                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Bhaduri, Aparna
       Di Lullo, Elizabeth
       Kriegstein, Arnold
 
<120>  METHODS FOR CULTURING CANCER CELLS AND FOR INHIBITING INVASION OF
        CANCER

<130>  UCSF-603WO

<150>  US 62/978,713
<151>  2020-02-19

<150>  US 62/956,508
<151>  2020-01-02

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2314
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
1               5                   10                  15      


Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
            20                  25                  30          


Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
        35                  40                  45              


Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
    50                  55                  60                  


Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
65                  70                  75                  80  


Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                85                  90                  95      


Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
            100                 105                 110         


Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
        115                 120                 125             


His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
    130                 135                 140                 


Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
145                 150                 155                 160 


Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                165                 170                 175     


Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
            180                 185                 190         


Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
        195                 200                 205             


Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
    210                 215                 220                 


Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
225                 230                 235                 240 


Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                245                 250                 255     


Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
            260                 265                 270         


Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
        275                 280                 285             


Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
    290                 295                 300                 


Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
305                 310                 315                 320 


Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                325                 330                 335     


Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
            340                 345                 350         


Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
        355                 360                 365             


Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
    370                 375                 380                 


Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
385                 390                 395                 400 


Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                405                 410                 415     


Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
            420                 425                 430         


Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
        435                 440                 445             


Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
    450                 455                 460                 


Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
465                 470                 475                 480 


Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                485                 490                 495     


Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
            500                 505                 510         


Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
        515                 520                 525             


His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
    530                 535                 540                 


Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
545                 550                 555                 560 


Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                565                 570                 575     


Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
            580                 585                 590         


Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
        595                 600                 605             


Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
    610                 615                 620                 


Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
625                 630                 635                 640 


Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                645                 650                 655     


Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
            660                 665                 670         


Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
        675                 680                 685             


Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
    690                 695                 700                 


Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
705                 710                 715                 720 


Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                725                 730                 735     


Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
            740                 745                 750         


Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu Val Phe 
        755                 760                 765             


Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn Thr Thr 
    770                 775                 780                 


Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro Val Phe 
785                 790                 795                 800 


Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr Asp Gly 
                805                 810                 815     


Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu Leu Phe 
            820                 825                 830         


Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr Ser Ala 
        835                 840                 845             


Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val Ala Gly 
    850                 855                 860                 


Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp Val Leu 
865                 870                 875                 880 


Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser Glu Ser 
                885                 890                 895     


Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro Pro Ser 
            900                 905                 910         


Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro Ser Tyr 
        915                 920                 925             


Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val Ser Tyr 
    930                 935                 940                 


Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr Gln Gly 
945                 950                 955                 960 


Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser Ser Leu 
                965                 970                 975     


Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu Ser Gly 
            980                 985                 990         


Asp Gly Glu Trp Ser Gly Ala Ser  Ser Asp Ser Glu Phe  Leu Leu Pro 
        995                 1000                 1005             


Asp Thr  Asp Gly Leu Thr Ala  Leu Asn Ile Ser Ser  Pro Val Ser 
    1010                 1015                 1020             


Val Ala  Glu Phe Thr Tyr Thr  Thr Ser Val Phe Gly  Asp Asp Asn 
    1025                 1030                 1035             


Lys Ala  Leu Ser Lys Ser Glu  Ile Ile Tyr Gly Asn  Glu Thr Glu 
    1040                 1045                 1050             


Leu Gln  Ile Pro Ser Phe Asn  Glu Met Val Tyr Pro  Ser Glu Ser 
    1055                 1060                 1065             


Thr Val  Met Pro Asn Met Tyr  Asp Asn Val Asn Lys  Leu Asn Ala 
    1070                 1075                 1080             


Ser Leu  Gln Glu Thr Ser Val  Ser Ile Ser Ser Thr  Lys Gly Met 
    1085                 1090                 1095             


Phe Pro  Gly Ser Leu Ala His  Thr Thr Thr Lys Val  Phe Asp His 
    1100                 1105                 1110             


Glu Ile  Ser Gln Val Pro Glu  Asn Asn Phe Ser Val  Gln Pro Thr 
    1115                 1120                 1125             


His Thr  Val Ser Gln Ala Ser  Gly Asp Thr Ser Leu  Lys Pro Val 
    1130                 1135                 1140             


Leu Ser  Ala Asn Ser Glu Pro  Ala Ser Ser Asp Pro  Ala Ser Ser 
    1145                 1150                 1155             


