                         SEQUENCE LISTING

<110>  Technische Universitaet Dortmund
 
<120>  METHOD FOR DETERMINING 5-METHYLCYTOSINE CONFIGURATIONS IN DNA

<130>  P80280

<150>  EP19220082.2
<151>  2019-12-30

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Ala Leu Gly Pro Gly Trp Lys Arg Arg Glu Val Phe Arg Lys Ser 
1               5                   10                  15      


Gly Ala Thr Cys Gly Arg Ser Asp Thr Tyr Tyr Gln Ser Pro Thr Gly 
            20                  25                  30          


Asp Arg Ile Arg Ser Lys Val Glu Leu Thr Arg Tyr Leu 
        35                  40                  45  


<210>  2
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Val Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  3
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Ala Leu Pro Gln Gly Trp Glu Arg Glu Glu Val Pro Arg Arg Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly His Arg Asp Val Phe Tyr Tyr Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  4
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Ser Val Pro Cys Gly Trp Glu Arg Val Val Lys Gln Arg Leu Phe 
1               5                   10                  15      


Gly Lys Thr Ala Gly Arg Phe Asp Val Tyr Phe Ile Ser Pro Gln Gly 
            20                  25                  30          


Leu Lys Phe Arg Ser Lys Ser Ser Leu Ala Asn Tyr Leu 
        35                  40                  45  


<210>  5
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  5

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  6
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  6

Pro Ala Leu Gly Pro Gly Trp Lys Arg Arg Glu Ser Phe Arg Lys Ser 
1               5                   10                  15      


Gly Ala Ser Phe Gly Arg Ser Asp Ile Tyr Tyr Gln Ser Pro Thr Gly 
            20                  25                  30          


Glu Lys Ile Arg Ser Lys Val Glu Leu Thr Arg Tyr Leu 
        35                  40                  45  


<210>  7
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  7

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Val Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  8
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  8

Pro Ala Leu Pro Gln Gly Trp Glu Arg Glu Glu Val Pro Arg Arg Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly His Arg Asp Val Phe Tyr Tyr Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  9
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  9

Lys Pro Val Pro Cys Gly Trp Glu Arg Val Val Lys Gln Arg Leu Ser 
1               5                   10                  15      


Gly Lys Thr Ala Gly Lys Phe Asp Val Tyr Phe Ile Ser Pro Gln Gly 
            20                  25                  30          


Leu Lys Phe Arg Ser Lys Arg Ser Leu Ala Asn Tyr Leu 
        35                  40                  45  


<210>  10
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  10

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  11
<211>  45
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Pro Ala Leu Gly Pro Gly Trp Lys Arg Arg Glu Ala Phe Arg Lys Ser 
1               5                   10                  15      


Gly Ala Ser Cys Gly Arg Ser Asp Ile Tyr Tyr Arg Ser Pro Thr Gly 
            20                  25                  30          


Glu Lys Ile Arg Ser Lys Ile Glu Leu Thr Arg Tyr Leu 
        35                  40                  45  


<210>  12
<211>  45
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Val Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  13
<211>  45
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Pro Ala Leu Pro Gln Gly Trp Glu Arg Glu Glu Val Pro Arg Arg Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly His Arg Asp Val Phe Tyr Tyr Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  14
<211>  45
<212>  PRT
<213>  Pan troglodytes

<400>  14

Lys Ser Val Pro Cys Gly Trp Glu Arg Val Val Lys Gln Arg Leu Phe 
1               5                   10                  15      


Gly Lys Thr Ala Gly Arg Phe Asp Val Tyr Phe Ile Ser Pro Gln Gly 
            20                  25                  30          


Leu Lys Phe Arg Ser Lys Ser Ser Leu Ala Asn Tyr Leu 
        35                  40                  45  


<210>  15
<211>  45
<212>  PRT
<213>  Pan troglodytes

<400>  15

Pro Ala Leu Gly Pro Gly Trp Lys Arg Arg Glu Val Phe Arg Lys Ser 
1               5                   10                  15      


