               SEQUENCE LISTING

<110> INSERM (Institut National de la Santé et de la Recherche Médicale)
      Université de la Réunion Saint Denis
      Centre National de la Recherche Scientifique (CNRS)
      Institut de Recherche pour le Développement (IRD)

<120> ANTIGENIC REACTIVITY OF A PEPTIDE MIMICKING THE GLYCAN LOOP OF FLAVIVIRUSES ENVELOPE PROTEIN

<130> PR89013

<150> EP20305021
<151> 2020-01-14

<160> 27

<170> BiSSAP 1.3.6

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> [N-ter]-Valine*-Asparagine*-Aspartic Acid*-Xaa2-Glycine*-[C-ter];
      with Xaa2 being any amino acid

<220> 
<221> VARIANT
<222> 4
<223> Xaa2 being any amino acid

<400> 1
Val Asn Asp Xaa Gly 
1               5   

<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> [N-ter]-Valine*-Asparagine*-Aspartic
      Acid*-Xaa2-Glycine*-Xaa3*-[C-ter]; with Xaa2 and Xaa3 being any
      amino acid

<220> 
<221> VARIANT
<222> 4
<223> Xaa2 being any amino acid

<220> 
<221> VARIANT
<222> 6
<223> Xaa3 being any amino acid

<400> 2
Val Asn Asp Xaa Gly Xaa 
1               5       

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> [N-ter]-Xaa1-Valine*-Asparagine*-Aspartic
      Acid*-Xaa2-Glycine*-Xaa3-[C-ter]; with Xaa1, Xaa2 and Xaa3 being
      any amino acid

<220> 
<221> VARIANT
<222> 1
<223> Xaa1 being any amino acid

<220> 
<221> VARIANT
<222> 5
<223> Xaa2 being any amino acid

<220> 
<221> VARIANT
<222> 7
<223> Xaa3 being any amino acid

<400> 3
Xaa Val Asn Asp Xaa Gly Xaa 
1               5           

<210> 4
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID4

<400> 4
Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly Tyr Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID5

<400> 5
Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID6

<400> 6
Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly His Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 7
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID7

<400> 7
Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly Tyr Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID8

<400> 8
Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Thr Gly Tyr Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID9

<400> 9
Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile Gly His Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID10

<400> 10
Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Thr Gly His Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 11
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID11

<400> 11
Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly Tyr Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

<210> 12
<211> 130
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID12

<400> 12
Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      
Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          
Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              
Thr Val Ser Asn Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val 
    50                  55                  60                  
His Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly Tyr Glu 
65                  70                  75                  80  
Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg 
                85                  90                  95      
Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu 
            100                 105                 110         
Pro Arg Ala Lys Gly Arg Leu Ser Ser Gly His Leu Cys Arg Leu Lys 
        115                 120                 125             
Met Asp 
    130 

<210> 13
<211> 3423
<212> PRT
<213> Zika virus


<220> 
<223> ZIKV MR766 E polyprotein (from Genbank access n°LC002520)