Glu Met  Leu Ser Pro Ser Thr  Gln Leu Leu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Ala Ser  Phe Ser Thr Glu Val  Leu Leu Gln Pro Ser  Phe Gln Ala 
    1175                 1180                 1185             


Ser Asp  Val Asp Thr Leu Leu  Lys Thr Val Leu Pro  Ala Val Pro 
    1190                 1195                 1200             


Ser Asp  Pro Ile Leu Val Glu  Thr Pro Lys Val Asp  Lys Ile Ser 
    1205                 1210                 1215             


Ser Thr  Met Leu His Leu Ile  Val Ser Asn Ser Ala  Ser Ser Glu 
    1220                 1225                 1230             


Asn Met  Leu His Ser Thr Ser  Val Pro Val Phe Asp  Val Ser Pro 
    1235                 1240                 1245             


Thr Ser  His Met His Ser Ala  Ser Leu Gln Gly Leu  Thr Ile Ser 
    1250                 1255                 1260             


Tyr Ala  Ser Glu Lys Tyr Glu  Pro Val Leu Leu Lys  Ser Glu Ser 
    1265                 1270                 1275             


Ser His  Gln Val Val Pro Ser  Leu Tyr Ser Asn Asp  Glu Leu Phe 
    1280                 1285                 1290             


Gln Thr  Ala Asn Leu Glu Ile  Asn Gln Ala His Pro  Pro Lys Gly 
    1295                 1300                 1305             


Arg His  Val Phe Ala Thr Pro  Val Leu Ser Ile Asp  Glu Pro Leu 
    1310                 1315                 1320             


Asn Thr  Leu Ile Asn Lys Leu  Ile His Ser Asp Glu  Ile Leu Thr 
    1325                 1330                 1335             


Ser Thr  Lys Ser Ser Val Thr  Gly Lys Val Phe Ala  Gly Ile Pro 
    1340                 1345                 1350             


Thr Val  Ala Ser Asp Thr Phe  Val Ser Thr Asp His  Ser Val Pro 
    1355                 1360                 1365             


Ile Gly  Asn Gly His Val Ala  Ile Thr Ala Val Ser  Pro His Arg 
    1370                 1375                 1380             


Asp Gly  Ser Val Thr Ser Thr  Lys Leu Leu Phe Pro  Ser Lys Ala 
    1385                 1390                 1395             


Thr Ser  Glu Leu Ser His Ser  Ala Lys Ser Asp Ala  Gly Leu Val 
    1400                 1405                 1410             


Gly Gly  Gly Glu Asp Gly Asp  Thr Asp Asp Asp Gly  Asp Asp Asp 
    1415                 1420                 1425             


Asp Asp  Arg Asp Ser Asp Gly  Leu Ser Ile His Lys  Cys Met Ser 
    1430                 1435                 1440             


Cys Ser  Ser Tyr Arg Glu Ser  Gln Glu Lys Val Met  Asn Asp Ser 
    1445                 1450                 1455             


Asp Thr  His Glu Asn Ser Leu  Met Asp Gln Asn Asn  Pro Ile Ser 
    1460                 1465                 1470             


Tyr Ser  Leu Ser Glu Asn Ser  Glu Glu Asp Asn Arg  Val Thr Ser 
    1475                 1480                 1485             


Val Ser  Ser Asp Ser Gln Thr  Gly Met Asp Arg Ser  Pro Gly Lys 
    1490                 1495                 1500             


Ser Pro  Ser Ala Asn Gly Leu  Ser Gln Lys His Asn  Asp Gly Lys 
    1505                 1510                 1515             


Glu Glu  Asn Asp Ile Gln Thr  Gly Ser Ala Leu Leu  Pro Leu Ser 
    1520                 1525                 1530             


Pro Glu  Ser Lys Ala Trp Ala  Val Leu Thr Ser Asp  Glu Glu Ser 
    1535                 1540                 1545             


Gly Ser  Gly Gln Gly Thr Ser  Asp Ser Leu Asn Glu  Asn Glu Thr 
    1550                 1555                 1560             


Ser Thr  Asp Phe Ser Phe Ala  Asp Thr Asn Glu Lys  Asp Ala Asp 
    1565                 1570                 1575             


