aacaacctct ggggaagatg ttagagactt tgccaaggtg     3660

ctgaaaaaca agttcaggac caagagatac tttgctaagc accccagaat gggctacctg     3720

cctgtccaga cagtgcttga gggtgacaac atggaaaccc ctgtgacact gatcaatttc     3780

tggccagtgg actctgcccc tgcctcaagt ccacagctgt cccatgatga cacccacagc     3840

agaattgagc actatgcctc cagactggca gagatggaaa acagcaatgg cagctacctg     3900

aatgatagca tcagccccaa tgagagcatt gatgatgagc atctgctgat ccagcactac     3960

tgtcagtccc tgaaccagga ctctccactg agccagccta gaagccctgc tcagatcctg     4020

atcagccttg agtcttgatg a                                               4041


<210>  103
<211>  3765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin

<400>  103
atgctttggt gggaagaggt ggaagattgc tatgagaggg aagatgtgca gaagaaaacc       60

ttcaccaaat gggtcaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc tggaaggcct gacaggccag      180

aagctgccta aagagaaggg cagcacaaga gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caatgtggac ctggtcaata ttggcagcac agacattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaatgtga tgaagaacat catggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tcagacagag caccagaaac taccctcaag tgaatgtgat caacttcacc      480

acctcttgga gtgatggact ggccctgaat gccctgatcc acagccacag acctgacctg      540

tttgactgga actctgttgt gtgccagcag tctgccacac agagactgga acatgccttc      600

aacattgcca gataccagct gggaattgag aaactgctgg accctgagga tgtggacacc      660

acctatcctg acaagaaatc catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaagtgt ccattgaggc cattcaagag gttgagatgc tgcccagacc tcctaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcacagtg      840

tctctggccc agggatatga gagaacaagc agccccaagc ctaggttcaa gagctatgcc      900

tacacacagg ctgcctatgt gaccacatct gaccccacaa gaagcccatt tccaagccag      960

catctggaag cccctgagga caagagcttt ggcagcagcc tgatggaatc tgaagtgaac     1020

ctggatagat accagacagc cctggaagaa gtgctgtcct ggctgctgtc tgctgaggat     1080

acactgcagg ctcagggtga aatcagcaat gatgtggaag tggtcaagga ccagtttcac     1140

acccatgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg aaatatcctg     1200

cagctgggct ccaagctgat tggcacaggc aagctgtctg aggatgaaga gacagaggtg     1260

caagagcaga tgaacctgct gaacagcaga tgggagtgtc tgagagtggc cagcatggaa     1320

aagcagagca acctgcacag agtgctcatg gacctgcaga atcagaaact gaaagaactg     1380

aatgactggc tgaccaagac agaagaaagg actaggaaga tggaagagga acctctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcata aggtgctgca agaggacctt     1500