<400> 13
Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      
Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          
Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              
Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  
Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  
Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      
Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         
Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             
Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 
Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 
Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     
Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         
Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             
Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 
Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 
Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     
Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         
Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             
Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 
Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 
Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     
Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         
Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             
Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 
Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 
Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     
Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         
Val His Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile Gly Tyr 
        435                 440                 445             
Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 
    450                 455                 460                 
Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 
Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     
Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         
Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             
Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 
Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 
Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser 
                565                 570                 575     
Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         
Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 
        595                 600                 605             
Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 
Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 
Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     
Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         
Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 
        675                 680                 685             
His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 
Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 
Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     
Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         
Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 
        755                 760                 765             
Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 
Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 
Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr 
                805                 810                 815     
Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         
Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 
        835                 840                 845             
Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 
    850                 855                 860                 
Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 
Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     
Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         
Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             
Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp 
    930                 935                 940                 
Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 
Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     
Val Ile Gly Thr Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu 
            980                 985                 990         
Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp Thr Trp Arg Leu Lys Arg 
        995                 1000                1005            
Ala His Leu Ile Glu Met Lys Thr Cys Glu Trp Pro Lys Ser His Thr 
    1010                1015                1020                
Leu Trp Thr Asp Gly Val Glu Glu Ser Asp Leu Ile Ile Pro Lys Ser 
1025                1030                1035                1040
Leu Ala Gly Pro Leu Ser His His Asn Thr Arg Glu Gly Tyr Arg Thr 
                1045                1050                1055    
Gln Val Lys Gly Pro Trp His Ser Glu Glu Leu Glu Ile Arg Phe Glu 
            1060                1065                1070        
Glu Cys Pro Gly Thr Lys Val Tyr Val Glu Glu Thr Cys Gly Thr Arg 
        1075                1080                1085            
Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser Gly Arg Val Ile Glu Glu 
    1090                1095                1100                
Trp Cys Cys Arg Glu Cys Thr Met Pro Pro Leu Ser Phe Arg Ala Lys 
1105                1110                1115                1120
Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Arg Lys Glu Pro Glu 
                1125                1130                1135    
Ser Asn Leu Val Arg Ser Met Val Thr Ala Gly Ser Thr Asp His Met 
            1140                1145                1150        
Asp His Phe Ser Leu Gly Val Leu Val Ile Leu Leu Met Val Gln Glu 
        1155                1160                1165            
Gly Leu Lys Lys Arg Met Thr Thr Lys Ile Ile Met Ser Thr Ser Met 
    1170                1175                1180                
Ala Val Leu Val Val Met Ile Leu Gly Gly Phe Ser Met Ser Asp Leu 
1185                1190                1195                1200
Ala Lys Leu Val Ile Leu Met Gly Ala Thr Phe Ala Glu Met Asn Thr 
                1205                1210                1215    
Gly Gly Asp Val Ala His Leu Ala Leu Val Ala Ala Phe Lys Val Arg 
            1220                1225                1230        
Pro Ala Leu Leu Val Ser Phe Ile Phe Arg Ala Asn Trp Thr Pro Arg 
        1235                1240                1245            
Glu Ser Met Leu Leu Ala Leu Ala Ser Cys Leu Leu Gln Thr Ala Ile 
    1250                1255                1260                
Ser Ala Leu Glu Gly Asp Leu Met Val Leu Ile Asn Gly Phe Ala Leu 
1265                1270                1275                1280
Ala Trp Leu Ala Ile Arg Ala Met Ala Val Pro Arg Thr Asp Asn Ile 
                1285                1290                1295    
Ala Leu Pro Ile Leu Ala Ala Leu Thr Pro Leu Ala Arg Gly Thr Leu 
            1300                1305                1310        
Leu Val Ala Trp Arg Ala Gly Leu Ala Thr Cys Gly Gly Ile Met Leu 
        1315                1320                1325            
Leu Ser Leu Lys Gly Lys Gly Ser Val Lys Lys Asn Leu Pro Phe Val 
    1330                1335                1340                
Met Ala Leu Gly Leu Thr Ala Val Arg Val Val Asp Pro Ile Asn Val 
1345                1350                1355                1360
Val Gly Leu Leu Leu Leu Thr Arg Ser Gly Lys Arg Ser Trp Pro Pro 
                1365                1370                1375    
Ser Glu Val Leu Thr Ala Val Gly Leu Ile Cys Ala Leu Ala Gly Gly 
            1380                1385                1390        
Phe Ala Lys Ala Asp Ile Glu Met Ala Gly Pro Met Ala Ala Val Gly 
        1395                1400                1405            
Leu Leu Ile Val Ser Tyr Val Val Ser Gly Lys Ser Val Asp Met Tyr 
    1410                1415                1420                
Ile Glu Arg Ala Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Val Thr 
1425                1430                1435                1440
