                         SEQUENCE LISTING

<110>  Pairwise Plants Services, Inc.
       Nie, Jingyi
       Hummel, Aaron
       Lawit, Shai Joshua
 
<120>  RECRUITMENT OF DNA POLYMERASE FOR TEMPLATED EDITING

<130>  1499.14.WO

<150>  US 62/957,542
<151>  2020-01-06

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  1228
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  1

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  2
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp.

<400>  2

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  3
<211>  1241
<212>  PRT
<213>  Utyrivibrio proteoclasticus

<400>  3

Met Leu Leu Tyr Glu Asn Tyr Thr Lys Arg Asn Gln Ile Thr Lys Ser 
1               5                   10                  15      


Leu Arg Leu Glu Leu Arg Pro Gln Gly Lys Thr Leu Arg Asn Ile Lys 
            20                  25                  30          


Glu Leu Asn Leu Leu Glu Gln Asp Lys Ala Ile Tyr Ala Leu Leu Glu 
        35                  40                  45              


Arg Leu Lys Pro Val Ile Asp Glu Gly Ile Lys Asp Ile Ala Arg Asp 
    50                  55                  60                  


Thr Leu Lys Asn Cys Glu Leu Ser Phe Glu Lys Leu Tyr Glu His Phe 
65                  70                  75                  80  


Leu Ser Gly Asp Lys Lys Ala Tyr Ala Lys Glu Ser Glu Arg Leu Lys 
                85                  90                  95      


Lys Glu Ile Val Lys Thr Leu Ile Lys Asn Leu Pro Glu Gly Ile Gly 
            100                 105                 110         


Lys Ile Ser Glu Ile Asn Ser Ala Lys Tyr Leu Asn Gly Val Leu Tyr 
        115                 120                 125             


Asp Phe Ile Asp Lys Thr His Lys Asp Ser Glu Glu Lys Gln Asn Ile 
    130                 135                 140                 


Leu Ser Asp Ile Leu Glu Thr Lys Gly Tyr Leu Ala Leu Phe Ser Lys 
145                 150                 155                 160 


Phe Leu Thr Ser Arg Ile Thr Thr Leu Glu Gln Ser Met Pro Lys Arg 
                165                 170                 175     


Val Ile Glu Asn Phe Glu Ile Tyr Ala Ala Asn Ile Pro Lys Met Gln 
            180                 185                 190         


Asp Ala Leu Glu Arg Gly Ala Val Ser Phe Ala Ile Glu Tyr Glu Ser 
        195                 200                 205             


Ile Cys Ser Val Asp Tyr Tyr Asn Gln Ile Leu Ser Gln Glu Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Arg Leu Ile Ser Gly Ile Met Asp Glu Asp Gly Ala 
225                 230                 235                 240 


Lys Glu Lys Gly Ile Asn Gln Thr Ile Ser Glu Lys Asn Ile Lys Ile 
                245                 250                 255     


Lys Ser Glu His Leu Glu Glu Lys Pro Phe Arg Ile Leu Lys Gln Leu 
            260                 265                 270         


His Lys Gln Ile Leu Glu Glu Arg Glu Lys Ala Phe Thr Ile Asp His 
        275                 280                 285             


Ile Asp Ser Asp Glu Glu Val Val Gln Val Thr Lys Glu Ala Phe Glu 
    290                 295                 300                 


Gln Thr Lys Glu Gln Trp Glu Asn Ile Lys Lys Ile Asn Gly Phe Tyr 
305                 310                 315                 320 


Ala Lys Asp Pro Gly Asp Ile Thr Leu Phe Ile Val Val Gly Pro Asn 
                325                 330                 335     


Gln Thr His Val Leu Ser Gln Leu Ile Tyr Gly Glu His Asp Arg Ile 
            340                 345                 350         


Arg Leu Leu Leu Glu Glu Tyr Glu Lys Asn Thr Leu Glu Val Leu Pro 
        355                 360                 365             


Arg Arg Thr Lys Ser Glu Asp Ala Arg Tyr Asp Lys Phe Val Asn Ala 
    370                 375                 380                 


Val Pro Lys Lys Val Ala Lys Glu Ser His Thr Phe Asp Gly Leu Gln 
385                 390                 395                 400 


Lys Met Thr Gly Asp Asp Arg Leu Phe Ile Leu Tyr Arg Asp Glu Leu 
                405                 410                 415     


Ala Arg Asn Tyr Met Arg Ile Lys Glu Ala Tyr Gly Thr Phe Glu Arg 
            420                 425                 430         


Asp Ile Leu Lys Ser Arg Arg Gly Ile Lys Gly Asn Arg Asp Val Gln 
        435                 440                 445             


Glu Ser Leu Val Ser Phe Tyr Asp Glu Leu Thr Lys Phe Arg Ser Ala 
    450                 455                 460                 


Leu Arg Ile Ile Asn Ser Gly Asn Asp Glu Lys Ala Asp Pro Ile Phe 
465                 470                 475                 480 


Tyr Asn Thr Phe Asp Gly Ile Phe Glu Lys Ala Asn Arg Thr Tyr Lys 
                485                 490                 495     


Ala Glu Asn Leu Cys Arg Asn Tyr Val Thr Lys Ser Pro Ala Asp Asp 
            500                 505                 510         


Ala Arg Ile Met Ala Ser Cys Leu Gly Thr Pro Ala Arg Leu Arg Thr 
        515                 520                 525             


His Trp Trp Asn Gly Glu Glu Asn Phe Ala Ile Asn Asp Val Ala Met 
    530                 535                 540                 


Ile Arg Arg Gly Asp Glu Tyr Tyr Tyr Phe Val Leu Thr Pro Asp Val 
545                 550                 555                 560 


Lys Pro Val Asp Leu Lys Thr Lys Asp Glu Thr Asp Ala Gln Ile Phe 
                565                 570                 575     


Val Gln Arg Lys Gly Ala Lys Ser Phe Leu Gly Leu Pro Lys Ala Leu 
            580                 585                 590         


Phe Lys Cys Ile Leu Glu Pro Tyr Phe Glu Ser Pro Glu His Lys Asn 
        595                 600                 605             


Asp Lys Asn Cys Val Ile Glu Glu Tyr Val Ser Lys Pro Leu Thr Ile 
    610                 615                 620                 


Asp Arg Arg Ala Tyr Asp Ile Phe Lys Asn Gly Thr Phe Lys Lys Thr 
625                 630                 635                 640 


Asn Ile Gly Ile Asp Gly Leu Thr Glu Glu Lys Phe Lys Asp Asp Cys 
                645                 650                 655     


Arg Tyr Leu Ile Asp Val Tyr Lys Glu Phe Ile Ala Val Tyr Thr Arg 
            660                 665                 670         


Tyr Ser Cys Phe Asn Met Ser Gly Leu Lys Arg Ala Asp Glu Tyr Asn 
        675                 680                 685             


Asp Ile Gly Glu Phe Phe Ser Asp Val Asp Thr Arg Leu Cys Thr Met 
    690                 695                 700                 


Glu Trp Ile Pro Val Ser Phe Glu Arg Ile Asn Asp Met Val Asp Lys 
705                 710                 715                 720 


Lys Glu Gly Leu Leu Phe Leu Val Arg Ser Met Phe Leu Tyr Asn Arg 
                725                 730                 735     


Pro Arg Lys Pro Tyr Glu Arg Thr Phe Ile Gln Leu Phe Ser Asp Ser 
            740                 745                 750         


Asn Met Glu His Thr Ser Met Leu Leu Asn Ser Arg Ala Met Ile Gln 
        755                 760                 765             


Tyr Arg Ala Ala Ser Leu Pro Arg Arg Val Thr His Lys Lys Gly Ser 
    770                 775                 780                 


Ile Leu Val Ala Leu Arg Asp Ser Asn Gly Glu His Ile Pro Met His 
785                 790                 795                 800 


Ile Arg Glu Ala Ile Tyr Lys Met Lys Asn Asn Phe Asp Ile Ser Ser 
                805                 810                 815     


Glu Asp Phe Ile Met Ala Lys Ala Tyr Leu Ala Glu His Asp Val Ala 
            820                 825                 830         


Ile Lys Lys Ala Asn Glu Asp Ile Ile Arg Asn Arg Arg Tyr Thr Glu 
        835                 840                 845             


Asp Lys Phe Phe Leu Ser Leu Ser Tyr Thr Lys Asn Ala Asp Ile Ser 
    850                 855                 860                 


Ala Arg Thr Leu Asp Tyr Ile Asn Asp Lys Val Glu Glu Asp Thr Gln 
865                 870                 875                 880 


Asp Ser Arg Met Ala Val Ile Val Thr Arg Asn Leu Lys Asp Leu Thr 
                885                 890                 895     


Tyr Val Ala Val Val Asp Glu Lys Asn Asn Val Leu Glu Glu Lys Ser 
            900                 905                 910         


Leu Asn Glu Ile Asp Gly Val Asn Tyr Arg Glu Leu Leu Lys Glu Arg 
        915                 920                 925             


Thr Lys Ile Lys Tyr His Asp Lys Thr Arg Leu Trp Gln Tyr Asp Val 
    930                 935                 940                 


Ser Ser Lys Gly Leu Lys Glu Ala Tyr Val Glu Leu Ala Val Thr Gln 
945                 950                 955                 960 


Ile Ser Lys Leu Ala Thr Lys Tyr Asn Ala Val Val Val Val Glu Ser 
                965                 970                 975     


Met Ser Ser Thr Phe Lys Asp Lys Phe Ser Phe Leu Asp Glu Gln Ile 
            980                 985                 990         


Phe Lys Ala Phe Glu Ala Arg Leu  Cys Ala Arg Met Ser  Asp Leu Ser 
        995                 1000                 1005             


Phe Asn  Thr Ile Lys Glu Gly  Glu Ala Gly Ser Ile  Ser Asn Pro 
    1010                 1015                 1020             


Ile Gln  Val Ser Asn Asn Asn  Gly Asn Ser Tyr Gln  Asp Gly Val 
    1025                 1030                 1035             


Ile Tyr  Phe Leu Asn Asn Ala  Tyr Thr Arg Thr Leu  Cys Pro Asp 
    1040                 1045                 1050             


Thr Gly  Phe Val Asp Val Phe  Asp Lys Thr Arg Leu  Ile Thr Met 
    1055                 1060                 1065             


Gln Ser  Lys Arg Gln Phe Phe  Ala Lys Met Lys Asp  Ile Arg Ile 
    1070                 1075                 1080             


Asp Asp  Gly Glu Met Leu Phe  Thr Phe Asn Leu Glu  Glu Tyr Pro 
    1085                 1090                 1095             


Thr Lys  Arg Leu Leu Asp Arg  Lys Glu Trp Thr Val  Lys Ile Ala 
    1100                 1105                 1110             


Gly Asp  Gly Ser Tyr Phe Asp  Lys Asp Lys Gly Glu  Tyr Val Tyr 
    1115                 1120                 1125             


Val Asn  Asp Ile Val Arg Glu  Gln Ile Ile Pro Ala  Leu Leu Glu 
    1130                 1135                 1140             


Asp Lys  Ala Val Phe Asp Gly  Asn Met Ala Glu Lys  Phe Leu Asp 
    1145                 1150                 1155             


Lys Thr  Ala Ile Ser Gly Lys  Ser Val Glu Leu Ile  Tyr Lys Trp 
    1160                 1165                 1170             


Phe Ala  Asn Ala Leu Tyr Gly  Ile Ile Thr Lys Lys  Asp Gly Glu 
    1175                 1180                 1185             


Lys Ile  Tyr Arg Ser Pro Ile  Thr Gly Thr Glu Ile  Asp Val Ser 
    1190                 1195                 1200             


Lys Asn  Thr Thr Tyr Asn Phe  Gly Lys Lys Phe Met  Phe Lys Gln 
    1205                 1210                 1215             


Glu Tyr  Arg Gly Asp Gly Asp  Phe Leu Asp Ala Phe  Leu Asn Tyr 
    1220                 1225                 1230             


Met Gln  Ala Gln Asp Ile Ala  Val 
    1235                 1240     


<210>  4
<211>  1238
<212>  PRT
<213>  Candidatus Methanoplasma termitum

<400>  4

Met Asn Asn Tyr Asp Glu Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Met Glu His Leu Glu 
            20                  25                  30          


Thr Phe Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Ala Ile Asp Glu Tyr His Lys Lys Phe Ile Asp Glu 
    50                  55                  60                  


His Leu Thr Asn Met Ser Leu Asp Trp Asn Ser Leu Lys Gln Ile Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Lys Ser Arg Glu Glu Lys Asp Lys Lys Val Phe Leu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Arg Gln Glu Ile Val Ser Glu Phe Lys Lys 
            100                 105                 110         


Asp Asp Arg Phe Lys Asp Leu Phe Ser Lys Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Lys Glu Glu Ile Tyr Lys Lys Gly Asn His Gln Glu Ile Asp Ala 
    130                 135                 140                 


Leu Lys Ser Phe Asp Lys Phe Ser Gly Tyr Phe Ile Gly Leu His Glu 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Asp Gly Asp Glu Ile Thr Ala Ile Ser 
                165                 170                 175     


Asn Arg Ile Val Asn Glu Asn Phe Pro Lys Phe Leu Asp Asn Leu Gln 
            180                 185                 190         


Lys Tyr Gln Glu Ala Arg Lys Lys Tyr Pro Glu Trp Ile Ile Lys Ala 
        195                 200                 205             


Glu Ser Ala Leu Val Ala His Asn Ile Lys Met Asp Ile Val Phe Ser 
    210                 215                 220                 


Leu Glu Tyr Phe Asn Lys Val Leu Asn Gln Glu Gly Ile Gln Arg Tyr 
225                 230                 235                 240 


Asn Leu Ala Leu Gly Gly Tyr Val Thr Lys Ser Gly Glu Lys Met Met 
                245                 250                 255     


Gly Leu Asn Asp Ala Leu Asn Leu Ala His Gln Ser Glu Lys Ser Ser 
            260                 265                 270         


Lys Gly Arg Ile His Met Thr Pro Leu Phe Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Glu Ser Phe Ser Tyr Ile Pro Asp Val Phe Thr Glu Asp Ser Gln 
    290                 295                 300                 


Leu Leu Pro Ser Ile Gly Gly Phe Phe Ala Gln Ile Glu Asn Asp Lys 
305                 310                 315                 320 


Asp Gly Asn Ile Phe Asp Arg Ala Leu Glu Leu Ile Ser Ser Tyr Ala 
                325                 330                 335     


Glu Tyr Asp Thr Glu Arg Ile Tyr Ile Arg Gln Ala Asp Ile Asn Arg 
            340                 345                 350         


Val Ser Asn Val Ile Phe Gly Glu Trp Gly Thr Leu Gly Gly Leu Met 
        355                 360                 365             


Arg Glu Tyr Lys Ala Asp Ser Ile Asn Asp Ile Asn Leu Glu Arg Thr 
    370                 375                 380                 


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Lys Glu Phe Ala Leu Ser 
385                 390                 395                 400 


Asp Val Leu Glu Ala Ile Asp Arg Thr Gly Asn Asn Asp Ala Phe Asn 
                405                 410                 415     


Glu Tyr Ile Ser Lys Met Arg Thr Ala Arg Glu Lys Ile Asp Ala Ala 
            420                 425                 430         


Arg Lys Glu Met Lys Phe Ile Ser Glu Lys Ile Ser Gly Asp Glu Glu 
        435                 440                 445             


Ser Ile His Ile Ile Lys Thr Leu Leu Asp Ser Val Gln Gln Phe Leu 
    450                 455                 460                 


His Phe Phe Asn Leu Phe Lys Ala Arg Gln Asp Ile Pro Leu Asp Gly 
465                 470                 475                 480 


Ala Phe Tyr Ala Glu Phe Asp Glu Val His Ser Lys Leu Phe Ala Ile 
                485                 490                 495     


Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Lys Asn Asn Leu 
            500                 505                 510         


Asn Thr Lys Lys Ile Lys Leu Asn Phe Lys Asn Pro Thr Leu Ala Asn 
        515                 520                 525             


Gly Trp Asp Gln Asn Lys Val Tyr Asp Tyr Ala Ser Leu Ile Phe Leu 
    530                 535                 540                 


Arg Asp Gly Asn Tyr Tyr Leu Gly Ile Ile Asn Pro Lys Arg Lys Lys 
545                 550                 555                 560 


Asn Ile Lys Phe Glu Gln Gly Ser Gly Asn Gly Pro Phe Tyr Arg Lys 
                565                 570                 575     


Met Val Tyr Lys Gln Ile Pro Gly Pro Asn Lys Asn Leu Arg Pro Val 
            580                 585                 590         


Phe Leu Thr Ser Thr Lys Gly Lys Lys Glu Tyr Lys Pro Ser Lys Glu 
        595                 600                 605             


Ile Ile Glu Gly Tyr Glu Ala Asp Lys His Ile Arg Gly Asp Lys Phe 
    610                 615                 620                 


Asp Leu Asp Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
625                 630                 635                 640 


Glu Lys His Lys Asp Trp Ser Lys Phe Asn Phe Tyr Phe Ser Pro Thr 
                645                 650                 655     


Glu Ser Tyr Gly Asp Ile Ser Glu Phe Tyr Leu Asp Val Glu Lys Gln 
            660                 665                 670         


Gly Tyr Arg Met His Phe Glu Asn Ile Ser Ala Glu Thr Ile Asp Glu 
        675                 680                 685             


Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
    690                 695                 700                 


Phe Val Lys Ala Ala Thr Gly Lys Lys Asp Met His Thr Ile Tyr Trp 
705                 710                 715                 720 


Asn Ala Ala Phe Ser Pro Glu Asn Leu Gln Asp Val Val Val Lys Leu 
                725                 730                 735     


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp Lys Ser Asp Ile Lys Glu 
            740                 745                 750         


Ile Val His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Asn Gly 
        755                 760                 765             


Arg Thr Pro Val Pro Asp Lys Ile His Lys Lys Leu Thr Asp Tyr His 
    770                 775                 780                 


Asn Gly Arg Thr Lys Asp Leu Gly Glu Ala Lys Glu Tyr Leu Asp Lys 
785                 790                 795                 800 


Val Arg Tyr Phe Lys Ala His Tyr Asp Ile Thr Lys Asp Arg Arg Tyr 
                805                 810                 815     


Leu Asn Asp Lys Ile Tyr Phe His Val Pro Leu Thr Leu Asn Phe Lys 
            820                 825                 830         


Ala Asn Gly Lys Lys Asn Leu Asn Lys Met Val Ile Glu Lys Phe Leu 
        835                 840                 845             


Ser Asp Glu Lys Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Ser Gly Lys Ile Ile Asp Gln 
865                 870                 875                 880 


Gln Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr Arg Glu Lys Leu Asn 
                885                 890                 895     


Gln Arg Glu Ile Glu Met Lys Asp Ala Arg Gln Ser Trp Asn Ala Ile 
            900                 905                 910         


Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Lys Ala Val His 
        915                 920                 925             


Glu Ile Thr Lys Met Ala Ile Gln Tyr Asn Ala Ile Val Val Met Glu 
    930                 935                 940                 


Glu Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Phe Glu Asn Met Leu Ile Asp Lys Met Asn Tyr Leu 
                965                 970                 975     


Val Phe Lys Asp Ala Pro Asp Glu Ser Pro Gly Gly Val Leu Asn Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Pro Leu Glu  Ser Phe Ala Lys Leu  Gly Lys Gln 
        995                 1000                 1005             


Thr Gly  Ile Leu Phe Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile 
    1010                 1015                 1020             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Thr  Ser Ser Lys 
    1025                 1030                 1035             


Thr Asn  Ala Gln Glu Arg Lys  Glu Phe Leu Gln Lys  Phe Glu Ser 
    1040                 1045                 1050             


Ile Ser  Tyr Ser Ala Lys Asp  Gly Gly Ile Phe Ala  Phe Ala Phe 
    1055                 1060                 1065             


Asp Tyr  Arg Lys Phe Gly Thr  Ser Lys Thr Asp His  Lys Asn Val 
    1070                 1075                 1080             


Trp Thr  Ala Tyr Thr Asn Gly  Glu Arg Met Arg Tyr  Ile Lys Glu 
    1085                 1090                 1095             


Lys Lys  Arg Asn Glu Leu Phe  Asp Pro Ser Lys Glu  Ile Lys Glu 
    1100                 1105                 1110             


Ala Leu  Thr Ser Ser Gly Ile  Lys Tyr Asp Gly Gly  Gln Asn Ile 
    1115                 1120                 1125             


Leu Pro  Asp Ile Leu Arg Ser  Asn Asn Asn Gly Leu  Ile Tyr Thr 
    1130                 1135                 1140             


Met Tyr  Ser Ser Phe Ile Ala  Ala Ile Gln Met Arg  Val Tyr Asp 
    1145                 1150                 1155             


Gly Lys  Glu Asp Tyr Ile Ile  Ser Pro Ile Lys Asn  Ser Lys Gly 
    1160                 1165                 1170             


Glu Phe  Phe Arg Thr Asp Pro  Lys Arg Arg Glu Leu  Pro Ile Asp 
    1175                 1180                 1185             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Arg  Gly Glu Leu 
    1190                 1195                 1200             


Thr Met  Arg Ala Ile Ala Glu  Lys Phe Asp Pro Asp  Ser Glu Lys 
    1205                 1210                 1215             


Met Ala  Lys Leu Glu Leu Lys  His Lys Asp Trp Phe  Glu Phe Met 
    1220                 1225                 1230             


Gln Thr  Arg Gly Asp 
    1235             


<210>  5
<211>  1281
<212>  PRT
<213>  Eubacterium eligens

<400>  5

Met Asn Gly Asn Arg Ser Ile Val Tyr Arg Glu Phe Val Gly Val Ile 
1               5                   10                  15      


Pro Val Ala Lys Thr Leu Arg Asn Glu Leu Arg Pro Val Gly His Thr 
            20                  25                  30          


Gln Glu His Ile Ile Gln Asn Gly Leu Ile Gln Glu Asp Glu Leu Arg 
        35                  40                  45              


Gln Glu Lys Ser Thr Glu Leu Lys Asn Ile Met Asp Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Tyr Ile Asp Lys Ser Leu Ser Gly Val Thr Asp Leu Asp Phe Thr 
65                  70                  75                  80  


Leu Leu Phe Glu Leu Met Asn Leu Val Gln Ser Ser Pro Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Ala Leu Glu Lys Glu Gln Ser Lys Met Arg Glu Gln Ile 
            100                 105                 110         


Cys Thr His Leu Gln Ser Asp Ser Asn Tyr Lys Asn Ile Phe Asn Ala 
        115                 120                 125             


Lys Leu Leu Lys Glu Ile Leu Pro Asp Phe Ile Lys Asn Tyr Asn Gln 
    130                 135                 140                 


Tyr Asp Val Lys Asp Lys Ala Gly Lys Leu Glu Thr Leu Ala Leu Phe 
145                 150                 155                 160 


Asn Gly Phe Ser Thr Tyr Phe Thr Asp Phe Phe Glu Lys Arg Lys Asn 
                165                 170                 175     


Val Phe Thr Lys Glu Ala Val Ser Thr Ser Ile Ala Tyr Arg Ile Val 
            180                 185                 190         


His Glu Asn Ser Leu Ile Phe Leu Ala Asn Met Thr Ser Tyr Lys Lys 
        195                 200                 205             


Ile Ser Glu Lys Ala Leu Asp Glu Ile Glu Val Ile Glu Lys Asn Asn 
    210                 215                 220                 


Gln Asp Lys Met Gly Asp Trp Glu Leu Asn Gln Ile Phe Asn Pro Asp 
225                 230                 235                 240 


Phe Tyr Asn Met Val Leu Ile Gln Ser Gly Ile Asp Phe Tyr Asn Glu 
                245                 250                 255     


Ile Cys Gly Val Val Asn Ala His Met Asn Leu Tyr Cys Gln Gln Thr 
            260                 265                 270         


Lys Asn Asn Tyr Asn Leu Phe Lys Met Arg Lys Leu His Lys Gln Ile 
        275                 280                 285             


Leu Ala Tyr Thr Ser Thr Ser Phe Glu Val Pro Lys Met Phe Glu Asp 
    290                 295                 300                 


Asp Met Ser Val Tyr Asn Ala Val Asn Ala Phe Ile Asp Glu Thr Glu 
305                 310                 315                 320 


Lys Gly Asn Ile Ile Gly Lys Leu Lys Asp Ile Val Asn Lys Tyr Asp 
                325                 330                 335     


Glu Leu Asp Glu Lys Arg Ile Tyr Ile Ser Lys Asp Phe Tyr Glu Thr 
            340                 345                 350         


Leu Ser Cys Phe Met Ser Gly Asn Trp Asn Leu Ile Thr Gly Cys Val 
        355                 360                 365             


Glu Asn Phe Tyr Asp Glu Asn Ile His Ala Lys Gly Lys Ser Lys Glu 
    370                 375                 380                 


Glu Lys Val Lys Lys Ala Val Lys Glu Asp Lys Tyr Lys Ser Ile Asn 
385                 390                 395                 400 


Asp Val Asn Asp Leu Val Glu Lys Tyr Ile Asp Glu Lys Glu Arg Asn 
                405                 410                 415     


Glu Phe Lys Asn Ser Asn Ala Lys Gln Tyr Ile Arg Glu Ile Ser Asn 
            420                 425                 430         


Ile Ile Thr Asp Thr Glu Thr Ala His Leu Glu Tyr Asp Asp His Ile 
        435                 440                 445             


Ser Leu Ile Glu Ser Glu Glu Lys Ala Asp Glu Met Lys Lys Arg Leu 
    450                 455                 460                 


Asp Met Tyr Met Asn Met Tyr His Trp Ala Lys Ala Phe Ile Val Asp 
465                 470                 475                 480 


Glu Val Leu Asp Arg Asp Glu Met Phe Tyr Ser Asp Ile Asp Asp Ile 
                485                 490                 495     


Tyr Asn Ile Leu Glu Asn Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
            500                 505                 510         


Tyr Val Thr Gln Lys Pro Tyr Asn Ser Lys Lys Ile Lys Leu Asn Phe 
        515                 520                 525             


Gln Ser Pro Thr Leu Ala Asn Gly Trp Ser Gln Ser Lys Glu Phe Asp 
    530                 535                 540                 


Asn Asn Ala Ile Ile Leu Ile Arg Asp Asn Lys Tyr Tyr Leu Ala Ile 
545                 550                 555                 560 


Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Gln Gly Asn Ser 
                565                 570                 575     


Asp Lys Lys Asn Asp Asn Asp Tyr Lys Lys Met Val Tyr Asn Leu Leu 
            580                 585                 590         


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Leu Ser Lys Lys Gly 
        595                 600                 605             


Ile Glu Thr Phe Lys Pro Ser Asp Tyr Ile Ile Ser Gly Tyr Asn Ala 
    610                 615                 620                 


His Lys His Ile Lys Thr Ser Glu Asn Phe Asp Ile Ser Phe Cys Arg 
625                 630                 635                 640 


Asp Leu Ile Asp Tyr Phe Lys Asn Ser Ile Glu Lys His Ala Glu Trp 
                645                 650                 655     


Arg Lys Tyr Glu Phe Lys Phe Ser Ala Thr Asp Ser Tyr Ser Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Val Glu Met Gln Gly Tyr Arg Ile Asp Trp 
        675                 680                 685             


Thr Tyr Ile Ser Glu Ala Asp Ile Asn Lys Leu Asp Glu Glu Gly Lys 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Glu Asn Ser Thr 
705                 710                 715                 720 


Gly Lys Glu Asn Leu His Thr Met Tyr Phe Lys Asn Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Asp Lys Ile Ile Lys Leu Asn Gly Gln Ala Glu Leu Phe 
            740                 745                 750         


Tyr Arg Arg Ala Ser Val Lys Asn Pro Val Lys His Lys Lys Asp Ser 
        755                 760                 765             


Val Leu Val Asn Lys Thr Tyr Lys Asn Gln Leu Asp Asn Gly Asp Val 
    770                 775                 780                 


Val Arg Ile Pro Ile Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Lys Met 
785                 790                 795                 800 


Tyr Asn Gly Tyr Ile Lys Glu Ser Asp Leu Ser Glu Ala Ala Lys Glu 
                805                 810                 815     


Tyr Leu Asp Lys Val Glu Val Arg Thr Ala Gln Lys Asp Ile Val Lys 
            820                 825                 830         


Asp Tyr Arg Tyr Thr Val Asp Lys Tyr Phe Ile His Thr Pro Ile Thr 
        835                 840                 845             


Ile Asn Tyr Lys Val Thr Ala Arg Asn Asn Val Asn Asp Met Val Val 
    850                 855                 860                 


Lys Tyr Ile Ala Gln Asn Asp Asp Ile His Val Ile Gly Ile Asp Arg 
865                 870                 875                 880 


Gly Glu Arg Asn Leu Ile Tyr Ile Ser Val Ile Asp Ser His Gly Asn 
                885                 890                 895     


Ile Val Lys Gln Lys Ser Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr Lys 
            900                 905                 910         


Lys Lys Leu Val Glu Lys Glu Lys Thr Arg Glu Tyr Ala Arg Lys Asn 
        915                 920                 925             


Trp Lys Ser Ile Gly Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser 
    930                 935                 940                 


Gly Val Val His Glu Ile Ala Met Leu Ile Val Glu Tyr Asn Ala Ile 
945                 950                 955                 960 


Ile Ala Met Glu Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys 
                965                 970                 975     


Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn Lys 
            980                 985                 990         


Leu Asn Tyr Phe Ala Ser Lys Glu  Lys Ser Val Asp Glu  Pro Gly Gly 
        995                 1000                 1005             


Leu Leu  Lys Gly Tyr Gln Leu  Thr Tyr Val Pro Asp  Asn Ile Lys 
    1010                 1015                 1020             


Asn Leu  Gly Lys Gln Cys Gly  Val Ile Phe Tyr Val  Pro Ala Ala 
    1025                 1030                 1035             


Phe Thr  Ser Lys Ile Asp Pro  Ser Thr Gly Phe Ile  Ser Ala Phe 
    1040                 1045                 1050             


Asn Phe  Lys Ser Ile Ser Thr  Asn Ala Ser Arg Lys  Gln Phe Phe 
    1055                 1060                 1065             


Met Gln  Phe Asp Glu Ile Arg  Tyr Cys Ala Glu Lys  Asp Met Phe 
    1070                 1075                 1080             


Ser Phe  Gly Phe Asp Tyr Asn  Asn Phe Asp Thr Tyr  Asn Ile Thr 
    1085                 1090                 1095             


Met Gly  Lys Thr Gln Trp Thr  Val Tyr Thr Asn Gly  Glu Arg Leu 
    1100                 1105                 1110             


Gln Ser  Glu Phe Asn Asn Ala  Arg Arg Thr Gly Lys  Thr Lys Ser 
    1115                 1120                 1125             


Ile Asn  Leu Thr Glu Thr Ile  Lys Leu Leu Leu Glu  Asp Asn Glu 
    1130                 1135                 1140             


Ile Asn  Tyr Ala Asp Gly His  Asp Ile Arg Ile Asp  Met Glu Lys 
    1145                 1150                 1155             


Met Asp  Glu Asp Lys Lys Ser  Glu Phe Phe Ala Gln  Leu Leu Ser 
    1160                 1165                 1170             


Leu Tyr  Lys Leu Thr Val Gln  Met Arg Asn Ser Tyr  Thr Glu Ala 
    1175                 1180                 1185             


Glu Glu  Gln Glu Asn Gly Ile  Ser Tyr Asp Lys Ile  Ile Ser Pro 
    1190                 1195                 1200             


Val Ile  Asn Asp Glu Gly Glu  Phe Phe Asp Ser Asp  Asn Tyr Lys 
    1205                 1210                 1215             


Glu Ser  Asp Asp Lys Glu Cys  Lys Met Pro Lys Asp  Ala Asp Ala 
    1220                 1225                 1230             


Asn Gly  Ala Tyr Cys Ile Ala  Leu Lys Gly Leu Tyr  Glu Val Leu 
    1235                 1240                 1245             


Lys Ile  Lys Ser Glu Trp Thr  Glu Asp Gly Phe Asp  Arg Asn Cys 
    1250                 1255                 1260             


Leu Lys  Leu Pro His Ala Glu  Trp Leu Asp Phe Ile  Gln Asn Lys 
    1265                 1270                 1275             


Arg Tyr  Glu 
    1280     


<210>  6
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  6

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Val Asn Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  7
<211>  1206
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  7

Met Tyr Tyr Glu Ser Leu Thr Lys Gln Tyr Pro Val Ser Lys Thr Ile 
1               5                   10                  15      


Arg Asn Glu Leu Ile Pro Ile Gly Lys Thr Leu Asp Asn Ile Arg Gln 
            20                  25                  30          


Asn Asn Ile Leu Glu Ser Asp Val Lys Arg Lys Gln Asn Tyr Glu His 
        35                  40                  45              


Val Lys Gly Ile Leu Asp Glu Tyr His Lys Gln Leu Ile Asn Glu Ala 
    50                  55                  60                  


Leu Asp Asn Cys Thr Leu Pro Ser Leu Lys Ile Ala Ala Glu Ile Tyr 
65                  70                  75                  80  


Leu Lys Asn Gln Lys Glu Val Ser Asp Arg Glu Asp Phe Asn Lys Thr 
                85                  90                  95      


Gln Asp Leu Leu Arg Lys Glu Val Val Glu Lys Leu Lys Ala His Glu 
            100                 105                 110         


Asn Phe Thr Lys Ile Gly Lys Lys Asp Ile Leu Asp Leu Leu Glu Lys 
        115                 120                 125             


Leu Pro Ser Ile Ser Glu Asp Asp Tyr Asn Ala Leu Glu Ser Phe Arg 
    130                 135                 140                 


Asn Phe Tyr Thr Tyr Phe Thr Ser Tyr Asn Lys Val Arg Glu Asn Leu 
145                 150                 155                 160 


Tyr Ser Asp Lys Glu Lys Ser Ser Thr Val Ala Tyr Arg Leu Ile Asn 
                165                 170                 175     


Glu Asn Phe Pro Lys Phe Leu Asp Asn Val Lys Ser Tyr Arg Phe Val 
            180                 185                 190         


Lys Thr Ala Gly Ile Leu Ala Asp Gly Leu Gly Glu Glu Glu Gln Asp 
        195                 200                 205             


Ser Leu Phe Ile Val Glu Thr Phe Asn Lys Thr Leu Thr Gln Asp Gly 
    210                 215                 220                 


Ile Asp Thr Tyr Asn Ser Gln Val Gly Lys Ile Asn Ser Ser Ile Asn 
225                 230                 235                 240 


Leu Tyr Asn Gln Lys Asn Gln Lys Ala Asn Gly Phe Arg Lys Ile Pro 
                245                 250                 255     


Lys Met Lys Met Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Glu Ser 
            260                 265                 270         


Phe Ile Asp Glu Phe Gln Ser Asp Glu Val Leu Ile Asp Asn Val Glu 
        275                 280                 285             


Ser Tyr Gly Ser Val Leu Ile Glu Ser Leu Lys Ser Ser Lys Val Ser 
    290                 295                 300                 


Ala Phe Phe Asp Ala Leu Arg Glu Ser Lys Gly Lys Asn Val Tyr Val 
305                 310                 315                 320 


Lys Asn Asp Leu Ala Lys Thr Ala Met Ser Val Ile Val Phe Glu Asn 
                325                 330                 335     


Trp Arg Thr Phe Asp Asp Leu Leu Asn Gln Glu Tyr Asp Leu Ala Asn 
            340                 345                 350         


Glu Asn Lys Lys Lys Asp Asp Lys Tyr Phe Glu Lys Arg Gln Lys Glu 
        355                 360                 365             


Leu Lys Lys Asn Lys Ser Tyr Ser Leu Glu His Leu Cys Asn Leu Ser 
    370                 375                 380                 


Glu Asp Ser Cys Asn Leu Ile Glu Asn Tyr Ile His Gln Ile Ser Asp 
385                 390                 395                 400 


Asp Ile Glu Asn Ile Ile Ile Asn Asn Glu Thr Phe Leu Arg Ile Val 
                405                 410                 415     


Ile Asn Glu His Asp Arg Ser Arg Lys Leu Ala Lys Asn Arg Lys Ala 
            420                 425                 430         


Val Lys Ala Ile Lys Asp Phe Leu Asp Ser Ile Lys Val Leu Glu Arg 
        435                 440                 445             


Glu Leu Lys Leu Ile Asn Ser Ser Gly Gln Glu Leu Glu Lys Asp Leu 
    450                 455                 460                 


Ile Val Tyr Ser Ala His Glu Glu Leu Leu Val Glu Leu Lys Gln Val 
465                 470                 475                 480 


Asp Ser Leu Tyr Asn Met Thr Arg Asn Tyr Leu Thr Lys Lys Pro Phe 
                485                 490                 495     


Ser Thr Glu Lys Val Lys Leu Asn Phe Asn Arg Ser Thr Leu Leu Asn 
            500                 505                 510         


Gly Trp Asp Arg Asn Lys Glu Thr Asp Asn Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Lys Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Thr Ser Ala Asn Lys 
    530                 535                 540                 


Ala Phe Val Asn Pro Pro Val Ala Lys Thr Glu Lys Val Phe Lys Lys 
545                 550                 555                 560 


Val Asp Tyr Lys Leu Leu Pro Val Pro Asn Gln Met Leu Pro Lys Val 
                565                 570                 575     


Phe Phe Ala Lys Ser Asn Ile Asp Phe Tyr Asn Pro Ser Ser Glu Ile 
            580                 585                 590         


Tyr Ser Asn Tyr Lys Lys Gly Thr His Lys Lys Gly Asn Met Phe Ser 
        595                 600                 605             


Leu Glu Asp Cys His Asn Leu Ile Asp Phe Phe Lys Glu Ser Ile Ser 
    610                 615                 620                 


Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Asp Thr Gln Ala 
625                 630                 635                 640 


Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val Glu Lys Gln Gly 
                645                 650                 655     


Tyr Lys Leu Thr Tyr Thr Asp Ile Asp Glu Thr Tyr Ile Asn Asp Leu 
            660                 665                 670         


Ile Glu Arg Asn Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
        675                 680                 685             


Ser Met Tyr Ser Lys Gly Lys Leu Asn Leu His Thr Leu Tyr Phe Met 
    690                 695                 700                 


Met Leu Phe Asp Gln Arg Asn Ile Asp Asp Val Val Tyr Lys Leu Asn 
705                 710                 715                 720 


Gly Glu Ala Glu Val Phe Tyr Arg Pro Ala Ser Ile Ser Glu Asp Glu 
                725                 730                 735     


Leu Ile Ile His Lys Ala Gly Glu Glu Ile Lys Asn Lys Asn Pro Asn 
            740                 745                 750         


Arg Ala Arg Thr Lys Glu Thr Ser Thr Phe Ser Tyr Asp Ile Val Lys 
        755                 760                 765             


