﻿               SEQUENCE LISTING

<110> Deutsches Herzzentrum München

<120> Diagnosis of an aortic dissection by detecting a specific biomarker in a blood sample

<130> D31705WO

<150> EP20 151 237.3
<151> 2020-01-10

<160> 3

<170> BiSSAP 1.3.6

<210> 1
<211> 8543
<212> DNA
<213> Homo sapiens


<220> 
<223> NM_001135.3 aggrecan core protein isoform 1 precursor

<400> 1
cacctacctc cccgccgctc cagagggggc tcgcagagct gaggacgcgc gcagcgctgc       60

tcaaggtctc tctctctcag caccctcgcc ggccggcgtc tgacgcgggt gccagggtct      120

ccgggcacct ttcagtgtcc attccctcag ccagccagga ctccgcaacc cagcagttgc      180

cgctgcggcc acagcccgag gggacctgcg gacaggacgc cggcaggagg aggggtgcgc      240

agcgcccgcg cagagcgtct ccctcgctac gcagcgagac ccgggcctcc cggccccagg      300

agcccccagc tgcctcgcca ggtgtgtggg actgaagttc ttggagaagg gagtccaact      360

cttcaaggtg aactatgacc actttactct gggttttcgt gactctgagg gtcatcactg      420

cagctgtcac tgtagaaact tcagaccatg acaactcgct gagtgtcagc atcccccaac      480

cgtccccgct gagggtcctc ctggggacct ccctcaccat cccctgctat ttcatcgacc      540

ccatgcaccc tgtgaccacc gccccttcta ccgccccact ggccccaaga atcaagtgga      600

gccgtgtgtc caaggagaag gaggtagtgc tgctggtggc cactgaaggg cgcgtgcggg      660

tcaacagtgc ctatcaggac aaggtctcac tgcccaacta cccggccatc cccagtgacg      720

ccaccttgga agtccagagc ctgcgctcca atgactctgg ggtctaccgc tgcgaggtga      780

tgcatggcat cgaggacagc gaggccaccc tggaagtcgt ggtgaaaggc atcgtgttcc      840

attacagagc catctctaca cgctacaccc tcgactttga cagggcgcag cgggcctgcc      900

tgcagaacag tgccatcatt gccacgcctg agcagctgca ggccgcctac gaagacggct      960

tccaccagtg tgacgccggc tggctggctg accagactgt cagatacccc atccacactc     1020

cccgggaagg ctgctatgga gacaaggatg agtttcctgg tgtgaggacg tatggcatcc     1080

gagacaccaa cgagacctat gatgtgtact gcttcgccga ggagatggag ggtgaggtct     1140

tttatgcaac atctccagag aagttcacct tccaggaagc agccaatgag tgccggcggc     1200

tgggtgcccg gctggccacc acgggccagc tctacctggc ctggcaggct ggcatggaca     1260

tgtgcagcgc cggctggctg gccgaccgca gcgtgcgcta ccccatctcc aaggcccggc     1320

ccaactgcgg tggcaacctc ctgggcgtga ggaccgtcta cgtgcatgcc aaccagacgg     1380

gctaccccga cccctcatcc cgctacgacg ccatctgcta cacaggtgaa gactttgtgg     1440

acatcccaga aaacttcttt ggagtggggg gtgaggagga catcaccgtc cagacagtga     1500

cctggcctga catggagctg ccactgcctc gaaacatcac tgagggtgaa gcccgaggca     1560

gcgtgatcct taccgtaaag cccatcttcg aggtctcccc cagtcccctg gaacccgagg     1620

agcccttcac gtttgcccct gaaatagggg ccactgcctt cgctgaggtt gagaatgaga     1680

ctggagaggc caccaggccc tggggctttc ccacacctgg cctgggccct gccacggcat     1740

tcaccagtga ggacctcgtc gtgcaggtga ccgctgtccc tgggcagccg catttgccag     1800

ggggggtcgt cttccactac cgcccgggac ccacccgcta ctcgctgacc tttgaggagg     1860

cacagcaggc ctgcctgcgc acgggggcgg tcattgcctc gccggagcag ctccaggccg     1920

cctacgaagc aggctatgag cagtgtgacg ccggctggct gcgggaccag accgtcagat     1980

accccattgt gagcccccgg accccatgcg tgggtgacaa ggacagcagc ccaggggtca     2040

ggacctatgg cgtgcgccca tcaacagaga cctacgatgt ctactgcttt gtagacagac     2100

ttgaggggga ggtgttcttc gccacacgcc ttgagcagtt caccttccag gaagcactgg     2160

agttctgtga atctcacaat gctacgctgg ccaccacggg ccagctctac gccgcctgga     2220

gccgcggcct ggacaagtgc tatgccggct ggctggccga cggcagcctc cgctacccca     2280

tcgtcacccc aaggcctgcc tgcggtgggg acaagccagg cgtgagaacg gtctacctct     2340

accctaacca gacgggcctc ccagacccac tgtcccggca ccatgccttc tgcttccgag     2400

gcatttcagc ggttccttct ccaggagaag aagagggtgg cacacccaca tcaccctctg     2460

gtgtggagga gtggatcgtg acccaagtgg ttcctggtgt ggctgctgtc cccgtagaag     2520

aggagacaac tgctgtaccc tcaggggaga ctactgccat cctagagttc accaccgagc     2580

cagaaaacca gacagaatgg gaaccagcct ataccccagt gggcacatcc ccgctgccag     2640

ggatccttcc tacttggcct cccactggcg cagcaacaga ggaaagtaca gaaggccctt     2700