Gly Asn Ser Pro Arg Leu Asp Val Ala Leu Asp Glu Ser Gly Asp Phe 
                1445                1450                1455    
Ser Leu Val Glu Glu Asp Gly Pro Pro Met Arg Glu Ile Ile Leu Lys 
            1460                1465                1470        
Val Val Leu Met Ala Ile Cys Gly Met Asn Pro Ile Ala Ile Pro Phe 
        1475                1480                1485            
Ala Ala Gly Ala Trp Tyr Val Tyr Val Lys Thr Gly Lys Arg Ser Gly 
    1490                1495                1500                
Ala Leu Trp Asp Val Pro Ala Pro Lys Glu Val Lys Lys Gly Glu Thr 
1505                1510                1515                1520
Thr Asp Gly Val Tyr Arg Val Met Thr Arg Arg Leu Leu Gly Ser Thr 
                1525                1530                1535    
Gln Val Gly Val Gly Val Met Gln Glu Gly Val Phe His Thr Met Trp 
            1540                1545                1550        
His Val Thr Lys Gly Ala Ala Leu Arg Ser Gly Glu Gly Arg Leu Asp 
        1555                1560                1565            
Pro Tyr Trp Gly Asp Val Lys Gln Asp Leu Val Ser Tyr Cys Gly Pro 
    1570                1575                1580                
Trp Lys Leu Asp Ala Ala Trp Asp Gly Leu Ser Glu Val Gln Leu Leu 
1585                1590                1595                1600
Ala Val Pro Pro Gly Glu Arg Ala Arg Asn Ile Gln Thr Leu Pro Gly 
                1605                1610                1615    
Ile Phe Lys Thr Lys Asp Gly Asp Ile Gly Ala Val Ala Leu Asp Tyr 
            1620                1625                1630        
Pro Ala Gly Thr Ser Gly Ser Pro Ile Leu Asp Lys Cys Gly Arg Val 
        1635                1640                1645            
Ile Gly Leu Tyr Gly Asn Gly Val Val Ile Lys Asn Gly Ser Tyr Val 
    1650                1655                1660                
Ser Ala Ile Thr Gln Gly Lys Arg Glu Glu Glu Thr Pro Val Glu Cys 
1665                1670                1675                1680
Phe Glu Pro Ser Met Leu Lys Lys Lys Gln Leu Thr Val Leu Asp Leu 
                1685                1690                1695    
His Pro Gly Ala Gly Lys Thr Arg Arg Val Leu Pro Glu Ile Val Arg 
            1700                1705                1710        
Glu Ala Ile Lys Lys Arg Leu Arg Thr Val Ile Leu Ala Pro Thr Arg 
        1715                1720                1725            
Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu Pro Val Arg 
    1730                1735                1740                
Tyr Met Thr Thr Ala Val Asn Val Thr His Ser Gly Thr Glu Ile Val 
1745                1750                1755                1760
Asp Leu Met Cys His Ala Thr Phe Thr Ser Arg Leu Leu Gln Pro Ile 
                1765                1770                1775    
Arg Val Pro Asn Tyr Asn Leu Tyr Ile Met Asp Glu Ala His Phe Thr 
            1780                1785                1790        
Asp Pro Ser Ser Ile Ala Ala Arg Gly Tyr Ile Ser Thr Arg Val Glu 
        1795                1800                1805            
Met Gly Glu Ala Ala Ala Ile Phe Met Thr Ala Thr Pro Pro Gly Thr 
    1810                1815                1820                
Arg Asp Ala Phe Pro Asp Ser Asn Ser Pro Ile Met Asp Thr Glu Val 
1825                1830                1835                1840
Glu Val Pro Glu Arg Ala Trp Ser Ser Gly Phe Asp Trp Val Thr Asp 
                1845                1850                1855    
His Ser Gly Lys Thr Val Trp Phe Val Pro Ser Val Arg Asn Gly Asn 
            1860                1865                1870        
Glu Ile Ala Ala Cys Leu Thr Lys Ala Gly Lys Arg Val Ile Gln Leu 
        1875                1880                1885            
Ser Arg Lys Thr Phe Glu Thr Glu Phe Gln Lys Thr Lys Asn Gln Glu 
    1890                1895                1900                
Trp Asp Phe Val Ile Thr Thr Asp Ile Ser Glu Met Gly Ala Asn Phe 
1905                1910                1915                1920
Lys Ala Asp Arg Val Ile Asp Ser Arg Arg Cys Leu Lys Pro Val Ile 
                1925                1930                1935    
Leu Asp Gly Glu Arg Val Ile Leu Ala Gly Pro Met Pro Val Thr His 
            1940                1945                1950        
Ala Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg Asn Pro Asn Lys 
        1955                1960                1965            
Pro Gly Asp Glu Tyr Met Tyr Gly Gly Gly Cys Ala Glu Thr Asp Glu 
    1970                1975                1980                
Gly His Ala His Trp Leu Glu Ala Arg Met Leu Leu Asp Asn Ile Tyr 
1985                1990                1995                2000
Leu Gln Asp Gly Leu Ile Ala Ser Leu Tyr Arg Pro Glu Ala Asp Lys 
                2005                2010                2015    
Val Ala Ala Ile Glu Gly Glu Phe Lys Leu Arg Thr Glu Gln Arg Lys 
            2020                2025                2030        
Thr Phe Val Glu Leu Met Lys Arg Gly Asp Leu Pro Val Trp Leu Ala 
        2035                2040                2045            
Tyr Gln Val Ala Ser Ala Gly Ile Thr Tyr Thr Asp Arg Arg Trp Cys 
    2050                2055                2060                
Phe Asp Gly Thr Thr Asn Asn Thr Ile Met Glu Asp Ser Val Pro Ala 
2065                2070                2075                2080
Glu Val Trp Thr Lys Tyr Gly Glu Lys Arg Val Leu Lys Pro Arg Trp 
                2085                2090                2095    
Met Asp Ala Arg Val Cys Ser Asp His Ala Ala Leu Lys Ser Phe Lys 
            2100                2105                2110        
Glu Phe Ala Ala Gly Lys Arg Gly Ala Ala Leu Gly Val Met Glu Ala 
        2115                2120                2125            
Leu Gly Thr Leu Pro Gly His Met Thr Glu Arg Phe Gln Glu Ala Ile 
    2130                2135                2140                
Asp Asn Leu Ala Val Leu Met Arg Ala Glu Thr Gly Ser Arg Pro Tyr 
2145                2150                2155                2160
Lys Ala Ala Ala Ala Gln Leu Pro Glu Thr Leu Glu Thr Ile Met Leu 
                2165                2170                2175    
Leu Gly Leu Leu Gly Thr Val Ser Leu Gly Ile Phe Phe Val Leu Met 
            2180                2185                2190        
Arg Asn Lys Gly Ile Gly Lys Met Gly Phe Gly Met Val Thr Leu Gly 
        2195                2200                2205            
Ala Ser Ala Trp Leu Met Trp Leu Ser Glu Ile Glu Pro Ala Arg Ile 
    2210                2215                2220                
Ala Cys Val Leu Ile Val Val Phe Leu Leu Leu Val Val Leu Ile Pro 
2225                2230                2235                2240
Glu Pro Glu Lys Gln Arg Ser Pro Gln Asp Asn Gln Met Ala Ile Ile 
                2245                2250                2255    
Ile Met Val Ala Val Gly Leu Leu Gly Leu Ile Thr Ala Asn Glu Leu 
            2260                2265                2270        
Gly Trp Leu Glu Arg Thr Lys Asn Asp Ile Ala His Leu Met Gly Arg 
        2275                2280                2285            
Arg Glu Glu Gly Ala Thr Met Gly Phe Ser Met Asp Ile Asp Leu Arg 
    2290                2295                2300                
Pro Ala Ser Ala Trp Ala Ile Tyr Ala Ala Leu Thr Thr Leu Ile Thr 
2305                2310                2315                2320
Pro Ala Val Gln His Ala Val Thr Thr Ser Tyr Asn Asn Tyr Ser Leu 
                2325                2330                2335    
Met Ala Met Ala Thr Gln Ala Gly Val Leu Phe Gly Met Gly Lys Gly 
            2340                2345                2350        
Met Pro Phe Tyr Ala Trp Asp Leu Gly Val Pro Leu Leu Met Met Gly 
        2355                2360                2365            
Cys Tyr Ser Gln Leu Thr Pro Leu Thr Leu Ile Val Ala Ile Ile Leu 
    2370                2375                2380                
Leu Val Ala His Tyr Met Tyr Leu Ile Pro Gly Leu Gln Ala Ala Ala 
2385                2390                2395                2400
Ala Arg Ala Ala Gln Lys Arg Thr Ala Ala Gly Ile Met Lys Asn Pro 
                2405                2410                2415    
Val Val Asp Gly Ile Val Val Thr Asp Ile Asp Thr Met Thr Ile Asp 
            2420                2425                2430        
