                         SEQUENCE LISTING

<110>  Université de Strasbourg et al
 
<120>  ANTISENSE OLIGONUCLEOTIDE TARGETING LINC00518 FOR TREATING 
       MELANOMA

<130>  B3198PC

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  999
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LINC000518 ISOFORM 1

<400>  1
taagagtggg gccctagtct gataggactg gtgtccttac aagaagaggg agagtcctca       60

gagagtcctc tctctcggca tggacacaaa agaaaagcca tgtgaggaca cagagagaag      120

gtggctgtct acgagctagg aagaaaggcc tcaccggaaa ccaaccctca cagcagctcc      180

atcttggact tccagcctcc ggaactgtga gaaaataaat gtttgcaatt caggctcaga      240

gccactcaga cattgggaag caagtttgtc aagatgacag agaaccgagg taatggattc      300

gagtgatgaa acaggaagtt cattcatgag tttttggcca cacctccaaa gtgacgactt      360

agccagaaat gggataactg ggtttcccta cttctctttt atcatcctca atgagagtga      420

ccaaatatta gagctagatg gaaccttagt gaaaatctgg ctactcgtcc cgtcccacca      480

gcctgccacc catttcaagt ttgaagagac aaagacacat ggaccttatg taattactgg      540

ggattacccc aggagtctgt ggcaaaagtc agcttcttcc ctccctgctt ccccgccctg      600

tctctggtac tttctaccaa cactgggctg tttctgtgat cacacttaag cgtacctaac      660

ctgcgaatgc tgtatagaag gtgctaatga acatgattta gctttaacac tcagttttct      720

aaagggacac gtgggggcag caaatgttta ggcaaaaaca attccagttc tagcctctac      780

tgtctacata tgtgtataca tttgggaaac gtttgggaaa gggatatttg agagcttctt      840

tttctttttt gtggtttagt tatttgatga tattgagatt gtttctgagc catgtgcttc      900

aacatcggat tggggatttc agaaaaagtt ttagtcactg tgattccatt tagcttccaa      960

atgtgtctct gctaagagac ttaaaagcac tcataaata                             999


<210>  2
<211>  906
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LINC000518 ISOFORM 2

<400>  2
caagaagagg gagagtcctc agagagtcct ctctctcggc atggacacaa aagaaaagcc       60

atgtgaggac acagagagaa ggtggctgtc tacgagctag gaagaaaggc ctcaccggaa      120

accaaccctc acagcagctc catcttggac ttccagcctc cggaactgtg agaaaataaa      180

tgtttgcaat tcagggagct ccacccagca gcagcgtttg acagagctgt tcacttcctc      240

ttcctggagc tgtggcttcc agagcccatg ctcagcagtt cccctccttc ttcgactgct      300

cctctcttag gctcagagcc actcagacat tgggaagcaa gtttgtcaag atgacagaga      360

accgaggtaa tggattcgag tgatgaaaca ggaagttcat tcatgagttt ttggccacac      420

ctccaaagtg acgacttagc cagaaatggg ataactgggt ttccctactt ctcttttatc      480

atcctcaatg agagtgacca aatattagag ctagatggaa ccttagtgaa aatctggcta      540

ctcgtcccgt cccaccagcc tgccacccat ttcaagtttg aagagacaaa gacacatgga      600

ccttatgtaa ttactgggga ttaccccagg agtctgtggc aaaagtcagc ttcttccctc      660

cctgcttccc cgccctgtct ctggtacttt ctaccaacac tgggctgttt ctgtgatcac      720

acttaagcgt acctaacctg cgaatgctgt atagaaggtg ctaatgaaca tgatttagct      780

ttaacactca gttttctaaa gggacacgtg ggggcagcaa atgtttaggc aaaaacaatt      840

ccagttctag cctctactgt ctacatatgt gtatacattt gggaaacgtt tgggaaaggg      900

atattt                                                                 906


<210>  3
<211>  1548
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LINC00518 ISOFORM 3

<400>  3
agtcctcaga gagtcctctc tctcggcatg gacacaaaag aaaagccatg tgaggacaca       60

gagagaaggt ggctgtctac gagctaggaa gaaaggcctc accggaaacc aaccctcaca      120

gcagctccat cttggacttc cagcctccgg aactgtgaga aaataaatgt ttgcaattca      180

ggtcggttgt attttgtgaa ggccatccta gcaaatgaat actcctaaca ttgtctcttt      240

aagagctcac cagcctgagg taggaatcat tccatctgtg ttactaatga gaccgctgag      300

gatcaaaggg gttttccacc acatccactc acctctacat ggcgaaaacc aagggttcac      360

tctctgtctt cagggagctc cacccagcag cagcgtttga cagagctgtt cacttcctct      420

tcctggagct gtggcttcca gagcccatgc tcagcagttc ccctccttct tcgactgctc      480

ctctcttagg ctcagagcca ctcagacatt gggaagcaag tttgtcaaga tgacagagaa      540

ccgaggtaat ggattcgagt gatgaaacag gaagttcatt catgagtttt tggccacacc      600

tccaaagtga cgacttagcc agaaatggga taactgggtt tccctacttc tcttttatca      660

tcctcaatga gagtgaccaa atattagagc tagatggaac cttagtgaaa atctggctac      720

tcgtcccgtc ccaccagcct gccacccatt tcaagtttga agagacaaag acacatggac      780

cttatgtaat tactggggat taccccagga gtctgtggca aaagtcagct tcttccctcc      840

ctgcttcccc gccctgtctc tggtactttc taccaacact gggctgtttc tgtgatcaca      900

cttaagcgta cctaacctgc gaatgctgta tagaaggtgc taatgaacat gatttagctt      960

taacactcag ttttctaaag ggacacgtgg gggcagcaaa tgtttaggca aaaacaattc     1020

cagttctagc ctctactgtc tacatatgtg tatacatttg ggaaacgttt gggaaaggga     1080

tatttgagag cttctttttc ttttttgtgg tttagttatt tgatgatatt gagattgttt     1140

ctgagccatg tgcttcaaca tcggattggg gatttcagaa aaagttttag tcactgtgat     1200

tccatttagc ttccaaatgt gtctctgcta agagacttaa aagcactcat aaatagcacg     1260

tgtgtcttct ttgcagtgtt tgctaatttt gagtcacatc tttttagaaa atcatgagat     1320

ttggtgtcac agagactgga ataaatatag tcaaacttat tggtgaagat ttcctttagc     1380

tgttttcata atccatttcc attgttatga ttattgatga ataaaacatt ttctttaggt     1440

agatacttct tttttccccc caccttgatt taatgtttcc actcttattg tcaagtttct     1500

tattactccc taataactct caataaaata atgattcctg ggagatta                  1548


<210>  4
<211>  1228
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LINC00518 ISOFORM 5