Gly Ile  Leu Ala Ala Gly Asp  Ser Glu Ile Thr Pro  Gly Phe Pro 
    1580                 1585                 1590             


Gln Ser  Pro Thr Ser Ser Val  Thr Ser Glu Asn Ser  Glu Val Phe 
    1595                 1600                 1605             


His Val  Ser Glu Ala Glu Ala  Ser Asn Ser Ser His  Glu Ser Arg 
    1610                 1615                 1620             


Ile Gly  Leu Ala Glu Gly Leu  Glu Ser Glu Lys Lys  Ala Val Ile 
    1625                 1630                 1635             


Pro Leu  Val Ile Val Ser Ala  Leu Thr Phe Ile Cys  Leu Val Val 
    1640                 1645                 1650             


Leu Val  Gly Ile Leu Ile Tyr  Trp Arg Lys Cys Phe  Gln Thr Ala 
    1655                 1660                 1665             


His Phe  Tyr Leu Glu Asp Ser  Thr Ser Pro Arg Val  Ile Ser Thr 
    1670                 1675                 1680             


Pro Pro  Thr Pro Ile Phe Pro  Ile Ser Asp Asp Val  Gly Ala Ile 
    1685                 1690                 1695             


Pro Ile  Lys His Phe Pro Lys  His Val Ala Asp Leu  His Ala Ser 
    1700                 1705                 1710             


Ser Gly  Phe Thr Glu Glu Phe  Glu Thr Leu Lys Glu  Phe Tyr Gln 
    1715                 1720                 1725             


Glu Val  Gln Ser Cys Thr Val  Asp Leu Gly Ile Thr  Ala Asp Ser 
    1730                 1735                 1740             


Ser Asn  His Pro Asp Asn Lys  His Lys Asn Arg Tyr  Ile Asn Ile 
    1745                 1750                 1755             


Val Ala  Tyr Asp His Ser Arg  Val Lys Leu Ala Gln  Leu Ala Glu 
    1760                 1765                 1770             


Lys Asp  Gly Lys Leu Thr Asp  Tyr Ile Asn Ala Asn  Tyr Val Asp 
    1775                 1780                 1785             


Gly Tyr  Asn Arg Pro Lys Ala  Tyr Ile Ala Ala Gln  Gly Pro Leu 
    1790                 1795                 1800             


Lys Ser  Thr Ala Glu Asp Phe  Trp Arg Met Ile Trp  Glu His Asn 
    1805                 1810                 1815             


Val Glu  Val Ile Val Met Ile  Thr Asn Leu Val Glu  Lys Gly Arg 
    1820                 1825                 1830             


Arg Lys  Cys Asp Gln Tyr Trp  Pro Ala Asp Gly Ser  Glu Glu Tyr 
    1835                 1840                 1845             


Gly Asn  Phe Leu Val Thr Gln  Lys Ser Val Gln Val  Leu Ala Tyr 
    1850                 1855                 1860             


Tyr Thr  Val Arg Asn Phe Thr  Leu Arg Asn Thr Lys  Ile Lys Lys 
    1865                 1870                 1875             


Gly Ser  Gln Lys Gly Arg Pro  Ser Gly Arg Val Val  Thr Gln Tyr 
    1880                 1885                 1890             


His Tyr  Thr Gln Trp Pro Asp  Met Gly Val Pro Glu  Tyr Ser Leu 
    1895                 1900                 1905             


Pro Val  Leu Thr Phe Val Arg  Lys Ala Ala Tyr Ala  Lys Arg His 
    1910                 1915                 1920             


Ala Val  Gly Pro Val Val Val  His Cys Ser Ala Gly  Val Gly Arg 
    1925                 1930                 1935             


Thr Gly  Thr Tyr Ile Val Leu  Asp Ser Met Leu Gln  Gln Ile Gln 
    1940                 1945                 1950             


His Glu  Gly Thr Val Asn Ile  Phe Gly Phe Leu Lys  His Ile Arg 
    1955                 1960                 1965             


Ser Gln  Arg Asn Tyr Leu Val  Gln Thr Glu Glu Gln  Tyr Val Phe 
    1970                 1975                 1980             


Ile His  Asp Thr Leu Val Glu  Ala Ile Leu Ser Lys  Glu Thr Glu 
    1985                 1990                 1995             