Pro Gln Val Glu Lys Lys Met Gly Gln Val Leu Leu Ile Ala Val Ala 
        2435                2440                2445            
Ile Ser Ser Ala Val Leu Leu Arg Thr Ala Trp Gly Trp Gly Glu Ala 
    2450                2455                2460                
Gly Ala Leu Ile Thr Ala Ala Thr Ser Thr Leu Trp Glu Gly Ser Pro 
2465                2470                2475                2480
Asn Lys Tyr Trp Asn Ser Ser Thr Ala Thr Ser Leu Cys Asn Ile Phe 
                2485                2490                2495    
Arg Gly Ser Tyr Leu Ala Gly Ala Ser Leu Ile Tyr Thr Val Thr Arg 
            2500                2505                2510        
Asn Ala Gly Leu Val Lys Arg Arg Gly Gly Gly Thr Gly Glu Thr Leu 
        2515                2520                2525            
Gly Glu Lys Trp Lys Ala Arg Leu Asn Gln Met Ser Ala Leu Glu Phe 
    2530                2535                2540                
Tyr Ser Tyr Lys Lys Ser Gly Ile Thr Glu Val Cys Arg Glu Glu Ala 
2545                2550                2555                2560
Arg Arg Ala Leu Lys Asp Gly Val Ala Thr Gly Gly His Ala Val Ser 
                2565                2570                2575    
Arg Gly Ser Ala Lys Leu Arg Trp Leu Val Glu Arg Gly Tyr Leu Gln 
            2580                2585                2590        
Pro Tyr Gly Lys Val Val Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser 
        2595                2600                2605            
Tyr Tyr Ala Ala Thr Ile Arg Lys Val Gln Glu Val Arg Gly Tyr Thr 
    2610                2615                2620                
Lys Gly Gly Pro Gly His Glu Glu Pro Met Leu Val Gln Ser Tyr Gly 
2625                2630                2635                2640
Trp Asn Ile Val Arg Leu Lys Ser Gly Val Asp Val Phe His Met Ala 
                2645                2650                2655    
Ala Glu Pro Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Ser 
            2660                2665                2670        
Ser Pro Glu Val Glu Glu Thr Arg Thr Leu Arg Val Leu Ser Met Val 
        2675                2680                2685            
Gly Asp Trp Leu Glu Lys Arg Pro Gly Ala Phe Cys Ile Lys Val Leu 
    2690                2695                2700                
Cys Pro Tyr Thr Ser Thr Met Met Glu Thr Met Glu Arg Leu Gln Arg 
2705                2710                2715                2720
Arg His Gly Gly Gly Leu Val Arg Val Pro Leu Ser Arg Asn Ser Thr 
                2725                2730                2735    
His Glu Met Tyr Trp Val Ser Gly Ala Lys Ser Asn Ile Ile Lys Ser 
            2740                2745                2750        
Val Ser Thr Thr Ser Gln Leu Leu Leu Gly Arg Met Asp Gly Pro Arg 
        2755                2760                2765            
Arg Pro Val Lys Tyr Glu Glu Asp Val Asn Leu Gly Ser Gly Thr Arg 
    2770                2775                2780                
Ala Val Ala Ser Cys Ala Glu Ala Pro Asn Met Lys Ile Ile Gly Arg 
2785                2790                2795                2800
Arg Ile Glu Arg Ile Arg Asn Glu His Ala Glu Thr Trp Phe Leu Asp 
                2805                2810                2815    
Glu Asn His Pro Tyr Arg Thr Trp Ala Tyr His Gly Ser Tyr Glu Ala 
            2820                2825                2830        
Pro Thr Gln Gly Ser Ala Ser Ser Leu Val Asn Gly Val Val Arg Leu 
        2835                2840                2845            
Leu Ser Lys Pro Trp Asp Val Val Thr Gly Val Thr Gly Ile Ala Met 
    2850                2855                2860                
Thr Asp Thr Thr Pro Tyr Gly Gln Gln Arg Val Phe Lys Glu Lys Val 
2865                2870                2875                2880
Asp Thr Arg Val Pro Asp Pro Gln Glu Gly Thr Arg Gln Val Met Asn 
                2885                2890                2895    
Ile Val Ser Ser Trp Leu Trp Lys Glu Leu Gly Lys Arg Lys Arg Pro 
            2900                2905                2910        
Arg Val Cys Thr Lys Glu Glu Phe Ile Asn Lys Val Arg Ser Asn Ala 
        2915                2920                2925            
Ala Leu Gly Ala Ile Phe Glu Glu Glu Lys Glu Trp Lys Thr Ala Val 
    2930                2935                2940                
Glu Ala Val Asn Asp Pro Arg Phe Trp Ala Leu Val Asp Arg Glu Arg 
2945                2950                2955                2960
Glu His His Leu Arg Gly Glu Cys His Ser Cys Val Tyr Asn Met Met 
                2965                2970                2975    
Gly Lys Arg Glu Lys Lys Gln Gly Glu Phe Gly Lys Ala Lys Gly Ser 
            2980                2985                2990        
Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg Phe Leu Glu Phe Glu 
        2995                3000                3005            
Ala Leu Gly Phe Leu Asn Glu Asp His Trp Met Gly Arg Glu Asn Ser 
    3010                3015                3020                
Gly Gly Gly Val Glu Gly Leu Gly Leu Gln Arg Leu Gly Tyr Ile Leu 
3025                3030                3035                3040
Glu Glu Met Asn Arg Ala Pro Gly Gly Lys Met Tyr Ala Asp Asp Thr 
                3045                3050                3055    
Ala Gly Trp Asp Thr Arg Ile Ser Lys Phe Asp Leu Glu Asn Glu Ala 
            3060                3065                3070        
Leu Ile Thr Asn Gln Met Glu Glu Gly His Arg Thr Leu Ala Leu Ala 
        3075                3080                3085            
Val Ile Lys Tyr Thr Tyr Gln Asn Lys Val Val Lys Val Leu Arg Pro 
    3090                3095                3100                
Ala Glu Gly Gly Lys Thr Val Met Asp Ile Ile Ser Arg Gln Asp Gln 
3105                3110                3115                3120
Arg Gly Ser Gly Gln Val Val Thr Tyr Ala Leu Asn Thr Phe Thr Asn 
                3125                3130                3135    
Leu Val Val Gln Leu Ile Arg Asn Met Glu Ala Glu Glu Val Leu Glu 
            3140                3145                3150        
Met Gln Asp Leu Trp Leu Leu Arg Lys Pro Glu Lys Val Thr Arg Trp 
        3155                3160                3165            
Leu Gln Ser Asn Gly Trp Asp Arg Leu Lys Arg Met Ala Val Ser Gly 
    3170                3175                3180                
Asp Asp Cys Val Val Lys Pro Ile Asp Asp Arg Phe Ala His Ala Leu 
3185                3190                3195                3200
Arg Phe Leu Asn Asp Met Gly Lys Val Arg Lys Asp Thr Gln Glu Trp 
                3205                3210                3215    
Lys Pro Ser Thr Gly Trp Ser Asn Trp Glu Glu Val Pro Phe Cys Ser 
            3220                3225                3230        
His His Phe Asn Lys Leu Tyr Leu Lys Asp Gly Arg Ser Ile Val Val 
        3235                3240                3245            
Pro Cys Arg His Gln Asp Glu Leu Ile Gly Arg Ala Arg Val Ser Pro 
    3250                3255                3260                
Gly Ala Gly Trp Ser Ile Arg Glu Thr Ala Cys Leu Ala Lys Ser Tyr 
3265                3270                3275                3280
Ala Gln Met Trp Gln Leu Leu Tyr Phe His Arg Arg Asp Leu Arg Leu 
                3285                3290                3295    
Met Ala Asn Ala Ile Cys Ser Ala Val Pro Val Asp Trp Val Pro Thr 
            3300                3305                3310        
Gly Arg Thr Thr Trp Ser Ile His Gly Lys Gly Glu Trp Met Thr Thr 
        3315                3320                3325            
Glu Asp Met Leu Met Val Trp Asn Arg Val Trp Ile Glu Glu Asn Asp 
    3330                3335                3340                
His Met Glu Asp Lys Thr Pro Val Thr Lys Trp Thr Asp Ile Pro Tyr 
3345                3350                3355                3360
Leu Gly Lys Arg Glu Asp Leu Trp Cys Gly Ser Leu Ile Gly His Arg 
                3365                3370                3375    
Pro Arg Thr Thr Trp Ala Glu Asn Ile Lys Asp Thr Val Asn Met Val 
            3380                3385                3390        
Arg Arg Ile Ile Gly Asp Glu Glu Lys Tyr Met Asp Tyr Leu Ser Thr 
        3395                3400                3405            
Gln Val Arg Tyr Leu Gly Glu Glu Gly Ser Thr Pro Gly Val Leu 
    3410                3415                3420            