gagcaagagc aagtcagagt gaacagcctg acacacatgg tggtggttgt ggatgagtcc     1560

tctggggatc atgccacagc tgctctggaa gaacagctga aggtgctggg agacagatgg     1620

gccaacatct gtaggtggac agaggataga tgggtgctgc tccaggacat tctggagatc     1680

agctatgtgc ccagcaccta cctgacagag atcacccatg tgtctcaggc cctgctggaa     1740

gtggaacagc tgctgaatgc ccctgacctg tgtgccaagg actttgagga cctgttcaag     1800

caagaggaaa gcctgaagaa catcaaggac agcctgcagc agtcctctgg cagaattgac     1860

atcatccaca gcaagaaaac agctgccctg cagtctgcca cacctgtgga aagagtgaag     1920

ctgcaagagg ccctgagcca gctggacttc cagtgggaga aagtgaacaa gatgtacaag     1980

gacaggcagg gcagatttga tagaagtgtg gaaaagtgga gaaggttcca ctatgacatc     2040

aagatcttca accagtggct gacagaggct gagcagttcc tgagaaagac acagatccct     2100

gagaactggg agcatgccaa gtacaagtgg tatctgaaag aactgcagga tggcattggc     2160

cagagacaga cagttgtcag aaccctgaat gccacagggg aagagatcat ccagcagagc     2220

agcaagacag atgccagcat cctgcaagag aagctgggca gcctgaacct gagatggcaa     2280

gaagtgtgca agcagctgtc tgacagaaag aagaggctgg aagaacagac actggaaagg     2340

ctgcaagaac ttcaagaggc cacagatgag ctggacctga agctgagaca ggctgaagtg     2400

atcaaaggca gctggcagcc agttggggac ctgctcattg atagcctgca ggaccatctg     2460

gaaaaagtga aagccctgag gggagagatt gcccctctga aagaaaatgt gtcccatgtg     2520

aatgacctgg ccagacagct gaccacactg ggaatccagc tgagccccta caacctgagc     2580

acccttgagg acctgaacac caggtggaag ctcctccagg tggcagtgga agatagagtc     2640

aggcagctgc atgaggccca cagagatttt ggaccagcca gccagcactt tctgtctacc     2700

tctgtgcaag gcccctggga gagagctatc tctcctaaca aggtgcccta ctacatcaac     2760

catgagacac agaccacctg ttgggatcac cccaagatga cagagctgta ccagagtctg     2820

gcagacctca acaatgtcag attcagtgcc tacaggactg ccatgaagct cagaaggctc     2880

cagaaagctc tgtgcctgga cctgctttcc ctgagtgcag cttgtgatgc cctggaccag     2940

cacaatctga agcagaatga ccagcctatg gacatcctcc agatcatcaa ctgcctcacc     3000

accatctatg ataggctgga acaagagcac aacaatctgg tcaatgtgcc cctgtgtgtg     3060

gacatgtgcc tgaattggct gctgaatgtg tatgacacag gcagaacagg caggatcaga     3120

gtcctgtcct tcaagacagg catcatctcc ctgtgcaaag cccacttgga ggacaagtac     3180

agatacctgt tcaagcaagt ggcctccagc acaggctttt gtgaccagag aaggctgggc     3240

ctgctcctgc atgacagcat tcagatccct agacagctgg gagaagtggc ttcctttgga     3300

ggcagcaata ttgagccatc agtcaggtcc tgttttcagt ttgccaacaa caagcctgag     3360

attgaggctg ccctgttcct ggactggatg agacttgagc ctcagagcat ggtctggctg     3420

cctgtgcttc atagagtggc tgctgctgag actgccaagc accaggccaa gtgcaacatc     3480

tgcaaagagt gccccatcat tggcttcaga tacagatccc tgaagcactt caactatgat     3540

atctgccaga gctgcttctt tagtggcagg gttgccaagg gccacaaaat gcactacccc     3600

atggtggaat actgcacccc aacaacctct ggggaagatg ttagagactt tgccaaggtg     3660

ctgaaaaaca agttcaggac caagagatac tttgctaagc accccagaat gggctacctg     3720

cctgtccaga cagtgcttga gggtgacaac atggaaacct gatga                     3765


<210>  104
<211>  4584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  104
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaagcgga attcgccacc atgctttggt gggaagaggt ggaagattgc tatgagaggg      540

aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc ccagttcagc aagtttggca      600

agcagcacat tgagaacctg ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc      660

tggaaggcct gacaggccag aagctgccta aagagaaggg cagcacaaga gtgcatgccc      720

tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa caatgtggac ctggtcaata      780

ttggcagcac agacattgtg gatggcaacc acaagctgac cctgggcctg atctggaaca      840

tcatcctgca ctggcaagtg aagaatgtga tgaagaacat catggctggc ctgcagcaga      900

ccaactctga gaagatcctg ctgagctggg tcagacagag caccagaaac taccctcaag      960

tgaatgtgat caacttcacc acctcttgga gtgatggact ggccctgaat gccctgatcc     1020

acagccacag acctgacctg tttgactgga actctgttgt gtgccagcag tctgccacac     1080

agagactgga acatgccttc aacattgcca gataccagct gggaattgag aaactgctgg     1140

accctgagga tgtggacacc acctatcctg acaagaaatc catcctcatg tacatcacca     1200

gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc cattcaagag gttgagatgc     1260