Val Leu  Asp Ser His Ile His  Ala Tyr Val Asn Ala  Leu Leu Ile 
    2000                 2005                 2010             


Pro Gly  Pro Ala Gly Lys Thr  Lys Leu Glu Lys Gln  Phe Gln Leu 
    2015                 2020                 2025             


Leu Ser  Gln Ser Asn Ile Gln  Gln Ser Asp Tyr Ser  Ala Ala Leu 
    2030                 2035                 2040             


Lys Gln  Cys Asn Arg Glu Lys  Asn Arg Thr Ser Ser  Ile Ile Pro 
    2045                 2050                 2055             


Val Glu  Arg Ser Arg Val Gly  Ile Ser Ser Leu Ser  Gly Glu Gly 
    2060                 2065                 2070             


Thr Asp  Tyr Ile Asn Ala Ser  Tyr Ile Met Gly Tyr  Tyr Gln Ser 
    2075                 2080                 2085             


Asn Glu  Phe Ile Ile Thr Gln  His Pro Leu Leu His  Thr Ile Lys 
    2090                 2095                 2100             


Asp Phe  Trp Arg Met Ile Trp  Asp His Asn Ala Gln  Leu Val Val 
    2105                 2110                 2115             


Met Ile  Pro Asp Gly Gln Asn  Met Ala Glu Asp Glu  Phe Val Tyr 
    2120                 2125                 2130             


Trp Pro  Asn Lys Asp Glu Pro  Ile Asn Cys Glu Ser  Phe Lys Val 
    2135                 2140                 2145             


Thr Leu  Met Ala Glu Glu His  Lys Cys Leu Ser Asn  Glu Glu Lys 
    2150                 2155                 2160             


Leu Ile  Ile Gln Asp Phe Ile  Leu Glu Ala Thr Gln  Asp Asp Tyr 
    2165                 2170                 2175             


Val Leu  Glu Val Arg His Phe  Gln Cys Pro Lys Trp  Pro Asn Pro 
    2180                 2185                 2190             


Asp Ser  Pro Ile Ser Lys Thr  Phe Glu Leu Ile Ser  Val Ile Lys 
    2195                 2200                 2205             


Glu Glu  Ala Ala Asn Arg Asp  Gly Pro Met Ile Val  His Asp Glu 
    2210                 2215                 2220             


His Gly  Gly Val Thr Ala Gly  Thr Phe Cys Ala Leu  Thr Thr Leu 
    2225                 2230                 2235             


Met His  Gln Leu Glu Lys Glu  Asn Ser Val Asp Val  Tyr Gln Val 
    2240                 2245                 2250             


Ala Lys  Met Ile Asn Leu Met  Arg Pro Gly Val Phe  Ala Asp Ile 
    2255                 2260                 2265             


Glu Gln  Tyr Gln Phe Leu Tyr  Lys Val Ile Leu Ser  Leu Val Ser 
    2270                 2275                 2280             


Thr Arg  Gln Glu Glu Asn Pro  Ser Thr Ser Leu Asp  Ser Asn Gly 
    2285                 2290                 2295             


Ala Ala  Leu Pro Asp Gly Asn  Ile Ala Glu Ser Leu  Glu Ser Leu 
    2300                 2305                 2310             


Val 
    


<210>  2
<211>  7941
<212>  DNA
<213>  Homo sapiens

<400>  2
cacacatacg cacgcacgat ctcacttcga tctatacact ggaggattaa aacaaacaaa       60