Asp Lys Arg Tyr Ser Lys Asp Lys Phe Thr Leu His Ile Pro Ile Thr 
    770                 775                 780                 


Met Asn Phe Gly Val Asp Glu Val Lys Arg Phe Asn Asp Ala Val Asn 
785                 790                 795                 800 


Ser Ala Ile Arg Ile Asp Glu Asn Val Asn Val Ile Gly Ile Asp Arg 
                805                 810                 815     


Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Ser Lys Gly Asn 
            820                 825                 830         


Ile Leu Glu Gln Ile Ser Leu Asn Ser Ile Ile Asn Lys Glu Tyr Asp 
        835                 840                 845             


Ile Glu Thr Asp Tyr His Ala Leu Leu Asp Glu Arg Glu Gly Gly Arg 
    850                 855                 860                 


Asp Lys Ala Arg Lys Asp Trp Asn Thr Val Glu Asn Ile Arg Asp Leu 
865                 870                 875                 880 


Lys Ala Gly Leu Tyr Leu Gln Val Val Asn Val Val Ala Lys Leu Val 
                885                 890                 895     


Leu Lys Tyr Asn Ala Ile Ile Cys Leu Glu Asp Leu Asn Phe Gly Phe 
            900                 905                 910         


Lys Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu 
        915                 920                 925             


Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Ile Asp Lys Ser Arg 
    930                 935                 940                 


Glu Gln Thr Ser Pro Lys Glu Leu Gly Gly Ala Leu Asn Ala Leu Gln 
945                 950                 955                 960 


Leu Thr Ser Lys Phe Lys Ser Phe Lys Glu Leu Gly Lys Gln Ser Gly 
                965                 970                 975     


Val Ile Tyr Tyr Val Pro Ala Tyr Leu Thr Ser Lys Ile Asp Pro Thr 
            980                 985                 990         


Thr Gly Phe Ala Asn Leu Phe Tyr  Met Lys Cys Glu Asn  Val Glu Lys 
        995                 1000                 1005             


Ser Lys  Arg Phe Phe Asp Gly  Phe Asp Phe Ile Arg  Phe Asn Ala 
    1010                 1015                 1020             


Leu Glu  Asn Val Phe Glu Phe  Gly Phe Asp Tyr Arg  Ser Phe Thr 
    1025                 1030                 1035             


Gln Arg  Ala Cys Gly Ile Asn  Ser Lys Trp Thr Val  Cys Thr Asn 
    1040                 1045                 1050             


Gly Glu  Arg Ile Ile Lys Tyr  Arg Asn Pro Asp Lys  Asn Asn Met 
    1055                 1060                 1065             


Phe Asp  Glu Lys Val Val Val  Val Thr Asp Glu Met  Lys Asn Leu 
    1070                 1075                 1080             


Phe Glu  Gln Tyr Lys Ile Pro  Tyr Glu Asp Gly Arg  Asn Val Lys 
    1085                 1090                 1095             


Asp Met  Ile Ile Ser Asn Glu  Glu Ala Glu Phe Tyr  Arg Arg Leu 
    1100                 1105                 1110             


Tyr Arg  Leu Leu Gln Gln Thr  Leu Gln Met Arg Asn  Ser Thr Ser 
    1115                 1120                 1125             


Asp Gly  Thr Arg Asp Tyr Ile  Ile Ser Pro Val Lys  Asn Lys Arg 
    1130                 1135                 1140             


Glu Ala  Tyr Phe Asn Ser Glu  Leu Ser Asp Gly Ser  Val Pro Lys 
    1145                 1150                 1155             


Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu 
    1160                 1165                 1170             


Trp Val  Leu Glu Gln Ile Arg  Gln Lys Ser Glu Gly  Glu Lys Ile 
    1175                 1180                 1185             


Asn Leu  Ala Met Thr Asn Ala  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1190                 1195                 1200             


His Leu  Leu 
    1205     


<210>  8
<211>  1233
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  8

Met Asp Tyr Gly Asn Gly Gln Phe Glu Arg Arg Ala Pro Leu Thr Lys 
1               5                   10                  15      


Thr Ile Thr Leu Arg Leu Lys Pro Ile Gly Glu Thr Arg Glu Thr Ile 
            20                  25                  30          


Arg Glu Gln Lys Leu Leu Glu Gln Asp Ala Ala Phe Arg Lys Leu Val 
        35                  40                  45              


Glu Thr Val Thr Pro Ile Val Asp Asp Cys Ile Arg Lys Ile Ala Asp 
    50                  55                  60                  


Asn Ala Leu Cys His Phe Gly Thr Glu Tyr Asp Phe Ser Cys Leu Gly 
65                  70                  75                  80  


Asn Ala Ile Ser Lys Asn Asp Ser Lys Ala Ile Lys Lys Glu Thr Glu 
                85                  90                  95      


Lys Val Glu Lys Leu Leu Ala Lys Val Leu Thr Glu Asn Leu Pro Asp 
            100                 105                 110         


Gly Leu Arg Lys Val Asn Asp Ile Asn Ser Ala Ala Phe Ile Gln Asp 
        115                 120                 125             


Thr Leu Thr Ser Phe Val Gln Asp Asp Ala Asp Lys Arg Val Leu Ile 
    130                 135                 140                 


Gln Glu Leu Lys Gly Lys Thr Val Leu Met Gln Arg Phe Leu Thr Thr 
145                 150                 155                 160 


Arg Ile Thr Ala Leu Thr Val Trp Leu Pro Asp Arg Val Phe Glu Asn 
                165                 170                 175     


Phe Asn Ile Phe Ile Glu Asn Ala Glu Lys Met Arg Ile Leu Leu Asp 
            180                 185                 190         


Ser Pro Leu Asn Glu Lys Ile Met Lys Phe Asp Pro Asp Ala Glu Gln 
        195                 200                 205             


Tyr Ala Ser Leu Glu Phe Tyr Gly Gln Cys Leu Ser Gln Lys Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Leu Ile Ile Ser Gly Ile Tyr Ala Asp Asp Glu Val 
225                 230                 235                 240 


Lys Asn Pro Gly Ile Asn Glu Ile Val Lys Glu Tyr Asn Gln Gln Ile 
                245                 250                 255     


Arg Gly Asp Lys Asp Glu Ser Pro Leu Pro Lys Leu Lys Lys Leu His 
            260                 265                 270         


Lys Gln Ile Leu Met Pro Val Glu Lys Ala Phe Phe Val Arg Val Leu 
        275                 280                 285             


Ser Asn Asp Ser Asp Ala Arg Ser Ile Leu Glu Lys Ile Leu Lys Asp 
    290                 295                 300                 


Thr Glu Met Leu Pro Ser Lys Ile Ile Glu Ala Met Lys Glu Ala Asp 
305                 310                 315                 320 


Ala Gly Asp Ile Ala Val Tyr Gly Ser Arg Leu His Glu Leu Ser His 
                325                 330                 335     


Val Ile Tyr Gly Asp His Gly Lys Leu Ser Gln Ile Ile Tyr Asp Lys 
            340                 345                 350         


Glu Ser Lys Arg Ile Ser Glu Leu Met Glu Thr Leu Ser Pro Lys Glu 
        355                 360                 365             


Arg Lys Glu Ser Lys Lys Arg Leu Glu Gly Leu Glu Glu His Ile Arg 
    370                 375                 380                 


Lys Ser Thr Tyr Thr Phe Asp Glu Leu Asn Arg Tyr Ala Glu Lys Asn 
385                 390                 395                 400 


Val Met Ala Ala Tyr Ile Ala Ala Val Glu Glu Ser Cys Ala Glu Ile 
                405                 410                 415     


Met Arg Lys Glu Lys Asp Leu Arg Thr Leu Leu Ser Lys Glu Asp Val 
            420                 425                 430         


Lys Ile Arg Gly Asn Arg His Asn Thr Leu Ile Val Lys Asn Tyr Phe 
        435                 440                 445             


Asn Ala Trp Thr Val Phe Arg Asn Leu Ile Arg Ile Leu Arg Arg Lys 
    450                 455                 460                 


Ser Glu Ala Glu Ile Asp Ser Asp Phe Tyr Asp Val Leu Asp Asp Ser 
465                 470                 475                 480 


Val Glu Val Leu Ser Leu Thr Tyr Lys Gly Glu Asn Leu Cys Arg Ser 
                485                 490                 495     


Tyr Ile Thr Lys Lys Ile Gly Ser Asp Leu Lys Pro Glu Ile Ala Thr 
            500                 505                 510         


Tyr Gly Ser Ala Leu Arg Pro Asn Ser Arg Trp Trp Ser Pro Gly Glu 
        515                 520                 525             


Lys Phe Asn Val Lys Phe His Thr Ile Val Arg Arg Asp Gly Arg Leu 
    530                 535                 540                 


Tyr Tyr Phe Ile Leu Pro Lys Gly Ala Lys Pro Val Glu Leu Glu Asp 
545                 550                 555                 560 


Met Asp Gly Asp Ile Glu Cys Leu Gln Met Arg Lys Ile Pro Asn Pro 
                565                 570                 575     


Thr Ile Phe Leu Pro Lys Leu Val Phe Lys Asp Pro Glu Ala Phe Phe 
            580                 585                 590         


Arg Asp Asn Pro Glu Ala Asp Glu Phe Val Phe Leu Ser Gly Met Lys 
        595                 600                 605             


Ala Pro Val Thr Ile Thr Arg Glu Thr Tyr Glu Ala Tyr Arg Tyr Lys 
    610                 615                 620                 


Leu Tyr Thr Val Gly Lys Leu Arg Asp Gly Glu Val Ser Glu Glu Glu 
625                 630                 635                 640 


Tyr Lys Arg Ala Leu Leu Gln Val Leu Thr Ala Tyr Lys Glu Phe Leu 
                645                 650                 655     


Glu Asn Arg Met Ile Tyr Ala Asp Leu Asn Phe Gly Phe Lys Asp Leu 
            660                 665                 670         


Glu Glu Tyr Lys Asp Ser Ser Glu Phe Ile Lys Gln Val Glu Thr His 
        675                 680                 685             


Asn Thr Phe Met Cys Trp Ala Lys Val Ser Ser Ser Gln Leu Asp Asp 
    690                 695                 700                 


Leu Val Lys Ser Gly Asn Gly Leu Leu Phe Glu Ile Trp Ser Glu Arg 
705                 710                 715                 720 


Leu Glu Ser Tyr Tyr Lys Tyr Gly Asn Glu Lys Val Leu Arg Gly Tyr 
                725                 730                 735     


Glu Gly Val Leu Leu Ser Ile Leu Lys Asp Glu Asn Leu Val Ser Met 
            740                 745                 750         


Arg Thr Leu Leu Asn Ser Arg Pro Met Leu Val Tyr Arg Pro Lys Glu 
        755                 760                 765             


Ser Ser Lys Pro Met Val Val His Arg Asp Gly Ser Arg Val Val Asp 
    770                 775                 780                 


Arg Phe Asp Lys Asp Gly Lys Tyr Ile Pro Pro Glu Val His Asp Glu 
785                 790                 795                 800 


Leu Tyr Arg Phe Phe Asn Asn Leu Leu Ile Lys Glu Lys Leu Gly Glu 
                805                 810                 815     


Lys Ala Arg Lys Ile Leu Asp Asn Lys Lys Val Lys Val Lys Val Leu 
            820                 825                 830         


Glu Ser Glu Arg Val Lys Trp Ser Lys Phe Tyr Asp Glu Gln Phe Ala 
        835                 840                 845             


Val Thr Phe Ser Val Lys Lys Asn Ala Asp Cys Leu Asp Thr Thr Lys 
    850                 855                 860                 


Asp Leu Asn Ala Glu Val Met Glu Gln Tyr Ser Glu Ser Asn Arg Leu 
865                 870                 875                 880 


Ile Leu Ile Arg Asn Thr Thr Asp Ile Leu Tyr Tyr Leu Val Leu Asp 
                885                 890                 895     


Lys Asn Gly Lys Val Leu Lys Gln Arg Ser Leu Asn Ile Ile Asn Asp 
            900                 905                 910         


Gly Ala Arg Asp Val Asp Trp Lys Glu Arg Phe Arg Gln Val Thr Lys 
        915                 920                 925             


Asp Arg Asn Glu Gly Tyr Asn Glu Trp Asp Tyr Ser Arg Thr Ser Asn 
    930                 935                 940                 


Asp Leu Lys Glu Val Tyr Leu Asn Tyr Ala Leu Lys Glu Ile Ala Glu 
945                 950                 955                 960 


Ala Val Ile Glu Tyr Asn Ala Ile Leu Ile Ile Glu Lys Met Ser Asn 
                965                 970                 975     


Ala Phe Lys Asp Lys Tyr Ser Phe Leu Asp Asp Val Thr Phe Lys Gly 
            980                 985                 990         


Phe Glu Thr Lys Lys Leu Ala Lys  Leu Ser Asp Leu His  Phe Arg Gly 
        995                 1000                 1005             


Ile Lys  Asp Gly Glu Pro Cys  Ser Phe Thr Asn Pro  Leu Gln Leu 
    1010                 1015                 1020             


Cys Gln  Asn Asp Ser Asn Lys  Ile Leu Gln Asp Gly  Val Ile Phe 
    1025                 1030                 1035             


Met Val  Pro Asn Ser Met Thr  Arg Ser Leu Asp Pro  Asp Thr Gly 
    1040                 1045                 1050             


Phe Ile  Phe Ala Ile Asn Asp  His Asn Ile Arg Thr  Lys Lys Ala 
    1055                 1060                 1065             


Lys Leu  Asn Phe Leu Ser Lys  Phe Asp Gln Leu Lys  Val Ser Ser 
    1070                 1075                 1080             


Glu Gly  Cys Leu Ile Met Lys  Tyr Ser Gly Asp Ser  Leu Pro Thr 
    1085                 1090                 1095             


His Asn  Thr Asp Asn Arg Val  Trp Asn Cys Cys Cys  Asn His Pro 
    1100                 1105                 1110             


Ile Thr  Asn Tyr Asp Arg Glu  Thr Lys Lys Val Glu  Phe Ile Glu 
    1115                 1120                 1125             


Glu Pro  Val Glu Glu Leu Ser  Arg Val Leu Glu Glu  Asn Gly Ile 
    1130                 1135                 1140             


Glu Thr  Asp Thr Glu Leu Asn  Lys Leu Asn Glu Arg  Glu Asn Val 
    1145                 1150                 1155             


Pro Gly  Lys Val Val Asp Ala  Ile Tyr Ser Leu Val  Leu Asn Tyr 
    1160                 1165                 1170             


Leu Arg  Gly Thr Val Ser Gly  Val Ala Gly Gln Arg  Ala Val Tyr 
    1175                 1180                 1185             


Tyr Ser  Pro Val Thr Gly Lys  Lys Tyr Asp Ile Ser  Phe Ile Gln 
    1190                 1195                 1200             


Ala Met  Asn Leu Asn Arg Lys  Cys Asp Tyr Tyr Arg  Ile Gly Ser 
    1205                 1210                 1215             


Lys Glu  Arg Gly Glu Trp Thr  Asp Phe Val Ala Gln  Leu Ile Asn 
    1220                 1225                 1230             


<210>  9
<211>  1227
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  9

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Asn Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ser Asn Lys  Glu Trp Leu 
    1205                 1210                 1215             


Glu Tyr  Ala Gln Thr Ser Val  Lys His 
    1220                 1225         


<210>  10
<211>  1264
<212>  PRT
<213>  Leptospira inadai

<400>  10

Met Glu Asp Tyr Ser Gly Phe Val Asn Ile Tyr Ser Ile Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu His Ile Glu 
            20                  25                  30          


Lys Lys Gly Phe Leu Lys Lys Asp Lys Ile Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Ile Ile Asp Lys Tyr His Arg Ala Tyr Ile Glu Glu 
    50                  55                  60                  


Val Phe Asp Ser Val Leu His Gln Lys Lys Lys Lys Asp Lys Thr Arg 
65                  70                  75                  80  


Phe Ser Thr Gln Phe Ile Lys Glu Ile Lys Glu Phe Ser Glu Leu Tyr 
                85                  90                  95      


Tyr Lys Thr Glu Lys Asn Ile Pro Asp Lys Glu Arg Leu Glu Ala Leu 
            100                 105                 110         


Ser Glu Lys Leu Arg Lys Met Leu Val Gly Ala Phe Lys Gly Glu Phe 
        115                 120                 125             


Ser Glu Glu Val Ala Glu Lys Tyr Asn Lys Asn Leu Phe Ser Lys Glu 
    130                 135                 140                 


Leu Ile Arg Asn Glu Ile Glu Lys Phe Cys Glu Thr Asp Glu Glu Arg 
145                 150                 155                 160 


Lys Gln Val Ser Asn Phe Lys Ser Phe Thr Thr Tyr Phe Thr Gly Phe 
                165                 170                 175     


His Ser Asn Arg Gln Asn Ile Tyr Ser Asp Glu Lys Lys Ser Thr Ala 
            180                 185                 190         


Ile Gly Tyr Arg Ile Ile His Gln Asn Leu Pro Lys Phe Leu Asp Asn 
        195                 200                 205             


Leu Lys Ile Ile Glu Ser Ile Gln Arg Arg Phe Lys Asp Phe Pro Trp 
    210                 215                 220                 


Ser Asp Leu Lys Lys Asn Leu Lys Lys Ile Asp Lys Asn Ile Lys Leu 
225                 230                 235                 240 


Thr Glu Tyr Phe Ser Ile Asp Gly Phe Val Asn Val Leu Asn Gln Lys 
                245                 250                 255     


Gly Ile Asp Ala Tyr Asn Thr Ile Leu Gly Gly Lys Ser Glu Glu Ser 
            260                 265                 270         


Gly Glu Lys Ile Gln Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Arg Gln 
        275                 280                 285             


Lys Asn Asn Ile Asp Arg Lys Asn Pro Leu Asn Val Lys Ile Leu Phe 
    290                 295                 300                 


Lys Gln Ile Leu Gly Asp Arg Glu Thr Lys Ser Phe Ile Pro Glu Ala 
305                 310                 315                 320 


Phe Pro Asp Asp Gln Ser Val Leu Asn Ser Ile Thr Glu Phe Ala Lys 
                325                 330                 335     


Tyr Leu Lys Leu Asp Lys Lys Lys Lys Ser Ile Ile Ala Glu Leu Lys 
            340                 345                 350         


Lys Phe Leu Ser Ser Phe Asn Arg Tyr Glu Leu Asp Gly Ile Tyr Leu 
        355                 360                 365             


Ala Asn Asp Asn Ser Leu Ala Ser Ile Ser Thr Phe Leu Phe Asp Asp 
    370                 375                 380                 


Trp Ser Phe Ile Lys Lys Ser Val Ser Phe Lys Tyr Asp Glu Ser Val 
385                 390                 395                 400 


Gly Asp Pro Lys Lys Lys Ile Lys Ser Pro Leu Lys Tyr Glu Lys Glu 
                405                 410                 415     


Lys Glu Lys Trp Leu Lys Gln Lys Tyr Tyr Thr Ile Ser Phe Leu Asn 
            420                 425                 430         


Asp Ala Ile Glu Ser Tyr Ser Lys Ser Gln Asp Glu Lys Arg Val Lys 
        435                 440                 445             


Ile Arg Leu Glu Ala Tyr Phe Ala Glu Phe Lys Ser Lys Asp Asp Ala 
    450                 455                 460                 


Lys Lys Gln Phe Asp Leu Leu Glu Arg Ile Glu Glu Ala Tyr Ala Ile 
465                 470                 475                 480 


Val Glu Pro Leu Leu Gly Ala Glu Tyr Pro Arg Asp Arg Asn Leu Lys 
                485                 490                 495     


Ala Asp Lys Lys Glu Val Gly Lys Ile Lys Asp Phe Leu Asp Ser Ile 
            500                 505                 510         


Lys Ser Leu Gln Phe Phe Leu Lys Pro Leu Leu Ser Ala Glu Ile Phe 
        515                 520                 525             


Asp Glu Lys Asp Leu Gly Phe Tyr Asn Gln Leu Glu Gly Tyr Tyr Glu 
    530                 535                 540                 


Glu Ile Asp Ile Ser Gly His Leu Tyr Asn Lys Val Arg Asn Tyr Leu 
545                 550                 555                 560 


Thr Gly Lys Ile Tyr Ser Lys Glu Lys Phe Lys Leu Asn Phe Glu Asn 
                565                 570                 575     


Ser Thr Leu Leu Lys Gly Trp Asp Glu Asn Arg Glu Val Ala Asn Leu 
            580                 585                 590         


Cys Val Ile Phe Arg Glu Asp Gln Lys Tyr Tyr Leu Gly Val Met Asp 
        595                 600                 605             


Lys Glu Asn Asn Thr Ile Leu Ser Asp Ile Pro Lys Val Lys Pro Asn 
    610                 615                 620                 


Glu Leu Phe Tyr Glu Lys Met Val Tyr Lys Leu Ile Pro Thr Pro His 
625                 630                 635                 640 


Met Gln Leu Pro Arg Ile Ile Phe Ser Ser Asp Asn Leu Ser Ile Tyr 
                645                 650                 655     


Asn Pro Ser Lys Ser Ile Leu Lys Ile Arg Glu Ala Lys Ser Phe Lys 
            660                 665                 670         


Glu Gly Lys Asn Phe Lys Leu Lys Asp Cys His Lys Phe Ile Asp Phe 
        675                 680                 685             


Tyr Lys Glu Ser Ile Ser Lys Asn Glu Asp Trp Ser Arg Phe Asp Phe 
    690                 695                 700                 


Lys Phe Ser Lys Thr Ser Ser Tyr Glu Asn Ile Ser Glu Phe Tyr Arg 
705                 710                 715                 720 


Glu Val Glu Arg Gln Gly Tyr Asn Leu Asp Phe Lys Lys Val Ser Lys 
                725                 730                 735     


Phe Tyr Ile Asp Ser Leu Val Glu Asp Gly Lys Leu Tyr Leu Phe Gln 
            740                 745                 750         


Ile Tyr Asn Lys Asp Phe Ser Ile Phe Ser Lys Gly Lys Pro Asn Leu 
        755                 760                 765             


His Thr Ile Tyr Phe Arg Ser Leu Phe Ser Lys Glu Asn Leu Lys Asp 
    770                 775                 780                 


Val Cys Leu Lys Leu Asn Gly Glu Ala Glu Met Phe Phe Arg Lys Lys 
785                 790                 795                 800 


Ser Ile Asn Tyr Asp Glu Lys Lys Lys Arg Glu Gly His His Pro Glu 
                805                 810                 815     


Leu Phe Glu Lys Leu Lys Tyr Pro Ile Leu Lys Asp Lys Arg Tyr Ser 
            820                 825                 830         


Glu Asp Lys Phe Gln Phe His Leu Pro Ile Ser Leu Asn Phe Lys Ser 
        835                 840                 845             


Lys Glu Arg Leu Asn Phe Asn Leu Lys Val Asn Glu Phe Leu Lys Arg 
    850                 855                 860                 


Asn Lys Asp Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
865                 870                 875                 880 


Leu Tyr Leu Val Met Ile Asn Gln Lys Gly Glu Ile Leu Lys Gln Thr 
                885                 890                 895     


Leu Leu Asp Ser Met Gln Ser Gly Lys Gly Arg Pro Glu Ile Asn Tyr 
            900                 905                 910         


Lys Glu Lys Leu Gln Glu Lys Glu Ile Glu Arg Asp Lys Ala Arg Lys 
        915                 920                 925             


Ser Trp Gly Thr Val Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu 
    930                 935                 940                 


Ser Ile Val Ile His Gln Ile Ser Lys Leu Met Val Glu Asn Asn Ala 
945                 950                 955                 960 


Ile Val Val Leu Glu Asp Leu Asn Ile Gly Phe Lys Arg Gly Arg Gln 
                965                 970                 975     


Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp 
            980                 985                 990         


Lys Leu Asn Phe Leu Val Phe Lys  Glu Asn Lys Pro Thr  Glu Pro Gly 
        995                 1000                 1005             


Gly Val  Leu Lys Ala Tyr Gln  Leu Thr Asp Glu Phe  Gln Ser Phe 
    1010                 1015                 1020             


Glu Lys  Leu Ser Lys Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ser 
    1025                 1030                 1035             


Trp Asn  Thr Ser Lys Ile Asp  Pro Arg Thr Gly Phe  Ile Asp Phe 
    1040                 1045                 1050             


Leu His  Pro Ala Tyr Glu Asn  Ile Glu Lys Ala Lys  Gln Trp Ile 
    1055                 1060                 1065             


Asn Lys  Phe Asp Ser Ile Arg  Phe Asn Ser Lys Met  Asp Trp Phe 
    1070                 1075                 1080             


Glu Phe  Thr Ala Asp Thr Arg  Lys Phe Ser Glu Asn  Leu Met Leu 
    1085                 1090                 1095             


Gly Lys  Asn Arg Val Trp Val  Ile Cys Thr Thr Asn  Val Glu Arg 
    1100                 1105                 1110             


Tyr Phe  Thr Ser Lys Thr Ala  Asn Ser Ser Ile Gln  Tyr Asn Ser 
    1115                 1120                 1125             


Ile Gln  Ile Thr Glu Lys Leu  Lys Glu Leu Phe Val  Asp Ile Pro 
    1130                 1135                 1140             


Phe Ser  Asn Gly Gln Asp Leu  Lys Pro Glu Ile Leu  Arg Lys Asn 
    1145                 1150                 1155             


Asp Ala  Val Phe Phe Lys Ser  Leu Leu Phe Tyr Ile  Lys Thr Thr 
    1160                 1165                 1170             


Leu Ser  Leu Arg Gln Asn Asn  Gly Lys Lys Gly Glu  Glu Glu Lys 
    1175                 1180                 1185             


Asp Phe  Ile Leu Ser Pro Val  Val Asp Ser Lys Gly  Arg Phe Phe 
    1190                 1195                 1200             


Asn Ser  Leu Glu Ala Ser Asp  Asp Glu Pro Lys Asp  Ala Asp Ala 
    1205                 1210                 1215             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Leu Met  Asn Leu Leu 
    1220                 1225                 1230             


Val Leu  Asn Glu Thr Lys Glu  Glu Asn Leu Ser Arg  Pro Lys Trp 
    1235                 1240                 1245             


Lys Ile  Lys Asn Lys Asp Trp  Leu Glu Phe Val Trp  Glu Arg Asn 
    1250                 1255                 1260             


Arg 
    


<210>  11
<211>  1373
<212>  PRT
<213>  Moraxella bovoculi

<400>  11

Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Phe Ile Asp Arg Thr Leu Glu His Ile His Ala Lys 
            20                  25                  30          


Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met His Gln Lys Val 
        35                  40                  45              


Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met Met 
    50                  55                  60                  


Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr Leu 
65                  70                  75                  80  


Lys Phe Arg Lys Asn Pro Lys Asp Asp Glu Leu Gln Lys Ala Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ile Val Lys Pro Ile Gly 
            100                 105                 110         


Asn Gly Gly Lys Tyr Lys Ala Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Thr Leu Leu 
                245                 250                 255     


Gly Gly Ile Ser Gly Glu Ala Gly Ser Pro Lys Ile Gln Gly Ile Asn 
            260                 265                 270         


Glu Leu Ile Asn Ser His His Asn Gln His Cys His Lys Ser Glu Arg 
        275                 280                 285             


Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met 
    290                 295                 300                 


Ser Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys 
305                 310                 315                 320 


Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Ala Asp Val Phe Ala Lys 
                325                 330                 335     


Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile 
            340                 345                 350         


Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly 
        355                 360                 365             


Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val 
    370                 375                 380                 


Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn 
385                 390                 395                 400 


Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val 
                405                 410                 415     


His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His Tyr Thr Ala Arg 
            420                 425                 430         


His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys 
        435                 440                 445             


His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn 
    450                 455                 460                 


His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu 
465                 470                 475                 480 


Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln 
                485                 490                 495     


Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His 
            500                 505                 510         


Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly 
        515                 520                 525             


Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile 
    530                 535                 540                 


Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe 
545                 550                 555                 560 


Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn 
                565                 570                 575     


Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln 
            580                 585                 590         


Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys 
        595                 600                 605             


Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Ser Ile Tyr Gln Lys Met 
    610                 615                 620                 


Ile Tyr Lys Tyr Leu Glu Val Arg Lys Gln Phe Pro Lys Val Phe Phe 
625                 630                 635                 640 


Ser Lys Glu Ala Ile Ala Ile Asn Tyr His Pro Ser Lys Glu Leu Val 
                645                 650                 655     


Glu Ile Lys Asp Lys Gly Arg Gln Arg Ser Asp Asp Glu Arg Leu Lys 
            660                 665                 670         


Leu Tyr Arg Phe Ile Leu Glu Cys Leu Lys Ile His Pro Lys Tyr Asp 
        675                 680                 685             


Lys Lys Phe Glu Gly Ala Ile Gly Asp Ile Gln Leu Phe Lys Lys Asp 
    690                 695                 700                 


Lys Lys Gly Arg Glu Val Pro Ile Ser Glu Lys Asp Leu Phe Lys Asp 
705                 710                 715                 720 


Ile Asn Gly Ile Phe Ser Ser Lys Pro Lys Leu Glu Met Glu Asp Phe 
                725                 730                 735     


Phe Ile Gly Glu Phe Lys Arg Tyr Asn Pro Ser Gln Asp Leu Val Asp 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Lys Lys Ile Asp Ser Asn Asp Asn Arg Lys Lys 
        755                 760                 765             


Glu Asn Phe Tyr Asn Asn His Pro Lys Phe Lys Lys Asp Leu Val Arg 
    770                 775                 780                 


Tyr Tyr Tyr Glu Ser Met Cys Lys His Glu Glu Trp Glu Glu Ser Phe 
785                 790                 795                 800 


Glu Phe Ser Lys Lys Leu Gln Asp Ile Gly Cys Tyr Val Asp Val Asn 
                805                 810                 815     


Glu Leu Phe Thr Glu Ile Glu Thr Arg Arg Leu Asn Tyr Lys Ile Ser 
            820                 825                 830         


Phe Cys Asn Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly 
        835                 840                 845             


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala 
    850                 855                 860                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser 
865                 870                 875                 880 


Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln 
                885                 890                 895     


Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His 
            900                 905                 910         


Arg Ala Gly Glu Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys 
        915                 920                 925             


Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Lys 
    930                 935                 940                 


Asp Phe Met Leu His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly 
945                 950                 955                 960 


Met Thr Ile Lys Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln 
                965                 970                 975     


Tyr Asp Glu Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu 
            980                 985                 990         


Leu Tyr Leu Thr Val Ile Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Cys 
        995                 1000                 1005             


Ser Leu  Asn Asp Ile Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Met 
    1010                 1015                 1020             


Thr Thr  Pro Tyr His Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Asn  Ala Arg Val Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu 
    1040                 1045                 1050             


Leu Lys  Ser Gly Tyr Leu Ser  His Val Val His Gln  Ile Ser Gln 
    1055                 1060                 1065             


Leu Met  Leu Lys Tyr Asn Ala  Ile Val Val Leu Glu  Asp Leu Asn 
    1070                 1075                 1080             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr 
    1085                 1090                 1095             


Gln Asn  Phe Glu Asn Ala Leu  Ile Lys Lys Leu Asn  His Leu Val 
    1100                 1105                 1110             


Leu Lys  Asp Lys Ala Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala 
    1115                 1120                 1125             


Leu Gln  Leu Thr Asn Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys 
    1130                 1135                 1140             


Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys 
    1145                 1150                 1155             


Ile Asp  Pro Glu Thr Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr 
    1160                 1165                 1170             


Glu Asn  Ile Gln Ala Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys 
    1175                 1180                 1185             


Ile Cys  Tyr Asn Ala Asp Lys  Asp Tyr Phe Glu Phe  His Ile Asp 
    1190                 1195                 1200             


Tyr Ala  Lys Phe Thr Asp Lys  Ala Lys Asn Ser Arg  Gln Ile Trp 
    1205                 1210                 1215             


Thr Ile  Cys Ser His Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr 
    1220                 1225                 1230             


Ala Asn  Gln Asn Lys Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp 
    1235                 1240                 1245             


Ile Leu  Lys Ser Leu Phe Ala  Arg His His Ile Asn  Glu Lys Gln 
    1250                 1255                 1260             


Pro Asn  Leu Val Met Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe 
    1265                 1270                 1275             


His Lys  Ser Leu Met Tyr Leu  Leu Lys Thr Leu Leu  Ala Leu Arg 
    1280                 1285                 1290             


Tyr Ser  Asn Ala Ser Ser Asp  Glu Asp Phe Ile Leu  Ser Pro Val 
    1295                 1300                 1305             


Ala Asn  Asp Glu Gly Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp 
    1310                 1315                 1320             


Thr Gln  Pro Gln Asn Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1325                 1330                 1335             


Leu Lys  Gly Leu Trp Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp 
    1340                 1345                 1350             


Leu Asn  Lys Val Lys Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn 
    1355                 1360                 1365             


Phe Ala  Gln Asn Arg 
    1370             


<210>  12
<211>  1352
<212>  PRT
<213>  Parcubacteria bacterium

<400>  12

Met Glu Asn Ile Phe Asp Gln Phe Ile Gly Lys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Glu Asp Phe Leu 
            20                  25                  30          


Lys Ile Asn Lys Val Phe Glu Lys Asp Gln Thr Ile Asp Asp Ser Tyr 
        35                  40                  45              


Asn Gln Ala Lys Phe Tyr Phe Asp Ser Leu His Gln Lys Phe Ile Asp 
    50                  55                  60                  


Ala Ala Leu Ala Ser Asp Lys Thr Ser Glu Leu Ser Phe Gln Asn Phe 
65                  70                  75                  80  


Ala Asp Val Leu Glu Lys Gln Asn Lys Ile Ile Leu Asp Lys Lys Arg 
                85                  90                  95      


Glu Met Gly Ala Leu Arg Lys Arg Asp Lys Asn Ala Val Gly Ile Asp 
            100                 105                 110         


Arg Leu Gln Lys Glu Ile Asn Asp Ala Glu Asp Ile Ile Gln Lys Glu 
        115                 120                 125             


Lys Glu Lys Ile Tyr Lys Asp Val Arg Thr Leu Phe Asp Asn Glu Ala 
    130                 135                 140                 


Glu Ser Trp Lys Thr Tyr Tyr Gln Glu Arg Glu Val Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Thr Glu Ser Lys Ala Asp Leu Lys Gln Lys Gly Ala Asp Phe Leu 
                165                 170                 175     


Thr Ala Ala Gly Ile Leu Lys Val Leu Lys Tyr Glu Phe Pro Glu Glu 
            180                 185                 190         


Lys Glu Lys Glu Phe Gln Ala Lys Asn Gln Pro Ser Leu Phe Val Glu 
        195                 200                 205             


Glu Lys Glu Asn Pro Gly Gln Lys Arg Tyr Ile Phe Asp Ser Phe Asp 
    210                 215                 220                 


Lys Phe Ala Gly Tyr Leu Thr Lys Phe Gln Gln Thr Lys Lys Asn Leu 
225                 230                 235                 240 


Tyr Ala Ala Asp Gly Thr Ser Thr Ala Val Ala Thr Arg Ile Ala Asp 
                245                 250                 255     


Asn Phe Ile Ile Phe His Gln Asn Thr Lys Val Phe Arg Asp Lys Tyr 
            260                 265                 270         


Lys Asn Asn His Thr Asp Leu Gly Phe Asp Glu Glu Asn Ile Phe Glu 
        275                 280                 285             


Ile Glu Arg Tyr Lys Asn Cys Leu Leu Gln Arg Glu Ile Glu His Ile 
    290                 295                 300                 


Lys Asn Glu Asn Ser Tyr Asn Lys Ile Ile Gly Arg Ile Asn Lys Lys 
305                 310                 315                 320 


Ile Lys Glu Tyr Arg Asp Gln Lys Ala Lys Asp Thr Lys Leu Thr Lys 
                325                 330                 335     


Ser Asp Phe Pro Phe Phe Lys Asn Leu Asp Lys Gln Ile Leu Gly Glu 
            340                 345                 350         


Val Glu Lys Glu Lys Gln Leu Ile Glu Lys Thr Arg Glu Lys Thr Glu 
        355                 360                 365             


Glu Asp Val Leu Ile Glu Arg Phe Lys Glu Phe Ile Glu Asn Asn Glu 
    370                 375                 380                 


Glu Arg Phe Thr Ala Ala Lys Lys Leu Met Asn Ala Phe Cys Asn Gly 
385                 390                 395                 400 


Glu Phe Glu Ser Glu Tyr Glu Gly Ile Tyr Leu Lys Asn Lys Ala Ile 
                405                 410                 415     


Asn Thr Ile Ser Arg Arg Trp Phe Val Ser Asp Arg Asp Phe Glu Leu 
            420                 425                 430         


Lys Leu Pro Gln Gln Lys Ser Lys Asn Lys Ser Glu Lys Asn Glu Pro 
        435                 440                 445             


Lys Val Lys Lys Phe Ile Ser Ile Ala Glu Ile Lys Asn Ala Val Glu 
    450                 455                 460                 


Glu Leu Asp Gly Asp Ile Phe Lys Ala Val Phe Tyr Asp Lys Lys Ile 
465                 470                 475                 480 


Ile Ala Gln Gly Gly Ser Lys Leu Glu Gln Phe Leu Val Ile Trp Lys 
                485                 490                 495     


Tyr Glu Phe Glu Tyr Leu Phe Arg Asp Ile Glu Arg Glu Asn Gly Glu 
            500                 505                 510         


Lys Leu Leu Gly Tyr Asp Ser Cys Leu Lys Ile Ala Lys Gln Leu Gly 
        515                 520                 525             


Ile Phe Pro Gln Glu Lys Glu Ala Arg Glu Lys Ala Thr Ala Val Ile 
    530                 535                 540                 


Lys Asn Tyr Ala Asp Ala Gly Leu Gly Ile Phe Gln Met Met Lys Tyr 
545                 550                 555                 560 


Phe Ser Leu Asp Asp Lys Asp Arg Lys Asn Thr Pro Gly Gln Leu Ser 
                565                 570                 575     


Thr Asn Phe Tyr Ala Glu Tyr Asp Gly Tyr Tyr Lys Asp Phe Glu Phe 
            580                 585                 590         


Ile Lys Tyr Tyr Asn Glu Phe Arg Asn Phe Ile Thr Lys Lys Pro Phe 
        595                 600                 605             


Asp Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly Ala Leu Leu Lys 
    610                 615                 620                 


Gly Trp Asp Glu Asn Lys Glu Tyr Asp Phe Met Gly Val Ile Leu Lys 
625                 630                 635                 640 


Lys Glu Gly Arg Leu Tyr Leu Gly Ile Met His Lys Asn His Arg Lys 
                645                 650                 655     


Leu Phe Gln Ser Met Gly Asn Ala Lys Gly Asp Asn Ala Asn Arg Tyr 
            660                 665                 670         


Gln Lys Met Ile Tyr Lys Gln Ile Ala Asp Ala Ser Lys Asp Val Pro 
        675                 680                 685             


