                         SEQUENCE LISTING

<110>  ѧо
 
<120>  ͸ײȾӼӦ

<130>  RYP2016271.9

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Thr Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu 
    50                  55                  60                  


Ser Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp 
65                  70                  75                  80  


Ser Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp 
                85                  90                  95      


Pro Gln Asp Thr Pro Pro Arg Ser Gly Pro Ala Thr Ser Pro Ala Gly 
            100                 105                 110         


Cys His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro 
        115                 120                 125             


Gly Asn Ser Cys Ser Thr Thr Thr Pro Gly Pro Val Ile Gln Val Pro 
    130                 135                 140                 


Glu Ala Ser Val Thr Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg 
145                 150                 155                 160 


Ile Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys 
                165                 170                 175     


Asn Leu Thr Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu 
            180                 185                 190         


Gln Gln His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly 
        195                 200                 205             


His Cys Gln Glu Leu Val Leu Thr Glu Asp Glu Lys Lys Leu Leu Ala 
    210                 215                 220                 


Lys Glu Gly Ile Thr Leu Pro Thr Gln Leu Pro Leu Thr Lys Tyr Glu 
225                 230                 235                 240 


Glu Arg Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser 
                245                 250                 255     


Ala Gln Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu 
            260                 265                 270         


Thr Arg Met Ser Ala Cys Thr Ala Gln Asn Gln Glu Leu Gln Arg Lys 
        275                 280                 285             


Val Leu His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys 
    290                 295                 300                 


Lys Leu Gln Ala Ile Val Val Gln Ser Thr Ser Lys Ser Ala Gln Thr 
305                 310                 315                 320 


Gly Thr Cys Val Ala Val Leu Leu Leu Ser Phe Ala Leu Ile Ile Leu 
                325                 330                 335     


Pro Ser Ile Ser Pro Phe Gly Pro Asn Lys Thr Glu Ser Pro Gly Asp 
            340                 345                 350         


Phe Ala Pro Val Arg Val Phe Ser Arg Thr Leu His Asn Asp Ala Ala 
        355                 360                 365             


Ser Arg Val Ala Ala Asp Ala Val Pro Gly Ser Glu Ala Pro Gly Pro 
    370                 375                 380                 


Arg Pro Glu Ala Asp Thr Thr Arg Glu Glu Ser Pro Gly Ser Pro Gly 
385                 390                 395                 400 


Ala Asp Trp Gly Phe Gln Asp Thr Ala Asn Leu Thr Asn Ser Thr Glu 
                405                 410                 415     


Glu Leu Asp Asn Ala Thr Leu Val Leu Arg Asn Ala Thr Glu Gly Leu 
            420                 425                 430         


Gly Gln Val Ala Leu Leu Asp Trp Val Ala Pro Gly Pro Ser Thr Gly 
        435                 440                 445             


Ser Gly Arg Ala Gly Leu Glu Ala Ala Gly Asp Glu Leu 
    450                 455                 460     


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREBH-122

<400>  2

Met Asn Thr Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu 
    50                  55                  60                  


Ser Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp 
65                  70                  75                  80  


Ser Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp 
                85                  90                  95      


Pro Gln Asp Thr Pro Pro Arg Ser Gly Pro Ala Thr Ser Pro Ala Gly 
            100                 105                 110         


Cys His Pro Ala Gln Pro Gly Lys Gly Pro 
        115                 120         


<210>  3
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREBH-122-318

<400>  3

Pro Cys Leu Ser Tyr His Pro Gly Asn Ser Cys Ser Thr Thr Thr Pro 
1               5                   10                  15      


Gly Pro Val Ile Gln Val Pro Glu Ala Ser Val Thr Ile Asp Leu Glu 
            20                  25                  30          


Met Trp Ser Pro Gly Gly Arg Ile Cys Ala Glu Lys Pro Ala Asp Pro 
        35                  40                  45              


Val Asp Leu Ser Pro Arg Cys Asn Leu Thr Val Lys Asp Leu Leu Leu 
    50                  55                  60                  


Ser Gly Ser Ser Gly Asp Leu Gln Gln His His Leu Gly Ala Ser Tyr 
65                  70                  75                  80  


Leu Leu Arg Pro Gly Ala Gly His Cys Gln Glu Leu Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Lys Lys Leu Leu Ala Lys Glu Gly Ile Thr Leu Pro Thr Gln 
            100                 105                 110         


Leu Pro Leu Thr Lys Tyr Glu Glu Arg Val Leu Lys Lys Ile Arg Arg 
        115                 120                 125             


Lys Ile Arg Asn Lys Gln Ser Ala Gln Glu Ser Arg Lys Lys Lys Lys 
    130                 135                 140                 


