                         SEQUENCE LISTING

<110>  TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
 
<120>  CONUS-BASED TOXIN PEPTIDES, NUCLEIC ACIDS ENCODING SAME AND USES 
       THEREOF IN MODULATING NMDA RECEPTORS

<130>  TECH/020 PCT

<150>  62/957,240
<151>  2020-01-05

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Conus purpurascens


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<400>  1

Gly Glu Xaa Xaa His Ser Lys Tyr Gln Xaa Cys Leu Arg Xaa Ile Arg 
1               5                   10                  15      


Val Asn Lys Val Gln Gln Xaa Cys 
            20                  


<210>  2
<211>  17
<212>  PRT
<213>  Conus geographus


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)

<400>  2

Gly Glu Xaa Xaa Leu Gln Xaa Asn Gln Xaa Leu Ile Arg Xaa Lys Ser 
1               5                   10                  15      


Asn 
    


<210>  3
<211>  19
<212>  PRT
<213>  Conus Parius


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  X = GAMMA-CARBOXYLGLUTAMYL (GLA)

<400>  3

Gly Glu Pro Xaa Val Ala Lys Trp Ala Xaa Gly Leu Arg Xaa Lys Ala 
1               5                   10                  15      


Ala Ser Asn 
            


<210>  4
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Glu Glu Glu His Ser Lys Tyr Gln Glu Cys Leu Arg Glu Ile Arg 
1               5                   10                  15      


Val Asn Lys Val Gln Gln Glu Cys 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Ala Ala Ala His Ser Lys Tyr Gln Ala Cys Leu Arg Ala Ile Arg 
1               5                   10                  15      


Val Asn Lys Val Gln Gln Ala Cys 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gly Asp Asp Asp His Ser Lys Tyr Gln Asp Cys Leu Arg Asp Ile Arg 
1               5                   10                  15      


Val Asn Lys Val Gln Gln Asp Cys 
            20                  


<210>  7
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Gly Gly Gly His Ser Lys Tyr Gln Gly Cys Leu Arg Gly Ile Arg 
1               5                   10                  15      


Val Asn Lys Val Gln Gln Gly Cys 
            20                  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gly Glu Glu Glu Leu Gln Glu Asn Gln Glu Leu Ile Arg Glu Lys Ser 
1               5                   10                  15      


Asn 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Glu Glu Glu Leu Gln Ala Asn Gln Glu Leu Ile Arg Glu Lys Ser 
1               5                   10                  15      


Asn 
    


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Glu Glu Glu Leu Gln Glu Asn Gln Glu Leu Ile Arg 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Glu Glu Glu Leu Gln Ala Asn Gln Glu Leu Ile Arg 
1               5                   10              


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Ala Ala Ala Leu Gln Ala Asn Gln Ala Leu Ile Arg Ala Lys Ser 
1               5                   10                  15      


Asn 
    


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Glu Pro Glu Val Ala Lys Trp Ala Glu Gly Leu Arg Glu Lys Ala 
1               5                   10                  15      


Ala Ser Asn 
            


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu 
1               5                   10                  15  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Asn Glu Leu Gln Gln Glu Ser Ile Leu Glu Arg Lys Glu Asn Glu Gly 
1               5                   10                  15      


Glu 
    


<210>  16
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
aacgagctgc agcaggagag catcctggag aggaaggaga acgagggcga g                51


<210>  17
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
ggcgaagaag agcacagcaa ataccaggag tgcctgaggg agatcagagt caacaaggtg       60

cagcaagaat gt                                                           72


<210>  18
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ggcgccgccg cccacagcaa gtaccaggcc tgcctgaggg ccatcagggt gaacaaggtg       60

cagcaggcct gc                                                           72


<210>  19
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ggcgacgacg accacagcaa gtaccaggac tgcctgaggg acatcagggt gaacaaggtg       60

cagcaggact gc                                                           72


<210>  20
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
ggcggcggcg gccacagcaa gtaccagggc tgcctgaggg gcatcagggt gaacaaggtg       60

cagcagggct gc                                                           72


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ggcgaggagg agctgcagga gaaccaggag ctgatcaggg agaagagcaa c                51


<210>  22
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ggcgaggagg agctgcaggc caaccaggag ctgatcaggg agaagagcaa c                51


<210>  23
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ggcgaggagg agctgcagga gaaccaggag ctgatcagg                              39


<210>  24
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ggcgaggagg agctgcaggc caaccaggag ctgatcagg                              39


<210>  25
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ggcgccgccg ccctgcaggc caaccaggcc ctgatcaggg ccaagagcaa c                51


<210>  26
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
ggcgagcccg aggtggccaa gtgggccgag ggcctgaggg agaaggccgc cagcaac          57


<210>  27
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
gccgacaccg actacgccga cggcagcgag gacaaggtgg tggag                       45


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Asp Glu Lys Asp Ser Glu Ala Val Tyr Val Asp Gly Asp Thr 
1               5                   10                  


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  30
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gac                                                                     63


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gaacaaaaac tcatctcaga agaggatctg                                        30


<210>  33
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55              


<210>  34
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic

<400>  34
gctgcagcag ggggtggggg gtcaggtgga gggggatctg gcggtggagg cagcgggggc       60

ggaggctcag gcggtggcgg aagcggtggg ggaggctctg ggggaggcgg tagcggcggt      120

ggcggcagcg gtgggggcgg ctctgggggt ggtggtagtg gcggcggagg tagt            174


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  36
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ggtggtggcg gaagtggggg cggtggaagt ggtggaggtg ggtccggtgg aggtgggtcc       60


<210>  37
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
1               5                   10                  15      


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
            20                  25                  30          


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
        35                  40                  45              


Arg 
    


<210>  38
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
gctgtgggcc aggacacgca ggaggtcatc gtggtgccac actccttgcc ctttaaggtg       60

gtggtgatct cagccatcct ggccctggtg gtgctcacca tcatctccct tatcatcctc      120

atcatgcttt ggcagaagaa gccacgg                                          147


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ttctgctacg agaacgaggt g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
agaggcagat cctggaccta c                                                 21


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Gly Glu Asp Asp Leu Gln Asp Asn Gln Asp Leu Ile Arg Asp Lys Ser 
1               5                   10                  15      


Asn 
    


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Gly Glu Asp Asp Tyr Gln Asp Ala Gln Asp Leu Ile Arg Asp Lys Ser 
1               5                   10                  15      


Asn 
    


<210>  43
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Asp Lys Val Val Glu 
            20                  


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Phe Cys Tyr Glu Asn Glu Val 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Arg Gly Arg Ser Trp Thr Tyr 
1               5           


<210>  47
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
1               5                   10                  15      


Asp Ile Asn Val Gly Gly Ser Gly Phe Cys Tyr Glu Asn Glu Val 
            20                  25                  30      


<210>  48
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
aagagcagga tcaccagcga gggcgagtac atccccctgg accagatcga catcaacgtg       60

ggcggcagcg gcttctgcta cgagaacgag gtg                                    93