<400>  4
tcagagagtc ctctctctcg gcatggacac aaaagaaaag ccatgtgagg acacagagag       60

aaggtggctg tctacgagct aggaagaaag gcctcaccgg aaaccaaccc tcacagcagc      120

tccatcttgg acttccagcc tccggaactg tgagaaaata aatgtttgca attcaggtcg      180

gttgtatttt gtgaaggcca tcctagcaaa tgaatactcc taacattgtc tctttaagag      240

ctcaccagcc tgaggtagga atcattccat ctgtgttact aatgagaccg ctgaggatca      300

aaggggtttt ccaccacatc cactcacctc tacatggcga aaaccaaggg ttcactctct      360

gtcttcaggg agctccaccc agcagcagcg tttgacagag ctgttcactt cctcttcctg      420

gagctgtggc ttccagagcc catgctcagc agttcccctc cttcttcgac tgctcctctc      480

ttaggctcaa aacctgtaac aatgcatggc acacggaaga tgtgagaatt tgctgaataa      540

ctgaatggca ccatgttgcc tcacctaagg ataatgacta agaataggaa aaatttactg      600

tgcaaagatc agttcttaat agctgtctac atctcagaac aaaaaaaatt agatgtaaac      660

cattgcacaa aggattagat gaaatttttt tgaaaaatca gacattggag gctcagagcc      720

actcagacat tgggaagcaa gtttgtcaag atgacagaga accgaggtaa tggattcgag      780

tgatgaaaca ggaagttcat tcatgagttt ttggccacac ctccaaagtg acgacttagc      840

cagaaatggg ataactgggt ttccctactt ctcttttatc atcctcaatg agagtgacca      900

aatattagag ctagatggaa ccttagtgaa aatctggcta ctcgtcccgt cccaccagcc      960

tgccacccat ttcaagtttg aagagacaaa gacacatgga ccttatgtaa ttactgggga     1020

ttaccccagg agtctgtggc aaaagtcagc ttcttccctc cctgcttccc cgccctgtct     1080

ctggtacttt ctaccaacac tgggctgttt ctgtgatcac acttaagcgt acctaacctg     1140

cgaatgctgt atagaaggtg ctaatgaaca tgatttagct ttaacactca gttttctaaa     1200

gggacacgtg ggggcagcaa atgtttag                                        1228


<210>  5
<211>  853
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LINC00518 ISOFORM 6

<400>  5
cagtgcctag gttttatgta gtgaatttgg ctaaaatggt agagctccct gattctaacc       60

tccctgcagg ttttccacca catccactca cctctacatg gcgaaaacca agggttcact      120

ctctgtcttc agggagctcc acccagcagc agcgtttgac agagctgttc acttcctctt      180

cctggagctg tggcttccag agcccatgct cagcagttcc cctccttctt cgactgctcc      240

tctcttaggc tcagagccac tcagacattg ggaagcaagt ttgtcaagat gacagagaac      300

cgaggtaatg gattcgagtg atgaaacagg aagttcattc atgagttttt ggccacacct      360

ccaaagtgac gacttagcca gaaatgggat aactgggttt ccctacttct cttttatcat      420

cctcaatgag agtgaccaaa tattagagct agatggaacc ttagtgaaaa tctggctact      480

cgtcccgtcc caccagcctg ccacccattt caagtttgaa gagacaaaga cacatggacc      540

ttatgtaatt actggggatt accccaggag tctgtggcaa aagtcagctt cttccctccc      600

tgcttccccg ccctgtctct ggtactttct accaacactg ggctgtttct gtgatcacac      660

ttaagcgtac ctaacctgcg aatgctgtat agaaggtgct aatgaacatg atttagcttt      720

aacactcagt tttctaaagg gacacgtggg ggcagcaaat gtttaggcaa aaacaattcc      780

agttctagcc tctactgtct acatatgtgt atacatttgg gaaacgtttg ggaaagggat      840

atttgagagc ttc                                                         853


<210>  6
<211>  233
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST EXON OF ISOFORM 1

<400>  6
taagagtggg gccctagtct gataggactg gtgtccttac aagaagaggg agagtcctca       60

gagagtcctc tctctcggca tggacacaaa agaaaagcca tgtgaggaca cagagagaag      120

gtggctgtct acgagctagg aagaaaggcc tcaccggaaa ccaaccctca cagcagctcc      180

atcttggact tccagcctcc ggaactgtga gaaaataaat gtttgcaatt cag             233


<210>  7
<211>  4328
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST INTRON OF ISOFORM 1

<400>  7
gtcggttgta ttttgtgaag gccatcctag caaatgaata ctcctaacat tgtctcttta       60