ctgcaactga agtgccctct gcctcagagg aaccatcccc ctcagaggtg ccattcccct     2760

cagaggagcc atccccctca gaggaaccat tcccctcagt gaggccattc ccctcagtgg     2820

agctgttccc ctcagaggag ccattcccct ccaaggagcc atccccctca gaggaaccat     2880

cagcctcgga agagccgtat acaccttcac cccccgtgcc cagctggact gagctgccca     2940

gctctgggga ggaatctggg gcccctgatg tcagtggtga cttcacaggc agtggagatg     3000

tttcaggaca ccttgacttc agtgggcagc tgtcagggga cagggcaagt ggactgccct     3060

ctggagacct ggactccagt ggtcttactt ccacagtggg ctcaggcctg cctgtggaaa     3120

gtggactacc ctcaggggat gaagagagaa ttgagtggcc cagcactcct acggttggtg     3180

aactgccctc tggagctgag atcctagagg gctctgcctc tggagttggg gatctcagtg     3240

gacttccttc tggagaagtt ctagagacct ctgcctctgg agtaggagac ctcagtgggc     3300

ttccttctgg agaagttcta gagaccactg cccctggagt agaggacatc agcgggcttc     3360

cttctggaga agttctagag accactgccc ctggagtaga ggacatcagc gggcttcctt     3420

ctggagaagt tctagagacc actgcccctg gagtagagga catcagcggg cttccttctg     3480

gagaagttct agagaccact gcccctggag tagaggacat cagcgggctt ccttctggag     3540

aagttctaga gaccactgcc cctggagtag aggacatcag cgggcttcct tctggagaag     3600

ttctagagac cactgcccct ggagtagagg acatcagcgg gcttccttct ggagaagttc     3660

tagagaccgc tgcccctgga gtagaggaca tcagcgggct tccttctgga gaagttctag     3720

agaccgctgc ccctggagta gaggacatca gcgggcttcc ttctggagaa gttctagaga     3780

ccgctgcccc tggagtagag gacatcagcg ggcttccttc tggagaagtt ctagagaccg     3840

ctgcccctgg agtagaggac atcagcgggc ttccttctgg agaagttcta gagaccgctg     3900

cccctggagt agaggacatc agcgggcttc cttctggaga agttctagag accgctgccc     3960

ctggagtaga ggacatcagc gggcttcctt ctggagaagt tctagagacc gctgcccctg     4020

gagtagagga catcagcggg cttccttctg gagaagttct agagactgct gcccctggag     4080

tagaggacat cagcgggctt ccttctggag aagttctaga gactgctgcc cctggagtag     4140

aggacatcag cgggcttcct tctggagaag ttctagagac tgctgcccct ggagtagagg     4200

acatcagcgg gcttccttct ggagaagttc tagagactgc tgcccctgga gtagaggaca     4260

tcagcgggct tccttctgga gaagttctag agactgctgc ccctggagta gaggacatca     4320

gcgggcttcc ttctggagaa gttctagaga ctgctgcccc tggagtagag gacatcagcg     4380

ggcttccttc tggagaagtt ctagagactg ctgcccctgg agtagaggac atcagcgggc     4440

ttccttctgg agaagttcta gagactgctg cccctggagt agaggacatc agcgggcttc     4500

cttctggaga agttctagag actgctgccc ctggagtaga ggacatcagc gggcttcctt     4560

ctggagaagt tctagagact actgcccctg gagtagagga gatcagcggg cttccttctg     4620

gagaagttct agagactact gcccctggag tagatgagat cagtgggctt ccttctggag     4680

aagttctaga gactactgcc cctggagtag aggagatcag cgggcttcct tctggagaag     4740

ttctagagac ttctacctct gcggtagggg acctcagtgg acttccttct ggaggagaag     4800

ttctagagat ttctgtctct ggagtagagg acatcagtgg gcttccttct ggagaggttg     4860

tagagacttc tgcctctgga atagaggatg tcagtgaact tccttcagga gaaggtctag     4920

agacctctgc ttctggagta gaggacctca gcaggctccc ttctggagaa gaagttctag     4980

agatttctgc ctctggattt ggggacctca gtggacttcc ttctggagga gaaggtctag     5040

agacctctgc ttctgaagta gggactgacc tcagtgggct tccttctgga agggagggtc     5100

tagagacttc agcttctgga gctgaggacc tcagtgggtt gccttctgga aaagaagact     5160

tggtggggtc agcttctgga gacttggact tgggcaaact gccttctgga actctaggaa     5220

gtgggcaagc tccagaaaca agtggtcttc cctctggatt tagtggtgag tattctgggg     5280

tggaccttgg aagtggccca ccctctggcc tgcctgactt tagtggactt ccatctggat     5340

tcccaactgt ttccctagtg gattctacat tggtggaagt ggtcacagcc tccactgcaa     5400

gtgaactgga agggagggga accattggca tcagtggtgc aggagaaata tctggactgc     5460

cctccagtga gctggacatt agtgggagag ctagtggact cccttcagga actgaactca     5520

gtggccaagc atctgggtct cctgatgtca gtggggaaat acctggactc tttggtgtca     5580

gtggacagcc atcagggttt cctgacacta gtggggaaac atctggagtg actgagctta     5640

gcgggctgtc ctctggacaa ccaggtatta gtggagaagc atctggagtt ctttatggca     5700

