                         SEQUENCE LISTING

<110>  Han, Jang
 
<120>  METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING VIRAL 
       INFECTION

<130>  HAN0001-401-PC

<150>  62/965,033
<151>  2020-01-23

<150>  63/050,473
<151>  2020-07-10

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Human

<400>  1

Asp Asp Glu Tyr Met Leu Ala Asp Ser Ile Ser Gly Asp Asp Leu Gly 
1               5                   10                  15      


Ser Gly Asp Leu Gly Ser Gly Asp 
            20                  


<210>  2
<211>  21
<212>  PRT
<213>  human

<400>  2

Asp Asp Glu Tyr Met Leu Ala Asp Ser Ile Ser Gly Asp Asp Leu Gly 
1               5                   10                  15      


Ser Gly Asp Leu Gly 
            20      


<210>  3
<211>  16
<212>  PRT
<213>  human

<400>  3

Asp Asp Glu Tyr Met Leu Ala Asp Ser Ile Ser Gly Asp Asp Leu Gly 
1               5                   10                  15      


<210>  4
<211>  21
<212>  PRT
<213>  human

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  5
<211>  20
<212>  PRT
<213>  human

<400>  5

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  6
<211>  24
<212>  PRT
<213>  human

<400>  6

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala 
            20                  


<210>  7
<211>  21
<212>  PRT
<213>  human

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  8
<211>  20
<212>  PRT
<213>  human

<400>  8

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  9
<211>  24
<212>  PRT
<213>  human

<400>  9

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala 
            20                  


<210>  10
<211>  411
<212>  PRT
<213>  human

<400>  10

Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
1               5                   10                  15      


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
            20                  25                  30          


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
        35                  40                  45              


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
    50                  55                  60                  


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
65                  70                  75                  80  


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
                85                  90                  95      


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
            100                 105                 110         


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
        115                 120                 125             


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
    130                 135                 140                 


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
145                 150                 155                 160 


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
                165                 170                 175     


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
            180                 185                 190         


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
        195                 200                 205             


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
    210                 215                 220                 


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
225                 230                 235                 240 


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
                245                 250                 255     


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
            260                 265                 270         


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
        275                 280                 285             


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
    290                 295                 300                 


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
305                 310                 315                 320 


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
                325                 330                 335     


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
            340                 345                 350         


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
        355                 360                 365             


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
    370                 375                 380                 


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
385                 390                 395                 400 


Gln Leu Val Leu Met Pro Lys Val Met His Tyr 
                405                 410     


<210>  11
<211>  552
<212>  PRT
<213>  human

<400>  11

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Val Gly Ala Gly Gln Arg Ala Ala Arg Ala Asp Ser His 
465                 470                 475                 480 


Ser Leu Ala Cys Trp Gly Lys Gly Ala Ser Asp Arg Thr Leu Trp Pro 
                485                 490                 495     


Thr Ala Ala Trp Ser Pro Pro Pro Ala Ala Val Leu Arg Leu Cys Arg 
            500                 505                 510         


Ser Gly Ser Gly His Cys Trp Gly Leu Arg Ser Thr Leu Ala Ser Phe 
        515                 520                 525             


Ala Cys Arg Val Ala Thr Thr Leu Pro Val Leu Glu Gly Leu Gly Pro 
    530                 535                 540                 


Ser Leu Gly Gly Gly Thr Gly Ser 
545                 550         


<210>  12
<211>  330
<212>  PRT
<213>  human

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  232
<212>  PRT
<213>  human

<400>  13

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  14
<211>  236
<212>  PRT
<213>  human

<400>  14

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  15
<211>  89
<212>  PRT
<213>  human

<400>  15

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys 
                85                  


<210>  16
<211>  14327
<212>  DNA
<213>  human

<400>  16
ggccggcgag cgggcggctg cgggcggcgc ggagcgggcg gcgcggagcg agcgagcgag       60

