                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Weissman, Drew
       Pardi, Norbert
       Mahanonda, Rangsini
       Pichyangkul, Sathit
       Champaiboon, Chantrakorn
       Wisitrasameewong, Wichaya
       Sa-Ard-Iam, Noppadol
 
<120>  The use of growth factor-encoding nucleoside-modified mRNA for 
       periodontal tissue and bone regeneration

<130>  046483-6187-00WO

<150>  US 62/965,235
<151>  2020-01-24

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  2
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  3
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDGF-BB DNA sequence

<400>  3
atgaaccgct gctgggccct gttcctgtcc ctgtgctgct acctgcgcct ggtgtccgcc       60

gagggcgacc ccatccccga ggagctgtac gagatgctgt ccgaccactc catccgctcc      120

ttcgacgacc tgcagcgcct gctgcacggc gaccccggcg aggaggacgg cgccgagctg      180

gacctgaaca tgacccgctc ccactccggc ggcgagctgg agtccctggc ccgcggccgc      240

cgctccctgg gctccctgac catcgccgag cccgccatga tcgccgagtg caagacccgc      300

accgaggtgt tcgagatctc ccgccgcctg atcgaccgca ccaacgccaa cttcctggtg      360

tggcccccct gcgtggaggt gcagcggtgc tccggctgct gcaacaaccg caacgtgcag      420

tgccgcccca cccaggtgca gctgcgcccc gtgcaggtgc gcaagatcga gatcgtgcgc      480

aagaagccca tcttcaagaa ggccaccgtg accctggagg accacctggc ctgcaagtgc      540

gagaccgtgg ccgccgcccg ccccgtgacc cgctcccccg gcggctccca ggagcagcgc      600

gccaagaccc cccagacccg cgtgaccatc cgcaccgtgc gcgtgcgccg cccccccaag      660

ggcaagcacc gcaagttcaa gcacacccac gacaagaccg ccctgaagga gaccctgggc      720

gcc                                                                    723


<210>  4
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BMP-2 DNA sequence

<400>  4
atggtggccg gcacccgctg cctgctggcc ctgctgctgc cccaggtgct gctgggcggc       60

gccgccggcc tggtgcccga gctgggccgc cgcaagttcg ccgccgcctc ctccggccgc      120

ccctcctccc agccctccga cgaggtgctg tccgagttcg agctgcgcct gctgtccatg      180

ttcggcctga agcagcgccc caccccctcc cgcgacgccg tggtgccccc ctacatgctg      240

gacctgtacc gccgccactc cggccagccc ggctcccccg cccccgacca ccgcctggag      300

cgcgccgcct cccgcgccaa caccgtgcgc tccttccacc acgaggagtc cctggaggag      360

ctgcccgaga cctccggcaa gaccacccgc cgcttcttct tcaacctgtc ctccatcccc      420

accgaggagt tcatcacctc cgccgagctg caggtgttcc gcgagcagat gcaggacgcc      480

ctgggcaaca actcctcctt ccaccaccgc atcaacatct acgagatcat caagcccgcc      540

accgccaact ccaagttccc cgtgacccgc ctgctggaca cccgcctggt gaaccagaac      600

gcctcccgct gggagtcctt cgacgtgacc cccgccgtga tgcgctggac cgcccagggc      660

cacgccaacc acggcttcgt ggtggaggtg gcccacctgg aggagaagca gggcgtgtcc      720

aagcgccacg tgcgcatctc ccgctccctg caccaggacg agcactcctg gtcccagatc      780

cgccccctgc tggtgacctt cggccacgac ggcaagggcc accccctgca caagcgcgag      840

aagcgccagg ccaagcacaa gcagcgcaag cgcctgaagt cctcctgcaa gcgccacccc      900

ctgtacgtgg acttctccga cgtgggctgg aacgactgga tcgtggcccc ccccggctac      960

cacgccttct actgccacgg cgagtgcccc ttccccctgg ccgaccacct gaactccacc     1020

aaccacgcca tcgtgcagac cctggtgaac tccgtgaact ccaagatccc caaggcctgc     1080

tgcgtgccca ccgagctgtc cgccatctcc atgctgtacc tggacgagaa cgagaaggtg     1140

gtgctgaaga actaccagga catggtggtg gagggctgcg gctgccgc                  1188


