                         SEQUENCE LISTING

<110>  Aelian Biotechnology GmbH
 
<120>  SAFE HARBOR LOCI

<130>  AE002P

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  1
aagtgctgcc cggcgctccg gaagcgattc atcgggccgc gagcgccctc cc               52


<210>  2
<211>  119
<212>  DNA
<213>  Homo sapiens

<400>  2
cagcctctcg gccccgcctc gatttttagc tttataggaa tgctgttgct ttaaatccga       60

aatcccgtgc cggtatcaac tctcgcgatc tccgaggccg catacatatt acccacaat       119


<210>  3
<211>  125
<212>  DNA
<213>  Homo sapiens

<400>  3
tggcgcgctg cgatgacgtc ggcggcacgc ctgcgactcg ggctccgcgc aaaagatggg       60

gttggggtac ggcgcgtaga gatgacgtcg ggttctacgc gcagtggtga cgtcacggga      120

gcgcc                                                                  125


<210>  4
<211>  141
<212>  DNA
<213>  Homo sapiens

<400>  4
cttgccagcc ccggacttct gcgcgcgctg catgcccatt ggatgtgctc attcccaccc       60

cagccaatcc cgaaactcgc tcggacgctg acagaagact gcgccgctgc tttgggattg      120

gtagctgagt tttgtgtcgc g                                                141


<210>  5
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  5
agaaggtgga aggagaaaag aaaacttcgc gccaatcggc gtggccccgc ccccagaccg       60

tcccttcgtt gcgacaccaa ctagctcgcc ccgcccactc cgtacaccta agaggggcgc      120

atgacgtaca tccgctaaca tgcagccgcc atcattgatt cgataggcga cgcggggagc      180

ggaagccctt tacac                                                       195


<210>  6
<211>  239
<212>  DNA
<213>  Homo sapiens

<400>  6
agctcccact gccgctcagc gccgatgcgc cgcccgcctc gagctcacat tggtcctggc       60

agccttcccg ccacaccaac caaccaatag acagggcgat tctgcgctcc cggccctgct      120

gcaggctgtc tcgcacttgt cattggtcac tgcagccgcc ccaccccccc cggcgcgcca      180

gtggctgggc ggcctcgctg gggcgggccg cagttcctgc gcgtgcgcgc ttggcctcc       239


<210>  7
<211>  341
<212>  DNA
<213>  Homo sapiens

<400>  7
tcctgaaaga cacgtcagcc ggaagcaaga cacgggcacg ctaggaaatg tagtttactt       60

tttccgagcg gcggcgaagt aagccaatgg gaagctccac aataatatgc aagggggcgg      120

aaggcgtaag tgcgtcacgg agagcatctc gggaattgta gtgtgtttct gcaagccaat      180

gggatccggg gaaacatgat aaggatgcgg tcgaggctgg gaataggctg agggagctgg      240

agagggtggg accacgcagg aggcagatcc aataaacagg aagatttttc tcgtgacgtc      300

gtcggcgcgc gccggaagcg cggatcacac gggcccctac a                          341


<210>  8
<211>  343
<212>  DNA
<213>  Homo sapiens

<400>  8
gtatgcagct aactacttcc gcttccgctt gcgtcccctg cgtccctggc tcgaggtttt       60

ccgccatttt gagtgtggcc ctagattgtt ctcaatactc tgtccttggg ttttgtaagt      120

tgaaagttga gactaggaag gcatatcaca agaactataa acagagtttc aatgaggcaa      180

cactgaggag gagttctact ccttcctcat ccccttccaa agcccctgaa ctcgagtagc      240

cgcccctccc atcatggttc ccttagtgtg gtctcgccgc acaccccgcc cattgacccg      300

gaattcttct ctgcctggtc ttcaggtccc aatcctccgc ttc                        343


<210>  9
<211>  371
<212>  DNA
<213>  Homo sapiens

<400>  9
tccggaaata cgtaaaaaca gagcgccggg tccacgcctt ccccaaggaa tggggcgtgt       60

ctcggcaccc ctcggtgacg cctccactga catcatctgc ggattcccgc cccgaggttt      120

ctaaatccag acattcccgt ttggctgagc actctaggcc tacatccatg aagctaggag      180

agcgacactc aaagactgca ctattgagag aagctaacgt taaaggcagt gaatatattc      240

gggagtccag ctccggaacc cgggagctct tttagtggga ggggcggcgc tgatggcgct      300

tctggcctcc gaatgctagg gggcgctgtg atcgccgggc ggcctcttgg gcgctgggag      360

tccaccgcgc a                                                           371


<210>  10
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  10
cgttagaatt caaaggttct tctttttaaa taggagttaa accctctagc tagaaagccg       60

attggcctgc gctcgagcga ggctgccttg tgattggttg acaacaaacc cgacgccttg      120

agtcgcgttt aagggcgcac accgcgcgca ggcgcacttg ctccctaaga acccggaagt      180

ggtggagcca acggccagcc agacctgtgg cagtcccagc cccagggtgc tctccgcggt      240

cggccattta tcggtgaagc aacagcccct tgacgtcaag cttgacgcat tggagataaa      300

gtccaaggag gtgaactaac ctttgaacgt gccagtaagt aagatggcga gaaaagcaag      360

agagagtggg accgatcgat agcgcagcgg tcggcttggc gccctttcag cgtgcgcagt      420

gaacgtgcgc tcggagcggt a                                                441


<210>  11
<211>  527
<212>  DNA
<213>  Homo sapiens

<400>  11
gctcccctca ctccagttgc tcagcccgcc gctgagcaca gccaatccgc ggccgtccac       60

tcactgtttc ggccaatcac cgagcagacg gcccggaagc tcgagaggct cgtgccaggt      120

cggggggcga aggcgaggcc agcccaccaa gcaggggcgt caccaaggga aagccaatca      180

ccattatttc tgaagcccaa gggggcggga cgagaagtca acataatggt ggtgctgctg      240

gaaatctagc acctggggag agcctgagac ttgtgtatct aattgcctat tggacacctc      300

catctgggta aacccaggca tccagaactt tccctcaaga cttacctccc tcagtgcagg      360

tcgggctggc ctcacgcatt tcgcttggat gcctaaatct gtctccacgt ggggccggtc      420

gataaaacaa cacttcccag aatacgctgc gatccattcg cggtctgcac ccggaaagta      480

cacctcccag gggtctgtgc gcgcctccag ggaacgggtc ttgtggc                    527


<210>  12
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  12
gtcagctggt tgtgtcactt gacccctctt gttgctaaga ggcagcaggg acacccattt       60

tcacttccgc ttccggttgt cacaggcgac gaagggggag gacagaacag aggcgttgcc      120

cggatgtcga ggcgcgcgca ccgcggaacc acccctcaat tccggttcgc ctcccaaccc      180

ctccccatcc agcttccctg cggctgcgca atacgcggca cgcgccaggc caaagactag      240

gagcgaagcg tgcacgcctt gtctttctcc acctttcgtc tttggtcaca gcgccatctc      300

atggttagct gaaactttga aagaggattc attcttcaga ggcaaggaat cggagtccta      360

tgtctttctc gcgccttgaa ggttacttag ctaaagctaa gatagcgaga aacagtactt      420

ttcaggtcct tccatgatct acattcgtcc ttgttctcgg aggacccaga ctctatggtt      480

aatgatgaag aggggcctct attcgttcag cgcttgcgca tgcgaggagg ttccgcatgc      540

gcggtg                                                                 546


<210>  13
<211>  611
<212>  DNA
<213>  Homo sapiens

<400>  13
ccgcgcttgc tccgccgcgc tacaggtcgc gggaggggcc aggcctaggt gcttcgccaa       60

