                         SEQUENCE LISTING

<110>  Immatics Biotechnologies GmbH
 
<120>  Antigen binding proteins specifically binding PRAME

<130>  P197PC00/1017-3 PCT

<150>  DE 10 2019 100963.4
<151>  2019-01-15

<150>  US 62/792,789
<151>  2019-01-15

<160>  182   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)

<400>  1

Asp Arg Gly Ser Gln Xaa 
1               5       


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  wherein Xaa is any amino acid, preferably S or Q, more preferably
       Q

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid, preferably T, E, D or A, more preferably 
       E,

<400>  2

Ile Tyr Xaa Xaa Gly Asp 
1               5       


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  wherein Xaa is any amino acid, preferably, X4 is  S, N, D, P, T, 
       or E, more preferably P.

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  wherein Xaa is any amino acid, preferably, Xaa is L, I, V, Q, N, 
       P, S, A, G, T, D, K, R, F, more preferably V.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  wherein Xaa is any amino acid, preferably, Xaa is E, A, V, R, N, 
       G, Y, I, D, H, L, P, S, Q, more preferably V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  wherein Xaa is any amino acid, preferably, Xaa is is S, I, Q, A, 
       R, L, P, Y, K, M, more preferably Q

<400>  3

Cys Ala Ala Val Ile Xaa Asn Xaa Xaa Gly Gly Xaa Leu Thr Phe 
1               5                   10                  15  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  wherein Xaa is any amino acid, preferably S or P, more preferably
       P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  wherein Xaa is any amino acid, preferably S or A, more preferably
       A

<400>  4

Xaa Gly His Arg Xaa 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  wherein Xaa is any amino acid, preferably Xaa is V, I, F or E, 
       more preferably I or V, more preferably V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  wherein Xaa is any amino acid, preferably Xaa is H, D, or S, more
       preferably D or H, more preferably H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  wherein Xaa is any amino acid, preferably G, R or E, more 
       preferably G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  wherein Xaa is any amino acid, preferably Q, R, A, F, V, Q, E, L,
       Y or T, more preferably E or A, more preferably E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  wherein Xaa is any amino acid, preferably is E, A or Q, more 
       preferably E or Q, more preferably E

<400>  5

Tyr Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  wherein Xaa is any amino acid preferably V

<400>  6

Cys Ala Ser Ser Pro Trp Asp Ser Pro Asn Xaa Gln Tyr Phe 
1               5                   10                  


<210>  7
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length PRAME protein, P78395

<400>  7

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRAME-004 peptide

<400>  8

Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa2 (i.e. R16P1C10)

<400>  9

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3 (i.e R16P1C10)

<400>  10

Cys Ala Ala Val Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe 
1               5                   10                  15  


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa1 (i.e HiAff1)

<400>  11

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb1 (i.e R16P1C10)

<400>  12

Ser Gly His Arg Ser 
1               5   


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb3 (i.e R16P1C10)

<400>  13

Cys Ala Ser Ser Pro Trp Asp Ser Pro Asn Glu Gln Tyr Phe 
1               5                   10                  


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb2 (i.e R16P1C10)

<400>  14

Tyr Phe Ser Glu Thr Gln 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb2 second consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  wherein Xaa is any amino acid, preferably Q, R, A, F, V, Q, E, L,
       Y or T, preferably E

<400>  15

Tyr Val His Gly Xaa Glu 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa1 variant 1

<400>  16

Asp Arg Gly Ser Gln Leu 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa2 variant 2

<400>  17

Ile Tyr Gln Glu Gly Asp 
1               5       


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  18

Cys Ala Ala Val Ile Asn Asn Pro Ser Gly Gly Met Leu Thr Phe 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  19

Cys Ala Ala Val Ile Asp Asn Ser Asn Gly Gly Ile Leu Thr Phe 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  20

Cys Ala Ala Val Ile Asp Asn Pro Ser Gly Gly Ile Leu Thr Phe 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  21

Cys Ala Ala Val Ile Asp Asn Asp Gln Gly Gly Ile Leu Thr Phe 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  22

Cys Ala Ala Val Ile Pro Asn Pro Pro Gly Gly Lys Leu Thr Phe 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  23

Cys Ala Ala Val Ile Pro Asn Pro Gly Gly Gly Ala Leu Thr Phe 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  24

Cys Ala Ala Val Ile Pro Asn Ser Ala Gly Gly Arg Leu Thr Phe 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  25

Cys Ala Ala Val Ile Pro Asn Leu Glu Gly Gly Ser Leu Thr Phe 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  26

Cys Ala Ala Val Ile Pro Asn Arg Leu Gly Gly Tyr Leu Thr Phe 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  27