Arg Leu Leu Leu Thr Ser Lys Lys Ala Met Glu Lys Phe Lys Pro Ser 
    690                 695                 700                 


Gln Glu Ile Leu Arg Ile Lys Lys Glu Lys Thr Phe Lys Arg Glu Ser 
705                 710                 715                 720 


Lys Asn Phe Ser Leu Arg Asp Leu His Ala Leu Ile Glu Tyr Tyr Arg 
                725                 730                 735     


Asn Cys Ile Pro Gln Tyr Ser Asn Trp Ser Phe Tyr Asp Phe Gln Phe 
            740                 745                 750         


Gln Asp Thr Gly Lys Tyr Gln Asn Ile Lys Glu Phe Thr Asp Asp Val 
        755                 760                 765             


Gln Lys Tyr Gly Tyr Lys Ile Ser Phe Arg Asp Ile Asp Asp Glu Tyr 
    770                 775                 780                 


Ile Asn Gln Ala Leu Asn Glu Gly Lys Met Tyr Leu Phe Glu Val Val 
785                 790                 795                 800 


Asn Lys Asp Ile Tyr Asn Thr Lys Asn Gly Ser Lys Asn Leu His Thr 
                805                 810                 815     


Leu Tyr Phe Glu His Ile Leu Ser Ala Glu Asn Leu Asn Asp Pro Val 
            820                 825                 830         


Phe Lys Leu Ser Gly Met Ala Glu Ile Phe Gln Arg Gln Pro Ser Val 
        835                 840                 845             


Asn Glu Arg Glu Lys Ile Thr Thr Gln Lys Asn Gln Cys Ile Leu Asp 
    850                 855                 860                 


Lys Gly Asp Arg Ala Tyr Lys Tyr Arg Arg Tyr Thr Glu Lys Lys Ile 
865                 870                 875                 880 


Met Phe His Met Ser Leu Val Leu Asn Thr Gly Lys Gly Glu Ile Lys 
                885                 890                 895     


Gln Val Gln Phe Asn Lys Ile Ile Asn Gln Arg Ile Ser Ser Ser Asp 
            900                 905                 910         


Asn Glu Met Arg Val Asn Val Ile Gly Ile Asp Arg Gly Glu Lys Asn 
        915                 920                 925             


Leu Leu Tyr Tyr Ser Val Val Lys Gln Asn Gly Glu Ile Ile Glu Gln 
    930                 935                 940                 


Ala Ser Leu Asn Glu Ile Asn Gly Val Asn Tyr Arg Asp Lys Leu Ile 
945                 950                 955                 960 


Glu Arg Glu Lys Glu Arg Leu Lys Asn Arg Gln Ser Trp Lys Pro Val 
                965                 970                 975     


Val Lys Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser His Val Ile His 
            980                 985                 990         


Lys Ile Cys Gln Leu Ile Glu Lys  Tyr Ser Ala Ile Val  Val Leu Glu 
        995                 1000                 1005             


Asp Leu  Asn Met Arg Phe Lys  Gln Ile Arg Gly Gly  Ile Glu Arg 
    1010                 1015                 1020             


Ser Val  Tyr Gln Gln Phe Glu  Lys Ala Leu Ile Asp  Lys Leu Gly 
    1025                 1030                 1035             


Tyr Leu  Val Phe Lys Asp Asn  Arg Asp Leu Arg Ala  Pro Gly Gly 
    1040                 1045                 1050             


Val Leu  Asn Gly Tyr Gln Leu  Ser Ala Pro Phe Val  Ser Phe Glu 
    1055                 1060                 1065             


Lys Met  Arg Lys Gln Thr Gly  Ile Leu Phe Tyr Thr  Gln Ala Glu 
    1070                 1075                 1080             


Tyr Thr  Ser Lys Thr Asp Pro  Ile Thr Gly Phe Arg  Lys Asn Val 
    1085                 1090                 1095             


Tyr Ile  Ser Asn Ser Ala Ser  Leu Asp Lys Ile Lys  Glu Ala Val 
    1100                 1105                 1110             


Lys Lys  Phe Asp Ala Ile Gly  Trp Asp Gly Lys Glu  Gln Ser Tyr 
    1115                 1120                 1125             


Phe Phe  Lys Tyr Asn Pro Tyr  Asn Leu Ala Asp Glu  Lys Tyr Lys 
    1130                 1135                 1140             


Asn Ser  Thr Val Ser Lys Glu  Trp Ala Ile Phe Ala  Ser Ala Pro 
    1145                 1150                 1155             


Arg Ile  Arg Arg Gln Lys Gly  Glu Asp Gly Tyr Trp  Lys Tyr Asp 
    1160                 1165                 1170             


Arg Val  Lys Val Asn Glu Glu  Phe Glu Lys Leu Leu  Lys Val Trp 
    1175                 1180                 1185             


Asn Phe  Val Asn Pro Lys Ala  Thr Asp Ile Lys Gln  Glu Ile Ile 
    1190                 1195                 1200             


Lys Lys  Ile Lys Ala Gly Asp  Leu Gln Gly Glu Lys  Glu Leu Asp 
    1205                 1210                 1215             


Gly Arg  Leu Arg Asn Phe Trp  His Ser Phe Ile Tyr  Leu Phe Asn 
    1220                 1225                 1230             


Leu Val  Leu Glu Leu Arg Asn  Ser Phe Ser Leu Gln  Ile Lys Ile 
    1235                 1240                 1245             


Lys Ala  Gly Glu Val Ile Ala  Val Asp Glu Gly Val  Asp Phe Ile 
    1250                 1255                 1260             


Ala Ser  Pro Val Lys Pro Phe  Phe Thr Thr Pro Asn  Pro Tyr Ile 
    1265                 1270                 1275             


Pro Ser  Asn Leu Cys Trp Leu  Ala Val Glu Asn Ala  Asp Ala Asn 
    1280                 1285                 1290             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Val Met Ile  Leu Lys Lys 
    1295                 1300                 1305             


Ile Arg  Glu His Ala Lys Lys  Asp Pro Glu Phe Lys  Lys Leu Pro 
    1310                 1315                 1320             


Asn Leu  Phe Ile Ser Asn Ala  Glu Trp Asp Glu Ala  Ala Arg Asp 
    1325                 1330                 1335             


Trp Gly  Lys Tyr Ala Gly Thr  Thr Ala Leu Asn Leu  Asp His 
    1340                 1345                 1350         


<210>  13
<211>  1260
<212>  PRT
<213>  Porphyromonas crevioricanis

<400>  13

Met Asp Ser Leu Lys Asp Phe Thr Asn Leu Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu Asn Ile Glu 
            20                  25                  30          


Lys Ala Gly Ile Leu Lys Glu Asp Glu His Arg Ala Glu Ser Tyr Arg 
        35                  40                  45              


Arg Val Lys Lys Ile Ile Asp Thr Tyr His Lys Val Phe Ile Asp Ser 
    50                  55                  60                  


Ser Leu Glu Asn Met Ala Lys Met Gly Ile Glu Asn Glu Ile Lys Ala 
65                  70                  75                  80  


Met Leu Gln Ser Phe Cys Glu Leu Tyr Lys Lys Asp His Arg Thr Glu 
                85                  90                  95      


Gly Glu Asp Lys Ala Leu Asp Lys Ile Arg Ala Val Leu Arg Gly Leu 
            100                 105                 110         


Ile Val Gly Ala Phe Thr Gly Val Cys Gly Arg Arg Glu Asn Thr Val 
        115                 120                 125             


Gln Asn Glu Lys Tyr Glu Ser Leu Phe Lys Glu Lys Leu Ile Lys Glu 
    130                 135                 140                 


Ile Leu Pro Asp Phe Val Leu Ser Thr Glu Ala Glu Ser Leu Pro Phe 
145                 150                 155                 160 


Ser Val Glu Glu Ala Thr Arg Ser Leu Lys Glu Phe Asp Ser Phe Thr 
                165                 170                 175     


Ser Tyr Phe Ala Gly Phe Tyr Glu Asn Arg Lys Asn Ile Tyr Ser Thr 
            180                 185                 190         


Lys Pro Gln Ser Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu 
        195                 200                 205             


Pro Lys Phe Ile Asp Asn Ile Leu Val Phe Gln Lys Ile Lys Glu Pro 
    210                 215                 220                 


Ile Ala Lys Glu Leu Glu His Ile Arg Ala Asp Phe Ser Ala Gly Gly 
225                 230                 235                 240 


Tyr Ile Lys Lys Asp Glu Arg Leu Glu Asp Ile Phe Ser Leu Asn Tyr 
                245                 250                 255     


Tyr Ile His Val Leu Ser Gln Ala Gly Ile Glu Lys Tyr Asn Ala Leu 
            260                 265                 270         


Ile Gly Lys Ile Val Thr Glu Gly Asp Gly Glu Met Lys Gly Leu Asn 
        275                 280                 285             


Glu His Ile Asn Leu Tyr Asn Gln Gln Arg Gly Arg Glu Asp Arg Leu 
    290                 295                 300                 


Pro Leu Phe Arg Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Gln 
305                 310                 315                 320 


Leu Ser Tyr Leu Pro Glu Ser Phe Glu Lys Asp Glu Glu Leu Leu Arg 
                325                 330                 335     


Ala Leu Lys Glu Phe Tyr Asp His Ile Ala Glu Asp Ile Leu Gly Arg 
            340                 345                 350         


Thr Gln Gln Leu Met Thr Ser Ile Ser Glu Tyr Asp Leu Ser Arg Ile 
        355                 360                 365             


Tyr Val Arg Asn Asp Ser Gln Leu Thr Asp Ile Ser Lys Lys Met Leu 
    370                 375                 380                 


Gly Asp Trp Asn Ala Ile Tyr Met Ala Arg Glu Arg Ala Tyr Asp His 
385                 390                 395                 400 


Glu Gln Ala Pro Lys Arg Ile Thr Ala Lys Tyr Glu Arg Asp Arg Ile 
                405                 410                 415     


Lys Ala Leu Lys Gly Glu Glu Ser Ile Ser Leu Ala Asn Leu Asn Ser 
            420                 425                 430         


Cys Ile Ala Phe Leu Asp Asn Val Arg Asp Cys Arg Val Asp Thr Tyr 
        435                 440                 445             


Leu Ser Thr Leu Gly Gln Lys Glu Gly Pro His Gly Leu Ser Asn Leu 
    450                 455                 460                 


Val Glu Asn Val Phe Ala Ser Tyr His Glu Ala Glu Gln Leu Leu Ser 
465                 470                 475                 480 


Phe Pro Tyr Pro Glu Glu Asn Asn Leu Ile Gln Asp Lys Asp Asn Val 
                485                 490                 495     


Val Leu Ile Lys Asn Leu Leu Asp Asn Ile Ser Asp Leu Gln Arg Phe 
            500                 505                 510         


Leu Lys Pro Leu Trp Gly Met Gly Asp Glu Pro Asp Lys Asp Glu Arg 
        515                 520                 525             


Phe Tyr Gly Glu Tyr Asn Tyr Ile Arg Gly Ala Leu Asp Gln Val Ile 
    530                 535                 540                 


Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Arg Lys Pro Tyr Ser 
545                 550                 555                 560 


Thr Arg Lys Val Lys Leu Asn Phe Gly Asn Ser Gln Leu Leu Ser Gly 
                565                 570                 575     


Trp Asp Arg Asn Lys Glu Lys Asp Asn Ser Cys Val Ile Leu Arg Lys 
            580                 585                 590         


Gly Gln Asn Phe Tyr Leu Ala Ile Met Asn Asn Arg His Lys Arg Ser 
        595                 600                 605             


Phe Glu Asn Lys Met Leu Pro Glu Tyr Lys Glu Gly Glu Pro Tyr Phe 
    610                 615                 620                 


Glu Lys Met Asp Tyr Lys Phe Leu Pro Asp Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Leu Ser Lys Lys Gly Ile Glu Ile Tyr Lys Pro Ser Pro 
                645                 650                 655     


Lys Leu Leu Glu Gln Tyr Gly His Gly Thr His Lys Lys Gly Asp Thr 
            660                 665                 670         


Phe Ser Met Asp Asp Leu His Glu Leu Ile Asp Phe Phe Lys His Ser 
        675                 680                 685             


Ile Glu Ala His Glu Asp Trp Lys Gln Phe Gly Phe Lys Phe Ser Asp 
    690                 695                 700                 


Thr Ala Thr Tyr Glu Asn Val Ser Ser Phe Tyr Arg Glu Val Glu Asp 
705                 710                 715                 720 


Gln Gly Tyr Lys Leu Ser Phe Arg Lys Val Ser Glu Ser Tyr Val Tyr 
                725                 730                 735     


Ser Leu Ile Asp Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Cys Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Trp Arg Met Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Ile Tyr Lys 
    770                 775                 780                 


Leu Asp Gly Lys Ala Glu Ile Phe Phe Arg Glu Lys Ser Leu Lys Asn 
785                 790                 795                 800 


Asp His Pro Thr His Pro Ala Gly Lys Pro Ile Lys Lys Lys Ser Arg 
                805                 810                 815     


Gln Lys Lys Gly Glu Glu Ser Leu Phe Glu Tyr Asp Leu Val Lys Asp 
            820                 825                 830         


Arg Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Lys Cys Ser Ala Gly Ser Lys Val Asn Asp Met Val Asn Ala 
    850                 855                 860                 


His Ile Arg Glu Ala Lys Asp Met His Val Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg Asn Leu Leu Tyr Ile Cys Val Ile Asp Ser Arg Gly Thr Ile 
                885                 890                 895     


Leu Asp Gln Ile Ser Leu Asn Thr Ile Asn Asp Ile Asp Tyr His Asp 
            900                 905                 910         


Leu Leu Glu Ser Arg Asp Lys Asp Arg Gln Gln Glu His Arg Asn Trp 
        915                 920                 925             


Gln Thr Ile Glu Gly Ile Lys Glu Leu Lys Gln Gly Tyr Leu Ser Gln 
    930                 935                 940                 


Ala Val His Arg Ile Ala Glu Leu Met Val Ala Tyr Lys Ala Val Val 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Met Gly Phe Lys Arg Gly Arg Gln Lys Val 
                965                 970                 975     


Glu Ser Ser Val Tyr Gln Gln Phe Glu Lys Gln Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Leu Val Asp Lys Lys Lys  Arg Pro Glu Asp Ile  Gly Gly Leu 
        995                 1000                 1005             


Leu Arg  Ala Tyr Gln Phe Thr  Ala Pro Phe Lys Ser  Phe Lys Glu 
    1010                 1015                 1020             


Met Gly  Lys Gln Asn Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1025                 1030                 1035             


Thr Ser  Asn Ile Asp Pro Thr  Thr Gly Phe Val Asn  Leu Phe His 
    1040                 1045                 1050             


Val Gln  Tyr Glu Asn Val Asp  Lys Ala Lys Ser Phe  Phe Gln Lys 
    1055                 1060                 1065             


Phe Asp  Ser Ile Ser Tyr Asn  Pro Lys Lys Asp Trp  Phe Glu Phe 
    1070                 1075                 1080             


Ala Phe  Asp Tyr Lys Asn Phe  Thr Lys Lys Ala Glu  Gly Ser Arg 
    1085                 1090                 1095             


Ser Met  Trp Ile Leu Cys Thr  His Gly Ser Arg Ile  Lys Asn Phe 
    1100                 1105                 1110             


Arg Asn  Ser Gln Lys Asn Gly  Gln Trp Asp Ser Glu  Glu Phe Ala 
    1115                 1120                 1125             


Leu Thr  Glu Ala Phe Lys Ser  Leu Phe Val Arg Tyr  Glu Ile Asp 
    1130                 1135                 1140             


Tyr Thr  Ala Asp Leu Lys Thr  Ala Ile Val Asp Glu  Lys Gln Lys 
    1145                 1150                 1155             


Asp Phe  Phe Val Asp Leu Leu  Lys Leu Phe Lys Leu  Thr Val Gln 
    1160                 1165                 1170             


Met Arg  Asn Ser Trp Lys Glu  Lys Asp Leu Asp Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Pro Val  Ala Gly Ala Asp Gly  Arg Phe Phe Asp Thr  Arg Glu Gly 
    1190                 1195                 1200             


Asn Lys  Ser Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1205                 1210                 1215             


Ile Ala  Leu Lys Gly Leu Trp  Ala Leu Arg Gln Ile  Arg Gln Thr 
    1220                 1225                 1230             


Ser Glu  Gly Gly Lys Leu Lys  Leu Ala Ile Ser Asn  Lys Glu Trp 
    1235                 1240                 1245             


Leu Gln  Phe Val Gln Glu Arg  Ser Tyr Glu Lys Asp  
    1250                 1255                 1260 


<210>  14
<211>  1324
<212>  PRT
<213>  Prevotella disiens

<400>  14

Met Glu Asn Tyr Gln Glu Phe Thr Asn Leu Phe Gln Leu Asn Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Cys Glu Leu Leu Glu 
            20                  25                  30          


Glu Gly Lys Ile Phe Ala Ser Gly Ser Phe Leu Glu Lys Asp Lys Val 
        35                  40                  45              


Arg Ala Asp Asn Val Ser Tyr Val Lys Lys Glu Ile Asp Lys Lys His 
    50                  55                  60                  


Lys Ile Phe Ile Glu Glu Thr Leu Ser Ser Phe Ser Ile Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Lys Gln Tyr Phe Asp Cys Tyr Asn Glu Leu Lys Ala Phe Lys 
                85                  90                  95      


Lys Asp Cys Lys Ser Asp Glu Glu Glu Val Lys Lys Thr Ala Leu Arg 
            100                 105                 110         


Asn Lys Cys Thr Ser Ile Gln Arg Ala Met Arg Glu Ala Ile Ser Gln 
        115                 120                 125             


Ala Phe Leu Lys Ser Pro Gln Lys Lys Leu Leu Ala Ile Lys Asn Leu 
    130                 135                 140                 


Ile Glu Asn Val Phe Lys Ala Asp Glu Asn Val Gln His Phe Ser Glu 
145                 150                 155                 160 


Phe Thr Ser Tyr Phe Ser Gly Phe Glu Thr Asn Arg Glu Asn Phe Tyr 
                165                 170                 175     


Ser Asp Glu Glu Lys Ser Thr Ser Ile Ala Tyr Arg Leu Val His Asp 
            180                 185                 190         


Asn Leu Pro Ile Phe Ile Lys Asn Ile Tyr Ile Phe Glu Lys Leu Lys 
        195                 200                 205             


Glu Gln Phe Asp Ala Lys Thr Leu Ser Glu Ile Phe Glu Asn Tyr Lys 
    210                 215                 220                 


Leu Tyr Val Ala Gly Ser Ser Leu Asp Glu Val Phe Ser Leu Glu Tyr 
225                 230                 235                 240 


Phe Asn Asn Thr Leu Thr Gln Lys Gly Ile Asp Asn Tyr Asn Ala Val 
                245                 250                 255     


Ile Gly Lys Ile Val Lys Glu Asp Lys Gln Glu Ile Gln Gly Leu Asn 
            260                 265                 270         


Glu His Ile Asn Leu Tyr Asn Gln Lys His Lys Asp Arg Arg Leu Pro 
        275                 280                 285             


Phe Phe Ile Ser Leu Lys Lys Gln Ile Leu Ser Asp Arg Glu Ala Leu 
    290                 295                 300                 


Ser Trp Leu Pro Asp Met Phe Lys Asn Asp Ser Glu Val Ile Asp Ala 
305                 310                 315                 320 


Leu Lys Gly Phe Tyr Ile Glu Asp Gly Phe Glu Asn Asn Val Leu Thr 
                325                 330                 335     


Pro Leu Ala Thr Leu Leu Ser Ser Leu Asp Lys Tyr Asn Leu Asn Gly 
            340                 345                 350         


Ile Phe Ile Arg Asn Asn Glu Ala Leu Ser Ser Leu Ser Gln Asn Val 
        355                 360                 365             


Tyr Arg Asn Phe Ser Ile Asp Glu Ala Ile Asp Ala Gln Asn Ala Glu 
    370                 375                 380                 


Leu Gln Thr Phe Asn Asn Tyr Glu Leu Ile Ala Asn Ala Leu Arg Ala 
385                 390                 395                 400 


Lys Ile Lys Lys Glu Thr Lys Gln Gly Arg Lys Ser Phe Glu Lys Tyr 
                405                 410                 415     


Glu Glu Tyr Ile Asp Lys Lys Val Lys Ala Ile Asp Ser Leu Ser Ile 
            420                 425                 430         


Gln Glu Ile Asn Glu Leu Val Glu Asn Tyr Val Ser Glu Phe Asn Ser 
        435                 440                 445             


Asn Ser Gly Asn Met Pro Arg Lys Val Glu Asp Tyr Phe Ser Leu Met 
    450                 455                 460                 


Arg Lys Gly Asp Phe Gly Ser Asn Asp Leu Ile Glu Asn Ile Lys Thr 
465                 470                 475                 480 


Lys Leu Ser Ala Ala Glu Lys Leu Leu Gly Thr Lys Tyr Gln Glu Thr 
                485                 490                 495     


Ala Lys Asp Ile Phe Lys Lys Asp Glu Asn Ser Lys Leu Ile Lys Glu 
            500                 505                 510         


Leu Leu Asp Ala Thr Lys Gln Phe Gln His Phe Ile Lys Pro Leu Leu 
        515                 520                 525             


Gly Thr Gly Glu Glu Ala Asp Arg Asp Leu Val Phe Tyr Gly Asp Phe 
    530                 535                 540                 


Leu Pro Leu Tyr Glu Lys Phe Glu Glu Leu Thr Leu Leu Tyr Asn Lys 
545                 550                 555                 560 


Val Arg Asn Arg Leu Thr Gln Lys Pro Tyr Ser Lys Asp Lys Ile Arg 
                565                 570                 575     


Leu Cys Phe Asn Lys Pro Lys Leu Met Thr Gly Trp Val Asp Ser Lys 
            580                 585                 590         


Thr Glu Lys Ser Asp Asn Gly Thr Gln Tyr Gly Gly Tyr Leu Phe Arg 
        595                 600                 605             


Lys Lys Asn Glu Ile Gly Glu Tyr Asp Tyr Phe Leu Gly Ile Ser Ser 
    610                 615                 620                 


Lys Ala Gln Leu Phe Arg Lys Asn Glu Ala Val Ile Gly Asp Tyr Glu 
625                 630                 635                 640 


Arg Leu Asp Tyr Tyr Gln Pro Lys Ala Asn Thr Ile Tyr Gly Ser Ala 
                645                 650                 655     


Tyr Glu Gly Glu Asn Ser Tyr Lys Glu Asp Lys Lys Arg Leu Asn Lys 
            660                 665                 670         


Val Ile Ile Ala Tyr Ile Glu Gln Ile Lys Gln Thr Asn Ile Lys Lys 
        675                 680                 685             


Ser Ile Ile Glu Ser Ile Ser Lys Tyr Pro Asn Ile Ser Asp Asp Asp 
    690                 695                 700                 


Lys Val Thr Pro Ser Ser Leu Leu Glu Lys Ile Lys Lys Val Ser Ile 
705                 710                 715                 720 


Asp Ser Tyr Asn Gly Ile Leu Ser Phe Lys Ser Phe Gln Ser Val Asn 
                725                 730                 735     


Lys Glu Val Ile Asp Asn Leu Leu Lys Thr Ile Ser Pro Leu Lys Asn 
            740                 745                 750         


Lys Ala Glu Phe Leu Asp Leu Ile Asn Lys Asp Tyr Gln Ile Phe Thr 
        755                 760                 765             


Glu Val Gln Ala Val Ile Asp Glu Ile Cys Lys Gln Lys Thr Phe Ile 
    770                 775                 780                 


Tyr Phe Pro Ile Ser Asn Val Glu Leu Glu Lys Glu Met Gly Asp Lys 
785                 790                 795                 800 


Asp Lys Pro Leu Cys Leu Phe Gln Ile Ser Asn Lys Asp Leu Ser Phe 
                805                 810                 815     


Ala Lys Thr Phe Ser Ala Asn Leu Arg Lys Lys Arg Gly Ala Glu Asn 
            820                 825                 830         


Leu His Thr Met Leu Phe Lys Ala Leu Met Glu Gly Asn Gln Asp Asn 
        835                 840                 845             


Leu Asp Leu Gly Ser Gly Ala Ile Phe Tyr Arg Ala Lys Ser Leu Asp 
    850                 855                 860                 


Gly Asn Lys Pro Thr His Pro Ala Asn Glu Ala Ile Lys Cys Arg Asn 
865                 870                 875                 880 


Val Ala Asn Lys Asp Lys Val Ser Leu Phe Thr Tyr Asp Ile Tyr Lys 
                885                 890                 895     


Asn Arg Arg Tyr Met Glu Asn Lys Phe Leu Phe His Leu Ser Ile Val 
            900                 905                 910         


Gln Asn Tyr Lys Ala Ala Asn Asp Ser Ala Gln Leu Asn Ser Ser Ala 
        915                 920                 925             


Thr Glu Tyr Ile Arg Lys Ala Asp Asp Leu His Ile Ile Gly Ile Asp 
    930                 935                 940                 


Arg Gly Glu Arg Asn Leu Leu Tyr Tyr Ser Val Ile Asp Met Lys Gly 
945                 950                 955                 960 


Asn Ile Val Glu Gln Asp Ser Leu Asn Ile Ile Arg Asn Asn Asp Leu 
                965                 970                 975     


Glu Thr Asp Tyr His Asp Leu Leu Asp Lys Arg Glu Lys Glu Arg Lys 
            980                 985                 990         


Ala Asn Arg Gln Asn Trp Glu Ala  Val Glu Gly Ile Lys  Asp Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Leu Ser Gln Ala  Val His Gln Ile Ala  Gln Leu Met 
    1010                 1015                 1020             


Leu Lys  Tyr Asn Ala Ile Ile  Ala Leu Glu Asp Leu  Gly Gln Met 
    1025                 1030                 1035             


Phe Val  Thr Arg Gly Gln Lys  Ile Glu Lys Ala Val  Tyr Gln Gln 
    1040                 1045                 1050             


Phe Glu  Lys Ser Leu Val Asp  Lys Leu Ser Tyr Leu  Val Asp Lys 
    1055                 1060                 1065             


Lys Arg  Pro Tyr Asn Glu Leu  Gly Gly Ile Leu Lys  Ala Tyr Gln 
    1070                 1075                 1080             


Leu Ala  Ser Ser Ile Thr Lys  Asn Asn Ser Asp Lys  Gln Asn Gly 
    1085                 1090                 1095             


Phe Leu  Phe Tyr Val Pro Ala  Trp Asn Thr Ser Lys  Ile Asp Pro 
    1100                 1105                 1110             


Val Thr  Gly Phe Thr Asp Leu  Leu Arg Pro Lys Ala  Met Thr Ile 
    1115                 1120                 1125             


Lys Glu  Ala Gln Asp Phe Phe  Gly Ala Phe Asp Asn  Ile Ser Tyr 
    1130                 1135                 1140             


Asn Asp  Lys Gly Tyr Phe Glu  Phe Glu Thr Asn Tyr  Asp Lys Phe 
    1145                 1150                 1155             


Lys Ile  Arg Met Lys Ser Ala  Gln Thr Arg Trp Thr  Ile Cys Thr 
    1160                 1165                 1170             


Phe Gly  Asn Arg Ile Lys Arg  Lys Lys Asp Lys Asn  Tyr Trp Asn 
    1175                 1180                 1185             


Tyr Glu  Glu Val Glu Leu Thr  Glu Glu Phe Lys Lys  Leu Phe Lys 
    1190                 1195                 1200             


Asp Ser  Asn Ile Asp Tyr Glu  Asn Cys Asn Leu Lys  Glu Glu Ile 
    1205                 1210                 1215             


Gln Asn  Lys Asp Asn Arg Lys  Phe Phe Asp Asp Leu  Ile Lys Leu 
    1220                 1225                 1230             


Leu Gln  Leu Thr Leu Gln Met  Arg Asn Ser Asp Asp  Lys Gly Asn 
    1235                 1240                 1245             


Asp Tyr  Ile Ile Ser Pro Val  Ala Asn Ala Glu Gly  Gln Phe Phe 
    1250                 1255                 1260             


Asp Ser  Arg Asn Gly Asp Lys  Lys Leu Pro Leu Asp  Ala Asp Ala 
    1265                 1270                 1275             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Gly Leu Trp  Asn Ile Arg 
    1280                 1285                 1290             


Gln Ile  Lys Gln Thr Lys Asn  Lys Asp Asp Leu Asn  Leu Ser Ile 
    1295                 1300                 1305             


Ser Ser  Thr Glu Trp Leu Asp  Phe Val Arg Glu Lys  Pro Tyr Leu 
    1310                 1315                 1320             


Lys 
    


<210>  15
<211>  1484
<212>  PRT
<213>  Peregrinibacteria bacterium


<220>
<221>  misc_feature
<222>  (1073)..(1073)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Ser Asn Phe Phe Lys Asn Phe Thr Asn Leu Tyr Glu Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Asp Thr Leu Thr Asn Met 
            20                  25                  30          


Lys Asp His Leu Glu Tyr Asp Glu Lys Leu Gln Thr Phe Leu Lys Asp 
        35                  40                  45              


Gln Asn Ile Asp Asp Ala Tyr Gln Ala Leu Lys Pro Gln Phe Asp Glu 
    50                  55                  60                  


Ile His Glu Glu Phe Ile Thr Asp Ser Leu Glu Ser Lys Lys Ala Lys 
65                  70                  75                  80  


Glu Ile Asp Phe Ser Glu Tyr Leu Asp Leu Phe Gln Glu Lys Lys Glu 
                85                  90                  95      


Leu Asn Asp Ser Glu Lys Lys Leu Arg Asn Lys Ile Gly Glu Thr Phe 
            100                 105                 110         


Asn Lys Ala Gly Glu Lys Trp Lys Lys Glu Lys Tyr Pro Gln Tyr Glu 
        115                 120                 125             


Trp Lys Lys Gly Ser Lys Ile Ala Asn Gly Ala Asp Ile Leu Ser Cys 
    130                 135                 140                 


Gln Asp Met Leu Gln Phe Ile Lys Tyr Lys Asn Pro Glu Asp Glu Lys 
145                 150                 155                 160 


Ile Lys Asn Tyr Ile Asp Asp Thr Leu Lys Gly Phe Phe Thr Tyr Phe 
                165                 170                 175     


Gly Gly Phe Asn Gln Asn Arg Ala Asn Tyr Tyr Glu Thr Lys Lys Glu 
            180                 185                 190         


Ala Ser Thr Ala Val Ala Thr Arg Ile Val His Glu Asn Leu Pro Lys 
        195                 200                 205             


Phe Cys Asp Asn Val Ile Gln Phe Lys His Ile Ile Lys Arg Lys Lys 
    210                 215                 220                 


Asp Gly Thr Val Glu Lys Thr Glu Arg Lys Thr Glu Tyr Leu Asn Ala 
225                 230                 235                 240 


Tyr Gln Tyr Leu Lys Asn Asn Asn Lys Ile Thr Gln Ile Lys Asp Ala 
                245                 250                 255     


Glu Thr Glu Lys Met Ile Glu Ser Thr Pro Ile Ala Glu Lys Ile Phe 
            260                 265                 270         


Asp Val Tyr Tyr Phe Ser Ser Cys Leu Ser Gln Lys Gln Ile Glu Glu 
        275                 280                 285             


Tyr Asn Arg Ile Ile Gly His Tyr Asn Leu Leu Ile Asn Leu Tyr Asn 
    290                 295                 300                 


Gln Ala Lys Arg Ser Glu Gly Lys His Leu Ser Ala Asn Glu Lys Lys 
305                 310                 315                 320 


Tyr Lys Asp Leu Pro Lys Phe Lys Thr Leu Tyr Lys Gln Ile Gly Cys 
                325                 330                 335     


Gly Lys Lys Lys Asp Leu Phe Tyr Thr Ile Lys Cys Asp Thr Glu Glu 
            340                 345                 350         


Glu Ala Asn Lys Ser Arg Asn Glu Gly Lys Glu Ser His Ser Val Glu 
        355                 360                 365             


Glu Ile Ile Asn Lys Ala Gln Glu Ala Ile Asn Lys Tyr Phe Lys Ser 
    370                 375                 380                 


Asn Asn Asp Cys Glu Asn Ile Asn Thr Val Pro Asp Phe Ile Asn Tyr 
385                 390                 395                 400 


Ile Leu Thr Lys Glu Asn Tyr Glu Gly Val Tyr Trp Ser Lys Ala Ala 
                405                 410                 415     


Met Asn Thr Ile Ser Asp Lys Tyr Phe Ala Asn Tyr His Asp Leu Gln 
            420                 425                 430         


Asp Arg Leu Lys Glu Ala Lys Val Phe Gln Lys Ala Asp Lys Lys Ser 
        435                 440                 445             


Glu Asp Asp Ile Lys Ile Pro Glu Ala Ile Glu Leu Ser Gly Leu Phe 
    450                 455                 460                 


Gly Val Leu Asp Ser Leu Ala Asp Trp Gln Thr Thr Leu Phe Lys Ser 
465                 470                 475                 480 


Ser Ile Leu Ser Asn Glu Lys Leu Lys Ile Ile Thr Asp Ser Gln Thr 
                485                 490                 495     


Pro Ser Glu Ala Leu Leu Lys Met Ile Phe Asn Asp Ile Glu Lys Asn 
            500                 505                 510         


Met Glu Ser Phe Leu Lys Glu Thr Asn Asp Ile Ile Thr Leu Lys Lys 
        515                 520                 525             


Tyr Lys Gly Asn Lys Glu Gly Thr Glu Lys Ile Lys Gln Trp Phe Asp 
    530                 535                 540                 


Tyr Thr Leu Ala Ile Asn Arg Met Leu Lys Tyr Phe Leu Val Lys Glu 
545                 550                 555                 560 


Asn Lys Ile Lys Gly Asn Ser Leu Asp Thr Asn Ile Ser Glu Ala Leu 
                565                 570                 575     


Lys Thr Leu Ile Tyr Ser Asp Asp Ala Glu Trp Phe Lys Trp Tyr Asp 
            580                 585                 590         


Ala Leu Arg Asn Tyr Leu Thr Gln Lys Pro Gln Asp Glu Ala Lys Glu 
        595                 600                 605             


Asn Lys Leu Lys Leu Asn Phe Asp Asn Pro Ser Leu Ala Gly Gly Trp 
    610                 615                 620                 


Asp Val Asn Lys Glu Cys Ser Asn Phe Cys Val Ile Leu Lys Asp Lys 
625                 630                 635                 640 


Asn Glu Lys Lys Tyr Leu Ala Met Ile Lys Lys Gly Glu Asn Thr Leu 
                645                 650                 655     


Phe Gln Lys Glu Trp Thr Glu Gly Arg Gly Lys Asn Leu Thr Lys Lys 
            660                 665                 670         


Ser Asn Pro Leu Phe Glu Ile Asn Asn Cys Glu Ile Leu Ser Lys Met 
        675                 680                 685             


Glu Tyr Asp Phe Trp Ala Asp Val Ser Lys Met Ile Pro Lys Cys Ser 
    690                 695                 700                 


Thr Gln Leu Lys Ala Val Val Asn His Phe Lys Gln Ser Asp Asn Glu 
705                 710                 715                 720 


Phe Ile Phe Pro Ile Gly Tyr Lys Val Thr Ser Gly Glu Lys Phe Arg 
                725                 730                 735     


Glu Glu Cys Lys Ile Ser Lys Gln Asp Phe Glu Leu Asn Asn Lys Val 
            740                 745                 750         


Phe Asn Lys Asn Glu Leu Ser Val Thr Ala Met Arg Tyr Asp Leu Ser 
        755                 760                 765             


Ser Thr Gln Glu Lys Gln Tyr Ile Lys Ala Phe Gln Lys Glu Tyr Trp 
    770                 775                 780                 


Glu Leu Leu Phe Lys Gln Glu Lys Arg Asp Thr Lys Leu Thr Asn Asn 
785                 790                 795                 800 


Glu Ile Phe Asn Glu Trp Ile Asn Phe Cys Asn Lys Lys Tyr Ser Glu 
                805                 810                 815     


Leu Leu Ser Trp Glu Arg Lys Tyr Lys Asp Ala Leu Thr Asn Trp Ile 
            820                 825                 830         


Asn Phe Cys Lys Tyr Phe Leu Ser Lys Tyr Pro Lys Thr Thr Leu Phe 
        835                 840                 845             


Asn Tyr Ser Phe Lys Glu Ser Glu Asn Tyr Asn Ser Leu Asp Glu Phe 
    850                 855                 860                 


Tyr Arg Asp Val Asp Ile Cys Ser Tyr Lys Leu Asn Ile Asn Thr Thr 
865                 870                 875                 880 


Ile Asn Lys Ser Ile Leu Asp Arg Leu Val Glu Glu Gly Lys Leu Tyr 
                885                 890                 895     


Leu Phe Glu Ile Lys Asn Gln Asp Ser Asn Asp Gly Lys Ser Ile Gly 
            900                 905                 910         


His Lys Asn Asn Leu His Thr Ile Tyr Trp Asn Ala Ile Phe Glu Asn 
        915                 920                 925             


Phe Asp Asn Arg Pro Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr Arg 
    930                 935                 940                 


Lys Ala Ile Ser Lys Asp Lys Leu Gly Ile Val Lys Gly Lys Lys Thr 
945                 950                 955                 960 


Lys Asn Gly Thr Trp Ile Ile Lys Asn Tyr Arg Phe Ser Lys Glu Lys 
                965                 970                 975     


Phe Ile Leu His Val Pro Ile Thr Leu Asn Phe Cys Ser Asn Asn Glu 
            980                 985                 990         


Tyr Val Asn Asp Ile Val Asn Thr  Lys Phe Tyr Asn Phe  Ser Asn Leu 
        995                 1000                 1005             


His Phe  Leu Gly Ile Asp Arg  Gly Glu Lys His Leu  Ala Tyr Tyr 
    1010                 1015                 1020             


Ser Leu  Val Asn Lys Asn Gly  Glu Ile Val Asp Gln  Gly Thr Leu 
    1025                 1030                 1035             


Asn Leu  Pro Phe Thr Asp Lys  Asp Gly Asn Gln Arg  Ser Ile Lys 
    1040                 1045                 1050             


Lys Glu  Lys Tyr Phe Tyr Asn  Lys Gln Glu Asp Lys  Trp Glu Ala 
    1055                 1060                 1065             


Lys Glu  Val Asp Xaa Trp Asn  Tyr Asn Asp Leu Leu  Asp Ala Met 
    1070                 1075                 1080             


Ala Ser  Asn Arg Asp Met Ala  Arg Lys Asn Trp Gln  Arg Ile Gly 
    1085                 1090                 1095             


Thr Ile  Lys Glu Ala Lys Asn  Gly Tyr Val Ser Leu  Val Ile Arg 
    1100                 1105                 1110             