agagcggcgc gggccgggcc atggggtggc gggcgccggg cgcgctgctg ctggcgctgc      120

tgctgcacgg gcggctgctg gcggtgaccc atgggctgag ggcatacgat ggcttgtctc      180

tgcctgagga catagagacc gtcacagcaa gccaaatgcg ctggacacat tcgtaccttt      240

ctgatgatga gtacatgctg gctgacagca tctcaggaga cgacctgggc agtggggacc      300

tgggcagcgg ggacttccag atggtttatt tccgagccct ggtgaatttc actcgctcca      360

tcgagtacag ccctcagctg gaggatgcag gctccagaga gtttcgagag gtgtccgagg      420

ctgtggtaga cacgctggag tcggagtact tgaaaattcc cggagaccag gttgtcagtg      480

tggtgttcat caaggagctg gatggctggg tttttgtgga gctcgatgtg ggctcggaag      540

ggaatgcgga tggtgctcag attcaggaga tgctgctcag ggtcatctcc agcggctctg      600

tggcctccta cgtcacctct ccccagggat tccagttccg acgcctgggc acagtgcccc      660

agttcccaag agcctgcacg gaggccgagt ttgcctgcca cagctacaat gagtgtgtgg      720

ccctggagta tcgctgtgac cggcggcccg actgcaggga catgtctgat gagctcaatt      780

gtgaggagcc agtcctgggt atcagcccca cattctctct ccttgtggag acgacatctt      840

taccgccccg gccagagaca accatcatgc gacagccacc agtcacccac gctcctcagc      900

ccctgcttcc cggttccgtc aggcccctgc cctgtgggcc ccaggaggcc gcatgccgca      960

atgggcactg catccccaga gactacctct gcgacggaca ggaggactgc gaggacggca     1020

gcgatgagct agactgtggc cccccgccac cctgtgagcc caacgagttc ccctgcggga     1080

atggacattg tgccctcaag ctgtggcgct gcgatggtga ctttgactgt gaggaccgaa     1140

ctgatgaagc caactgcccc accaagcgtc ctgaggaagt gtgcgggccc acacagttcc     1200

gatgcgtctc taccaacatg tgcatcccag ccagcttcca ctgtgacgag gagagcgact     1260

gtcctgaccg gagcgacgag tttggctgca tgccccccca ggtggtgaca cctccccggg     1320

agtccatcca ggcttcccgg ggccagacag tgaccttcac ctgcgtggcc attggcgtcc     1380

ccacccccat catcaattgg aggctcaact ggggccacat cccctctcat cccagggtga     1440

cagtgaccag cgagggtggc cgtggcacac tgatcatccg tgatgtgaag gagtcagacc     1500

agggtgccta cacctgtgag gccatgaacg cccggggcat ggtgtttggc attcctgacg     1560

gtgtccttga gctcgtccca caacgaggcc cctgccctga cggccacttc tacctggagc     1620

acagcgccgc ctgcctgccc tgcttctgct ttggcatcac cagcgtgtgc cagagcaccc     1680

gccgcttccg ggaccagatc aggctgcgct ttgaccaacc cgatgacttc aagggtgtga     1740

atgtgacaat gcctgcgcag cccggcacgc cacccctctc ctccacgcag ctgcagatcg     1800

acccatccct gcacgagttc cagctagtag acctgtcccg ccgcttcctc gtccacgact     1860

ccttctgggc tctgcctgaa cagttcctgg gcaacaaggt ggactcctat ggcggctccc     1920

tgcgttacaa cgtgcgctac gagttggccc gtggcatgct ggagccagtg cagcggccgg     1980

acgtggtcct cgtgggtgcc gggtaccgcc tcctctcccg aggccacaca cccacccaac     2040

ctggtgctct gaaccagcgc caggtccagt tctctgagga gcactgggtc catgagtctg     2100

gccggccggt gcagcgcgcg gagctgctgc aggtgctgca gagcctggag gccgtgctca     2160

tccagaccgt gtacaacacc aagatggcta gcgtgggact tagcgacatc gccatggata     2220

ccaccgtcac ccatgccacc agccatggcc gtgcccacag tgtggaggag tgcagatgcc     2280

ccattggcta ttctggcttg tcctgcgaga gctgtgatgc ccacttcact cgggtgcctg     2340

gtgggcccta cctgggcacc tgctctggtt gcagttgcaa tggccatgcc agctcctgtg     2400

accctgtgta tggccactgc ctgaattgcc agcacaacac ggaggggcca cagtgcaaca     2460

agtgcaaggc tggcttcttt ggggacgcca tgaaggccac ggccacttcc tgccggccct     2520

gcccttgccc atacatcgat gcctcccgca gattctcaga cacttgcttc ctggacacgg     2580

atggccaagc cacatgtgac gcctgtgccc caggctacac tggccgccgc tgtgagagct     2640

gtgcccccgg atacgagggc aaccccatcc agcccggcgg gaagtgcagg cccgtcaacc     2700

aggagattgt gcgctgtgac gagcgtggca gcatggggac ctccggggag gcctgccgct     2760

gtaagaacaa tgtggtgggg cgcttgtgca atgaatgtgc tgacggctct ttccacctga     2820

gtacccgaaa ccccgatggc tgcctcaagt gcttctgcat gggtgtcagt cgccactgca     2880

ccagctcttc atggagccgt gcccagttgc atggggcctc tgaggagcct ggtcacttca     2940

gcctgaccaa cgccgcaagc acccacacca ccaacgaggg catcttctcc cccacgcccg     3000

gggaactggg attctcctcc ttccacagac tcttatctgg accctacttc tggagcctcc     3060

cttcacgctt cctgggggac aaggtgacct cctatggagg agagctgcgc ttcacagtga     3120

cccagaggtc ccagccgggc tccacacccc tgcacgggca gccgttggtg gtgctgcaag     3180

gtaacaacat catcctagag caccatgtgg cccaggagcc cagccccggc cagcccagca     3240

ccttcattgt gcctttccgg gagcaagcat ggcagcggcc cgatgggcag ccagccacac     3300

gggagcacct gctgatggca ctggcaggca tcgacaccct cctgatccga gcatcctacg     3360

cccagcagcc cgctgagagc agggtctctg gcatcagcat ggacgtggct gtgcccgagg     3420

aaaccggcca ggaccccgcg ctggaagtgg aacagtgctc ctgcccaccc gggtaccgtg     3480

ggccgtcctg ccaggactgt gacacaggct acacacgcac gcccagtggc ctctacctgg     3540

gtacctgtga acgctgcagc tgccatggcc actcagaggc ctgcgagcca gaaacaggtg     3600

cctgccaggg ctgccagcat cacacggagg gccctcggtg tgagcagtgc cagccaggat     3660

actacgggga cgcccagcgg gggacaccac aggactgcca gctgtgcccc tgctacggag     3720

accctgctgc cggccaggct gcccacactt gttttctgga cacagacggc caccccacct     3780

gtgatgcgtg ctccccaggc cacagtgggc gtcactgtga gaggtgcgcc cctggctact     3840

atggcaaccc cagccagggc cagccatgcc agagagacag ccaggtgcca gggcccatag     3900

gctgcaactg tgacccccaa ggcagcgtca gcagccagtg tgatgctgct ggtcagtgcc     3960

agtgcaaggc ccaggtagaa ggcctcactt gcagccactg ccggccccac cacttccacc     4020

tgagtgccag caacccagac ggctgcctgc cctgcttctg tatgggcatc acccagcagt     4080

gcgccagctc tgcctacaca cgccacctga tctccaccca ctttgcccct ggggacttcc     4140

aaggctttgc cctggtgaac ccacagcgaa acagccgcct gacaggagaa ttcactgtgg     4200

aacccgtgcc cgagggtgcc cagctctctt ttggcaactt tgcccaactc ggccatgagt     4260

ccttctactg gcagctgccg gagacatacc agggagacaa ggtggcggcc tacggtggga     4320

agttgcgata caccctctcc tacacagcag gcccacaggg cagcccactc tcggaccccg     4380

atgtgcagat cacgggcaac aacatcatgc tagtggcctc ccagccagcg ctgcagggcc     4440

cagagaggag gagctacgag atcatgttcc gagaggaatt ctggcgccgg cccgatgggc     4500

agccggccac acgcgagcac ctcctgatgg cactggccga cctggatgag ctcctgatcc     4560

gggccacgtt ctcctccgtg ccgctggtgg ccagcatcag cgcagtcagc ctggaggtcg     4620

cccagccggg gccctcaaac agaccccgcg ccctcgaggt ggaggagtgc cgctgcccgc     4680

caggctacat cggtctgtcc tgccaggact gtgcccccgg ctacacgcgc accgggagtg     4740

ggctctacct cggccactgc gagctatgtg aatgcaatgg ccactcagac ctgtgccacc     4800

cagagactgg ggcctgctcg caatgccagc acaacgccgc aggggagttc tgcgagcttt     4860

gtgcccctgg ctactacgga gatgccacag ccgggacgcc tgaggactgc cagccctgtg     4920

cctgcccact gaccaaccca gagaacatgt tttcccgcac ctgtgagagc ctgggagccg     4980

gcgggtaccg ctgcacggcc tgcgaacccg gctacactgg ccagtactgt gagcagtgtg     5040

gcccaggtta cgtgggtaac cccagtgtgc aagggggcca gtgcctgcca gagacaaacc     5100

aagccccact ggtggtcgag gtccatcctg ctcgaagcat agtgccccaa ggtggctccc     5160

actccctgcg gtgtcaggtc agtgggagcc caccccacta cttctattgg tcccgtgagg     5220

atgggcggcc tgtgcccagc ggcacccagc agcgacatca aggctccgag ctccacttcc     5280

ccagcgtcca gccctcggat gctggggtct acatttgcac ctgccgtaat ctccaccaat     5340

ccaataccag ccgggcagag ctgctggtca ctgaggctcc aagcaagccc atcacagtga     5400

ctgtggagga gcagcggagc cagagcgtgc gccccggagc tgacgtcacc ttcatctgca     5460

cagccaaaag caagtcccca gcctataccc tggtgtggac ccgcctgcac aacgggaaac     5520

tgcccacccg agccatggat ttcaatggca tcctgaccat tcgcaacgtc cagctgagtg     5580

atgcaggcac ctacgtgtgc accggctcca acatgtttgc catggaccag ggcacagcca     5640

ctctacatgt gcaggcctcg ggcaccttgt ccgcccccgt ggtctccatc catccgccac     5700

agctcacagt gcagcccggg caactggcgg agttccgctg cagcgccaca gggagcccca     5760

cgcccaccct cgagtggaca gggggccccg gcggccagct ccctgcgaag gcacaaatcc     5820

acggcggcat cctgcgcctg ccagctgtcg agcccacgga tcaggcccag tacttgtgcc     5880

gagcccacag cagcgctggg cagcaggtgg ccagggctgt gctccacgtg catgggggcg     5940

gtgggcccag agtccaagtg agcccagaga ggacccaggt ccacgcaggc cggaccgtca     6000

ggctgtactg cagggctgca ggcgtgccta gcgccaccat cacctggagg aaggaagggg     6060

gcagcctccc accacaggcc cggtcagagc gcacagacat cgcgacactg ctcatcccag     6120

ccatcacgac tgctgacgcc ggcttctacc tctgcgtggc caccagccct gcaggcactg     6180

cccaggcccg gatgcaagtg gttgtccttt cagcctcaga tgccagccca ccgggggtca     6240

agattgagtc ctcatcgcct tctgtgacag aagggcaaac actcgacctc aactgtgtgg     6300

tggcagggtc agcccatgcc caggtcacct ggtacaggcg agggggtagc ctgcctcccc     6360

acacccaggt gcacggctcc cgtctgcggc tcccccaggt ctcaccagct gattctggag     6420

aatatgtgtg ccgtgtggag aatggatcgg gccccaagga ggcctccatt actgtgtctg     6480

tgctccacgg cacccattct ggccccagct acaccccagt gcccggcagc acccggccca     6540

tccgcatcga gccctcctcc tcacacgtgg cggaagggca gaccctggat ctgaactgcg     6600

tggtgcccgg gcaggcccac gcccaggtca cgtggcacaa gcgtgggggc agcctccctg     6660

cccggcacca gacccacggc tcgctgctgc ggctgcacca ggtgaccccg gccgactcag     6720

gcgagtatgt gtgccatgtg gtgggcacct ccggccccct agaggcctca gtcctggtca     6780

ccatcgaagc ctctgtcatc cctggaccca tcccacctgt caggatcgag tcttcatcct     6840