Cys Ala Ala Val Ile Pro Asn Thr Asp Gly Gly Arg Leu Thr Phe 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  28

Cys Ala Ala Val Ile Pro Asn Gln Arg Gly Gly Ala Leu Thr Phe 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  29

Cys Ala Ala Val Ile Pro Asn Val Val Gly Gly Ile Leu Thr Phe 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  30

Cys Ala Ala Val Ile Thr Asn Ile Ala Gly Gly Ser Leu Thr Phe 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  31

Cys Ala Ala Val Ile Pro Asn Asn Asp Gly Gly Tyr Leu Thr Phe 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  32

Cys Ala Ala Val Ile Pro Asn Gly Arg Gly Gly Leu Leu Thr Phe 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  33

Cys Ala Ala Val Ile Pro Asn Thr His Gly Gly Pro Leu Thr Phe 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  34

Cys Ala Ala Val Ile Pro Asn Asp Val Gly Gly Ser Leu Thr Phe 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  35

Cys Ala Ala Val Ile Glu Asn Lys Pro Gly Gly Pro Leu Thr Phe 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  36

Cys Ala Ala Val Ile Asp Asn Pro Val Gly Gly Pro Leu Thr Phe 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  37

Cys Ala Ala Val Ile Pro Asn Asn Asn Gly Gly Ala Leu Thr Phe 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  38

Cys Ala Ala Val Ile Pro Asn Asp Gln Gly Gly Ile Leu Thr Phe 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  39

Cys Ala Ala Val Ile Pro Asn Val Val Gly Gly Gln Leu Thr Phe 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  40

Cys Ala Ala Val Ile Pro Asn Ser Tyr Gly Gly Leu Leu Thr Phe 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  41

Cys Ala Ala Val Ile Pro Asn Asp Asp Gly Gly Leu Leu Thr Phe 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  42

Cys Ala Ala Val Ile Pro Asn Ala Ala Gly Gly Leu Leu Thr Phe 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  43

Cys Ala Ala Val Ile Pro Asn Thr Ile Gly Gly Leu Leu Thr Phe 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3

<400>  44

Cys Ala Ala Val Ile Pro Asn Thr Arg Gly Gly Leu Leu Thr Phe 
1               5                   10                  15  


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb1

<400>  45

Pro Gly His Arg Ala 
1               5   


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb2 (i.e HiAff1)

<400>  46

Tyr Val His Gly Glu Glu 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRB2 (I.E IMPROVED)

<400>  47

Tyr Val His Gly Ala Glu 
1               5       


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb3 (i.e HiAff1)

<400>  48

Cys Ala Ser Ser Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe 
1               5                   10                  


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRb1 (i.e Improved)

<400>  49

Pro Gly His Arg Ser 
1               5   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFIT1-001

<400>  50

Val Leu Leu His His Gln Ile Gly Leu 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT17-003

<400>  51

Phe Met Asn Pro His Leu Ile Ser Val 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FADS2-001

<400>  52

Leu Leu Leu Ala His Ile Ile Ala Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTBP1-001

<400>  53

Ala Leu Met Tyr His Thr Ile Thr Leu 
1               5                   


<210>  54
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-a

<400>  54

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser 
            20                  25      


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2-a

<400>  55

Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
1               5                   10                  15      


Ser 
    


<210>  56
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3-a

<400>  56

Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
1               5                   10                  15      


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
            20                  25                  30          


Leu 
    


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4-a

<400>  57

Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn 
1               5                   10                  


<210>  58
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-b

<400>  58

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile 
            20                  25      


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2-b

<400>  59

Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe 
1               5                   10                  15      


Glu 
    


<210>  60
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3-b

<400>  60

Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly Arg Gln Phe Ser 
1               5                   10                  15      


Asn Ser Ser Ser Glu Met Asn Ile Ser Asn Leu Glu Leu Gly Asp Ser 
            20                  25                  30          


Ala Leu Tyr Leu 
        35      


<210>  61
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3-b

<400>  61

Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly Arg Gln Phe Ser 
1               5                   10                  15      


Asn Phe Ser Ser Glu Met Asn Ile Ser Asn Leu Glu Leu Gly Asp Ser 
            20                  25                  30          


Ala Leu Tyr Leu 
        35      


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4-b

<400>  62

Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn 
1               5                   10                  


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V3 of Fc-containing HiAff1 TCR/mAb diabody

<400>  63

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1 in the molecule Fc-containing HiAff1 TCR/mAb diabody

<400>  64

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the humanized UCHT1

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc1 with "Knob" mutation

<400>  66

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  67
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vbeta variable domain (B2)