ctagtcaacc ctttggcata actgatctga gtggagaaac atctggggtc cctgatctca     5760

gtgggcagcc ttcagggtta ccagggttca gtggggcaac atcaggagtc cctgacctgg     5820

tttctggtac cacgagtggc agcggtgaat cttctgggat tacatttgtg gacaccagtt     5880

tggttgaagt ggcccctact acatttaaag aagaagaagg cttagggtct gtggaactca     5940

gtggcctccc ttccggagag gcagatctgt caggcaaatc tgggatggtg gatgtcagtg     6000

gacagttttc tggaacagtc gattccagtg ggtttacatc ccagactccg gaattcagtg     6060

gcctaccaag tggcatagct gaggtcagtg gagaatcctc cagagctgag attgggagca     6120

gcctgccctc gggagcatat tatggcagtg gaactccatc tagtttcccc actgtctctc     6180

ttgtagacag aactttggtg gaatctgtaa cccaggctcc aacagcccaa gaggcaggag     6240

aagggccttc tggcatttta gaactcagtg gtgctcattc tggagcacca gacatgtctg     6300

gggagcattc tggatttctg gacctaagtg ggctgcagtc cgggctgata gagcccagcg     6360

gagagccacc aggtactcca tattttagtg gggattttgc cagcaccacc aatgtaagtg     6420

gagaatcctc tgtagccatg ggcaccagtg gagaggcctc aggacttcca gaagttactt     6480

taatcacttc tgagttcgtg gagggtgtta ctgaaccaac tatttctcag gaactaggcc     6540

aaaggccccc tgtgacacac acaccccagc tttttgagtc cagtggaaaa gtctccacag     6600

ctggggacat tagtggagct accccagtgc tccctgggtc tggagtagaa gtatcatcag     6660

tcccagaatc tagcagtgag acgtccgcct atcctgaagc tgggttcggg gcatctgccg     6720

cccctgaggc cagcagagaa gattctgggt cccctgatct gagtgaaacc acctctgcat     6780

tccacgaagc taaccttgag agatcctctg gcctaggagt gagcggcagc actttgacat     6840

ttcaagaagg cgaggcgtcc gctgccccag aagtgagtgg agaatccacc accaccagtg     6900

atgtggggac agaggcacca ggcttgcctt cagccactcc cacggcttct ggagacagga     6960

ctgaaatcag cggagacctg tctggtcaca cctcgcagct gggcgttgtc atcagcacca     7020

gcatcccaga gtctgagtgg acccagcaga cccagcgccc tgcagagacg catctagaaa     7080

ttgagtcctc aagcctcctg tactcaggag aagagactca cacagtcgaa acagccacct     7140

ccccaacaga tgcttccatc ccagcttctc cggaatggaa acgtgaatca gaatcaactg     7200

ctgcagacca ggaggtatgt gaggagggct ggaacaagta ccagggccac tgttaccgcc     7260

acttcccgga ccgcgagacc tgggtggatg ctgagcgccg gtgtcgggag cagcagtcac     7320

acctgagcag catcgtcacc cccgaggagc aggagtttgt caacaacaat gcccaagact     7380

accagtggat cggcctgaac gacaggacca tcgaagggga cttccgctgg tcagatggac     7440

accccatgca atttgagaac tggcgcccca accagcctga caactttttt gccgctggag     7500

aggactgtgt ggtgatgatc tggcacgaga agggcgagtg gaatgatgtt ccctgcaatt     7560

accacctccc cttcacgtgt aaaaagggca cagccaccac ctacaaacgc agactacaga     7620

agcggagctc acggcaccct cggaggagcc gccccagcac agcccactga gaagagcttc     7680

caggacgcac ccaggacgct gagcccagga gcctgccagg ctgacgtgca tcccacccag     7740

acggtgtcct cttcttgtcg ctttttgtca tataaggaat cccattaaag aaggaaaaaa     7800

ataaatccca catttgtgta tgcacccact cacccctcca aatcagcaaa accgcatcta     7860

atttgtccgc cgaatgccaa agcaaagcaa acttattata acccttggac tgagtttaga     7920

gacatttctt caatttccca tcgtgccttt ccagggacca gtgcagggac agggggagaa     7980

ggggaggggt taagttaaat aaagaagatt atttttgttt cctgacttta tccaagagca     8040

gtgcaatcgt tggttatttc acctccaggg agagctaggg aggagggagg agggctccaa     8100

aggagctgga aggagcagag gcctgagagc aggaagaact cggaaccgca gctgaatgta     8160

ttggatgaga aggagccagg agggctacac catctgtatg agggaaaagc cttgggggag     8220

aggggtgggt tcctgcctcc tgccgagggt aagccggcag gagagagcca tcagagggac     8280

ctccgctgcc tgggagttgg gttccctcca agggtccctc tttcagtgtc ctctctctca     8340

cctgggtctg ccaccctaac aggtggcaac tcggcagggc tgctgggggc acttcctgcc     8400

cagtgggggg tgccgcccaa ccttctcccc tccccacccc cgcccccggg accgtgcagg     8460

caccagggtt ccgtgcacct atttatattt ttgaaaactg aagattataa tattataata     8520

ataataaaga cattggaaga gat                                             8543


<210> 2
<211> 8840
<212> DNA
<213> Homo sapiens


<220> 
<223> NM_013227.3 aggrecan core protein isoform 2 precursor

<400> 2
cacctacctc cccgccgctc cagagggggc tcgcagagct gaggacgcgc gcagcgctgc       60