tgcccagacc tcctaaagtg accaaagagg aacacttcca gctgcaccac cagatgcact     1320

actctcagca gatcacagtg tctctggccc agggatatga gagaacaagc agccccaagc     1380

ctaggttcaa gagctatgcc tacacacagg ctgcctatgt gaccacatct gaccccacaa     1440

gaagcccatt tccaagccag catctggaag cccctgagga caagagcttt ggcagcagcc     1500

tgatggaatc tgaagtgaac ctggatagat accagacagc cctggaagaa gtgctgtcct     1560

ggctgctgtc tgctgaggat acactgcagg ctcagggtga aatcagcaat gatgtggaag     1620

tggtcaagga ccagtttcac acccatgagg gctacatgat ggacctgaca gcccaccagg     1680

gcagagtggg aaatatcctg cagctgggct ccaagctgat tggcacaggc aagctgtctg     1740

aggatgaaga gacagaggtg caagagcaga tgaacctgct gaacagcaga tgggagtgtc     1800

tgagagtggc cagcatggaa aagcagagca acctgcacag agtgctcatg gacctgcaga     1860

atcagaaact gaaagaactg aatgactggc tgaccaagac agaagaaagg actaggaaga     1920

tggaagagga acctctggga ccagacctgg aagatctgaa aagacaggtg cagcagcata     1980

aggtgctgca agaggacctt gagcaagagc aagtcagagt gaacagcctg acacacatgg     2040

tggtggttgt ggatgagtcc tctggggatc atgccacagc tgctctggaa gaacagctga     2100

aggtgctggg agacagatgg gccaacatct gtaggtggac agaggataga tgggtgctgc     2160

tccaggacat tctgctgaag tggcagagac tgacagagga acagtgcctg ttttctgcct     2220

ggctctctga gaaagaggat gctgtcaaca agatccatac cacaggcttc aaggatcaga     2280

atgagatgct cagctccctg cagaaactgg ctgtgctgaa ggctgacctg gaaaagaaaa     2340

agcagtccat gggcaagctc tacagcctga agcaggacct gctgtctacc ctgaagaaca     2400

agtctgtgac ccagaaaact gaggcctggc tggacaactt tgctagatgc tgggacaacc     2460

tggtgcagaa gctggaaaag tctacagccc agatcagcca gcaacctgat cttgcccctg     2520

gcctgaccac aattggagcc tctccaacac agactgtgac cctggttacc cagccagtgg     2580

tcaccaaaga gacagccatc agcaaactgg aaatgcccag ctctctgatg ctggaagtcc     2640

ccacactgga aaggctgcaa gaacttcaag aggccacaga tgagctggac ctgaagctga     2700

gacaggctga agtgatcaaa ggcagctggc agccagttgg ggacctgctc attgatagcc     2760

tgcaggacca tctggaaaaa gtgaaagccc tgaggggaga gattgcccct ctgaaagaaa     2820

atgtgtccca tgtgaatgac ctggccagac agctgaccac actgggaatc cagctgagcc     2880

cctacaacct gagcaccctt gaggacctga acaccaggtg gaagctcctc caggtggcag     2940

tggaagatag agtcaggcag ctgcatgagg cccacagaga ttttggacca gccagccagc     3000

actttctgtc tacctctgtg caaggcccct gggagagagc tatctctcct aacaaggtgc     3060

cctactacat caaccatgag acacagacca cctgttggga tcaccccaag atgacagagc     3120

tgtaccagag tctggcagac ctcaacaatg tcagattcag tgcctacagg actgccatga     3180

agctcagaag gctccagaaa gctctgtgcc tggacctgct ttccctgagt gcagcttgtg     3240

atgccctgga ccagcacaat ctgaagcaga atgaccagcc tatggacatc ctccagatca     3300

tcaactgcct caccaccatc tatgataggc tggaacaaga gcacaacaat ctggtcaatg     3360

tgcccctgtg tgtggacatg tgcctgaatt ggctgctgaa tgtgtatgac acaggcagaa     3420