ccacagtggc cgagggccag accctggatc tgagctgcgt ggtggcaggg caggcccacg     6900

cccaggtcac atggtacaag cgtgggggca gcctccctgc ccggcaccag gttcgtggct     6960

cccgcctgta catcttccag gcctcacctg ccgatgcggg acagtacgtc tgccgggcca     7020

gcaacggcat ggaggcctcc atcacggtca cagtaactgg gacccagggg gccaacttag     7080

cctaccctgc cggcagcacc cagcccatcc gcatcgagcc ctcctcctcg caagtggcgg     7140

aagggcagac cctggatctg aactgcgtgg tgcccgggca gtcccatgcc caggtcacgt     7200

ggcacaagcg tgggggcagc ctccctgtcc ggcaccagac ccacggctcc ctgctgagac     7260

tctaccaagc gtcccccgcc gactcgggcg agtacgtgtg ccgagtgttg ggcagctccg     7320

tgcctctaga ggcctctgtc ctggtcacca ttgagcctgc gggctcagtg cctgcacttg     7380

gggtcacccc cacggtccgg atcgagtcat cgtcttcgca agtggccgag gggcagaccc     7440

tggacctgaa ctgcctcgtt gctggtcagg cccatgccca ggtcacgtgg cacaagcgcg     7500

ggggcagcct cccggcccgg caccaggtgc atggctcgag gctacgcctg ctccaggtga     7560

ccccagctga ttcaggggag tacgtgtgcc gtgtggtcgg cagctcaggt acccaggaag     7620

cctcagtcct tgtcaccatc cagcagcgcc ttagtggctc ccactcccag ggtgtggcgt     7680

accccgtccg catcgagtcc tcctcagcct ccctggccaa tggacacacc ctggacctca     7740

actgcctggt tgccagccag gctccccaca ccatcacctg gtataagcgt ggaggcagct     7800

tacccagccg gcaccagatc gtgggctccc ggctgcggat ccctcaggtg actccggcag     7860

actcgggcga gtacgtgtgt cacgtcagta acggtgcagg ctcccgggag acctcgctca     7920

tcgtcaccat ccagggcagc ggttcctccc acgtgcccag cgtctcccca ccgatcagga     7980

tcgagtcgtc ttcccccacg gtggtggaag ggcagacctt ggatctgaac tgcgtggtcg     8040

ccaggcagcc ccaggctatc atcacatggt acaagcgtgg gggcagcctt ccctcccgac     8100

accagaccca tggctcccac ctgcggttgc accaaatgtc tgtggctgac tcgggcgagt     8160

atgtgtgccg ggccaacaac aacatcgatg ccctggaggc ctccatcgtc atctccgtct     8220

cccctagcgc cggcagcccc tccgcccctg gcagctccat gcccatcaga attgagtcat     8280

cctcctcaca cgtggccgaa ggggagaccc tggatctgaa ctgcgtggtc cccgggcagg     8340

cccatgccca ggtcacttgg cacaagcgtg ggggcagcct ccccagtcac catcagaccc     8400

gcggctcacg gctgcggctg caccatgtgt ccccggccga ctcgggtgaa tacgtgtgcc     8460

gggtgatggg cagctctggc cccctggagg cctcagtcct ggtcaccatc gaagcctctg     8520

gctcaagtgc tgtccacgtc cccgccccag gtggagcccc acccatccgc atcgagccct     8580

cctcctcccg agtggcagaa gggcagaccc tggatctgaa gtgcgtggtg cccgggcagg     8640

cccacgccca ggtcacatgg cacaagcgtg gaggaaacct ccctgcccgg caccaggtcc     8700

acggcccact gctgaggctg aaccaggtgt ccccggctga ctctggcgag tactcgtgcc     8760

aagtgaccgg aagctcaggc accctggagg catctgtcct ggtcacaatt gagccctcca     8820

gcccaggacc cattcctgct ccaggactgg cccagcccat ctacatcgag gcctcctctt     8880

cacacgtgac tgaagggcag actctggatc tgaactgtgt ggtgcccggg caggcccatg     8940

cccaggtcac gtggtacaag cgcgggggca gcctccccgc ccggcaccag acccatggct     9000

cccagctgcg gctccacctc gtctcccctg ccgactcagg cgagtatgtg tgtcgtgcag     9060

ccagcggccc aggccctgag caagaagcct ccttcacagt caccgtcccg cccagtgagg     9120

ggtcttccta ccgccttagg agcccggtca tctccatcga cccgcccagc agcaccgtgc     9180

agcagggcca ggatgccagc ttcaagtgcc tcatccatga cggggcagcc cccatcagcc     9240

tcgagtggaa gacccggaac caggagctgg aggacaacgt ccacatcagt cccaatggct     9300

ccatcatcac catcgtgggc acccggccca gcaaccacgg tacctaccgc tgcgtggcct     9360

ccaatgccta cggtgtggcc cagagtgtgg tgaacctcag tgtgcacggg ccccctacag     9420

tgtccgtgct ccccgagggc cccgtgtggg tgaaagtggg aaaggctgtc accctggagt     9480

gtgtcagtgc cggggagccc cgctcctctg ctcgttggac ccggatcagc agcacccctg     9540

ccaagttgga gcagcggaca tatgggctca tggacagcca cgcggtgctg cagatttcat     9600

cagctaaacc atcagatgcg ggcacttatg tgtgccttgc tcagaatgca ctaggcacag     9660

cacagaagca ggtggaggtg atcgtggaca cgggcgccat ggccccaggg gcccctcagg     9720

tccaagctga agaagctgag ctgactgtgg aggctggaca cacggccacc ttgcgctgct     9780

cagccacagg cagccccgcg cccaccatcc actggtccaa gctgcgttcc ccactgccct     9840

ggcagcaccg gctggaaggt gacacactca tcataccccg ggtagcccag caggactcgg     9900

gccagtacat ctgcaatgcc actagccctg ctgggcacgc tgaggccacc atcatcctgc     9960

acgtggagag cccaccatat gccaccacgg tcccagagca cgcttcggtg caggcagggg    10020

agacggtgca gctccagtgc ctggctcacg ggacaccccc actcaccttc cagtggagcc    10080

gcgtgggcag cagccttcct gggagggcga ccgccaggaa cgagctgctg cactttgagc    10140

gtgcagcccc tgaggactca ggccgctacc gctgccgggt caccaacaag gtgggctcag    10200

ccgaggcctt tgcccagctg ctcgtccaag gccctcccgg ctctctccct gccacctcca    10260

tcccagcagg gtccacgccc accgtgcagg tcacgcctca gctagagacc aagagcattg    10320

gggccagcgt tgagttccac tgtgctgtgc ccagcgacca gggtacccag ctccgttggt    10380

tcaaggaagg gggtcagctg cctccgggtc acagcgtgca ggatggggtg ctccgaatcc    10440

agaacttgga ccagagctgc caagggacgt atatatgcca ggcccatgga ccttggggga    10500

aggcccaggc cagtgcccag ctggttatcc aagccctgcc ctcggtgctc atcaacatcc    10560

ggacctctgt gcagaccgtg gtggttggcc acgccgtgga gttcgaatgc ctggcactgg    10620

gtgaccccaa gcctcaggtg acatggagca aagttggagg gcacctgcgg ccaggcattg    10680

tgcagagcgg aggtgtcgtc aggatcgccc acgtagagct ggctgatgcg ggacagtatc    10740

gctgcactgc caccaacgca gctggcacca cacaatccca cgtcctgctg cttgtgcaag    10800

ccttgcccca gatctcaatg ccccaagaag tccgtgtgcc tgctggttct gcagctgtct    10860

tcccctgcat agcctcaggc taccccactc ctgacatcag ctggagcaag ctggatggca    10920

gcctgccacc tgacagccgc ctggagaaca acatgctgat gctgccctca gtccgacccc    10980

aggacgcagg tacctacgtc tgcaccgcca ctaaccgcca gggcaaggtc aaagcctttg    11040

cccacctgca ggtgccagag cgggtggtgc cctacttcac gcagaccccc tactccttcc    11100

taccgctgcc caccatcaag gatgcctaca ggaagttcga gatcaagatc accttccggc    11160

ccgactcagc cgatgggatg ctgctgtaca atgggcagaa gcgagtccca gggagcccca    11220

ccaacctggc caaccggcag cccgacttca tctccttcgg cctcgtgggg ggaaggcccg    11280

agttccggtt cgatgcaggc tcaggcatgg ccaccatccg ccatcccaca ccactggccc    11340

tgggccattt ccacaccgtg accctgctgc gcagcctcac ccagggctcc ctgattgtgg    11400

gtgacctggc cccggtcaat gggacctccc agggcaagtt ccagggcctg gatctgaacg    11460

aggaactcta cctgggtggc tatcctgact atggtgccat ccccaaggcg gggctgagca    11520

gcggcttcat aggctgtgtc cgggagctgc gcatccaggg cgaggagatc gtcttccatg    11580

acctcaacct cacggcgcac ggcatctccc actgccccac ctgtcgggac cggccctgcc    11640

agaatggcgg tcagtgccat gactctgaga gcagcagcta cgtgtgcgtc tgcccagctg    11700

gcttcaccgg gagccgctgt gagcactcgc aggccctgca ctgccatcca gaggcctgtg    11760

ggcccgacgc cacctgtgtg aaccggcctg acggtcgagg ctacacctgc cgctgccacc    11820

tgggccgctc ggggttgcgg tgtgaggaag gtgtgacagt gaccaccccc tcgctgtcgg    11880

gtgctggctc ctacctggca ctgcccgccc tcaccaacac acaccacgag ctacgcctgg    11940

acgtggagtt caagccactc gcccctgacg gggtcctgct gttcagcggg gggaagagcg    12000

ggcctgtgga ggacttcgtg tccctggcga tggtgggcgg ccacctggag ttccgctatg    12060

agttggggtc agggctggcc gttctgcgga gcgccgagcc gctggccctg ggccgctggc    12120

accgtgtgtc tgcagagcgt ctcaacaagg acggcagcct gcgggtgaat ggtggacgcc    12180

ctgtgctgcg ctcctcgccc ggcaagagcc agggcctcaa cctgcacacc ctgctctacc    12240

tggggggtgt ggagccttcc gtgccactgt ccccggccac caacatgagc gctcacttcc    12300

gcggctgtgt gggcgaggtg tcagtgaatg gcaaacggct ggacctcacc tacagtttcc    12360

taggcagcca gggcatcggg caatgctatg atagctcccc atgtgagcgc cagccttgcc    12420

aacatggtgc cacgtgcatg cccgctggcg agtatgagtt ccagtgcctg tgtcgagatg    12480

gattcaaagg agacctgtgt gagcacgagg agaacccctg ccagctccgt gaaccctgtc    12540

tgcatggggg cacctgccag ggcacccgct gcctctgcct ccctggcttc tctggcccac    12600

gctgccaaca aggctctgga catggcatag cagagtccga ctggcatctt gaaggcagcg    12660

ggggcaatga tgcccctggg cagtacggag cctatttcca cgatgatggc ttcctcgcct    12720

tccctggcca tgtcttctcc aggagcctgc ccgaggtgcc cgagaccatc gagctggagg    12780

ttcggaccag cacagccagt ggcctcctgc tctggcaggg tgtggaggtg ggagaggccg    12840

gccaaggcaa ggacttcatc agcctcgggc ttcaagacgg gcaccttgtc ttcaggtacc    12900

agctgggtag tggggaggcc cgcctggtct ctgaggaccc catcaatgac ggcgagtggc    12960

accgggtgac agcactgcgg gagggccgca gaggttccat ccaagtcgac ggtgaggagc    13020

tggtcagcgg ccggtcccca ggtcccaacg tggcagtcaa cgccaagggc agcgtctaca    13080

tcggcggagc ccctgacgtg gccacgctga ccgggggcag attctcctcg ggcatcacag    13140

gctgtgtcaa gaacctggtg ctgcactcgg cccgacccgg cgccccgccc ccacagcccc    13200

tggacctgca gcaccgcgcc caggccgggg ccaacacacg cccctgcccc tcgtaggcac    13260

ctgcctgccc cacacggact cccgggccac gccccagccc gacaatgtcg agtatattat    13320

tattaatatt attatgaatt tttgtaagaa accgaggcga tgccacgctt tgctgctacc    13380

gccctgggct ggactggagg tgggcatgcc accctcacac acacagctgg gcaaagccac    13440

aaggctggcc agcaaggcag gttggatggg agtgggcacc tcagaaagtc accaggactt    13500

ggggtcagga acagtggctg ggtgggccca gaactgcccc cactgtcccc ctacccaccg    13560

atggagcccc cagatagagc tgggtggcct gtttctgcag cccttgggca gttctcactc    13620

ctaggagagc caacctcggc ttgtgggctg gtgccccaca gctacctgag acgggcatcg    13680