<210> 14
<211> 3423
<212> PRT
<213> Zika virus


<220> 
<223> ZIKV MR766 E polyprotein (from Genbank access n°KU365778)

<400> 14
Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      
Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          
Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              
Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  
Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  
Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      
Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         
Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             
Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 
Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 
Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     
Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         
Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             
Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 
Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 
Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     
Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         
Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             
Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 
Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 
Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     
Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         
Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             
Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 
Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 
Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     
Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         
Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             
Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 
Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 
Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     
Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         
Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             
Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 
Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 
Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     
Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         
Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             
Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 
Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 
Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     
Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         
Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             
His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 
Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 
Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     
Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         
Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             
Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 
Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 
Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     
Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         
Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             
Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 
Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 
Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     
Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         
Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             
Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 
Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 
Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     
Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         
Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp Thr Trp Arg Leu Lys Arg 
        995                 1000                1005            
Ala His Leu Ile Glu Met Lys Thr Cys Glu Trp Pro Lys Ser His Thr 
    1010                1015                1020                
Leu Trp Thr Asp Gly Ile Glu Glu Ser Asp Leu Ile Ile Pro Lys Ser 
1025                1030                1035                1040
Leu Ala Gly Pro Leu Ser His His Asn Thr Arg Glu Gly Tyr Arg Thr 
                1045                1050                1055    
Gln Met Lys Gly Pro Trp His Ser Glu Glu Leu Glu Ile Arg Phe Glu 
            1060                1065                1070        
Glu Cys Pro Gly Thr Lys Val His Val Glu Glu Thr Cys Gly Thr Arg 
        1075                1080                1085            
Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser Gly Arg Val Ile Glu Glu 
    1090                1095                1100                
Trp Cys Cys Arg Glu Cys Thr Met Pro Pro Leu Ser Phe Arg Ala Lys 
1105                1110                1115                1120
Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Arg Lys Glu Pro Glu 
                1125                1130                1135    
Ser Asn Leu Val Arg Ser Met Val Thr Ala Gly Ser Thr Asp His Met 
            1140                1145                1150        
Asp His Phe Ser Leu Gly Val Leu Val Ile Leu Leu Met Val Gln Glu 
        1155                1160                1165            
Gly Leu Lys Lys Arg Met Thr Thr Lys Ile Ile Ile Ser Thr Ser Met 
    1170                1175                1180                
Ala Val Leu Val Ala Met Ile Leu Gly Gly Phe Ser Met Ser Asp Leu 
1185                1190                1195                1200
Ala Lys Leu Ala Ile Leu Met Gly Ala Thr Phe Ala Glu Met Asn Thr 
                1205                1210                1215    
Gly Gly Asp Val Ala His Leu Ala Leu Ile Ala Ala Phe Lys Val Arg 
            1220                1225                1230        
Pro Ala Leu Leu Val Ser Phe Ile Phe Arg Ala Asn Trp Thr Pro Arg 
        1235                1240                1245            
Glu Ser Met Leu Leu Ala Leu Ala Ser Cys Leu Leu Gln Thr Ala Ile 
    1250                1255                1260                
Ser Ala Leu Glu Gly Asp Leu Met Val Leu Ile Asn Gly Phe Ala Leu 
1265                1270                1275                1280
Ala Trp Leu Ala Ile Arg Ala Met Val Val Pro Arg Thr Asp Asn Ile 
                1285                1290                1295    
Thr Leu Ala Ile Leu Ala Ala Leu Thr Pro Leu Ala Arg Gly Thr Leu 
            1300                1305                1310        
Leu Val Ala Trp Arg Ala Gly Leu Ala Thr Cys Gly Gly Phe Met Leu 
        1315                1320                1325            
Leu Ser Leu Lys Gly Lys Gly Ser Val Lys Lys Asn Leu Pro Phe Val 
    1330                1335                1340                
Met Ala Leu Gly Leu Thr Ala Val Arg Leu Val Asp Pro Ile Asn Val 
1345                1350                1355                1360
Val Gly Leu Leu Leu Leu Thr Arg Ser Gly Lys Arg Ser Trp Pro Pro 
                1365                1370                1375    
Ser Glu Val Leu Thr Ala Val Gly Leu Ile Cys Ala Leu Ala Gly Gly 
            1380                1385                1390        
Phe Ala Lys Ala Asp Ile Glu Met Ala Gly Pro Met Ala Ala Val Gly 
        1395                1400                1405            
Leu Leu Ile Val Ser Tyr Val Val Ser Gly Lys Ser Val Asp Met Tyr 
    1410                1415                1420                
Ile Glu Arg Ala Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Val Thr 
1425                1430                1435                1440
Gly Asn Ser Pro Arg Leu Asp Val Ala Leu Asp Glu Ser Gly Asp Phe 
                1445                1450                1455    
Ser Leu Val Glu Asp Asp Gly Pro Pro Met Arg Glu Ile Ile Leu Lys 
            1460                1465                1470        
Val Val Leu Met Thr Ile Cys Gly Met Asn Pro Ile Ala Ile Pro Phe 
        1475                1480                1485            