tcaaggtctc tctctctcag caccctcgcc ggccggcgtc tgacgcgggt gccagggtct      120

ccgggcacct ttcagtgtcc attccctcag ccagccagga ctccgcaacc cagcagttgc      180

cgctgcggcc acagcccgag gggacctgcg gacaggacgc cggcaggagg aggggtgcgc      240

agcgcccgcg cagagcgtct ccctcgctac gcagcgagac ccgggcctcc cggccccagg      300

agcccccagc tgcctcgcca ggtgtgtggg actgaagttc ttggagaagg gagtccaact      360

cttcaaggtg aactatgacc actttactct gggttttcgt gactctgagg gtcatcactg      420

cagctgtcac tgtagaaact tcagaccatg acaactcgct gagtgtcagc atcccccaac      480

cgtccccgct gagggtcctc ctggggacct ccctcaccat cccctgctat ttcatcgacc      540

ccatgcaccc tgtgaccacc gccccttcta ccgccccact ggccccaaga atcaagtgga      600

gccgtgtgtc caaggagaag gaggtagtgc tgctggtggc cactgaaggg cgcgtgcggg      660

tcaacagtgc ctatcaggac aaggtctcac tgcccaacta cccggccatc cccagtgacg      720

ccaccttgga agtccagagc ctgcgctcca atgactctgg ggtctaccgc tgcgaggtga      780

tgcatggcat cgaggacagc gaggccaccc tggaagtcgt ggtgaaaggc atcgtgttcc      840

attacagagc catctctaca cgctacaccc tcgactttga cagggcgcag cgggcctgcc      900

tgcagaacag tgccatcatt gccacgcctg agcagctgca ggccgcctac gaagacggct      960

tccaccagtg tgacgccggc tggctggctg accagactgt cagatacccc atccacactc     1020

cccgggaagg ctgctatgga gacaaggatg agtttcctgg tgtgaggacg tatggcatcc     1080

gagacaccaa cgagacctat gatgtgtact gcttcgccga ggagatggag ggtgaggtct     1140

tttatgcaac atctccagag aagttcacct tccaggaagc agccaatgag tgccggcggc     1200

tgggtgcccg gctggccacc acgggccagc tctacctggc ctggcaggct ggcatggaca     1260

tgtgcagcgc cggctggctg gccgaccgca gcgtgcgcta ccccatctcc aaggcccggc     1320

ccaactgcgg tggcaacctc ctgggcgtga ggaccgtcta cgtgcatgcc aaccagacgg     1380

gctaccccga cccctcatcc cgctacgacg ccatctgcta cacaggtgaa gactttgtgg     1440

acatcccaga aaacttcttt ggagtggggg gtgaggagga catcaccgtc cagacagtga     1500

cctggcctga catggagctg ccactgcctc gaaacatcac tgagggtgaa gcccgaggca     1560

gcgtgatcct taccgtaaag cccatcttcg aggtctcccc cagtcccctg gaacccgagg     1620

agcccttcac gtttgcccct gaaatagggg ccactgcctt cgctgaggtt gagaatgaga     1680

ctggagaggc caccaggccc tggggctttc ccacacctgg cctgggccct gccacggcat     1740

tcaccagtga ggacctcgtc gtgcaggtga ccgctgtccc tgggcagccg catttgccag     1800

ggggggtcgt cttccactac cgcccgggac ccacccgcta ctcgctgacc tttgaggagg     1860

cacagcaggc ctgcctgcgc acgggggcgg tcattgcctc gccggagcag ctccaggccg     1920

cctacgaagc aggctatgag cagtgtgacg ccggctggct gcgggaccag accgtcagat     1980

accccattgt gagcccccgg accccatgcg tgggtgacaa ggacagcagc ccaggggtca     2040

ggacctatgg cgtgcgccca tcaacagaga cctacgatgt ctactgcttt gtagacagac     2100

ttgaggggga ggtgttcttc gccacacgcc ttgagcagtt caccttccag gaagcactgg     2160

agttctgtga atctcacaat gctacgctgg ccaccacggg ccagctctac gccgcctgga     2220

gccgcggcct ggacaagtgc tatgccggct ggctggccga cggcagcctc cgctacccca     2280

tcgtcacccc aaggcctgcc tgcggtgggg acaagccagg cgtgagaacg gtctacctct     2340

accctaacca gacgggcctc ccagacccac tgtcccggca ccatgccttc tgcttccgag     2400

gcatttcagc ggttccttct ccaggagaag aagagggtgg cacacccaca tcaccctctg     2460

gtgtggagga gtggatcgtg acccaagtgg ttcctggtgt ggctgctgtc cccgtagaag     2520

aggagacaac tgctgtaccc tcaggggaga ctactgccat cctagagttc accaccgagc     2580

cagaaaacca gacagaatgg gaaccagcct ataccccagt gggcacatcc ccgctgccag     2640

ggatccttcc tacttggcct cccactggcg cagcaacaga ggaaagtaca gaaggccctt     2700

ctgcaactga agtgccctct gcctcagagg aaccatcccc ctcagaggtg ccattcccct     2760

cagaggagcc atccccctca gaggaaccat tcccctcagt gaggccattc ccctcagtgg     2820

agctgttccc ctcagaggag ccattcccct ccaaggagcc atccccctca gaggaaccat     2880

cagcctcgga agagccgtat acaccttcac cccccgtgcc cagctggact gagctgccca     2940

gctctgggga ggaatctggg gcccctgatg tcagtggtga cttcacaggc agtggagatg     3000

tttcaggaca ccttgacttc agtgggcagc tgtcagggga cagggcaagt ggactgccct     3060