aagagggcgg agctgcgcac acgtgctggc tccccgccgc ctcgggctcg gctctctccg      120

cgcagaggtt tcatggcttg cttcaatctt ttgatatctt agagtaattg cttccaattt      180

ttgggcatcg ccgcctcagt ttacagaata gtatggatct ggtgccagag ccgggaaaac      240

gatgcgcatc gtaaaccgca aaacactgag catccaggac agaagccaag gcgcttggct      300

tggttgaagg ccagtgcgca tgcgcgagtt tacccttcgc ggactgggcg agctcttgcc      360

actcctacct ccgggcttca gtcttcgccg cctgttctgg tcctttcccg ggccgctatt      420

ggaagaaccg tgaactatgg aaggcccctc tggattggct gggctggccc aagagtaagg      480

agagccctct tcctggcggt ggggaaggga cggcggcgat tggcggacgc tcctggcagg      540

agagcgcgga ttggtcaggc acggagcagg aggcggggct gatagcccag cagcagcagc      600

ggcggcggcg g                                                           611


<210>  14
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  14
agccggtacg ccccagaggc tcaccggaag tgccggaccc gagacccgga gggggggtgc       60

ccgggacaaa gcgtcggctg caaaagagaa aaggccaggc gaagacgcta ggctctaaaa      120

caccctcagt agaagcatta aaatgccctt tcgtgattta tttccccttt tataggtatt      180

tttaaacgtt attttaaatt acgtgttgac agtattcccc tccagacgaa tttagtaggg      240

cccattgtcc ttacgactac actacccaca atgcactacc cagactgcct ctgcttcagc      300

catcgaggac tcgggcggaa ctaagctaca aatccttctt caaaccacac caaaaaccta      360

ttgcaaacgt aaatgctgcc ccattgggta tgtgactgag tttaatgtat ggttagaagt      420

atactttccc tgagggttcc cagtgggagg cagtaggctt ctcttcccaa agtaaagatg      480

tccgcccagc gtcgcttttc tgggtaaaag cgagtcagag ttgaaggggg caacagtgtt      540

tgcgttcggc ctcagaggtg acgcttcttt gggggcgggc tggagttttc tggccgtgaa      600

tggcagagcg ctaatggccg cctccaatgt ggcccaatca gaaagaaagg aaggctggga      660

actaagaagc tattggttgg tgatccctgg accaatcgga ggagccgtga tttggcggga      720

gtcttgaccg ccgccg                                                      736


<210>  15
<211>  737
<212>  DNA
<213>  Homo sapiens

<400>  15
ttcttccttg tcaccctccg cagtttggca ggacagccaa taggcacacg agatcctcca       60

tcaaggggcg ttcccatctg gggatcccca cgccggcagc accaaggcct ctgggtcagc      120

ttctttaagg gcaagcgccc ttagagaagc agcacggaag caaccaatca actggtttct      180

ccaattagcc cccaagtgga tcagcctgct gaactgtcgg ctagggttat aggtggttct      240

gagtccttcc ggaagctgcc gaatcttaga agtcgcgcca ctgttgtggc gatggaagaa      300

ggcgaagctc tacagaaacc attttggttg agggaagagt ggttttaaag ttaatttgga      360

aaggagccgg caagcaacct tcagtcggtg tgcggttttt acagttgaac tgtttccagc      420

cgctaattat gattgtttta gcggttcgtc atctgaaaac tgcattctgc acggcggtgg      480

tggggggagg acgaggatgg agaagcctgg gcggacatat ttattagctg cggtcctaag      540

tcacgtgtga cattctgtat ccagtctatc ggttatccca aggagaacgc cctgccggaa      600

tggccaatcg ccttgagatg tccccgccct attcgccatc ttaacatagg gcattcccca      660

cagctgcagg caccagtgaa gcgtctaagg gaccatcttg gttgagggcg gaagtgagga      720

ctgtgtcgcg ctggagg                                                     737


<210>  16
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  16
gctgtgacct ttcaccccgc ccctcgcgcg ccggcgcgcc gccgcctcac gcgcagccgc       60

actgctcgcc tccgcgcacc ctgccccctc cactccggaa cctccatctt tctcctggac      120

tgggccttct ggggtcatgc tcctccctcc cacccgctta cgacactgct tgtggggctg      180

gctcggtagg ccctggcggt aaaatccaga tttttccacc cctccctctc ttgtcccata      240

tccgcaagat agtttttctc agccccgttc ttcccagttt gtggtctcca gagtgacctt      300

caaacgctgt tgcctcctag tagggtttta taaagttagt tcttctaaat gtaaagaaat      360

ctgtggaaag ctcaagttta agttaggtgt tttaaaacaa acgtagttaa caatcggcca      420

gatagattgg ctaccctcca gcacgcctca agttttaaga tcacgtgatt ggcccaaacc      480

tcagagcctg gaattttacc ggcggactcc agagggacgg aacgccaccg ccatttcctg      540

tccctcgatt gtggcgtgaa cgtcacttcc ttagcaatgc gctttaactc ttgctgtcca      600

cattttccac attgtacttt ataacatact ctttgtgaaa atttatcttt tatttcttta      660

atccaagaaa attaatattc aagggatccg taaaaattca ggccccccga gatgtagagc      720

gctgggatgg aggaggcagg gcggagctcg acgtcatgtg actggttggg cccgcccccc      780

cccccccccc caacctgtgc agctgaggac ttc                                   813


<210>  17
<211>  1433
<212>  DNA
<213>  Homo sapiens

<400>  17
actctcgggt cttcccgcgg ccgccgaaga cccgctgagg cagaagctgc ccgcggcgcg       60