agagctcacc agcctgaggt aggaatcatt ccatctgtgt tactaatgag accgctgagg      120

atcaaagggg tgagtaaatt gcttagcagt gcctaggttt tatgtagtga atttggctaa      180

aatggtagag ctccctgatt ctaacctccc tgcaggtttt ccaccacatc cactcacctc      240

tacatggcga aaaccaaggg ttcactctct gtcttcaggg agctccaccc agcagcagcg      300

tttgacagag ctgttcactt cctcttcctg gagctgtggc ttccagagcc catgctcagc      360

agttcccctc cttcttcgac tgctcctctc ttaggtgagt tttgttggtg tccttcattt      420

ccctgactct aaacattgga gacctccacg tccagtcttg ggcctcttcc ctgttcatcc      480

acaagcactc cctaggtgac ctcagccgtg cttatggttg ttggccacag cgtccaaatt      540

gactttgctg cctccacact tgtccccctg ccctgaccga gcagccaagg tgactctgtt      600

aagatacgaa gcagatcacg ccattgcttg actcaagccc ctccaaagtt tctgctctca      660

gaggaaaagc taaggtcttt tttttttttg agatggagtt tcactcttgt tgcccagact      720

gcagtgcagt ggtgtgatct tggctcactg caacctccac ttcccgggtt caagcgattc      780

tcttgcctca gcctcccaag tagctgggat tacaggtgca cgccaccacg cccggctaat      840

ttttgtattt ttagtagaga tggggtttcc ccatgttggc caggctggtc tcgaactctt      900

gacctcaggt gatccacctg cctcggcttc ccaatgtgct gggattacag gcatgagcca      960

cagtgcccag ccaagctaag gtctttataa tgtctccctt cggtaccaac agctccatcc     1020

cccaactccc ttcaattctc aatttctctt tggcgtcctc tgtagctcct ctgtccttag     1080

ctcactcatg cctaccacac aagccagcca tgcttctgcc tcagggcctt tgcactcact     1140

ggtttctctg cctggaatgt ttctctggta atgcagatgc caccatatcc ttggagacat     1200

ccttatctca actgcaaacc accctccctc tcagcactac ctaacgtctt tgtttatgtt     1260

tttccttcag cccataccat tcattatcta ccatactata tattttactt accttgttta     1320

ttttctctcc tctggaatac aaagtccaca agggcagaga tttttgtctt ttgttttcat     1380

ggttctaggc tcaaaacctg taacaatgca tggcacacgg aagatgtgag aatttgctga     1440

ataactgaat ggcaccatgt tgcctcacct aaggataatg actaagaata ggaaaaattt     1500

actgtgcaaa gatcagttct taatagctgt ctacatctca gaacaaaaaa aattagatgt     1560

aaaccattgc acaaaggatt agatgaaatt tttttgaaaa atcagacatt ggaggtaagt     1620

attgccataa gccatataag caaaacaatc aaatctctgg agacactgga aaataagatt     1680

gattgtaaat ttgctgctga cgtttaccat tgctctgcat aaatgcaaaa ggaagcgctg     1740

gccaacttct catgggtttc caagtccagg tgtctaaaat ttggcagagc tgggaggact     1800

gcttgaggcc agtggtgcaa aataagcctg ggcaacatag tgagattctg cctctaaaac     1860

aaaacaaaat aaaagacaaa acaactaatt ctgtttttta aaaaaaaaaa acacacaaca     1920

gcaaacttga ctataaagat tattgctggg cacggtggct caggcctgta atcccagcac     1980

tttgggaggc tgaggcgggt ggatcacctg aggtcaggag ctcaagacca gcctggccaa     2040

catggtgaaa ccctgtctgt actaataata caaaaaatta gccgggcatg gtggtgcatg     2100

cctgcaatcc cagctactcg ggaggatgag gcaggagaat cacttgaacc tgggaggtag     2160

aggttgcagt gagccgagac tgcgccactg cactccagcc tgggcaacaa gagcaaaact     2220

ccgtgtccaa aaaaaaaaaa aaaaaaaaag attattatat ataatcattc aaggcctgta     2280

tgactcagtt cccttagaaa aatgtcataa tttttatatt actgaatatt attggcgtta     2340

tttgtgtagc ccacttaagt gaagtcaata acatgattaa gtggcatatt atcttcatgt     2400

cagtcaaacg ttatttggat tttataagtt agggtgagat acaaataagt gaaaatactt     2460

tttctaatga ataatgatga atctaaaata ggattgactt ggctgggcat agtggctcgt     2520

gcttgtaacc ccaacacttt gggaggctga ggcagtagga ttacttgaaa ccaggagttt     2580

gagaccagcc tcggcaacaa agggagaact cttctctaat aaaaataaga ataaaaaatt     2640

agccaggtgt ggcaatgttc acctgtggtc ccagctactt gggaagctga ggcaggagga     2700

tcgttggagc acaggagttc aagactgcag ttagcggtga ctgcactcca gcctgggcaa     2760

tagagcaaga ccctgtctct aaaaaaaaaa taataataaa taggactggc tcgcatatgt     2820

atgcaactat tttgttacca gtgacagaat acatgtgatg atgttttcta gtcttgtgac     2880

tggtttctta gttgtatgtt ttatttttag aattgttgtt tccaggctgt gttgtttgga     2940

aactcagctg acagatgtat gaatctgatt ccagagtctc tgagagctgg aaagggcctc     3000

agagatggtt gggactgata ctcttgcatt acaggtcagg aaatacaacc cagagacaag     3060

atgaaacttg cccaaggaca taacagccag cctgtggcta ggctgatacc agattcctgt     3120

tcttcccatt ccagtcgcat gctactcagg aaactcatca gcattcccga atattgagtg     3180

tttcctacct gttacattag cagtttttga gaagggtata tattgtagtt aaattaatca     3240

gctttgggaa aatatgggtg cagcatggga atagagactg tcatttgaga atcattgcag     3300

aaatgacaaa accctgagaa tgaagaatgg gcctgcaata gtcctggcac tttgctcttc     3360

caccaaactg aactgtagct caaaggacaa tgacttcacg tctgtcactc taaagcctgt     3420

tctaagatca catcccctct ggctctccct agatacttct gattatagtt ggtaatcatg     3480

cccattaaat gtctttggtt tcttggtaca cagagagaag gtaaataatg ggttcatgat     3540

ttaggtaaga atacacaaat atttttcaca ctataaatct gttttctatt cagttaaata     3600

ttagaccatc tggtaatgga gaaaatgttt gaaaatccac ctagttaacc taaaagtttg     3660

catttcctgc ctttggggct ttgaattttt aagttacatg tcttcgtaga tggtgatcag     3720

gataaaacta atatctctct tagatgaatc aaaattcacc cccttgggca agggagggac     3780

ccagcctttc tttaaacatg tggttgcctg agagttgaac aaaactggaa tagggagaga     3840

atggctttgc catgctgatc atggtattgt ggagatttaa gaactagtgg ccaggcgagg     3900

tggctcacgc ctgtaatccc agcattgtga gaggccaagg caggtggatc acttgaggcc     3960

aggatttcga gaccagcccg gccaacatga tgaccctgtt tttactaaaa atacaaaaat     4020

tagccgagtg tggtggtgtg tgcctgtagt cccaactgag gcatgagact tgcttcaacc     4080

caggaggcgg gggttgcagt gagccgagat tgtgccactg cactccagcc tgggtgacag     4140

agtgagactc tgtctcaaaa aaaaaaaaaa aaaaaactag tcagagctgt tgaggtgttg     4200

aggcacctgc tactgataca cactataaac gtggaagatg attttcattt ttgtagtcat     4260

gagcaggata ctgtataatg tataattgtt ggacattaaa gaaaacaaac tccttcttgt     4320

ctccttag                                                              4328


<210>  8
<211>  766
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND EXON OF ISOFORM 1

<400>  8
gctcagagcc actcagacat tgggaagcaa gtttgtcaag atgacagaga accgaggtaa       60

tggattcgag tgatgaaaca ggaagttcat tcatgagttt ttggccacac ctccaaagtg      120

acgacttagc cagaaatggg ataactgggt ttccctactt ctcttttatc atcctcaatg      180

agagtgacca aatattagag ctagatggaa ccttagtgaa aatctggcta ctcgtcccgt      240

cccaccagcc tgccacccat ttcaagtttg aagagacaaa gacacatgga ccttatgtaa      300

ttactgggga ttaccccagg agtctgtggc aaaagtcagc ttcttccctc cctgcttccc      360

cgccctgtct ctggtacttt ctaccaacac tgggctgttt ctgtgatcac acttaagcgt      420

acctaacctg cgaatgctgt atagaaggtg ctaatgaaca tgatttagct ttaacactca      480

gttttctaaa gggacacgtg ggggcagcaa atgtttaggc aaaaacaatt ccagttctag      540

cctctactgt ctacatatgt gtatacattt gggaaacgtt tgggaaaggg atatttgaga      600

gcttcttttt cttttttgtg gtttagttat ttgatgatat tgagattgtt tctgagccat      660

gtgcttcaac atcggattgg ggatttcaga aaaagtttta gtcactgtga ttccatttag      720

cttccaaatg tgtctctgct aagagactta aaagcactca taaata                     766


<210>  9
<211>  194
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST EXON OF ISOFORM 2

<400>  9
caagaagagg gagagtcctc agagagtcct ctctctcggc atggacacaa aagaaaagcc       60

atgtgaggac acagagagaa ggtggctgtc tacgagctag gaagaaaggc ctcaccggaa      120

accaaccctc acagcagctc catcttggac ttccagcctc cggaactgtg agaaaataaa      180

tgtttgcaat tcag                                                        194


<210>  10
<211>  278
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST INTRON OF ISOFORM 2

<400>  10
gtcggttgta ttttgtgaag gccatcctag caaatgaata ctcctaacat tgtctcttta       60

agagctcacc agcctgaggt aggaatcatt ccatctgtgt tactaatgag accgctgagg      120

atcaaagggg tgagtaaatt gcttagcagt gcctaggttt tatgtagtga atttggctaa      180

aatggtagag ctccctgatt ctaacctccc tgcaggtttt ccaccacatc cactcacctc      240

tacatggcga aaaccaaggg ttcactctct gtcttcag                              278


<210>  11
<211>  116
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND EXON OF ISOFORM 2

<400>  11
ggagctccac ccagcagcag cgtttgacag agctgttcac ttcctcttcc tggagctgtg       60

gcttccagag cccatgctca gcagttcccc tccttcttcg actgctcctc tcttag          116


<210>  12
<211>  3934
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND INTRON OF ISOFORM 2