caaaaaaaac atttccttcg ctccccctcc ctctccactc tgagaagcag aggagccgca      120

cggcgagggg ccgcagaccg tctggaaatg cgaatcctaa agcgtttcct cgcttgcatt      180

cagctcctct gtgtttgccg cctggattgg gctaatggat actacagaca acagagaaaa      240

cttgttgaag agattggctg gtcctataca ggagcactga atcaaaaaaa ttggggaaag      300

aaatatccaa catgtaatag cccaaaacaa tctcctatca atattgatga agatcttaca      360

caagtaaatg tgaatcttaa gaaacttaaa tttcagggtt gggataaaac atcattggaa      420

aacacattca ttcataacac tgggaaaaca gtggaaatta atctcactaa tgactaccgt      480

gtcagcggag gagtttcaga aatggtgttt aaagcaagca agataacttt tcactgggga      540

aaatgcaata tgtcatctga tggatcagag catagtttag aaggacaaaa atttccactt      600

gagatgcaaa tctactgctt tgatgcggac cgattttcaa gttttgagga agcagtcaaa      660

ggaaaaggga agttaagagc tttatccatt ttgtttgagg ttgggacaga agaaaatttg      720

gatttcaaag cgattattga tggagtcgaa agtgttagtc gttttgggaa gcaggctgct      780

ttagatccat tcatactgtt gaaccttctg ccaaactcaa ctgacaagta ttacatttac      840

aatggctcat tgacatctcc tccctgcaca gacacagttg actggattgt ttttaaagat      900

acagttagca tctctgaaag ccagttggct gttttttgtg aagttcttac aatgcaacaa      960

tctggttatg tcatgctgat ggactactta caaaacaatt ttcgagagca acagtacaag     1020

ttctctagac aggtgttttc ctcatacact ggaaaggaag agattcatga agcagtttgt     1080

agttcagaac cagaaaatgt tcaggctgac ccagagaatt ataccagcct tcttgttaca     1140

tgggaaagac ctcgagtcgt ttatgatacc atgattgaga agtttgcagt tttgtaccag     1200

cagttggatg gagaggacca aaccaagcat gaatttttga cagatggcta tcaagacttg     1260

ggtgctattc tcaataattt gctacccaat atgagttatg ttcttcagat agtagccata     1320

tgcactaatg gcttatatgg aaaatacagc gaccaactga ttgtcgacat gcctactgat     1380

aatcctgaac ttgatctttt ccctgaatta attggaactg aagaaataat caaggaggag     1440

gaagagggaa aagacattga agaaggcgct attgtgaatc ctggtagaga cagtgctaca     1500

aaccaaatca ggaaaaagga accccagatt tctaccacaa cacactacaa tcgcataggg     1560

acgaaataca atgaagccaa gactaaccga tccccaacaa gaggaagtga attctctgga     1620

aagggtgatg ttcccaatac atctttaaat tccacttccc aaccagtcac taaattagcc     1680

acagaaaaag atatttcctt gacttctcag actgtgactg aactgccacc tcacactgtg     1740

gaaggtactt cagcctcttt aaatgatggc tctaaaactg ttcttagatc tccacatatg     1800

aacttgtcgg ggactgcaga atccttaaat acagtttcta taacagaata tgaggaggag     1860

agtttattga ccagtttcaa gcttgatact ggagctgaag attcttcagg ctccagtccc     1920

gcaacttctg ctatcccatt catctctgag aacatatccc aagggtatat attttcctcc     1980

gaaaacccag agacaataac atatgatgtc cttataccag aatctgctag aaatgcttcc     2040

gaagattcaa cttcatcagg ttcagaagaa tcactaaagg atccttctat ggagggaaat     2100

gtgtggtttc ctagctctac agacataaca gcacagcccg atgttggatc aggcagagag     2160

agctttctcc agactaatta cactgagata cgtgttgatg aatctgagaa gacaaccaag     2220

tccttttctg caggcccagt gatgtcacag ggtccctcag ttacagatct ggaaatgcca     2280

cattattcta cctttgccta cttcccaact gaggtaacac ctcatgcttt taccccatcc     2340

tccagacaac aggatttggt ctccacggtc aacgtggtat actcgcagac aacccaaccg     2400

gtatacaatg gtgagacacc tcttcaacct tcctacagta gtgaagtctt tcctctagtc     2460

acccctttgt tgcttgacaa tcagatcctc aacactaccc ctgctgcttc aagtagtgat     2520

tcggccttgc atgctacgcc tgtatttccc agtgtcgatg tgtcatttga atccatcctg     2580

tcttcctatg atggtgcacc tttgcttcca ttttcctctg cttccttcag tagtgaattg     2640

tttcgccatc tgcatacagt ttctcaaatc cttccacaag ttacttcagc taccgagagt     2700