caggagtctc tgccacccac tcaggattgg gaattgtctt tagtgccggc tgtggagcaa    13740

aaggcagctc acccctgggc aggcggtccc catccccacc agctcgtttt tcagcacccc    13800

cacccacctc cacccagccc ctggcacctc ctctggcaga ctccccctcc taccacgtcc    13860

tcctggcctg cattcccacc ccctcctgcc agcacacagc ctggggtccc tccctcaggg    13920

gctgtaaggg aaggcccacc ccaactctta ccaggagctg ctacaggcag agcccagcac    13980

tgatagggcc ccgcccaccg ggccccgccc accccaggcc acatccccac ccatctggaa    14040

gtgaaggccc agggactcct ccaacagaca acggacggac ggatgccgct ggtgctcagg    14100

aagagctagt gccttaggtg ggggaaggca ggactcacga ctgagagaga gaggaggggg    14160

atatgaccac cctgccccat ctgcaggagc ctgaagatcc agctcaagtg ccatcctgcc    14220

agtggccccc agactgtggg gttgggacgc ctggcctctg tgtcctagaa gggaccctcc    14280

tgtggtcttt gtcttgattt ttcttaataa acggtgctat ccccgcc                  14327


<210>  17
<211>  123
<212>  PRT
<213>  human

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Pro Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Glu His Ser Ile Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Ala His Arg Ser Ser Trp Ser Gly Lys Arg Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Ser Ser Ala 
        115                 120             


<210>  18
<211>  65
<212>  PRT
<213>  human

<400>  18

Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile Ser Gly Asp 
1               5                   10                  15      


Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Cys Thr Glu Ala 
            20                  25                  30          


Glu Phe Ala Cys His Ser Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg 
        35                  40                  45              


Cys Asp Arg Arg Pro Asp Cys Arg Asp Met Ser Asp Glu Leu Asn Cys 
    50                  55                  60                  


Glu 
65  


<210>  19
<211>  20
<212>  DNA
<213>  Bacteriophage T7

<400>  19
taatacgact cactataggg                                                   20


<210>  20
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Asp Glu Asp Met Ala Asp Ser Ile Ser Gly Asp Asp Leu Gly Ser 
1               5                   10                  15      


Gly Asp Leu Gly Ser Gly Asp 
            20              


<210>  21
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Asp Glu Asp Met Ala Asp Ser Ile Thr Gly Asp Asp Leu Gly Thr 
1               5                   10                  15      


Gly Asp Leu Gly Thr Gly Asp 
            20              


<210>  22
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ser Gly Gly Gly Met Val Glu Gln Val Ser Gly Asp Cys Asp Asp 
1               5                   10                  15      


Glu Asp Gly Cys Gly Gly Ser Gly Ser Gly Glu Val Lys Arg 
            20                  25                  30  


<210>  23
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  23

Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly Asp Leu 
1               5                   10                  15      


Asp Asp Leu Glu Asp Ser Met Ile Gly Pro 
            20                  25      


<210>  24
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P6Fc-HS Construct

<400>  24
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gaggaacagg ccaagacatt tctggacaag tttaaccacg aagccgaaga cctgttctat      120

cagagctccg gcctggggaa gggcgacttc aggggctcga gtgctgagcc caaatcttgt      180

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      240

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      300

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      360

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      420

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      480

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      540

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      600

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      660

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      720

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      780

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      840

ctctccctgt ctccgggtaa agcacgtacg ggcggcggcg gcggatccga tgatgagtac      900

atgctggctg acagcatctc aggagacgac ctgggcagtg gggatctcgg atcaggcgac      960

atctag                                                                 966


<210>  25
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 Leader

<400>  25
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60


<210>  26
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2 from P6Fc-HS construct

<400>  26
gaggaacagg ccaagacatt tctggacaag tttaaccacg aagccgaaga cctgttctat       60

cagagctccg gcctggggaa gggcgacttc agg                                    93


<210>  27
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 1 in P6Fc-HS

<400>  27
ggctcgagtg ctgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca       60


<210>  28
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc

<400>  28
cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc       60

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      120

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      180

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      240

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      300

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      360

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      420

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      480

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc      540

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct      600

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                   648


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 2 in P6Fc-HS

<400>  29
gcacgtacgg gcggcggcgg cggatcc                                           27


<210>  30
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heparan sulfate

<400>  30
gatgatgagt acatgctggc tgacagcatc tcaggagacg acctgggcag tggggatctc       60

ggatcaggcg ac                                                           72


<210>  31
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full-length P6Fc-HS construct

<400>  31

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
            20                  25                  30          


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Gly Leu Gly Lys Gly 
        35                  40                  45              


Asp Phe Arg Gly Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His 
    50                  55                  60                  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
65                  70                  75                  80  


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                85                  90                  95      


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            100                 105                 110         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        115                 120                 125             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    130                 135                 140                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
145                 150                 155                 160 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                165                 170                 175     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            180                 185                 190         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        195                 200                 205             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    210                 215                 220                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
225                 230                 235                 240 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                245                 250                 255     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            260                 265                 270         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala 
        275                 280                 285             


Arg Thr Gly Gly Gly Gly Gly Ser Asp Asp Glu Tyr Met Leu Ala Asp 
    290                 295                 300                 


Ser Ile Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp 
305                 310                 315                 320 


Ile 
    


<210>  32
<211>  3066
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full-length Ace2Fc-HS nucleotide sequence