Glu Tyr Ile Asp Gly Leu Glu Thr Arg Met Ser Ala Cys Thr Ala Gln 
145                 150                 155                 160 


Asn Gln Glu Leu Gln Arg Lys Val Leu His Leu Glu Lys Gln Asn Leu 
                165                 170                 175     


Ser Leu Leu Glu Gln Leu Lys Lys Leu Gln Ala Ile Val Val Gln Ser 
            180                 185                 190         


Thr Ser Lys Ser Ala 
        195         


<210>  4
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREBH-211-318

<400>  4

Gln Glu Leu Val Leu Thr Glu Asp Glu Lys Lys Leu Leu Ala Lys Glu 
1               5                   10                  15      


Gly Ile Thr Leu Pro Thr Gln Leu Pro Leu Thr Lys Tyr Glu Glu Arg 
            20                  25                  30          


Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser Ala Gln 
        35                  40                  45              


Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu Thr Arg 
    50                  55                  60                  


Met Ser Ala Cys Thr Ala Gln Asn Gln Glu Leu Gln Arg Lys Val Leu 
65                  70                  75                  80  


His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys Lys Leu 
                85                  90                  95      


Gln Ala Ile Val Val Gln Ser Thr Ser Lys Ser Ala 
            100                 105             


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siCREBH -1

<400>  5
gcugcuggaa agauggcuu                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siCREBH -2

<400>  6
gcuccuggau cuccuguuu                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siCREBH -3

<400>  7
cccucuugga gcaacugaa                                                    19


<210>  8
<211>  871
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Gly Ala Gly Pro Arg Gly Ala Gly Pro Ala Arg Arg Arg Gly 
1               5                   10                  15      


Ala Gly Gly Pro Pro Ser Pro Leu Leu Pro Ser Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Trp Met Leu Pro Asp Thr Val Ala Pro Gln Glu Leu Asn Pro 
        35                  40                  45              


Arg Gly Arg Asn Val Cys Arg Ala Pro Gly Ser Gln Val Pro Thr Cys 
    50                  55                  60                  


Cys Ala Gly Trp Arg Gln Gln Gly Asp Glu Cys Gly Ile Ala Val Cys 
65                  70                  75                  80  


Glu Gly Asn Ser Thr Cys Ser Glu Asn Glu Val Cys Val Arg Pro Gly 
                85                  90                  95      


Glu Cys Arg Cys Arg His Gly Tyr Phe Gly Ala Asn Cys Asp Thr Lys 
            100                 105                 110         


Cys Pro Arg Gln Phe Trp Gly Pro Asp Cys Lys Glu Leu Cys Ser Cys 
        115                 120                 125             


His Pro His Gly Gln Cys Glu Asp Val Thr Gly Gln Cys Thr Cys His 
    130                 135                 140                 


Ala Arg Arg Trp Gly Ala Arg Cys Glu His Ala Cys Gln Cys Gln His 
145                 150                 155                 160 


Gly Thr Cys His Pro Arg Ser Gly Ala Cys Arg Cys Glu Pro Gly Trp 
                165                 170                 175     


Trp Gly Ala Gln Cys Ala Ser Ala Cys Tyr Cys Ser Ala Thr Ser Arg 
            180                 185                 190         


Cys Asp Pro Gln Thr Gly Ala Cys Leu Cys His Ala Gly Trp Trp Gly 
        195                 200                 205             


Arg Ser Cys Asn Asn Gln Cys Ala Cys Asn Ser Ser Pro Cys Glu Gln 
    210                 215                 220                 


Gln Ser Gly Arg Cys Gln Cys Arg Glu Arg Thr Phe Gly Ala Arg Cys 
225                 230                 235                 240 


Asp Arg Tyr Cys Gln Cys Phe Arg Gly Arg Cys His Pro Val Asp Gly 
                245                 250                 255     


Thr Cys Ala Cys Glu Pro Gly Tyr Arg Gly Lys Tyr Cys Arg Glu Pro 
            260                 265                 270         


Cys Pro Ala Gly Phe Tyr Gly Leu Gly Cys Arg Arg Arg Cys Gly Gln 
        275                 280                 285             


Cys Lys Gly Gln Gln Pro Cys Thr Val Ala Glu Gly Arg Cys Leu Thr 
    290                 295                 300                 


Cys Glu Pro Gly Trp Asn Gly Thr Lys Cys Asp Gln Pro Cys Ala Thr 
305                 310                 315                 320 


Gly Phe Tyr Gly Glu Gly Cys Ser His Arg Cys Pro Pro Cys Arg Asp 
                325                 330                 335     