gataaggtgc ccttgcatgc ttctctgcca gtggctgggg gtgatttgct attagagccc     2760

agccttgctc agtattctga tgtgctgtcc actactcatg ctgcttcaga gacgctggaa     2820

tttggtagtg aatctggtgt tctttataaa acgcttatgt tttctcaagt tgaaccaccc     2880

agcagtgatg ccatgatgca tgcacgttct tcagggcctg aaccttctta tgccttgtct     2940

gataatgagg gctcccaaca catcttcact gtttcttaca gttctgcaat acctgtgcat     3000

gattctgtgg gtgtaactta tcagggttcc ttatttagcg gccctagcca tataccaata     3060

cctaagtctt cgttaataac cccaactgca tcattactgc agcctactca tgccctctct     3120

ggtgatgggg aatggtctgg agcctcttct gatagtgaat ttcttttacc tgacacagat     3180

gggctgacag cccttaacat ttcttcacct gtttctgtag ctgaatttac atatacaaca     3240

tctgtgtttg gtgatgataa taaggcgctt tctaaaagtg aaataatata tggaaatgag     3300

actgaactgc aaattccttc tttcaatgag atggtttacc cttctgaaag cacagtcatg     3360

cccaacatgt atgataatgt aaataagttg aatgcgtctt tacaagaaac ctctgtttcc     3420

atttctagca ccaagggcat gtttccaggg tcccttgctc ataccaccac taaggttttt     3480

gatcatgaga ttagtcaagt tccagaaaat aacttttcag ttcaacctac acatactgtc     3540

tctcaagcat ctggtgacac ttcgcttaaa cctgtgctta gtgcaaactc agagccagca     3600

tcctctgacc ctgcttctag tgaaatgtta tctccttcaa ctcagctctt attttatgag     3660

acctcagctt cttttagtac tgaagtattg ctacaacctt cctttcaggc ttctgatgtt     3720

gacaccttgc ttaaaactgt tcttccagct gtgcccagtg atccaatatt ggttgaaacc     3780

cccaaagttg ataaaattag ttctacaatg ttgcatctca ttgtatcaaa ttctgcttca     3840

agtgaaaaca tgctgcactc tacatctgta ccagtttttg atgtgtcgcc tacttctcat     3900

atgcactctg cttcacttca aggtttgacc atttcctatg caagtgagaa atatgaacca     3960

gttttgttaa aaagtgaaag ttcccaccaa gtggtacctt ctttgtacag taatgatgag     4020

ttgttccaaa cggccaattt ggagattaac caggcccatc ccccaaaagg aaggcatgta     4080

tttgctacac ctgttttatc aattgatgaa ccattaaata cactaataaa taagcttata     4140

cattccgatg aaattttaac ctccaccaaa agttctgtta ctggtaaggt atttgctggt     4200

attccaacag ttgcttctga tacatttgta tctactgatc attctgttcc tataggaaat     4260

gggcatgttg ccattacagc tgtttctccc cacagagatg gttctgtaac ctcaacaaag     4320

ttgctgtttc cttctaaggc aacttctgag ctgagtcata gtgccaaatc tgatgccggt     4380

ttagtgggtg gtggtgaaga tggtgacact gatgatgatg gtgatgatga tgatgacaga     4440

gatagtgatg gcttatccat tcataagtgt atgtcatgct catcctatag agaatcacag     4500

gaaaaggtaa tgaatgattc agacacccac gaaaacagtc ttatggatca gaataatcca     4560

atctcatact cactatctga gaattctgaa gaagataata gagtcacaag tgtatcctca     4620

gacagtcaaa ctggtatgga cagaagtcct ggtaaatcac catcagcaaa tgggctatcc     4680

caaaagcaca atgatggaaa agaggaaaat gacattcaga ctggtagtgc tctgcttcct     4740

ctcagccctg aatctaaagc atgggcagtt ctgacaagtg atgaagaaag tggatcaggg     4800

caaggtacct cagatagcct taatgagaat gagacttcca cagatttcag ttttgcagac     4860

actaatgaaa aagatgctga tgggatcctg gcagcaggtg actcagaaat aactcctgga     4920

ttcccacagt ccccaacatc atctgttact agcgagaact cagaagtgtt ccacgtttca     4980

gaggcagagg ccagtaatag tagccatgag tctcgtattg gtctagctga ggggttggaa     5040

tccgagaaga aggcagttat accccttgtg atcgtgtcag ccctgacttt tatctgtcta     5100

gtggttcttg tgggtattct catctactgg aggaaatgct tccagactgc acacttttac     5160

ttagaggaca gtacatcccc tagagttata tccacacctc caacacctat ctttccaatt     5220

tcagatgatg tcggagcaat tccaataaag cactttccaa agcatgttgc agatttacat     5280

gcaagtagtg ggtttactga agaatttgag acactgaaag agttttacca ggaagtgcag     5340