ctggagacct ggactccagt ggtcttactt ccacagtggg ctcaggcctg cctgtggaaa     3120

gtggactacc ctcaggggat gaagagagaa ttgagtggcc cagcactcct acggttggtg     3180

aactgccctc tggagctgag atcctagagg gctctgcctc tggagttggg gatctcagtg     3240

gacttccttc tggagaagtt ctagagacct ctgcctctgg agtaggagac ctcagtgggc     3300

ttccttctgg agaagttcta gagaccactg cccctggagt agaggacatc agcgggcttc     3360

cttctggaga agttctagag accactgccc ctggagtaga ggacatcagc gggcttcctt     3420

ctggagaagt tctagagacc actgcccctg gagtagagga catcagcggg cttccttctg     3480

gagaagttct agagaccact gcccctggag tagaggacat cagcgggctt ccttctggag     3540

aagttctaga gaccactgcc cctggagtag aggacatcag cgggcttcct tctggagaag     3600

ttctagagac cactgcccct ggagtagagg acatcagcgg gcttccttct ggagaagttc     3660

tagagaccgc tgcccctgga gtagaggaca tcagcgggct tccttctgga gaagttctag     3720

agaccgctgc ccctggagta gaggacatca gcgggcttcc ttctggagaa gttctagaga     3780

ccgctgcccc tggagtagag gacatcagcg ggcttccttc tggagaagtt ctagagaccg     3840

ctgcccctgg agtagaggac atcagcgggc ttccttctgg agaagttcta gagaccgctg     3900

cccctggagt agaggacatc agcgggcttc cttctggaga agttctagag accgctgccc     3960

ctggagtaga ggacatcagc gggcttcctt ctggagaagt tctagagacc gctgcccctg     4020

gagtagagga catcagcggg cttccttctg gagaagttct agagactgct gcccctggag     4080

tagaggacat cagcgggctt ccttctggag aagttctaga gactgctgcc cctggagtag     4140

aggacatcag cgggcttcct tctggagaag ttctagagac tgctgcccct ggagtagagg     4200

acatcagcgg gcttccttct ggagaagttc tagagactgc tgcccctgga gtagaggaca     4260

tcagcgggct tccttctgga gaagttctag agactgctgc ccctggagta gaggacatca     4320

gcgggcttcc ttctggagaa gttctagaga ctgctgcccc tggagtagag gacatcagcg     4380

ggcttccttc tggagaagtt ctagagactg ctgcccctgg agtagaggac atcagcgggc     4440

ttccttctgg agaagttcta gagactgctg cccctggagt agaggacatc agcgggcttc     4500

cttctggaga agttctagag actgctgccc ctggagtaga ggacatcagc gggcttcctt     4560

ctggagaagt tctagagact actgcccctg gagtagagga gatcagcggg cttccttctg     4620

gagaagttct agagactact gcccctggag tagatgagat cagtgggctt ccttctggag     4680

aagttctaga gactactgcc cctggagtag aggagatcag cgggcttcct tctggagaag     4740

ttctagagac ttctacctct gcggtagggg acctcagtgg acttccttct ggaggagaag     4800

ttctagagat ttctgtctct ggagtagagg acatcagtgg gcttccttct ggagaggttg     4860

tagagacttc tgcctctgga atagaggatg tcagtgaact tccttcagga gaaggtctag     4920

agacctctgc ttctggagta gaggacctca gcaggctccc ttctggagaa gaagttctag     4980

agatttctgc ctctggattt ggggacctca gtggacttcc ttctggagga gaaggtctag     5040

agacctctgc ttctgaagta gggactgacc tcagtgggct tccttctgga agggagggtc     5100

tagagacttc agcttctgga gctgaggacc tcagtgggtt gccttctgga aaagaagact     5160

tggtggggtc agcttctgga gacttggact tgggcaaact gccttctgga actctaggaa     5220

gtgggcaagc tccagaaaca agtggtcttc cctctggatt tagtggtgag tattctgggg     5280

tggaccttgg aagtggccca ccctctggcc tgcctgactt tagtggactt ccatctggat     5340

tcccaactgt ttccctagtg gattctacat tggtggaagt ggtcacagcc tccactgcaa     5400

gtgaactgga agggagggga accattggca tcagtggtgc aggagaaata tctggactgc     5460

cctccagtga gctggacatt agtgggagag ctagtggact cccttcagga actgaactca     5520

gtggccaagc atctgggtct cctgatgtca gtggggaaat acctggactc tttggtgtca     5580

gtggacagcc atcagggttt cctgacacta gtggggaaac atctggagtg actgagctta     5640

gcgggctgtc ctctggacaa ccaggtatta gtggagaagc atctggagtt ctttatggca     5700

ctagtcaacc ctttggcata actgatctga gtggagaaac atctggggtc cctgatctca     5760

gtgggcagcc ttcagggtta ccagggttca gtggggcaac atcaggagtc cctgacctgg     5820

tttctggtac cacgagtggc agcggtgaat cttctgggat tacatttgtg gacaccagtt     5880

tggttgaagt ggcccctact acatttaaag aagaagaagg cttagggtct gtggaactca     5940

gtggcctccc ttccggagag gcagatctgt caggcaaatc tgggatggtg gatgtcagtg     6000

gacagttttc tggaacagtc gattccagtg ggtttacatc ccagactccg gaattcagtg     6060