<400>  12
gtgagttttg ttggtgtcct tcatttccct gactctaaac attggagacc tccacgtcca       60

gtcttgggcc tcttccctgt tcatccacaa gcactcccta ggtgacctca gccgtgctta      120

tggttgttgg ccacagcgtc caaattgact ttgctgcctc cacacttgtc cccctgccct      180

gaccgagcag ccaaggtgac tctgttaaga tacgaagcag atcacgccat tgcttgactc      240

aagcccctcc aaagtttctg ctctcagagg aaaagctaag gtcttttttt tttttgagat      300

ggagtttcac tcttgttgcc cagactgcag tgcagtggtg tgatcttggc tcactgcaac      360

ctccacttcc cgggttcaag cgattctctt gcctcagcct cccaagtagc tgggattaca      420

ggtgcacgcc accacgcccg gctaattttt gtatttttag tagagatggg gtttccccat      480

gttggccagg ctggtctcga actcttgacc tcaggtgatc cacctgcctc ggcttcccaa      540

tgtgctggga ttacaggcat gagccacagt gcccagccaa gctaaggtct ttataatgtc      600

tcccttcggt accaacagct ccatccccca actcccttca attctcaatt tctctttggc      660

gtcctctgta gctcctctgt ccttagctca ctcatgccta ccacacaagc cagccatgct      720

tctgcctcag ggcctttgca ctcactggtt tctctgcctg gaatgtttct ctggtaatgc      780

agatgccacc atatccttgg agacatcctt atctcaactg caaaccaccc tccctctcag      840

cactacctaa cgtctttgtt tatgtttttc cttcagccca taccattcat tatctaccat      900

actatatatt ttacttacct tgtttatttt ctctcctctg gaatacaaag tccacaaggg      960

cagagatttt tgtcttttgt tttcatggtt ctaggctcaa aacctgtaac aatgcatggc     1020

acacggaaga tgtgagaatt tgctgaataa ctgaatggca ccatgttgcc tcacctaagg     1080

ataatgacta agaataggaa aaatttactg tgcaaagatc agttcttaat agctgtctac     1140

atctcagaac aaaaaaaatt agatgtaaac cattgcacaa aggattagat gaaatttttt     1200

tgaaaaatca gacattggag gtaagtattg ccataagcca tataagcaaa acaatcaaat     1260

ctctggagac actggaaaat aagattgatt gtaaatttgc tgctgacgtt taccattgct     1320

ctgcataaat gcaaaaggaa gcgctggcca acttctcatg ggtttccaag tccaggtgtc     1380

taaaatttgg cagagctggg aggactgctt gaggccagtg gtgcaaaata agcctgggca     1440

acatagtgag attctgcctc taaaacaaaa caaaataaaa gacaaaacaa ctaattctgt     1500

tttttaaaaa aaaaaaacac acaacagcaa acttgactat aaagattatt gctgggcacg     1560

gtggctcagg cctgtaatcc cagcactttg ggaggctgag gcgggtggat cacctgaggt     1620

caggagctca agaccagcct ggccaacatg gtgaaaccct gtctgtacta ataatacaaa     1680

aaattagccg ggcatggtgg tgcatgcctg caatcccagc tactcgggag gatgaggcag     1740

gagaatcact tgaacctggg aggtagaggt tgcagtgagc cgagactgcg ccactgcact     1800

ccagcctggg caacaagagc aaaactccgt gtccaaaaaa aaaaaaaaaa aaaaagatta     1860

ttatatataa tcattcaagg cctgtatgac tcagttccct tagaaaaatg tcataatttt     1920

tatattactg aatattattg gcgttatttg tgtagcccac ttaagtgaag tcaataacat     1980

gattaagtgg catattatct tcatgtcagt caaacgttat ttggatttta taagttaggg     2040

tgagatacaa ataagtgaaa atactttttc taatgaataa tgatgaatct aaaataggat     2100

tgacttggct gggcatagtg gctcgtgctt gtaaccccaa cactttggga ggctgaggca     2160

gtaggattac ttgaaaccag gagtttgaga ccagcctcgg caacaaaggg agaactcttc     2220

tctaataaaa ataagaataa aaaattagcc aggtgtggca atgttcacct gtggtcccag     2280

ctacttggga agctgaggca ggaggatcgt tggagcacag gagttcaaga ctgcagttag     2340

cggtgactgc actccagcct gggcaataga gcaagaccct gtctctaaaa aaaaaataat     2400

aataaatagg actggctcgc atatgtatgc aactattttg ttaccagtga cagaatacat     2460

gtgatgatgt tttctagtct tgtgactggt ttcttagttg tatgttttat ttttagaatt     2520

gttgtttcca ggctgtgttg tttggaaact cagctgacag atgtatgaat ctgattccag     2580

agtctctgag agctggaaag ggcctcagag atggttggga ctgatactct tgcattacag     2640

gtcaggaaat acaacccaga gacaagatga aacttgccca aggacataac agccagcctg     2700

tggctaggct gataccagat tcctgttctt cccattccag tcgcatgcta ctcaggaaac     2760

tcatcagcat tcccgaatat tgagtgtttc ctacctgtta cattagcagt ttttgagaag     2820

ggtatatatt gtagttaaat taatcagctt tgggaaaata tgggtgcagc atgggaatag     2880

agactgtcat ttgagaatca ttgcagaaat gacaaaaccc tgagaatgaa gaatgggcct     2940

gcaatagtcc tggcactttg ctcttccacc aaactgaact gtagctcaaa ggacaatgac     3000

ttcacgtctg tcactctaaa gcctgttcta agatcacatc ccctctggct ctccctagat     3060

acttctgatt atagttggta atcatgccca ttaaatgtct ttggtttctt ggtacacaga     3120

gagaaggtaa ataatgggtt catgatttag gtaagaatac acaaatattt ttcacactat     3180

aaatctgttt tctattcagt taaatattag accatctggt aatggagaaa atgtttgaaa     3240

atccacctag ttaacctaaa agtttgcatt tcctgccttt ggggctttga atttttaagt     3300

tacatgtctt cgtagatggt gatcaggata aaactaatat ctctcttaga tgaatcaaaa     3360

ttcaccccct tgggcaaggg agggacccag cctttcttta aacatgtggt tgcctgagag     3420

ttgaacaaaa ctggaatagg gagagaatgg ctttgccatg ctgatcatgg tattgtggag     3480

atttaagaac tagtggccag gcgaggtggc tcacgcctgt aatcccagca ttgtgagagg     3540

ccaaggcagg tggatcactt gaggccagga tttcgagacc agcccggcca acatgatgac     3600

cctgttttta ctaaaaatac aaaaattagc cgagtgtggt ggtgtgtgcc tgtagtccca     3660

actgaggcat gagacttgct tcaacccagg aggcgggggt tgcagtgagc cgagattgtg     3720

ccactgcact ccagcctggg tgacagagtg agactctgtc tcaaaaaaaa aaaaaaaaaa     3780

aactagtcag agctgttgag gtgttgaggc acctgctact gatacacact ataaacgtgg     3840

aagatgattt tcatttttgt agtcatgagc aggatactgt ataatgtata attgttggac     3900

attaaagaaa acaaactcct tcttgtctcc ttag                                 3934


<210>  13
<211>  596
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  3RD EXON OF ISOFORM 2

<400>  13
gctcagagcc actcagacat tgggaagcaa gtttgtcaag atgacagaga accgaggtaa       60

tggattcgag tgatgaaaca ggaagttcat tcatgagttt ttggccacac ctccaaagtg      120

acgacttagc cagaaatggg ataactgggt ttccctactt ctcttttatc atcctcaatg      180

agagtgacca aatattagag ctagatggaa ccttagtgaa aatctggcta ctcgtcccgt      240

cccaccagcc tgccacccat ttcaagtttg aagagacaaa gacacatgga ccttatgtaa      300

ttactgggga ttaccccagg agtctgtggc aaaagtcagc ttcttccctc cctgcttccc      360

cgccctgtct ctggtacttt ctaccaacac tgggctgttt ctgtgatcac acttaagcgt      420

acctaacctg cgaatgctgt atagaaggtg ctaatgaaca tgatttagct ttaacactca      480

gttttctaaa gggacacgtg ggggcagcaa atgtttaggc aaaaacaatt ccagttctag      540

cctctactgt ctacatatgt gtatacattt gggaaacgtt tgggaaaggg atattt          596


<210>  14
<211>  310
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST EXON OF ISOFORM 3