cgccttatca aaaacccgtt ttcttgccat tgaaagagaa actgggaact tagataacag      120

gaaaatctcc acatacacta aattcacatt attttatacc ctgtaaaagc tcccaccaga      180

tataaaaact cattataatg gcatgcgttc cgtcacaact tcggacagaa gttgggtctt      240

tgggcaggaa gtggaagcca tagaggaagt catggagcga gagtgatgtc tgtagtgaag      300

aatttggcgc catcttgaga aggtcaaagt gattcttcga ttaaatgcct tacttatcgc      360

ctagtgtgac ctggcgcttg ggtttactct ccccagcaac tgcgcctcaa acgcaaagaa      420

aactgcaggt cctcggggaa ggatcgattt caccattcaa gagaaaaatc catttcccag      480

attcctcccc tttatgtaaa cgtctggtac ctagtagacg ttaaatacac gtgagttttc      540

cggttttata agatcacata ctgcaaacca acagtaaatt acattaatac gcatttcttt      600

agaaattctt aattgctagg cactgacata taaattgagt ttgctgttgt tttagagaga      660

aaaatagaca tattcatttt ttttcaatca ggacatggta ttcgtttcct tcttaagctt      720

cccatttttg aggtaggaaa gtattggtgt gtgtctctat ctctaccttg ctccctcatt      780

agcaggctta atgggcagga attatgtctg ttttgctttc cgttggatcc ccgggtctag      840

tagagcgcct tgacacatag taggtactcg acacagatgc tggcttcatg atgaagcaat      900

tgtcctcgaa ttaatacaaa agggaagatt cagactcagc gagccggtac cattcgtcta      960

gggacacaca gccaggaagg aaccgaacca ggattctaac ccaggattac ccaagttcga     1020

attctaattg aacataagtc cttagcgacc ttggacggac ttactaaact gccctgaatc     1080

tcggcttcct tagctgcaaa atagggttag gaaaagtgga ctcggtgctc ctctgcgccg     1140

cattcccgca gcgggatttg tgaaagcgaa cttgagcccc acactgcaga agccctgagg     1200

tcctgtctca accagaatcc agcacccagg acaagccctc cagcgacttc agaccttccc     1260

gctcccgacc ccgcccgccc ccgagaggcg tggtcaaggc ggggccagaa ggcggacgcg     1320

tgcacggagc ggtaaagcgc aggcgcaaag cttcggtgac gtcagagagg cgcgctccca     1380

gctcggagcc gactcgcaga cgcgccccgc ccctcggcgt cgctctggac tgg            1433


<210>  18
<211>  2020
<212>  DNA
<213>  Homo sapiens

<400>  18
gtctctctgc gcatgctcac acgcgacctc cccacaaagc tactccgcgg gcctgcctgg       60

ctactgagtc gcgaaaatat atcgtagtgc cgcaatgact tctgggtact gtagtccaac      120

atgtggactg gccactcggc ttgaagcttc cttgggattg gatgttggga ccgtccaaac      180

acggcgactt ctcatttgtc agcctgcggc agtttaaatt gggtggcggt ggtggcatgt      240

cctgttagct gtggagtctt ttcctcttat cttgcgcctc cggttgtgcc ttaatgacac      300

ttttgacatt gtgtatcaca accaactggc aaaaactagt aaatcacggg ctcctgacgt      360

ggcagctctg gctaaaatgc aggtggacgt cctaggtgcc cagggagttc gggctcactg      420

gggagtaggg tgaaggaaac cctgaaaccg agaggctgga agcccgactt gcgcagcata      480

aaaacacctg cagggggaaa gcctacatga ggtacgggtt gtcatcccgt ctcatcttgg      540

ccatctgact gatggagatc ctcaggcacc cagcagactg gggtgtcacc cccactaccc      600

actgcccagg gctgacctcg ggcggaagag cgacattcaa atatttgttg catatggagc      660

aacagaccag ggtggaagag agagaaagga ctttccagga aggtccaggc ttgccaggac      720

ttctatgctt ggactgctct gtccccaagc tcgctggtgc ccatcaggag cctgcttggc      780

acctttgctt atttcttcga ttgttcctca actcagaggg ggagaggcaa gattatcact      840

cccatagcct ataacatgca cgcttaaaca caacccctct gacatggctt cagaccgcat      900

ccacaggtga aaagcaccaa atccaaacaa tcaggccaca aacccgtcaa gagctcgccg      960

gtctggccgt ccagtcgccg cccgccttga gactcagcct gagctacagc ttcgaaacta     1020

gcctctagcc ttctgggtct cagcacaact cttgagcaat ccaaccctgt ggccgtgggc     1080

agataccaag atgcacagtt agcacctccg acaggaccgc ggctcggcgg ggctcgccgt     1140

ctacacgccc attcccaggc ccacggccac gacacccaga gctgcctcct gccctgggct     1200

ccctggagcc tggtggccgc ggctcatgct gcagtcaccg tgtggccagc tgccaagcgc     1260

cactacttgc acctgaagtc gcagccccgc gctgcgcacc cagtcgaggc gccaacacgc     1320

gaactgggcg ggagtggccg gcccgcgggg gagcgaggaa cgacagggtt ccccccactc     1380

gctgcccaga ctggccgcgg gatagcgcgc cccccccaaa gcctgcaccc ctgccctgct     1440

cctctatcat tccgtccccc ttgctctgtc aaaccctgcc ggggctgctc tgtctctgcc     1500

gacccgccac ttgcccgaag ttcggcctga ggagcttggg gccctgagga gcgccgacgt     1560

aggcagccag ccagtcaatc agtcagaggg tcacggcggc ccctcggcta ctcagtggca     1620

gccaggccag aaagaagcag ccgccaaccc tggagcagaa tcctacagcc gacctgacct     1680

agtaggcccc cagccctcca gagcttgggg tattgcagag ccgccacaag gcctgccggg     1740

agtagtagtt tgtatagttc gcagccggcc agggcggagc cgggtgggtt ggtggggagg     1800

gcggggaaac aagcctggac cacaactccc aggagtaccc gcgacggcgg cggcctcgct     1860

gtcgcactca ggctataggg ggcgcattgg gcggaagacc ctgggccggc aggaacttgc     1920

ttgtgattgg atgttgtggg acggcggctt ctcattcgtc agcctgtgac tgtggagttt     1980

gaattgggtg gcggttgact gtagagccgc tctctctcac                           2020


<210>  19
<211>  4357
<212>  DNA
<213>  Homo sapiens

<400>  19
cacatctgcg gcatcctctc ggccaccgta gagtgtccca cgtgtccgct tcctcttccg       60