gcctaccaag tggcatagct gaggtcagtg gagaatcctc cagagctgag attgggagca     6120

gcctgccctc gggagcatat tatggcagtg gaactccatc tagtttcccc actgtctctc     6180

ttgtagacag aactttggtg gaatctgtaa cccaggctcc aacagcccaa gaggcaggag     6240

aagggccttc tggcatttta gaactcagtg gtgctcattc tggagcacca gacatgtctg     6300

gggagcattc tggatttctg gacctaagtg ggctgcagtc cgggctgata gagcccagcg     6360

gagagccacc aggtactcca tattttagtg gggattttgc cagcaccacc aatgtaagtg     6420

gagaatcctc tgtagccatg ggcaccagtg gagaggcctc aggacttcca gaagttactt     6480

taatcacttc tgagttcgtg gagggtgtta ctgaaccaac tatttctcag gaactaggcc     6540

aaaggccccc tgtgacacac acaccccagc tttttgagtc cagtggaaaa gtctccacag     6600

ctggggacat tagtggagct accccagtgc tccctgggtc tggagtagaa gtatcatcag     6660

tcccagaatc tagcagtgag acgtccgcct atcctgaagc tgggttcggg gcatctgccg     6720

cccctgaggc cagcagagaa gattctgggt cccctgatct gagtgaaacc acctctgcat     6780

tccacgaagc taaccttgag agatcctctg gcctaggagt gagcggcagc actttgacat     6840

ttcaagaagg cgaggcgtcc gctgccccag aagtgagtgg agaatccacc accaccagtg     6900

atgtggggac agaggcacca ggcttgcctt cagccactcc cacggcttct ggagacagga     6960

ctgaaatcag cggagacctg tctggtcaca cctcgcagct gggcgttgtc atcagcacca     7020

gcatcccaga gtctgagtgg acccagcaga cccagcgccc tgcagagacg catctagaaa     7080

ttgagtcctc aagcctcctg tactcaggag aagagactca cacagtcgaa acagccacct     7140

ccccaacaga tgcttccatc ccagcttctc cggaatggaa acgtgaatca gaatcaactg     7200

ctgcagcccc cgccaggtcc tgtgcagagg agccctgtgg agctgggacc tgcaaggaga     7260

cagagggaca cgtcatatgc ctgtgccccc ctggctacac tggcgagcac tgtaacatag     7320

accaggaggt atgtgaggag ggctggaaca agtaccaggg ccactgttac cgccacttcc     7380

cggaccgcga gacctgggtg gatgctgagc gccggtgtcg ggagcagcag tcacacctga     7440

gcagcatcgt cacccccgag gagcaggagt ttgtcaacaa caatgcccaa gactaccagt     7500

ggatcggcct gaacgacagg accatcgaag gggacttccg ctggtcagat ggacacccca     7560

tgcaatttga gaactggcgc cccaaccagc ctgacaactt ttttgccgct ggagaggact     7620

gtgtggtgat gatctggcac gagaagggcg agtggaatga tgttccctgc aattaccacc     7680

tccccttcac gtgtaaaaag ggcacagtgg cctgcggaga gccccctgtg gtggagcatg     7740

ccaggacctt cgggcagaag aaggaccggt atgagatcaa ttccctggtg cggtaccagt     7800

gcacagaggg gtttgtccag cgccacatgc ccaccatccg gtgccagccc agcgggcact     7860

gggaggagcc tcagatcacc tgcacagacc ccaccaccta caaacgcaga ctacagaagc     7920

ggagctcacg gcaccctcgg aggagccgcc ccagcacagc ccactgagaa gagcttccag     7980

gacgcaccca ggacgctgag cccaggagcc tgccaggctg acgtgcatcc cacccagacg     8040

gtgtcctctt cttgtcgctt tttgtcatat aaggaatccc attaaagaag gaaaaaaata     8100

aatcccacat ttgtgtatgc acccactcac ccctccaaat cagcaaaacc gcatctaatt     8160

tgtccgccga atgccaaagc aaagcaaact tattataacc cttggactga gtttagagac     8220

atttcttcaa tttcccatcg tgcctttcca gggaccagtg cagggacagg gggagaaggg     8280

gaggggttaa gttaaataaa gaagattatt tttgtttcct gactttatcc aagagcagtg     8340

caatcgttgg ttatttcacc tccagggaga gctagggagg agggaggagg gctccaaagg     8400

agctggaagg agcagaggcc tgagagcagg aagaactcgg aaccgcagct gaatgtattg     8460

gatgagaagg agccaggagg gctacaccat ctgtatgagg gaaaagcctt gggggagagg     8520

ggtgggttcc tgcctcctgc cgagggtaag ccggcaggag agagccatca gagggacctc     8580

cgctgcctgg gagttgggtt ccctccaagg gtccctcttt cagtgtcctc tctctcacct     8640

gggtctgcca ccctaacagg tggcaactcg gcagggctgc tgggggcact tcctgcccag     8700

tggggggtgc cgcccaacct tctcccctcc ccacccccgc ccccgggacc gtgcaggcac     8760

cagggttccg tgcacctatt tatatttttg aaaactgaag attataatat tataataata     8820

ataaagacat tggaagagat                                                 8840


<210> 3
<211> 8960
<212> DNA
<213> Homo sapiens


<220> 
<223> NM_001369268.1 aggrecan core protein isoform 3 precursor

<400> 3
gcccgcccac ctacctcccc gccgctccag agggggctcg cagagctgag gacgcgcgca       60