agctgtactg ttgacttagg tattacagca gacagctcca accacccaga caacaagcac     5400

aagaatcgat acataaatat cgttgcctat gatcatagca gggttaagct agcacagctt     5460

gctgaaaagg atggcaaact gactgattat atcaatgcca attatgttga tggctacaac     5520

agaccaaaag cttatattgc tgcccaaggc ccactgaaat ccacagctga agatttctgg     5580

agaatgatat gggaacataa tgtggaagtt attgtcatga taacaaacct cgtggagaaa     5640

ggaaggagaa aatgtgatca gtactggcct gccgatggga gtgaggagta cgggaacttt     5700

ctggtcactc agaagagtgt gcaagtgctt gcctattata ctgtgaggaa ttttactcta     5760

agaaacacaa aaataaaaaa gggctcccag aaaggaagac ccagtggacg tgtggtcaca     5820

cagtatcact acacgcagtg gcctgacatg ggagtaccag agtactccct gccagtgctg     5880

acctttgtga gaaaggcagc ctatgccaag cgccatgcag tggggcctgt tgtcgtccac     5940

tgcagtgctg gagttggaag aacaggcaca tatattgtgc tagacagtat gttgcagcag     6000

attcaacacg aaggaactgt caacatattt ggcttcttaa aacacatccg ttcacaaaga     6060

aattatttgg tacaaactga ggagcaatat gtcttcattc atgatacact ggttgaggcc     6120

atacttagta aagaaactga ggtgctggac agtcatattc atgcctatgt taatgcactc     6180

ctcattcctg gaccagcagg caaaacaaag ctagagaaac aattccagct cctgagccag     6240

tcaaatatac agcagagtga ctattctgca gccctaaagc aatgcaacag ggaaaagaat     6300

cgaacttctt ctatcatccc tgtggaaaga tcaagggttg gcatttcatc cctgagtgga     6360

gaaggcacag actacatcaa tgcctcctat atcatgggct attaccagag caatgaattc     6420

atcattaccc agcaccctct ccttcatacc atcaaggatt tctggaggat gatatgggac     6480

cataatgccc aactggtggt tatgattcct gatggccaaa acatggcaga agatgaattt     6540

gtttactggc caaataaaga tgagcctata aattgtgaga gctttaaggt cactcttatg     6600

gctgaagaac acaaatgtct atctaatgag gaaaaactta taattcagga ctttatctta     6660

gaagctacac aggatgatta tgtacttgaa gtgaggcact ttcagtgtcc taaatggcca     6720

aatccagata gccccattag taaaactttt gaacttataa gtgttataaa agaagaagct     6780

gccaataggg atgggcctat gattgttcat gatgagcatg gaggagtgac ggcaggaact     6840

ttctgtgctc tgacaaccct tatgcaccaa ctagaaaaag aaaattccgt ggatgtttac     6900

caggtagcca agatgatcaa tctgatgagg ccaggagtct ttgctgacat tgagcagtat     6960

cagtttctct acaaagtgat cctcagcctt gtgagcacaa ggcaggaaga gaatccatcc     7020

acctctctgg acagtaatgg tgcagcattg cctgatggaa atatagctga gagcttagag     7080

tctttagttt aacacagaaa ggggtggggg gactcacatc tgagcattgt tttcctcttc     7140

ctaaaattag gcaggaaaat cagtctagtt ctgttatctg ttgatttccc atcacctgac     7200

agtaactttc atgacatagg attctgccgc caaatttata tcattaacaa tgtgtgcctt     7260

tttgcaagac ttgtaattta cttattatgt ttgaactaaa atgattgaat tttacagtat     7320

ttctaagaat ggaattgtgg tatttttttc tgtattgatt ttaacagaaa atttcaattt     7380

atagaggtta ggaattccaa actacagaaa atgtttgttt ttagtgtcaa atttttagct     7440

gtatttgtag caattatcag gtttgctaga aatataactt ttaatacagt agcctgtaaa     7500

taaaacactc ttccatatga tattcaacat tttacaactg cagtattcac ctaaagtaga     7560

aataatctgt tacttattgt aaatactgcc ctagtgtctc catggaccaa atttatattt     7620

ataattgtag atttttatat tttactactg agtcaagttt tctagttctg tgtaattgtt     7680

tagtttaatg acgtagttca ttagctggtc ttactctacc agttttctga cattgtattg     7740

tgttacctaa gtcattaact ttgtttcagc atgtaatttt aacttttgtg gaaaatagaa     7800

ataccttcat tttgaaagaa gtttttatga gaataacacc ttaccaaaca ttgttcaaat     7860

ggtttttatc caaggaattg caaaaataaa tataaatatt gccattaaaa aaaaaaaaaa     7920

aaaaaaaaaa aaaaaaaaaa a                                               7941