<400>  32
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggctcgaggg ctgctcagtc caccattgag gaacaggcca agacattttt ggacaagttt      120

aaccacgaag ccgaagacct gttctatcaa agttcacttg cttcttggaa ttataacacc      180

aatattactg aagagaatgt ccaaaacatg aataatgctg gggacaaatg gtctgccttt      240

ttaaaggaac agtccacact tgcccaaatg tatccactac aagaaattca gaatctcaca      300

gtcaagcttc agctgcaggc tcttcagcaa aatgggtctt cagtgctctc agaagacaag      360

agcaaacggt tgaacacaat tctaaataca atgagcacca tctacagtac tggaaaagtt      420

tgtaacccag ataatccaca agaatgctta ttacttgaac caggtttgaa tgaaataatg      480

gcaaacagtt tagactacaa tgagaggctc tgggcttggg aaagctggag atctgaggtc      540

ggcaagcagc tgaggccatt atatgaagag tatgtggtct tgaaaaatga gatggcaaga      600

gcaaatcatt atgaggacta tggggattat tggagaggag actatgaagt aaatggggta      660

gatggctatg actacagccg cggccagttg attgaagatg tggaacatac ctttgaagag      720

attaaaccat tatatgaaca tcttcatgcc tatgtgaggg caaagttgat gaatgcctat      780

ccttcctata tcagtccaat tggatgcctc cctgctcatt tgcttggtga tatgtggggt      840

agattttgga caaatctgta ctctttgaca gttccctttg gacagaaacc aaacatagat      900

gttactgatg caatggtgga ccaggcctgg gatgcacaga gaatattcaa ggaggccgag      960

aagttctttg tatctgttgg tcttcctaat atgactcaag gattctggga aaattccatg     1020

ctaacggacc caggaaatgt tcagaaagca gtctgccatc ccacagcttg ggacctgggg     1080

aagggcgact tcaggatcct tatgtgcaca aaggtgacaa tggacgactt cctgacagct     1140

catcatgaga tggggcatat ccagtatgat atggcatatg ctgcacaacc ttttctgcta     1200

agaaatggag ctaatgaagg attccatgaa gctgttgggg aaatcatgtc actttctgca     1260

gccacaccta agcatttaaa atccattggt cttctgtcac ccgattttca agaagacaat     1320

gaaacagaaa taaacttcct gctcaaacaa gcactcacga ttgttgggac tctgccattt     1380

acttacatgt tagagaagtg gaggtggatg gtctttaaag gggaaattcc caaagaccag     1440

tggatgaaaa agtggtggga gatgaagcga gagatagttg gggtggtgga acctgtgccc     1500

catgatgaaa catactgtga ccccgcatct ctgttccatg tttctaatga ttactcattc     1560

attcgatatt acacaaggac cctttaccaa ttccagtttc aagaagcact ttgtcaagca     1620

gctaaacatg aaggccctct gcacaaatgt gacatctcaa actctacaga agctggacag     1680

aaactgttca atatgctgag gcttggaaaa tcagaaccct ggaccctagc attggaaaat     1740

gttgtaggag caaagaacat gaatgtaagg ccactgctca actactttga gcccttattt     1800

acctggctga aagaccagaa caagaattct tttgtgggat ggagtaccga ctggagtcca     1860

tatgcagacc aaagcatcaa agtgaggata agcctaaaat cagctcttgg agataaagca     1920

tatgaatgga acgacaatga aatgtacctg ttccgatcat ctgttgcata tgctatgagg     1980

cagtactttt taaaagtaaa aaatcagatg attctttttg gggaggagga tgtgcgagtg     2040

gctaatttga aaccaagaat ctcctttaat ttctttgtca ctgcacctaa aaatgtgtct     2100

gatatcattc ctagaactga agttgaaaag gccatcagga tgtcccggag ccgtatcaat     2160

gatgctttcc gtctgaatga caacagccta gagtttctgg ggatacagcc aacacttgga     2220

cctcctaacc agccccctgt ttccgggccc tcgggctcga gtgctgagcc caaatcttgt     2280

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     2340

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     2400

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2460

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2520

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2580

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2640

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     2700

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2760

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2820

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2880

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2940

ctctccctgt ctccgggtaa agcacgtacg ggcggcggcg gcggatccga tgatgagtac     3000

atgctggctg acagcatctc aggagacgac ctgggcagtg gggatctcgg atcaggcgac     3060

atctag                                                                3066


<210>  33
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 1 in Ace2Fc-HS

<400>  33
ggctcgagg                                                                9


<210>  34
<211>  2175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2 in Ace2Fc-HS

<400>  34
gctgctcagt ccaccattga ggaacaggcc aagacatttt tggacaagtt taaccacgaa       60

gccgaagacc tgttctatca aagttcactt gcttcttgga attataacac caatattact      120

gaagagaatg tccaaaacat gaataatgct ggggacaaat ggtctgcctt tttaaaggaa      180

cagtccacac ttgcccaaat gtatccacta caagaaattc agaatctcac agtcaagctt      240

cagctgcagg ctcttcagca aaatgggtct tcagtgctct cagaagacaa gagcaaacgg      300

ttgaacacaa ttctaaatac aatgagcacc atctacagta ctggaaaagt ttgtaaccca      360

gataatccac aagaatgctt attacttgaa ccaggtttga atgaaataat ggcaaacagt      420

ttagactaca atgagaggct ctgggcttgg gaaagctgga gatctgaggt cggcaagcag      480

ctgaggccat tatatgaaga gtatgtggtc ttgaaaaatg agatggcaag agcaaatcat      540

tatgaggact atggggatta ttggagagga gactatgaag taaatggggt agatggctat      600

gactacagcc gcggccagtt gattgaagat gtggaacata cctttgaaga gattaaacca      660

ttatatgaac atcttcatgc ctatgtgagg gcaaagttga tgaatgccta tccttcctat      720

atcagtccaa ttggatgcct ccctgctcat ttgcttggtg atatgtgggg tagattttgg      780

acaaatctgt actctttgac agttcccttt ggacagaaac caaacataga tgttactgat      840

gcaatggtgg accaggcctg ggatgcacag agaatattca aggaggccga gaagttcttt      900

gtatctgttg gtcttcctaa tatgactcaa ggattctggg aaaattccat gctaacggac      960

ccaggaaatg ttcagaaagc agtctgccat cccacagctt gggacctggg gaagggcgac     1020

ttcaggatcc ttatgtgcac aaaggtgaca atggacgact tcctgacagc tcatcatgag     1080

atggggcata tccagtatga tatggcatat gctgcacaac cttttctgct aagaaatgga     1140

gctaatgaag gattccatga agctgttggg gaaatcatgt cactttctgc agccacacct     1200

aagcatttaa aatccattgg tcttctgtca cccgattttc aagaagacaa tgaaacagaa     1260

ataaacttcc tgctcaaaca agcactcacg attgttggga ctctgccatt tacttacatg     1320

ttagagaagt ggaggtggat ggtctttaaa ggggaaattc ccaaagacca gtggatgaaa     1380

aagtggtggg agatgaagcg agagatagtt ggggtggtgg aacctgtgcc ccatgatgaa     1440

acatactgtg accccgcatc tctgttccat gtttctaatg attactcatt cattcgatat     1500

tacacaagga ccctttacca attccagttt caagaagcac tttgtcaagc agctaaacat     1560

gaaggccctc tgcacaaatg tgacatctca aactctacag aagctggaca gaaactgttc     1620

aatatgctga ggcttggaaa atcagaaccc tggaccctag cattggaaaa tgttgtagga     1680

gcaaagaaca tgaatgtaag gccactgctc aactactttg agcccttatt tacctggctg     1740

aaagaccaga acaagaattc ttttgtggga tggagtaccg actggagtcc atatgcagac     1800

caaagcatca aagtgaggat aagcctaaaa tcagctcttg gagataaagc atatgaatgg     1860

aacgacaatg aaatgtacct gttccgatca tctgttgcat atgctatgag gcagtacttt     1920

ttaaaagtaa aaaatcagat gattcttttt ggggaggagg atgtgcgagt ggctaatttg     1980

aaaccaagaa tctcctttaa tttctttgtc actgcaccta aaaatgtgtc tgatatcatt     2040

cctagaactg aagttgaaaa ggccatcagg atgtcccgga gccgtatcaa tgatgctttc     2100

cgtctgaatg acaacagcct agagtttctg gggatacagc caacacttgg acctcctaac     2160

cagccccctg tttcc                                                      2175


<210>  35
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 2 in Ace2Fc-HS

<400>  35
gggccctcgg gctcgagtgc tgagcccaaa tcttgtgaca aaactcacac atgcccaccg       60

tgcccagca                                                               69


<210>  36
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 3 in Ace2Fc-HS

<400>  36
gcacgtacgg gcggcggcgg cggatcc                                           27


<210>  37
<211>  1021
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Ace2Fc-HS

<400>  37

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Arg Ala Ala Gln Ser Thr Ile Glu Glu Gln 
            20                  25                  30          


Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe 
        35                  40                  45              


Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu 
    50                  55                  60                  


Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe 
65                  70                  75                  80  


Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile 
                85                  90                  95      


Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly 
            100                 105                 110         


Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu 
        115                 120                 125             


Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp 
    130                 135                 140                 


Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met 
145                 150                 155                 160 


Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp 
                165                 170                 175     


Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val 
            180                 185                 190         


Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly 
        195                 200                 205             


Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp 
    210                 215                 220                 


Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu 
225                 230                 235                 240 


Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu 
                245                 250                 255     


Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala 
            260                 265                 270         


His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser 
        275                 280                 285             


Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala 
    290                 295                 300                 


Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu 
305                 310                 315                 320 


Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp 
                325                 330                 335     


Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys 
            340                 345                 350         


His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met 
        355                 360                 365             


Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met 
    370                 375                 380                 


Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu 
385                 390                 395                 400 


Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met 
                405                 410                 415     


Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu 
            420                 425                 430         


Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu 
        435                 440                 445             


Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu 
    450                 455                 460                 


Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln 
465                 470                 475                 480 


Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val 
                485                 490                 495     


Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe 
            500                 505                 510         


His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu 
        515                 520                 525             


Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu 
    530                 535                 540                 


Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln 
545                 550                 555                 560 


Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu 
                565                 570                 575     


Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu 
            580                 585                 590         


Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys 
        595                 600                 605             


Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln 
    610                 615                 620                 


Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala 
625                 630                 635                 640 


Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala 
                645                 650                 655     


Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu 
            660                 665                 670         


Phe Gly Glu Glu Asp Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser 
        675                 680                 685             


Phe Asn Phe Phe Val Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro 
    690                 695                 700                 


Arg Thr Glu Val Glu Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn 
705                 710                 715                 720 


Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln 
                725                 730                 735     


Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro Val Ser Gly Pro Ser Gly 
            740                 745                 750         


Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Arg Thr Gly Gly 
            980                 985                 990         


Gly Gly Gly Ser Asp Asp Glu Tyr  Met Leu Ala Asp Ser  Ile Ser Gly 
        995                 1000                 1005             


Asp Asp  Leu Gly Ser Gly Asp  Leu Gly Ser Gly Asp  Ile 
    1010                 1015                 1020     


<210>  38
<211>  1227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete nucleotide sequence of P61Fc-HS

<400>  38
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gcagcagctg ctcagtccac cattgaggaa caggccaaga catttttgga caagtttaac      120

cacgaagccg aagacctgtt ctatcaaagt tcacttgctt cttggaatta taacaccaat      180

attactgaag agaatgtcca aaacatgaat aatgctgggg acaaatggtc tgccttttta      240

aaggaacagt ccacacttgc ccaaatgtat ccactacaag aaattcagaa tctcacagga      300

ggaggacaag gattctggga aaattccatg ctaacggacc caggaaatgt tcagaaagca      360

gtctgccatc ccacagcttg ggacctgggg aagggcgact tcagggggcc ctcgggctcg      420

agtgctgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      480

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      540

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      600

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      660

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      720

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      780

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      840

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      900

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      960

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1020

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1080

aaccactaca cgcagaagag cctctccctg tctccgggta aagcacgtac gggcggcggc     1140

ggcggatccg atgatgagta catgctggct gacagcatct caggagacga cctgggcagt     1200

ggggatctcg gatcaggcga catctag                                         1227


<210>  39
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 1 in P61Fc-HS

<400>  39
gcagca                                                                   6


<210>  40
<211>  231
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2-1 portion in P61Fc-HS

<400>  40
gctgctcagt ccaccattga ggaacaggcc aagacatttt tggacaagtt taaccacgaa       60

gccgaagacc tgttctatca aagttcactt gcttcttgga attataacac caatattact      120

gaagagaatg tccaaaacat gaataatgct ggggacaaat ggtctgcctt tttaaaggaa      180

cagtccacac ttgcccaaat gtatccacta caagaaattc agaatctcac a               231


<210>  41
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 2 in P61Fc-HS

<400>  41
ggaggagga                                                                9


<210>  42
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2-2 portion in P61Fc-HS

<400>  42
caaggattct gggaaaattc catgctaacg gacccaggaa atgttcagaa agcagtctgc       60

catcccacag cttgggacct ggggaagggc gacttcagg                              99


<210>  43
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 3 in P61Fc-HS

<400>  43
gggccctcgg gctcgagtgc tgagcccaaa tcttgtgaca aaactcacac atgcccaccg       60

tgcccagca                                                               69


<210>  44
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker 4 in P61Fc-HS

<400>  44
gcacgtacgg gcggcggcgg cggatcc                                           27


<210>  45
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of P61Fc-HS

<400>  45

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Ala Ala Ala Gln Ser Thr Ile Glu Glu Gln Ala 
            20                  25                  30          


Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr 
        35                  40                  45              


Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu 
    50                  55                  60                  


Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu 
65                  70                  75                  80  


Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln 
                85                  90                  95      


Asn Leu Thr Gly Gly Gly Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
            100                 105                 110         


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
        115                 120                 125             


Leu Gly Lys Gly Asp Phe Arg Gly Pro Ser Gly Ser Ser Ala Glu Pro 
    130                 135                 140                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
145                 150                 155                 160 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Ala Arg Thr Gly Gly Gly Gly Gly Ser Asp 
    370                 375                 380                 


Asp Glu Tyr Met Leu Ala Asp Ser Ile Ser Gly Asp Asp Leu Gly Ser 
385                 390                 395                 400 


Gly Asp Leu Gly Ser Gly Asp Ile 
                405             


<210>  46
<211>  3369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc-SA DNA sequence

<400>  46
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggctcgaggg ctgctcagtc caccattgag gaacaggcca agacattttt ggacaagttt      120

aaccacgaag ccgaagacct gttctatcaa agttcacttg cttcttggaa ttataacacc      180

aatattactg aagagaatgt ccaaaacatg aataatgctg gggacaaatg gtctgccttt      240

ttaaaggaac agtccacact tgcccaaatg tatccactac aagaaattca gaatctcaca      300

gtcaagcttc agctgcaggc tcttcagcaa aatgggtctt cagtgctctc agaagacaag      360

agcaaacggt tgaacacaat tctaaataca atgagcacca tctacagtac tggaaaagtt      420

tgtaacccag ataatccaca agaatgctta ttacttgaac caggtttgaa tgaaataatg      480

gcaaacagtt tagactacaa tgagaggctc tgggcttggg aaagctggag atctgaggtc      540

ggcaagcagc tgaggccatt atatgaagag tatgtggtct tgaaaaatga gatggcaaga      600

gcaaatcatt atgaggacta tggggattat tggagaggag actatgaagt aaatggggta      660

gatggctatg actacagccg cggccagttg attgaagatg tggaacatac ctttgaagag      720

attaaaccat tatatgaaca tcttcatgcc tatgtgaggg caaagttgat gaatgcctat      780

ccttcctata tcagtccaat tggatgcctc cctgctcatt tgcttggtga tatgtggggt      840

agattttgga caaatctgta ctctttgaca gttccctttg gacagaaacc aaacatagat      900

gttactgatg caatggtgga ccaggcctgg gatgcacaga gaatattcaa ggaggccgag      960

aagttctttg tatctgttgg tcttcctaat atgactcaag gattctggga aaattccatg     1020

ctaacggacc caggaaatgt tcagaaagca gtctgccatc ccacagcttg ggacctgggg     1080

aagggcgact tcaggatcct tatgtgcaca aaggtgacaa tggacgactt cctgacagct     1140

catcatgaga tggggcatat ccagtatgat atggcatatg ctgcacaacc ttttctgcta     1200

agaaatggag ctaatgaagg attccatgaa gctgttgggg aaatcatgtc actttctgca     1260

gccacaccta agcatttaaa atccattggt cttctgtcac ccgattttca agaagacaat     1320

gaaacagaaa taaacttcct gctcaaacaa gcactcacga ttgttgggac tctgccattt     1380

acttacatgt tagagaagtg gaggtggatg gtctttaaag gggaaattcc caaagaccag     1440

tggatgaaaa agtggtggga gatgaagcga gagatagttg gggtggtgga acctgtgccc     1500

catgatgaaa catactgtga ccccgcatct ctgttccatg tttctaatga ttactcattc     1560

attcgatatt acacaaggac cctttaccaa ttccagtttc aagaagcact ttgtcaagca     1620

gctaaacatg aaggccctct gcacaaatgt gacatctcaa actctacaga agctggacag     1680

aaactgttca atatgctgag gcttggaaaa tcagaaccct ggaccctagc attggaaaat     1740

gttgtaggag caaagaacat gaatgtaagg ccactgctca actactttga gcccttattt     1800

acctggctga aagaccagaa caagaattct tttgtgggat ggagtaccga ctggagtcca     1860

tatgcagacc aaagcatcaa agtgaggata agcctaaaat cagctcttgg agataaagca     1920

tatgaatgga acgacaatga aatgtacctg ttccgatcat ctgttgcata tgctatgagg     1980

cagtactttt taaaagtaaa aaatcagatg attctttttg gggaggagga tgtgcgagtg     2040

gctaatttga aaccaagaat ctcctttaat ttctttgtca ctgcacctaa aaatgtgtct     2100

gatatcattc ctagaactga agttgaaaag gccatcagga tgtcccggag ccgtatcaat     2160

gatgctttcc gtctgaatga caacagccta gagtttctgg ggatacagcc aacacttgga     2220

cctcctaacc agccccctgt ttccgggccc tcgggctcga gtgctgagcc caaatcttgt     2280

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     2340

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     2400

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2460

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2520

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2580

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2640

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     2700

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2760

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2820

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2880

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2940

ctctccctgt ctccgggtaa agcacgtacg ggcggcggcg gcggatccga agctggcata     3000

acaggcacgt ggtacaatca actcgggagc acgtttattg tgacagcagg agcggatgga     3060

gcactgacgg ggacttacga gagtgctgtg ggtaacgccg agtctcgata tgtactgaca     3120

ggcagatacg atagcgcacc ggccaccgac ggttcaggaa cggccctggg ctggaccgtt     3180

gcttggaaga ataactacag gaacgcacac agtgcaacta catggtctgg ccagtacgtg     3240

gggggagcgg aagccaggat aaacacgcag tggctcctta ctagcggaac cacagaagcg     3300

aacgcatgga aatctacact ggtggggcat gacacgttta cgaaggtaaa accctctgcg     3360

gctagttag                                                             3369


<210>  47
<211>  1122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc-SA amino acid sequence