Ala Ala Gly Ala Trp Tyr Val Tyr Val Lys Thr Gly Lys Arg Ser Gly 
    1490                1495                1500                
Ala Leu Trp Asp Val Pro Ala Pro Lys Glu Val Lys Lys Gly Glu Thr 
1505                1510                1515                1520
Thr Asp Gly Val Tyr Arg Val Met Thr Arg Arg Leu Leu Gly Ser Thr 
                1525                1530                1535    
Gln Val Gly Val Gly Val Met Gln Glu Gly Val Phe His Thr Met Trp 
            1540                1545                1550        
His Val Thr Lys Gly Ser Ala Leu Arg Ser Gly Glu Gly Arg Leu Asp 
        1555                1560                1565            
Pro Tyr Trp Gly Asp Val Lys Gln Asp Leu Val Ser Tyr Cys Gly Pro 
    1570                1575                1580                
Trp Lys Leu Asp Ala Ala Trp Asp Gly His Ser Glu Val Gln Leu Leu 
1585                1590                1595                1600
Ala Val Pro Pro Gly Glu Arg Ala Arg Asn Ile Gln Thr Leu Pro Gly 
                1605                1610                1615    
Ile Phe Lys Thr Lys Asp Gly Asp Ile Gly Ala Val Ala Leu Asp Tyr 
            1620                1625                1630        
Pro Ala Gly Thr Ser Gly Ser Pro Ile Leu Asp Lys Cys Gly Arg Val 
        1635                1640                1645            
Ile Gly Leu Tyr Gly Asn Gly Val Val Ile Lys Asn Gly Ser Tyr Val 
    1650                1655                1660                
Ser Ala Ile Thr Gln Gly Arg Arg Glu Glu Glu Thr Pro Val Glu Cys 
1665                1670                1675                1680
Phe Glu Pro Ser Met Leu Lys Lys Lys Gln Leu Thr Val Leu Asp Leu 
                1685                1690                1695    
His Pro Gly Ala Gly Lys Thr Arg Arg Val Leu Pro Glu Ile Val Arg 
            1700                1705                1710        
Glu Ala Ile Lys Thr Arg Leu Arg Thr Val Ile Leu Ala Pro Thr Arg 
        1715                1720                1725            
Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu Pro Val Arg 
    1730                1735                1740                
Tyr Met Thr Thr Ala Val Asn Val Thr His Ser Gly Thr Glu Ile Val 
1745                1750                1755                1760
Asp Leu Met Cys His Ala Thr Phe Thr Ser Arg Leu Leu Gln Pro Ile 
                1765                1770                1775    
Arg Val Pro Asn Tyr Asn Leu Tyr Ile Met Asp Glu Ala His Phe Thr 
            1780                1785                1790        
Asp Pro Ser Ser Ile Ala Ala Arg Gly Tyr Ile Ser Thr Arg Val Glu 
        1795                1800                1805            
Met Gly Glu Ala Ala Ala Ile Phe Met Thr Ala Thr Pro Pro Gly Thr 
    1810                1815                1820                
Arg Asp Ala Phe Pro Asp Ser Asn Ser Pro Ile Met Asp Thr Glu Val 
1825                1830                1835                1840
Glu Val Pro Glu Arg Ala Trp Ser Ser Gly Phe Asp Trp Val Thr Asp 
                1845                1850                1855    
His Ser Gly Lys Thr Val Trp Phe Val Pro Ser Val Arg Asn Gly Asn 
            1860                1865                1870        
Glu Ile Ala Ala Cys Leu Thr Lys Ala Gly Lys Arg Val Ile Gln Leu 
        1875                1880                1885            
Ser Arg Lys Thr Phe Glu Thr Glu Phe Gln Lys Thr Lys His Gln Glu 
    1890                1895                1900                
Trp Asp Phe Val Val Thr Thr Asp Ile Ser Glu Met Gly Ala Asn Phe 
1905                1910                1915                1920
Lys Ala Asp Arg Val Ile Asp Ser Arg Arg Cys Leu Lys Pro Val Ile 
                1925                1930                1935    
Leu Asp Gly Glu Arg Val Ile Leu Ala Gly Pro Met Pro Val Thr His 
            1940                1945                1950        
Ala Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg Asn Pro Asn Lys 
        1955                1960                1965            
Pro Gly Asp Glu Tyr Leu Tyr Gly Gly Gly Cys Ala Glu Thr Asp Glu 
    1970                1975                1980                
Asp His Ala His Trp Leu Glu Ala Arg Met Leu Leu Asp Asn Ile Tyr 
1985                1990                1995                2000
Leu Gln Asp Gly Leu Ile Ala Ser Leu Tyr Arg Pro Glu Ala Asp Lys 
                2005                2010                2015    
Val Ala Ala Ile Glu Gly Glu Phe Lys Leu Arg Thr Glu Gln Arg Lys 
            2020                2025                2030        
Thr Phe Val Glu Leu Met Lys Arg Gly Asp Leu Pro Val Trp Leu Ala 
        2035                2040                2045            
Tyr Gln Val Ala Ser Ala Gly Ile Thr Tyr Thr Asp Arg Arg Trp Cys 
    2050                2055                2060                
Phe Asp Gly Thr Thr Asn Asn Thr Ile Met Glu Asp Ser Val Pro Ala 
2065                2070                2075                2080
Glu Val Trp Thr Arg His Gly Glu Lys Arg Val Leu Lys Pro Arg Trp 
                2085                2090                2095    
Met Asp Ala Arg Val Cys Ser Asp His Ala Ala Leu Lys Ser Phe Lys 
            2100                2105                2110        
Glu Phe Ala Ala Gly Lys Arg Gly Ala Ala Phe Gly Val Met Glu Ala 
        2115                2120                2125            
Leu Gly Thr Leu Pro Gly His Met Thr Glu Arg Phe Gln Glu Ala Ile 
    2130                2135                2140                
Asp Asn Leu Ala Val Leu Met Arg Ala Glu Thr Gly Ser Arg Pro Tyr 
2145                2150                2155                2160
Lys Ala Ala Ala Ala Gln Leu Pro Glu Thr Leu Glu Thr Ile Met Leu 
                2165                2170                2175    
Leu Gly Leu Leu Gly Thr Val Ser Leu Gly Ile Phe Phe Val Leu Met 
            2180                2185                2190        
Arg Asn Lys Gly Ile Gly Lys Met Gly Phe Gly Met Val Thr Leu Gly 
        2195                2200                2205            
Ala Ser Ala Trp Leu Met Trp Leu Ser Glu Ile Glu Pro Ala Arg Ile 
    2210                2215                2220                
Ala Cys Val Leu Ile Val Val Phe Leu Leu Leu Val Val Leu Ile Pro 
2225                2230                2235                2240
Glu Pro Glu Lys Gln Arg Ser Pro Gln Asp Asn Gln Met Ala Ile Ile 
                2245                2250                2255    
Ile Met Val Ala Val Gly Leu Leu Gly Leu Ile Thr Ala Asn Glu Leu 
            2260                2265                2270        
Gly Trp Leu Glu Arg Thr Lys Ser Asp Leu Ser His Leu Met Gly Arg 
        2275                2280                2285            
Arg Glu Glu Gly Ala Thr Ile Gly Phe Ser Met Asp Ile Asp Leu Arg 
    2290                2295                2300                
Pro Ala Ser Ala Trp Ala Ile Tyr Ala Ala Leu Thr Thr Phe Ile Thr 
2305                2310                2315                2320
Pro Ala Val Gln His Ala Val Thr Thr Ser Tyr Asn Asn Tyr Ser Leu 
                2325                2330                2335    
Met Ala Met Ala Thr Gln Ala Gly Val Leu Phe Gly Met Gly Lys Gly 
            2340                2345                2350        
Met Pro Phe Tyr Ala Trp Asp Phe Gly Val Pro Leu Leu Met Ile Gly 
        2355                2360                2365            
Cys Tyr Ser Gln Leu Thr Pro Leu Thr Leu Ile Val Ala Ile Ile Leu 
    2370                2375                2380                
Leu Val Ala His Tyr Met Tyr Leu Ile Pro Gly Leu Gln Ala Ala Ala 
2385                2390                2395                2400
Ala Arg Ala Ala Gln Lys Arg Thr Ala Ala Gly Ile Met Lys Asn Pro 
                2405                2410                2415    
Val Val Asp Gly Ile Val Val Thr Asp Ile Asp Thr Met Thr Ile Asp 
            2420                2425                2430        
Pro Gln Val Glu Lys Lys Met Gly Gln Val Leu Leu Ile Ala Val Ala 
        2435                2440                2445            
Val Ser Ser Ala Ile Leu Ser Arg Thr Ala Trp Gly Trp Gly Glu Ala 