<210>  3
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 
        35                  40                  45              


Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 
    50                  55                  60                  


Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 
65                  70                  75                  80  


Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 
                85                  90                  95      


Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 
            100                 105                 110         


Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 
        115                 120                 125             


Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 
    130                 135                 140                 


Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 
145                 150                 155                 160 


Lys Lys Gln Glu Lys Met Leu Asp 
                165             


<210>  4
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  4
attctccatt tcccttccgt tccctccctg tcagggcgta attgagtcaa aggcaggatc       60

aggttccccg ccttccagtc caaaaatccc gccaagagag ccccagagca gaggaaaatc      120

caaagtggag agaggggaag aaagagacca gtgagtcatc cgtccagaag gcggggagag      180

cagcagcggc ccaagcagga gctgcagcga gccgggtacc tggactcagc ggtagcaacc      240

tcgccccttg caacaaaggc agactgagcg ccagagagga cgtttccaac tcaaaaatgc      300

aggctcaaca gtaccagcag cagcgtcgaa aatttgcagc tgccttcttg gcattcattt      360

tcatactggc agctgtggat actgctgaag cagggaagaa agagaaacca gaaaaaaaag      420

tgaagaagtc tgactgtgga gaatggcagt ggagtgtgtg tgtgcccacc agtggagact      480

gtgggctggg cacacgggag ggcactcgga ctggagctga gtgcaagcaa accatgaaga      540

cccagagatg taagatcccc tgcaactgga agaagcaatt tggcgcggag tgcaaatacc      600

agttccaggc ctggggagaa tgtgacctga acacagccct gaagaccaga actggaagtc      660

tgaagcgagc cctgcacaat gccgaatgcc agaagactgt caccatctcc aagccctgtg      720

gcaaactgac caagcccaaa cctcaagcag aatctaagaa gaagaaaaag gaaggcaaga      780

aacaggagaa gatgctggat taaaagatgt cacctgtgga acataaaaag gacatcagca      840

aacaggatca gttaactatt gcatttatat gtaccgtagg ctttgtattc aaaaattatc      900

tatagctaag tacacaataa gcaaaaacaa aaagaaaaga aaatttttgt agtagcgttt      960

tttaaatgta tactatagta ccagtagggg cttataataa aggactgtaa tcttatttag     1020

gaagttgact tatagtacat gataaatgat agacaattga ggtaagtttt ttgaaattat     1080

gtgacatttt acattaaatt ttttttacat tttttgggca gcaatttaaa tgttatgact     1140

atgtaaacta cttctcttgt taggtaattt ttttcaccta gatttttttc ccaattgaga     1200

aaaatatata ctaaacaaaa tagcaataaa acataatcac tctatttgaa gaaaatatct     1260

tgttttctgc caatagattt tttaaaatgt agtcagcaaa atgggggtgg ggaagcagag     1320

catgtcctag ttcaatgttg actttttttt tttttaaaga aaagcattaa gacataaaat     1380

tctttcactt tggcagaagc atttgttttc ttgatgaaat tatttttcca tctgaggaaa     1440

aaaatactag gaaaataaat caaggtgatg ctgaaaaaaa aa                        1482


<210>  5
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5
ccggccagac aacaagcaca agaatctcga gattcttgtg cttgttgtct ggttttt          57


<210>  6
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6
ccggaggcaa gaaacaggag aagatctcga gatcttctcc tgtttcttgc ctttttt          57