Gly Ala Thr Cys Gly Arg Ser Asp Thr Tyr Tyr Gln Ser Pro Thr Gly 
            20                  25                  30          


Asp Arg Ile Arg Ser Lys Val Glu Leu Thr Arg Tyr Leu 
        35                  40                  45  


<210>  16
<211>  45
<212>  PRT
<213>  Pan troglodytes

<400>  16

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  17
<211>  45
<212>  PRT
<213>  Pan troglodytes

<400>  17

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  18
<211>  45
<212>  PRT
<213>  Danio rerio

<400>  18

Pro Ser Leu Pro Gln Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Phe Asp Val Tyr Leu Ile Asn Pro Glu Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Met Ala Tyr Phe 
        35                  40                  45  


<210>  19
<211>  45
<212>  PRT
<213>  Danio rerio

<400>  19

Ser Ala Leu Pro Asn Gly Trp Lys Met Glu Glu Val Thr Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Thr Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Val Arg Tyr Leu 
        35                  40                  45  


<210>  20
<211>  45
<212>  PRT
<213>  Takifugu rubripes

<400>  20

Thr Ala Leu Pro Lys Gly Trp Lys Met Glu Glu Val Thr Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  21
<211>  45
<212>  PRT
<213>  Xenopus laevis

<400>  21

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Phe Asp Val Tyr Leu Ile Asn Pro Asn Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  22
<211>  45
<212>  PRT
<213>  Xenopus laevis

<400>  22

Ser Ala Leu Pro Gln Gly Trp Lys Lys Glu Glu Val Thr Arg Arg Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Tyr Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  23
<211>  45
<212>  PRT
<213>  Xenopus laevis

<400>  23

Pro Ala Leu Pro Ala Gly Trp Lys Lys Glu Glu Val Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Tyr Ser Pro Asn Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  24
<211>  45
<212>  PRT
<213>  Xenopus laevis

<400>  24

Pro Leu Leu Gly Pro Gly Trp Lys Arg Arg Asn Val Val Arg Lys Ser 
1               5                   10                  15      


Gly Ala Thr Cys Gly His Ser Asp Thr Tyr Tyr Arg Ser Pro Ala Gly 
            20                  25                  30          


Lys Lys Ile Arg Ser Arg Ile Glu Leu Ala Lys Tyr Leu 
        35                  40                  45  


<210>  25
<211>  45
<212>  PRT
<213>  Xenopus laevis

<400>  25

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile His Pro Asn Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  26
<211>  45
<212>  PRT
<213>  Gallus gallus

<400>  26

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Val Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  27
<211>  45
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  27

Pro Gly Leu Pro Ala Gly Trp Lys Arg Glu Glu Val Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Thr Asp Val Tyr Tyr Tyr Ser Pro Cys Gly 
            20                  25                  30          


Lys Lys Leu Arg Ser Lys Pro Gln Leu Ala Arg Phe Ile 
        35                  40                  45  


<210>  28
<211>  46
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  28

Trp Pro Leu Ala Asn Gly Trp Arg Arg Gln Thr Ile Ile Arg Gln Leu 
1               5                   10                  15      


Gly Pro Gly Asp Arg Ile Lys Gly Asp Val Ile Tyr Tyr Ala Pro Cys 
            20                  25                  30          


Gly Lys Lys Leu Arg Thr Tyr Pro Glu Val Val Arg Tyr Ile 
        35                  40                  45      


<210>  29
<211>  45
<212>  PRT
<213>  Anopheles gambiae

<400>  29

Ala Ala Leu Pro Lys Gly Trp Gln Arg Glu Glu Val Leu Arg Lys Thr 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Val Asp Val Tyr Tyr Tyr Ser Pro Thr Gly 
            20                  25                  30          


Lys Lys Ile Glu Ser Lys Pro Gln Leu Ala Arg Ala Leu 
        35                  40                  45  


<210>  30
<211>  45
<212>  PRT
<213>  Caenorhabditis elegans

<400>  30

Leu Pro Leu Gln Leu Gly Trp Arg Arg Gln Thr Cys Val Arg Ser Ile 
1               5                   10                  15      