<400>  14
agtcctcaga gagtcctctc tctcggcatg gacacaaaag aaaagccatg tgaggacaca       60

gagagaaggt ggctgtctac gagctaggaa gaaaggcctc accggaaacc aaccctcaca      120

gcagctccat cttggacttc cagcctccgg aactgtgaga aaataaatgt ttgcaattca      180

ggtcggttgt attttgtgaa ggccatccta gcaaatgaat actcctaaca ttgtctcttt      240

aagagctcac cagcctgagg taggaatcat tccatctgtg ttactaatga gaccgctgag      300

gatcaaaggg                                                             310


<210>  15
<211>  86
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST INTRON OF ISOFORM 3

<400>  15
gtgagtaaat tgcttagcag tgcctaggtt ttatgtagtg aatttggcta aaatggtaga       60

gctccctgat tctaacctcc ctgcag                                            86


<210>  16
<211>  179
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND EXON OF ISOFORM 3

<400>  16
gttttccacc acatccactc acctctacat ggcgaaaacc aagggttcac tctctgtctt       60

cagggagctc cacccagcag cagcgtttga cagagctgtt cacttcctct tcctggagct      120

gtggcttcca gagcccatgc tcagcagttc ccctccttct tcgactgctc ctctcttag       179


<210>  17
<211>  3934
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND INTRON OF ISOFORM 3

<400>  17
ctaaggagac aagaaggagt ttgttttctt taatgtccaa caattataca ttatacagta       60