caggcaggat cagagtcctg tccttcaaga caggcatcat ctccctgtgc aaagcccact     3480

tggaggacaa gtacagatac ctgttcaagc aagtggcctc cagcacaggc ttttgtgacc     3540

agagaaggct gggcctgctc ctgcatgaca gcattcagat ccctagacag ctgggagaag     3600

tggcttcctt tggaggcgcc aagcaccagg ccaagtgcaa catctgcaaa gagtgcccca     3660

tcattggctt cagatacaga tccctgaagc acttcaacta tgatatctgc cagagctgct     3720

tctttagtgg cagggttgcc aagggccaca aaatgcacta ccccatggtg gaatactgca     3780

ccccaacaac ctctggggaa gatgttagag actttgccaa ggtgctgaaa aacaagttca     3840

ggaccaagag atactttgct aagcacccca gaatgggcta cctgcctgtc cagacagtgc     3900

ttgagggtga caacatggaa acccctgtga cactgatcaa tttctggcca gtggactctg     3960

cccctgcctc aagtccacag ctgtcccatg atgacaccca cagcagaatt gagcactatg     4020

cctccagact ggcagagatg gaaaacagca atggcagcta cctgaatgat agcatcagcc     4080

ccaatgagag cattgatgat gagcatctgc tgatccagca ctactgtcag tccctgaacc     4140

aggactctcc actgagccag cctagaagcc ctgctcagat cctgatcagc cttgagtctg     4200

aggaaagggg agagctggaa agaatcctgg cagatcttga ggaagagaac agaaacctgc     4260

aggcagagta tgacaggctc aaacagcagc atgagcacaa gggactgagc cctctgcctt     4320

ctcctcctga aatgatgccc acctctccac agtctccaag gtgatgactc gagaggccta     4380

ataaagagct cagatgcatc gatcagagtg tgttggtttt ttgtgtgcca gggtaatggg     4440

ctagctgcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4500

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4560

ctcagtgagc gagcgagcgc gcag                                            4584


<210>  105
<211>  4746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin cassette

<400>  105
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaagcgga attcgccacc atgctttggt gggaagaggt ggaagattgc tatgagaggg      540

aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc ccagttcagc aagtttggca      600

agcagcacat tgagaacctg ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc      660

tggaaggcct gacaggccag aagctgccta aagagaaggg cagcacaaga gtgcatgccc      720

tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa caatgtggac ctggtcaata      780

ttggcagcac agacattgtg gatggcaacc acaagctgac cctgggcctg atctggaaca      840

tcatcctgca ctggcaagtg aagaatgtga tgaagaacat catggctggc ctgcagcaga      900

ccaactctga gaagatcctg ctgagctggg tcagacagag caccagaaac taccctcaag      960

tgaatgtgat caacttcacc acctcttgga gtgatggact ggccctgaat gccctgatcc     1020

acagccacag acctgacctg tttgactgga actctgttgt gtgccagcag tctgccacac     1080

agagactgga acatgccttc aacattgcca gataccagct gggaattgag aaactgctgg     1140

accctgagga tgtggacacc acctatcctg acaagaaatc catcctcatg tacatcacca     1200

gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc cattcaagag gttgagatgc     1260