Ala Ser Ala Gly Val Lys Gly Asp Val Ser Tyr Phe Ala Pro Cys Gly 
            20                  25                  30          


Lys Lys Leu Ser Thr Tyr Ser Glu Val Val Arg Tyr Leu 
        35                  40                  45  


<210>  31
<211>  42
<212>  PRT
<213>  Arabidopsis thaliana

<400>  31

Pro Lys Thr Pro Lys Gly Phe Lys Arg Ser Leu Val Leu Arg Lys Asp 
1               5                   10                  15      


Tyr Ser Lys Met Asp Thr Tyr Tyr Phe Thr Pro Thr Gly Lys Lys Leu 
            20                  25                  30          


Arg Ser Arg Asn Glu Ile Ala Ala Phe Val 
        35                  40          


<210>  32
<211>  42
<212>  PRT
<213>  Arabidopsis thaliana

<400>  32

Pro Arg Thr Pro Arg Gly Phe Lys Arg Ser Leu Ile Leu Arg Lys Asp 
1               5                   10                  15      


Tyr Ser Lys Met Asp Ala Tyr Tyr Ile Thr Pro Thr Gly Lys Lys Leu 
            20                  25                  30          


Lys Ser Arg Asn Glu Ile Ala Ala Phe Ile 
        35                  40          


<210>  33
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Pro Leu Gln His Gly Trp Arg Arg Glu Val Arg Ile Lys Lys Gly 
1               5                   10                  15      


Ser His Arg Trp Gln Gly Glu Thr Trp Tyr Tyr Gly Pro Cys Gly Lys 
            20                  25                  30          


Arg Met Lys Gln Phe Pro Glu Val Ile Lys Tyr Leu 
        35                  40                  


<210>  34
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  34

Ile Pro Leu Glu Tyr Gly Trp Gln Arg Glu Thr Arg Ile Arg Asn Phe 
1               5                   10                  15      


Gly Gly Arg Leu Gln Gly Glu Val Ala Tyr Tyr Ala Pro Cys Gly Lys 
            20                  25                  30          


Lys Leu Arg Gln Tyr Pro Glu Val Ile Lys Tyr Leu 
        35                  40                  


<210>  35
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Pro Leu Gln His Gly Trp Arg Arg Glu Val Arg Ile Lys Lys Gly 
1               5                   10                  15      


Ser His Arg Trp Gln Gly Glu Thr Trp Tyr Tyr Gly Pro Cys Gly Lys 
            20                  25                  30          


Arg Met Lys Gln Phe Pro Glu Val Ile Lys Tyr Leu 
        35                  40                  


<210>  36
<211>  44
<212>  PRT
<213>  Gallus gallus

<400>  36

Phe Pro Leu Gln His Gly Trp Arg Arg Glu Val Arg Ile Lys Arg Gly 
1               5                   10                  15      


Asn His Arg Trp Gln Gly Glu Thr Trp Tyr Tyr Gly Pro Cys Gly Lys 
            20                  25                  30          


Arg Met Lys Gln Phe Pro Glu Val Ile Lys Tyr Leu 
        35                  40                  


<210>  37
<211>  44
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Leu Pro Leu Gln His Gly Trp Arg Arg Glu Val Arg Ile Lys Lys Gly 
1               5                   10                  15      


Ser His Arg Trp Gln Gly Glu Thr Trp Tyr Tyr Gly Pro Cys Gly Lys 
            20                  25                  30          


Arg Met Lys Gln Phe Pro Glu Val Ile Lys Tyr Leu 
        35                  40                  


<210>  38
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  38

Val Pro Leu Leu Tyr Asp Phe Arg Arg Met Thr Ala Arg Arg Arg Val 
1               5                   10                  15      


Asn Arg Lys Met Gly Phe His Val Ile Tyr Lys Thr Pro Cys Gly Leu 
            20                  25                  30          


Cys Leu Arg Thr Met Gln Glu Ile Glu Arg Tyr Leu 
        35                  40                  


<210>  39
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  39

Leu Pro Ile Lys Cys His Phe Gln Arg Arg His Ala Lys Thr Asn Ser 
1               5                   10                  15      