tcctgctcat gactacaaaa atgaaaatca tcttccacgt ttatagtgtg tatcagtagc      120

aggtgcctca acacctcaac agctctgact agtttttttt tttttttttt ttgagacaga      180

gtctcactct gtcacccagg ctggagtgca gtggcacaat ctcggctcac tgcaaccccc      240

gcctcctggg ttgaagcaag tctcatgcct cagttgggac tacaggcaca caccaccaca      300

ctcggctaat ttttgtattt ttagtaaaaa cagggtcatc atgttggccg ggctggtctc      360

gaaatcctgg cctcaagtga tccacctgcc ttggcctctc acaatgctgg gattacaggc      420

gtgagccacc tcgcctggcc actagttctt aaatctccac aataccatga tcagcatggc      480

aaagccattc tctccctatt ccagttttgt tcaactctca ggcaaccaca tgtttaaaga      540

aaggctgggt ccctcccttg cccaaggggg tgaattttga ttcatctaag agagatatta      600

gttttatcct gatcaccatc tacgaagaca tgtaacttaa aaattcaaag ccccaaaggc      660

aggaaatgca aacttttagg ttaactaggt ggattttcaa acattttctc cattaccaga      720

tggtctaata tttaactgaa tagaaaacag atttatagtg tgaaaaatat ttgtgtattc      780

ttacctaaat catgaaccca ttatttacct tctctctgtg taccaagaaa ccaaagacat      840

ttaatgggca tgattaccaa ctataatcag aagtatctag ggagagccag aggggatgtg      900

atcttagaac aggctttaga gtgacagacg tgaagtcatt gtcctttgag ctacagttca      960

gtttggtgga agagcaaagt gccaggacta ttgcaggccc attcttcatt ctcagggttt     1020

tgtcatttct gcaatgattc tcaaatgaca gtctctattc ccatgctgca cccatatttt     1080

cccaaagctg attaatttaa ctacaatata tacccttctc aaaaactgct aatgtaacag     1140

gtaggaaaca ctcaatattc gggaatgctg atgagtttcc tgagtagcat gcgactggaa     1200

tgggaagaac aggaatctgg tatcagccta gccacaggct ggctgttatg tccttgggca     1260

agtttcatct tgtctctggg ttgtatttcc tgacctgtaa tgcaagagta tcagtcccaa     1320

ccatctctga ggccctttcc agctctcaga gactctggaa tcagattcat acatctgtca     1380

gctgagtttc caaacaacac agcctggaaa caacaattct aaaaataaaa catacaacta     1440

agaaaccagt cacaagacta gaaaacatca tcacatgtat tctgtcactg gtaacaaaat     1500

agttgcatac atatgcgagc cagtcctatt tattattatt ttttttttag agacagggtc     1560

ttgctctatt gcccaggctg gagtgcagtc accgctaact gcagtcttga actcctgtgc     1620

tccaacgatc ctcctgcctc agcttcccaa gtagctggga ccacaggtga acattgccac     1680

acctggctaa ttttttattc ttatttttat tagagaagag ttctcccttt gttgccgagg     1740

ctggtctcaa actcctggtt tcaagtaatc ctactgcctc agcctcccaa agtgttgggg     1800

ttacaagcac gagccactat gcccagccaa gtcaatccta ttttagattc atcattattc     1860

attagaaaaa gtattttcac ttatttgtat ctcaccctaa cttataaaat ccaaataacg     1920

tttgactgac atgaagataa tatgccactt aatcatgtta ttgacttcac ttaagtgggc     1980

tacacaaata acgccaataa tattcagtaa tataaaaatt atgacatttt tctaagggaa     2040

ctgagtcata caggccttga atgattatat ataataatct tttttttttt tttttttttt     2100

ggacacggag ttttgctctt gttgcccagg ctggagtgca gtggcgcagt ctcggctcac     2160

tgcaacctct acctcccagg ttcaagtgat tctcctgcct catcctcccg agtagctggg     2220

attgcaggca tgcaccacca tgcccggcta attttttgta ttattagtac agacagggtt     2280

tcaccatgtt ggccaggctg gtcttgagct cctgacctca ggtgatccac ccgcctcagc     2340

ctcccaaagt gctgggatta caggcctgag ccaccgtgcc cagcaataat ctttatagtc     2400

aagtttgctg ttgtgtgttt ttttttttta aaaaacagaa ttagttgttt tgtcttttat     2460

tttgttttgt tttagaggca gaatctcact atgttgccca ggcttatttt gcaccactgg     2520

cctcaagcag tcctcccagc tctgccaaat tttagacacc tggacttgga aacccatgag     2580

aagttggcca gcgcttcctt ttgcatttat gcagagcaat ggtaaacgtc agcagcaaat     2640

ttacaatcaa tcttattttc cagtgtctcc agagatttga ttgttttgct tatatggctt     2700

atggcaatac ttacctccaa tgtctgattt ttcaaaaaaa tttcatctaa tcctttgtgc     2760

aatggtttac atctaatttt ttttgttctg agatgtagac agctattaag aactgatctt     2820

tgcacagtaa atttttccta ttcttagtca ttatccttag gtgaggcaac atggtgccat     2880

tcagttattc agcaaattct cacatcttcc gtgtgccatg cattgttaca ggttttgagc     2940

ctagaaccat gaaaacaaaa gacaaaaatc tctgcccttg tggactttgt attccagagg     3000

agagaaaata aacaaggtaa gtaaaatata tagtatggta gataatgaat ggtatgggct     3060

gaaggaaaaa cataaacaaa gacgttaggt agtgctgaga gggagggtgg tttgcagttg     3120

agataaggat gtctccaagg atatggtggc atctgcatta ccagagaaac attccaggca     3180

gagaaaccag tgagtgcaaa ggccctgagg cagaagcatg gctggcttgt gtggtaggca     3240

tgagtgagct aaggacagag gagctacaga ggacgccaaa gagaaattga gaattgaagg     3300

gagttggggg atggagctgt tggtaccgaa gggagacatt ataaagacct tagcttggct     3360

gggcactgtg gctcatgcct gtaatcccag cacattggga agccgaggca ggtggatcac     3420

ctgaggtcaa gagttcgaga ccagcctggc caacatgggg aaaccccatc tctactaaaa     3480

atacaaaaat tagccgggcg tggtggcgtg cacctgtaat cccagctact tgggaggctg     3540

aggcaagaga atcgcttgaa cccgggaagt ggaggttgca gtgagccaag atcacaccac     3600

tgcactgcag tctgggcaac aagagtgaaa ctccatctca aaaaaaaaaa agaccttagc     3660

ttttcctctg agagcagaaa ctttggaggg gcttgagtca agcaatggcg tgatctgctt     3720

cgtatcttaa cagagtcacc ttggctgctc ggtcagggca gggggacaag tgtggaggca     3780

gcaaagtcaa tttggacgct gtggccaaca accataagca cggctgaggt cacctaggga     3840

gtgcttgtgg atgaacaggg aagaggccca agactggacg tggaggtctc caatgtttag     3900

agtcagggaa atgaaggaca ccaacaaaac tcac                                 3934


<210>  18
<211>  1059
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  3RD EXON OF ISOFORM 3

<400>  18
gctcagagcc actcagacat tgggaagcaa gtttgtcaag atgacagaga accgaggtaa       60

tggattcgag tgatgaaaca ggaagttcat tcatgagttt ttggccacac ctccaaagtg      120

acgacttagc cagaaatggg ataactgggt ttccctactt ctcttttatc atcctcaatg      180

agagtgacca aatattagag ctagatggaa ccttagtgaa aatctggcta ctcgtcccgt      240

cccaccagcc tgccacccat ttcaagtttg aagagacaaa gacacatgga ccttatgtaa      300

ttactgggga ttaccccagg agtctgtggc aaaagtcagc ttcttccctc cctgcttccc      360

cgccctgtct ctggtacttt ctaccaacac tgggctgttt ctgtgatcac acttaagcgt      420

acctaacctg cgaatgctgt atagaaggtg ctaatgaaca tgatttagct ttaacactca      480

gttttctaaa gggacacgtg ggggcagcaa atgtttaggc aaaaacaatt ccagttctag      540

cctctactgt ctacatatgt gtatacattt gggaaacgtt tgggaaaggg atatttgaga      600

gcttcttttt cttttttgtg gtttagttat ttgatgatat tgagattgtt tctgagccat      660

gtgcttcaac atcggattgg ggatttcaga aaaagtttta gtcactgtga ttccatttag      720

cttccaaatg tgtctctgct aagagactta aaagcactca taaatagcac gtgtgtcttc      780

tttgcagtgt ttgctaattt tgagtcacat ctttttagaa aatcatgaga tttggtgtca      840

cagagactgg aataaatata gtcaaactta ttggtgaaga tttcctttag ctgttttcat      900

aatccatttc cattgttatg attattgatg aataaaacat tttctttagg tagatacttc      960

ttttttcccc ccaccttgat ttaatgtttc cactcttatt gtcaagtttc ttattactcc     1020

ctaataactc tcaataaaat aatgattcct gggagatta                            1059


<210>  19
<211>  305
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST EXON OF ISOFORM 5

<400>  19
tcagagagtc ctctctctcg gcatggacac aaaagaaaag ccatgtgagg acacagagag       60

aaggtggctg tctacgagct aggaagaaag gcctcaccgg aaaccaaccc tcacagcagc      120

tccatcttgg acttccagcc tccggaactg tgagaaaata aatgtttgca attcaggtcg      180

gttgtatttt gtgaaggcca tcctagcaaa tgaatactcc taacattgtc tctttaagag      240

ctcaccagcc tgaggtagga atcattccat ctgtgttact aatgagaccg ctgaggatca      300

aaggg                                                                  305


<210>  20
<211>  86
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST INTRON OF ISOFORM 5

<400>  20
gtgagtaaat tgcttagcag tgcctaggtt ttatgtagtg aatttggcta aaatggtaga       60

gctccctgat tctaacctcc ctgcag                                            86


<210>  21
<211>  179
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND EXON OF ISOFORM 5

<400>  21
gttttccacc acatccactc acctctacat ggcgaaaacc aagggttcac tctctgtctt       60

cagggagctc cacccagcag cagcgtttga cagagctgtt cacttcctct tcctggagct      120

gtggcttcca gagcccatgc tcagcagttc ccctccttct tcgactgctc ctctcttag       179


<210>  22
<211>  994
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND INTRON OF ISOFORM 5

<400>  22
gtgagttttg ttggtgtcct tcatttccct gactctaaac attggagacc tccacgtcca       60

gtcttgggcc tcttccctgt tcatccacaa gcactcccta ggtgacctca gccgtgctta      120

tggttgttgg ccacagcgtc caaattgact ttgctgcctc cacacttgtc cccctgccct      180

gaccgagcag ccaaggtgac tctgttaaga tacgaagcag atcacgccat tgcttgactc      240

aagcccctcc aaagtttctg ctctcagagg aaaagctaag gtcttttttt tttttgagat      300

ggagtttcac tcttgttgcc cagactgcag tgcagtggtg tgatcttggc tcactgcaac      360

ctccacttcc cgggttcaag cgattctctt gcctcagcct cccaagtagc tgggattaca      420

ggtgcacgcc accacgcccg gctaattttt gtatttttag tagagatggg gtttccccat      480

gttggccagg ctggtctcga actcttgacc tcaggtgatc cacctgcctc ggcttcccaa      540

tgtgctggga ttacaggcat gagccacagt gcccagccaa gctaaggtct ttataatgtc      600

tcccttcggt accaacagct ccatccccca actcccttca attctcaatt tctctttggc      660

gtcctctgta gctcctctgt ccttagctca ctcatgccta ccacacaagc cagccatgct      720

tctgcctcag ggcctttgca ctcactggtt tctctgcctg gaatgtttct ctggtaatgc      780

agatgccacc atatccttgg agacatcctt atctcaactg caaaccaccc tccctctcag      840

cactacctaa cgtctttgtt tatgtttttc cttcagccca taccattcat tatctaccat      900

actatatatt ttacttacct tgtttatttt ctctcctctg gaatacaaag tccacaaggg      960

cagagatttt tgtcttttgt tttcatggtt ctag                                  994


<210>  23
<211>  226
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  3RD EXON OF ISOFORM 5

<400>  23
gctcaaaacc tgtaacaatg catggcacac ggaagatgtg agaatttgct gaataactga       60

atggcaccat gttgcctcac ctaaggataa tgactaagaa taggaaaaat ttactgtgca      120

aagatcagtt cttaatagct gtctacatct cagaacaaaa aaaattagat gtaaaccatt      180

gcacaaagga ttagatgaaa tttttttgaa aaatcagaca ttggag                     226


<210>  24
<211>  2714
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  3RD INTRON OF ISOFORM 5