ctactcgccc gcgcgtctgt ctgtcaagag agacttccgg catgcctttt tttttttttt      120

ttttcccttt ccccgcaccg tcacctggtg gcgcttactg gaagccgcac cgaggcgtgt      180

gctgtatttt aaaaatccca tttctggtca atttctccac gtaatcagac acccgcagag      240

aaactgcata taactctttg cctcaaggct tttagacaag cagagggcca aaacttgcat      300

aaaatggaaa atcatcatca ttaacatcag taccatctaa attaagagct tctaattgtt      360

ttaagggaag gtggaagcta aaatgaaccg gcccatccaa cagagggcac tatctgtgga      420

ggaccaacaa aggaaaacag agcggaaaat atgggcgcac atgtgcctcc agttcatgaa      480

gttatttgga gggagggggg aagaattaaa cttacattat tgattacaaa aacagttgaa      540

aatctgttag agtgaaaaca gccatggtaa tctacagaag aaaagggaga atggaaagta      600

aagatcattc atgtcttgaa ataagttgtc tacagtctgt gagaacttgt gggaggtgat      660

cctagtgtga tatattagtg catgagccta gcaaggaaat cacatcacca cagggcttag      720

cgcttagaat tagaactaag tcctcattat ttgtgagaaa ctcaaaacag aacttaacaa      780

aagtgtttaa caactttcaa tttttaagaa gggacgctat ctcattttca gacgccatgg      840

atcctcacta gcaaaacaca atgtcacaga caaacgaggc atatcaggtt tttctaactc      900

atttcggtac tccatcactt aatcatgaaa taatgttgac tatatatata tatatatata      960

tatatatata gtcaacatta tgggtttttt ttgttttttt tttttttttt tttttgagac     1020

ggagtctcgc tctgtcgcct agactggagt gcagtggcga aatctcggct caccgcaacc     1080

tccgcctccc gggttcaagc gattctcctg gctcagcctc ccgagtagct gggactacaa     1140

gcgcccgcca ccacgcccag ctaatttttg tatttttagt agagacgggg ttttactatg     1200

ttggccaggc tggtctcgaa tccctgacct cgtgatccgc ccgcctcagt ctcccaaagt     1260

gataggatta caggtgtgag ccaccacacc cggctctgat gtttacaata ttataccaac     1320

aagggttgga tcgtgtgtga cttatctaga ggttaagagc aaaagttatg aaatcacagt     1380

gccatcatgg gagtctagct ttcaccattt aaagttgtgt aggcagccag gcgtggtggc     1440

tcacgcctgt aatcctagca ctttgggagg ccaaggtggg cggatcacct gaggtcagga     1500

gttcgggacc agcctggtca acatggtgaa accccatctc tactaaaaat acaaaaatta     1560

gctggggttg gtggtgtgcg cctgtaatcc caggtactcg ggaggctgag gcaggagaat     1620

cgcttgaagc tgggaggtgg aggttgcagt gagccgagac catgccattg cactgcagcc     1680

tgggcgacaa gagtgaaact ccatctcaaa aataaaaaaa aataaaaaat aaagttgtgc     1740

aggccgggcg cggtggctca cgcctgtaat ctcagcactt tgggaggccg aggtgggcag     1800

atcatgaggt caggaatttg agaccagcct gaccaatatg gtgaaactcc gtctctacta     1860

aaaaatacaa aaattagcct ggtgtggtgg cgcattcctg taattccagc aactcaggag     1920

gctaaggcag gagaatcgct taaatccggg aggcggaggt tgcagtgagc caagattgtg     1980

ccactgcact ccagcctggg caacagagca agactctgcc tcaaaaaaaa aaaaaaaaaa     2040

aatatatata tatatatata tagatataga tatagatata tgtgtatata tacacatacg     2100

tgtatatata cacgtatata aagtgtgaac ttgggaaagt tatttaatct tattgtgtgt     2160

tagtttcccc atttataaca tgggtgagta atatgtatcc tatttcttag agtcaatggg     2220

aaggttaaat agcaaaatga aggtaaaagt aattagaatg taacaggcac attacaatca     2280

ctcaataaat attcttctgc ctcagcctcc cgagtagctg ggactacagg tgcgcaccac     2340

catgcctggc taatttttgt atttttagta gagacggggt ttcaccatat tggctaggct     2400

ggtcttgaac tcctgacctc gtgatctgcc tgcctcggcc ttccagagtg ctgggattac     2460

aggcatgagc caccgtgccc agccggctga ctattttctt aagaataagg atagttggtc     2520

acctcgggag gctgaggcag aagaatcgct tgaacttggg aggcggatgt tgcagtgacc     2580

cgagatcccg ccactgcact ccagcctggg tgacagagcg agatgcggtc tcaaaaaaaa     2640

aaaaaaaaac aaaaaacgaa aaaaaagaaa aatagtcggc cggggacggt ggctcacgcc     2700

tataatccca gcactttgag aggccgaggc gggggcggat cacttgcggt caggagttgg     2760

agaccagcct ggccaacatg gtgaaacccc gtctctccta aaaatacaaa aattagctgg     2820

gcattgtggc gcaggcctgt aattttagtt actctggaag ctgagccagg agaatcgctt     2880

gaatccggga ggtcgaggtt gcagtgagcc gcgatgaagc cattgctctc caacctgggt     2940

gacaagagct agactctgtc tcaggaaaaa aaaaaaaaga aaataggaaa gctgcccgca     3000

aagcctgcac cttggacacc tcgtctgcac taacatttgg gaaattcttc ttattatttc     3060

tccggaacat atatatttac attctttaca tgtctgtttc acgttaaaga aaatatttct     3120

ggagcaatca attttttttt cctttttttt tttttttttc tgagacggag tttcgctctt     3180

attgcccagg cggagtgcaa tggtgcgatc tcggcccact gcaacctccg cctcccgggt     3240

tcaagcgatt ctcctgtctc agcctcccag atagctggga ttagaggcat gcaccaccac     3300

gcccggccaa tttttttttt tttgtagtag agacggggtt tcgccatttt gcccaggctg     3360

gtatcgaact tctgacctca ggtcatctac ctgcttcggc ctcccaaagt gttgggatta     3420

taggcgtgag ccactgcccc tggcttccaa tttttttttc cttttttttc ttttcttttt     3480

tttttttttc tgagacggat tttcgctcct gttgcccagg ctggagtgca atggtgtgat     3540

ctcggcccac tgcaaccttt gcttcccggg ttctggcgat tctcctgcct cagcctcccg     3600

agtagctggg attacaggca tgagccacca cgccccgcta attttgtatt ttgtatttat     3660

ttatttattt attttcgtag atacgtggtt tcgccatgtt ggccaggctg gtatcgaact     3720

cctgacctca ggtgatccgc ccgccttgcc ctcccaaagt gctgggatta caggcgtggc     3780

catcgcgccc ggccaaatat ttttcaaaat ctaattttgc ataatgacca agatttgcag     3840

aaaaatacaa attaaagaga tcttttaaag taaagattcg tcataaaagt cacagaaata     3900

atactcatga ataataaatt agaatgggca atgttaagta cttgaaataa caaaggtttt     3960

agagtcaggg tttctgcagt ttccctagcc atataacgag gagactgtta gagaggatat     4020

cctaaaatgc tttccaagtt tacccacctc taactcggaa gaaggcaatt taaactaatt     4080

tggtttaccg gaattcaaat acgtacaatt caacataatg aattgaactg aaattgaaca     4140

cctgcttgcg taaacctagt cggctcgagt tgttctggtt ctggattggt cagtctagag     4200

ttccaggggt gtggccaaaa gtctgtgagg cggggccgta ggcagcctaa atcaggcatc     4260

ggcgcggtca gcctcgtggc gcgcccacgc ccccacgccg gctcttcccg gggtccttcc     4320

gtgcgcgttg atatgattgg ccggcgaatc gtggttc                              4357


<210>  20
<211>  9648
<212>  DNA
<213>  Homo sapiens

<400>  20
aaaggaaagc taggggccac cctggccgct tttcagggtc tgcgcaggcg ccttgagcac       60