tgcccagacc tcctaaagtg accaaagagg aacacttcca gctgcaccac cagatgcact     1320

actctcagca gatcacagtg tctctggccc agggatatga gagaacaagc agccccaagc     1380

ctaggttcaa gagctatgcc tacacacagg ctgcctatgt gaccacatct gaccccacaa     1440

gaagcccatt tccaagccag catctggaag cccctgagga caagagcttt ggcagcagcc     1500

tgatggaatc tgaagtgaac ctggatagat accagacagc cctggaagaa gtgctgtcct     1560

ggctgctgtc tgctgaggat acactgcagg ctcagggtga aatcagcaat gatgtggaag     1620

tggtcaagga ccagtttcac acccatgagg gctacatgat ggacctgaca gcccaccagg     1680

gcagagtggg aaatatcctg cagctgggct ccaagctgat tggcacaggc aagctgtctg     1740

aggatgaaga gacagaggtg caagagcaga tgaacctgct gaacagcaga tgggagtgtc     1800

tgagagtggc cagcatggaa aagcagagca acctgcacag agtgctcatg gacctgcaga     1860

atcagaaact gaaagaactg aatgactggc tgaccaagac agaagaaagg actaggaaga     1920

tggaagagga acctctggga ccagacctgg aagatctgaa aagacaggtg cagcagcata     1980

aggtgctgca agaggacctt gagcaagagc aagtcagagt gaacagcctg acacacatgg     2040

tggtggttgt ggatgagtcc tctggggatc atgccacagc tgctctggaa gaacagctga     2100

aggtgctggg agacagatgg gccaacatct gtaggtggac agaggataga tgggtgctgc     2160

tccaggacat tctggagatc agctatgtgc ccagcaccta cctgacagag atcacccatg     2220

tgtctcaggc cctgctggaa gtggaacagc tgctgaatgc ccctgacctg tgtgccaagg     2280

actttgagga cctgttcaag caagaggaaa gcctgaagaa catcaaggac agcctgcagc     2340

agtcctctgg cagaattgac atcatccaca gcaagaaaac agctgccctg cagtctgcca     2400

cacctgtgga aagagtgaag ctgcaagagg ccctgagcca gctggacttc cagtgggaga     2460

aagtgaacaa gatgtacaag gacaggcagg gcagatttga tagaagtgtg gaaaagtgga     2520

gaaggttcca ctatgacatc aagatcttca accagtggct gacagaggct gagcagttcc     2580

tgagaaagac acagatccct gagaactggg agcatgccaa gtacaagtgg tatctgaaag     2640

aactgcagga tggcattggc cagagacaga cagttgtcag aaccctgaat gccacagggg     2700

aagagatcat ccagcagagc agcaagacag atgccagcat cctgcaagag aagctgggca     2760

gcctgaacct gagatggcaa gaagtgtgca agcagctgtc tgacagaaag aagaggctgg     2820

aagaacagac actggaaagg ctgcaagaac ttcaagaggc cacagatgag ctggacctga     2880

agctgagaca ggctgaagtg atcaaaggca gctggcagcc agttggggac ctgctcattg     2940

atagcctgca ggaccatctg gaaaaagtga aagccctgag gggagagatt gcccctctga     3000

aagaaaatgt gtcccatgtg aatgacctgg ccagacagct gaccacactg ggaatccagc     3060

tgagccccta caacctgagc acccttgagg acctgaacac caggtggaag ctcctccagg     3120

tggcagtgga agatagagtc aggcagctgc atgaggccca cagagatttt ggaccagcca     3180

gccagcactt tctgtctacc tctgtgcaag gcccctggga gagagctatc tctcctaaca     3240

aggtgcccta ctacatcaac catgagacac agaccacctg ttgggatcac cccaagatga     3300

cagagctgta ccagagtctg gcagacctca acaatgtcag attcagtgcc tacaggactg     3360

ccatgaagct cagaaggctc cagaaagctc tgtgcctgga cctgctttcc ctgagtgcag     3420

cttgtgatgc cctggaccag cacaatctga agcagaatga ccagcctatg gacatcctcc     3480

agatcatcaa ctgcctcacc accatctatg ataggctgga acaagagcac aacaatctgg     3540

tcaatgtgcc cctgtgtgtg gacatgtgcc tgaattggct gctgaatgtg tatgacacag     3600

gcagaacagg caggatcaga gtcctgtcct tcaagacagg catcatctcc ctgtgcaaag     3660

cccacttgga ggacaagtac agatacctgt tcaagcaagt ggcctccagc acaggctttt     3720

gtgaccagag aaggctgggc ctgctcctgc atgacagcat tcagatccct agacagctgg     3780

gagaagtggc ttcctttgga ggcagcaata ttgagccatc agtcaggtcc tgttttcagt     3840

ttgccaacaa caagcctgag attgaggctg ccctgttcct ggactggatg agacttgagc     3900

ctcagagcat ggtctggctg cctgtgcttc atagagtggc tgctgctgag actgccaagc     3960

accaggccaa gtgcaacatc tgcaaagagt gccccatcat tggcttcaga tacagatccc     4020

tgaagcactt caactatgat atctgccaga gctgcttctt tagtggcagg gttgccaagg     4080

gccacaaaat gcactacccc atggtggaat actgcacccc aacaacctct ggggaagatg     4140

ttagagactt tgccaaggtg ctgaaaaaca agttcaggac caagagatac tttgctaagc     4200

accccagaat gggctacctg cctgtccaga cagtgcttga gggtgacaac atggaaaccc     4260

ctgtgacact gatcaatttc tggccagtgg actctgcccc tgcctcaagt ccacagctgt     4320

cccatgatga cacccacagc agaattgagc actatgcctc cagactggca gagatggaaa     4380

acagcaatgg cagctacctg aatgatagca tcagccccaa tgagagcatt gatgatgagc     4440

atctgctgat ccagcactac tgtcagtccc tgaaccagga ctctccactg agccagccta     4500

gaagccctgc tcagatcctg atcagccttg agtcttgatg agtcgacagg cctaataaag     4560

agctcagatg catcgatcag agtgtgttgg ttttttgtgt ggctagctgc ggccgcagga     4620

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     4680

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     4740

gcgcag                                                                4746


<210>  106
<211>  4470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystropin cassette

<400>  106
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct catatgcagg gtaatgggga tcctctagag gccgtccgcc ctcggcacca      180