<400>  47

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Arg Ala Ala Gln Ser Thr Ile Glu Glu Gln 
            20                  25                  30          


Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe 
        35                  40                  45              


Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu 
    50                  55                  60                  


Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe 
65                  70                  75                  80  


Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile 
                85                  90                  95      


Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly 
            100                 105                 110         


Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu 
        115                 120                 125             


Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp 
    130                 135                 140                 


Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met 
145                 150                 155                 160 


Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp 
                165                 170                 175     


Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val 
            180                 185                 190         


Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly 
        195                 200                 205             


Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp 
    210                 215                 220                 


Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu 
225                 230                 235                 240 


Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu 
                245                 250                 255     


Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala 
            260                 265                 270         


His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser 
        275                 280                 285             


Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala 
    290                 295                 300                 


Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu 
305                 310                 315                 320 


Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp 
                325                 330                 335     


Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys 
            340                 345                 350         


His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met 
        355                 360                 365             


Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met 
    370                 375                 380                 


Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu 
385                 390                 395                 400 


Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met 
                405                 410                 415     


Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu 
            420                 425                 430         


Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu 
        435                 440                 445             


Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu 
    450                 455                 460                 


Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln 
465                 470                 475                 480 


Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val 
                485                 490                 495     


Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe 
            500                 505                 510         


His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu 
        515                 520                 525             


Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu 
    530                 535                 540                 


Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln 
545                 550                 555                 560 


Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu 
                565                 570                 575     


Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu 
            580                 585                 590         


Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys 
        595                 600                 605             


Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln 
    610                 615                 620                 


Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala 
625                 630                 635                 640 


Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala 
                645                 650                 655     


Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu 
            660                 665                 670         


Phe Gly Glu Glu Asp Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser 
        675                 680                 685             


Phe Asn Phe Phe Val Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro 
    690                 695                 700                 


Arg Thr Glu Val Glu Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn 
705                 710                 715                 720 


Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln 
                725                 730                 735     


Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro Val Ser Gly Pro Ser Gly 
            740                 745                 750         


Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Arg Thr Gly Gly 
            980                 985                 990         


Gly Gly Gly Ser Glu Ala Gly Ile  Thr Gly Thr Trp Tyr  Asn Gln Leu 
        995                 1000                 1005             


Gly Ser  Thr Phe Ile Val Thr  Ala Gly Ala Asp Gly  Ala Leu Thr 
    1010                 1015                 1020             


Gly Thr  Tyr Glu Ser Ala Val  Gly Asn Ala Glu Ser  Arg Tyr Val 
    1025                 1030                 1035             


Leu Thr  Gly Arg Tyr Asp Ser  Ala Pro Ala Thr Asp  Gly Ser Gly 
    1040                 1045                 1050             


Thr Ala  Leu Gly Trp Thr Val  Ala Trp Lys Asn Asn  Tyr Arg Asn 
    1055                 1060                 1065             


Ala His  Ser Ala Thr Thr Trp  Ser Gly Gln Tyr Val  Gly Gly Ala 
    1070                 1075                 1080             


Glu Ala  Arg Ile Asn Thr Gln  Trp Leu Leu Thr Ser  Gly Thr Thr 
    1085                 1090                 1095             


Glu Ala  Asn Ala Trp Lys Ser  Thr Leu Val Gly His  Asp Thr Phe 
    1100                 1105                 1110             


Thr Lys  Val Lys Pro Ser Ala  Ala Ser 
    1115                 1120         


<210>  48
<211>  3036
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc-AviTag DNA sequence

<400>  48
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggctcgaggg ctgctcagtc caccattgag gaacaggcca agacattttt ggacaagttt      120

aaccacgaag ccgaagacct gttctatcaa agttcacttg cttcttggaa ttataacacc      180

aatattactg aagagaatgt ccaaaacatg aataatgctg gggacaaatg gtctgccttt      240

ttaaaggaac agtccacact tgcccaaatg tatccactac aagaaattca gaatctcaca      300

gtcaagcttc agctgcaggc tcttcagcaa aatgggtctt cagtgctctc agaagacaag      360

agcaaacggt tgaacacaat tctaaataca atgagcacca tctacagtac tggaaaagtt      420

tgtaacccag ataatccaca agaatgctta ttacttgaac caggtttgaa tgaaataatg      480

gcaaacagtt tagactacaa tgagaggctc tgggcttggg aaagctggag atctgaggtc      540

ggcaagcagc tgaggccatt atatgaagag tatgtggtct tgaaaaatga gatggcaaga      600

gcaaatcatt atgaggacta tggggattat tggagaggag actatgaagt aaatggggta      660

gatggctatg actacagccg cggccagttg attgaagatg tggaacatac ctttgaagag      720

attaaaccat tatatgaaca tcttcatgcc tatgtgaggg caaagttgat gaatgcctat      780

ccttcctata tcagtccaat tggatgcctc cctgctcatt tgcttggtga tatgtggggt      840

agattttgga caaatctgta ctctttgaca gttccctttg gacagaaacc aaacatagat      900

gttactgatg caatggtgga ccaggcctgg gatgcacaga gaatattcaa ggaggccgag      960

aagttctttg tatctgttgg tcttcctaat atgactcaag gattctggga aaattccatg     1020

ctaacggacc caggaaatgt tcagaaagca gtctgccatc ccacagcttg ggacctgggg     1080

aagggcgact tcaggatcct tatgtgcaca aaggtgacaa tggacgactt cctgacagct     1140

catcatgaga tggggcatat ccagtatgat atggcatatg ctgcacaacc ttttctgcta     1200

agaaatggag ctaatgaagg attccatgaa gctgttgggg aaatcatgtc actttctgca     1260

gccacaccta agcatttaaa atccattggt cttctgtcac ccgattttca agaagacaat     1320

gaaacagaaa taaacttcct gctcaaacaa gcactcacga ttgttgggac tctgccattt     1380

acttacatgt tagagaagtg gaggtggatg gtctttaaag gggaaattcc caaagaccag     1440

tggatgaaaa agtggtggga gatgaagcga gagatagttg gggtggtgga acctgtgccc     1500

catgatgaaa catactgtga ccccgcatct ctgttccatg tttctaatga ttactcattc     1560

attcgatatt acacaaggac cctttaccaa ttccagtttc aagaagcact ttgtcaagca     1620

gctaaacatg aaggccctct gcacaaatgt gacatctcaa actctacaga agctggacag     1680

aaactgttca atatgctgag gcttggaaaa tcagaaccct ggaccctagc attggaaaat     1740

gttgtaggag caaagaacat gaatgtaagg ccactgctca actactttga gcccttattt     1800

acctggctga aagaccagaa caagaattct tttgtgggat ggagtaccga ctggagtcca     1860

tatgcagacc aaagcatcaa agtgaggata agcctaaaat cagctcttgg agataaagca     1920

tatgaatgga acgacaatga aatgtacctg ttccgatcat ctgttgcata tgctatgagg     1980

cagtactttt taaaagtaaa aaatcagatg attctttttg gggaggagga tgtgcgagtg     2040

gctaatttga aaccaagaat ctcctttaat ttctttgtca ctgcacctaa aaatgtgtct     2100

gatatcattc ctagaactga agttgaaaag gccatcagga tgtcccggag ccgtatcaat     2160

gatgctttcc gtctgaatga caacagccta gagtttctgg ggatacagcc aacacttgga     2220

cctcctaacc agccccctgt ttccgggccc tcgggctcga gtgctgagcc caaatcttgt     2280

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     2340

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     2400

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2460

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2520

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2580

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2640

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     2700

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2760

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2820

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2880

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2940

ctctccctgt ctccgggtaa agcacgtacg ggcggcggcg gcggatccgg gctgaatgat     3000

attttcgaag cacagaaaat tgaatggcat gagtag                               3036


<210>  49
<211>  1011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc-AviTag amino acid sequence