tgcgtcgcga cgggagagag ctttacggct tctgttgcgg ctaacgggcg gggcgtctgg      120

tcagcggcgg gaaggccctt aggcgctcag agcgggcggg ccctgtgagg cggaagtggc      180

gggctctgtg ggcggaaggg gcggggcctg ggagtgtcgt gtgcggactg aagggaaggc      240

tgcgggagtg tgcttcgcgt cctctgtagt cgactaccgc agctcttctt tgcattctgg      300

ctctttaata atctcccttc gccctttctt taaatcagtt cccaccctcc caacacctgt      360

aatctttctc ccctctggac tccctcctcc ccgaatcccc cgcatcagaa tcttcctttg      420

gaatctactg caagaaatct ggctggattc tcagattaag gacttccaga atcctatcct      480

ccctagaatc cccctccttg gggatcctct cccagaatcc ttttcccctc agagcccctt      540

cccctcagaa tctccctttc accagaatgt ccttcctttc agtttcctct tcccagaatg      600

tttcccatcc ttctctcaga tggccaaccc caaatgtccc tcttaagagt gctcaactta      660

gacccccctt ttccctgaat ctccctccat tcggtcctcg tcccctcagt cacccttccc      720

agaatctttc tcttgtcagg acccagtacc cctggaatct ccctcctcca gaatctccct      780

ttcccggcaa atcccccttt cccggcaaat ccccctttcc cagaacaccc cgccccgcaa      840

atccacaaaa acttttctct cagagacccg tccctcaaaa tctacctttc tcctgagttt      900

atttcccttc cgagactcct cttcccagca actgccttcc ctggagtttt ccctccgtta      960

gaatccccct ctcctaagag accctccccc aagaattaac ctcttccccg tccccaccct     1020

agaatctctc tctttttttt gagacggagt ttcgctcgtt gccctggcta gagtgcagtg     1080

gtgcgatctc gtctcactgc aacctccgcc tcccgggttc aagagattct cctgccttag     1140

gctcccgagt agctggaatt acaggcgtct accaccacgc cctggtcgtt ttttgtattt     1200

ttagtagaaa tggggtttca ccacgttggc caggctggtc tcgaactcct gacctcaggt     1260

gatgtgatcc gcctcagcct cccagagtcc tgggattaca ggcgtgagcc accacgcccg     1320

gccgaatctc tctgtttttt gttttttttt tttctttttt ttgagacaga gtcctgctct     1380

gtcgcccagg ctggagtgca gtggcatgat ctctgctcac tgcaacctct gcctccccgg     1440

ttaaagcgat tctcctgcct cagcctcttg agtagctgag attacaggca tgcaccacca     1500

cgcccggcta atttttgtat ttgtagtaga gacggggttt caccatattg gccagactgg     1560

tctcgaactc ctgacatcaa atgatccact catctcagcc tcccaaagtg ctgggattac     1620

aggcgtgagc caccgcgccc agcccctaga atctctttct ccagaatctc ccagtcatct     1680

ttttcctctc ccccaaatca ccctccactt aagcctcctc cccacagaat tctccatccc     1740

cagcccccca accccacctg aggaacccca ggattgggtt gtcctctggt tccccggcag     1800

atgtccctgc gtctcacccc atcaagagtc tccccagcga agaggttcct ctctcagagc     1860

tagagggagc ccacagttgc ctcagtttct ctggcagtac agggtctggg atccagggtt     1920

caaaagggcg tcgtggtgca ccttgccaaa gagggtggag acagggagac actggagggc     1980

aggtctgggg ccagagggaa aagccagccc ggagtccagc tctaaaaggg tgagggggga     2040

gggggctgtt gggagggagg aaggaagtac ccagaggctg accgggaggg acacagacac     2100

agcccaaaga aatgtaggca caagtggaga agaagagaaa gatgaaaggc caagggagaa     2160

gaggaggaga aaagggagag accaggacag tcaagagatg gacccccaaa acaagcccag     2220

tgacagattt agaggcagag aggccaaccc tcagacaaaa aagagataaa ggcaggcatg     2280

atgtttccaa aatacttgag acagaggcca ggtgcagtgg ctcacaccta taatcccagc     2340

actttgggag gccaaggcag caggatcact cgagcccagg gttcaagacc agcctggcca     2400

acatggtgaa accccgcctt tactaaaaat acaaaaatca gctgggcatg gtggcaggtg     2460

cctgtatccc agccacaagg gaggctgagg caggagaacc gcttgaaccc gggaggcgga     2520

ggttgcagtg agctgagatg tcgccactgc accctaggct gggcgccaga gcaagactct     2580

gtctcaaaaa taaataaata aataaactct gtctcaaaaa taaataaata aaataaaata     2640

aatagagcag agacctcaaa tattcacttg cagacacaga taaaggctag cacaggtgtt     2700

ttccaatgaa gacacaggca gatgagagga tgcacacatt ctacctgtac tttttctttt     2760

ttttttttta aattgagata gagtctgtgt cacccaggct ggaatgcagt gatgcaatct     2820

gagctcactg caacctccac ctccccggtt caagtgattg tcctgcttca gactctggag     2880

tagctgagat tacagattct cctgcttcag actcctgagt agcccagatc acgggcctcc     2940

accactatgc ttgactaata atttttcttt tttttttttg agatggagta tcgctctgtc     3000

gcccagactg gagggcagtg gcttgatctc agctcactgc aacgtcagct tcctgggttc     3060

aagcaattct cctgcatcag ccttccaagt agctgggatt aaaggcatgc accaccatgc     3120

ccagctaatt tttgtattta ttagtagaga cagggtttca ctatgctggg cagactagtc     3180

ttgaactcct gacctcaagt gatccacttg cctcggcctc ccaaagtgct gggattacaa     3240

gtgtgagcca ctgtgcctgg ccactaattt ttgtattttt tagtagagac agggttccat     3300

cgtgttggcc aggctggtct tgaactcctt acctcaagtg atccgcccac ctcggcctcc     3360

caaggttctg ggattacagg tgtgagccac agcggttggc ctagcctgca ctgtcttaag     3420

ggcctgttgg gcaggggagt tcaggttctc tcgtctctcc agattgatct tcacacattt     3480

gctaagtctc gtatcgtccc tgagcttggg agtcagggag cgctctgacc taagccctcc     3540

tgactttggg gtcaccatct ttccccagcc tctatgggca cactccctga attatctgtg     3600

gcttgagtgg agcaagcagg ggatgggatg aggggtggcg ggggagttcc cctcatccac     3660

ttcagccttc cagtctgctc ccccttcctg tacctctctc ttccagaacc ccaggccaag     3720

caccagagaa ggcctgggag tgagcaaggt gcccatgttg cttctgtgga tcatcctcct     3780

gcttgtacag ccctgggagg gcctaggaac gcccgcccct ctgctggagg gagccttttt     3840

acttccttgc agccctctga agataccagc gagtggggag cagagccagc agacggggtg     3900

ggccaattga tggggcgtgg tagggggtgt gtttgaggaa gggtcagcct ctttccctcc     3960

aagatctgat tctcctcctt acccctgaac tgtaggaaaa caaaaatgat gacaccctct     4020

acaccccaga tgatctctca gtgagtattg cattcgcttc tttctgcagt tgcaggtttt     4080

gagagaattc agtggtctcc atgtgtgagg gctgctgtgt gaccatatga atatgttgcg     4140

gggaggaagt agtgggacta tctcctgacc cagcccctag ccttgacaga tatattttgc     4200

tcactgctgt ctccaacacc tagaataggg aggtatataa taacaaatga tgatgatgac     4260

tacagctgca tgtaaatagt gtttactctg tgccaggtat tggtttaaat gctttaagta     4320

tgttagctta tttactctgt acaccaatcc tataagatag ataggaccac catgtatgga     4380

tgtgaatgtt gtacactgca caaggatccc acatctacaa agacagtact atattcacag     4440

gctggatatt gtagatttgc atatttgcca acttgcggca gatggcagta aagtatcttg     4500

ttctaataaa atcaagactt agaaggtaga aggaacttaa ggaaggtctt tttattttct     4560

tttttttgag acagggtctt gctctgtccc ctacgctgga gtgcagtggc acaatcacag     4620

ctcactgcag tcttgacctt ttaggctcaa gcaatcctcc cacctcagcc tccagagtag     4680

ctgggaccac atacacgtga caccacaaat agctaatggc taattttttt tttttttttt     4740

tgagacacag tgttgctctg ttgccagctg gagtgcagtg gcgtgatctc tgctcactgc     4800

aacctctgcg tcctgggttg aagcaattct tctgcctcag cctcccgagt agctgggact     4860

acaggcatgt gccaccatgc ccagctaatt tttgtatttt tagtagagac agggtttcac     4920