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      240

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      300

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      360

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      420

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      480

gccaagcgga attcgccacc atgctttggt gggaagaggt ggaagattgc tatgagaggg      540

aagatgtgca gaagaaaacc ttcaccaaat gggtcaatgc ccagttcagc aagtttggca      600

agcagcacat tgagaacctg ttcagtgacc tgcaggatgg cagaaggctg ctggatctgc      660

tggaaggcct gacaggccag aagctgccta aagagaaggg cagcacaaga gtgcatgccc      720

tgaacaatgt gaacaaggcc ctgagagtgc tgcagaacaa caatgtggac ctggtcaata      780

ttggcagcac agacattgtg gatggcaacc acaagctgac cctgggcctg atctggaaca      840

tcatcctgca ctggcaagtg aagaatgtga tgaagaacat catggctggc ctgcagcaga      900

ccaactctga gaagatcctg ctgagctggg tcagacagag caccagaaac taccctcaag      960

tgaatgtgat caacttcacc acctcttgga gtgatggact ggccctgaat gccctgatcc     1020

acagccacag acctgacctg tttgactgga actctgttgt gtgccagcag tctgccacac     1080

agagactgga acatgccttc aacattgcca gataccagct gggaattgag aaactgctgg     1140

accctgagga tgtggacacc acctatcctg acaagaaatc catcctcatg tacatcacca     1200

gcctgttcca ggtgctgccc cagcaagtgt ccattgaggc cattcaagag gttgagatgc     1260

tgcccagacc tcctaaagtg accaaagagg aacacttcca gctgcaccac cagatgcact     1320

actctcagca gatcacagtg tctctggccc agggatatga gagaacaagc agccccaagc     1380

ctaggttcaa gagctatgcc tacacacagg ctgcctatgt gaccacatct gaccccacaa     1440

gaagcccatt tccaagccag catctggaag cccctgagga caagagcttt ggcagcagcc     1500

tgatggaatc tgaagtgaac ctggatagat accagacagc cctggaagaa gtgctgtcct     1560

ggctgctgtc tgctgaggat acactgcagg ctcagggtga aatcagcaat gatgtggaag     1620

tggtcaagga ccagtttcac acccatgagg gctacatgat ggacctgaca gcccaccagg     1680

gcagagtggg aaatatcctg cagctgggct ccaagctgat tggcacaggc aagctgtctg     1740

aggatgaaga gacagaggtg caagagcaga tgaacctgct gaacagcaga tgggagtgtc     1800

tgagagtggc cagcatggaa aagcagagca acctgcacag agtgctcatg gacctgcaga     1860

atcagaaact gaaagaactg aatgactggc tgaccaagac agaagaaagg actaggaaga     1920

tggaagagga acctctggga ccagacctgg aagatctgaa aagacaggtg cagcagcata     1980

aggtgctgca agaggacctt gagcaagagc aagtcagagt gaacagcctg acacacatgg     2040

tggtggttgt ggatgagtcc tctggggatc atgccacagc tgctctggaa gaacagctga     2100

aggtgctggg agacagatgg gccaacatct gtaggtggac agaggataga tgggtgctgc     2160

tccaggacat tctggagatc agctatgtgc ccagcaccta cctgacagag atcacccatg     2220

tgtctcaggc cctgctggaa gtggaacagc tgctgaatgc ccctgacctg tgtgccaagg     2280

actttgagga cctgttcaag caagaggaaa gcctgaagaa catcaaggac agcctgcagc     2340

agtcctctgg cagaattgac atcatccaca gcaagaaaac agctgccctg cagtctgcca     2400

cacctgtgga aagagtgaag ctgcaagagg ccctgagcca gctggacttc cagtgggaga     2460

aagtgaacaa gatgtacaag gacaggcagg gcagatttga tagaagtgtg gaaaagtgga     2520

gaaggttcca ctatgacatc aagatcttca accagtggct gacagaggct gagcagttcc     2580

tgagaaagac acagatccct gagaactggg agcatgccaa gtacaagtgg tatctgaaag     2640

aactgcagga tggcattggc cagagacaga cagttgtcag aaccctgaat gccacagggg     2700

aagagatcat ccagcagagc agcaagacag atgccagcat cctgcaagag aagctgggca     2760

gcctgaacct gagatggcaa gaagtgtgca agcagctgtc tgacagaaag aagaggctgg     2820

aagaacagac actggaaagg ctgcaagaac ttcaagaggc cacagatgag ctggacctga     2880

agctgagaca ggctgaagtg atcaaaggca gctggcagcc agttggggac ctgctcattg     2940

atagcctgca ggaccatctg gaaaaagtga aagccctgag gggagagatt gcccctctga     3000

aagaaaatgt gtcccatgtg aatgacctgg ccagacagct gaccacactg ggaatccagc     3060

tgagccccta caacctgagc acccttgagg acctgaacac caggtggaag ctcctccagg     3120

tggcagtgga agatagagtc aggcagctgc atgaggccca cagagatttt ggaccagcca     3180

gccagcactt tctgtctacc tctgtgcaag gcccctggga gagagctatc tctcctaaca     3240

aggtgcccta ctacatcaac catgagacac agaccacctg ttgggatcac cccaagatga     3300

cagagctgta ccagagtctg gcagacctca acaatgtcag attcagtgcc tacaggactg     3360

ccatgaagct cagaaggctc cagaaagctc tgtgcctgga cctgctttcc ctgagtgcag     3420

cttgtgatgc cctggaccag cacaatctga agcagaatga ccagcctatg gacatcctcc     3480

agatcatcaa ctgcctcacc accatctatg ataggctgga acaagagcac aacaatctgg     3540

tcaatgtgcc cctgtgtgtg gacatgtgcc tgaattggct gctgaatgtg tatgacacag     3600

gcagaacagg caggatcaga gtcctgtcct tcaagacagg catcatctcc ctgtgcaaag     3660

cccacttgga ggacaagtac agatacctgt tcaagcaagt ggcctccagc acaggctttt     3720

gtgaccagag aaggctgggc ctgctcctgc atgacagcat tcagatccct agacagctgg     3780

gagaagtggc ttcctttgga ggcagcaata ttgagccatc agtcaggtcc tgttttcagt     3840

ttgccaacaa caagcctgag attgaggctg ccctgttcct ggactggatg agacttgagc     3900

ctcagagcat ggtctggctg cctgtgcttc atagagtggc tgctgctgag actgccaagc     3960

accaggccaa gtgcaacatc tgcaaagagt gccccatcat tggcttcaga tacagatccc     4020

tgaagcactt caactatgat atctgccaga gctgcttctt tagtggcagg gttgccaagg     4080

gccacaaaat gcactacccc atggtggaat actgcacccc aacaacctct ggggaagatg     4140

ttagagactt tgccaaggtg ctgaaaaaca agttcaggac caagagatac tttgctaagc     4200

accccagaat gggctacctg cctgtccaga cagtgcttga gggtgacaac atggaaacct     4260

gatgagtcga caggcctaat aaagagctca gatgcatcga tcagagtgtg ttggtttttt     4320

gtgtggctag ctgcggccgc aggaacccct agtgatggag ttggccactc cctctctgcg     4380

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4440

ggcggcctca gtgagcgagc gagcgcgcag                                      4470


<210>  107
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  107
tctgtt                                                                   6