His Ser Ser Ala Leu His Val Ser Tyr Lys Thr Pro Cys Gly Arg Ser 
            20                  25                  30          


Leu Arg Asn Val Glu Glu Val Phe Arg Tyr Leu 
        35                  40              


<210>  40
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  40

Val Pro Leu Leu Tyr Asp Phe Arg Arg Met Thr Ala Arg Arg Arg Val 
1               5                   10                  15      


Asn Arg Lys Met Gly Phe His Val Ile Tyr Lys Thr Pro Cys Gly Leu 
            20                  25                  30          


Cys Leu Arg Thr Met Gln Glu Ile Glu Arg Tyr Leu 
        35                  40                  


<210>  41
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Pro Ile Arg Cys His Phe Gln Arg Arg His Ala Lys Thr Asn Ser 
1               5                   10                  15      


His Ser Ser Ala Leu His Val Asn Tyr Lys Thr Pro Cys Gly Arg Asn 
            20                  25                  30          


Leu Arg Asn Met Glu Glu Val Phe His Tyr Leu 
        35                  40              


<210>  42
<211>  44
<212>  PRT
<213>  Takifugu rubripes

<400>  42

Thr Pro Leu Leu Tyr Asp Phe Arg Arg Met Thr Gly Arg Arg Lys Val 
1               5                   10                  15      


Asn Arg Lys Met Ser Phe His Val Ile Tyr Lys Ala Pro Cys Gly Leu 
            20                  25                  30          


Cys Leu Arg Asn Met Ser Glu Ile Gln His Tyr Leu 
        35                  40                  


<210>  43
<211>  44
<212>  PRT
<213>  Xenopus laevis

<400>  43

Val Pro Leu Leu Tyr Asp Phe Arg Arg Met Thr Ala Arg Arg Arg Val 
1               5                   10                  15      


Asn Arg Lys Met Gly Phe His Val Ile Tyr Lys Ser Pro Cys Gly Leu 
            20                  25                  30          


Ser Leu Arg Thr Met Pro Glu Ile Glu Arg Tyr Leu 
        35                  40                  


<210>  44
<211>  44
<212>  PRT
<213>  Gallus gallus

<400>  44

Ile Pro Leu Leu Tyr Asp Phe Arg Arg Met Thr Ala Arg Arg Arg Val 
1               5                   10                  15      


Asn Arg Lys Met Gly Phe His Val Ile Tyr Lys Thr Pro Cys Gly Leu 
            20                  25                  30          


Cys Leu Arg Ser Met Ala Glu Ile Glu Arg Tyr Leu 
        35                  40                  


<210>  45
<211>  44
<212>  PRT
<213>  Rattus norvegicus

<400>  45

Val Pro Leu Leu Tyr Asp Phe Arg Arg Met Thr Ala Arg Arg Arg Val 
1               5                   10                  15      


Asn Arg Lys Met Gly Phe His Val Ile Tyr Lys Thr Pro Cys Gly Leu 
            20                  25                  30          


Cys Leu Arg Thr Met Gln Glu Ile Glu Arg Tyr Leu 
        35                  40                  


<210>  46
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (F105)

<400>  46

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Thr Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Thr Thr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Lys Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  47
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F105-1

<400>  47

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Thr Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Thr Gln Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Lys Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  48
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (F106)

<400>  48

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Thr Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Ala Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Asn Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  49
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F106-1

<400>  49

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Thr Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Cys Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Asn Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  50
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F106-2

<400>  50

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Thr Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Ala Met Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Asn Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  51
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F260

<400>  51

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Asp Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Cys Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Asn Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  52
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (F271)

<400>  52

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Cys Ser Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Gln Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  53
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (F272)

<400>  53

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Ala Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Cys Phe Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Arg Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  54
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F272-1

<400>  54

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Ala Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Leu Met Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Arg Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  55
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (F273)

<400>  55

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Leu Thr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Arg Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  56
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (F274)

<400>  56

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Val Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Leu Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Arg Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  57
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:2 (F275)

<400>  57

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Arg Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr Phe Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Val Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  58
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F246