catgttggcc aggatgttct cgatctcttg acctcgtgat ccacctgcct caacctccca     4980

aagtgctggg attacaggcg tgagccaccg tgcccgacct tttttttttt tttttttttt     5040

ttgtagatat ggggtgtcgc tgtgttgccc aggctggttt tggacacctg ggctcaagtg     5100

atcttcctgc cttggcctct caaagagctg ggattacagg catgagccac tgtgcccagc     5160

tgagtgtctt tttctagctt gcacataagt acagcatggg atagtgtcag gccttacggt     5220

tgggattatc cagagcccta tttacagatg aggaaactga ggcccagaga actgaagggg     5280

tttgttccag gacacagata agaaatcttg ggagtgggga cttggactca tgcccttacc     5340

catagatacc aggtcacttt gtccctactg tgtgtcctgc tgagactcta ggctgctcca     5400

ggttggagct gtctgtgatt gggtttgagg agggaccatc tatgggaact gctgtgttcc     5460

agctacagta cctgctggat ctcctggggt cccggctgtg ggtggccagc cagggccctt     5520

gcctgtcctg tgaaggacat ccccagagac ctgtccccct cttggagtta ctacagggag     5580

cttgtgcttg gcaccctacc acagcctgag ctttggagga catgggctcc caggtacacc     5640

cagagaggct gggtagagag agggagggaa tagtcttcag ctccaactgc caaaccctaa     5700

gccttttctt ccctctaggc cagaggaccc cacctggagc cctagtagcc aaggggaaga     5760

gttaagaagg aggaaagtaa ggtgcgatct gaagtctctg acctcttggg cagggagttg     5820

gataaattgc cccacctgcc cccattctca ccctccttta gatactcttc tctcttcttc     5880

caggaaggga cagagaagtg cacaggtatt ctctaacctc atccctatac cttgagaaca     5940

gggagggtcc tgtggttcac atccctacat ccctggctac aaaaaattac cacttgaaga     6000

actttctttt cttttctttt ctgtttttga ggcagagtct cactctgttg cccaggctag     6060

agtgcagtgg catggtctca gctcgctgca acctccacct cctgggttca agtaattctc     6120

ctgcctcagc ctcctgagta actgggatta caggcacgcg ccactacacc tgactaattt     6180

ttgtattttt agtagagatg gggtttcaca atgttggtca cgctggtctc gaacgcctga     6240

ccttgtgatc tgcccacctc agcctcccaa actgctggga ttacaggcgt gagccaccgt     6300

gcccagccca ccacttggag aactttcaag taatactgat ggccagaccc cagcccagat     6360

aatttgataa ttggtctctg gtgaagcctg agcatctata ttatttttat tattatttag     6420

agacagggtt tcactatgct gcacaggctg taacttggca tctgcccata tatttttttg     6480

agacagggtc tcactctgtc acccaggctg gagtgcagtg gcatgatcaa aactcattgc     6540

aggctcgatc tttcaggctc aagtgactct cccacctcag tcccccaagt agctagcgct     6600

ataggcgcat gccaccacac tcagctaatt tttgtatttt ttgtagagat ggggttaccc     6660

tttattgccc aggctaatct tgaactcctg gctcaagcga tactcccccc ttggcctccc     6720

aaagtgctgg gattataggc atgagccacc acacctgaca tttttttttt ttttttgaga     6780

cagagtctcc ctttgtcacc caggctggag tgcaccggct ggtggactgg atggccacat     6840

ttccatcacc ccaaagcatt ccttctctct cttcccagtc aatttccacc tccctctcca     6900

gccccagaca tccactaatc tgcattgtct gtataggttg gttttgcttg ctctggagtt     6960

tcatatgaat ggaatcatgc tggacatctc ctgatgtctg gcttctttca ctcagcataa     7020

tgttttggag attcagtcat gggtgtattg gtagttgtta ctattctgtt gcatggatgg     7080

atgtaccaaa atttgttttt cttttgagac gagtctcact ctgttgccca ggctggagtg     7140

cagtggtgcg atctctgctc actgcaacct tcacctccct ggttcaagtg attctcctgc     7200

ctcagcctcc caagtagctg ggattacagg cgtgcgccac cacacctggc tatttttttt     7260

tttttttttt ttgtattttt agtagagatg gggtttcacc atattggcca ggctggtctt     7320

gaactcctga cttcgtgatc cgcctgcctt ggccttccaa agtgctggga ttacaggcgt     7380

gagtcactgc gcccggccct aatttttgtg tttccagttt agggctatta tgcaactctt     7440

tctttctaaa atattctcaa gtattctgat gtgctaccag agttgagttc agaaccacgg     7500

atccaccaag gaagaaactt ccatggctgg ggaaatgact gtgccctctt ttttctgcag     7560

ggaatggctt tctgcagcag tgtctgtagc gatttaatat gtagaatcct attttcttgt     7620

tgtttttttt tttgagacgg agtcttgctc ttttgtcaca gcaacctcca cctctcaagt     7680

tcaagagatt ctcctgccac agcctcccga gtagctggga ttacgggtgt gcgccactac     7740

gccacctggc taatttttgt attttttagt agagacaggg ttttaccatg ttggccaggc     7800

tggtcttgaa ctcctgacct caggtgatcc gcctgccttg gcctcccaaa gtgctgggat     7860

tacaggcgtg agccaccgcg cccggtggag aatcctttct ttttttgaga tggagtctag     7920

ctctgttgcc caggctggag tgcagtagca cgatctcggc tcactgcaag ctcggcctcc     7980

cgggttcacg ccattctcct gcctcagcct tacgtgtagc tgggactaca ggcgcccgcc     8040

accacgccca gctaattttt ttttgtattt ttagtagaga tggggtttca ccgtgttagc     8100

caggatggtc tcggtctcct gacctcgtga tccacccgcc tcggcctccc aaagtgctgg     8160

gattacagac gtgagccacc gcgcccggcc caggtgtgtc atacttatgt gagaaatttt     8220

accaatgtgt cctgaggctt cttttttttt tttttttttt tgagactgag tctcactctc     8280

gcccaggctg gagtgcagtg gcgcgatctc ggctcactgc aagctccgcc tcctgggttc     8340

acgccattct cctgcctcag cctcccgagt agctagaatc acaggcacat gccaccacgc     8400

ccggctaatt tttttgtatt tttagtagag acggggtttc accatgttgg ccagactggt     8460

ttcgaactcc tgacctcagg caatctgccc gccccggcct cccaatgtgt tgggattaca     8520

ggcatgagcc accgcgactg acatagactt ctgattttta aaatttcccc tatcaggtta     8580

atttttcaat ttttaaaaat ttaagtttta attttttttt tttttttttt ttagagacag     8640

ggtctctatt acccagtctg gagtgcagtg gtgcaatcat agctcactga agcctcaaca     8700

tgggttcaag tgatcctccc accttagcct ttggagtagc agggaccaca ggcacacgcc     8760

accacaccac attaaaaaaa acacaaaaat tggatacatg gggtctcaat ttgttgccca     8820

tgctagtctc aaatacctgg cctcaggtga tcctcccgcc tcagcctccc aaagcgctgg     8880

gattacaggc gaaggttcat ttttcatctc tccattacac ctgtccactc tgccatcact     8940

cgtcagccgt cattactaat agataaattc gcctttaaat gaacttagga agcctggaaa     9000

gaaaaatagg gacttgggcc gggcgcggca ggttatgcct gtgatctcag cactttggca     9060

ggacgaggcc ggaggatggc tttttagttt gagttagagg agtttgagac caggccgggc     9120

aacagcccga ctctaccaaa aaaaaaaaaa aagtacaaaa agaaagaaaa agaaggaaaa     9180

accagggctt cacggtcact cagacttggc gaggaggctt gggtctgccg ctttccactg     9240

agtttttctg agcttcagcg ttctctccaa aacggggata cggatctcct ggggatgctt     9300

tagagggcct aggagataaa gccttgtttc ttttataatt tgctattcgc tgatttcgcc     9360

gcctcctcgc agcttggcct accgcgctag tgttccggac taacgaacaa acggctcact     9420

aaattcaaac atgagtttca gcctggtcgc cgagccggcg ggtagaaaaa acctttcccc     9480

tcctaaccct ccgcagatgt cggccccgca ctccgcccag gccagccctg cctctctcaa     9540

gatggcgacc tggaagtgcg tcgcccgtgc cagccccgga aatctcgtgt taggcgaggt     9600

caacgggtag gttctcgcga gaggacccgt cagccccagt caggcgtc                  9648


<210>  21
<211>  12561
<212>  DNA
<213>  Homo sapiens

<400>  21
gaagaagctg gcccacgcat gcgctcttca aatttttgag acagtttacc cagaatgcag       60