    2450                2455                2460                
Gly Ala Leu Ile Thr Ala Ala Thr Ser Thr Leu Trp Glu Gly Ser Pro 
2465                2470                2475                2480
Asn Lys Tyr Trp Asn Ser Ser Thr Ala Thr Ser Leu Cys Asn Ile Phe 
                2485                2490                2495    
Arg Gly Ser Tyr Leu Ala Gly Ala Ser Leu Ile Tyr Thr Val Thr Arg 
            2500                2505                2510        
Asn Ala Gly Leu Val Lys Arg Arg Gly Gly Gly Thr Gly Glu Thr Leu 
        2515                2520                2525            
Gly Glu Lys Trp Lys Ala Arg Leu Asn Gln Met Ser Ala Leu Glu Phe 
    2530                2535                2540                
Tyr Ser Tyr Lys Lys Ser Gly Ile Thr Glu Val Cys Arg Glu Glu Ala 
2545                2550                2555                2560
Arg Arg Ala Leu Lys Asp Gly Val Ala Thr Gly Gly His Ala Val Ser 
                2565                2570                2575    
Arg Gly Ser Ala Lys Leu Arg Trp Leu Val Glu Arg Gly Tyr Leu Gln 
            2580                2585                2590        
Pro Tyr Gly Lys Val Ile Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser 
        2595                2600                2605            
Tyr Tyr Ala Ala Thr Ile Arg Lys Val Gln Glu Val Lys Gly Tyr Thr 
    2610                2615                2620                
Lys Gly Gly Pro Gly His Glu Glu Pro Val Leu Val Gln Ser Tyr Gly 
2625                2630                2635                2640
Trp Asn Ile Val Arg Leu Lys Ser Gly Val Asp Val Phe His Met Ala 
                2645                2650                2655    
Ala Glu Pro Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Ser 
            2660                2665                2670        
Ser Pro Glu Val Glu Glu Ala Arg Thr Leu Arg Val Leu Ser Met Val 
        2675                2680                2685            
Gly Asp Trp Leu Glu Lys Arg Pro Gly Ala Phe Cys Ile Lys Val Leu 
    2690                2695                2700                
Cys Pro Tyr Thr Ser Thr Met Met Glu Thr Leu Glu Arg Leu Gln Arg 
2705                2710                2715                2720
Arg Tyr Gly Gly Gly Leu Val Arg Val Pro Leu Ser Arg Asn Ser Thr 
                2725                2730                2735    
His Glu Met Tyr Trp Val Ser Gly Ala Lys Ser Asn Thr Ile Lys Ser 
            2740                2745                2750        
Val Ser Thr Thr Ser Gln Leu Leu Leu Gly Arg Met Asp Gly Pro Arg 
        2755                2760                2765            
Arg Pro Val Lys Tyr Glu Glu Asp Val Asn Leu Gly Ser Gly Thr Arg 
    2770                2775                2780                
Ala Val Val Ser Cys Ala Glu Ala Pro Asn Met Lys Ile Ile Gly Asn 
2785                2790                2795                2800
Arg Ile Glu Arg Ile Arg Ser Glu His Ala Glu Thr Trp Phe Phe Asp 
                2805                2810                2815    
Glu Asn His Pro Tyr Arg Thr Trp Ala Tyr His Gly Ser Tyr Glu Ala 
            2820                2825                2830        
Pro Thr Gln Gly Ser Ala Ser Ser Leu Ile Asn Gly Val Val Arg Leu 
        2835                2840                2845            
Leu Ser Lys Pro Trp Asp Val Val Thr Gly Val Thr Gly Ile Ala Met 
    2850                2855                2860                
Thr Asp Thr Thr Pro Tyr Gly Gln Gln Arg Val Phe Lys Glu Lys Val 
2865                2870                2875                2880
Asp Thr Arg Val Pro Asp Pro Gln Glu Gly Thr Arg Gln Val Met Ser 
                2885                2890                2895    
Met Val Ser Ser Trp Leu Trp Lys Glu Leu Gly Lys His Lys Arg Pro 
            2900                2905                2910        
Arg Val Cys Thr Lys Glu Glu Phe Ile Asn Lys Val Arg Ser Asn Ala 
        2915                2920                2925            
Ala Leu Gly Ala Ile Phe Glu Glu Glu Lys Glu Trp Lys Thr Ala Val 
    2930                2935                2940                
Glu Ala Val Asn Asp Pro Arg Phe Trp Ala Leu Val Asp Lys Glu Arg 
2945                2950                2955                2960
Glu His His Leu Arg Gly Glu Cys Gln Ser Cys Val Tyr Asn Met Met 
                2965                2970                2975    
Gly Lys Arg Glu Lys Lys Gln Gly Glu Phe Gly Lys Ala Lys Gly Ser 
            2980                2985                2990        
Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg Phe Leu Glu Phe Glu 
        2995                3000                3005            
Ala Leu Gly Phe Leu Asn Glu Asp His Trp Met Gly Arg Glu Asn Ser 
    3010                3015                3020                
Gly Gly Gly Val Glu Gly Leu Gly Leu Gln Arg Leu Gly Tyr Val Leu 
3025                3030                3035                3040
Glu Glu Met Ser Arg Ile Pro Gly Gly Arg Met Tyr Ala Asp Asp Thr 
                3045                3050                3055    
Ala Gly Trp Asp Thr Arg Ile Ser Arg Phe Asp Leu Glu Asn Glu Ala 
            3060                3065                3070        
Leu Ile Thr Asn Gln Met Glu Lys Gly His Arg Ala Leu Ala Leu Ala 
        3075                3080                3085            
Ile Ile Lys Tyr Thr Tyr Gln Asn Lys Val Val Lys Val Leu Arg Pro 
    3090                3095                3100                
Ala Glu Lys Gly Lys Thr Val Met Asp Ile Ile Ser Arg Gln Asp Gln 
3105                3110                3115                3120
Arg Gly Ser Gly Gln Val Val Thr Tyr Ala Leu Asn Thr Phe Thr Asn 
                3125                3130                3135    
Leu Val Val Gln Leu Ile Arg Asn Met Glu Ala Glu Glu Val Leu Glu 
            3140                3145                3150        
Met Gln Asp Leu Trp Leu Leu Arg Arg Ser Glu Lys Val Thr Asn Trp 
        3155                3160                3165            
Leu Gln Ser Asn Gly Trp Asp Arg Leu Lys Arg Met Ala Val Ser Gly 
    3170                3175                3180                
Asp Asp Cys Val Val Lys Pro Ile Asp Asp Arg Phe Ala His Ala Leu 
3185                3190                3195                3200
Arg Phe Leu Asn Asp Met Gly Lys Val Arg Lys Asp Thr Gln Glu Trp 
                3205                3210                3215    
Lys Pro Ser Thr Gly Trp Asp Asn Trp Glu Glu Val Pro Phe Cys Ser 
            3220                3225                3230        
His His Phe Asn Lys Leu His Leu Lys Asp Gly Arg Ser Ile Val Val 
        3235                3240                3245            
Pro Cys Arg His Gln Asp Glu Leu Ile Gly Arg Ala Arg Val Ser Pro 
    3250                3255                3260                
Gly Ala Gly Trp Ser Ile Arg Glu Thr Ala Cys Leu Ala Lys Ser Tyr 
3265                3270                3275                3280
Ala Gln Met Trp Gln Leu Leu Tyr Phe His Arg Arg Asp Leu Arg Leu 
                3285                3290                3295    
Met Ala Asn Ala Ile Cys Ser Ser Val Pro Val Asp Trp Val Pro Thr 
            3300                3305                3310        
Gly Arg Thr Thr Trp Ser Ile His Gly Lys Gly Glu Trp Met Thr Thr 
        3315                3320                3325            
Glu Asp Met Leu Val Val Trp Asn Arg Val Trp Ile Glu Glu Asn Asp 
    3330                3335                3340                
His Met Glu Asp Lys Thr Pro Val Thr Lys Trp Thr Asp Ile Pro Tyr 
3345                3350                3355                3360
Leu Gly Lys Arg Glu Asp Leu Trp Cys Gly Ser Leu Ile Gly His Arg 
                3365                3370                3375    
Pro Arg Thr Thr Trp Ala Glu Asn Ile Lys Asn Thr Val Asn Met Val 
            3380                3385                3390        
Arg Arg Ile Ile Gly Asp Glu Glu Lys Tyr Met Asp Tyr Leu Ser Thr 
        3395                3400                3405            
Gln Val Arg Tyr Leu Gly Glu Glu Gly Ser Thr Pro Gly Val Leu 
    3410                3415                3420            