<400>  24
gtaagtattg ccataagcca tataagcaaa acaatcaaat ctctggagac actggaaaat       60

aagattgatt gtaaatttgc tgctgacgtt taccattgct ctgcataaat gcaaaaggaa      120

gcgctggcca acttctcatg ggtttccaag tccaggtgtc taaaatttgg cagagctggg      180

aggactgctt gaggccagtg gtgcaaaata agcctgggca acatagtgag attctgcctc      240

taaaacaaaa caaaataaaa gacaaaacaa ctaattctgt tttttaaaaa aaaaaaacac      300

acaacagcaa acttgactat aaagattatt gctgggcacg gtggctcagg cctgtaatcc      360

cagcactttg ggaggctgag gcgggtggat cacctgaggt caggagctca agaccagcct      420

ggccaacatg gtgaaaccct gtctgtacta ataatacaaa aaattagccg ggcatggtgg      480

tgcatgcctg caatcccagc tactcgggag gatgaggcag gagaatcact tgaacctggg      540

aggtagaggt tgcagtgagc cgagactgcg ccactgcact ccagcctggg caacaagagc      600

aaaactccgt gtccaaaaaa aaaaaaaaaa aaaaagatta ttatatataa tcattcaagg      660

cctgtatgac tcagttccct tagaaaaatg tcataatttt tatattactg aatattattg      720

gcgttatttg tgtagcccac ttaagtgaag tcaataacat gattaagtgg catattatct      780

tcatgtcagt caaacgttat ttggatttta taagttaggg tgagatacaa ataagtgaaa      840

atactttttc taatgaataa tgatgaatct aaaataggat tgacttggct gggcatagtg      900

gctcgtgctt gtaaccccaa cactttggga ggctgaggca gtaggattac ttgaaaccag      960

gagtttgaga ccagcctcgg caacaaaggg agaactcttc tctaataaaa ataagaataa     1020

aaaattagcc aggtgtggca atgttcacct gtggtcccag ctacttggga agctgaggca     1080

ggaggatcgt tggagcacag gagttcaaga ctgcagttag cggtgactgc actccagcct     1140

gggcaataga gcaagaccct gtctctaaaa aaaaaataat aataaatagg actggctcgc     1200

atatgtatgc aactattttg ttaccagtga cagaatacat gtgatgatgt tttctagtct     1260

tgtgactggt ttcttagttg tatgttttat ttttagaatt gttgtttcca ggctgtgttg     1320

tttggaaact cagctgacag atgtatgaat ctgattccag agtctctgag agctggaaag     1380

ggcctcagag atggttggga ctgatactct tgcattacag gtcaggaaat acaacccaga     1440

gacaagatga aacttgccca aggacataac agccagcctg tggctaggct gataccagat     1500

tcctgttctt cccattccag tcgcatgcta ctcaggaaac tcatcagcat tcccgaatat     1560

tgagtgtttc ctacctgtta cattagcagt ttttgagaag ggtatatatt gtagttaaat     1620

taatcagctt tgggaaaata tgggtgcagc atgggaatag agactgtcat ttgagaatca     1680

ttgcagaaat gacaaaaccc tgagaatgaa gaatgggcct gcaatagtcc tggcactttg     1740

ctcttccacc aaactgaact gtagctcaaa ggacaatgac ttcacgtctg tcactctaaa     1800

gcctgttcta agatcacatc ccctctggct ctccctagat acttctgatt atagttggta     1860

atcatgccca ttaaatgtct ttggtttctt ggtacacaga gagaaggtaa ataatgggtt     1920

catgatttag gtaagaatac acaaatattt ttcacactat aaatctgttt tctattcagt     1980

taaatattag accatctggt aatggagaaa atgtttgaaa atccacctag ttaacctaaa     2040

agtttgcatt tcctgccttt ggggctttga atttttaagt tacatgtctt cgtagatggt     2100

gatcaggata aaactaatat ctctcttaga tgaatcaaaa ttcaccccct tgggcaaggg     2160

agggacccag cctttcttta aacatgtggt tgcctgagag ttgaacaaaa ctggaatagg     2220

gagagaatgg ctttgccatg ctgatcatgg tattgtggag atttaagaac tagtggccag     2280

gcgaggtggc tcacgcctgt aatcccagca ttgtgagagg ccaaggcagg tggatcactt     2340

gaggccagga tttcgagacc agcccggcca acatgatgac cctgttttta ctaaaaatac     2400

aaaaattagc cgagtgtggt ggtgtgtgcc tgtagtccca actgaggcat gagacttgct     2460

tcaacccagg aggcgggggt tgcagtgagc cgagattgtg ccactgcact ccagcctggg     2520

tgacagagtg agactctgtc tcaaaaaaaa aaaaaaaaaa aactagtcag agctgttgag     2580

gtgttgaggc acctgctact gatacacact ataaacgtgg aagatgattt tcatttttgt     2640

agtcatgagc aggatactgt ataatgtata attgttggac attaaagaaa acaaactcct     2700

tcttgtctcc ttag                                                       2714


<210>  25
<211>  518
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  4TH EXON OF ISOFORM 5

<400>  25
gctcagagcc actcagacat tgggaagcaa gtttgtcaag atgacagaga accgaggtaa       60

tggattcgag tgatgaaaca ggaagttcat tcatgagttt ttggccacac ctccaaagtg      120

acgacttagc cagaaatggg ataactgggt ttccctactt ctcttttatc atcctcaatg      180

agagtgacca aatattagag ctagatggaa ccttagtgaa aatctggcta ctcgtcccgt      240

cccaccagcc tgccacccat ttcaagtttg aagagacaaa gacacatgga ccttatgtaa      300

ttactgggga ttaccccagg agtctgtggc aaaagtcagc ttcttccctc cctgcttccc      360

cgccctgtct ctggtacttt ctaccaacac tgggctgttt ctgtgatcac acttaagcgt      420

acctaacctg cgaatgctgt atagaaggtg ctaatgaaca tgatttagct ttaacactca      480

gttttctaaa gggacacgtg ggggcagcaa atgtttag                              518


<210>  26
<211>  248
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST EXON OF ISOFORM 6

<400>  26
cagtgcctag gttttatgta gtgaatttgg ctaaaatggt agagctccct gattctaacc       60

tccctgcagg ttttccacca catccactca cctctacatg gcgaaaacca agggttcact      120

ctctgtcttc agggagctcc acccagcagc agcgtttgac agagctgttc acttcctctt      180

cctggagctg tggcttccag agcccatgct cagcagttcc cctccttctt cgactgctcc      240

tctcttag                                                               248


<210>  27
<211>  3934
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  1ST INTRON OF ISOFORM 6