tgctcaaagg aaacgcgtgc gcagtgtggt caggttgttt cgctgggtga gtaaaatgaa      120

atcttagagg cgttgtgggc tggcccagtt gatgacgtca ccataccaca gcttctagtg      180

ctattctgcg ccggtatccg accgccgggc gcggtggcgc gtgcctgtag tcccagctac      240

tcgggaggct gaggctggag gatcgcttga gtccaggagt tctgggctgt agtgcgctat      300

gccgatcggg tgtccgcact aagttcggca tcaatatggt gacctcccgg gagcggggga      360

ccaccaggtt gcctaaggag gggtgaaccg gcccaggtcg gaaacggagc aggtcaaaac      420

tcccgtgctg atcagtagtg ggatcgcgcc tgtgaatagc cactgcactc cagcctgggc      480

aacatagcga gaccccgtct cttttgaaca ataaatacgt taattttgga ctctcaagag      540

atgaatattc tcatagtctt ttttattgat taaacctttt actttctttt aattaaaacg      600

ttacacttgg gaaaggagtt tttcctcgac tcaccagtga cacctactgg aataaattta      660

caaaacaact taaaatcagc tgtaatgatc acgagtcaac ggtagggttt gcttttattt      720

tgttaaagag agtacgtttt caaatttatt tttttgacac actcctccaa gaaatacacc      780

tacaccattc caaaaaaaaa tgagattctt tggcatttag tgtatttgat tcttaaatgt      840

aattggctga atgtaaagta ataaacaagt aatgtgcagt gtatgttgct ttgaccagat      900

aatttggtga caaaacaagt aatgaaaagc aaatgcaaaa atgcaaaaaa ccaatgtcaa      960

taaacgaatt tctgctgaaa gatacctaca ttccatatgg tcatttataa tgcctccaga     1020

taaaactgct ctgaaatcaa agctttaact agatttataa aatgtagcac agggtgcaac     1080

aattccagaa acttttacat ataaactttt ataaattgaa atacaacact tctttaaggt     1140

atgttatgtc agggttctag tggggtcccc ctacccaatc attaagttag gcattgtatt     1200

atatgattaa ggaaggaggg gagtcagaga tttgtaaact agatataact tgctccttgc     1260

cctcaaaatt ttctaatctg tgggaaacag gattatctcc aagacttcaa catacaacgt     1320

ttgtgcacca acaacatatg tacagctaag gaaaatattc tgtattaaat catgggtgtg     1380

ctcatgaagt acgaaaggag ccaagaagag aaattaattc cagttcgagg tacatttgag     1440

agacctttga ggtagacctt gaagaatggg atttctacag gcagcacttg acagaaggga     1500

atgcctggtg aaaggaagcg cttgagccaa ggtaaggtga acaactttgt gtaactagaa     1560

tagaagatgg acaaaaggcc tagtgatagg aatgaaaagg tattttattt taaagcctca     1620

ttgggcaaga tccaatgtca agcttttaca actttcctat aatttatatc agtcactaat     1680

gtgtggtttc caaaagccat ttgcctctca aaagctaatc taacatttgt ccacactttc     1740

ttaggcctct tctagttggt ctccacaata tttaaaacat tacagtggtt ctgagatcaa     1800

ttccattaat atttttagta ctctgatata taagcctttg ggcctaaaga agtgaattca     1860

tttaggagag aaaaaaagac aaatgagaag caattagttg cacttcaaca atcttaatct     1920

gaatacttaa gtaattctta atacttattc tagtctatac attattctct ttgatagaga     1980

tattgcaaaa gtgcagctaa gacgtcgtac ttcctttcag ttttaagata atgtgacacc     2040

atctatccca aaccatgaaa ttatccattt ctttttcaac aaactgagaa cacagcttta     2100

aaagttcatt ttaactcggt gtttatcaag agcttttatg ttttgttttg ttttttttcc     2160

tttttttttg agacggagtc tcactctgtc gcccaggctg gagtgcaatg gcaccatctt     2220

ggctaactgc aacctgcacc tcctgggttc aagggattct cctgcctcag cctcccgagt     2280

tgctgaaatt acaggcacgt gccaccacac ccgtctaatt ttttacattt ttggtagaga     2340

tggggtttca ccatgttggc taggctggtc tcgaagtcct gacctcgagt aatccaccca     2400

cctcagcctc ccaaactgct gggattacag gagtgagcca ccacgcccgg cctaagagct     2460

tttatcttaa tcctgtagtc ttcttacagt ttctgagtcc tttttttttt tttttttttt     2520

ttttttgaga cggagtctgg agtctcgctc tgtgacccag gctggagtgt agtggtgcga     2580

tctcggccca ctgcaagctc cgcctcccgg gttcacgcca ttctcctgcc tcagcctccc     2640

gagtagctgg gactacagcg cccgccacca tgcccggcta atttcttttt gtatttttag     2700

tagagacagg gtttcaccct gttagccagg atggtctcga tctcctgacc tcatgatccg     2760

cccgcctcga cctcccaaag tgctgggatt acaggcgtga gccatcttag ttctctttta     2820

tacatgggtt tgaaatgctt cttcttttag aacacatttt cctttaatag gatatttatt     2880

gggtttgggt tctttgtttt ttaaaaaatg tacaatgaag tgcaaagaaa aagaaaaaaa     2940

aaagtgccat aatgtccttg cccagataac cctactaata tttttctttt gaaaaactaa     3000

aagtaatata catgtaagat cgaagcattc taacactgca aagtatagat cttattttta     3060

agtacattgg aataatatgc atgttaggac actattattc aagatgtctt taattttctt     3120

tctcaaatta ttcttacagt cttctgtgat catccatcca gaatttaatc atttaaaaac     3180

cttcatctta gacgtataca ctgctgatgg gaatgtaaat tacttcagca ctgtggaaag     3240

cagtttggtg atttcttaaa gaatttaaaa cagaactgtc atttgaccag caatcccatt     3300