<400>  49

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Arg Ala Ala Gln Ser Thr Ile Glu Glu Gln 
            20                  25                  30          


Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe 
        35                  40                  45              


Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu 
    50                  55                  60                  


Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe 
65                  70                  75                  80  


Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile 
                85                  90                  95      


Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly 
            100                 105                 110         


Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu 
        115                 120                 125             


Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp 
    130                 135                 140                 


Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met 
145                 150                 155                 160 


Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp 
                165                 170                 175     


Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val 
            180                 185                 190         


Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly 
        195                 200                 205             


Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp 
    210                 215                 220                 


Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu 
225                 230                 235                 240 


Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu 
                245                 250                 255     


Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala 
            260                 265                 270         


His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser 
        275                 280                 285             


Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala 
    290                 295                 300                 


Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu 
305                 310                 315                 320 


Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp 
                325                 330                 335     


Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys 
            340                 345                 350         


His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met 
        355                 360                 365             


Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met 
    370                 375                 380                 


Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu 
385                 390                 395                 400 


Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met 
                405                 410                 415     


Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu 
            420                 425                 430         


Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu 
        435                 440                 445             


Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu 
    450                 455                 460                 


Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln 
465                 470                 475                 480 


Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val 
                485                 490                 495     


Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe 
            500                 505                 510         


His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu 
        515                 520                 525             


Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu 
    530                 535                 540                 


Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln 
545                 550                 555                 560 


Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu 
                565                 570                 575     


Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu 
            580                 585                 590         


Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys 
        595                 600                 605             


Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln 
    610                 615                 620                 


Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala 
625                 630                 635                 640 


Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala 
                645                 650                 655     


Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu 
            660                 665                 670         


Phe Gly Glu Glu Asp Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser 
        675                 680                 685             


Phe Asn Phe Phe Val Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro 
    690                 695                 700                 


Arg Thr Glu Val Glu Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn 
705                 710                 715                 720 


Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln 
                725                 730                 735     


Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro Val Ser Gly Pro Ser Gly 
            740                 745                 750         


Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Arg Thr Gly Gly 
            980                 985                 990         


Gly Gly Gly Ser Gly Leu Asn Asp  Ile Phe Glu Ala Gln  Lys Ile Glu 
        995                 1000                 1005             


Trp His  Glu 
    1010     


<210>  50
<211>  2994
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc-Strep-Tag II DNA sequence

<400>  50
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggctcgaggg ctgctcagtc caccattgag gaacaggcca agacattttt ggacaagttt      120

aaccacgaag ccgaagacct gttctatcaa agttcacttg cttcttggaa ttataacacc      180

aatattactg aagagaatgt ccaaaacatg aataatgctg gggacaaatg gtctgccttt      240

ttaaaggaac agtccacact tgcccaaatg tatccactac aagaaattca gaatctcaca      300

gtcaagcttc agctgcaggc tcttcagcaa aatgggtctt cagtgctctc agaagacaag      360

agcaaacggt tgaacacaat tctaaataca atgagcacca tctacagtac tggaaaagtt      420

tgtaacccag ataatccaca agaatgctta ttacttgaac caggtttgaa tgaaataatg      480

gcaaacagtt tagactacaa tgagaggctc tgggcttggg aaagctggag atctgaggtc      540

ggcaagcagc tgaggccatt atatgaagag tatgtggtct tgaaaaatga gatggcaaga      600

gcaaatcatt atgaggacta tggggattat tggagaggag actatgaagt aaatggggta      660

gatggctatg actacagccg cggccagttg attgaagatg tggaacatac ctttgaagag      720

attaaaccat tatatgaaca tcttcatgcc tatgtgaggg caaagttgat gaatgcctat      780

ccttcctata tcagtccaat tggatgcctc cctgctcatt tgcttggtga tatgtggggt      840

agattttgga caaatctgta ctctttgaca gttccctttg gacagaaacc aaacatagat      900

gttactgatg caatggtgga ccaggcctgg gatgcacaga gaatattcaa ggaggccgag      960

aagttctttg tatctgttgg tcttcctaat atgactcaag gattctggga aaattccatg     1020

ctaacggacc caggaaatgt tcagaaagca gtctgccatc ccacagcttg ggacctgggg     1080

aagggcgact tcaggatcct tatgtgcaca aaggtgacaa tggacgactt cctgacagct     1140

catcatgaga tggggcatat ccagtatgat atggcatatg ctgcacaacc ttttctgcta     1200

agaaatggag ctaatgaagg attccatgaa gctgttgggg aaatcatgtc actttctgca     1260

gccacaccta agcatttaaa atccattggt cttctgtcac ccgattttca agaagacaat     1320

gaaacagaaa taaacttcct gctcaaacaa gcactcacga ttgttgggac tctgccattt     1380

acttacatgt tagagaagtg gaggtggatg gtctttaaag gggaaattcc caaagaccag     1440

tggatgaaaa agtggtggga gatgaagcga gagatagttg gggtggtgga acctgtgccc     1500

catgatgaaa catactgtga ccccgcatct ctgttccatg tttctaatga ttactcattc     1560

attcgatatt acacaaggac cctttaccaa ttccagtttc aagaagcact ttgtcaagca     1620

gctaaacatg aaggccctct gcacaaatgt gacatctcaa actctacaga agctggacag     1680

aaactgttca atatgctgag gcttggaaaa tcagaaccct ggaccctagc attggaaaat     1740

gttgtaggag caaagaacat gaatgtaagg ccactgctca actactttga gcccttattt     1800

acctggctga aagaccagaa caagaattct tttgtgggat ggagtaccga ctggagtcca     1860

tatgcagacc aaagcatcaa agtgaggata agcctaaaat cagctcttgg agataaagca     1920

tatgaatgga acgacaatga aatgtacctg ttccgatcat ctgttgcata tgctatgagg     1980

cagtactttt taaaagtaaa aaatcagatg attctttttg gggaggagga tgtgcgagtg     2040

gctaatttga aaccaagaat ctcctttaat ttctttgtca ctgcacctaa aaatgtgtct     2100

gatatcattc ctagaactga agttgaaaag gccatcagga tgtcccggag ccgtatcaat     2160

gatgctttcc gtctgaatga caacagccta gagtttctgg ggatacagcc aacacttgga     2220

cctcctaacc agccccctgt ttccgggccc tcgggctcga gtgctgagcc caaatcttgt     2280

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     2340

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     2400

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2460

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2520

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2580

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2640

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     2700

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2760

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2820

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2880

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2940

ctctccctgt ctccgggtaa agccgcctgg agtcatccac aattcgaaaa gtag           2994


<210>  51
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2-Fc-Strep-Tag II amino acid sequence

<400>  51

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Arg Ala Ala Gln Ser Thr Ile Glu Glu Gln 
            20                  25                  30          


Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe 
        35                  40                  45              


Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu 
    50                  55                  60                  


Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe 
65                  70                  75                  80  


Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile 
                85                  90                  95      


Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly 
            100                 105                 110         


Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu 
        115                 120                 125             


Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp 
    130                 135                 140                 


Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met 
145                 150                 155                 160 


Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp 
                165                 170                 175     


Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val 
            180                 185                 190         


Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly 
        195                 200                 205             


Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp 
    210                 215                 220                 


Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu 
225                 230                 235                 240 


Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu 
                245                 250                 255     


Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala 
            260                 265                 270         


His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser 
        275                 280                 285             


Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala 
    290                 295                 300                 


Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu 
305                 310                 315                 320 


Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp 
                325                 330                 335     


Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys 
            340                 345                 350         


His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met 
        355                 360                 365             


Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met 
    370                 375                 380                 


Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu 
385                 390                 395                 400 


Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met 
                405                 410                 415     


Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu 
            420                 425                 430         


Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu 
        435                 440                 445             


Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu 
    450                 455                 460                 


Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln 
465                 470                 475                 480 


Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val 
                485                 490                 495     


Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe 
            500                 505                 510         


His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu 
        515                 520                 525             


Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu 
    530                 535                 540                 


Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln 
545                 550                 555                 560 


Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu 
                565                 570                 575     


Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu 
            580                 585                 590         


Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys 
        595                 600                 605             


Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln 
    610                 615                 620                 


Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala 
625                 630                 635                 640 


Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala 
                645                 650                 655     


Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu 
            660                 665                 670         


Phe Gly Glu Glu Asp Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser 
        675                 680                 685             


Phe Asn Phe Phe Val Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro 
    690                 695                 700                 


Arg Thr Glu Val Glu Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn 
705                 710                 715                 720 


Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln 
                725                 730                 735     


Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro Val Ser Gly Pro Ser Gly 
            740                 745                 750         


Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Trp Ser His 
            980                 985                 990         


Pro Gln Phe Glu Lys 
        995         