<210>  108
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  108
gaaacccttg aa                                                           12


<210>  109
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; dystrophin segment

<400>  109
gccaagcatc aggccaaatg taacatctgc aaagagtgtc caatcattgg attcaggtac       60

aggagtctaa agcactttaa ttatgacatc tgccaaagct gctttttttc tggtcgagtt      120

gcaaaaggcc ataaaatgca ctatcccatg gtggaatatt gc                         162


<210>  110
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  110

Ser Val 
1       


<210>  111
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  111
gagacactgg aa                                                           12


<210>  112
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; capsid sequence

<400>  112

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  113
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; capsid sequence

<400>  113

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Gly Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Ser Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  114
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; capsid sequence

<400>  114

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gly Ile Asn Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn 
                85                  90                  95      


His Ala Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe 
            100                 105                 110         


Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu 
        115                 120                 125             


Glu Pro Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys 
    130                 135                 140                 


Lys Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly 
145                 150                 155                 160 


Ile Gly Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly 
                165                 170                 175     


Gln Thr Gly Asp Thr Glu Ser Val Pro Asp Pro Gly Ile Asn Pro Ile 
            180                 185                 190         


Gly Glu Pro Pro Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala 
        195                 200                 205             


Ser Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly 
    210                 215                 220                 


Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly 
225                 230                 235                 240 


Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr 
                245                 250                 255     


Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser 
            260                 265                 270         


Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
        275                 280                 285             


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
    290                 295                 300                 


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
305                 310                 315                 320 


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys 
                325                 330                 335     


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
            340                 345                 350         


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu 
        355                 360                 365             


Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu 
    370                 375                 380                 


Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
385                 390                 395                 400 


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln 
                405                 410                 415     


Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His 
            420                 425                 430         


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
        435                 440                 445             


Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr 
    450                 455                 460                 


Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg 
465                 470                 475                 480 


Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr 
                485                 490                 495     


Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser 
            500                 505                 510         


Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met 
        515                 520                 525             


Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser 
    530                 535                 540                 


Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp 
545                 550                 555                 560 


Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val 
                565                 570                 575     


Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln 
            580                 585                 590         


Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly 
        595                 600                 605             


Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala 
    610                 615                 620                 


Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly 
625                 630                 635                 640 


Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr 
                645                 650                 655     


Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn 
            660                 665                 670         


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu 
        675                 680                 685             


Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
    690                 695                 700                 


Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn 
705                 710                 715                 720 


Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu 
                725                 730                 735     


Thr Arg Asn Leu 
            740 


<210>  115
<211>  865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  115
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tcccctgcat gcgaagatct tcgaacaagg ctgtggggga ctgagggcag      480

gctgtaacag gcttgggggc cagggcttat acgtgcctgg gactcccaaa gtattactgt      540

tccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca cttagtttag      600

gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg ctgggcaagc      660

tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag ctcatctgct      720

ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct      780

atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca gcacagacag      840

acactcagga gccagccagc gtcga                                            865


<210>  116
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  116
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaag                     1725


<210>  117
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  117
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210>  118
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  118
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  119
<211>  240
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; desmin sequence

<400>  119
ctgcagacat gcttgctgcc tgccctggcg tgccctggcg aggcttgccg tcacaggacc       60

cccgctggct gactcagggg cgcaggctct tgcgggggag ctggcctccc gcccccacgg      120

ccacgggccc tttcctggca ggacagcggg atcttgcagc tgtcagggga ggggatgacg      180

ggggactgat gtcaggaggg gatacaaata gtgccgaaca aggaccggat tagatctacc      240


<210>  120
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; MHCK7 sequence

<400>  120
aagcttgcat gtctaagcta gacccttcag attaaaaata actgaggtaa gggcctgggt       60

aggggaggtg gtgtgagacg ctcctgtctc tcctctatct gcccatcggc cctttgggga      120

ggaggaatgt gcccaaggac taaaaaaagg ccatggagcc agaggggcga gggcaacaga      180

cctttcatgg gcaaaccttg gggccctgct gtctagcatg ccccactacg ggtctaggct      240

gcccatgtaa ggaggcaagg cctggggaca cccgagatgc ctggttataa ttaacccaga      300

catgtggctg cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt      360

ggatcccctg catgcgaaga tcttcgaaca aggctgtggg ggactgaggg caggctgtaa      420

caggcttggg ggccagggct tatacgtgcc tgggactccc aaagtattac tgttccatgt      480

tcccggcgaa gggccagctg tcccccgcca gctagactca gcacttagtt taggaaccag      540

tgagcaagtc agcccttggg gcagcccata caaggccatg gggctgggca agctgcacgc      600

ctgggtccgg ggtgggcacg gtgcccgggc aacgagctga aagctcatct gctctcaggg      660

gcccctccct ggggacagcc cctcctggct agtcacaccc tgtaggctcc tctatataac      720

ccaggggcac aggggctgcc ctcattctac caccacctcc acagcacaga cagacactca      780

ggagcagcca gc                                                          792


<210>  121
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; truncated MCK

<400>  121
ccactacggg tctaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aaccccaaca cctgctgccc cccccccccc aacacctgct gcctgagcct      120

gagcggttac cccaccccgg tgcctgggtc ttaggctctg tacaccatgg aggagaagct      180

cgctctaaaa ataaccctgt ccctggtgga tccactacgg gtctatgctg cccatgtaag      240

gaggcaaggc ctggggacac ccgagatgcc tggttataat taaccccaac acctgctgcc      300

cccccccccc caacacctgc tgcctgagcc tgagcggtta ccccaccccg gtgcctgggt      360

cttaggctct gtacaccatg gaggagaagc tcgctctaaa aataaccctg tccctggtgg      420

accactacgg gtctaggctg cccatgtaag gaggcaaggc ctggggacac ccgagatgcc      480

tggttataat taaccccaac acctgctgcc cccccccccc aacacctgct gcctgagcct      540

gagcggttac cccaccccgg tgcctgggtc ttaggctctg tacaccatgg aggagaagct      600

cgctctaaaa ataaccctgt ccctggtcct ccctggggac agcccctcct ggctagtcac      660

accctgtagg ctcctctata taacccaggg gcacaggggc tgcccccggg tcac            714


<210>  122
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  122
acagatacct gttcaagcaa gtggc                                             25


<210>  123
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  123
tcaatctcag gcttggc                                                      17


<210>  124
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; primer

<400>  124
caatattgag ccatcagtc                                                    19


<210>  125
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  125
agtgtg                                                                   6


<210>  126
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  126
cagacactgg aa                                                           12


<210>  127
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; capsid sequence

<400>  127

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