<400>  67

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser Asn 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp 
                85                  90                  95      


Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Thr Glu Asp Leu Lys Asn 
        115             


<210>  68
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc2 with "Hole mutation"

<400>  68

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  69

Thr Val Ala Ala Pro 
1               5   


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Gly Gly Gly Ser 
1               


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Gly Gly Gly Gly Ser 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Thr Val Leu Arg Thr 
1               5   


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  73

Thr Val Ser Ser Ala Ser 
1               5       


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  74

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  75

Gly Gly Gly Gly Ser Ala Ala Ala 
1               5               


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  76

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  77
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            20                  25          


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  78

Thr Val Leu Ser Ser Ala Ser 
1               5           


<210>  79
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  native Fc  (IGHG1*01)

<400>  79

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  80
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge-CH1

<400>  80

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Pro Val Ala Gly 
        115                 


<210>  81
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  first polypeptide of the scTCR-Fab construct

<400>  81

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu 
                245                 250                 255     


Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln 
            260                 265                 270         


Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile 
        275                 280                 285             


Met Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala 
    290                 295                 300                 


Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser 
305                 310                 315                 320 


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn 
                325                 330                 335     


Asp Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile 
            340                 345                 350         


Ile Pro Asn Ile Gln Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Ser Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg 
385                 390                 395                 400 


Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala 
                405                 410                 415     


Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe 
            420                 425                 430         


Glu Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg 
        435                 440                 445             


Phe Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser 
    450                 455                 460                 


Asn Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro 
465                 470                 475                 480 


Trp Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
                485                 490                 495     


Val Thr Glu Asp Leu Lys Asn 
            500             


<210>  82
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  second polypeptide of the scTCR-Fab

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  83
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vbeta-domain (designated B2)

<400>  83

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser Asn 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp 
                85                  90                  95      


Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Thr Glu Asp Leu Lys Asn 
        115             


<210>  84
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-Myc tag

<400>  84

Ala Ala Ala Gly Gly Ser Gly Gly Glu Gln Lys Leu Ile Ser Glu Glu 
1               5                   10                  15      


Asp Leu 
        


<210>  85
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#1

<400>  85

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Pro 
                85                  90                  95      


Gly Gly Gly Ala Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  86
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#2

<400>  86

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Ser 
                85                  90                  95      


Ala Gly Gly Arg Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  87
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#3

<400>  87

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Leu 
                85                  90                  95      


Glu Gly Gly Ser Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  88
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#4

<400>  88

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Arg 
                85                  90                  95      


Leu Gly Gly Tyr Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  89
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#5

<400>  89

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Thr 
                85                  90                  95      


Asp Gly Gly Arg Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  90
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#6

<400>  90

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Gln 
                85                  90                  95      


Arg Gly Gly Ala Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  91
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#7

<400>  91

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Val 
                85                  90                  95      


Val Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  92
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#9

<400>  92

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Thr Asn Ile 
                85                  90                  95      


Ala Gly Gly Ser Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  93
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#10

<400>  93

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Gln Gly Gly Tyr Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  94
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#11

<400>  94

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Gly 
                85                  90                  95      


Arg Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  95
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#12

<400>  95

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Thr 
                85                  90                  95      


His Gly Gly Pro Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  96
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#13

<400>  96

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Val Gly Gly Ser Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  97
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#14

<400>  97

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Glu Asn Lys 
                85                  90                  95      


Pro Gly Gly Pro Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  98
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#15

<400>  98

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Pro 
                85                  90                  95      


Val Gly Gly Pro Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  99
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#16

<400>  99

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asn 
                85                  90                  95      


Ile Gly Gly Ala Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  100
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#17

<400>  100

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  101
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#18

<400>  101

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  102
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#19

<400>  102

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Ser 
                85                  90                  95      


Ala Gly Gly Arg Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#20

<400>  103

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Arg 
                85                  90                  95      


Leu Gly Gly Tyr Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  104
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#22

<400>  104

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Thr 
                85                  90                  95      


His Gly Gly Pro Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  105
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#23

<400>  105

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Val 
                85                  90                  95      


Val Gly Gly Gln Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  106
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#24

<400>  106

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Ser 
                85                  90                  95      


Tyr Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#26

<400>  107

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Ala 
                85                  90                  95      


Ala Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  108
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#27

<400>  108

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Thr 
                85                  90                  95      


Ile Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  109
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#29

<400>  109

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Asp Gly Gly Arg Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  110
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#30

<400>  110

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Thr 
                85                  90                  95      


Arg Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  111
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1_38

<400>  111

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  112
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vbeta B2_S85F

<400>  112

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Phe Ser Ser Glu Met Asn Ile Ser Asn 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp 
                85                  90                  95      


Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Thr Glu Asp Leu Lys Asn 
        115             


<210>  113
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#24

<400>  113

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Ser 
                85                  90                  95      


Tyr Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  114
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#18

<400>  114

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  115
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#23

<400>  115

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Val 
                85                  90                  95      


Val Gly Gly Gln Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  116
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1#20

<400>  116

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Arg 
                85                  90                  95      


Leu Gly Gly Tyr Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  117
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  117

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  118
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha A_HiAff1_38

<400>  118

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  119
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  first polypeptide of Fc-containing HiAff1 bispecific 
       TCR/mAb(anti-CD3) diabody

<400>  119

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr 
                165                 170                 175     


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
        195                 200                 205             


Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp Thr Phe Gly 
    210                 215                 220                 


Gln Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460     


<210>  120
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  second polypeptide of Fc-containing HiAff1 bispecific 
       TCR/mAb(anti-CD3) diabody

<400>  120

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr 
    130                 135                 140                 


Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg 
145                 150                 155                 160 


Ala Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu 
                165                 170                 175     


Phe Glu Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly 
            180                 185                 190         


Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile 
        195                 200                 205             


Ser Asn Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser 
    210                 215                 220                 


Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Thr Glu Asp Leu Lys Asn Glu Pro Lys Ser Ser Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475         


<210>  121
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-CD3

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  122
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-CD3

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  123
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL

<400>  123

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  124
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha beta fusion

<400>  124

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
    130                 135                 140                 


Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
145                 150                 155                 160 


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val 
                165                 170                 175     


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
            180                 185                 190         


Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
        195                 200                 205             


Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser Asn 
    210                 215                 220                 


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp 
225                 230                 235                 240 


Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
                245                 250                 255     


Thr Glu Asp Leu Lys Asn 
            260         


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide ATP1A1-001

<400>  125

Phe Leu Pro Ile His Leu Leu Gly Leu 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide NADK-002

<400>  126

Tyr Leu Asp Gly His Leu Ile Thr Thr 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide ITSN1-001

<400>  127

Ile Leu Ala Met His Leu Ile Asp Val 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide SMA-003

<400>  128

Ile Val Ile Asn His Val Ile Ser Val 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide SF3B3-005

<400>  129

Thr Leu Val Tyr His Val Val Gly Val 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide SF3B3-005

<400>  130

Thr Leu Val Tyr His Val Val Gly Val 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide NCAM2-001

<400>  131

Phe Val Gln Pro His Ile Ile Gln Leu 
1               5                   


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide KNT-001

<400>  132

Tyr Met Leu Glu His Val Ile Thr Leu 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide EHD4-001

<400>  133

Ala Leu Ala Lys His Leu Ile Lys Ile 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide EHD-001

<400>  134

Ala Leu Ala Asn His Leu Ile Lys Val 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide MCMB-002

<400>  135

Tyr Leu Ile Leu His Leu Ile Ser Thr 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide HSPA5-001

<400>  136

Arg Val Met Glu His Phe Ile Lys Leu 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CEBPZ-002

<400>  137

Lys Leu Tyr Gln His Glu Ile Asn Leu 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF12-001

<400>  138

Ser Phe Tyr Glu His Ile Ile Thr Val 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide EHD2-002

<400>  139

Ala Leu Ala Ser His Leu Ile Glu Ala 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide KIAA1324-001

<400>  140

Ser Leu Ala Asp Arg Leu Ile Gly Val 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide MYO1A-001

<400>  141

Leu Val Ser Glu His Val Ile Glu Leu 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide SERPINA6-001

<400>  142

Ser Leu Tyr Lys His Leu Val Ala Leu 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide SMARCD1-001

<400>  143

Ile Ile Ile Asn His Val Ile Ser Val 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide TSC1-001

<400>  144

Ser Leu Leu Gly His Val Ile Arg Leu 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide UGT-005

<400>  145

Ser Leu Ile Glu His Met Ile Met Leu 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide VAV1-001

<400>  146

Asn Leu Leu Pro His Ala Ile Asn Leu 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide WDFY3-004

<400>  147

Ser Leu Phe Glu His Phe Ile Glu Leu 
1               5                   


<210>  148
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16P1C10 alpha variable domain

<400>  148

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Val Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Thr Ile Ile Pro 
    130                 


<210>  149
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16P1C10 beta variable domain

<400>  149

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Trp Asp Ser Pro Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr 
    130         


<210>  150
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTCR CDR6

<400>  150

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val 
    130                 135                 140                 


Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln Val Thr 
145                 150                 155                 160 


Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Val His Gly 
            180                 185                 190         


Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly Arg Gln 
        195                 200                 205             


Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser Asn Leu Glu Leu Gly 
    210                 215                 220                 


Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp Asp Ser Pro Asn 
225                 230                 235                 240 


Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu 
                245                 250                 255     


Lys Asn 
        


<210>  151
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  151

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  152
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aga2p yeast mating protein together with its leader sequence

<400>  152

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr 
            20                  25                  30          


Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn 
        35                  40                  45              


Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe 
    50                  55                  60                  


Val Ser Asn Cys Gly Ser His Pro Ser Thr Thr Ser Lys Gly Ser Pro 
65                  70                  75                  80  


Ile Asn Thr Gln Tyr Val Phe 
                85          


<210>  153
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader peptide- Aga2p-FLAG -L- scTCR CDR6

<400>  153

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr 
            20                  25                  30          


Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn 
        35                  40                  45              


Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe 
    50                  55                  60                  


Val Ser Asn Cys Gly Ser His Pro Ser Thr Thr Ser Lys Gly Ser Pro 
65                  70                  75                  80  


Ile Asn Thr Gln Tyr Val Phe Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
                85                  90                  95      


Asp Asp Asp Lys Gly Gly Gly Ala Ser Gln Lys Glu Val Glu Gln Asn 
            100                 105                 110         


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
        115                 120                 125             


Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr 
    130                 135                 140                 


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
145                 150                 155                 160 


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
                165                 170                 175     


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
            180                 185                 190         


Leu Cys Ala Ala Val Ile Asp Asn Asp Gln Gly Gly Ile Leu Thr Phe 
        195                 200                 205             


Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Val Thr Gln Thr Pro Arg Tyr Leu 
                245                 250                 255     


Ile Lys Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro 
            260                 265                 270         


Gly His Arg Ala Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu 
        275                 280                 285             


Gln Phe Leu Phe Glu Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn 
    290                 295                 300                 


Phe Pro Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu 
305                 310                 315                 320 


Met Asn Ile Ser Asn Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys 
                325                 330                 335     


Ala Ser Ser Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly 
            340                 345                 350         


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Ala Ala Ala Gly Gly 
        355                 360                 365             


Ser Gly Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    370                 375                 380     


<210>  154
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag plus linkers

<400>  154

Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly 
1               5                   10                  15      


Ala Ser 
        


<210>  155
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge region of IgG1

<400>  155

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly 
            20      


<210>  156
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge regioin of IgG2

<400>  156

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro 
            


<210>  157
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge IgG3

<400>  157

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly 
    50              


<210>  158
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge IgG4

<400>  158

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly 
        


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  159

Gly Gly Gly Gly Ser Gly Thr 
1               5           


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  160

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  161
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  161

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  162
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  162

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr 
1               5                   10          


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  163

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Thr 
    


<210>  164
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  164

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Thr 
            20          


<210>  165
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  165

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  166
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  166

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr 
            20                  25          


<210>  167
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  167

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25  


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  168

Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Gly Lys 
1               5                   10                  15      


Ser 
    


<210>  169
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  169

Gly Gly Gln Gly Ser Gly Gly Thr Gly Ser Gly Gly Gln Gly Ser Gly 
1               5                   10                  15      


Gly Thr Gly Ser Gly Gly Gln Gly Ser 
            20                  25  


<210>  170
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  170

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  171
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of UCHT1(17)

<400>  171

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  172
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of UCHT1(23)

<400>  172

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  173
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of BMA (10)

<400>  173

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  174
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of BMA (10)

<400>  174

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  175
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of BMA (36)

<400>  175

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  176
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of BMA (36)

<400>  176

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  177
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of UCHT1 (17opt)

<400>  177

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  178
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of UCHT1 (21)

<400>  178

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  179
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRa3 of Valpha A_HiAff1#29

<400>  179

Cys Ala Ala Val Ile Pro Asn Asp Asp Gly Gly Arg Leu Thr Phe 
1               5                   10                  15  


<210>  180
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Valpha of  A_HiAff1#29B

<400>  180

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Leu 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Pro Asn Asp 
                85                  90                  95      


Asp Gly Gly Leu Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  181
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3a of Valpha A_HiAff1#10

<400>  181

Cys Ala Ala Val Ile Pro Asn Asp Gln Gly Gly Tyr Leu Thr Phe 
1               5                   10                  15  


<210>  182
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3a of Valpha A_HiAff1#16

<400>  182

Cys Ala Ala Val Ile Pro Asn Asn Ile Gly Gly Ala Leu Thr Phe 
1               5                   10                  15  


