                         SEQUENCE LISTING

<110>  INNATE PHARMA
 
<120>  TREATMENT OF CANCER

<130>  NECTIN-4-1

<150>  US 62/968,175
<151>  2020-01-31

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  510
<212>  PRT
<213>  homo sapiens

<400>  1

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  2
<211>  113
<212>  PRT
<213>  homo sapiens

<400>  2

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg 
    


<210>  3
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110     


<210>  5
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  6
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  115
<212>  PRT
<213>  mus musculus

<400>  7

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Asp Val Thr Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  8
<211>  111
<212>  PRT
<213>  mus musculus

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ile Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Asn Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Arg Phe Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ser Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Leu Ile His Ala Met Asp Asn Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Asn Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  11
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu Glu Gly Gln 
1               5                   10                  15      


Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser Ser Arg Ser 
        35                  40                  45              


Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe His Leu Val 
    50                  55                  60                  


Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val Ser His 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr 
                85                  90  


<210>  12
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Ser Val Arg Gly Leu Glu Asp Gln Asn Leu Trp His Ile Gly Arg 
1               5                   10                  15      


Glu Gly Ala Met Leu Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser 
            20                  25                  30          


Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu Pro Ser Gly Val Arg Val 
        35                  40                  45              


Asp Gly Asp Thr Leu Gly Phe Pro Pro Leu Thr Thr Glu His Ser Gly 
    50                  55                  60                  


Ile Tyr Val Cys His Val Ser Asn Glu Phe Ser Ser Arg Asp Ser Gln 
65                  70                  75                  80  


Val Thr Val Asp Val Leu Asp Pro Gln Glu Asp Ser Gly Lys Gln Val 
                85                  90                  95      


Asp Leu Val Ser Ala Ser Val 
            100             


<210>  13
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  14
<211>  479
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu 
        115                 120                 125             


Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly 
    130                 135                 140                 


Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr 
145                 150                 155                 160 


Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu 
                165                 170                 175     


Phe His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys 
            180                 185                 190         


Val Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile 
        195                 200                 205             


Leu His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp 
    210                 215                 220                 


Gln Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu 
225                 230                 235                 240 


Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly 
                245                 250                 255     


Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro 
            260                 265                 270         


Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn 
        275                 280                 285             


Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro 
    290                 295                 300                 


Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val 
305                 310                 315                 320 


Val Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val 
                325                 330                 335     


Val Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr 
            340                 345                 350         


Gln Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg 
        355                 360                 365             


Arg Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser 
    370                 375                 380                 


Val Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser 
385                 390                 395                 400 


Ser Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr 
                405                 410                 415     


Leu Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro 
            420                 425                 430         


Gly Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys 
        435                 440                 445             


Gln Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys 
    450                 455                 460                 


Pro Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
465                 470                 475                 


<210>  15
<211>  363
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu Glu Gly Gln 
1               5                   10                  15      


Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser Ser Arg Ser 
        35                  40                  45              


Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe His Leu Val 
    50                  55                  60                  


Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val Ser His 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu His Val Ser 
                85                  90                  95      


Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln Asn Leu Trp 
            100                 105                 110         


His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser Glu Gly Gln 
        115                 120                 125             


Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu Pro Ser 
    130                 135                 140                 


Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro Leu Thr Thr 
145                 150                 155                 160 


Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu Phe Ser Ser 
                165                 170                 175     


Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln Glu Asp Ser 
            180                 185                 190         


Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val Val Gly Val 
        195                 200                 205             


Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val Val Leu Met 
    210                 215                 220                 


Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr Glu 
225                 230                 235                 240 


Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His Ser 
                245                 250                 255     


His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu Arg 
            260                 265                 270         


Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser Val 
        275                 280                 285             


Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr Val 
    290                 295                 300                 


Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly Arg 
305                 310                 315                 320 


Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln Ala Met Asn 
                325                 330                 335     


His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly Asn 
            340                 345                 350         


Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
        355                 360             


<210>  16
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Ala Ser Val Arg Gly Leu Glu Asp Gln Asn Leu Trp His Ile Gly Arg 
1               5                   10                  15      


Glu Gly Ala Met Leu Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser 
            20                  25                  30          


Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu Pro Ser Gly Val Arg Val 
        35                  40                  45              


Asp Gly Asp Thr Leu Gly Phe Pro Pro Leu Thr Thr Glu His Ser Gly 
    50                  55                  60                  


Ile Tyr Val Cys His Val Ser Asn Glu Phe Ser Ser Arg Asp Ser Gln 
65                  70                  75                  80  


Val Thr Val Asp Val Leu Asp Pro Gln Glu Asp Ser Gly Lys Gln Val 
                85                  90                  95      


Asp Leu Val Ser Ala Ser Val Val Val Val Gly Val Ile Ala Ala Leu 
            100                 105                 110         


Leu Phe Cys Leu Leu Val Val Val Val Val Leu Met Ser Arg Tyr His 
        115                 120                 125             


Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr Glu Glu Glu Leu Thr 
    130                 135                 140                 


Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His Ser His His Thr Asp 
145                 150                 155                 160 


Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu Arg Ala Glu Gly His 
                165                 170                 175     


Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser Val Met Ser Glu Glu 
            180                 185                 190         


Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr Val Arg Glu Ile Glu 
        195                 200                 205             


Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly Arg Ala Glu Glu Glu 
    210                 215                 220                 


Glu Asp Gln Asp Glu Gly Ile Lys Gln Ala Met Asn His Phe Val Gln 
225                 230                 235                 240 


Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly Asn Gly Ile Tyr Ile 
                245                 250                 255     


Asn Gly Arg Gly His Leu Val 
            260             