Lys Ile  Ala Asp Leu Ala Val  Asn Asn Glu Arg Pro  Ala Phe Ile 
    1115                 1120                 1125             


Val Leu  Glu Asp Leu Asn Thr  Gly Phe Lys Arg Ser  Arg Gln Lys 
    1130                 1135                 1140             


Ile Asp  Lys Ser Val Tyr Gln  Lys Phe Glu Leu Ala  Leu Ala Lys 
    1145                 1150                 1155             


Lys Leu  Asn Phe Leu Val Asp  Lys Asn Ala Lys Arg  Asp Glu Ile 
    1160                 1165                 1170             


Gly Ser  Pro Thr Lys Ala Leu  Gln Leu Thr Pro Pro  Val Asn Asn 
    1175                 1180                 1185             


Tyr Gly  Asp Ile Glu Asn Lys  Lys Gln Ala Gly Ile  Met Leu Tyr 
    1190                 1195                 1200             


Thr Arg  Ala Asn Tyr Thr Ser  Gln Thr Asp Pro Ala  Thr Gly Trp 
    1205                 1210                 1215             


Arg Lys  Thr Ile Tyr Leu Lys  Ala Gly Pro Glu Glu  Thr Thr Tyr 
    1220                 1225                 1230             


Lys Lys  Asp Gly Lys Ile Lys  Asn Lys Ser Val Lys  Asp Gln Ile 
    1235                 1240                 1245             


Ile Glu  Thr Phe Thr Asp Ile  Gly Phe Asp Gly Lys  Asp Tyr Tyr 
    1250                 1255                 1260             


Phe Glu  Tyr Asp Lys Gly Glu  Phe Val Asp Glu Lys  Thr Gly Glu 
    1265                 1270                 1275             


Ile Lys  Pro Lys Lys Trp Arg  Leu Tyr Ser Gly Glu  Asn Gly Lys 
    1280                 1285                 1290             


Ser Leu  Asp Arg Phe Arg Gly  Glu Arg Glu Lys Asp  Lys Tyr Glu 
    1295                 1300                 1305             


Trp Lys  Ile Asp Lys Ile Asp  Ile Val Lys Ile Leu  Asp Asp Leu 
    1310                 1315                 1320             


Phe Val  Asn Phe Asp Lys Asn  Ile Ser Leu Leu Lys  Gln Leu Lys 
    1325                 1330                 1335             


Glu Gly  Val Glu Leu Thr Arg  Asn Asn Glu His Gly  Thr Gly Glu 
    1340                 1345                 1350             


Ser Leu  Arg Phe Ala Ile Asn  Leu Ile Gln Gln Ile  Arg Asn Thr 
    1355                 1360                 1365             


Gly Asn  Asn Glu Arg Asp Asn  Asp Phe Ile Leu Ser  Pro Val Arg 
    1370                 1375                 1380             


Asp Glu  Asn Gly Lys His Phe  Asp Ser Arg Glu Tyr  Trp Asp Lys 
    1385                 1390                 1395             


Glu Thr  Lys Gly Glu Lys Ile  Ser Met Pro Ser Ser  Gly Asp Ala 
    1400                 1405                 1410             


Asn Gly  Ala Phe Asn Ile Ala  Arg Lys Gly Ile Ile  Met Asn Ala 
    1415                 1420                 1425             


His Ile  Leu Ala Asn Ser Asp  Ser Lys Asp Leu Ser  Leu Phe Val 
    1430                 1435                 1440             


Ser Asp  Glu Glu Trp Asp Leu  His Leu Asn Asn Lys  Thr Glu Trp 
    1445                 1450                 1455             


Lys Lys  Gln Leu Asn Ile Phe  Ser Ser Arg Lys Ala  Met Ala Lys 
    1460                 1465                 1470             


Arg Lys  Lys Lys Arg Pro Ala  Ala Thr Lys Lys 
    1475                 1480                 


<210>  16
<211>  1245
<212>  PRT
<213>  Porphyromonas macacae

<400>  16

Met Lys Thr Gln His Phe Phe Glu Asp Phe Thr Ser Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Ile Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Ile Lys Lys Asn Gly Leu Ile Arg Arg Asp Glu Gln Arg Leu Asp 
        35                  40                  45              


Asp Tyr Glu Lys Leu Lys Lys Val Ile Asp Glu Tyr His Glu Asp Phe 
    50                  55                  60                  


Ile Ala Asn Ile Leu Ser Ser Phe Ser Phe Ser Glu Glu Ile Leu Gln 
65                  70                  75                  80  


Ser Tyr Ile Gln Asn Leu Ser Ile Ser Glu Ala Arg Ala Lys Ile Glu 
                85                  90                  95      


Lys Thr Met Arg Asp Thr Leu Ala Lys Ala Phe Ser Glu Asp Glu Arg 
            100                 105                 110         


Tyr Lys Ser Ile Phe Lys Lys Glu Leu Val Lys Lys Asp Ile Pro Val 
        115                 120                 125             


Trp Cys Pro Ala Tyr Lys Ser Leu Cys Lys Lys Phe Asp Asn Phe Thr 
    130                 135                 140                 


Thr Ser Leu Val Pro Phe His Glu Asn Arg Lys Asn Leu Tyr Thr Ser 
145                 150                 155                 160 


Asn Glu Ile Thr Ala Ser Ile Pro Tyr Arg Ile Val His Val Asn Leu 
                165                 170                 175     


Pro Lys Phe Ile Gln Asn Ile Glu Ala Leu Cys Glu Leu Gln Lys Lys 
            180                 185                 190         


Met Gly Ala Asp Leu Tyr Leu Glu Met Met Glu Asn Leu Arg Asn Val 
        195                 200                 205             


Trp Pro Ser Phe Val Lys Thr Pro Asp Asp Leu Cys Asn Leu Lys Thr 
    210                 215                 220                 


Tyr Asn His Leu Met Val Gln Ser Ser Ile Ser Glu Tyr Asn Arg Phe 
225                 230                 235                 240 


Val Gly Gly Tyr Ser Thr Glu Asp Gly Thr Lys His Gln Gly Ile Asn 
                245                 250                 255     


Glu Trp Ile Asn Ile Tyr Arg Gln Arg Asn Lys Glu Met Arg Leu Pro 
            260                 265                 270         


Gly Leu Val Phe Leu His Lys Gln Ile Leu Ala Lys Val Asp Ser Ser 
        275                 280                 285             


Ser Phe Ile Ser Asp Thr Leu Glu Asn Asp Asp Gln Val Phe Cys Val 
    290                 295                 300                 


Leu Arg Gln Phe Arg Lys Leu Phe Trp Asn Thr Val Ser Ser Lys Glu 
305                 310                 315                 320 


Asp Asp Ala Ala Ser Leu Lys Asp Leu Phe Cys Gly Leu Ser Gly Tyr 
                325                 330                 335     


Asp Pro Glu Ala Ile Tyr Val Ser Asp Ala His Leu Ala Thr Ile Ser 
            340                 345                 350         


Lys Asn Ile Phe Asp Arg Trp Asn Tyr Ile Ser Asp Ala Ile Arg Arg 
        355                 360                 365             


Lys Thr Glu Val Leu Met Pro Arg Lys Lys Glu Ser Val Glu Arg Tyr 
    370                 375                 380                 


Ala Glu Lys Ile Ser Lys Gln Ile Lys Lys Arg Gln Ser Tyr Ser Leu 
385                 390                 395                 400 


Ala Glu Leu Asp Asp Leu Leu Ala His Tyr Ser Glu Glu Ser Leu Pro 
                405                 410                 415     


Ala Gly Phe Ser Leu Leu Ser Tyr Phe Thr Ser Leu Gly Gly Gln Lys 
            420                 425                 430         


Tyr Leu Val Ser Asp Gly Glu Val Ile Leu Tyr Glu Glu Gly Ser Asn 
        435                 440                 445             


Ile Trp Asp Glu Val Leu Ile Ala Phe Arg Asp Leu Gln Val Ile Leu 
    450                 455                 460                 


Asp Lys Asp Phe Thr Glu Lys Lys Leu Gly Lys Asp Glu Glu Ala Val 
465                 470                 475                 480 


Ser Val Ile Lys Lys Ala Leu Asp Ser Ala Leu Arg Leu Arg Lys Phe 
                485                 490                 495     


Phe Asp Leu Leu Ser Gly Thr Gly Ala Glu Ile Arg Arg Asp Ser Ser 
            500                 505                 510         


Phe Tyr Ala Leu Tyr Thr Asp Arg Met Asp Lys Leu Lys Gly Leu Leu 
        515                 520                 525             


Lys Met Tyr Asp Lys Val Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser 
    530                 535                 540                 


Ile Glu Lys Phe Lys Leu His Phe Asp Asn Pro Ser Leu Leu Ser Gly 
545                 550                 555                 560 


Trp Asp Lys Asn Lys Glu Leu Asn Asn Leu Ser Val Ile Phe Arg Gln 
                565                 570                 575     


Asn Gly Tyr Tyr Tyr Leu Gly Ile Met Thr Pro Lys Gly Lys Asn Leu 
            580                 585                 590         


Phe Lys Thr Leu Pro Lys Leu Gly Ala Glu Glu Met Phe Tyr Glu Lys 
        595                 600                 605             


Met Glu Tyr Lys Gln Ile Ala Glu Pro Met Leu Met Leu Pro Lys Val 
    610                 615                 620                 


Phe Phe Pro Lys Lys Thr Lys Pro Ala Phe Ala Pro Asp Gln Ser Val 
625                 630                 635                 640 


Val Asp Ile Tyr Asn Lys Lys Thr Phe Lys Thr Gly Gln Lys Gly Phe 
                645                 650                 655     


Asn Lys Lys Asp Leu Tyr Arg Leu Ile Asp Phe Tyr Lys Glu Ala Leu 
            660                 665                 670         


Thr Val His Glu Trp Lys Leu Phe Asn Phe Ser Phe Ser Pro Thr Glu 
        675                 680                 685             


Gln Tyr Arg Asn Ile Gly Glu Phe Phe Asp Glu Val Arg Glu Gln Ala 
    690                 695                 700                 


Tyr Lys Val Ser Met Val Asn Val Pro Ala Ser Tyr Ile Asp Glu Ala 
705                 710                 715                 720 


Val Glu Asn Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ser Pro Tyr Ser Lys Gly Ile Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Ala Leu Phe Ser Glu Gln Asn Gln Ser Arg Val Tyr Lys Leu Cys Gly 
        755                 760                 765             


Gly Gly Glu Leu Phe Tyr Arg Lys Ala Ser Leu His Met Gln Asp Thr 
    770                 775                 780                 


Thr Val His Pro Lys Gly Ile Ser Ile His Lys Lys Asn Leu Asn Lys 
785                 790                 795                 800 


Lys Gly Glu Thr Ser Leu Phe Asn Tyr Asp Leu Val Lys Asp Lys Arg 
                805                 810                 815     


Phe Thr Glu Asp Lys Phe Phe Phe His Val Pro Ile Ser Ile Asn Tyr 
            820                 825                 830         


Lys Asn Lys Lys Ile Thr Asn Val Asn Gln Met Val Arg Asp Tyr Ile 
        835                 840                 845             


Ala Gln Asn Asp Asp Leu Gln His Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Ile Ser Arg Ile Asp Thr Arg Gly Asn Leu Leu Glu Gln 
865                 870                 875                 880 


Phe Ser Leu Asn Val Ile Glu Ser Asp Lys Gly Asp Leu Arg Thr Asp 
                885                 890                 895     


Tyr Gln Lys Ile Leu Gly Asp Arg Glu Gln Glu Arg Leu Arg Arg Arg 
            900                 905                 910         


Gln Glu Trp Lys Ser Ile Glu Ser Ile Lys Asp Leu Lys Asp Gly Tyr 
        915                 920                 925             


Met Ser Gln Val Val His Lys Ile Cys Asn Met Val Val Glu His Lys 
    930                 935                 940                 


Ala Ile Val Val Leu Glu Asn Leu Asn Leu Ser Phe Met Lys Gly Arg 
945                 950                 955                 960 


Lys Lys Val Glu Lys Ser Val Tyr Glu Lys Phe Glu Arg Met Leu Val 
                965                 970                 975     


Asp Lys Leu Asn Tyr Leu Val Val Asp Lys Lys Asn Leu Ser Asn Glu 
            980                 985                 990         


Pro Gly Gly Leu Tyr Ala Ala Tyr  Gln Leu Thr Asn Pro  Leu Phe Ser 
        995                 1000                 1005             


Phe Glu  Glu Leu His Arg Tyr  Pro Gln Ser Gly Ile  Leu Phe Phe 
    1010                 1015                 1020             


Val Asp  Pro Trp Asn Thr Ser  Leu Thr Asp Pro Ser  Thr Gly Phe 
    1025                 1030                 1035             


Val Asn  Leu Leu Gly Arg Ile  Asn Tyr Thr Asn Val  Gly Asp Ala 
    1040                 1045                 1050             


Arg Lys  Phe Phe Asp Arg Phe  Asn Ala Ile Arg Tyr  Asp Gly Lys 
    1055                 1060                 1065             


Gly Asn  Ile Leu Phe Asp Leu  Asp Leu Ser Arg Phe  Asp Val Arg 
    1070                 1075                 1080             


Val Glu  Thr Gln Arg Lys Leu  Trp Thr Leu Thr Thr  Phe Gly Ser 
    1085                 1090                 1095             


Arg Ile  Ala Lys Ser Lys Lys  Ser Gly Lys Trp Met  Val Glu Arg 
    1100                 1105                 1110             


Ile Glu  Asn Leu Ser Leu Cys  Phe Leu Glu Leu Phe  Glu Gln Phe 
    1115                 1120                 1125             


Asn Ile  Gly Tyr Arg Val Glu  Lys Asp Leu Lys Lys  Ala Ile Leu 
    1130                 1135                 1140             


Ser Gln  Asp Arg Lys Glu Phe  Tyr Val Arg Leu Ile  Tyr Leu Phe 
    1145                 1150                 1155             


Asn Leu  Met Met Gln Ile Arg  Asn Ser Asp Gly Glu  Glu Asp Tyr 
    1160                 1165                 1170             


Ile Leu  Ser Pro Ala Leu Asn  Glu Lys Asn Leu Gln  Phe Asp Ser 
    1175                 1180                 1185             


Arg Leu  Ile Glu Ala Lys Asp  Leu Pro Val Asp Ala  Asp Ala Asn 
    1190                 1195                 1200             


Gly Ala  Tyr Asn Val Ala Arg  Lys Gly Leu Met Val  Val Gln Arg 
    1205                 1210                 1215             


Ile Lys  Arg Gly Asp His Glu  Ser Ile His Arg Ile  Gly Arg Ala 
    1220                 1225                 1230             


Gln Trp  Leu Arg Tyr Val Gln  Glu Gly Ile Val Glu  
    1235                 1240                 1245 


<210>  17
<211>  1250
<212>  PRT
<213>  Smithella sp.

<400>  17

Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Lys Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Thr Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Met 
            340                 345                 350         


Tyr Phe Arg Ser Gly Ala Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Ser Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Ala Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Cys Pro Glu Asn Glu Lys Leu Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Asp Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Phe Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Ala Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Val Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Ile Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Ala Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Asn Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asp  Phe Lys Asn Phe Thr  Glu Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Gln Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Ser Ala Asp Phe  Phe Lys Ala Leu Met  Lys Asn Leu 
    1145                 1150                 1155             


Ser Ile  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Asp 
    1160                 1165                 1170             


Asn Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Lys Gly 
    1175                 1180                 1185             


Arg Phe  Phe Asp Ser Arg Lys  Ala Asp Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Val  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210>  18
<211>  3987
<212>  DNA
<213>  Artificial

<220>
<223>  enAsCpf1

<400>  18
atggccggga gcaagaagcg ccggataaag caggacacgc agttcgaggg cttcaccaac       60

ctgtaccaag tctccaagac gctccggttc gagcttatcc cgcaagggaa gaccctgaaa      120

cacatccagg aacaaggttt catcgaggag gacaaggccc gcaacgacca ctacaaggag      180

ctcaagccca taatcgatcg gatctacaag acgtacgccg accagtgcct ccaactggtg      240

cagctcgact gggagaacct gagcgccgcc attgacagct accgcaagga aaagacggag      300

gagacgcgca acgcccttat tgaggagcaa gccacctacc gcaacgccat ccacgactac      360

ttcatcgggc gcaccgacaa cctgacggac gcgatcaaca agcgccacgc ggaaatctac      420

aagggccttt tcaaggccga gctcttcaac gggaaggtcc taaaacagct cgggactgtc      480

acgacaaccg agcatgagaa cgccctcctt cgcagcttcg acaagttcac cacatacttc      540

tcgggcttct accggaaccg caagaacgtt ttcagcgccg aggacatctc caccgccatc      600

ccgcacagga tcgtccagga caacttcccc aagttcaagg agaactgcca catcttcacg      660

cgcctgatta cagccgtacc ttcacttcgt gagcacttcg agaacgtcaa aaaggccatc      720

gggatcttcg tctccacgtc catcgaggag gtattctctt tcccgttcta taaccagctc      780

ctgacccaga cgcagatcga cctctacaac cagctactgg gcggcatcag ccgggaggcc      840

gggaccgaga aaataaaggg cctcaacgaa gttctcaacc tggccatcca gaagaacgac      900

gagaccgcgc atatcatcgc atccctgccg catcgcttca ttcctttgtt caagcagata      960

ttgagcgacc ggaacaccct ctcgttcatc ctcgaagaat tcaagagcga cgaggaggtc     1020

attcagtctt tctgcaagta caagacgctc ctacggaatg agaatgtgct ggagaccgcg     1080

gaggcactct tcaatgagct gaactccatt gacctgaccc acatcttcat tagccacaag     1140

aaactggaga cgatctccag cgccctgtgc gaccactggg acactctccg caacgccctc     1200

tacgaacgcc ggatctccga acttaccggc aagataacta agtcggctaa ggagaaggtg     1260

caacggagcc tcaagcacga ggacatcaac cttcaggaaa tcatctcagc cgcgggcaag     1320

gagctgagcg aggcgtttaa gcagaaaaca tcggagatac tgagccacgc gcacgcggcc     1380

ctggatcaac cgctgccgac gactctcaag aagcaagagg agaaggaaat ccttaagtcc     1440

cagctcgact cgctgctcgg cctctatcac ttgctcgact ggttcgcggt tgatgagtcc     1500

aacgaggtgg acccggagtt ctccgcgcgc ctcacgggta ttaagctgga gatggagcca     1560

agcttaagct tctacaacaa ggcccgcaac tacgcgacca aaaaaccgta ctcagtcgag     1620

aaattcaagc tgaatttcca gatgcctaca ttggcgaggg ggtgggacgt gaaccgcgag     1680

aagaacaatg gagccatcct gttcgtcaaa aatgggttgt actacctggg catcatgccc     1740

aagcagaagg gccgttacaa ggccctgtca ttcgagccta ccgagaagac ctcggagggc     1800

ttcgacaaga tgtactacga ctatttcccg gacgccgcca agatgatccc gaagtgctcc     1860

acgcagctca aagccgtcac ggcccacttc cagacgcata ccacgccgat acttctgagc     1920

aacaacttca ttgagccgct agagatcacg aaggagatat acgacctaaa caaccccgaa     1980

aaggagccca agaagttcca gacagcctac gctaagaaga caggtgatca gaagggatat     2040

agggaggcac tctgcaagtg gatcgacttc acgcgcgact tcctgtcgaa atatacaaag     2100

acgaccagca ttgacctaag ttctctccgc ccatcctccc agtacaagga tctgggcgag     2160

tattatgcgg agctgaaccc attgctgtac cacatcagct tccagaggat cgccgagaag     2220

gagattatgg acgcggtgga gacggggaaa ctatacctgt tccaaatata taacaaggac     2280

ttcgctaaag ggcaccacgg gaagcccaac ctgcacacac tctactggac gggcttgttt     2340

tcgccagaaa atttggccaa gacttcgatc aagctcaacg gccaggcgga gttgttttac     2400

cgtcccaagt ctcgcatgaa gcgcatggcg catcgcctcg gagagaaaat gcttaacaag     2460

aagctcaagg atcagaagac gcccatacct gatacgttgt accaggaatt gtacgactac     2520

gtgaaccacc gcctatcgca cgacctctca gacgaggccc gcgccctcct cccaaacgtg     2580

attactaagg aggtttccca tgaaataatc aaggaccgac ggttcaccag cgacaaattt     2640

tttttccacg tgcctatcac gctcaattac caggcggcca actccccatc gaagttcaac     2700

cagcgcgtga acgcctacct taaggagcac ccggagaccc caatcatcgg gatcgaccgt     2760

ggcgagcgga acctgatcta tattacggtg atcgatagca ccgggaagat cctggagcag     2820

cgctccctga acacaatcca gcagtttgac taccagaaga aactcgacaa ccgggagaag     2880

gagcgcgtcg cagcccggca agcatggagt gtggtcggca ccataaagga cctgaaacag     2940

ggttacctaa gtcaagttat ccacgagatc gttgacctga tgatacacta tcaagccgta     3000

gtcgtgctgg agaacctcaa cttcgggttt aagtccaagc gcaccggcat cgcggagaag     3060

gcggtgtacc agcagttcga gaagatgctg atcgacaagc tgaactgcct ggtgctcaag     3120

gactaccctg cggagaaggt cggcggggtc ttgaacccgt accagctaac cgaccagttc     3180

acgagcttcg ccaaaatggg cacgcagtcc ggattcttgt tttatgtccc ggctccatat     3240

acaagtaaga tcgacccgct gacagggttt gttgacccat tcgtgtggaa gaccatcaag     3300

aaccacgaga gcaggaaaca cttcttagag ggcttcgact tcctgcatta cgacgttaag     3360

acaggcgact tcatcctgca cttcaagatg aaccgcaacc tgtcgttcca gaggggcctg     3420

cccggcttca tgcccgcctg ggatatcgtc tttgagaaga atgagacgca gttcgacgcg     3480

aaggggacgc cgttcatcgc tggaaagcgg atcgtgccgg tcatcgagaa ccaccgcttc     3540

acgggtcgct accgagattt ataccccgcc aacgaactaa ttgcgctgct ggaggagaag     3600

gggatcgtgt tccgagatgg cagcaacatt ctcccgaagc tgctggagaa cgacgactcg     3660

cacgctattg acacgatggt cgccctcata cggagcgtgc ttcagatgcg gaacagtaac     3720

gctgccacgg gcgaggacta cattaactcc cccgtccgcg acctcaacgg ggtctgcttc     3780

gatagccgct tccagaaccc ggagtggcct atggatgcgg acgcgaacgg ggcctaccac     3840

atcgccctca agggccaact cctgctcaac cacttgaagg aaagcaaaga cctcaaattg     3900

cagaatggca tcagtaacca ggactggctc gcgtacatcc aggaactgag aaacgggtcc     3960

aagaagcggc gtatcaagca agattga                                         3987


<210>  19
<211>  3987
<212>  DNA
<213>  Artificial

<220>
<223>  enAsCpf1

<400>  19
atggcgggaa gcaaaaagcg ccggattaag caagacacgc agttcgaggg cttcacgaac       60

ctctaccaag tcagcaagac cctccggttc gagctgatac cacagggaaa gacgctcaag      120

cacatccagg aacagggctt catcgaggag gacaaggcgc gcaacgacca ctacaaggag      180

ttgaaaccga tcatcgaccg catctacaag acgtacgccg accagtgcct ccagctcgtg      240

cagctcgact gggagaacct ctccgccgcc attgactcgt accggaagga gaagactgag      300

gagacccgca acgccctgat cgaggagcaa gcaacctacc ggaacgccat ccacgactac      360

ttcatcggcc gcaccgacaa cctcaccgac gcgatcaaca agcggcacgc ggagatatac      420

aaagggctgt tcaaggcgga gctgttcaac ggcaaggtgc tcaagcagct agggacggtg      480

accacgaccg agcacgagaa cgcgctcctc cgcagcttcg acaagttcac cacctacttc      540

agcggcttct accggaaccg caagaatgtg ttcagcgcgg aggacatcag cacggccatc      600

ccgcaccgca tcgtccagga caacttcccg aagttcaagg agaactgcca catcttcacc      660

cgcctgataa ccgccgtccc ctccctgcgg gagcacttcg agaacgtcaa aaaggcaatt      720

gggatcttcg tctcgaccag cattgaggag gtgttcagct tccccttcta caaccagctc      780

ctcacccaga cgcagatcga cctgtacaat cagttgctcg gcgggataag ccgcgaggcg      840

ggaaccgaaa aaatcaaggg gctgaacgaa gtgttgaacc tcgccatcca gaagaacgac      900

gagaccgcgc acatcatcgc ctccctgccc caccggttca tcccgctgtt caagcagatc      960

ctctctgacc ggaacaccct gtccttcatt cttgaggagt tcaagtcgga cgaggaggtc     1020

atccagagct tctgcaagta caagacgctg ctacggaacg agaacgtgct ggagacggcg     1080

gaggcactgt tcaacgagct aaacagcatc gacctcacgc acatcttcat cagtcacaag     1140

aaactggaga ccatctcctc cgcgctgtgc gaccactggg acacgctcag gaacgcgctc     1200

tacgagcgcc gaatcagtga gctgacgggc aagatcacga agtccgcgaa ggagaaggtg     1260

cagcggtccc tcaagcacga ggacatcaac ctccaggaga tcatctcagc ggctgggaaa     1320

gagctgtccg aggcgttcaa gcagaaaacg agcgaaatcc tgtcccacgc gcacgcggcc     1380

ctggatcagc ctctgccgac gaccctcaag aaacaagaag aaaaggaaat cctcaagtcg     1440

cagctcgact cgctgctggg cctgtaccat ctcctcgact ggttcgccgt ggacgagagc     1500

aacgaggtgg accccgagtt ctccgcgcgg cttacgggga tcaagctgga gatggagccc     1560

agcctgtcct tctacaacaa ggcgcgcaac tacgccacca agaagcccta cagcgtggag     1620

aagttcaagc tcaacttcca gatgcccact ctcgcacgtg ggtgggacgt caaccgcgaa     1680

aaaaataatg gggcgatcct gttcgtcaag aacggcctgt actacttggg catcatgccg     1740

aaacagaagg gccgctacaa ggccctgagc ttcgaaccga ccgagaaaac gagcgagggg     1800

ttcgacaaga tgtactacga ctacttcccc gacgccgcga agatgattcc aaagtgctcc     1860

acgcagctta aggccgtgac ggcccacttc cagacgcaca cgaccccgat cctcctcagc     1920

aacaacttca tcgagcccct ggagatcacg aaggagatat acgacctgaa caacccggag     1980

aaggagccca agaaattcca gaccgcctac gccaagaaga caggcgacca aaagggttac     2040

agggaggccc tctgcaagtg gatcgacttc actagggact tcctgtccaa gtacaccaag     2100

actacctcta tcgacctgtc cagcctccgc ccgtcgtccc agtacaaaga tttgggcgag     2160

tattacgcgg agctgaaccc actgctctac cacatcagct tccagcgcat cgcggagaag     2220

gagatcatgg acgcagtgga gacgggcaag ctatacctat ttcagatata caacaaagac     2280

ttcgctaagg gacaccacgg caagcctaac ctgcacaccc tctactggac ggggctcttc     2340

agcccggaga acctcgccaa gacctcgatc aagctcaacg gccaggccga gctgttctac     2400

cggcccaagt cccgcatgaa gcggatggcc caccggctcg gggagaaaat gctcaacaag     2460

aaattgaagg accaaaaaac gccgataccc gacaccctat accaggagct gtacgactat     2520

gtgaaccacc gcctgagcca cgacctcagc gacgaggcgc gggccctcct gccgaacgtc     2580

atcacaaagg aggtcagcca cgagatcatc aaggaccggc gcttcacctc cgacaagttt     2640

ttctttcacg tgcccatcac gctcaactac caggccgcca actcgccgtc caagttcaac     2700

cagcgcgtga acgcctacct caaggagcac cccgagaccc cgatcatcgg gattgaccga     2760

ggggagcgga acctcatcta catcaccgtc atcgacagca ccgggaagat ccttgaacag     2820

cggtcgctca acaccatcca gcagttcgac taccagaaga aactcgacaa ccgggagaag     2880

gagagagtgg cggcccgcca ggcttggtcc gtcgtcggga cgattaagga cttgaaacaa     2940

ggttacctgt cgcaagtgat ccacgagatc gttgacctga tgatccacta ccaagccgtc     3000

gtggtcctgg agaacctcaa cttcggcttc aagagcaaac gaaccggcat cgcggagaag     3060

gccgtgtacc agcagttcga aaaaatgctg atcgacaagc tgaactgcct cgtgctcaag     3120

gactaccccg ctgagaaggt cggcggggtg ctgaacccgt accagctcac tgaccagttc     3180

accagcttcg caaagatggg cacccagtcc ggcttcctgt tctacgtgcc tgcgccatac     3240

acctcgaaga tcgacccgct caccgggttc gtggacccct tcgtctggaa gaccatcaag     3300

aaccacgaga gccgcaagca cttcctggag ggcttcgact tcctccacta cgacgtcaag     3360

accggggact tcatcctgca cttcaagatg aaccgcaacc tcagtttcca gcgcggcctg     3420

ccggggttca tgcccgcttg ggatatagtc ttcgagaaga atgagacgca gttcgacgcg     3480

aagggcaccc cgttcatcgc cgggaagcgc atcgtgccgg tcatcgagaa ccaccggttc     3540

accgggcgct accgcgacct atacccggcg aacgagttga tcgccctcct ggaggagaag     3600

ggcatcgtgt tccgcgacgg ctccaacatc ctcccgaagc tgctcgaaaa cgacgactcc     3660

cacgccatcg acacgatggt cgcgctgatc cggtcggtgc tccagatgcg gaactccaac     3720

gccgcgacgg gcgaggacta catcaacagt ccggtccgcg atctgaacgg cgtctgcttc     3780

gactcccggt tccagaaccc cgagtggccg atggacgcgg acgcgaacgg cgcataccac     3840

atcgccctaa aagggcaatt gctgctcaac cacctcaagg aatccaaaga cctaaagctc     3900

cagaacggca tctccaacca ggactggctg gcgtacatcc aggaactgcg gaacgggagc     3960

aaaaaacgtc ggatcaagca agattga                                         3987


<210>  20
<211>  3987
<212>  DNA
<213>  Artificial

<220>
<223>  enAsCpf1

<400>  20
atggcgggct ccaagaaacg ccggattaag caagataccc agttcgaggg gttcacgaac       60

ctctaccaag tgagcaagac cctccgattc gaactgattc ctcaggggaa gaccctcaag      120

cacatccagg agcaagggtt catcgaggag gacaaggcgc ggaacgacca ctacaaggaa      180

ctcaaaccca tcatcgaccg catctacaag acctacgccg atcagtgcct ccagctcgtg      240

cagttggact gggagaacct cagcgcggcc attgactcct accggaagga gaaaacggag      300

gagacgcgca acgcgctcat cgaggaacag gcaacctatc gcaacgccat ccacgactac      360

ttcatcggga ggactgacaa cctcactgac gcgattaaca agcgccacgc ggagatatac      420

aagggactct tcaaagcgga gctgtttaac ggcaaggttc tcaagcaact cggcactgtg      480

accacgaccg agcatgagaa cgccctgctc cgctccttcg acaagttcac cacctacttc      540

tccgggttct accgcaaccg caagaatgtc ttcagcgcgg aggacatcag cacggccatt      600

ccacatcgaa tcgtccaaga taacttcccg aagttcaagg agaactgcca catcttcacc      660

cgactcatta ctgctgtacc gtcgttacgc gaacacttcg agaacgtcaa gaaggcaatt      720

ggaatcttcg tctctacgtc aatagaggag gtgttcagct tccctttcta caaccagctc      780

cttacgcaga cccagataga cctgtacaat cagctcctcg gtgggatcag ccgggaggcg      840

gggactgaga agattaaagg gctcaacgag gtcttgaacc tggccatcca aaaaaacgat      900

gagacggcgc acatcatcgc ctcgctgccc caccggttca tcccgctgtt caagcagatc      960

ctcagtgaca ggaacacctt gagctttatc ctagaggagt tcaagagcga cgaggaggtg     1020

atccagagct tctgcaagta caaaaccctg ctgaggaacg agaacgtcct ggagacggcg     1080

gaggcgctgt tcaacgagct gaactctatc gacttaactc acatattcat ctcgcacaag     1140

aagctggaga ctattagctc tgcactctgc gaccactggg acaccctccg caacgcgctc     1200

tacgagcgcc gcatctcgga gctgaccggg aagatcacca aatccgcgaa ggaaaaggtc     1260

cagcgttccc tcaaacacga ggatattaac ttacaggaga ttatctcagc ggctgggaag     1320

gagttgtcag aggcgttcaa gcagaaaact tccgagatcc tgagccacgc gcacgcagcg     1380

ctcgaccagc ctctgcccac caccctcaaa aagcaggaag aaaaagagat cctcaagagc     1440

cagttggact ccctgctggg gctctatcac cttctcgact ggttcgccgt cgatgagtcg     1500

aacgaggtgg accccgagtt ctccgcccgg ctgaccggca tcaagctaga gatggagccg     1560

tccctcagct tctacaataa ggcccgcaac tacgcgacca aaaaacccta cagcgtggag     1620

aagttcaagc tgaacttcca gatgccgacc ttagcacgcg gttgggacgt aaacagggag     1680

aagaacaatg gagccatcct gttcgtcaag aacgggcttt actacctcgg gataatgccc     1740

aagcagaagg gccgctacaa ggccctttcc ttcgagccga cggagaaaac ctccgagggg     1800

ttcgacaaga tgtactacga ctacttcccc gacgccgcca agatgatccc gaagtgctca     1860

acgcagctaa aagccgtgac cgcccacttc cagacccaca cgacgccgat cctgctgagc     1920

aacaacttca tcgagcccct tgagatcact aaggagatat acgacctgaa caaccccgag     1980

aaggagccca agaagtttca aaccgcctac gccaaaaaaa ctggcgacca aaagggctac     2040

agggaggcgc tgtgtaagtg gatcgacttc acacgcgact tcctttcgaa gtatacgaag     2100

acaacctcta ttgacctgag cagcctgcgt cctagctccc agtacaaaga tttgggcgag     2160

tactacgcgg agcttaatcc actactctac cacatctcat tccagcgcat cgctgagaag     2220

gaaatcatgg acgcggtgga gacaggcaaa ctgtacctct tccagatata caacaaagac     2280

ttcgctaagg ggcaccacgg gaagcccaac cttcatacgc tctactggac gggcctattc     2340

agccccgaaa atctggccaa gacctccatc aagctgaacg gccaagcgga gctgttctac     2400

agacccaaga gccggatgaa gcggatggcc cacaggctcg gcgagaaaat gcttaacaaa     2460

aagttgaagg accagaaaac ccctatcccc gacaccctct accaggaact gtacgactac     2520

gtgaaccaca ggctctcgca cgacctttcc gacgaggccc gtgccctact cccgaacgtc     2580

attaccaaag aggtttcgca cgagatcatc aaggaccggc ggttcacgag cgacaagttt     2640

ttctttcacg tccccatcac ccttaactac caggcggcca actccccatc caagttcaac     2700

cagcgtgtga atgcctacct caaggagcac ccagagaccc cgatcattgg gatcgaccgg     2760

ggcgagcgga acctgatcta catcaccgtc atcgactcga cgggcaagat tcttgagcag     2820

agatcgttga ataccataca gcagttcgac taccagaaga aactcgacaa ccgcgagaag     2880

gagcgcgtgg cggcccgcca ggcgtggtcc gtcgttggga cgattaagga cttgaaacaa     2940

ggttatctgt cccaagtcat ccacgagatc gttgatctga tgatccacta tcaggcagtg     3000

gtggtgctgg agaatctcaa cttcggcttc aagagtaagc ggacgggaat cgccgagaag     3060

gccgtgtacc agcagttcga gaagatgctg atcgacaagc tcaactgcct tgtgctgaaa     3120

gactacccgg ccgagaaggt cggcggcgtc ctcaacccgt accaacttac cgaccagttc     3180

acctccttcg ccaagatggg cactcagtcc gggttcttgt tctacgtccc cgcaccttac     3240

acctctaaga tcgaccctct gactggcttc gtagatccat tcgtgtggaa gaccattaag     3300

aaccacgaga gccgcaagca cttcctggag ggcttcgact tcctgcacta cgacgtgaag     3360

accggggact tcatccttca cttcaagatg aaccggaacc tcagcttcca gcggggcctg     3420

ccggggttca tgcccgcctg ggacatcgtg ttcgagaaga acgagaccca gttcgacgcg     3480

aagggcacgc ccttcatcgc cgggaagcgt atcgtgccgg tgatcgagaa ccatcgtttc     3540

acgggtcgct accgtgacct ctacccggcg aacgagctta tcgcactcct ggaggagaag     3600

ggcatcgtct tccgggacgg ctccaacatc ctcccgaaac tgctggaaaa cgacgactct     3660

cacgccatcg acacgatggt ggccctcatc cggtccgtgc tccaaatgcg gaacagcaac     3720

gccgccaccg gtgaggacta catcaacagc ccggtccggg atctgaacgg ggtgtgcttc     3780

gattcgcggt tccagaatcc tgagtggccg atggacgcgg atgcaaacgg ggcgtaccac     3840

atcgcgctca agggccagtt acttctgaac caccttaagg agtctaaaga tttgaaactc     3900

cagaacggga tctcgaacca ggactggctg gcctacatcc aagagttgcg gaacggcagc     3960

aagaagcggc ggattaagca agattag                                         3987


<210>  21
<211>  1592
<212>  DNA
<213>  Medicago truncatula

<400>  21
actgttaata atttttaaac gtcagcgcac taaaaaaacg aaaagacgga cacgtgaaaa       60

taaaaaacac acactagttt atgacgcaat actattttac ttatgatttg ggtacattag      120

acaaaaccgt gaaagagatg tatcagctat gaaacctgta tacttcaata cagagactta      180

ctcatatcgg atacgtacgc acgaagtatc atattaatta ttttaatttt taataaatat      240

tttatcggat acttatgtga tactctacat atacacaagg atatttctaa gatactttat      300

agatacgtat cctagaaaaa catgaagagt aaaaaagtga gacaatgttg taaaaattca      360

ttataaatgt atatgattca attttagata tgcatcagta taattgattc tcgatgaaac      420

acttaaaatt atatttcttg tggaagaacg tagcgagaga ggtgattcag ttagacaaca      480

ttaaataaaa ttaatgttaa gttcttttaa tgatgtttct ctcaatatca catcatatga      540

aaatgtaata tgatttataa gaaaattttt aaaaaattta ttttaataat cacatgtact      600

attttttaaa aattgtatct tttataataa tacaataata aagagtaatc agtgttaatt      660

tttcttcaaa tataagtttt attataaatc attgttaacg tatcataagt cattaccgta      720

tcgtatctta attttttttt aaaaaccgct aattcacgta cccgtattgt attgtacccg      780

cacctgtatc acaatcgatc ttagttagaa gaattgtctc gaggcggtgc aagacagcat      840

ataatagacg tggactctct tataccaaac gttgtcgtat cacaaagggt taggtaacaa      900

gtcacagttt gtccacgtgt cacgttttaa ttggaagagg tgccgttggc gtaatataac      960

agccaatcga tttttgctat aaaagcaaat caggtaaact aaacttcttc attcttttct     1020

tccccatcgc tacaaaaccg gttcctttgg aaaagagatt cattcaaacc tagcacccaa     1080

ttccgtttca aggtataatc tactttctat tcttcgatta ttttattatt attagctact     1140

atcgtttaat cgatcttttc ttttgatccg tcaaatttaa attcaattag ggttttgttc     1200

ttttctttca tctgattgaa atccttctga attgaaccgt ttacttgatt ttactgttta     1260

ttgtatgatt taatcctttg tttttcaaag acagtcttta gattgtgatt aggggttcat     1320

ataaattttt agatttggat ttttgtattg tatgattcaa aaaatacgtc ctttaattag     1380

attagtacat ggatattttt tacccgattt attgattgtc agggagaatt tgatgagcaa     1440

gtttttttga tgtctgttgt aaattgaatt gattataatt gctgatctgc tgcttccagt     1500

tttcataacc catattcttt taaccttgtt gtacacacaa tgaaaaattg gtgattgatt     1560

catttgtttt tctttgtttt ggattataca gg                                   1592


<210>  22
<211>  2000
<212>  DNA
<213>  Zea mays

<400>  22
gtcgtgcccc tctctagaga taaagagcat tgcatgtcta aagtataaaa aattaccaca       60

tatttttttg tcacacttat ttgaagtgta gtttatctat ctctatacat atatttaaac      120

ttcactctac aaataatata gtctataata ctaaaataat attagtgttt tagaggatca      180

tataaataaa ctgctagaca tggtctaaag gataattgaa tattttgaca atctacagtt      240

ttatcttttt agtgtgcatg tgatctctct gttttttttg caaatagctt gacctatata      300

atacttcatc cattttatta gtacatccat ttaggattta gggttgatgg tttctataga      360

ctaattttta gtacatccat tttattcttt ttagtctcta aattttttaa aactaaaact      420

ctattttagt tttttattta ataatttaga tataaaatga aataaaataa attgactaca      480

aataaaacaa atacccttta agaaataaaa aaactaagca aacatttttc ttgtttcgag      540

tagataatga caggctgttc aacgccgtcg acgagtctaa cggacaccaa ccagcgaacc      600

agcagcgtcg cgtcgggcca agcgaagcag acggcacggc atctctgtag ctgcctctgg      660

acccctctcg agagttccgc tccaccgttg gacttgctcc gctgtcggca tccagaaatt      720

gcgtggcgga gcggcagacg tgaggcggca cggcaggcgg cctcttcctc ctctcacggc      780

accggcagct acgggggatt cctttcccac cgctccttcg ctttcccttc ctcgcccgcc      840

gtaataaata gacaccccct ccacaccctc tttccccaac ctcgtgttcg ttcggagcgc      900

acacacacgc aaccagatct cccccaaatc cagccgtcgg cacctccgct tcaaggtacg      960

ccgctcatcc tccccccccc cctctctcta ccttctctag atcggcgatc cggtccatgg     1020

ttagggcccg gtagttctac ttctgttcat gtttgtgtta gagcaaacat gttcatgttc     1080

atgtttgtga tgatgtggtc tggttgggcg gtcgttctag atcggagtag gatactgttt     1140

caagctacct ggtggattta ttaattttgt atctgtatgt gtgtgccata catcttcata     1200

gttacgagtt taagatgatg gatggaaata tcgatctagg ataggtatac atgttgatgc     1260

gggttttact gatgcatata cagagatgct ttttttctcg cttggttgtg atgatatggt     1320

ctggttgggc ggtcgttcta gatcggagta gaatactgtt tcaaactacc tggtggattt     1380

attaaaggat aaagggtcgt tctagatcgg agtagaatac tgtttcaaac tacctggtgg     1440

atttattaaa ggatctgtat gtatgtgcct acatcttcat agttacgagt ttaagatgat     1500

ggatggaaat atcgatctag gataggtata catgttgatg cgggttttac tgatgcatat     1560

acagagatgc tttttttcgc ttggttgtga tgatgtggtc tggttgggcg gtcgttctag     1620

atcggagtag aatactgttt caaactacct ggtggattta ttaattttgt atctttatgt     1680

gtgtgccata catcttcata gttacgagtt taagatgatg gatggaaata ttgatctagg     1740

ataggtatac atgttgatgt gggttttact gatgcatata catgatggca tatgcggcat     1800

ctattcatat gctctaacct tgagtaccta tctattataa taaacaagta tgttttataa     1860

ttattttgat cttgatatac ttggatgatg gcatatgcag cagctatatg tggatttttt     1920

agccctgcct tcatacgcta tttatttgct tggtactgtt tcttttgtcc gatgctcacc     1980

ctgttgtttg gtgatacttc                                                 2000


<210>  23
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  GCN4 sequence

<400>  23

Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys Gly Ser Gly Ser Gly 
            20                  