Gly His Ala Cys Asn His Val Thr Gly Lys Cys Thr Arg Cys Asn Ala 
            340                 345                 350         


Gly Trp Ile Gly Asp Arg Cys Glu Thr Lys Cys Ser Asn Gly Thr Tyr 
        355                 360                 365             


Gly Glu Asp Cys Ala Phe Val Cys Ala Asp Cys Gly Ser Gly His Cys 
    370                 375                 380                 


Asp Phe Gln Ser Gly Arg Cys Leu Cys Ser Pro Gly Val His Gly Pro 
385                 390                 395                 400 


His Cys Asn Val Thr Cys Pro Pro Gly Leu His Gly Ala Asp Cys Ala 
                405                 410                 415     


Gln Ala Cys Ser Cys His Glu Asp Thr Cys Asp Pro Val Thr Gly Ala 
            420                 425                 430         


Cys His Leu Glu Thr Asn Gln Arg Lys Gly Val Met Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Val Leu Leu Val Cys Leu Leu Leu Ser Leu Leu Gly Cys Cys 
    450                 455                 460                 


Cys Ala Cys Arg Gly Lys Asp Pro Thr Arg Arg Pro Arg Pro Arg Arg 
465                 470                 475                 480 


Glu Leu Ser Leu Gly Arg Lys Lys Ala Pro His Arg Leu Cys Gly Arg 
                485                 490                 495     


Phe Ser Arg Ile Ser Met Lys Leu Pro Arg Ile Pro Leu Arg Arg Gln 
            500                 505                 510         


Lys Leu Pro Lys Val Val Val Ala His His Asp Leu Asp Asn Thr Leu 
        515                 520                 525             


Asn Cys Ser Phe Leu Glu Pro Pro Ser Gly Leu Glu Gln Pro Ser Pro 
    530                 535                 540                 


Ser Trp Ser Ser Arg Ala Ser Phe Ser Ser Phe Asp Thr Thr Asp Glu 
545                 550                 555                 560 


Gly Pro Val Tyr Cys Val Pro His Glu Glu Ala Pro Ala Glu Ser Arg 
                565                 570                 575     


Asp Pro Glu Val Pro Thr Val Pro Ala Glu Ala Pro Ala Pro Ser Pro 
            580                 585                 590         


Val Pro Leu Thr Thr Pro Ala Ser Ala Glu Glu Ala Ile Pro Leu Pro 
        595                 600                 605             


Ala Ser Ser Asp Ser Glu Arg Ser Ala Ser Ser Val Glu Gly Pro Gly 
    610                 615                 620                 


Gly Ala Leu Tyr Ala Arg Val Ala Arg Arg Glu Ala Arg Pro Ala Arg 
625                 630                 635                 640 


Ala Arg Gly Glu Ile Gly Gly Leu Ser Leu Ser Pro Ser Pro Glu Arg 
                645                 650                 655     


Arg Lys Pro Pro Pro Pro Asp Pro Ala Thr Lys Pro Lys Val Ser Trp 
            660                 665                 670         


Ile His Gly Lys His Ser Ala Ala Ala Ala Gly Arg Ala Pro Ser Pro 
        675                 680                 685             


Pro Pro Pro Gly Ser Glu Ala Ala Pro Ser Pro Ser Lys Arg Lys Arg 
    690                 695                 700                 


Thr Pro Ser Asp Lys Ser Ala His Thr Val Glu His Gly Ser Pro Arg 
705                 710                 715                 720 


Thr Arg Asp Pro Thr Pro Arg Pro Pro Gly Leu Pro Glu Glu Ala Thr 
                725                 730                 735     


Ala Leu Ala Ala Pro Ser Pro Pro Arg Ala Arg Ala Arg Gly Arg Gly 
            740                 745                 750         


Pro Gly Leu Leu Glu Pro Thr Asp Ala Gly Gly Pro Pro Arg Ser Ala 
        755                 760                 765             


Pro Glu Ala Ala Ser Met Leu Ala Ala Glu Leu Arg Gly Lys Thr Arg 
    770                 775                 780                 


Ser Leu Gly Arg Ala Glu Val Ala Leu Gly Ala Gln Gly Pro Arg Glu 
785                 790                 795                 800 


Lys Pro Ala Pro Pro Gln Lys Ala Lys Arg Ser Val Pro Pro Ala Ser 
                805                 810                 815     


Pro Ala Arg Ala Pro Pro Ala Thr Glu Thr Pro Gly Pro Glu Lys Ala 
            820                 825                 830         


Ala Thr Asp Leu Pro Ala Pro Glu Thr Pro Arg Lys Lys Thr Pro Ile 
        835                 840                 845             