gcgctgctca aggtctctct ctctcagcac cctcgccggc cggcgtctga cgcgggtgcc      120

agggtctccg ggcacctttc agtgtccatt ccctcagcca gccaggactc cgcaacccag      180

cagttgccgc tgcggccaca gcccgagggg acctgcggac aggacgccgg caggaggagg      240

ggtgcgcagc gcccgcgcag agcgtctccc tcgctacgca gcgagacccg ggcctcccgg      300

ccccaggagc ccccagctgc ctcgccaggt gtgtgggact gaagttcttg gagaagggag      360

tccaactctt caaggtgaac tatgaccact ttactctggg ttttcgtgac tctgagggtc      420

atcactgcag ctgtcactgt agaaacttca gaccatgaca actcgctgag tgtcagcatc      480

ccccaaccgt ccccgctgag ggtcctcctg gggacctccc tcaccatccc ctgctatttc      540

atcgacccca tgcaccctgt gaccaccgcc ccttctaccg ccccactggc cccaagaatc      600

aagtggagcc gtgtgtccaa ggagaaggag gtagtgctgc tggtggccac tgaagggcgc      660

gtgcgggtca acagtgccta tcaggacaag gtctcactgc ccaactaccc ggccatcccc      720

agtgacgcca ccttggaagt ccagagcctg cgctccaatg actctggggt ctaccgctgc      780

gaggtgatgc atggcatcga ggacagcgag gccaccctgg aagtcgtggt gaaaggcatc      840

gtgttccatt acagagccat ctctacacgc tacaccctcg actttgacag ggcgcagcgg      900

gcctgcctgc agaacagtgc catcattgcc acgcctgagc agctgcaggc cgcctacgaa      960

gacggcttcc accagtgtga cgccggctgg ctggctgacc agactgtcag ataccccatc     1020

cacactcccc gggaaggctg ctatggagac aaggatgagt ttcctggtgt gaggacgtat     1080

ggcatccgag acaccaacga gacctatgat gtgtactgct tcgccgagga gatggagggt     1140

gaggtctttt atgcaacatc tccagagaag ttcaccttcc aggaagcagc caatgagtgc     1200

cggcggctgg gtgcccggct ggccaccacg ggccagctct acctggcctg gcaggctggc     1260

atggacatgt gcagcgccgg ctggctggcc gaccgcagcg tgcgctaccc catctccaag     1320

gcccggccca actgcggtgg caacctcctg ggcgtgagga ccgtctacgt gcatgccaac     1380

cagacgggct accccgaccc ctcatcccgc tacgacgcca tctgctacac aggtgaagac     1440

tttgtggaca tcccagaaaa cttctttgga gtggggggtg aggaggacat caccgtccag     1500

acagtgacct ggcctgacat ggagctgcca ctgcctcgaa acatcactga gggtgaagcc     1560

cgaggcagcg tgatccttac cgtaaagccc atcttcgagg tctcccccag tcccctggaa     1620

cccgaggagc ccttcacgtt tgcccctgaa ataggggcca ctgccttcgc tgaggttgag     1680

aatgagactg gagaggccac caggccctgg ggctttccca cacctggcct gggccctgcc     1740

acggcattca ccagtgagga cctcgtcgtg caggtgaccg ctgtccctgg gcagccgcat     1800

ttgccagggg gggtcgtctt ccactaccgc ccgggaccca cccgctactc gctgaccttt     1860

gaggaggcac agcaggcctg cctgcgcacg ggggcggtca ttgcctcgcc ggagcagctc     1920

caggccgcct acgaagcagg ctatgagcag tgtgacgccg gctggctgcg ggaccagacc     1980

gtcagatacc ccattgtgag cccccggacc ccatgcgtgg gtgacaagga cagcagccca     2040

ggggtcagga cctatggcgt gcgcccatca acagagacct acgatgtcta ctgctttgta     2100

gacagacttg agggggaggt gttcttcgcc acacgccttg agcagttcac cttccaggaa     2160

gcactggagt tctgtgaatc tcacaatgct acgctggcca ccacgggcca gctctacgcc     2220

gcctggagcc gcggcctgga caagtgctat gccggctggc tggccgacgg cagcctccgc     2280

taccccatcg tcaccccaag gcctgcctgc ggtggggaca agccaggcgt gagaacggtc     2340

tacctctacc ctaaccagac gggcctccca gacccactgt cccggcacca tgccttctgc     2400

ttccgaggca tttcagcggt tccttctcca ggagaagaag agggtggcac acccacatca     2460

ccctctggtg tggaggagtg gatcgtgacc caagtggttc ctggtgtggc tgctgtcccc     2520

gtagaagagg agacaactgc tgtaccctca ggggagacta ctgccatcct agagttcacc     2580

accgagccag aaaaccagac agaatgggaa ccagcctata ccccagtggg cacatccccg     2640

ctgccaggga tccttcctac ttggcctccc actggcgcag caacagagga aagtacagaa     2700

ggcccttctg caactgaagt gccctctgcc tcagaggaac catccccctc agaggtgcca     2760

ttcccctcag aggagccatc cccctcagag gaaccattcc cctcagtgag gccattcccc     2820

tcagtggagc tgttcccctc agaggagcca ttcccctcca aggagccatc cccctcagag     2880

gaaccatcag cctcggaaga gccgtataca ccttcacccc ccgtgcccag ctggactgag     2940

ctgcccagct ctggggagga atctggggcc cctgatgtca gtggtgactt cacaggcagt     3000

ggagatgttt caggacacct tgacttcagt gggcagctgt caggggacag ggcaagtgga     3060

ctgccctctg gagacctgga ctccagtggt cttacttcca cagtgggctc aggcctgcct     3120

gtggaaagtg gactaccctc aggggatgaa gagagaattg agtggcccag cactcctacg     3180

gttggtgaac tgccctctgg agctgagatc ctagagggct ctgcctctgg agttggggat     3240

ctcagtggac ttccttctgg agaagttcta gagacctctg cctctggagt aggagacctc     3300

agtgggcttc cttctggaga agttctagag accactgccc ctggagtaga ggacatcagc     3360

gggcttcctt ctggagaagt tctagagacc actgcccctg gagtagagga catcagcggg     3420

cttccttctg gagaagttct agagaccact gcccctggag tagaggacat cagcgggctt     3480

ccttctggag aagttctaga gaccactgcc cctggagtag aggacatcag cgggcttcct     3540

tctggagaag ttctagagac cactgcccct ggagtagagg acatcagcgg gcttccttct     3600

ggagaagttc tagagaccac tgcccctgga gtagaggaca tcagcgggct tccttctgga     3660

gaagttctag agaccgctgc ccctggagta gaggacatca gcgggcttcc ttctggagaa     3720

gttctagaga ccgctgcccc tggagtagag gacatcagcg ggcttccttc tggagaagtt     3780

ctagagaccg ctgcccctgg agtagaggac atcagcgggc ttccttctgg agaagttcta     3840

gagaccgctg cccctggagt agaggacatc agcgggcttc cttctggaga agttctagag     3900

accgctgccc ctggagtaga ggacatcagc gggcttcctt ctggagaagt tctagagacc     3960

gctgcccctg gagtagagga catcagcggg cttccttctg gagaagttct agagaccgct     4020

gcccctggag tagaggacat cagcgggctt ccttctggag aagttctaga gactgctgcc     4080

cctggagtag aggacatcag cgggcttcct tctggagaag ttctagagac tgctgcccct     4140

ggagtagagg acatcagcgg gcttccttct ggagaagttc tagagactgc tgcccctgga     4200

gtagaggaca tcagcgggct tccttctgga gaagttctag agactgctgc ccctggagta     4260

gaggacatca gcgggcttcc ttctggagaa gttctagaga ctgctgcccc tggagtagag     4320

gacatcagcg ggcttccttc tggagaagtt ctagagactg ctgcccctgg agtagaggac     4380

atcagcgggc ttccttctgg agaagttcta gagactgctg cccctggagt agaggacatc     4440

agcgggcttc cttctggaga agttctagag actgctgccc ctggagtaga ggacatcagc     4500

gggcttcctt ctggagaagt tctagagact gctgcccctg gagtagagga catcagcggg     4560