<210>  24
<211>  241
<212>  PRT
<213>  Artificial

<220>
<223>  10-mer GCN4 sequence

<400>  24

Glu Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
1               5                   10                  15      


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
            20                  25                  30          


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
        35                  40                  45              


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
    50                  55                  60                  


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
65                  70                  75                  80  


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
                85                  90                  95      


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
            100                 105                 110         


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
        115                 120                 125             


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
    130                 135                 140                 


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
145                 150                 155                 160 


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
                165                 170                 175     


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
            180                 185                 190         


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
        195                 200                 205             


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
    210                 215                 220                 


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
225                 230                 235                 240 


Gly 
    


<210>  25
<211>  277
<212>  PRT
<213>  Artificial

<220>
<223>  ScFv antibody

<400>  25

Met Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala 
            20                  25                  30          


Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys 
        35                  40                  45              


Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu 
                85                  90                  95      


Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly 
145                 150                 155                 160 


Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp 
            180                 185                 190         


Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr 
    210                 215                 220                 


Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser 
        275         


<210>  26
<211>  66
<212>  DNA
<213>  Saccharomyces bayanus

<400>  26
ttcttgtcgt acttatagat cgctacgtta tttcaatttt gaaaatctga gtcctgggag       60

tgcgga                                                                  66


<210>  27
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Trp Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser Val 
                85                  90                  95      


Asn Phe Lys Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly Ala Lys 
            100                 105                 110         


Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln Lys Arg 
        115                 120                 125             


Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser Glu Val 
    130                 135                 140                 


Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys Met Ser 
145                 150                 155                 160 


His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His Gly Asn 
                165                 170                 175     


Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp Leu Arg 
            180                 185                 190         


Asp Thr Gly Ile Phe Leu Asp Leu His Leu Lys Lys Pro Gly Gly Phe 
        195                 200                 205             


Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala Glu Asp Glu 
    210                 215                 220                 


Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu Asp Leu Leu 
225                 230                 235                 240 


Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu Ser Arg Leu 
                245                 250                 255     


Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly Ile Tyr Asn 
            260                 265                 270         


Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu Tyr Arg Glu 
        275                 280                 285             


Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn Thr Ser Thr 
    290                 295                 300                 


Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln Ile Tyr Gly 
305                 310                 315                 320 


Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu Leu Lys Arg 
                325                 330                 335     


Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro Leu Val Leu 
            340                 345                 350         


Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val Tyr Pro Glu 
        355                 360                 365             


Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala Leu Leu Ile 
    370                 375                 380                 


Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr Thr Pro Arg 
385                 390                 395                 400 


Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln Glu Glu Glu 
                405                 410                 415     


Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe Gln Leu Val 
            420                 425                 430         


Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe Thr Glu Lys 
        435                 440                 445             


Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala Ile Val Glu 
    450                 455                 460                 


Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn Pro Val Leu 
465                 470                 475                 480 


Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp Leu Met Glu 
                485                 490                 495     


Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu Ala Met Asn 
            500                 505                 510         


Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu Val Tyr Pro 
        515                 520                 525             


Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys His Asp Asn 
    530                 535                 540                 


Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser Glu Glu Glu 
545                 550                 555                 560 


Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe Thr Val Pro 
                565                 570                 575     


Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser Gly Leu Lys Lys 
            580                 585                 590         


Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln Asp 
        595                 600                 605 


<210>  28
<211>  482
<212>  PRT
<213>  Artificial

<220>
<223>  polypeptide

<400>  28

Met Val Arg Ser Gly Asn Lys Ala Ala Trp Leu Cys Met Asp Val Gly 
1               5                   10                  15      


Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu Gln 
            20                  25                  30          


Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala Glu 
        35                  40                  45              


Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr Asp 
    50                  55                  60                  


Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His Arg 
65                  70                  75                  80  


His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser Lys 
                85                  90                  95      


Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile Val 
            100                 105                 110         


Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu Lys 
        115                 120                 125             


Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys Ser 
    130                 135                 140                 


Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser Glu 
145                 150                 155                 160 


Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn Leu 
                165                 170                 175     


Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val Lys 
            180                 185                 190         


Lys Thr Thr Trp Asp Ala Lys Thr Leu Lys Lys Glu Asp Ile Gln Lys 
        195                 200                 205             


Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu Val Leu Lys 
    210                 215                 220                 


Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile Val Pro Phe 
225                 230                 235                 240 


Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu Gly Lys Cys 
                245                 250                 255     


Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln Arg Arg Phe 
            260                 265                 270         


Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg Asp Asp Glu 
        275                 280                 285             


Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu Asp Asp Leu 
    290                 295                 300                 


Asp Ile Trp Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg Ala Asn Pro 
305                 310                 315                 320 


Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr Glu Cys Leu 
                325                 330                 335     


Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln Tyr Met Phe 
            340                 345                 350         


Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu Ala Gln Leu 
        355                 360                 365             


Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala Lys Lys Asp 
    370                 375                 380                 


Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr Lys Ile Pro 
385                 390                 395                 400 


Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His Arg Ala Leu 
                405                 410                 415     


His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile Trp Asn Met 
            420                 425                 430         


Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile Pro Leu Ser 
        435                 440                 445             


Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys Lys Asp Gln 
    450                 455                 460                 


Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp Gly Pro Thr 
465                 470                 475                 480 


Ala Lys 
        


<210>  29
<211>  10
<212>  DNA
<213>  Methanobacterium thermoautotrophicum

<400>  29
aatttttgga                                                              10


<210>  30
<211>  83
<212>  PRT
<213>  Methanobacterium thermoautotrophicum

<400>  30

Gly Ser Val Ile Asp Val Ser Ser Gln Arg Val Asn Val Gln Arg Pro 
1               5                   10                  15      


Leu Asp Ala Leu Gly Asn Ser Leu Asn Ser Pro Val Ile Ile Lys Leu 
            20                  25                  30          


Lys Gly Asp Arg Glu Phe Arg Gly Val Leu Lys Ser Phe Asp Leu His 
        35                  40                  45              


Met Asn Leu Val Leu Asn Asp Ala Glu Glu Leu Glu Asp Gly Glu Val 
    50                  55                  60                  


Thr Arg Arg Leu Gly Thr Val Leu Ile Arg Gly Asp Asn Ile Val Tyr 
65                  70                  75                  80  


Ile Ser Pro 
            


<210>  31
<211>  25
<212>  DNA
<213>  Bacteriophage MS2

<400>  31
gcgcacatga ggatcaccca tgtgc                                             25


<210>  32
<211>  116
<212>  PRT
<213>  Bacteriophage MS2

<400>  32

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
65                  70                  75                  80  


Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
                85                  90                  95      


Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
            100                 105                 110         


Ser Gly Ile Tyr 
        115     


<210>  33
<211>  26
<212>  DNA
<213>  Bacteriophage PP7

<400>  33
ataaggagtt tatatggaaa ccctta                                            26


<210>  34
<211>  127
<212>  PRT
<213>  Bacteriophage PP7

<400>  34

Met Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu 
1               5                   10                  15      


Thr Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val 
            20                  25                  30          


Gly Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn 
        35                  40                  45              


Gly Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp 
    50                  55                  60                  


Trp Asp Cys Ser Thr Ser Val Cys Gly Glu Leu Pro Lys Val Arg Tyr 
65                  70                  75                  80  


Thr Gln Val Trp Ser His Asp Val Thr Ile Val Ala Asn Ser Thr Glu 
                85                  90                  95      


Ala Ser Arg Lys Ser Leu Tyr Asp Leu Thr Lys Ser Leu Val Ala Thr 
            100                 105                 110         


Ser Gln Val Glu Asp Leu Val Val Asn Leu Val Pro Leu Gly Arg 
        115                 120                 125         


<210>  35
<211>  19
<212>  DNA
<213>  Shigella phage

<400>  35
ctgaatgcct gcgagcatc                                                    19


<210>  36
<211>  62
<212>  PRT
<213>  Shigella phage

<400>  36

Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr 
    50                  55                  60          


<210>  37
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Spacer


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  wherein n is A, C, T or G

<400>  37
nnnnnnnnnn nnnnnnnnn                                                    19


<210>  38
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Target strand


<220>
<221>  misc_feature
<222>  (4)..(22)
<223>  wherein n is A, C, T or G

<400>  38
aaannnnnnn nnnnnnnnnn nn                                                22


<210>  39
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Non-target strand


<220>
<221>  misc_feature
<222>  (4)..(22)
<223>  wherein n is A, C, T or G

<400>  39
tttnnnnnnn nnnnnnnnnn nn                                                22


<210>  40
<211>  15
<212>  DNA
<213>  Unknown

<220>
<223>  Porcine circovirus

<400>  40
aagtattacc agaaa                                                        15


<210>  41
<211>  15
<212>  DNA
<213>  Unknown

<220>
<223>  Duck circovirus

<400>  41
aagtattacc agaaa                                                        15


<210>  42
<211>  15
<212>  DNA
<213>  Fava bean necrosis yellows virus

<400>  42
aagtattacc agaaa                                                        15


<210>  43
<211>  23
<212>  DNA
<213>  Streptococcus agalactiae

<400>  43
tgcttccgta ctacgacccc cca                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Fructobacillus tropaeoli

<400>  44
tgcttccgta ctacgacccc cca                                               23


<210>  45
<211>  22
<212>  DNA
<213>  Escherichia coli

<400>  45
tttgcgtggg gtgtggtgct tt                                                22


<210>  46
<211>  38
<212>  DNA
<213>  Escherichia coli

<400>  46
ccagtttctc gaagagaaac cggtaagtgc accctccc                               38


<210>  47
<211>  45
<212>  DNA
<213>  Staphylococcus aureus

<400>  47
acgcgaacgg aacgttcgca taagtgcgcc cttacgggat ttaac                       45


<210>  48
<211>  2286
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Leu Arg Ser Gly Gly Arg Arg Arg Ala Asp Pro Gly Ala Asp 
1               5                   10                  15      


Gly Glu Ala Ser Arg Asp Asp Gly Ala Thr Ser Ser Val Ser Ala Leu 
            20                  25                  30          


Lys Arg Leu Glu Arg Ser Gln Trp Thr Asp Lys Met Asp Leu Arg Phe 
        35                  40                  45              


Gly Phe Glu Arg Leu Lys Glu Pro Gly Glu Lys Thr Gly Trp Leu Ile 
    50                  55                  60                  


Asn Met His Pro Thr Glu Ile Leu Asp Glu Asp Lys Arg Leu Gly Ser 
65                  70                  75                  80  


Ala Val Asp Tyr Tyr Phe Ile Gln Asp Asp Gly Ser Arg Phe Lys Val 
                85                  90                  95      


Ala Leu Pro Tyr Lys Pro Tyr Phe Tyr Ile Ala Thr Arg Lys Gly Cys 
            100                 105                 110         


Glu Arg Glu Val Ser Ser Phe Leu Ser Lys Lys Phe Gln Gly Lys Ile 
        115                 120                 125             


Ala Lys Val Glu Thr Val Pro Lys Glu Asp Leu Asp Leu Pro Asn His 
    130                 135                 140                 


Leu Val Gly Leu Lys Arg Asn Tyr Ile Arg Leu Ser Phe His Thr Val 
145                 150                 155                 160 


Glu Asp Leu Val Lys Val Arg Lys Glu Ile Ser Pro Ala Val Lys Lys 
                165                 170                 175     


Asn Arg Glu Gln Asp His Ala Ser Asp Ala Tyr Thr Ala Leu Leu Ser 
            180                 185                 190         


Ser Val Leu Gln Arg Gly Gly Val Ile Thr Asp Glu Glu Glu Thr Ser 
        195                 200                 205             


Lys Lys Ile Ala Asp Gln Leu Asp Asn Ile Val Asp Met Arg Glu Tyr 
    210                 215                 220                 


Asp Val Pro Tyr His Ile Arg Leu Ser Ile Asp Leu Lys Ile His Val 
225                 230                 235                 240 


Ala His Trp Tyr Asn Val Arg Tyr Arg Gly Asn Ala Phe Pro Val Glu 
                245                 250                 255     


Ile Thr Arg Arg Asp Asp Leu Val Glu Arg Pro Asp Pro Val Val Leu 
            260                 265                 270         


Ala Phe Asp Ile Glu Thr Thr Lys Leu Pro Leu Lys Phe Pro Asp Ala 
        275                 280                 285             


Glu Thr Asp Gln Ile Met Met Ile Ser Tyr Met Ile Asp Gly Gln Gly 
    290                 295                 300                 


Tyr Leu Ile Thr Asn Arg Glu Ile Val Ser Glu Asp Ile Glu Asp Phe 
305                 310                 315                 320 


Glu Phe Thr Pro Lys Pro Glu Tyr Glu Gly Pro Phe Cys Val Phe Asn 
                325                 330                 335     


Glu Pro Asp Glu Ala His Leu Ile Gln Arg Trp Phe Glu His Val Gln 
            340                 345                 350         


Glu Thr Lys Pro Thr Ile Met Val Thr Tyr Asn Gly Asp Phe Phe Asp 
        355                 360                 365             


Trp Pro Phe Val Glu Ala Arg Ala Ala Val His Gly Leu Ser Met Gln 
    370                 375                 380                 


Gln Glu Ile Gly Phe Gln Lys Asp Ser Gln Gly Glu Tyr Lys Ala Pro 
385                 390                 395                 400 


Gln Cys Ile His Met Asp Cys Leu Arg Trp Val Lys Arg Asp Ser Tyr 
                405                 410                 415     


Leu Pro Val Gly Ser His Asn Leu Lys Ala Ala Ala Lys Ala Lys Leu 
            420                 425                 430         


Gly Tyr Asp Pro Val Glu Leu Asp Pro Glu Asp Met Cys Arg Met Ala 
        435                 440                 445             


Thr Glu Gln Pro Gln Thr Leu Ala Thr Tyr Ser Val Ser Asp Ala Val 
    450                 455                 460                 


Ala Thr Tyr Tyr Leu Tyr Met Lys Tyr Val His Pro Phe Ile Phe Ala 
465                 470                 475                 480 


Leu Cys Thr Ile Ile Pro Met Glu Pro Asp Glu Val Leu Arg Lys Gly 
                485                 490                 495     


Ser Gly Thr Leu Cys Glu Ala Leu Leu Met Val Gln Ala Phe His Ala 
            500                 505                 510         


Asn Ile Ile Phe Pro Asn Lys Gln Glu Gln Glu Phe Asn Lys Leu Thr 
        515                 520                 525             


Asp Asp Gly His Val Leu Asp Ser Glu Thr Tyr Val Gly Gly His Val 
    530                 535                 540                 


Glu Ala Leu Glu Ser Gly Val Phe Arg Ser Asp Ile Pro Cys Arg Phe 
545                 550                 555                 560 


Arg Met Asn Pro Ala Ala Phe Asp Phe Leu Leu Gln Arg Val Glu Lys 
                565                 570                 575     


Thr Leu Arg His Ala Leu Glu Glu Glu Glu Lys Val Pro Val Glu Gln 
            580                 585                 590         


Val Thr Asn Phe Glu Glu Val Cys Asp Glu Ile Lys Ser Lys Leu Ala 
        595                 600                 605             


Ser Leu Lys Asp Val Pro Ser Arg Ile Glu Cys Pro Leu Ile Tyr His 
    610                 615                 620                 


Leu Asp Val Gly Ala Met Tyr Pro Asn Ile Ile Leu Thr Asn Arg Leu 
625                 630                 635                 640 


Gln Pro Ser Ala Met Val Asp Glu Ala Thr Cys Ala Ala Cys Asp Phe 
                645                 650                 655     


Asn Lys Pro Gly Ala Asn Cys Gln Arg Lys Met Ala Trp Gln Trp Arg 
            660                 665                 670         


Gly Glu Phe Met Pro Ala Ser Arg Ser Glu Tyr His Arg Ile Gln His 
        675                 680                 685             


Gln Leu Glu Ser Glu Lys Phe Pro Pro Leu Phe Pro Glu Gly Pro Ala 
    690                 695                 700                 


Arg Ala Phe His Glu Leu Ser Arg Glu Glu Gln Ala Lys Tyr Glu Lys 
705                 710                 715                 720 


Arg Arg Leu Ala Asp Tyr Cys Arg Lys Ala Tyr Lys Lys Ile His Ile 
                725                 730                 735     


Thr Lys Val Glu Glu Arg Leu Thr Thr Ile Cys Gln Arg Glu Asn Ser 
            740                 745                 750         


Phe Tyr Val Asp Thr Val Arg Ala Phe Arg Asp Arg Arg Tyr Glu Phe 
        755                 760                 765             


Lys Gly Leu His Lys Val Trp Lys Lys Lys Leu Ser Ala Ala Val Glu 
    770                 775                 780                 


Val Gly Asp Ala Ala Glu Val Lys Arg Cys Lys Asn Met Glu Val Leu 
785                 790                 795                 800 


Tyr Asp Ser Leu Gln Leu Ala His Lys Cys Ile Leu Asn Ser Phe Tyr 
                805                 810                 815     


Gly Tyr Val Met Arg Lys Gly Ala Arg Trp Tyr Ser Met Glu Met Ala 
            820                 825                 830         


Gly Ile Val Cys Phe Thr Gly Ala Asn Ile Ile Thr Gln Ala Arg Glu 
        835                 840                 845             


Leu Ile Glu Gln Ile Gly Arg Pro Leu Glu Leu Asp Thr Asp Gly Ile 
    850                 855                 860                 


Trp Cys Val Leu Pro Asn Ser Phe Pro Glu Asn Phe Val Phe Lys Thr 
865                 870                 875                 880 


Thr Asn Val Lys Lys Pro Lys Val Thr Ile Ser Tyr Pro Gly Ala Met 
                885                 890                 895     


Leu Asn Ile Met Val Lys Glu Gly Phe Thr Asn Asp Gln Tyr Gln Glu 
            900                 905                 910         


Leu Ala Glu Pro Ser Ser Leu Thr Tyr Val Thr Arg Ser Glu Asn Ser 
        915                 920                 925             


Ile Phe Phe Glu Val Asp Gly Pro Tyr Leu Ala Met Ile Leu Pro Ala 
    930                 935                 940                 


Ser Lys Glu Glu Gly Lys Lys Leu Lys Lys Arg Tyr Ala Val Phe Asn 
945                 950                 955                 960 


Glu Asp Gly Ser Leu Ala Glu Leu Lys Gly Phe Glu Val Lys Arg Arg 
                965                 970                 975     


Gly Glu Leu Gln Leu Ile Lys Ile Phe Gln Ser Ser Val Phe Glu Ala 
            980                 985                 990         


Phe Leu Lys Gly Ser Thr Leu Glu  Glu Val Tyr Gly Ser  Val Ala Lys 
        995                 1000                 1005             


Val Ala  Asp Tyr Trp Leu Asp  Val Leu Tyr Ser Lys  Ala Ala Asn 
    1010                 1015                 1020             


Met Pro  Asp Ser Glu Leu Phe  Glu Leu Ile Ser Glu  Asn Arg Ser 
    1025                 1030                 1035             


Met Ser  Arg Lys Leu Glu Asp  Tyr Gly Glu Gln Lys  Ser Thr Ser 
    1040                 1045                 1050             


Ile Ser  Thr Ala Lys Arg Leu  Ala Glu Phe Leu Gly  Asp Gln Met 
    1055                 1060                 1065             


Val Lys  Asp Ala Gly Leu Ser  Cys Arg Tyr Ile Ile  Ser Arg Lys 
    1070                 1075                 1080             


Pro Glu  Gly Ser Pro Val Thr  Glu Arg Ala Ile Pro  Leu Ala Ile 
    1085                 1090                 1095             


Phe Gln  Ala Glu Pro Thr Val  Arg Lys His Phe Leu  Arg Lys Trp 
    1100                 1105                 1110             


Leu Lys  Ser Ser Ser Leu Gln  Asp Phe Asp Ile Arg  Ala Ile Leu 
    1115                 1120                 1125             


Asp Trp  Asp Tyr Tyr Ile Glu  Arg Leu Gly Ser Ala  Ile Gln Lys 
    1130                 1135                 1140             


Ile Ile  Thr Ile Pro Ala Ala  Leu Gln Gln Val Lys  Asn Pro Val 
    1145                 1150                 1155             


Pro Arg  Val Lys His Pro Asp  Trp Leu His Lys Lys  Leu Leu Glu 
    1160                 1165                 1170             


Lys Asn  Asp Val Tyr Lys Gln  Lys Lys Ile Ser Glu  Leu Phe Thr 
    1175                 1180                 1185             


Leu Glu  Gly Arg Arg Gln Val  Thr Met Ala Glu Ala  Ser Glu Asp 
    1190                 1195                 1200             


Ser Pro  Arg Pro Ser Ala Pro  Asp Met Glu Asp Phe  Gly Leu Val 
    1205                 1210                 1215             


Lys Leu  Pro His Pro Ala Ala  Pro Val Thr Val Lys  Arg Lys Arg 
    1220                 1225                 1230             


Val Leu  Trp Glu Ser Gln Glu  Glu Ser Gln Asp Leu  Thr Pro Thr 
    1235                 1240                 1245             


Val Pro  Trp Gln Glu Ile Leu  Gly Gln Pro Pro Ala  Leu Gly Thr 
    1250                 1255                 1260             


Ser Gln  Glu Glu Trp Leu Val  Trp Leu Arg Phe His  Lys Lys Lys 
    1265                 1270                 1275             


Trp Gln  Leu Gln Ala Arg Gln  Arg Leu Ala Arg Arg  Lys Arg Gln 
    1280                 1285                 1290             


Arg Leu  Glu Ser Ala Glu Gly  Val Leu Arg Pro Gly  Ala Ile Arg 
    1295                 1300                 1305             


Asp Gly  Pro Ala Thr Gly Leu  Gly Ser Phe Leu Arg  Arg Thr Ala 
    1310                 1315                 1320             


Arg Ser  Ile Leu Asp Leu Pro  Trp Gln Ile Val Gln  Ile Ser Glu 
    1325                 1330                 1335             


Thr Ser  Gln Ala Gly Leu Phe  Arg Leu Trp Ala Leu  Val Gly Ser 
    1340                 1345                 1350             


Asp Leu  His Cys Ile Arg Leu  Ser Ile Pro Arg Val  Phe Tyr Val 
    1355                 1360                 1365             


Asn Gln  Arg Val Ala Lys Ala  Glu Glu Gly Ala Ser  Tyr Arg Lys 
    1370                 1375                 1380             


Val Asn  Arg Val Leu Pro Arg  Ser Asn Met Val Tyr  Asn Leu Tyr 
    1385                 1390                 1395             


Glu Tyr  Ser Val Pro Glu Asp  Met Tyr Gln Glu His  Ile Asn Glu 
    1400                 1405                 1410             


Ile Asn  Ala Glu Leu Ser Ala  Pro Asp Ile Glu Gly  Val Tyr Glu 
    1415                 1420                 1425             


Thr Gln  Val Pro Leu Leu Phe  Arg Ala Leu Val His  Leu Gly Cys 
    1430                 1435                 1440             


Val Cys  Val Val Asn Lys Gln  Leu Val Arg His Leu  Ser Gly Trp 
    1445                 1450                 1455             


Glu Ala  Glu Thr Phe Ala Leu  Glu His Leu Glu Met  Arg Ser Leu 
    1460                 1465                 1470             


Ala Gln  Phe Ser Tyr Leu Glu  Pro Gly Ser Ile Arg  His Ile Tyr 
    1475                 1480                 1485             


Leu Tyr  His His Ala Gln Ala  His Lys Ala Leu Phe  Gly Ile Phe 
    1490                 1495                 1500             


Ile Pro  Ser Gln Arg Arg Ala  Ser Val Phe Val Leu  Asp Thr Val 
    1505                 1510                 1515             


Arg Ser  Asn Gln Met Pro Ser  Leu Gly Ala Leu Tyr  Ser Ala Glu 
    1520                 1525                 1530             


His Gly  Leu Leu Leu Glu Lys  Val Gly Pro Glu Leu  Leu Pro Pro 
    1535                 1540                 1545             


Pro Lys  His Thr Phe Glu Val  Arg Ala Glu Thr Asp  Leu Lys Thr 
    1550                 1555                 1560             


Ile Cys  Arg Ala Ile Gln Arg  Phe Leu Leu Ala Tyr  Lys Glu Glu 
    1565                 1570                 1575             


Arg Arg  Gly Pro Thr Leu Ile  Ala Val Gln Ser Ser  Trp Glu Leu 
    1580                 1585                 1590             


Lys Arg  Leu Ala Ser Glu Ile  Pro Val Leu Glu Glu  Phe Pro Leu 
    1595                 1600                 1605             


Val Pro  Ile Cys Val Ala Asp  Lys Ile Asn Tyr Gly  Val Leu Asp 
    1610                 1615                 1620             


Trp Gln  Arg His Gly Ala Arg  Arg Met Ile Arg His  Tyr Leu Asn 
    1625                 1630                 1635             


Leu Asp  Thr Cys Leu Ser Gln  Ala Phe Glu Met Ser  Arg Tyr Phe 
    1640                 1645                 1650             


His Ile  Pro Ile Gly Asn Leu  Pro Glu Asp Ile Ser  Thr Phe Gly 
    1655                 1660                 1665             


Ser Asp  Leu Phe Phe Ala Arg  His Leu Gln Arg His  Asn His Leu 
    1670                 1675                 1680             


Leu Trp  Leu Ser Pro Thr Ala  Arg Pro Asp Leu Gly  Gly Lys Glu 
    1685                 1690                 1695             


Ala Asp  Asp Asn Cys Leu Val  Met Glu Phe Asp Asp  Gln Ala Thr 
    1700                 1705                 1710             


Val Glu  Ile Asn Ser Ser Gly  Cys Tyr Ser Thr Val  Cys Val Glu 
    1715                 1720                 1725             


Leu Asp  Leu Gln Asn Leu Ala  Val Asn Thr Ile Leu  Gln Ser His 
    1730                 1735                 1740             


His Val  Asn Asp Met Glu Gly  Ala Asp Ser Met Gly  Ile Ser Phe 
    1745                 1750                 1755             


Asp Val  Ile Gln Gln Ala Ser  Leu Glu Asp Met Ile  Thr Gly Gly 
    1760                 1765                 1770             


Gln Ala  Ala Ser Ala Pro Ala  Ser Tyr Asp Glu Thr  Ala Leu Cys 
    1775                 1780                 1785             


Ser Asn  Thr Phe Arg Ile Leu  Lys Ser Met Val Val  Gly Trp Val 
    1790                 1795                 1800             


Lys Glu  Ile Thr Gln Tyr His  Asn Ile Tyr Ala Asp  Asn Gln Val 
    1805                 1810                 1815             


Met His  Phe Tyr Arg Trp Leu  Arg Ser Pro Ser Ser  Leu Leu His 
    1820                 1825                 1830             


Asp Pro  Ala Leu His Arg Thr  Leu His Asn Met Met  Lys Lys Leu 
    1835                 1840                 1845             


Phe Leu  Gln Leu Ile Ala Glu  Phe Lys Arg Leu Gly  Ser Ser Val 
    1850                 1855                 1860             


Ile Tyr  Ala Asn Phe Asn Arg  Ile Ile Leu Cys Thr  Lys Lys Arg 
    1865                 1870                 1875             


Arg Val  Glu Asp Ala Ile Ala  Tyr Val Glu Tyr Ile  Thr Ser Ser 
    1880                 1885                 1890             


Ile His  Ser Lys Glu Thr Phe  His Ser Leu Thr Ile  Ser Phe Ser 
    1895                 1900                 1905             


Arg Cys  Trp Glu Phe Leu Leu  Trp Met Asp Pro Ser  Asn Tyr Gly 
    1910                 1915                 1920             


Gly Ile  Lys Gly Lys Val Ser  Ser Arg Ile His Cys  Gly Leu Gln 
    1925                 1930                 1935             


Asp Ser  Gln Lys Ala Gly Gly  Ala Glu Asp Glu Gln  Glu Asn Glu 
    1940                 1945                 1950             


Asp Asp  Glu Glu Glu Arg Asp  Gly Glu Glu Glu Glu  Glu Ala Glu 
    1955                 1960                 1965             


Glu Ser  Asn Val Glu Asp Leu  Leu Glu Asn Asn Trp  Asn Ile Leu 
    1970                 1975                 1980             


Gln Phe  Leu Pro Gln Ala Ala  Ser Cys Gln Asn Tyr  Phe Leu Met 
    1985                 1990                 1995             


Ile Val  Ser Ala Tyr Ile Val  Ala Val Tyr His Cys  Met Lys Asp 
    2000                 2005                 2010             


Gly Leu  Arg Arg Ser Ala Pro  Gly Ser Thr Pro Val  Arg Arg Arg 
    2015                 2020                 2025             


Gly Ala  Ser Gln Leu Ser Gln  Glu Ala Glu Gly Ala  Val Gly Ala 
    2030                 2035                 2040             


Leu Pro  Gly Met Ile Thr Phe  Ser Gln Asp Tyr Val  Ala Asn Glu 
    2045                 2050                 2055             


Leu Thr  Gln Ser Phe Phe Thr  Ile Thr Gln Lys Ile  Gln Lys Lys 
    2060                 2065                 2070             


Val Thr  Gly Ser Arg Asn Ser  Thr Glu Leu Ser Glu  Met Phe Pro 
    2075                 2080                 2085             


Val Leu  Pro Gly Ser His Leu  Leu Leu Asn Asn Pro  Ala Leu Glu 
    2090                 2095                 2100             


Phe Ile  Lys Tyr Val Cys Lys  Val Leu Ser Leu Asp  Thr Asn Ile 
    2105                 2110                 2115             


Thr Asn  Gln Val Asn Lys Leu  Asn Arg Asp Leu Leu  Arg Leu Val 
    2120                 2125                 2130             


Asp Val  Gly Glu Phe Ser Glu  Glu Ala Gln Phe Arg  Asp Pro Cys 
    2135                 2140                 2145             


Arg Ser  Tyr Val Leu Pro Glu  Val Ile Cys Arg Ser  Cys Asn Phe 
    2150                 2155                 2160             


Cys Arg  Asp Leu Asp Leu Cys  Lys Asp Ser Ser Phe  Ser Glu Asp 
    2165                 2170                 2175             


Gly Ala  Val Leu Pro Gln Trp  Leu Cys Ser Asn Cys  Gln Ala Pro 
    2180                 2185                 2190             


Tyr Asp  Ser Ser Ala Ile Glu  Met Thr Leu Val Glu  Val Leu Gln 
    2195                 2200                 2205             


Lys Lys  Leu Met Ala Phe Thr  Leu Gln Asp Leu Val  Cys Leu Lys 
    2210                 2215                 2220             


Cys Arg  Gly Val Lys Glu Thr  Ser Met Pro Val Tyr  Cys Ser Cys 
    2225                 2230                 2235             


Ala Gly  Asp Phe Ala Leu Thr  Ile His Thr Gln Val  Phe Met Glu 
    2240                 2245                 2250             


Gln Ile  Gly Ile Phe Arg Asn  Ile Ala Gln His Tyr  Gly Met Ser 
    2255                 2260                 2265             


Tyr Leu  Leu Glu Thr Leu Glu  Trp Leu Leu Gln Lys  Asn Pro Gln 
    2270                 2275                 2280             


Leu Gly  His 
    2285     


<210>  49
<211>  1462
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Pro Val His Gly Asp Asp Ser Leu Ser Asp Ser Gly Ser Phe 
1               5                   10                  15      


Val Ser Ser Arg Ala Arg Arg Glu Lys Lys Ser Lys Lys Gly Arg Gln 
            20                  25                  30          


Glu Ala Leu Glu Arg Leu Lys Lys Ala Lys Ala Gly Glu Lys Tyr Lys 
        35                  40                  45              


Tyr Glu Val Glu Asp Phe Thr Gly Val Tyr Glu Glu Val Asp Glu Glu 
    50                  55                  60                  


Gln Tyr Ser Lys Leu Val Gln Ala Arg Gln Asp Asp Asp Trp Ile Val 
65                  70                  75                  80  


Asp Asp Asp Gly Ile Gly Tyr Val Glu Asp Gly Arg Glu Ile Phe Asp 
                85                  90                  95      


Asp Asp Leu Glu Asp Asp Ala Leu Asp Ala Asp Glu Lys Gly Lys Asp 
            100                 105                 110         


Gly Lys Ala Arg Asn Lys Asp Lys Arg Asn Val Lys Lys Leu Ala Val 
        115                 120                 125             


Thr Lys Pro Asn Asn Ile Lys Ser Met Phe Ile Ala Cys Ala Gly Lys 
    130                 135                 140                 


Lys Thr Ala Asp Lys Ala Val Asp Leu Ser Lys Asp Gly Leu Leu Gly 
145                 150                 155                 160 


Asp Ile Leu Gln Asp Leu Asn Thr Glu Thr Pro Gln Ile Thr Pro Pro 
                165                 170                 175     


Pro Val Met Ile Leu Lys Lys Lys Arg Ser Ile Gly Ala Ser Pro Asn 
            180                 185                 190         


Pro Phe Ser Val His Thr Ala Thr Ala Val Pro Ser Gly Lys Ile Ala 
        195                 200                 205             


Ser Pro Val Ser Arg Lys Glu Pro Pro Leu Thr Pro Val Pro Leu Lys 
    210                 215                 220                 


Arg Ala Glu Phe Ala Gly Asp Asp Val Gln Val Glu Ser Thr Glu Glu 
225                 230                 235                 240 


Glu Gln Glu Ser Gly Ala Met Glu Phe Glu Asp Gly Asp Phe Asp Glu 
                245                 250                 255     


Pro Met Glu Val Glu Glu Val Asp Leu Glu Pro Met Ala Ala Lys Ala 
            260                 265                 270         


Trp Asp Lys Glu Ser Glu Pro Ala Glu Glu Val Lys Gln Glu Ala Asp 
        275                 280                 285             


Ser Gly Lys Gly Thr Val Ser Tyr Leu Gly Ser Phe Leu Pro Asp Val 
    290                 295                 300                 