<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID15

<400> 15
Ala Asn Ala Lys Ala Pro Glu Thr Leu Ala Ala Arg Arg Ala Ala Ala 
1               5                   10                  15      



<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID16

<400> 16
Thr Val Asn Asp Ile Gly Tyr 
1               5           

<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID17

<400> 17
Ile Val Asn Asp Thr Gly His 
1               5           

<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID18

<400> 18
Thr Val Asn Asp Ile Gly His 
1               5           

<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID19

<400> 19
Ile Val Asn Asp Ile Gly Tyr 
1               5           

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID20

<400> 20
Thr Val Asn Asp Thr Gly Tyr 
1               5           

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID21

<400> 21
Ile Val Asn Asp Ile Gly His 
1               5           

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID22

<400> 22
Thr Val Asn Asp Thr Gly His 
1               5           

<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID23

<400> 23
Ile Val Asn Asp Thr Gly Tyr 
1               5           

<210> 24
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> rEDI-BeH819015

<400> 24
Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      
Arg Gly Ser Ala Gln Ser Thr Gly Leu Ile Arg Cys Ile Gly Val Ser 
            20                  25                  30          
Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val 
        35                  40                  45              
Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro 
    50                  55                  60                  
Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Pro Glu Asn 
65                  70                  75                  80  
Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly 
                85                  90                  95      
Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg Ala Lys 
            100                 105                 110         
Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
        115                 120                 125             
Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Ala Lys Gly Arg Leu 
    130                 135                 140                 
Ser Ser Gly His Leu Lys Cys Arg Leu Lys Met Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Gly Gly 
                165                 170                 175     
Gly His His His His His His His 
            180                 

<210> 25
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> rEDI-(Q154)

<400> 25
Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      
Arg Gly Ser Ala Gln Ser Thr Gly Leu Ile Arg Cys Ile Gly Val Ser 
            20                  25                  30          
Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val 
        35                  40                  45              
Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro 
    50                  55                  60                  
Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Pro Glu Asn 
65                  70                  75                  80  
Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly 
                85                  90                  95      
Met Ile Val Gln Asp Thr Gly His Glu Thr Asp Glu Asn Arg Ala Lys 
            100                 105                 110         
Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
        115                 120                 125             
Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Ala Lys Gly Arg Leu 
    130                 135                 140                 
Ser Ser Gly His Leu Lys Cys Arg Leu Lys Met Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Gly Gly 
                165                 170                 175     
Gly His His His His His His His 
            180                 

<210> 26
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> rEDI-MR766

<400> 26
Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      
Arg Gly Ser Ala Gln Ser Thr Gly Leu Ile Arg Cys Ile Gly Val Ser 
            20                  25                  30          
Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val 
        35                  40                  45              
Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro 
    50                  55                  60                  
Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Pro Glu Asn 
65                  70                  75                  80  
Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly 
                85                  90                  95      
Met Thr Val Asn Asp Ile Gly Tyr Glu Thr Asp Glu Asn Arg Ala Lys 
            100                 105                 110         
Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 
        115                 120                 125             
Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Ala Lys Gly Arg Leu 
    130                 135                 140                 
Ser Ser Gly His Leu Lys Cys Arg Leu Lys Met Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Gly Gly 
                165                 170                 175     
Gly His His His His His His His 
            180                 

<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQID27

<400> 27
Gly Ser Gln His Ser Gly Met Ile Val Gln Asp Thr Gly His Glu Thr 
1               5                   10                  15      
Asp Glu Asn Arg 
            20  