<400>  58

Pro Ala Leu Pro Gln Gly Trp Glu Arg Glu Glu Leu Pro Arg Arg Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly His Arg Asp Tyr Phe Phe Tyr Ser Pro Ser Gly 
            20                  25                  30          


Lys Lys Phe Arg Phe Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  59
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F245-B14

<400>  59

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Leu Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Ala Asp Tyr Phe Ser Pro Asp Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  60
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F245-B19

<400>  60

Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu Pro Ile Arg Lys Ser 
1               5                   10                  15      


Gly Leu Ser Ala Gly Lys Ser Asp Pro Val Tyr Phe Ser Pro Ala Gly 
            20                  25                  30          


Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu 
        35                  40                  45  


<210>  61
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F246-C1

<400>  61

Glu Arg Lys Arg Trp Glu Cys Pro Ala Leu Pro Gln Gly Trp Glu Arg 
1               5                   10                  15      


Glu Glu Leu Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp Tyr 
            20                  25                  30          


Phe Phe Tyr Ser Pro Ser Gly Lys Lys Phe Arg Phe Lys Pro Gln Leu 
        35                  40                  45              


Ala Arg Tyr Leu Gly Gly Ser Ile Asp Leu Ser Thr Phe Asp Phe Arg 
    50                  55                  60                  


Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg Val 
65                  70                  75                  80  


<210>  62
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F246-A10

<400>  62

Glu Arg Lys Arg Trp Met Cys Pro Ala Leu Pro Gln Gly Trp Glu Arg 
1               5                   10                  15      


Glu Glu Leu Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp Tyr 
            20                  25                  30          


Phe Phe Tyr Ser Pro Ser Gly Lys Lys Phe Arg Phe Lys Pro Gln Leu 
        35                  40                  45              


Ala Arg Tyr Leu Gly Gly Ser Met Asp Leu Ser Thr Phe Asp Phe Arg 
    50                  55                  60                  


Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg Val 
65                  70                  75                  80  


<210>  63
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F245-B23-B3

<400>  63

Ser Gly Lys Arg Met Gly Arg Pro Ala Leu Pro Pro Gly Trp Lys Lys 
1               5                   10                  15      


Glu Glu Leu Ile Arg Lys Ser Gly Leu Ser Ala Gly Lys Ser Asp Ser 
            20                  25                  30          


Gln Tyr Phe Ser Pro Ser Gly Glu Lys Phe Arg Ser Lys Pro Gln Leu 
        35                  40                  45              


Ala Arg Tyr Leu Gly Asn Thr Val Asp Leu Ser Ser Ser Asp Phe Arg 
    50                  55                  60                  


Thr Gly Lys Met Gln Pro Ser Lys Leu Gln Lys Asn Lys Gln Arg Leu 
65                  70                  75                  80  


<210>  64
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F248-D13-A2

<400>  64

Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr His Pro Glu Gly Trp Thr 
1               5                   10                  15      


Arg Lys Leu Ala Gln Arg Lys Ser Gly Arg Cys Ala Gly Lys Tyr Asp 
            20                  25                  30          


Cys Met Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Asn Lys Val Glu 
        35                  40                  45              


Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn 
    50                  55                  60                  


Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu 
65                  70                  75                  80  


Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala 
                85                  90          


<210>  65
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F106-F22

<400>  65

Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Pro Pro Glu Gly Trp Thr 
1               5                   10                  15      


Arg Lys Leu Thr Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp 
            20                  25                  30          


Ala Tyr Leu Ile Asn Pro His Gly Lys Ala Phe Arg Asn Lys Val Glu 
        35                  40                  45              


Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn 
    50                  55                  60                  


Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Gly 
65                  70                  75                  80  


Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala 
                85                  90          


<210>  66
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F106-C23

<400>  66

Tyr Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr 
1               5                   10                  15      


Arg Lys Leu Thr Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp 
            20                  25                  30          


Ala Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Asn Lys Val Glu 
        35                  40                  45              


Leu Ile Ala Tyr Leu Gly Lys Val Gly Asp Thr Ser Leu Asp Pro Asn 
    50                  55                  60                  


Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu 
65                  70                  75                  80  


Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala 
                85                  90          


<210>  67
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant F106-1-B9

<400>  67

Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr 
1               5                   10                  15      


Arg Lys Leu Thr Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp 
            20                  25                  30          


Cys Tyr Leu Ile Leu Pro Gln Gly Lys Ala Leu Arg Asn Lys Val Glu 
        35                  40                  45              


Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn 
    50                  55                  60                  


Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu 
65                  70                  75                  80  


Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala 
                85                  90          


<210>  68
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  hMBD2[146-225]

<400>  68

Ser Gly Lys Arg Met Asp Cys Pro Ala Leu Pro Pro Gly Trp Lys Lys 
1               5                   10                  15      


Glu Glu Val Ile Arg Lys Ser Gly Leu Ser Ala Gly Lys Ser Asp Val 
            20                  25                  30          


Tyr Tyr Phe Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln Leu 
        35                  40                  45              


Ala Arg Tyr Leu Gly Asn Thr Val Asp Leu Ser Ser Phe Asp Phe Arg 
    50                  55                  60                  


Thr Gly Lys Met Met Pro Ser Lys Leu Gln Lys Asn Lys Gln Arg Leu 
65                  70                  75                  80  


<210>  69
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  hMeCp2[90-181]

<400>  69

Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr 
1               5                   10                  15      


Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp 
            20                  25                  30          


Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu 
        35                  40                  45              


Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn 
    50                  55                  60                  


Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu 
65                  70                  75                  80  


Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala 
                85                  90          


<210>  70
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  hMBD1[2-81]

<400>  70

Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp Lys Arg 
1               5                   10                  15      


Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser Asp Thr 
            20                  25                  30          


Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val Glu Leu 
        35                  40                  45              


Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp Phe Lys 
    50                  55                  60                  


Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val Ala Val 
65                  70                  75                  80  


<210>  71
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  hMBD3[2-81]

<400>  71

Glu Arg Lys Arg Trp Glu Cys Pro Ala Leu Pro Gln Gly Trp Glu Arg 
1               5                   10                  15      


Glu Glu Val Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp Val 
            20                  25                  30          


Phe Tyr Tyr Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln Leu 
        35                  40                  45              


Ala Arg Tyr Leu Gly Gly Ser Met Asp Leu Ser Thr Phe Asp Phe Arg 
    50                  55                  60                  


Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg Val 
65                  70                  75                  80  


<210>  72
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  hMBD4[76-167]

<400>  72

Ala Thr Ala Gly Thr Glu Cys Arg Lys Ser Val Pro Cys Gly Trp Glu 
1               5                   10                  15      


Arg Val Val Lys Gln Arg Leu Phe Gly Lys Thr Ala Gly Arg Phe Asp 
            20                  25                  30          


Val Tyr Phe Ile Ser Pro Gln Gly Leu Lys Phe Arg Ser Lys Ser Ser 
        35                  40                  45              


Leu Ala Asn Tyr Leu His Lys Asn Gly Glu Thr Ser Leu Lys Pro Glu 
    50                  55                  60                  


Asp Phe Asp Phe Thr Val Leu Ser Lys Arg Gly Ile Lys Ser Arg Tyr 
65                  70                  75                  80  


Lys Asp Cys Ser Met Ala Ala Leu Thr Ser His Leu 
                85                  90          


<210>  73
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (L124F)

<400>  73

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Phe Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  74
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (R133C)

<400>  74

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Cys Ser Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  75
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  MBD variant of SEQ ID NO:5 (S134C)

<400>  75

Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser 
1               5                   10                  15      


Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly 
            20                  25                  30          


Lys Ala Phe Arg Cys Lys Val Glu Leu Ile Ala Tyr Phe 
        35                  40                  45  


<210>  76
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Variant of hMeCp2[90-181] (T158M)

<400>  76

Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr 
1               5                   10                  15      


Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp 
            20                  25                  30          


Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu 
        35                  40                  45              


Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn 
    50                  55                  60                  


Asp Phe Asp Phe Met Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu 
65                  70                  75                  80  


Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala 
                85                  90          