Ser Cys Trp Asp Ile Asp Gln Glu Gly Asp Ser Ser Phe Ser Val Gln 
305                 310                 315                 320 


Glu Val Gln Val Asp Ser Ser His Leu Pro Leu Val Lys Gly Ala Asp 
                325                 330                 335     


Glu Glu Gln Val Phe His Phe Tyr Trp Leu Asp Ala Tyr Glu Asp Gln 
            340                 345                 350         


Tyr Asn Gln Pro Gly Val Val Phe Leu Phe Gly Lys Val Trp Ile Glu 
        355                 360                 365             


Ser Ala Glu Thr His Val Ser Cys Cys Val Met Val Lys Asn Ile Glu 
    370                 375                 380                 


Arg Thr Leu Tyr Phe Leu Pro Arg Glu Met Lys Ile Asp Leu Asn Thr 
385                 390                 395                 400 


Gly Lys Glu Thr Gly Thr Pro Ile Ser Met Lys Asp Val Tyr Glu Glu 
                405                 410                 415     


Phe Asp Glu Lys Ile Ala Thr Lys Tyr Lys Ile Met Lys Phe Lys Ser 
            420                 425                 430         


Lys Pro Val Glu Lys Asn Tyr Ala Phe Glu Ile Pro Asp Val Pro Glu 
        435                 440                 445             


Lys Ser Glu Tyr Leu Glu Val Lys Tyr Ser Ala Glu Met Pro Gln Leu 
    450                 455                 460                 


Pro Gln Asp Leu Lys Gly Glu Thr Phe Ser His Val Phe Gly Thr Asn 
465                 470                 475                 480 


Thr Ser Ser Leu Glu Leu Phe Leu Met Asn Arg Lys Ile Lys Gly Pro 
                485                 490                 495     


Cys Trp Leu Glu Val Lys Ser Pro Gln Leu Leu Asn Gln Pro Val Ser 
            500                 505                 510         


Trp Cys Lys Val Glu Ala Met Ala Leu Lys Pro Asp Leu Val Asn Val 
        515                 520                 525             


Ile Lys Asp Val Ser Pro Pro Pro Leu Val Val Met Ala Phe Ser Met 
    530                 535                 540                 


Lys Thr Met Gln Asn Ala Lys Asn His Gln Asn Glu Ile Ile Ala Met 
545                 550                 555                 560 


Ala Ala Leu Val His His Ser Phe Ala Leu Asp Lys Ala Ala Pro Lys 
                565                 570                 575     


Pro Pro Phe Gln Ser His Phe Cys Val Val Ser Lys Pro Lys Asp Cys 
            580                 585                 590         


Ile Phe Pro Tyr Ala Phe Lys Glu Val Ile Glu Lys Lys Asn Val Lys 
        595                 600                 605             


Val Glu Val Ala Ala Thr Glu Arg Thr Leu Leu Gly Phe Phe Leu Ala 
    610                 615                 620                 


Lys Val His Lys Ile Asp Pro Asp Ile Ile Val Gly His Asn Ile Tyr 
625                 630                 635                 640 


Gly Phe Glu Leu Glu Val Leu Leu Gln Arg Ile Asn Val Cys Lys Ala 
                645                 650                 655     


Pro His Trp Ser Lys Ile Gly Arg Leu Lys Arg Ser Asn Met Pro Lys 
            660                 665                 670         


Leu Gly Gly Arg Ser Gly Phe Gly Glu Arg Asn Ala Thr Cys Gly Arg 
        675                 680                 685             


Met Ile Cys Asp Val Glu Ile Ser Ala Lys Glu Leu Ile Arg Cys Lys 
    690                 695                 700                 


Ser Tyr His Leu Ser Glu Leu Val Gln Gln Ile Leu Lys Thr Glu Arg 
705                 710                 715                 720 


Val Val Ile Pro Met Glu Asn Ile Gln Asn Met Tyr Ser Glu Ser Ser 
                725                 730                 735     


Gln Leu Leu Tyr Leu Leu Glu His Thr Trp Lys Asp Ala Lys Phe Ile 
            740                 745                 750         


Leu Gln Ile Met Cys Glu Leu Asn Val Leu Pro Leu Ala Leu Gln Ile 
        755                 760                 765             


Thr Asn Ile Ala Gly Asn Ile Met Ser Arg Thr Leu Met Gly Gly Arg 
    770                 775                 780                 


Ser Glu Arg Asn Glu Phe Leu Leu Leu His Ala Phe Tyr Glu Asn Asn 
785                 790                 795                 800 


Tyr Ile Val Pro Asp Lys Gln Ile Phe Arg Lys Pro Gln Gln Lys Leu 
                805                 810                 815     


Gly Asp Glu Asp Glu Glu Ile Asp Gly Asp Thr Asn Lys Tyr Lys Lys 
            820                 825                 830         


Gly Arg Lys Lys Ala Ala Tyr Ala Gly Gly Leu Val Leu Asp Pro Lys 
        835                 840                 845             


Val Gly Phe Tyr Asp Lys Phe Ile Leu Leu Leu Asp Phe Asn Ser Leu 
    850                 855                 860                 


Tyr Pro Ser Ile Ile Gln Glu Phe Asn Ile Cys Phe Thr Thr Val Gln 
865                 870                 875                 880 


Arg Val Ala Ser Glu Ala Gln Lys Val Thr Glu Asp Gly Glu Gln Glu 
                885                 890                 895     


Gln Ile Pro Glu Leu Pro Asp Pro Ser Leu Glu Met Gly Ile Leu Pro 
            900                 905                 910         


Arg Glu Ile Arg Lys Leu Val Glu Arg Arg Lys Gln Val Lys Gln Leu 
        915                 920                 925             


Met Lys Gln Gln Asp Leu Asn Pro Asp Leu Ile Leu Gln Tyr Asp Ile 
    930                 935                 940                 


Arg Gln Lys Ala Leu Lys Leu Thr Ala Asn Ser Met Tyr Gly Cys Leu 
945                 950                 955                 960 


Gly Phe Ser Tyr Ser Arg Phe Tyr Ala Lys Pro Leu Ala Ala Leu Val 
                965                 970                 975     


Thr Tyr Lys Gly Arg Glu Ile Leu Met His Thr Lys Glu Met Val Gln 
            980                 985                 990         


Lys Met Asn Leu Glu Val Ile Tyr  Gly Asp Thr Asp Ser  Ile Met Ile 
        995                 1000                 1005             


Asn Thr  Asn Ser Thr Asn Leu  Glu Glu Val Phe Lys  Leu Gly Asn 
    1010                 1015                 1020             


Lys Val  Lys Ser Glu Val Asn  Lys Leu Tyr Lys Leu  Leu Glu Ile 
    1025                 1030                 1035             


Asp Ile  Asp Gly Val Phe Lys  Ser Leu Leu Leu Leu  Lys Lys Lys 
    1040                 1045                 1050             


Lys Tyr  Ala Ala Leu Val Val  Glu Pro Thr Ser Asp  Gly Asn Tyr 
    1055                 1060                 1065             


Val Thr  Lys Gln Glu Leu Lys  Gly Leu Asp Ile Val  Arg Arg Asp 
    1070                 1075                 1080             


Trp Cys  Asp Leu Ala Lys Asp  Thr Gly Asn Phe Val  Ile Gly Gln 
    1085                 1090                 1095             


Ile Leu  Ser Asp Gln Ser Arg  Asp Thr Ile Val Glu  Asn Ile Gln 
    1100                 1105                 1110             


Lys Arg  Leu Ile Glu Ile Gly  Glu Asn Val Leu Asn  Gly Ser Val 
    1115                 1120                 1125             


Pro Val  Ser Gln Phe Glu Ile  Asn Lys Ala Leu Thr  Lys Asp Pro 
    1130                 1135                 1140             


Gln Asp  Tyr Pro Asp Lys Lys  Ser Leu Pro His Val  His Val Ala 
    1145                 1150                 1155             


Leu Trp  Ile Asn Ser Gln Gly  Gly Arg Lys Val Lys  Ala Gly Asp 
    1160                 1165                 1170             


Thr Val  Ser Tyr Val Ile Cys  Gln Asp Gly Ser Asn  Leu Thr Ala 
    1175                 1180                 1185             


Ser Gln  Arg Ala Tyr Ala Pro  Glu Gln Leu Gln Lys  Gln Asp Asn 
    1190                 1195                 1200             


Leu Thr  Ile Asp Thr Gln Tyr  Tyr Leu Ala Gln Gln  Ile His Pro 
    1205                 1210                 1215             


Val Val  Ala Arg Ile Cys Glu  Pro Ile Asp Gly Ile  Asp Ala Val 
    1220                 1225                 1230             


Leu Ile  Ala Thr Trp Leu Gly  Leu Asp Pro Thr Gln  Phe Arg Val 
    1235                 1240                 1245             


His His  Tyr His Lys Asp Glu  Glu Asn Asp Ala Leu  Leu Gly Gly 
    1250                 1255                 1260             


Pro Ala  Gln Leu Thr Asp Glu  Glu Lys Tyr Arg Asp  Cys Glu Arg 
    1265                 1270                 1275             


Phe Lys  Cys Pro Cys Pro Thr  Cys Gly Thr Glu Asn  Ile Tyr Asp 
    1280                 1285                 1290             


Asn Val  Phe Asp Gly Ser Gly  Thr Asp Met Glu Pro  Ser Leu Tyr 
    1295                 1300                 1305             


Arg Cys  Ser Asn Ile Asp Cys  Lys Ala Ser Pro Leu  Thr Phe Thr 
    1310                 1315                 1320             


Val Gln  Leu Ser Asn Lys Leu  Ile Met Asp Ile Arg  Arg Phe Ile 
    1325                 1330                 1335             


Lys Lys  Tyr Tyr Asp Gly Trp  Leu Ile Cys Glu Glu  Pro Thr Cys 
    1340                 1345                 1350             


Arg Asn  Arg Thr Arg His Leu  Pro Leu Gln Phe Ser  Arg Thr Gly 
    1355                 1360                 1365             


Pro Leu  Cys Pro Ala Cys Met  Lys Ala Thr Leu Gln  Pro Glu Tyr 
    1370                 1375                 1380             


Ser Asp  Lys Ser Leu Tyr Thr  Gln Leu Cys Phe Tyr  Arg Tyr Ile 
    1385                 1390                 1395             


Phe Asp  Ala Glu Cys Ala Leu  Glu Lys Leu Thr Thr  Asp His Glu 
    1400                 1405                 1410             


Lys Asp  Lys Leu Lys Lys Gln  Phe Phe Thr Pro Lys  Val Leu Gln 
    1415                 1420                 1425             


Asp Tyr  Arg Lys Leu Lys Asn  Thr Ala Glu Gln Phe  Leu Ser Arg 
    1430                 1435                 1440             


Ser Gly  Tyr Ser Glu Val Asn  Leu Ser Lys Leu Phe  Ala Gly Cys 
    1445                 1450                 1455             


Ala Val  Lys Ser 
    1460         


<210>  50
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly 
    130                 135                 140                 


Asp Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp 
145                 150                 155                 160 


Ile Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr 
                165                 170                 175     


Val Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp 
            180                 185                 190         


Val Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro 
        195                 200                 205             


Lys Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile 
    210                 215                 220                 


Thr Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln 
225                 230                 235                 240 


Leu Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp 
                245                 250                 255     


Ile Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe 
            260                 265                 270         


Thr Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu 
        275                 280                 285             


Lys Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr 
    290                 295                 300                 


Gly Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe 
305                 310                 315                 320 


Asp Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                325                 330                 335 


<210>  51
<211>  1239
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Arg Leu Leu Trp Arg Lys Val Ala Gly Ala Thr Val Gly Pro 
1               5                   10                  15      


Gly Pro Val Pro Ala Pro Gly Arg Trp Val Ser Ser Ser Val Pro Ala 
            20                  25                  30          


Ser Asp Pro Ser Asp Gly Gln Arg Arg Arg Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Pro Gln Val Leu Ser Ser 
    50                  55                  60                  


Glu Gly Gly Gln Leu Arg His Asn Pro Leu Asp Ile Gln Met Leu Ser 
65                  70                  75                  80  


Arg Gly Leu His Glu Gln Ile Phe Gly Gln Gly Gly Glu Met Pro Gly 
                85                  90                  95      


Glu Ala Ala Val Arg Arg Ser Val Glu His Leu Gln Lys His Gly Leu 
            100                 105                 110         


Trp Gly Gln Pro Ala Val Pro Leu Pro Asp Val Glu Leu Arg Leu Pro 
        115                 120                 125             


Pro Leu Tyr Gly Asp Asn Leu Asp Gln His Phe Arg Leu Leu Ala Gln 
    130                 135                 140                 


Lys Gln Ser Leu Pro Tyr Leu Glu Ala Ala Asn Leu Leu Leu Gln Ala 
145                 150                 155                 160 


Gln Leu Pro Pro Lys Pro Pro Ala Trp Ala Trp Ala Glu Gly Trp Thr 
                165                 170                 175     


Arg Tyr Gly Pro Glu Gly Glu Ala Val Pro Val Ala Ile Pro Glu Glu 
            180                 185                 190         


Arg Ala Leu Val Phe Asp Val Glu Val Cys Leu Ala Glu Gly Thr Cys 
        195                 200                 205             


Pro Thr Leu Ala Val Ala Ile Ser Pro Ser Ala Trp Tyr Ser Trp Cys 
    210                 215                 220                 


Ser Gln Arg Leu Val Glu Glu Arg Tyr Ser Trp Thr Ser Gln Leu Ser 
225                 230                 235                 240 


Pro Ala Asp Leu Ile Pro Leu Glu Val Pro Thr Gly Ala Ser Ser Pro 
                245                 250                 255     


Thr Gln Arg Asp Trp Gln Glu Gln Leu Val Val Gly His Asn Val Ser 
            260                 265                 270         


Phe Asp Arg Ala His Ile Arg Glu Gln Tyr Leu Ile Gln Gly Ser Arg 
        275                 280                 285             


Met Arg Phe Leu Asp Thr Met Ser Met His Met Ala Ile Ser Gly Leu 
    290                 295                 300                 


Ser Ser Phe Gln Arg Ser Leu Trp Ile Ala Ala Lys Gln Gly Lys His 
305                 310                 315                 320 


Lys Val Gln Pro Pro Thr Lys Gln Gly Gln Lys Ser Gln Arg Lys Ala 
                325                 330                 335     


Arg Arg Gly Pro Ala Ile Ser Ser Trp Asp Trp Leu Asp Ile Ser Ser 
            340                 345                 350         


Val Asn Ser Leu Ala Glu Val His Arg Leu Tyr Val Gly Gly Pro Pro 
        355                 360                 365             


Leu Glu Lys Glu Pro Arg Glu Leu Phe Val Lys Gly Thr Met Lys Asp 
    370                 375                 380                 


Ile Arg Glu Asn Phe Gln Asp Leu Met Gln Tyr Cys Ala Gln Asp Val 
385                 390                 395                 400 


Trp Ala Thr His Glu Val Phe Gln Gln Gln Leu Pro Leu Phe Leu Glu 
                405                 410                 415     


Arg Cys Pro His Pro Val Thr Leu Ala Gly Met Leu Glu Met Gly Val 
            420                 425                 430         


Ser Tyr Leu Pro Val Asn Gln Asn Trp Glu Arg Tyr Leu Ala Glu Ala 
        435                 440                 445             


Gln Gly Thr Tyr Glu Glu Leu Gln Arg Glu Met Lys Lys Ser Leu Met 
    450                 455                 460                 


Asp Leu Ala Asn Asp Ala Cys Gln Leu Leu Ser Gly Glu Arg Tyr Lys 
465                 470                 475                 480 


Glu Asp Pro Trp Leu Trp Asp Leu Glu Trp Asp Leu Gln Glu Phe Lys 
                485                 490                 495     


Gln Lys Lys Ala Lys Lys Val Lys Lys Glu Pro Ala Thr Ala Ser Lys 
            500                 505                 510         


Leu Pro Ile Glu Gly Ala Gly Ala Pro Gly Asp Pro Met Asp Gln Glu 
        515                 520                 525             


Asp Leu Gly Pro Cys Ser Glu Glu Glu Glu Phe Gln Gln Asp Val Met 
    530                 535                 540                 


Ala Arg Ala Cys Leu Gln Lys Leu Lys Gly Thr Thr Glu Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Pro Gln His Leu Pro Gly His Pro Gly Trp Tyr Arg Lys Leu 
                565                 570                 575     


Cys Pro Arg Leu Asp Asp Pro Ala Trp Thr Pro Gly Pro Ser Leu Leu 
            580                 585                 590         


Ser Leu Gln Met Arg Val Thr Pro Lys Leu Met Ala Leu Thr Trp Asp 
        595                 600                 605             


Gly Phe Pro Leu His Tyr Ser Glu Arg His Gly Trp Gly Tyr Leu Val 
    610                 615                 620                 


Pro Gly Arg Arg Asp Asn Leu Ala Lys Leu Pro Thr Gly Thr Thr Leu 
625                 630                 635                 640 


Glu Ser Ala Gly Val Val Cys Pro Tyr Arg Ala Ile Glu Ser Leu Tyr 
                645                 650                 655     


Arg Lys His Cys Leu Glu Gln Gly Lys Gln Gln Leu Met Pro Gln Glu 
            660                 665                 670         


Ala Gly Leu Ala Glu Glu Phe Leu Leu Thr Asp Asn Ser Ala Ile Trp 
        675                 680                 685             


Gln Thr Val Glu Glu Leu Asp Tyr Leu Glu Val Glu Ala Glu Ala Lys 
    690                 695                 700                 


Met Glu Asn Leu Arg Ala Ala Val Pro Gly Gln Pro Leu Ala Leu Thr 
705                 710                 715                 720 


Ala Arg Gly Gly Pro Lys Asp Thr Gln Pro Ser Tyr His His Gly Asn 
                725                 730                 735     


Gly Pro Tyr Asn Asp Val Asp Ile Pro Gly Cys Trp Phe Phe Lys Leu 
            740                 745                 750         


Pro His Lys Asp Gly Asn Ser Cys Asn Val Gly Ser Pro Phe Ala Lys 
        755                 760                 765             


Asp Phe Leu Pro Lys Met Glu Asp Gly Thr Leu Gln Ala Gly Pro Gly 
    770                 775                 780                 


Gly Ala Ser Gly Pro Arg Ala Leu Glu Ile Asn Lys Met Ile Ser Phe 
785                 790                 795                 800 


Trp Arg Asn Ala His Lys Arg Ile Ser Ser Gln Met Val Val Trp Leu 
                805                 810                 815     


Pro Arg Ser Ala Leu Pro Arg Ala Val Ile Arg His Pro Asp Tyr Asp 
            820                 825                 830         


Glu Glu Gly Leu Tyr Gly Ala Ile Leu Pro Gln Val Val Thr Ala Gly 
        835                 840                 845             


Thr Ile Thr Arg Arg Ala Val Glu Pro Thr Trp Leu Thr Ala Ser Asn 
    850                 855                 860                 


Ala Arg Pro Asp Arg Val Gly Ser Glu Leu Lys Ala Met Val Gln Ala 
865                 870                 875                 880 


Pro Pro Gly Tyr Thr Leu Val Gly Ala Asp Val Asp Ser Gln Glu Leu 
                885                 890                 895     


Trp Ile Ala Ala Val Leu Gly Asp Ala His Phe Ala Gly Met His Gly 
            900                 905                 910         


Cys Thr Ala Phe Gly Trp Met Thr Leu Gln Gly Arg Lys Ser Arg Gly 
        915                 920                 925             


Thr Asp Leu His Ser Lys Thr Ala Thr Thr Val Gly Ile Ser Arg Glu 
    930                 935                 940                 


His Ala Lys Ile Phe Asn Tyr Gly Arg Ile Tyr Gly Ala Gly Gln Pro 
945                 950                 955                 960 


Phe Ala Glu Arg Leu Leu Met Gln Phe Asn His Arg Leu Thr Gln Gln 
                965                 970                 975     


Glu Ala Ala Glu Lys Ala Gln Gln Met Tyr Ala Ala Thr Lys Gly Leu 
            980                 985                 990         


Arg Trp Tyr Arg Leu Ser Asp Glu  Gly Glu Trp Leu Val  Arg Glu Leu 
        995                 1000                 1005             


Asn Leu  Pro Val Asp Arg Thr  Glu Gly Gly Trp Ile  Ser Leu Gln 
    1010                 1015                 1020             


Asp Leu  Arg Lys Val Gln Arg  Glu Thr Ala Arg Lys  Ser Gln Trp 
    1025                 1030                 1035             


Lys Lys  Trp Glu Val Val Ala  Glu Arg Ala Trp Lys  Gly Gly Thr 
    1040                 1045                 1050             


Glu Ser  Glu Met Phe Asn Lys  Leu Glu Ser Ile Ala  Thr Ser Asp 
    1055                 1060                 1065             


Ile Pro  Arg Thr Pro Val Leu  Gly Cys Cys Ile Ser  Arg Ala Leu 
    1070                 1075                 1080             


Glu Pro  Ser Ala Val Gln Glu  Glu Phe Met Thr Ser  Arg Val Asn 
    1085                 1090                 1095             


Trp Val  Val Gln Ser Ser Ala  Val Asp Tyr Leu His  Leu Met Leu 
    1100                 1105                 1110             


Val Ala  Met Lys Trp Leu Phe  Glu Glu Phe Ala Ile  Asp Gly Arg 
    1115                 1120                 1125             


Phe Cys  Ile Ser Ile His Asp  Glu Val Arg Tyr Leu  Val Arg Glu 
    1130                 1135                 1140             


Glu Asp  Arg Tyr Arg Ala Ala  Leu Ala Leu Gln Ile  Thr Asn Leu 
    1145                 1150                 1155             


Leu Thr  Arg Cys Met Phe Ala  Tyr Lys Leu Gly Leu  Asn Asp Leu 
    1160                 1165                 1170             


Pro Gln  Ser Val Ala Phe Phe  Ser Ala Val Asp Ile  Asp Arg Cys 
    1175                 1180                 1185             


Leu Arg  Lys Glu Val Thr Met  Asp Cys Lys Thr Pro  Ser Asn Pro 
    1190                 1195                 1200             


Thr Gly  Met Glu Arg Arg Tyr  Gly Ile Pro Gln Gly  Glu Ala Leu 
    1205                 1210                 1215             


Asp Ile  Tyr Gln Ile Ile Glu  Leu Thr Lys Gly Ser  Leu Glu Lys 
    1220                 1225                 1230             


Arg Ser  Gln Pro Gly Pro 
    1235                 


<210>  52
<211>  1187
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  52

Met Met Phe Gly Lys Lys Lys Asn Asn Gly Gly Ser Ser Thr Ala Arg 
1               5                   10                  15      


Tyr Ser Ala Gly Asn Lys Tyr Asn Thr Leu Ser Asn Asn Tyr Ala Leu 
            20                  25                  30          


Ser Ala Gln Gln Leu Leu Asn Ala Ser Lys Ile Asp Asp Ile Asp Ser 
        35                  40                  45              


Met Met Gly Phe Glu Arg Tyr Val Pro Pro Gln Tyr Asn Gly Arg Phe 
    50                  55                  60                  


Asp Ala Lys Asp Ile Asp Gln Ile Pro Gly Arg Val Gly Trp Leu Thr 
65                  70                  75                  80  


Asn Met His Ala Thr Leu Val Ser Gln Glu Thr Leu Ser Ser Gly Ser 
                85                  90                  95      


Asn Gly Gly Gly Asn Ser Asn Asp Gly Glu Arg Val Thr Thr Asn Gln 
            100                 105                 110         


Gly Ile Ser Gly Val Asp Phe Tyr Phe Leu Asp Glu Glu Gly Gly Ser 
        115                 120                 125             


Phe Lys Ser Thr Val Val Tyr Asp Pro Tyr Phe Phe Ile Ala Cys Asn 
    130                 135                 140                 


Asp Glu Ser Arg Val Asn Asp Val Glu Glu Leu Val Lys Lys Tyr Leu 
145                 150                 155                 160 


Glu Ser Cys Leu Lys Ser Leu Gln Ile Ile Arg Lys Glu Asp Leu Thr 
                165                 170                 175     


Met Asp Asn His Leu Leu Gly Leu Gln Lys Thr Leu Ile Lys Leu Ser 
            180                 185                 190         


Phe Val Asn Ser Asn Gln Leu Phe Glu Ala Arg Lys Leu Leu Arg Pro 
        195                 200                 205             


Ile Leu Gln Asp Asn Ala Asn Asn Asn Val Gln Arg Asn Ile Tyr Asn 
    210                 215                 220                 


Val Ala Ala Asn Gly Ser Glu Lys Val Asp Ala Lys His Leu Ile Glu 
225                 230                 235                 240 


Asp Ile Arg Glu Tyr Asp Val Pro Tyr His Val Arg Val Ser Ile Asp 
                245                 250                 255     


Lys Asp Ile Arg Val Gly Lys Trp Tyr Lys Val Thr Gln Gln Gly Phe 
            260                 265                 270         


Ile Glu Asp Thr Arg Lys Ile Ala Phe Ala Asp Pro Val Val Met Ala 
        275                 280                 285             


Phe Asp Ile Glu Thr Thr Lys Pro Pro Leu Lys Phe Pro Asp Ser Ala 
    290                 295                 300                 


Val Asp Gln Ile Met Met Ile Ser Tyr Met Ile Asp Gly Glu Gly Phe 
305                 310                 315                 320 


Leu Ile Thr Asn Arg Glu Ile Ile Ser Glu Asp Ile Glu Asp Phe Glu 
                325                 330                 335     


Tyr Thr Pro Lys Pro Glu Tyr Pro Gly Phe Phe Thr Ile Phe Asn Glu 
            340                 345                 350         


Asn Asp Glu Val Ala Leu Leu Gln Arg Phe Phe Glu His Ile Arg Asp 
        355                 360                 365             


Val Arg Pro Thr Val Ile Ser Thr Phe Asn Gly Asp Phe Phe Asp Trp 
    370                 375                 380                 


Pro Phe Ile His Asn Arg Ser Lys Ile His Gly Leu Asp Met Phe Asp 
385                 390                 395                 400 


Glu Ile Gly Phe Ala Pro Asp Ala Glu Gly Glu Tyr Lys Ser Ser Tyr 
                405                 410                 415     


Cys Ser His Met Asp Cys Phe Arg Trp Val Lys Arg Asp Ser Tyr Leu 
            420                 425                 430         


Pro Gln Gly Ser Gln Gly Leu Lys Ala Val Thr Gln Ser Lys Leu Gly 
        435                 440                 445             


Tyr Asn Pro Ile Glu Leu Asp Pro Glu Leu Met Thr Pro Tyr Ala Phe 
    450                 455                 460                 


Glu Lys Pro Gln His Leu Ser Glu Tyr Ser Val Ser Asp Ala Val Ala 
465                 470                 475                 480 


Thr Tyr Tyr Leu Tyr Met Lys Tyr Val His Pro Phe Ile Phe Ser Leu 
                485                 490                 495     


Cys Thr Ile Ile Pro Leu Asn Pro Asp Glu Thr Leu Arg Lys Gly Thr 
            500                 505                 510         


Gly Thr Leu Cys Glu Met Leu Leu Met Val Gln Ala Tyr Gln His Asn 
        515                 520                 525             


Ile Leu Leu Pro Asn Lys His Thr Asp Pro Ile Glu Arg Phe Tyr Asp 
    530                 535                 540                 


Gly His Leu Leu Glu Ser Glu Thr Tyr Val Gly Gly His Val Glu Ser 
545                 550                 555                 560 


Leu Glu Ala Gly Val Phe Arg Ser Asp Leu Lys Asn Glu Phe Lys Ile 
                565                 570                 575     


Asp Pro Ser Ala Ile Asp Glu Leu Leu Gln Glu Leu Pro Glu Ala Leu 
            580                 585                 590         


Lys Phe Ser Val Glu Val Glu Asn Lys Ser Ser Val Asp Lys Val Thr 
        595                 600                 605             


Asn Phe Glu Glu Ile Lys Asn Gln Ile Thr Gln Lys Leu Leu Glu Leu 
    610                 615                 620                 


Lys Glu Asn Asn Ile Arg Asn Glu Leu Pro Leu Ile Tyr His Val Asp 
625                 630                 635                 640 


Val Ala Ser Met Tyr Pro Asn Ile Met Thr Thr Asn Arg Leu Gln Pro 
                645                 650                 655     


Asp Ser Ile Lys Ala Glu Arg Asp Cys Ala Ser Cys Asp Phe Asn Arg 
            660                 665                 670         


Pro Gly Lys Thr Cys Ala Arg Lys Leu Lys Trp Ala Trp Arg Gly Glu 
        675                 680                 685             


Phe Phe Pro Ser Lys Met Asp Glu Tyr Asn Met Ile Lys Arg Ala Leu 
    690                 695                 700                 


Gln Asn Glu Thr Phe Pro Asn Lys Asn Lys Phe Ser Lys Lys Lys Val 
705                 710                 715                 720 


Leu Thr Phe Asp Glu Leu Ser Tyr Ala Asp Gln Val Ile His Ile Lys 
                725                 730                 735     


Lys Arg Leu Thr Glu Tyr Ser Arg Lys Val Tyr His Arg Val Lys Val 
            740                 745                 750         


Ser Glu Ile Val Glu Arg Glu Ala Ile Val Cys Gln Arg Glu Asn Pro 
        755                 760                 765             


Phe Tyr Val Asp Thr Val Lys Ser Phe Arg Asp Arg Arg Tyr Glu Phe 
    770                 775                 780                 


Lys Gly Leu Ala Lys Thr Trp Lys Gly Asn Leu Ser Lys Ile Asp Pro 
785                 790                 795                 800 


Ser Asp Lys His Ala Arg Asp Glu Ala Lys Lys Met Ile Val Leu Tyr 
                805                 810                 815     


Asp Ser Leu Gln Leu Ala His Lys Val Ile Leu Asn Ser Phe Tyr Gly 
            820                 825                 830         


Tyr Val Met Arg Lys Gly Ser Arg Trp Tyr Ser Met Glu Met Ala Gly 
        835                 840                 845             


Ile Thr Cys Leu Thr Gly Ala Thr Ile Ile Gln Met Ala Arg Ala Leu 
    850                 855                 860                 


Val Glu Arg Val Gly Arg Pro Leu Glu Leu Asp Thr Asp Gly Ile Trp 
865                 870                 875                 880 


Cys Ile Leu Pro Lys Ser Phe Pro Glu Thr Tyr Phe Phe Thr Leu Glu 
                885                 890                 895     


Asn Gly Lys Lys Leu Tyr Leu Ser Tyr Pro Cys Ser Met Leu Asn Tyr 
            900                 905                 910         


Arg Val His Gln Lys Phe Thr Asn His Gln Tyr Gln Glu Leu Lys Asp 
        915                 920                 925             


Pro Leu Asn Tyr Ile Tyr Glu Thr His Ser Glu Asn Thr Ile Phe Phe 
    930                 935                 940                 


Glu Val Asp Gly Pro Tyr Lys Ala Met Ile Leu Pro Ser Ser Lys Glu 
945                 950                 955                 960 


Glu Gly Lys Gly Ile Lys Lys Arg Tyr Ala Val Phe Asn Glu Asp Gly 
                965                 970                 975     


Ser Leu Ala Glu Leu Lys Gly Phe Glu Leu Lys Arg Arg Gly Glu Leu 
            980                 985                 990         


Gln Leu Ile Lys Asn Phe Gln Ser  Asp Ile Phe Lys Val  Phe Leu Glu 
        995                 1000                 1005             


Gly Asp  Thr Leu Glu Gly Cys  Tyr Ser Ala Val Ala  Ser Val Cys 
    1010                 1015                 1020             


Asn Arg  Trp Leu Asp Val Leu  Asp Ser His Gly Leu  Met Leu Glu 
    1025                 1030                 1035             


Asp Glu  Asp Leu Val Ser Leu  Ile Cys Glu Asn Arg  Ser Met Ser 
    1040                 1045                 1050             


Lys Thr  Leu Lys Glu Tyr Glu  Gly Gln Lys Ser Thr  Ser Ile Thr 
    1055                 1060                 1065             


Thr Ala  Arg Arg Leu Gly Asp  Phe Leu Gly Glu Asp  Met Val Lys 
    1070                 1075                 1080             


Asp Lys  Gly Leu Gln Cys Lys  Tyr Ile Ile Ser Ser  Lys Pro Phe 
    1085                 1090                 1095             


Asn Ala  Pro Val Thr Glu Arg  Ala Ile Pro Val Ala  Ile Phe Ser 
    1100                 1105                 1110             


Ala Asp  Ile Pro Ile Lys Arg  Ser Phe Leu Arg Arg  Trp Thr Leu 
    1115                 1120                 1125             


Asp Pro  Ser Leu Glu Asp Leu  Asp Ile Arg Thr Ile  Ile Asp Trp 
    1130                 1135                 1140             


Gly Tyr  Tyr Arg Glu Arg Leu  Gly Ser Ala Ile Gln  Lys Ile Ile 
    1145                 1150                 1155             


Thr Ile  Pro Ala Ala Leu Gln  Gly Val Ser Asn Pro  Val Pro Arg 
    1160                 1165                 1170             


Val Glu  His Pro Asp Trp Leu  Lys Arg Lys Ile Ala  Thr Lys 
    1175                 1180                 1185         


<210>  53
<211>  632
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  53

Met Ser Lys Phe Thr Trp Lys Glu Leu Ile Gln Leu Gly Ser Pro Ser 
1               5                   10                  15      


Lys Ala Tyr Glu Ser Ser Leu Ala Cys Ile Ala His Ile Asp Met Asn 
            20                  25                  30          


Ala Phe Phe Ala Gln Val Glu Gln Met Arg Cys Gly Leu Ser Lys Glu 
        35                  40                  45              


Asp Pro Val Val Cys Val Gln Trp Asn Ser Ile Ile Ala Val Ser Tyr 
    50                  55                  60                  


Ala Ala Arg Lys Tyr Gly Ile Ser Arg Met Asp Thr Ile Gln Glu Ala 
65                  70                  75                  80  


Leu Lys Lys Cys Ser Asn Leu Ile Pro Ile His Thr Ala Val Phe Lys 
                85                  90                  95      


Lys Gly Glu Asp Phe Trp Gln Tyr His Asp Gly Cys Gly Ser Trp Val 
            100                 105                 110         


Gln Asp Pro Ala Lys Gln Ile Ser Val Glu Asp His Lys Val Ser Leu 
        115                 120                 125             


Glu Pro Tyr Arg Arg Glu Ser Arg Lys Ala Leu Lys Ile Phe Lys Ser 
    130                 135                 140                 


Ala Cys Asp Leu Val Glu Arg Ala Ser Ile Asp Glu Val Phe Leu Asp 
145                 150                 155                 160 


Leu Gly Arg Ile Cys Phe Asn Met Leu Met Phe Asp Asn Glu Tyr Glu 
                165                 170                 175     


Leu Thr Gly Asp Leu Lys Leu Lys Asp Ala Leu Ser Asn Ile Arg Glu 
            180                 185                 190         


Ala Phe Ile Gly Gly Asn Tyr Asp Ile Asn Ser His Leu Pro Leu Ile 
        195                 200                 205             


Pro Glu Lys Ile Lys Ser Leu Lys Phe Glu Gly Asp Val Phe Asn Pro 
    210                 215                 220                 


Glu Gly Arg Asp Leu Ile Thr Asp Trp Asp Asp Val Ile Leu Ala Leu 
225                 230                 235                 240 


Gly Ser Gln Val Cys Lys Gly Ile Arg Asp Ser Ile Lys Asp Ile Leu 
                245                 250                 255     


Gly Tyr Thr Thr Ser Cys Gly Leu Ser Ser Thr Lys Asn Val Cys Lys 
            260                 265                 270         


Leu Ala Ser Asn Tyr Lys Lys Pro Asp Ala Gln Thr Ile Val Lys Asn 
        275                 280                 285             


Asp Cys Leu Leu Asp Phe Leu Asp Cys Gly Lys Phe Glu Ile Thr Ser 
    290                 295                 300                 


Phe Trp Thr Leu Gly Gly Val Leu Gly Lys Glu Leu Ile Asp Val Leu 
305                 310                 315                 320 


Asp Leu Pro His Glu Asn Ser Ile Lys His Ile Arg Glu Thr Trp Pro 
                325                 330                 335     


Asp Asn Ala Gly Gln Leu Lys Glu Phe Leu Asp Ala Lys Val Lys Gln 
            340                 345                 350         


Ser Asp Tyr Asp Arg Ser Thr Ser Asn Ile Asp Pro Leu Lys Thr Ala 
        355                 360                 365             


Asp Leu Ala Glu Lys Leu Phe Lys Leu Ser Arg Gly Arg Tyr Gly Leu 
    370                 375                 380                 


Pro Leu Ser Ser Arg Pro Val Val Lys Ser Met Met Ser Asn Lys Asn 
385                 390                 395                 400 


Leu Arg Gly Lys Ser Cys Asn Ser Ile Val Asp Cys Ile Ser Trp Leu 
                405                 410                 415     


Glu Val Phe Cys Ala Glu Leu Thr Ser Arg Ile Gln Asp Leu Glu Gln 
            420                 425                 430         


Glu Tyr Asn Lys Ile Val Ile Pro Arg Thr Val Ser Ile Ser Leu Lys 
        435                 440                 445             


Thr Lys Ser Tyr Glu Val Tyr Arg Lys Ser Gly Pro Val Ala Tyr Lys 
    450                 455                 460                 


Gly Ile Asn Phe Gln Ser His Glu Leu Leu Lys Val Gly Ile Lys Phe 
465                 470                 475                 480 


Val Thr Asp Leu Asp Ile Lys Gly Lys Asn Lys Ser Tyr Tyr Pro Leu 
                485                 490                 495     


Thr Lys Leu Ser Met Thr Ile Thr Asn Phe Asp Ile Ile Asp Leu Gln 
            500                 505                 510         


Lys Thr Val Val Asp Met Phe Gly Asn Gln Val His Thr Phe Lys Ser 
        515                 520                 525             


Ser Ala Gly Lys Glu Asp Glu Glu Lys Thr Thr Ser Ser Lys Ala Asp 
    530                 535                 540                 


Glu Lys Thr Pro Lys Leu Glu Cys Cys Lys Tyr Gln Val Thr Phe Thr 
545                 550                 555                 560 


Asp Gln Lys Ala Leu Gln Glu His Ala Asp Tyr His Leu Ala Leu Lys 
                565                 570                 575     


Leu Ser Glu Gly Leu Asn Gly Ala Glu Glu Ser Ser Lys Asn Leu Ser 
            580                 585                 590         


Phe Gly Glu Lys Arg Leu Leu Phe Ser Arg Lys Arg Pro Asn Ser Gln 
        595                 600                 605             


His Thr Ala Thr Pro Gln Lys Lys Gln Val Thr Ser Ser Lys Asn Ile 
    610                 615                 620                 


