                         SEQUENCE LISTING

<110>  ̩＼޹˾
       Ŵѧ
 
<120>  ڼHBcAgķ

<130>  IEC200405PCT

<150>  CN202010059190.X
<151>  2020-01-19

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 VH

<400>  1

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asp Tyr 
            20                  25                  30          


Pro Val His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Asp His Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  2
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 VL

<400>  2

Asp Ile Val Ile Thr Gln Asp Glu Leu Ser Asn Pro Val Thr Ser Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu 
                85                  90                  95      


Val Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 HCDR1

<400>  3

Gly Tyr Ala Phe Thr Asp Tyr Pro 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 HCDR2

<400>  4

Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  5
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 HCDR3

<400>  5

Asp His Tyr Ser Met Asp Tyr 
1               5           


<210>  6
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 LCDR1

<400>  6

Lys Ser Leu Leu Tyr Lys Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  7
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 LCDR2

<400>  7

Leu Met Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  18B2-2 LCDR3

<400>  8

Gln Gln Leu Val Glu Tyr Pro Phe Thr 
1               5                   


<210>  9
<211>  122
<212>  PRT
<213>  ˹

<220>
<223>  2A7 VH

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Met Gln Arg Pro Gly Gln Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Ile Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Glu Gly Tyr Arg Asn Asp Tyr Tyr Tyr Ala Met Asp Phe Trp 
            100                 105                 110         


Gly Arg Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  2A7 VL

<400>  10

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Lys Gln Lys Thr Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Tyr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  2A7 HCDR1

<400>  11

Gly Tyr Thr Phe Thr Arg Tyr Trp 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  2A7 HCDR2

<400>  12

Ile Asn Pro Ile Asn Gly Arg Thr 
1               5               


<210>  13
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  2A7 HCDR3

<400>  13

Thr Arg Glu Gly Tyr Arg Asn Asp Tyr Tyr Tyr Ala Met Asp Phe 
1               5                   10                  15  


<210>  14
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  2A7 LCDR1

<400>  14

Gln Gly Ile Asn Asn Tyr 
1               5       


<210>  15
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  2A7 LCDR2

<400>  15

Tyr Thr Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  2A7 LCDR3

<400>  16

Gln Gln Tyr Gly Lys Leu Pro Trp Thr 
1               5                   


<210>  17
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  C183

<400>  17

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser 
                165                 170                 175     


Gln Ser Arg Glu Ser Gln Cys 
            180             


<210>  18
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S1

<400>  18

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S2

<400>  19

Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S3

<400>  20

Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S4

<400>  21

Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S5

<400>  22

Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S6

<400>  23

Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S7

<400>  24

Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S8

<400>  25

Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S9

<400>  26

Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr Ala Leu 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S10

<400>  27

Glu His Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S11

<400>  28

His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S12

<400>  29

Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Asn Leu Ala Thr 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S13

<400>  30

Cys Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val Gly Val Asn 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S14

<400>  31

Met Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S15

<400>  32

Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S16

<400>  33

Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val Ser Tyr Val Asn 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S17

<400>  34

Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S18

<400>  35

Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S19

<400>  36

Thr Asn Met Gly Leu Lys Phe Arg Gln Leu Leu Trp Phe His Ile 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S20

<400>  37

Lys Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S21

<400>  38

Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S22

<400>  39

Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile Glu Tyr Leu Val 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S23

<400>  40

Gly Arg Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S24

<400>  41

Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S25

<400>  42

Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S26

<400>  43

Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S27

<400>  44

Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  S28

<400>  45

Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg 
1               5                   10                  15  


<210>  46
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  S29

<400>  46

Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg 
1               5                   10                  


<210>  47
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  S30

<400>  47

Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg 
1               5                   10          


<210>  48
<211>  34
<212>  PRT
<213>  ˹

<220>
<223>  S31

<400>  48

Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg 
1               5                   10                  15      


Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser 
            20                  25                  30          


Gln Cys 
        