Gln Lys Pro Pro Arg Lys Lys Ser Arg Glu Ala Ala Gly Glu Leu Gly 
    850                 855                 860                 


Arg Ala Gly Ala Pro Thr Leu 
865                 870     


<210>  9
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCARF2 ˱Ƥṹ򰱻УEGF like 1-7

<400>  9

Gln Gly Asp Glu Cys Gly Ile Ala Val Cys Glu Gly Asn Ser Thr Cys 
1               5                   10                  15      


Ser Glu Asn Glu Val Cys Val Arg Pro Gly Glu Cys Arg Cys Arg His 
            20                  25                  30          


Gly Tyr Phe Gly Ala Asn Cys Asp Thr Lys Cys Pro Arg Gln Phe Trp 
        35                  40                  45              


Gly Pro Asp Cys Lys Glu Leu Cys Ser Cys His Pro His Gly Gln Cys 
    50                  55                  60                  


Glu Asp Val Thr Gly Gln Cys Thr Cys His Ala Arg Arg Trp Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Cys Gln Cys Gln His Gly Thr Cys His Pro Arg 
                85                  90                  95      


Ser Gly Ala Cys Arg Cys Glu Pro Gly Trp Trp Gly Ala Gln Cys Ala 
            100                 105                 110         


Ser Ala Cys Tyr Cys Ser Ala Thr Ser Arg Cys Asp Pro Gln Thr Gly 
        115                 120                 125             


Ala Cys Leu Cys His Ala Gly Trp Trp Gly Arg Ser Cys Asn Asn Gln 
    130                 135                 140                 


Cys Ala Cys Asn Ser Ser Pro Cys Glu Gln Gln Ser Gly Arg Cys Gln 
145                 150                 155                 160 


Cys Arg Glu Arg Thr Phe Gly Ala Arg Cys Asp Arg Tyr Cys Gln Cys 
                165                 170                 175     


Phe Arg Gly Arg Cys His Pro Val Asp Gly Thr Cys Ala Cys Glu Pro 
            180                 185                 190         


Gly Tyr Arg Gly Lys Tyr Cys Arg Glu Pro Cys Pro Ala Gly Phe Tyr 
        195                 200                 205             


Gly Leu Gly Cys Arg Arg Arg Cys Gly Gln Cys Lys Gly Gln Gln Pro 
    210                 215                 220                 


Cys Thr Val Ala Glu Gly Arg Cys Leu Thr Cys Glu Pro Gly Trp Asn 
225                 230                 235                 240 


Gly Thr Lys Cys Asp Gln Pro Cys Ala Thr Gly Phe Tyr Gly Glu Gly 
                245                 250                 255     


Cys Ser His Arg Cys Pro Pro Cys Arg Asp Gly His Ala Cys Asn His 
            260                 265                 270         


Val Thr Gly Lys Cys Thr Arg Cys Asn Ala Gly Trp Ile Gly Asp Arg 
        275                 280                 285             


Cys Glu Thr Lys Cys Ser Asn Gly Thr Tyr Gly Glu Asp Cys Ala Phe 
    290                 295                 300                 


Val Cys Ala Asp Cys Gly Ser Gly His Cys Asp Phe Gln Ser Gly Arg 
305                 310                 315                 320 


Cys Leu Cys Ser Pro Gly Val His Gly Pro His Cys Asn 
                325                 330             


<210>  10
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCARF2 ˱Ƥṹ򰱻УEGF like 4-6

<400>  10

Ser Ala Cys Tyr Cys Ser Ala Thr Ser Arg Cys Asp Pro Gln Thr Gly 
1               5                   10                  15      


Ala Cys Leu Cys His Ala Gly Trp Trp Gly Arg Ser Cys Asn Asn Gln 
            20                  25                  30          


Cys Ala Cys Asn Ser Ser Pro Cys Glu Gln Gln Ser Gly Arg Cys Gln 
        35                  40                  45              


Cys Arg Glu Arg Thr Phe Gly Ala Arg Cys Asp Arg Tyr Cys Gln Cys 
    50                  55                  60                  


Phe Arg Gly Arg Cys His Pro Val Asp Gly Thr Cys Ala Cys Glu Pro 
65                  70                  75                  80  


Gly Tyr Arg Gly Lys Tyr Cys Arg 
                85              


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siSCARF2 -1

<400>  11
gcgagaccaa guguagcaa                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siSCARF2 -2

<400>  12
gugacaggcc aguguacuu                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siSCARF2 -3

<400>  13
ccugccaccu agaaaccaa                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siSCARF2 -4

<400>  14
uccuucuccu cguuugaca                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siSCARF2 -5

<400>  15
gacugcaagg agcugugua                                                    19