Leu Ser Phe Phe Thr Arg Lys Lys 
625                 630         


<210>  54
<211>  928
<212>  PRT
<213>  Escherichia coli

<400>  54

Met Val Gln Ile Pro Gln Asn Pro Leu Ile Leu Val Asp Gly Ser Ser 
1               5                   10                  15      


Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro Leu Thr Asn Ser Ala 
            20                  25                  30          


Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu Asn Met Leu Arg Ser 
        35                  40                  45              


Leu Ile Met Gln Tyr Lys Pro Thr His Ala Ala Val Val Phe Asp Ala 
    50                  55                  60                  


Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu His Tyr Lys Ser His 
65                  70                  75                  80  


Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln Ile Glu Pro Leu His 
                85                  90                  95      


Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu Ala Val Ser Gly Val 
            100                 105                 110         


Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg Glu Ala Glu Lys Ala 
        115                 120                 125             


Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys Asp Met Ala Gln Leu 
    130                 135                 140                 


Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met Thr Asn Thr Ile Leu 
145                 150                 155                 160 


Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val Pro Pro Glu Leu Ile 
                165                 170                 175     


Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala Leu Leu Gln Gly Leu 
        195                 200                 205             


Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu Lys Ile Ala Gly Leu 
    210                 215                 220                 


Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys Leu Glu Gln Asn Lys 
225                 230                 235                 240 


Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr Ile Lys Thr Asp Val 
                245                 250                 255     


Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val Gln Gln Pro Ala Ala 
            260                 265                 270         


Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu Phe Lys Arg Trp Thr 
        275                 280                 285             


Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala Lys Gly Ala Lys Pro 
    290                 295                 300                 


Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp Glu Ala Pro Glu Val 
305                 310                 315                 320 


Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu 
                325                 330                 335     


Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe 
            340                 345                 350         


Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu 
        355                 360                 365             


Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro 
    370                 375                 380                 


Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys 
                405                 410                 415     


Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly 
            420                 425                 430         


Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile 
        435                 440                 445             


Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg 
    450                 455                 460                 


Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly 
465                 470                 475                 480 


Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg 
                485                 490                 495     


Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met 
            500                 505                 510         


Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn 
        515                 520                 525             


Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly 
    530                 535                 540                 


Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr 
545                 550                 555                 560 


Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu 
                565                 570                 575     


Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu 
            580                 585                 590         


Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser 
        595                 600                 605             


Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro 
    610                 615                 620                 


Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr 
625                 630                 635                 640 


Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His 
                645                 650                 655     


Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr 
            660                 665                 670         


Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg 
        675                 680                 685             


Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala 
    690                 695                 700                 


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp 
705                 710                 715                 720 


Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala 
                725                 730                 735     


Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu 
            740                 745                 750         


Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met 
        755                 760                 765             


Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala 
    770                 775                 780                 


Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Glu 
785                 790                 795                 800 


Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu 
                805                 810                 815     


Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn 
            820                 825                 830         


Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met 
        835                 840                 845             


Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp 
    850                 855                 860                 


Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val 
865                 870                 875                 880 


His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val 
                885                 890                 895     


Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val 
            900                 905                 910         


Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        915                 920                 925             


<210>  55
<211>  783
<212>  PRT
<213>  Escherichia coli

<400>  55

Met Ala Gln Ala Gly Phe Ile Leu Thr Arg His Trp Arg Asp Thr Pro 
1               5                   10                  15      


Gln Gly Thr Glu Val Ser Phe Trp Leu Ala Thr Asp Asn Gly Pro Leu 
            20                  25                  30          


Gln Val Thr Leu Ala Pro Gln Glu Ser Val Ala Phe Ile Pro Ala Asp 
        35                  40                  45              


Gln Val Pro Arg Ala Gln His Ile Leu Gln Gly Glu Gln Gly Phe Arg 
    50                  55                  60                  


Leu Thr Pro Leu Ala Leu Lys Asp Phe His Arg Gln Pro Val Tyr Gly 
65                  70                  75                  80  


Leu Tyr Cys Arg Ala His Arg Gln Leu Met Asn Tyr Glu Lys Arg Leu 
                85                  90                  95      


Arg Glu Gly Gly Val Thr Val Tyr Glu Ala Asp Val Arg Pro Pro Glu 
            100                 105                 110         


Arg Tyr Leu Met Glu Arg Phe Ile Thr Ser Pro Val Trp Val Glu Gly 
        115                 120                 125             


Asp Met His Asn Gly Thr Ile Val Asn Ala Arg Leu Lys Pro His Pro 
    130                 135                 140                 


Asp Tyr Arg Pro Pro Leu Lys Trp Val Ser Ile Asp Ile Glu Thr Thr 
145                 150                 155                 160 


Arg His Gly Glu Leu Tyr Cys Ile Gly Leu Glu Gly Cys Gly Gln Arg 
                165                 170                 175     


Ile Val Tyr Met Leu Gly Pro Glu Asn Gly Asp Ala Ser Ser Leu Asp 
            180                 185                 190         


Phe Glu Leu Glu Tyr Val Ala Ser Arg Pro Gln Leu Leu Glu Lys Leu 
        195                 200                 205             


Asn Ala Trp Phe Ala Asn Tyr Asp Pro Asp Val Ile Ile Gly Trp Asn 
    210                 215                 220                 


Val Val Gln Phe Asp Leu Arg Met Leu Gln Lys His Ala Glu Arg Tyr 
225                 230                 235                 240 


Arg Leu Pro Leu Arg Leu Gly Arg Asp Asn Ser Glu Leu Glu Trp Arg 
                245                 250                 255     


Glu His Gly Phe Lys Asn Gly Val Phe Phe Ala Gln Ala Lys Gly Arg 
            260                 265                 270         


Leu Ile Ile Asp Gly Ile Glu Ala Leu Lys Ser Ala Phe Trp Asn Phe 
        275                 280                 285             


Ser Ser Phe Ser Leu Glu Thr Val Ala Gln Glu Leu Leu Gly Glu Gly 
    290                 295                 300                 


Lys Ser Ile Asp Asn Pro Trp Asp Arg Met Asp Glu Ile Asp Arg Arg 
305                 310                 315                 320 


Phe Ala Glu Asp Lys Pro Ala Leu Ala Thr Tyr Asn Leu Lys Asp Cys 
                325                 330                 335     


Glu Leu Val Thr Gln Ile Phe His Lys Thr Glu Ile Met Pro Phe Leu 
            340                 345                 350         


Leu Glu Arg Ala Thr Val Asn Gly Leu Pro Val Asp Arg His Gly Gly 
        355                 360                 365             


Ser Val Ala Ala Phe Gly His Leu Tyr Phe Pro Arg Met His Arg Ala 
    370                 375                 380                 


Gly Tyr Val Ala Pro Asn Leu Gly Glu Val Pro Pro His Ala Ser Pro 
385                 390                 395                 400 


Gly Gly Tyr Val Met Asp Ser Arg Pro Gly Leu Tyr Asp Ser Val Leu 
                405                 410                 415     


Val Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Arg Thr Phe Leu 
            420                 425                 430         


Ile Asp Pro Val Gly Leu Val Glu Gly Met Ala Gln Pro Asp Pro Glu 
        435                 440                 445             


His Ser Thr Glu Gly Phe Leu Asp Ala Trp Phe Ser Arg Glu Lys His 
    450                 455                 460                 


Cys Leu Pro Glu Ile Val Thr Asn Ile Trp His Gly Arg Asp Glu Ala 
465                 470                 475                 480 


Lys Arg Gln Gly Asn Lys Pro Leu Ser Gln Ala Leu Lys Ile Ile Met 
                485                 490                 495     


Asn Ala Phe Tyr Gly Val Leu Gly Thr Thr Ala Cys Arg Phe Phe Asp 
            500                 505                 510         


Pro Arg Leu Ala Ser Ser Ile Thr Met Arg Gly His Gln Ile Met Arg 
        515                 520                 525             


Gln Thr Lys Ala Leu Ile Glu Ala Gln Gly Tyr Asp Val Ile Tyr Gly 
    530                 535                 540                 


Asp Thr Asp Ser Thr Phe Val Trp Leu Lys Gly Ala His Ser Glu Glu 
545                 550                 555                 560 


Glu Ala Ala Lys Ile Gly Arg Ala Leu Val Gln His Val Asn Ala Trp 
                565                 570                 575     


Trp Ala Glu Thr Leu Gln Lys Gln Arg Leu Thr Ser Ala Leu Glu Leu 
            580                 585                 590         


Glu Tyr Glu Thr His Phe Cys Arg Phe Leu Met Pro Thr Ile Arg Gly 
        595                 600                 605             


Ala Asp Thr Gly Ser Lys Lys Arg Tyr Ala Gly Leu Ile Gln Glu Gly 
    610                 615                 620                 


Asp Lys Gln Arg Met Val Phe Lys Gly Leu Glu Thr Val Arg Thr Asp 
625                 630                 635                 640 


Trp Thr Pro Leu Ala Gln Gln Phe Gln Gln Glu Leu Tyr Leu Arg Ile 
                645                 650                 655     


Phe Arg Asn Glu Pro Tyr Gln Glu Tyr Val Arg Glu Thr Ile Asp Lys 
            660                 665                 670         


Leu Met Ala Gly Glu Leu Asp Ala Arg Leu Val Tyr Arg Lys Arg Leu 
        675                 680                 685             


Arg Arg Pro Leu Ser Glu Tyr Gln Arg Asn Val Pro Pro His Val Arg 
    690                 695                 700                 


Ala Ala Arg Leu Ala Asp Glu Glu Asn Gln Lys Arg Gly Arg Pro Leu 
705                 710                 715                 720 


Gln Tyr Gln Asn Arg Gly Thr Ile Lys Tyr Val Trp Thr Thr Asn Gly 
                725                 730                 735     


Pro Glu Pro Leu Asp Tyr Gln Arg Ser Pro Leu Asp Tyr Glu His Tyr 
            740                 745                 750         


Leu Thr Arg Gln Leu Gln Pro Val Ala Glu Gly Ile Leu Pro Phe Ile 
        755                 760                 765             


Glu Asp Asn Phe Ala Thr Leu Met Thr Gly Gln Leu Gly Leu Phe 
    770                 775                 780             


<210>  56
<211>  1160
<212>  PRT
<213>  Escherichia coli

<400>  56

Met Ser Glu Pro Arg Phe Val His Leu Arg Val His Ser Asp Tyr Ser 
1               5                   10                  15      


Met Ile Asp Gly Leu Ala Lys Thr Ala Pro Leu Val Lys Lys Ala Ala 
            20                  25                  30          


Ala Leu Gly Met Pro Ala Leu Ala Ile Thr Asp Phe Thr Asn Leu Cys 
        35                  40                  45              


Gly Leu Val Lys Phe Tyr Gly Ala Gly His Gly Ala Gly Ile Lys Pro 
    50                  55                  60                  


Ile Val Gly Ala Asp Phe Asn Val Gln Cys Asp Leu Leu Gly Asp Glu 
65                  70                  75                  80  


Leu Thr His Leu Thr Val Leu Ala Ala Asn Asn Thr Gly Tyr Gln Asn 
                85                  90                  95      


Leu Thr Leu Leu Ile Ser Lys Ala Tyr Gln Arg Gly Tyr Gly Ala Ala 
            100                 105                 110         


Gly Pro Ile Ile Asp Arg Asp Trp Leu Ile Glu Leu Asn Glu Gly Leu 
        115                 120                 125             


Ile Leu Leu Ser Gly Gly Arg Met Gly Asp Val Gly Arg Ser Leu Leu 
    130                 135                 140                 


Arg Gly Asn Ser Ala Leu Val Asp Glu Cys Val Ala Phe Tyr Glu Glu 
145                 150                 155                 160 


His Phe Pro Asp Arg Tyr Phe Leu Glu Leu Ile Arg Thr Gly Arg Pro 
                165                 170                 175     


Asp Glu Glu Ser Tyr Leu His Ala Ala Val Glu Leu Ala Glu Ala Arg 
            180                 185                 190         


Gly Leu Pro Val Val Ala Thr Asn Asp Val Arg Phe Ile Asp Ser Ser 
        195                 200                 205             


Asp Phe Asp Ala His Glu Ile Arg Val Ala Ile His Asp Gly Phe Thr 
    210                 215                 220                 


Leu Asp Asp Pro Lys Arg Pro Arg Asn Tyr Ser Pro Gln Gln Tyr Met 
225                 230                 235                 240 


Arg Ser Glu Glu Glu Met Cys Glu Leu Phe Ala Asp Ile Pro Glu Ala 
                245                 250                 255     


Leu Ala Asn Thr Val Glu Ile Ala Lys Arg Cys Asn Val Thr Val Arg 
            260                 265                 270         


Leu Gly Glu Tyr Phe Leu Pro Gln Phe Pro Thr Gly Asp Met Ser Thr 
        275                 280                 285             


Glu Asp Tyr Leu Val Lys Arg Ala Lys Glu Gly Leu Glu Glu Arg Leu 
    290                 295                 300                 


Ala Phe Leu Phe Pro Asp Glu Glu Glu Arg Leu Lys Arg Arg Pro Glu 
305                 310                 315                 320 


Tyr Asp Glu Arg Leu Glu Thr Glu Leu Gln Val Ile Asn Gln Met Gly 
                325                 330                 335     


Phe Pro Gly Tyr Phe Leu Ile Val Met Glu Phe Ile Gln Trp Ser Lys 
            340                 345                 350         


Asp Asn Gly Val Pro Val Gly Pro Gly Arg Gly Ser Gly Ala Gly Ser 
        355                 360                 365             


Leu Val Ala Tyr Ala Leu Lys Ile Thr Asp Leu Asp Pro Leu Glu Phe 
    370                 375                 380                 


Asp Leu Leu Phe Glu Arg Phe Leu Asn Pro Glu Arg Val Ser Met Pro 
385                 390                 395                 400 


Asp Phe Asp Val Asp Phe Cys Met Glu Lys Arg Asp Gln Val Ile Glu 
                405                 410                 415     


His Val Ala Asp Met Tyr Gly Arg Asp Ala Val Ser Gln Ile Ile Thr 
            420                 425                 430         


Phe Gly Thr Met Ala Ala Lys Ala Val Ile Arg Asp Val Gly Arg Val 
        435                 440                 445             


Leu Gly His Pro Tyr Gly Phe Val Asp Arg Ile Ser Lys Leu Ile Pro 
    450                 455                 460                 


Pro Asp Pro Gly Met Thr Leu Ala Lys Ala Phe Glu Ala Glu Pro Gln 
465                 470                 475                 480 


Leu Pro Glu Ile Tyr Glu Ala Asp Glu Glu Val Lys Ala Leu Ile Asp 
                485                 490                 495     


Met Ala Arg Lys Leu Glu Gly Val Thr Arg Asn Ala Gly Lys His Ala 
            500                 505                 510         


Gly Gly Val Val Ile Ala Pro Thr Lys Ile Thr Asp Phe Ala Pro Leu 
        515                 520                 525             


Tyr Cys Asp Glu Glu Gly Lys His Pro Val Thr Gln Phe Asp Lys Ser 
    530                 535                 540                 


Asp Val Glu Tyr Ala Gly Leu Val Lys Phe Asp Phe Leu Gly Leu Arg 
545                 550                 555                 560 


Thr Leu Thr Ile Ile Asn Trp Ala Leu Glu Met Ile Asn Lys Arg Arg 
                565                 570                 575     


Ala Lys Asn Gly Glu Pro Pro Leu Asp Ile Ala Ala Ile Pro Leu Asp 
            580                 585                 590         


Asp Lys Lys Ser Phe Asp Met Leu Gln Arg Ser Glu Thr Thr Ala Val 
        595                 600                 605             


Phe Gln Leu Glu Ser Arg Gly Met Lys Asp Leu Ile Lys Arg Leu Gln 
    610                 615                 620                 


Pro Asp Cys Phe Glu Asp Met Ile Ala Leu Val Ala Leu Phe Arg Pro 
625                 630                 635                 640 


Gly Pro Leu Gln Ser Gly Met Val Asp Asn Phe Ile Asp Arg Lys His 
                645                 650                 655     


Gly Arg Glu Glu Ile Ser Tyr Pro Asp Val Gln Trp Gln His Glu Ser 
            660                 665                 670         


Leu Lys Pro Val Leu Glu Pro Thr Tyr Gly Ile Ile Leu Tyr Gln Glu 
        675                 680                 685             


Gln Val Met Gln Ile Ala Gln Val Leu Ser Gly Tyr Thr Leu Gly Gly 
    690                 695                 700                 


Ala Asp Met Leu Arg Arg Ala Met Gly Lys Lys Lys Pro Glu Glu Met 
705                 710                 715                 720 


Ala Lys Gln Arg Ser Val Phe Ala Glu Gly Ala Glu Lys Asn Gly Ile 
                725                 730                 735     


Asn Ala Glu Leu Ala Met Lys Ile Phe Asp Leu Val Glu Lys Phe Ala 
            740                 745                 750         


Gly Tyr Gly Phe Asn Lys Ser His Ser Ala Ala Tyr Ala Leu Val Ser 
        755                 760                 765             


Tyr Gln Thr Leu Trp Leu Lys Ala His Tyr Pro Ala Glu Phe Met Ala 
    770                 775                 780                 


Ala Val Met Thr Ala Asp Met Asp Asn Thr Glu Lys Val Val Gly Leu 
785                 790                 795                 800 


Val Asp Glu Cys Trp Arg Met Gly Leu Lys Ile Leu Pro Pro Asp Ile 
                805                 810                 815     


Asn Ser Gly Leu Tyr His Phe His Val Asn Asp Asp Gly Glu Ile Val 
            820                 825                 830         


Tyr Gly Ile Gly Ala Ile Lys Gly Val Gly Glu Gly Pro Ile Glu Ala 
        835                 840                 845             


Ile Ile Glu Ala Arg Asn Lys Gly Gly Tyr Phe Arg Glu Leu Phe Asp 
    850                 855                 860                 


Leu Cys Ala Arg Thr Asp Thr Lys Lys Leu Asn Arg Arg Val Leu Glu 
865                 870                 875                 880 


Lys Leu Ile Met Ser Gly Ala Phe Asp Arg Leu Gly Pro His Arg Ala 
                885                 890                 895     


Ala Leu Met Asn Ser Leu Gly Asp Ala Leu Lys Ala Ala Asp Gln His 
            900                 905                 910         


Ala Lys Ala Glu Ala Ile Gly Gln Ala Asp Met Phe Gly Val Leu Ala 
        915                 920                 925             


Glu Glu Pro Glu Gln Ile Glu Gln Ser Tyr Ala Ser Cys Gln Pro Trp 
    930                 935                 940                 


Pro Glu Gln Val Val Leu Asp Gly Glu Arg Glu Thr Leu Gly Leu Tyr 
945                 950                 955                 960 


Leu Thr Gly His Pro Ile Asn Gln Tyr Leu Lys Glu Ile Glu Arg Tyr 
                965                 970                 975     


Val Gly Gly Val Arg Leu Lys Asp Met His Pro Thr Glu Arg Gly Lys 
            980                 985                 990         


Val Ile Thr Ala Ala Gly Leu Val  Val Ala Ala Arg Val  Met Val Thr 
        995                 1000                 1005             


Lys Arg  Gly Asn Arg Ile Gly  Ile Cys Thr Leu Asp  Asp Arg Ser 
    1010                 1015                 1020             


Gly Arg  Leu Glu Val Met Leu  Phe Thr Asp Ala Leu  Asp Lys Tyr 
    1025                 1030                 1035             


Gln Gln  Leu Leu Glu Lys Asp  Arg Ile Leu Ile Val  Ser Gly Gln 
    1040                 1045                 1050             


Val Ser  Phe Asp Asp Phe Ser  Gly Gly Leu Lys Met  Thr Ala Arg 
    1055                 1060                 1065             


Glu Val  Met Asp Ile Asp Glu  Ala Arg Glu Lys Tyr  Ala Arg Gly 
    1070                 1075                 1080             


Leu Ala  Ile Ser Leu Thr Asp  Arg Gln Ile Asp Asp  Gln Leu Leu 
    1085                 1090                 1095             


Asn Arg  Leu Arg Gln Ser Leu  Glu Pro His Arg Ser  Gly Thr Ile 
    1100                 1105                 1110             


Pro Val  His Leu Tyr Tyr Gln  Arg Ala Asp Ala Arg  Ala Arg Leu 
    1115                 1120                 1125             


Arg Phe  Gly Ala Thr Trp Arg  Val Ser Pro Ser Asp  Arg Leu Leu 
    1130                 1135                 1140             


Asn Asp  Leu Arg Gly Leu Ile  Gly Ser Glu Gln Val  Glu Leu Glu 
    1145                 1150                 1155             


Phe Asp  
    1160 


<210>  57
<211>  775
<212>  PRT
<213>  Thermococcus guaymasensis

<400>  57

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Arg Thr Ile Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Arg Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Glu Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Met Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Ile Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Arg Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asn Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Arg Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Ile Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Arg Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Arg Lys 
    770                 775 


<210>  58
<211>  775
<212>  PRT
<213>  Pyrococcus furiosus

<400>  58

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  59
<211>  4101
<212>  DNA
<213>  Artificial

<220>
<223>  Cas9

<400>  59
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  60
<211>  4101
<212>  DNA
<213>  Artificial

<220>
<223>  nCas9

<400>  60
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctggc cgacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctgccctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaaggcccct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  61
<211>  4101
<212>  DNA
<213>  Artificial

<220>
<223>  nCas9(D10A)

<400>  61
gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  62
<211>  4101
<212>  DNA
<213>  Artificial

<220>
<223>  nCas9(H840A)

<400>  62
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgccatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  63
<211>  1761
<212>  DNA
<213>  Escherichia coli

<400>  63
atgacaaaaa catctaaact tgacgcactt agggctgcta cttcacgtga agacttggct       60

aaaattttag atattaagtt ggtattttta actaacgttc tatatagaat cggctcggat      120

aatcaataca ctcaatttac aataccgaag aaaggaaaag gggtaaggac tatttctgca      180

cctacagacc ggttgaagga catccaacga agaatatgtg acttactttc tgattgtaga      240

gatgagatct ttgctataag gaaaattagt aacaactatt cctttggttt tgagagggga      300

aaatcaataa tcctaaatgc ttataagcat agaggcaaac aaataatatt aaatatagat      360

cttaaggatt tttttgaaag ctttaatttt ggacgagtta gaggatattt tctttccaat      420

caggattttt tattaaatcc tgtggtggca acgacacttg caaaagctgc atgctataat      480

ggaaccctcc cccaaggaag tccatgttct cctattatct caaatctaat ttgcaatatt      540

atggatatga gattagctaa gctggctaaa aaatatggat gtacttatag cagatatgct      600

gatgatataa caatttctac aaataaaaat acatttccgt tagaaatggc tactgtgcaa      660

cctgaagggg ttgttttggg aaaagttttg gtaaaagaaa tagaaaactc tggattcgaa      720

ataaatgatt caaagactag gcttacgtat aagacatcaa ggcaagaagt aacgggactt      780

acagttaaca gaatcgttaa tattgataga tgttattata aaaaaactcg ggcgttggca      840

catgctttgt atcgtacagg tgaatataaa gtgccagatg aaaatggtgt tttagtttca      900

ggaggtctgg ataaacttga ggggatgttt ggttttattg atcaagttga taagtttaac      960

aatataaaga aaaaactgaa caagcaacct gatagatatg tattgactaa tgcgactttg     1020

catggtttta aattaaagtt gaatgcgcga gaaaaagcat atagtaaatt tatttactat     1080

aaattttttc atggcaacac ctgtcctacg ataattacag aagggaagac tgatcggata     1140

tatttgaagg ctgctttgca ttctttggag acatcatatc ctgagttgtt tagagaaaaa     1200

acagatagta aaaagaaaga aataaatctt aatatattta aatctaatga aaagaccaaa     1260

tattttttag atctttctgg gggaactgca gatctgaaaa aatttgtaga gcgttataaa     1320

aataattatg cttcttatta tggttctgtt ccaaaacagc cagtgattat ggttcttgat     1380

aatgatacag gtccaagcga tttacttaat tttctgcgca ataaagttaa aagctgccca     1440

gacgatgtaa ctgaaatgag aaagatgaaa tatattcatg ttttctataa tttatatata     1500

gttctcacac cattgagtcc ttccggcgaa caaacttcaa tggaggatct tttccctaaa     1560

gatattttag atatcaagat tgatggtaag aaattcaaca aaaataatga tggagactca     1620

aaaacggaat atgggaagca tattttttcc atgagggttg ttagagataa aaagcggaaa     1680

atagatttta aggcattttg ttgtattttt gatgctataa aagatataaa ggaacattat     1740

aaattaatgt taaatagcta a                                               1761


<210>  64
<211>  132
<212>  DNA
<213>  Escherichia coli

<400>  64
cacgcatgta ggcagatttg ttggttgtga atcgcaacca gtggccttaa tggcaggagg       60

aatcgcctcc ctaaaatcct tgattcagag ctatacggca ggtgtgctgt gcgaaggagt      120

gcctgcatgc gt                                                          132


<210>  65
<211>  99
<212>  DNA
<213>  Escherichia coli

<400>  65
atgaaatcgc atgatcgatt gaggatcgtc tttgctcaga tccgccagaa ctggcggctt       60

ttgctcatgt tatgcatgtg catgaaaacc actgcataa                              99


<210>  66
<211>  170
<212>  DNA
<213>  Escherichia coli

<400>  66
atgcgcaccc ttagcgagag gtttatcatt aaggtcaacc tctggatgtt gtttcggcat       60

cctgcattga atctgagtta ctgtctgttt tccttgttgg aacggagagc atcgcctgat      120

gctctccgag ccaaccagga aacccgtttt ttctgacgta agggtgcgca                 170


<210>  67
<211>  960
<212>  DNA
<213>  Escherichia coli

<400>  67
atggatgcta cccggacaac ccttctggcg ctcgatttgt tcggctcgcc gggctggagc       60

gccgataaag aaatacagcg actgcatgcg ctcagtaatc atgccggacg ccattaccga      120

cgcattattc tttctaaacg ccacggtggt cagcggctgg tgttagcccc tgattacttg      180

ctcaaaaccg tacagcgcaa cattcttaag aacgtccttt cacaatttcc gctttcccct      240

tttgctacag cctaccgacc aggttgccca atcgtcagca acgcgcagcc acactgccaa      300

cagccgcaga tcctgaaact cgatatcgaa aactttttcg atagcattag ctggttacag      360

gtctggcgtg tgtttcgcca ggcccagttg ccacgtaatg tggtaaccat gctgacctgg      420

atttgttgtt ataacgacgc gttaccgcag ggggcaccaa cttcgccagc catttccaat      480

cttgtgatgc gccgttttga tgaacgcata ggggaatggt gtcaggctcg gggaattacc      540

tacacccgct actgcgatga catgaccttt tcaggtcact tcaatgcccg ccaggttaaa      600

aataaagtgt gcggattgtt agcggagctg ggcctgagcc tcaataaacg caaaggctgc      660

ctgatagctg cctgtaagcg ccagcaagta accgggattg ttgttaatca caagccacag      720

cttgcccgtg aagcgcgccg ggcgctgcgt caggaggtgc atttgtgcca aaaatatggc      780

gttatttcgc atcttagtca tcgtggtgaa cttgatcctt ctggcgatct ccacgcacag      840

gcaacggcgt atctttatgc tttgcaggga agaataaact ggttattgca aatcaaccct      900

gaggatgagg cctttcaaca ggcgagagag agtgtaaagc gaatgctggt tgcatggtaa      960


<210>  68
<211>  176
<212>  DNA
<213>  Escherichia coli

<400>  68
cgccagcagt ggcaatagcg tttccggcct tttgtgccgg gagggtcggc gagtcgctga       60

cttaacgcca gtagtatgtc catataccca aagtcgcttc attgtacctg agtacgcttc      120

gcgtacgtcg cgctgacgcg ctcagtacag ttacgcgcct tcgggatggt ttaatg          176


<210>  69
<211>  1458
<212>  DNA
<213>  Myxococcus xanthus

<400>  69
atgaccgcca ggctggaccc gttcgtcccc gcagcttcgc cgcaggccgt gcccacgccc       60

gagctcaccg ctccgtcgtc agacgcggcc gcgaagcgtg aagcccgccg gctcgcgcac      120

gaagcgttgc tcgtccgcgc gaaggccatc gacgaagcgg gcggcgccga cgactgggtg      180

caggcgcagc tcgtctccaa gggcctcgcg gtggaggacc tggacttctc cagcgcctcc      240

gagaaggaca agaaggcctg gaaggagaag aagaaggccg aggccaccga gcgccgcgcg      300

ctgaagcgtc aggcgcacga ggcgtggaag gccacgcacg tgggccacct gggcgcgggc      360

gtgcactggg cggaggaccg cctggccgac gcgttcgacg tgccccaccg cgaggagcgc      420

gcccgggcca acggcctgac ggagctggac tcggcggagg cgctggccaa ggcgctgggg      480

ctgagcgtgt ccaagctgcg ctggttcgcg ttccaccgcg aggtggacac ggccacgcac      540

tacgtgagct ggacgattcc gaagcgggac ggcagcaagc gcacgattac gtcccccaag      600

cctgagctga aggcagcgca gcgctgggtg ctgtccaacg tcgtggagcg gctgccggtg      660

cacggcgcgg cgcacggctt cgtggcggga cgctccatcc tcaccaacgc gctggcccac      720

cagggcgcgg acgtggtggt gaaggtggac ctcaaggact tcttcccctc cgtcacctgg      780

cgccgggtga agggcctgtt gcgcaagggc ggcctgcggg agggcacgtc cacgctgctg      840

tcgctgctct ccacggaagc gccgcgggag gcggtgcagt tccggggcaa gctgctgcac      900

gtggccaagg gcccgcgcgc gctgccccag ggcgcgccca cgtcgccggg catcaccaac      960

gcgctgtgcc tgaagctgga caagcggctg tccgcgctcg cgaagcggct gggcttcacg     1020

tacacgcgct acgcggacga cctgaccttc tcgtggacga aggcgaagca gcccaagccg     1080

cggcggacgc agcgtccccc ggtggcggtg ctgctgtctc gcgtgcagga agtggtggag     1140

gcggagggct tccgcgtgca cccggacaag acgcgcgtgg cgcgcaaggg cacgcggcag     1200

cgggtgacgg ggctggtcgt gaatgcggcg ggcaaggacg cgccggcggc ccgagtcccg     1260

cgcgacgtgg tgcgccagct ccgcgccgcc atccacaacc ggaagaaggg caagccgggc     1320

cgcgagggcg agtcgctgga gcagctcaag ggcatggccg ccttcatcca catgacggac     1380

ccggccaagg gccgcgcctt cctggctcag ctcacggagc tggagtccac ggcgagcgcg     1440

gctccgcagg cggagtga                                                   1458


<210>  70
<211>  231
<212>  DNA
<213>  Myxococcus xanthus

<400>  70
agaggtccgg agtgcatcag cctgagcgcc tcgagcggcg gagcggcgtt gcgccgctcc       60

ggttggaatg caggacactc tccgcaaggt agcctgttct tggctctctc cctcctaggc      120

actacggcca gggtgggtag cggagccaac gacgcgaccg ccgtttaccc accccggccg      180

tagtgcctag gaggggagag ccggtgaggc taccgtgccc caggtaagat g               231


<210>  71
<211>  334
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric guide nucleic acid sequences (guide DNA)

<400>  71
cacgcatgta ggcagatttg ttggttgtga atcgcaacca gtggccttaa tggcaggagg       60

aatcgcctcc agagtcgccg tctccaaggt gaaagcggaa gtagggcctt cgcgcacctc      120

atggaatccc ttctgcagca cctagatcgc ttttctgaac tcctagcagt atctagcact      180

acctacgtca gcacctggga ccccgcggtg tgctgtgcga aggagtgcct gcatgcgtgg      240

aatcccttct gcagcaccgt tttagagcta gaaatagcaa gttaaaataa ggctagtccg      300

ttatcaactt gaaaaagtgg caccgagtcg gtgc                                  334


<210>  72
<211>  361
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric guide nucleic acid sequences (guide DNA)

<400>  72
atgcgcaccc ttagcgagag gtttatcatt aaggtcaacc tctggatgtt gtttcggcat       60

cctgcattga atctgagtta ctgtctgttt tcctagagtc gccgtctcca aggtgaaagc      120

ggaagtaggg ccttcgcgca cctcatggaa tcccttctgc agcacctaga tcgcttttct      180

gaactcctag cagtatctag cactacctac gtcagcacct gggaccccgc caggaaaccc      240

gttttttctg acgtaagggt gcgcaggaat cccttctgca gcaccgtttt agagctagaa      300

atagcaagtt aaaataaggc tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg      360

c                                                                      361


<210>  73
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric guide nucleic acid sequences (guide DNA)

<400>  73
gccagcagtg gcaatagcgt ttccggcctt ttgtgccggg agggtcggcg agtcgctgac       60

ttaacgccag tagtatgtcc atatacccaa gagtcgccgt ctccaaggtg aaagcggaag      120

tagggccttc gcgcacctca tggaatccct tctgcagcac ctagatcgct tttctgaact      180

cctagcagta tctagcacta cctacgtcag cacctgggac cccgcgggat ggtttaatgg      240

tattgccgcg gaatcccttc tgcagcaccg ttttagagct agaaatagca agttaaaata      300

aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgc                      345


<210>  74
<211>  364
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric guide nucleic acid sequences (guide DNA)

<400>  74
agaggtccgg agtgcatcag cctgagcgcc tcgagcggcg gagcggcgtt gcgccgctcc       60

ggttggaatg caggacactc tccgcaaggt agagtcgccg tctccaaggt gaaagcggaa      120

gtagggcctt cgcgcacctc atggaatccc ttctgcagca cctagatcgc ttttctgaac      180

tcctagcagt atctagcact acctacgtca gcacctggga ccccgctgag gctaccgtgc      240

cccaggtaag atggtggtgc tttcccgggg aatcccttct gcagcaccgt tttagagcta      300

gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg      360

gtgc                                                                   364


<210>  75
<211>  1244
<212>  PRT
<213>  Artificial

<220>
<223>  Cas12a RNP protein sequence

<400>  75

Met Gly Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Pro  Lys Lys Lys 
    1220                 1225                 1230             


Arg Lys  Val Leu Glu His His  His His His His 
    1235                 1240                 


<210>  76
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  PWsp137 Target Sequence

<400>  76
ccucacuccu gcucggugaa uuu                                               23


<210>  77
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  PWsp137 crRNA

<400>  77
aauuucuacu aaguguagau ccucacuccu gcucggugaa uuu                         43


<210>  78
<211>  103
<212>  DNA
<213>  Artificial

<220>
<223>  PWsp137 crRNA - PBS 24bp; RTT 36bp

<400>  78
aauuucuacu aaguguagau ccucacuccu gcucggugaa uuuctggggc cgtaaccctc       60

actcctgctc ggtgaatttg gctcagcagg cacctgcctc agc                        103


<210>  79
<211>  115
<212>  DNA
<213>  Artificial

<220>
<223>  PWsp137 crRNA - PBS 36bp; RTT 36bp

<400>  79
aauuucuacu aaguguagau ccucacuccu gcucggugaa uuuctggggc cgtaaccctc       60

actcctgctc ggtgaatttg gctcagcagg cacctgcctc agctgctcac ttgag           115


<210>  80
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  PWsp453 Target Sequence

<400>  80
uaugaguuac aacgaacacc uca                                               23


<210>  81
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  PWsp453 crRNA

<400>  81
aauuucuacu aaguguagau uaugaguuac aacgaacacc uca                         43


<210>  82
<211>  103
<212>  DNA
<213>  Artificial

<220>
<223>  PWsp453 crRNA - PBS 24bp; RTT 36bp

<400>  82
aauuucuacu aaguguagau uaugaguuac aacgaacacc ucaggaactc agtaaatatg       60

agttacaacg aacacctcag gtaatgacta agatgactgc caa                        103


<210>  83
<211>  115
<212>  DNA
<213>  Artificial

<220>
<223>  PWsp453 crRNA - PBS 36bp; RTT 36bp

<400>  83
aauuucuacu aaguguagau uaugaguuac aacgaacacc ucaggaactc agtaaatatg       60

agttacaacg aacacctcag gtaatgacta agatgactgc caaggggcat atgag           115


<210>  84
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  PWsp454 Target Sequence

<400>  84
cacgucucau augccccuug gca                                               23


<210>  85
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  PWsp454 crRNA

<400>  85
aauuucuacu aaguguagau cacgucucau augccccuug gca                         43


<210>  86
<211>  103
<212>  DNA
<213>  Artificial

<220>
<223>  PWsp454 crRNA - PBS 24bp; RTT 36bp

<400>  86
aauuucuacu aaguguagau cacgucucau augccccuug gcagtatccc agtaaacacg       60

tctcatatgc cccttggcag tcatcttagt cattacctga ggt                        103


<210>  87
<211>  115
<212>  DNA
<213>  Artificial

<220>
<223>  PWsp454 crRNA - PBS 36bp; RTT 36bp

<400>  87
aauuucuacu aaguguagau cacgucucau augccccuug gcagtatccc agtaaacacg       60

tctcatatgc cccttggcag tcatcttagt cattacctga ggtgttcgtt gtaac           115


<210>  88
<211>  579
<212>  PRT
<213>  Artificial

<220>
<223>  Klentaq aa

<400>  88

Met Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Ser Gly Gly Leu Leu His Glu Phe 
            20                  25                  30          


Gly Leu Leu Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro 
        35                  40                  45              


Pro Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met 
    50                  55                  60                  


Trp Ala Asp Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His 
65                  70                  75                  80  


Arg Ala Pro Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg 
                85                  90                  95      


Gly Leu Leu Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu 
            100                 105                 110         


Gly Leu Pro Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp 
        115                 120                 125             


Pro Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu 
    130                 135                 140                 


Trp Thr Glu Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe 
145                 150                 155                 160 


Ala Asn Leu Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu 
                165                 170                 175     


Tyr Arg Glu Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu 
            180                 185                 190         


Ala Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu 
        195                 200                 205             


Glu Val Ala Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu 
    210                 215                 220                 


Ala Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val 
225                 230                 235                 240 


Leu Phe Asp Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr 
                245                 250                 255     


Gly Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala 
            260                 265                 270         


His Pro Ile Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu 
        275                 280                 285             


Lys Ser Thr Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr 
    290                 295                 300                 


Gly Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg 
305                 310                 315                 320 


Leu Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro 
                325                 330                 335     


Leu Gly Gln Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu 
            340                 345                 350         


Leu Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His 
        355                 360                 365             


Leu Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp 
    370                 375                 380                 


Ile His Thr Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala 
385                 390                 395                 400 


Val Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val 
                405                 410                 415     


Leu Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro 
            420                 425                 430         


Tyr Glu Glu Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro 
        435                 440                 445             


Lys Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg 
    450                 455                 460                 


Gly Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu 
465                 470                 475                 480 


Glu Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe 
                485                 490                 495     


Asn Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met 
            500                 505                 510         


Val Lys Leu Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu 
        515                 520                 525             


Gln Val His Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu 
    530                 535                 540                 