<400>  27
gtgagttttg ttggtgtcct tcatttccct gactctaaac attggagacc tccacgtcca       60

gtcttgggcc tcttccctgt tcatccacaa gcactcccta ggtgacctca gccgtgctta      120

tggttgttgg ccacagcgtc caaattgact ttgctgcctc cacacttgtc cccctgccct      180

gaccgagcag ccaaggtgac tctgttaaga tacgaagcag atcacgccat tgcttgactc      240

aagcccctcc aaagtttctg ctctcagagg aaaagctaag gtcttttttt tttttgagat      300

ggagtttcac tcttgttgcc cagactgcag tgcagtggtg tgatcttggc tcactgcaac      360

ctccacttcc cgggttcaag cgattctctt gcctcagcct cccaagtagc tgggattaca      420

ggtgcacgcc accacgcccg gctaattttt gtatttttag tagagatggg gtttccccat      480

gttggccagg ctggtctcga actcttgacc tcaggtgatc cacctgcctc ggcttcccaa      540

tgtgctggga ttacaggcat gagccacagt gcccagccaa gctaaggtct ttataatgtc      600

tcccttcggt accaacagct ccatccccca actcccttca attctcaatt tctctttggc      660

gtcctctgta gctcctctgt ccttagctca ctcatgccta ccacacaagc cagccatgct      720

tctgcctcag ggcctttgca ctcactggtt tctctgcctg gaatgtttct ctggtaatgc      780

agatgccacc atatccttgg agacatcctt atctcaactg caaaccaccc tccctctcag      840

cactacctaa cgtctttgtt tatgtttttc cttcagccca taccattcat tatctaccat      900

actatatatt ttacttacct tgtttatttt ctctcctctg gaatacaaag tccacaaggg      960

cagagatttt tgtcttttgt tttcatggtt ctaggctcaa aacctgtaac aatgcatggc     1020

acacggaaga tgtgagaatt tgctgaataa ctgaatggca ccatgttgcc tcacctaagg     1080

ataatgacta agaataggaa aaatttactg tgcaaagatc agttcttaat agctgtctac     1140

atctcagaac aaaaaaaatt agatgtaaac cattgcacaa aggattagat gaaatttttt     1200

tgaaaaatca gacattggag gtaagtattg ccataagcca tataagcaaa acaatcaaat     1260

ctctggagac actggaaaat aagattgatt gtaaatttgc tgctgacgtt taccattgct     1320

ctgcataaat gcaaaaggaa gcgctggcca acttctcatg ggtttccaag tccaggtgtc     1380

taaaatttgg cagagctggg aggactgctt gaggccagtg gtgcaaaata agcctgggca     1440

acatagtgag attctgcctc taaaacaaaa caaaataaaa gacaaaacaa ctaattctgt     1500

tttttaaaaa aaaaaaacac acaacagcaa acttgactat aaagattatt gctgggcacg     1560

gtggctcagg cctgtaatcc cagcactttg ggaggctgag gcgggtggat cacctgaggt     1620

caggagctca agaccagcct ggccaacatg gtgaaaccct gtctgtacta ataatacaaa     1680

aaattagccg ggcatggtgg tgcatgcctg caatcccagc tactcgggag gatgaggcag     1740

gagaatcact tgaacctggg aggtagaggt tgcagtgagc cgagactgcg ccactgcact     1800

ccagcctggg caacaagagc aaaactccgt gtccaaaaaa aaaaaaaaaa aaaaagatta     1860

ttatatataa tcattcaagg cctgtatgac tcagttccct tagaaaaatg tcataatttt     1920

tatattactg aatattattg gcgttatttg tgtagcccac ttaagtgaag tcaataacat     1980

gattaagtgg catattatct tcatgtcagt caaacgttat ttggatttta taagttaggg     2040

tgagatacaa ataagtgaaa atactttttc taatgaataa tgatgaatct aaaataggat     2100

tgacttggct gggcatagtg gctcgtgctt gtaaccccaa cactttggga ggctgaggca     2160

gtaggattac ttgaaaccag gagtttgaga ccagcctcgg caacaaaggg agaactcttc     2220

tctaataaaa ataagaataa aaaattagcc aggtgtggca atgttcacct gtggtcccag     2280

ctacttggga agctgaggca ggaggatcgt tggagcacag gagttcaaga ctgcagttag     2340

cggtgactgc actccagcct gggcaataga gcaagaccct gtctctaaaa aaaaaataat     2400

aataaatagg actggctcgc atatgtatgc aactattttg ttaccagtga cagaatacat     2460

gtgatgatgt tttctagtct tgtgactggt ttcttagttg tatgttttat ttttagaatt     2520

gttgtttcca ggctgtgttg tttggaaact cagctgacag atgtatgaat ctgattccag     2580

agtctctgag agctggaaag ggcctcagag atggttggga ctgatactct tgcattacag     2640

gtcaggaaat acaacccaga gacaagatga aacttgccca aggacataac agccagcctg     2700

tggctaggct gataccagat tcctgttctt cccattccag tcgcatgcta ctcaggaaac     2760

tcatcagcat tcccgaatat tgagtgtttc ctacctgtta cattagcagt ttttgagaag     2820

ggtatatatt gtagttaaat taatcagctt tgggaaaata tgggtgcagc atgggaatag     2880

agactgtcat ttgagaatca ttgcagaaat gacaaaaccc tgagaatgaa gaatgggcct     2940

gcaatagtcc tggcactttg ctcttccacc aaactgaact gtagctcaaa ggacaatgac     3000

ttcacgtctg tcactctaaa gcctgttcta agatcacatc ccctctggct ctccctagat     3060

acttctgatt atagttggta atcatgccca ttaaatgtct ttggtttctt ggtacacaga     3120

gagaaggtaa ataatgggtt catgatttag gtaagaatac acaaatattt ttcacactat     3180

aaatctgttt tctattcagt taaatattag accatctggt aatggagaaa atgtttgaaa     3240

atccacctag ttaacctaaa agtttgcatt tcctgccttt ggggctttga atttttaagt     3300

tacatgtctt cgtagatggt gatcaggata aaactaatat ctctcttaga tgaatcaaaa     3360

ttcaccccct tgggcaaggg agggacccag cctttcttta aacatgtggt tgcctgagag     3420

ttgaacaaaa ctggaatagg gagagaatgg ctttgccatg ctgatcatgg tattgtggag     3480

atttaagaac tagtggccag gcgaggtggc tcacgcctgt aatcccagca ttgtgagagg     3540

ccaaggcagg tggatcactt gaggccagga tttcgagacc agcccggcca acatgatgac     3600

cctgttttta ctaaaaatac aaaaattagc cgagtgtggt ggtgtgtgcc tgtagtccca     3660

actgaggcat gagacttgct tcaacccagg aggcgggggt tgcagtgagc cgagattgtg     3720

ccactgcact ccagcctggg tgacagagtg agactctgtc tcaaaaaaaa aaaaaaaaaa     3780

aactagtcag agctgttgag gtgttgaggc acctgctact gatacacact ataaacgtgg     3840

aagatgattt tcatttttgt agtcatgagc aggatactgt ataatgtata attgttggac     3900

attaaagaaa acaaactcct tcttgtctcc ttag                                 3934


<210>  28
<211>  605
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  2ND EXON OF ISOFORM 6

<400>  28
gctcagagcc actcagacat tgggaagcaa gtttgtcaag atgacagaga accgaggtaa       60

tggattcgag tgatgaaaca ggaagttcat tcatgagttt ttggccacac ctccaaagtg      120

acgacttagc cagaaatggg ataactgggt ttccctactt ctcttttatc atcctcaatg      180

agagtgacca aatattagag ctagatggaa ccttagtgaa aatctggcta ctcgtcccgt      240

cccaccagcc tgccacccat ttcaagtttg aagagacaaa gacacatgga ccttatgtaa      300

ttactgggga ttaccccagg agtctgtggc aaaagtcagc ttcttccctc cctgcttccc      360

cgccctgtct ctggtacttt ctaccaacac tgggctgttt ctgtgatcac acttaagcgt      420

acctaacctg cgaatgctgt atagaaggtg ctaatgaaca tgatttagct ttaacactca      480

gttttctaaa gggacacgtg ggggcagcaa atgtttaggc aaaaacaatt ccagttctag      540

cctctactgt ctacatatgt gtatacattt gggaaacgtt tgggaaaggg atatttgaga      600

gcttc                                                                  605


<210>  29
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  GAPMER 1

<400>  29
ccgacctgaa ttgcaa                                                       16


<210>  30
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  GAPMER 2

<400>  30
gtagaggcta gaactg                                                       16