cttccttctg gagaagttct agagactact gcccctggag tagaggagat cagcgggctt     4620

ccttctggag aagttctaga gactactgcc cctggagtag atgagatcag tgggcttcct     4680

tctggagaag ttctagagac tactgcccct ggagtagagg agatcagcgg gcttccttct     4740

ggagaagttc tagagacttc tacctctgcg gtaggggacc tcagtggact tccttctgga     4800

ggagaagttc tagagatttc tgtctctgga gtagaggaca tcagtgggct tccttctgga     4860

gaggttgtag agacttctgc ctctggaata gaggatgtca gtgaacttcc ttcaggagaa     4920

ggtctagaga cctctgcttc tggagtagag gacctcagca ggctcccttc tggagaagaa     4980

gttctagaga tttctgcctc tggatttggg gacctcagtg gacttccttc tggaggagaa     5040

ggtctagaga cctctgcttc tgaagtaggg actgacctca gtgggcttcc ttctggaagg     5100

gagggtctag agacttcagc ttctggagct gaggacctca gtgggttgcc ttctggaaaa     5160

gaagacttgg tggggtcagc ttctggagac ttggacttgg gcaaactgcc ttctggaact     5220

ctaggaagtg ggcaagctcc agaaacaagt ggtcttccct ctggatttag tggtgagtat     5280

tctggggtgg accttggaag tggcccaccc tctggcctgc ctgactttag tggacttcca     5340

tctggattcc caactgtttc cctagtggat tctacattgg tggaagtggt cacagcctcc     5400

actgcaagtg aactggaagg gaggggaacc attggcatca gtggtgcagg agaaatatct     5460

ggactgccct ccagtgagct ggacattagt gggagagcta gtggactccc ttcaggaact     5520

gaactcagtg gccaagcatc tgggtctcct gatgtcagtg gggaaatacc tggactcttt     5580

ggtgtcagtg gacagccatc agggtttcct gacactagtg gggaaacatc tggagtgact     5640

gagcttagcg ggctgtcctc tggacaacca ggtattagtg gagaagcatc tggagttctt     5700

tatggcacta gtcaaccctt tggcataact gatctgagtg gagaaacatc tggggtccct     5760

gatctcagtg ggcagccttc agggttacca gggttcagtg gggcaacatc aggagtccct     5820

gacctggttt ctggtaccac gagtggcagc ggtgaatctt ctgggattac atttgtggac     5880

accagtttgg ttgaagtggc ccctactaca tttaaagaag aagaaggctt agggtctgtg     5940

gaactcagtg gcctcccttc cggagaggca gatctgtcag gcaaatctgg gatggtggat     6000

gtcagtggac agttttctgg aacagtcgat tccagtgggt ttacatccca gactccggaa     6060

ttcagtggcc taccaagtgg catagctgag gtcagtggag aatcctccag agctgagatt     6120

gggagcagcc tgccctcggg agcatattat ggcagtggaa ctccatctag tttccccact     6180

gtctctcttg tagacagaac tttggtggaa tctgtaaccc aggctccaac agcccaagag     6240

gcaggagaag ggccttctgg cattttagaa ctcagtggtg ctcattctgg agcaccagac     6300

atgtctgggg agcattctgg atttctggac ctaagtgggc tgcagtccgg gctgatagag     6360

cccagcggag agccaccagg tactccatat tttagtgggg attttgccag caccaccaat     6420

gtaagtggag aatcctctgt agccatgggc accagtggag aggcctcagg acttccagaa     6480

gttactttaa tcacttctga gttcgtggag ggtgttactg aaccaactat ttctcaggaa     6540

ctaggccaaa ggccccctgt gacacacaca ccccagcttt ttgagtccag tggaaaagtc     6600

tccacagctg gggacattag tggagctacc ccagtgctcc ctgggtctgg agtagaagta     6660

tcatcagtcc cagaatctag cagtgagacg tccgcctatc ctgaagctgg gttcggggca     6720

tctgccgccc ctgaggccag cagagaagat tctgggtccc ctgatctgag tgaaaccacc     6780

tctgcattcc acgaagctaa ccttgagaga tcctctggcc taggagtgag cggcagcact     6840

ttgacatttc aagaaggcga ggcgtccgct gccccagaag tgagtggaga atccaccacc     6900

accagtgatg tggggacaga ggcaccaggc ttgccttcag ccactcccac ggcttctgga     6960

gacaggactg aaatcagcgg agacctgtct ggtcacacct cgcagctggg cgttgtcatc     7020

agcaccagca tcccagagtc tgagtggacc cagcagaccc agcgccctgc agagacgcat     7080

ctagaaattg agtcctcaag cctcctgtac tcaggagaag agactcacac agtcgaaaca     7140

gccacctccc caacagatgc ttccatccca gcttctccgg aatggaaacg tgaatcagaa     7200

tcaactgctg cagcccccgc caggtcctgt gcagaggagc cctgtggagc tgggacctgc     7260

aaggagacag agggacacgt catatgcctg tgcccccctg gctacactgg cgagcactgt     7320

aacatagaca ttgatgagtg cctctcaagc ccttgtctga atggagccac ctgcgtggat     7380

gccatcgact ctttcacatg cttatgcctt cccagctacg aaggggacct gtgtgagatt     7440

gaccaggagg tatgtgagga gggctggaac aagtaccagg gccactgtta ccgccacttc     7500

ccggaccgcg agacctgggt ggatgctgag cgccggtgtc gggagcagca gtcacacctg     7560

agcagcatcg tcacccccga ggagcaggag tttgtcaaca acaatgccca agactaccag     7620

tggatcggcc tgaacgacag gaccatcgaa ggggacttcc gctggtcaga tggacacccc     7680

atgcaatttg agaactggcg ccccaaccag cctgacaact tttttgccgc tggagaggac     7740

tgtgtggtga tgatctggca cgagaagggc gagtggaatg atgttccctg caattaccac     7800

ctccccttca cgtgtaaaaa gggcacagtg gcctgcggag agccccctgt ggtggagcat     7860

gccaggacct tcgggcagaa gaaggaccgg tatgagatca attccctggt gcggtaccag     7920

tgcacagagg ggtttgtcca gcgccacatg cccaccatcc ggtgccagcc cagcgggcac     7980

tgggaggagc ctcagatcac ctgcacagac cccaccacct acaaacgcag actacagaag     8040

cggagctcac ggcaccctcg gaggagccgc cccagcacag cccactgaga agagcttcca     8100

ggacgcaccc aggacgctga gcccaggagc ctgccaggct gacgtgcatc ccacccagac     8160

ggtgtcctct tcttgtcgct ttttgtcata taaggaatcc cattaaagaa ggaaaaaaat     8220

aaatcccaca tttgtgtatg cacccactca cccctccaaa tcagcaaaac cgcatctaat     8280

ttgtccgccg aatgccaaag caaagcaaac ttattataac ccttggactg agtttagaga     8340

catttcttca atttcccatc gtgcctttcc agggaccagt gcagggacag ggggagaagg     8400

ggaggggtta agttaaataa agaagattat ttttgtttcc tgactttatc caagagcagt     8460

gcaatcgttg gttatttcac ctccagggag agctagggag gagggaggag ggctccaaag     8520

gagctggaag gagcagaggc ctgagagcag gaagaactcg gaaccgcagc tgaatgtatt     8580

ggatgagaag gagccaggag ggctacacca tctgtatgag ggaaaagcct tgggggagag     8640

gggtgggttc ctgcctcctg ccgagggtaa gccggcagga gagagccatc agagggacct     8700

ccgctgcctg ggagttgggt tccctccaag ggtccctctt tcagtgtcct ctctctcacc     8760

tgggtctgcc accctaacag gtggcaactc ggcagggctg ctgggggcac ttcctgccca     8820

gtggggggtg ccgcccaacc ttctcccctc cccacccccg cccccgggac cgtgcaggca     8880

ccagggttcc gtgcacctat ttatattttt gaaaactgaa gattataata ttataataat     8940

aataaagaca ttggaagaga                                                 8960