Ala Val Ala Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu 
545                 550                 555                 560 


Ala Val Pro Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser 
                565                 570                 575     


Ala Lys Glu 
            


<210>  89
<211>  800
<212>  PRT
<213>  Artificial

<220>
<223>  Therminator aa

<400>  89

Met Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Ser Gly Ile Leu Asp Thr Asp Tyr 
            20                  25                  30          


Ile Thr Glu Asn Gly Lys Pro Val Ile Arg Val Phe Lys Lys Glu Asn 
        35                  40                  45              


Gly Glu Phe Lys Ile Glu Tyr Asp Arg Thr Phe Glu Pro Tyr Phe Tyr 
    50                  55                  60                  


Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Asp Val Lys Lys Val Thr 
65                  70                  75                  80  


Ala Lys Arg His Gly Thr Val Val Lys Val Lys Arg Ala Glu Lys Val 
                85                  90                  95      


Gln Lys Lys Phe Leu Gly Arg Pro Ile Glu Val Trp Lys Leu Tyr Phe 
            100                 105                 110         


Asn His Pro Gln Asp Val Pro Ala Ile Arg Asp Arg Ile Arg Ala His 
        115                 120                 125             


Pro Ala Val Val Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala Lys Arg 
    130                 135                 140                 


Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu Glu Leu 
145                 150                 155                 160 


Thr Met Leu Ala Phe Ala Ile Ala Thr Leu Tyr His Glu Gly Glu Glu 
                165                 170                 175     


Phe Gly Thr Gly Pro Ile Leu Met Ile Ser Tyr Ala Asp Gly Ser Glu 
            180                 185                 190         


Ala Arg Val Ile Thr Trp Lys Lys Ile Asp Leu Pro Tyr Val Asp Val 
        195                 200                 205             


Val Ser Thr Glu Lys Glu Met Ile Lys Arg Phe Leu Arg Val Val Arg 
    210                 215                 220                 


Glu Lys Asp Pro Asp Val Leu Ile Thr Tyr Asn Gly Asp Asn Phe Asp 
225                 230                 235                 240 


Phe Ala Tyr Leu Lys Lys Arg Cys Glu Glu Leu Gly Ile Lys Phe Thr 
                245                 250                 255     


Leu Gly Arg Asp Gly Ser Glu Pro Lys Ile Gln Arg Met Gly Asp Arg 
            260                 265                 270         


Phe Ala Val Glu Val Lys Gly Arg Ile His Phe Asp Leu Tyr Pro Val 
        275                 280                 285             


Ile Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr 
    290                 295                 300                 


Glu Ala Val Phe Gly Lys Pro Lys Glu Lys Val Tyr Ala Glu Glu Ile 
305                 310                 315                 320 


Ala Gln Ala Trp Glu Ser Gly Glu Gly Leu Glu Arg Val Ala Arg Tyr 
                325                 330                 335     


Ser Met Glu Asp Ala Lys Val Thr Tyr Glu Leu Gly Arg Glu Phe Phe 
            340                 345                 350         


Pro Met Glu Ala Gln Leu Ser Arg Leu Ile Gly Gln Ser Leu Trp Asp 
        355                 360                 365             


Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp Phe Leu Leu Arg 
    370                 375                 380                 


Lys Ala Tyr Lys Arg Asn Glu Leu Ala Pro Asn Lys Pro Asp Glu Arg 
385                 390                 395                 400 


Glu Leu Ala Arg Arg Arg Gly Gly Tyr Ala Gly Gly Tyr Val Lys Glu 
                405                 410                 415     


Pro Glu Arg Gly Leu Trp Asp Asn Ile Val Tyr Leu Asp Phe Arg Ser 
            420                 425                 430         


Leu Tyr Pro Ser Ile Ile Ile Thr His Asn Val Ser Pro Asp Thr Leu 
        435                 440                 445             


Asn Arg Glu Gly Cys Lys Glu Tyr Asp Val Ala Pro Glu Val Gly His 
    450                 455                 460                 


Lys Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro Ser Leu Leu Gly Asp 
465                 470                 475                 480 


Leu Leu Glu Glu Arg Gln Lys Ile Lys Arg Lys Met Lys Ala Thr Val 
                485                 490                 495     


Asp Pro Leu Glu Lys Lys Leu Leu Asp Tyr Arg Gln Arg Leu Ile Lys 
            500                 505                 510         


Ile Leu Ala Asn Ser Phe Tyr Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg 
        515                 520                 525             


Trp Tyr Cys Lys Glu Cys Ala Glu Ser Val Thr Ala Trp Gly Arg Glu 
    530                 535                 540                 


Tyr Ile Glu Met Val Ile Arg Glu Leu Glu Glu Lys Phe Gly Phe Lys 
545                 550                 555                 560 


Val Leu Tyr Ala Asp Thr Asp Gly Leu His Ala Thr Ile Pro Gly Ala 
                565                 570                 575     


Asp Ala Glu Thr Val Lys Lys Lys Ala Lys Glu Phe Leu Lys Tyr Ile 
            580                 585                 590         


Asn Pro Lys Leu Pro Gly Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr 
        595                 600                 605             


Val Arg Gly Phe Phe Val Thr Lys Lys Lys Tyr Ala Val Ile Asp Glu 
    610                 615                 620                 


Glu Gly Lys Ile Thr Thr Arg Gly Leu Glu Ile Val Arg Arg Asp Trp 
625                 630                 635                 640 


Ser Glu Ile Ala Lys Glu Thr Gln Ala Arg Val Leu Glu Ala Ile Leu 
                645                 650                 655     


Lys His Gly Asp Val Glu Glu Ala Val Arg Ile Val Lys Glu Val Thr 
            660                 665                 670         


Glu Lys Leu Ser Lys Tyr Glu Val Pro Pro Glu Lys Leu Val Ile His 
        675                 680                 685             


Glu Gln Ile Thr Arg Asp Leu Arg Asp Tyr Lys Ala Thr Gly Pro His 
    690                 695                 700                 


Val Ala Val Ala Lys Arg Leu Ala Ala Arg Gly Val Lys Ile Arg Pro 
705                 710                 715                 720 


Gly Thr Val Ile Ser Tyr Ile Val Leu Lys Gly Ser Gly Arg Ile Gly 
                725                 730                 735     


Asp Arg Ala Ile Pro Ala Asp Glu Phe Asp Pro Thr Lys His Arg Tyr 
            740                 745                 750         


Asp Ala Glu Tyr Tyr Ile Glu Asn Gln Val Leu Pro Ala Val Glu Arg 
        755                 760                 765             


Ile Leu Lys Ala Phe Gly Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys 
    770                 775                 780                 


Thr Lys Gln Val Gly Leu Gly Ala Trp Leu Lys Val Lys Gly Lys Lys 
785                 790                 795                 800 


<210>  90
<211>  876
<212>  PRT
<213>  Artificial

<220>
<223>  Pfu-Ssod7 aa

<400>  90

Met Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Ser Gly His Ile Glu Gly Arg His 
            20                  25                  30          


Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
        35                  40                  45              


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
    50                  55                  60                  


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
65                  70                  75                  80  


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
                85                  90                  95      


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
            100                 105                 110         


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
        115                 120                 125             


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
    130                 135                 140                 


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
145                 150                 155                 160 


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
                165                 170                 175     


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
            180                 185                 190         


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
        195                 200                 205             


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
    210                 215                 220                 


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
225                 230                 235                 240 


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
                245                 250                 255     


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
            260                 265                 270         


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
        275                 280                 285             


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
    290                 295                 300                 


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
305                 310                 315                 320 


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
                325                 330                 335     


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
            340                 345                 350         


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
        355                 360                 365             


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
    370                 375                 380                 


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
385                 390                 395                 400 


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
                405                 410                 415     


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
            420                 425                 430         


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
        435                 440                 445             


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
    450                 455                 460                 


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
465                 470                 475                 480 


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
                485                 490                 495     


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
            500                 505                 510         


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
        515                 520                 525             


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
    530                 535                 540                 


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
545                 550                 555                 560 


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
                565                 570                 575     


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
            580                 585                 590         


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
        595                 600                 605             


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
    610                 615                 620                 


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
625                 630                 635                 640 


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
                645                 650                 655     


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
            660                 665                 670         


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
        675                 680                 685             


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
    690                 695                 700                 


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
705                 710                 715                 720 


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
                725                 730                 735     


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
            740                 745                 750         


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
        755                 760                 765             


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
    770                 775                 780                 


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
785                 790                 795                 800 


Trp Leu Asn Ile Lys Lys Ser Gly Thr Gly Gly Gly Gly Ala Thr Val 
                805                 810                 815     


Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Ile Ser Lys Ile 
            820                 825                 830         


Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe Thr Tyr Asp Glu 
        835                 840                 845             


Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys Asp Ala Pro 
    850                 855                 860                 


Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
865                 870                 875     


<210>  91
<211>  648
<212>  PRT
<213>  Artificial

<220>
<223>  Klenow aa

<400>  91

Met Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile 
            20                  25                  30          


Leu Asp Glu Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala 
        35                  40                  45              


Pro Val Phe Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser 
    50                  55                  60                  


Ala Asn Leu Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala 
65                  70                  75                  80  


Tyr Ile Pro Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser 
                85                  90                  95      


Arg Glu Arg Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys 
            100                 105                 110         


Ala Leu Lys Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala 
        115                 120                 125             


Asn Tyr Gly Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu 
    130                 135                 140                 


Ser Tyr Ile Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu 
145                 150                 155                 160 


Ala Glu Arg Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala 
                165                 170                 175     


Gly Lys Gly Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu 
            180                 185                 190         


Ala Gly Arg Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His 
        195                 200                 205             


Leu Lys Met Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val 
    210                 215                 220                 


Phe Glu Asn Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu 
225                 230                 235                 240 


Arg Asn Gly Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu 
                245                 250                 255     


Glu Leu Thr Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile 
            260                 265                 270         


Ala Gly Glu Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile 
        275                 280                 285             


Leu Phe Glu Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly 
    290                 295                 300                 


Ala Pro Ser Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr 
305                 310                 315                 320 


Pro Leu Pro Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys 
                325                 330                 335     


Ser Thr Tyr Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly 
            340                 345                 350         


Arg Val His Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu 
        355                 360                 365             


Ser Ser Thr Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu 
    370                 375                 380                 


Gly Arg Arg Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile 
385                 390                 395                 400 


Val Ser Ala Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu 
                405                 410                 415     


Ser Arg Asp Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile 
            420                 425                 430         


His Arg Ala Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val 
        435                 440                 445             


Thr Ser Glu Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile 
    450                 455                 460                 


Tyr Gly Met Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg 
465                 470                 475                 480 


Lys Glu Ala Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly 
                485                 490                 495     


Val Leu Glu Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly 
            500                 505                 510         


Tyr Val Glu Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys 
        515                 520                 525             


Ser Ser Asn Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn 
    530                 535                 540                 


Ala Pro Met Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile 
545                 550                 555                 560 


Ala Val Asp Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile 
                565                 570                 575     


Met Gln Val His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val 
            580                 585                 590         


Asp Ala Val Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg 
        595                 600                 605             


Leu Asp Val Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp 
    610                 615                 620                 


Gln Ala His Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe 
625                 630                 635                 640 


Glu Pro Lys Lys Lys Arg Lys Val 
                645             


<210>  92
<211>  970
<212>  PRT
<213>  Escherichia coli

<400>  92

Met Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Val Gln Ile Pro Gln Asn Pro Leu Ile Leu 
            20                  25                  30          


Val Asp Gly Ser Ser Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro 
        35                  40                  45              


Leu Thr Asn Ser Ala Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu 
    50                  55                  60                  


Asn Met Leu Arg Ser Leu Ile Met Gln Tyr Lys Pro Thr His Ala Ala 
65                  70                  75                  80  


Val Val Phe Asp Ala Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu 
                85                  90                  95      


His Tyr Lys Ser His Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln 
            100                 105                 110         


Ile Glu Pro Leu His Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu 
        115                 120                 125             


Ala Val Ser Gly Val Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg 
    130                 135                 140                 


Glu Ala Glu Lys Ala Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys 
145                 150                 155                 160 


Asp Met Ala Gln Leu Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met 
                165                 170                 175     


Thr Asn Thr Ile Leu Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val 
            180                 185                 190         


Pro Pro Glu Leu Ile Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser 
        195                 200                 205             


Asp Asn Ile Pro Gly Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala 
    210                 215                 220                 


Leu Leu Gln Gly Leu Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu 
225                 230                 235                 240 


Lys Ile Ala Gly Leu Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys 
                245                 250                 255     


Leu Glu Gln Asn Lys Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr 
            260                 265                 270         


Ile Lys Thr Asp Val Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val 
        275                 280                 285             


Gln Gln Pro Ala Ala Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu 
    290                 295                 300                 


Phe Lys Arg Trp Thr Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala 
305                 310                 315                 320 


Lys Gly Ala Lys Pro Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp 
                325                 330                 335     


Glu Ala Pro Glu Val Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val 
            340                 345                 350         


Thr Ile Leu Asp Glu Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu 
        355                 360                 365             


Lys Ala Pro Val Phe Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn 
    370                 375                 380                 


Ile Ser Ala Asn Leu Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val 
385                 390                 395                 400 


Ala Ala Tyr Ile Pro Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln 
                405                 410                 415     


Ile Ser Arg Glu Arg Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp 
            420                 425                 430         


Glu Lys Ala Leu Lys Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile 
        435                 440                 445             


Leu Ala Asn Tyr Gly Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met 
    450                 455                 460                 


Leu Glu Ser Tyr Ile Leu Asn Ser Val Ala Gly Arg His Asp Met Asp 
465                 470                 475                 480 


Ser Leu Ala Glu Arg Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu 
                485                 490                 495     


Ile Ala Gly Lys Gly Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu 
            500                 505                 510         


Glu Glu Ala Gly Arg Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln 
        515                 520                 525             


Leu His Leu Lys Met Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu 
    530                 535                 540                 


Asn Val Phe Glu Asn Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg 
545                 550                 555                 560 


Ile Glu Arg Asn Gly Val Lys Ile Asp Pro Lys Val Leu His Asn His 
                565                 570                 575     


Ser Glu Glu Leu Thr Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His 
            580                 585                 590         


Glu Ile Ala Gly Glu Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln 
        595                 600                 605             


Thr Ile Leu Phe Glu Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro 
    610                 615                 620                 


Gly Gly Ala Pro Ser Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu 
625                 630                 635                 640 


Asp Tyr Pro Leu Pro Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys 
                645                 650                 655     


Leu Lys Ser Thr Tyr Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys 
            660                 665                 670         


Thr Gly Arg Val His Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly 
        675                 680                 685             


Arg Leu Ser Ser Thr Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn 
    690                 695                 700                 


Glu Glu Gly Arg Arg Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr 
705                 710                 715                 720 


Val Ile Val Ser Ala Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala 
                725                 730                 735     


His Leu Ser Arg Asp Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys 
            740                 745                 750         


Asp Ile His Arg Ala Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu 
        755                 760                 765             


Thr Val Thr Ser Glu Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly 
    770                 775                 780                 


Leu Ile Tyr Gly Met Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile 
785                 790                 795                 800 


Pro Arg Lys Glu Ala Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr 
                805                 810                 815     


Pro Gly Val Leu Glu Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu 
            820                 825                 830         


Gln Gly Tyr Val Glu Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp 
        835                 840                 845             


Ile Lys Ser Ser Asn Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala 
    850                 855                 860                 


Ile Asn Ala Pro Met Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala 
865                 870                 875                 880 


Met Ile Ala Val Asp Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg 
                885                 890                 895     


Met Ile Met Gln Val His Asp Glu Leu Val Phe Glu Val His Lys Asp 
            900                 905                 910         


Asp Val Asp Ala Val Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys 
        915                 920                 925             


Thr Arg Leu Asp Val Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn 
    930                 935                 940                 


Trp Asp Gln Ala His Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
945                 950                 955                 960 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                965                 970 


<210>  93
<211>  1654
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg 
            20                  25                  30          


Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe 
        35                  40                  45              


Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg 
    50                  55                  60                  


Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala 
65                  70                  75                  80  


Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys 
                85                  90                  95      


Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg 
            100                 105                 110         


Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg 
        115                 120                 125             


Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu 
    130                 135                 140                 


Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln 
145                 150                 155                 160 


Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln 
                165                 170                 175     


Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu 
            180                 185                 190         


Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His 
        195                 200                 205             


Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His 
    210                 215                 220                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His 
225                 230                 235                 240 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                245                 250                 255     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn 
            260                 265                 270         


Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        275                 280                 285             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    290                 295                 300                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
305                 310                 315                 320 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                325                 330                 335     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            340                 345                 350         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        355                 360                 365             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
    370                 375                 380                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
385                 390                 395                 400 


Met Ser Leu Arg Ser Gly Gly Arg Arg Arg Ala Asp Pro Gly Ala Asp 
                405                 410                 415     


Gly Glu Ala Ser Arg Asp Asp Gly Ala Thr Ser Ser Val Ser Ala Leu 
            420                 425                 430         


Lys Arg Leu Glu Arg Ser Gln Trp Thr Asp Lys Met Asp Leu Arg Phe 
        435                 440                 445             


Gly Phe Glu Arg Leu Lys Glu Pro Gly Glu Lys Thr Gly Trp Leu Ile 
    450                 455                 460                 


Asn Met His Pro Thr Glu Ile Leu Asp Glu Asp Lys Arg Leu Gly Ser 
465                 470                 475                 480 


Ala Val Asp Tyr Tyr Phe Ile Gln Asp Asp Gly Ser Arg Phe Lys Val 
                485                 490                 495     


Ala Leu Pro Tyr Lys Pro Tyr Phe Tyr Ile Ala Thr Arg Lys Gly Cys 
            500                 505                 510         


Glu Arg Glu Val Ser Ser Phe Leu Ser Lys Lys Phe Gln Gly Lys Ile 
        515                 520                 525             


Ala Lys Val Glu Thr Val Pro Lys Glu Asp Leu Asp Leu Pro Asn His 
    530                 535                 540                 


Leu Val Gly Leu Lys Arg Asn Tyr Ile Arg Leu Ser Phe His Thr Val 
545                 550                 555                 560 


Glu Asp Leu Val Lys Val Arg Lys Glu Ile Ser Pro Ala Val Lys Lys 
                565                 570                 575     


Asn Arg Glu Gln Asp His Ala Ser Asp Ala Tyr Thr Ala Leu Leu Ser 
            580                 585                 590         


Ser Val Leu Gln Arg Gly Gly Val Ile Thr Asp Glu Glu Glu Thr Ser 
        595                 600                 605             


Lys Lys Ile Ala Asp Gln Leu Asp Asn Ile Val Asp Met Arg Glu Tyr 
    610                 615                 620                 


Asp Val Pro Tyr His Ile Arg Leu Ser Ile Asp Leu Lys Ile His Val 
625                 630                 635                 640 


Ala His Trp Tyr Asn Val Arg Tyr Arg Gly Asn Ala Phe Pro Val Glu 
                645                 650                 655     


Ile Thr Arg Arg Asp Asp Leu Val Glu Arg Pro Asp Pro Val Val Leu 
            660                 665                 670         


Ala Phe Asp Ile Glu Thr Thr Lys Leu Pro Leu Lys Phe Pro Asp Ala 
        675                 680                 685             


Glu Thr Asp Gln Ile Met Met Ile Ser Tyr Met Ile Asp Gly Gln Gly 
    690                 695                 700                 


Tyr Leu Ile Thr Asn Arg Glu Ile Val Ser Glu Asp Ile Glu Asp Phe 
705                 710                 715                 720 


Glu Phe Thr Pro Lys Pro Glu Tyr Glu Gly Pro Phe Cys Val Phe Asn 
                725                 730                 735     


Glu Pro Asp Glu Ala His Leu Ile Gln Arg Trp Phe Glu His Val Gln 
            740                 745                 750         


Glu Thr Lys Pro Thr Ile Met Val Thr Tyr Asn Gly Asp Phe Phe Asp 
        755                 760                 765             


Trp Pro Phe Val Glu Ala Arg Ala Ala Val His Gly Leu Ser Met Gln 
    770                 775                 780                 


Gln Glu Ile Gly Phe Gln Lys Asp Ser Gln Gly Glu Tyr Lys Ala Pro 
785                 790                 795                 800 


Gln Cys Ile His Met Asp Cys Leu Arg Trp Val Lys Arg Asp Ser Tyr 
                805                 810                 815     


Leu Pro Val Gly Ser His Asn Leu Lys Ala Ala Ala Lys Ala Lys Leu 
            820                 825                 830         


Gly Tyr Asp Pro Val Glu Leu Asp Pro Glu Asp Met Cys Arg Met Ala 
        835                 840                 845             


Thr Glu Gln Pro Gln Thr Leu Ala Thr Tyr Ser Val Ser Asp Ala Val 
    850                 855                 860                 


Ala Thr Tyr Tyr Leu Tyr Met Lys Tyr Val His Pro Phe Ile Phe Ala 
865                 870                 875                 880 


Leu Cys Thr Ile Ile Pro Met Glu Pro Asp Glu Val Leu Arg Lys Gly 
                885                 890                 895     


Ser Gly Thr Leu Cys Glu Ala Leu Leu Met Val Gln Ala Phe His Ala 
            900                 905                 910         


Asn Ile Ile Phe Pro Asn Lys Gln Glu Gln Glu Phe Asn Lys Leu Thr 
        915                 920                 925             


Asp Asp Gly His Val Leu Asp Ser Glu Thr Tyr Val Gly Gly His Val 
    930                 935                 940                 


Glu Ala Leu Glu Ser Gly Val Phe Arg Ser Asp Ile Pro Cys Arg Phe 
945                 950                 955                 960 


Arg Met Asn Pro Ala Ala Phe Asp Phe Leu Leu Gln Arg Val Glu Lys 
                965                 970                 975     


Thr Leu Arg His Ala Leu Glu Glu Glu Glu Lys Val Pro Val Glu Gln 
            980                 985                 990         


Val Thr Asn Phe Glu Glu Val Cys  Asp Glu Ile Lys Ser  Lys Leu Ala 
        995                 1000                 1005             


Ser Leu  Lys Asp Val Pro Ser  Arg Ile Glu Cys Pro  Leu Ile Tyr 
    1010                 1015                 1020             


His Leu  Asp Val Gly Ala Met  Tyr Pro Asn Ile Ile  Leu Thr Asn 
    1025                 1030                 1035             


Arg Leu  Gln Pro Ser Ala Met  Val Asp Glu Ala Thr  Cys Ala Ala 
    1040                 1045                 1050             


Cys Asp  Phe Asn Lys Pro Gly  Ala Asn Cys Gln Arg  Lys Met Ala 
    1055                 1060                 1065             


Trp Gln  Trp Arg Gly Glu Phe  Met Pro Ala Ser Arg  Ser Glu Tyr 
    1070                 1075                 1080             


His Arg  Ile Gln His Gln Leu  Glu Ser Glu Lys Phe  Pro Pro Leu 
    1085                 1090                 1095             


Phe Pro  Glu Gly Pro Ala Arg  Ala Phe His Glu Leu  Ser Arg Glu 
    1100                 1105                 1110             


Glu Gln  Ala Lys Tyr Glu Lys  Arg Arg Leu Ala Asp  Tyr Cys Arg 
    1115                 1120                 1125             


Lys Ala  Tyr Lys Lys Ile His  Ile Thr Lys Val Glu  Glu Arg Leu 
    1130                 1135                 1140             


Thr Thr  Ile Cys Gln Arg Glu  Asn Ser Phe Tyr Val  Asp Thr Val 
    1145                 1150                 1155             


Arg Ala  Phe Arg Asp Arg Arg  Tyr Glu Phe Lys Gly  Leu His Lys 
    1160                 1165                 1170             


Val Trp  Lys Lys Lys Leu Ser  Ala Ala Val Glu Val  Gly Asp Ala 
    1175                 1180                 1185             


Ala Glu  Val Lys Arg Cys Lys  Asn Met Glu Val Leu  Tyr Asp Ser 
    1190                 1195                 1200             


Leu Gln  Leu Ala His Lys Cys  Ile Leu Asn Ser Phe  Tyr Gly Tyr 
    1205                 1210                 1215             


Val Met  Arg Lys Gly Ala Arg  Trp Tyr Ser Met Glu  Met Ala Gly 
    1220                 1225                 1230             


Ile Val  Cys Phe Thr Gly Ala  Asn Ile Ile Thr Gln  Ala Arg Glu 
    1235                 1240                 1245             


Leu Ile  Glu Gln Ile Gly Arg  Pro Leu Glu Leu Asp  Thr Asp Gly 
    1250                 1255                 1260             


Ile Trp  Cys Val Leu Pro Asn  Ser Phe Pro Glu Asn  Phe Val Phe 
    1265                 1270                 1275             


Lys Thr  Thr Asn Val Lys Lys  Pro Lys Val Thr Ile  Ser Tyr Pro 
    1280                 1285                 1290             


Gly Ala  Met Leu Asn Ile Met  Val Lys Glu Gly Phe  Thr Asn Asp 
    1295                 1300                 1305             


Gln Tyr  Gln Glu Leu Ala Glu  Pro Ser Ser Leu Thr  Tyr Val Thr 
    1310                 1315                 1320             


Arg Ser  Glu Asn Ser Ile Phe  Phe Glu Val Asp Gly  Pro Tyr Leu 
    1325                 1330                 1335             


Ala Met  Ile Leu Pro Ala Ser  Lys Glu Glu Gly Lys  Lys Leu Lys 
    1340                 1345                 1350             


Lys Arg  Tyr Ala Val Phe Asn  Glu Asp Gly Ser Leu  Ala Glu Leu 
    1355                 1360                 1365             


Lys Gly  Phe Glu Val Lys Arg  Arg Gly Glu Leu Gln  Leu Ile Lys 
    1370                 1375                 1380             


Ile Phe  Gln Ser Ser Val Phe  Glu Ala Phe Leu Lys  Gly Ser Thr 
    1385                 1390                 1395             


Leu Glu  Glu Val Tyr Gly Ser  Val Ala Lys Val Ala  Asp Tyr Trp 
    1400                 1405                 1410             


Leu Asp  Val Leu Tyr Ser Lys  Ala Ala Asn Met Pro  Asp Ser Glu 
    1415                 1420                 1425             


Leu Phe  Glu Leu Ile Ser Glu  Asn Arg Ser Met Ser  Arg Lys Leu 
    1430                 1435                 1440             


Glu Asp  Tyr Gly Glu Gln Lys  Ser Thr Ser Ile Ser  Thr Ala Lys 
    1445                 1450                 1455             


Arg Leu  Ala Glu Phe Leu Gly  Asp Gln Met Val Lys  Asp Ala Gly 
    1460                 1465                 1470             


Leu Ser  Cys Arg Tyr Ile Ile  Ser Arg Lys Pro Glu  Gly Ser Pro 
    1475                 1480                 1485             


Val Thr  Glu Arg Ala Ile Pro  Leu Ala Ile Phe Gln  Ala Glu Pro 
    1490                 1495                 1500             


Thr Val  Arg Lys His Phe Leu  Arg Lys Trp Leu Lys  Ser Ser Ser 
    1505                 1510                 1515             


Leu Gln  Asp Phe Asp Ile Arg  Ala Ile Leu Asp Trp  Asp Tyr Tyr 
    1520                 1525                 1530             


Ile Glu  Arg Leu Gly Ser Ala  Ile Gln Lys Ile Ile  Thr Ile Pro 
    1535                 1540                 1545             


Ala Ala  Leu Gln Gln Val Lys  Asn Pro Val Pro Arg  Val Lys His 
    1550                 1555                 1560             


Pro Asp  Trp Leu His Lys Lys  Leu Leu Glu Lys Asn  Asp Val Tyr 
    1565                 1570                 1575             


Lys Gln  Lys Lys Ile Ser Glu  Leu Phe Thr Leu Glu  Gly Arg Arg 
    1580                 1585                 1590             


Gln Val  Thr Met Ala Glu Ala  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1595                 1600                 1605             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser 
    1610                 1615                 1620             


Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln Ala Gly  Asp Val Glu 
    1625                 1630                 1635             


Glu Asn  Pro Gly Pro Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1640                 1645                 1650             


Val 
    


<210>  94
<211>  1233
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  94

Met Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Ser Gly Met Phe Gly Lys Lys Lys 
            20                  25                  30          


Asn Asn Gly Gly Ser Ser Thr Ala Arg Tyr Ser Ala Gly Asn Lys Tyr 
        35                  40                  45              


Asn Thr Leu Ser Asn Asn Tyr Ala Leu Ser Ala Gln Gln Leu Leu Asn 
    50                  55                  60                  


Ala Ser Lys Ile Asp Asp Ile Asp Ser Met Met Gly Phe Glu Arg Tyr 
65                  70                  75                  80  


Val Pro Pro Gln Tyr Asn Gly Arg Phe Asp Ala Lys Asp Ile Asp Gln 
                85                  90                  95      


Ile Pro Gly Arg Val Gly Trp Leu Thr Asn Met His Ala Thr Leu Val 
            100                 105                 110         


Ser Gln Glu Thr Leu Ser Ser Gly Ser Asn Gly Gly Gly Asn Ser Asn 
        115                 120                 125             


Asp Gly Glu Arg Val Thr Thr Asn Gln Gly Ile Ser Gly Val Asp Phe 
    130                 135                 140                 


Tyr Phe Leu Asp Glu Glu Gly Gly Ser Phe Lys Ser Thr Val Val Tyr 
145                 150                 155                 160 


Asp Pro Tyr Phe Phe Ile Ala Cys Asn Asp Glu Ser Arg Val Asn Asp 
                165                 170                 175     


Val Glu Glu Leu Val Lys Lys Tyr Leu Glu Ser Cys Leu Lys Ser Leu 
            180                 185                 190         


Gln Ile Ile Arg Lys Glu Asp Leu Thr Met Asp Asn His Leu Leu Gly 
        195                 200                 205             


Leu Gln Lys Thr Leu Ile Lys Leu Ser Phe Val Asn Ser Asn Gln Leu 
    210                 215                 220                 


Phe Glu Ala Arg Lys Leu Leu Arg Pro Ile Leu Gln Asp Asn Ala Asn 
225                 230                 235                 240 


Asn Asn Val Gln Arg Asn Ile Tyr Asn Val Ala Ala Asn Gly Ser Glu 
                245                 250                 255     


Lys Val Asp Ala Lys His Leu Ile Glu Asp Ile Arg Glu Tyr Asp Val 
            260                 265                 270         


Pro Tyr His Val Arg Val Ser Ile Asp Lys Asp Ile Arg Val Gly Lys 
        275                 280                 285             


Trp Tyr Lys Val Thr Gln Gln Gly Phe Ile Glu Asp Thr Arg Lys Ile 
    290                 295                 300                 


Ala Phe Ala Asp Pro Val Val Met Ala Phe Asp Ile Glu Thr Thr Lys 
305                 310                 315                 320 


Pro Pro Leu Lys Phe Pro Asp Ser Ala Val Asp Gln Ile Met Met Ile 
                325                 330                 335     


Ser Tyr Met Ile Asp Gly Glu Gly Phe Leu Ile Thr Asn Arg Glu Ile 
            340                 345                 350         


Ile Ser Glu Asp Ile Glu Asp Phe Glu Tyr Thr Pro Lys Pro Glu Tyr 
        355                 360                 365             


Pro Gly Phe Phe Thr Ile Phe Asn Glu Asn Asp Glu Val Ala Leu Leu 
    370                 375                 380                 


Gln Arg Phe Phe Glu His Ile Arg Asp Val Arg Pro Thr Val Ile Ser 
385                 390                 395                 400 


Thr Phe Asn Gly Asp Phe Phe Asp Trp Pro Phe Ile His Asn Arg Ser 
                405                 410                 415     


Lys Ile His Gly Leu Asp Met Phe Asp Glu Ile Gly Phe Ala Pro Asp 
            420                 425                 430         


Ala Glu Gly Glu Tyr Lys Ser Ser Tyr Cys Ser His Met Asp Cys Phe 
        435                 440                 445             


Arg Trp Val Lys Arg Asp Ser Tyr Leu Pro Gln Gly Ser Gln Gly Leu 
    450                 455                 460                 


Lys Ala Val Thr Gln Ser Lys Leu Gly Tyr Asn Pro Ile Glu Leu Asp 
465                 470                 475                 480 


Pro Glu Leu Met Thr Pro Tyr Ala Phe Glu Lys Pro Gln His Leu Ser 
                485                 490                 495     


Glu Tyr Ser Val Ser Asp Ala Val Ala Thr Tyr Tyr Leu Tyr Met Lys 
            500                 505                 510         


Tyr Val His Pro Phe Ile Phe Ser Leu Cys Thr Ile Ile Pro Leu Asn 
        515                 520                 525             


Pro Asp Glu Thr Leu Arg Lys Gly Thr Gly Thr Leu Cys Glu Met Leu 
    530                 535                 540                 


Leu Met Val Gln Ala Tyr Gln His Asn Ile Leu Leu Pro Asn Lys His 
545                 550                 555                 560 


Thr Asp Pro Ile Glu Arg Phe Tyr Asp Gly His Leu Leu Glu Ser Glu 
                565                 570                 575     


Thr Tyr Val Gly Gly His Val Glu Ser Leu Glu Ala Gly Val Phe Arg 
            580                 585                 590         


Ser Asp Leu Lys Asn Glu Phe Lys Ile Asp Pro Ser Ala Ile Asp Glu 
        595                 600                 605             


Leu Leu Gln Glu Leu Pro Glu Ala Leu Lys Phe Ser Val Glu Val Glu 
    610                 615                 620                 


Asn Lys Ser Ser Val Asp Lys Val Thr Asn Phe Glu Glu Ile Lys Asn 
625                 630                 635                 640 


Gln Ile Thr Gln Lys Leu Leu Glu Leu Lys Glu Asn Asn Ile Arg Asn 
                645                 650                 655     


Glu Leu Pro Leu Ile Tyr His Val Asp Val Ala Ser Met Tyr Pro Asn 
            660                 665                 670         


Ile Met Thr Thr Asn Arg Leu Gln Pro Asp Ser Ile Lys Ala Glu Arg 
        675                 680                 685             


Asp Cys Ala Ser Cys Asp Phe Asn Arg Pro Gly Lys Thr Cys Ala Arg 
    690                 695                 700                 


Lys Leu Lys Trp Ala Trp Arg Gly Glu Phe Phe Pro Ser Lys Met Asp 
705                 710                 715                 720 


Glu Tyr Asn Met Ile Lys Arg Ala Leu Gln Asn Glu Thr Phe Pro Asn 
                725                 730                 735     


Lys Asn Lys Phe Ser Lys Lys Lys Val Leu Thr Phe Asp Glu Leu Ser 
            740                 745                 750         


Tyr Ala Asp Gln Val Ile His Ile Lys Lys Arg Leu Thr Glu Tyr Ser 
        755                 760                 765             


Arg Lys Val Tyr His Arg Val Lys Val Ser Glu Ile Val Glu Arg Glu 
    770                 775                 780                 


Ala Ile Val Cys Gln Arg Glu Asn Pro Phe Tyr Val Asp Thr Val Lys 
785                 790                 795                 800 


Ser Phe Arg Asp Arg Arg Tyr Glu Phe Lys Gly Leu Ala Lys Thr Trp 
                805                 810                 815     


Lys Gly Asn Leu Ser Lys Ile Asp Pro Ser Asp Lys His Ala Arg Asp 
            820                 825                 830         


Glu Ala Lys Lys Met Ile Val Leu Tyr Asp Ser Leu Gln Leu Ala His 
        835                 840                 845             


Lys Val Ile Leu Asn Ser Phe Tyr Gly Tyr Val Met Arg Lys Gly Ser 
    850                 855                 860                 


Arg Trp Tyr Ser Met Glu Met Ala Gly Ile Thr Cys Leu Thr Gly Ala 
865                 870                 875                 880 


Thr Ile Ile Gln Met Ala Arg Ala Leu Val Glu Arg Val Gly Arg Pro 
                885                 890                 895     


Leu Glu Leu Asp Thr Asp Gly Ile Trp Cys Ile Leu Pro Lys Ser Phe 
            900                 905                 910         


Pro Glu Thr Tyr Phe Phe Thr Leu Glu Asn Gly Lys Lys Leu Tyr Leu 
        915                 920                 925             


Ser Tyr Pro Cys Ser Met Leu Asn Tyr Arg Val His Gln Lys Phe Thr 
    930                 935                 940                 


Asn His Gln Tyr Gln Glu Leu Lys Asp Pro Leu Asn Tyr Ile Tyr Glu 
945                 950                 955                 960 


Thr His Ser Glu Asn Thr Ile Phe Phe Glu Val Asp Gly Pro Tyr Lys 
                965                 970                 975     


Ala Met Ile Leu Pro Ser Ser Lys Glu Glu Gly Lys Gly Ile Lys Lys 
            980                 985                 990         


Arg Tyr Ala Val Phe Asn Glu Asp  Gly Ser Leu Ala Glu  Leu Lys Gly 
        995                 1000                 1005             


Phe Glu  Leu Lys Arg Arg Gly  Glu Leu Gln Leu Ile  Lys Asn Phe 
    1010                 1015                 1020             


Gln Ser  Asp Ile Phe Lys Val  Phe Leu Glu Gly Asp  Thr Leu Glu 
    1025                 1030                 1035             


Gly Cys  Tyr Ser Ala Val Ala  Ser Val Cys Asn Arg  Trp Leu Asp 
    1040                 1045                 1050             


Val Leu  Asp Ser His Gly Leu  Met Leu Glu Asp Glu  Asp Leu Val 
    1055                 1060                 1065             


Ser Leu  Ile Cys Glu Asn Arg  Ser Met Ser Lys Thr  Leu Lys Glu 
    1070                 1075                 1080             


Tyr Glu  Gly Gln Lys Ser Thr  Ser Ile Thr Thr Ala  Arg Arg Leu 
    1085                 1090                 1095             


Gly Asp  Phe Leu Gly Glu Asp  Met Val Lys Asp Lys  Gly Leu Gln 
    1100                 1105                 1110             


Cys Lys  Tyr Ile Ile Ser Ser  Lys Pro Phe Asn Ala  Pro Val Thr 
    1115                 1120                 1125             


Glu Arg  Ala Ile Pro Val Ala  Ile Phe Ser Ala Asp  Ile Pro Ile 
    1130                 1135                 1140             


Lys Arg  Ser Phe Leu Arg Arg  Trp Thr Leu Asp Pro  Ser Leu Glu 
    1145                 1150                 1155             


Asp Leu  Asp Ile Arg Thr Ile  Ile Asp Trp Gly Tyr  Tyr Arg Glu 
    1160                 1165                 1170             


Arg Leu  Gly Ser Ala Ile Gln  Lys Ile Ile Thr Ile  Pro Ala Ala 
    1175                 1180                 1185             


Leu Gln  Gly Val Ser Asn Pro  Val Pro Arg Val Glu  His Pro Asp 
    1190                 1195                 1200             


Trp Leu  Lys Arg Lys Ile Ala  Thr Lys Ser Gly Gly  Ser Lys Arg 
    1205                 1210                 1215             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1220                 1225                 1230             