actggatata tacccaaaag aatataaatc attctacagt aaaggcaaat gcatatgtat     3360

gttcatcgca gcactattca caatagcaaa cacactgaat caacctaaat agcaattttt     3420

taagcaacag tagactggat aaagaaaatg tagtacatat acactatgga atgctacaca     3480

gccacagaaa agaacaagat catgtcctgt gcaacagcat ggatggagct ggaggccatt     3540

atcctaaaca aactaacaca ggaacagaaa accaaacacc acgttctcac ttataagtga     3600

gagctaaaca ttgaatacac atggacccaa agaaagtaat agacagcagg gcctacttga     3660

gggtagaggg tgggaggagg gtgaggattc gaaaagtacc tattaggtac taagcttatt     3720

acctgggtga tgaaataata acccctgtga cacacaattt atctatagaa ccaacctgta     3780

catgtttcct tgaaactaaa agttttttta aaaacacctg gccaggcatg gtggctcacg     3840

cctgtaatcc cagcactttg ggaggctgag gcaggcagat cacaaggtca ggagttctag     3900

accaacctgg ccaatatggt gaaacccggt ctccactaaa aatacaaaaa ttagccaggc     3960

atggtggcgg gcgcctgtag tcccagctac tctggaggct gaggcaggag aatcgcttaa     4020

acccaggagg cagagcttgc agtgagccga gattgcgcca ctgcactctg gcctgggcaa     4080

cagagtgaga ttccgtctca aaaaaaaaca aaaaacaaaa aaacctgcat cgctcttgag     4140

ttactttcaa ttttggaacc tttgggaata gaatcatact tttcctctaa actttacaaa     4200

acctatttta ccatagacag agtctaaaat acatgtttcg catgtttggt tattacaata     4260

tgcacacttc agtatcatgc cccggttttt tccagttggt tagaattagg tctttttttt     4320

ttttttcttt ttgagacgga gtctcactct gtcacccagg ctggagtgca gtagggccat     4380

ctcggctcac tgcaacctcc acctcccagg cttaagcgat tctcctgcct cagtctcctg     4440

ggtagctgag atcacaggcg tgtgccacca ctcccagcta atttttgtgt ttttagtaaa     4500

gacggggttt tgccatgttg gccaggctgg tctcgaactt ctggcctcta gtgatcttcc     4560

ccctcagcct cccaaagtgc tgggattaca ggcatcagcc accacgccca accagaatta     4620

ggtctttatt aataattatt aacccttcaa aaaagcccag ttgttcaata gtgttatgtg     4680

tttgtccata tcgattttag caaatattaa tattttaatt aactgtacat attatatttt     4740

aaagtaaaac atacatactt caggaaaggg gactcagaaa aaggaaaaaa atacatacat     4800

acatgcatac attaaatata ttatcaaaag taagtctttc tccaacccta gacccctatt     4860

ttcccagtct ccctgtccaa accaacaagt tagcagtttt tagaggtttt ctgtttgttt     4920

gtttgtttgt ttgtttgttt gttttcacag agtctcactc tgttgcccag gctggagggc     4980

aatggtgcag tgcaatctca atctcagctc agggcaacct ccacctcccg gctcaagcga     5040

ttctcctgcc tcagcctccc aagtagctgg gattacaggc gcatgtcacc acacccagct     5100

aatttttgta tttttagtag acacggagtt tcaccatgtt ggccaggctg gtcttgaact     5160

cctgacctca ggtaatccac ccgcctcagc ctcccaaagt gctgggatta cagggatgag     5220

ccaccatgcc tggcccaatt tgattttttt tttttttttt ttgagatgga gtcttgctct     5280

gtcagccagg atggagtgca gtggcgtgat ctcggctcac tgcaacctct gcttcccggg     5340

ttcaaacgat tcacctacct cagcctcccg agtagctggg attacaggcg cccaccacca     5400

tggctggcta attttttgtg tttttagtag agacagggtt tcaccgtgtt agccaggatg     5460

gtctcgatat cctgacctca tgatccgcct gcctcggcct cccaaagtgc tgggattgca     5520

ggcatgagcc accacgcccg gccccaattt gattttttaa agtccactta gcaagattca     5580

atttgatttt ctgatgagac agagcgtatt ttcctatgtt tataagccag acatatatct     5640

ttatctggga acttttttga gtccacagcc caattttttt aatccattgg taagctagtt     5700

tatatattta taaatactta tgtataagga aatacacctt tgaccttcat ataagatgca     5760

aagttatttt ctttgccacc atcccagatt cttacttatt ttttaaattt gtttatggta     5820

tatttttcca tgcaaaaagt tttttttttt attttttatt tttggctagt caagtgaagc     5880

agtgggagta gagaaggaac aaataaatct gtaactggtt gtaattaatt agttgtaaac     5940

tccactgcac tcggaccagc accatgcaaa aagttttaaa gtctatgttt tttttttttt     6000

ttttttttga gacggagttt cactcttgtt gcccaggctg aagtgcagtg gcgtgatctt     6060

gcctcacctc aacctctgtc tcccgggttc aagcgattct cctgcctcag cctcccgagt     6120

agctgggatt acaggcatgc gccaccaccc ccagctaatt ttgtattttt agtagagacg     6180

gggtttctcc atgttggtca ggctggtctt gaacccccgc cggccaaaag tctatgtatt     6240

aaaattaact tgccgggcgc agtggctcac acctgtaatc ccagcacttt gggaggccga     6300

gacgcgtggg tcacctgagg tcaggagttc gagaccagcc tgaccaacat ggagaaacca     6360

cgtgtctacg aaaaacacaa aattagcccg gcgtggtggt gcatgcctgt aatcccagct     6420

actcaggagg ctgagacagg agaatcgttt gaacccagaa ggcggaggtt gcagtgagcc     6480

gagattgcgc cactgcactc cagcctgggc agcaagagcg aaaccgcatc tcaaaaaaaa     6540

aaaaattaaa attaacttgt cacactactg cctttaggtt ttgcatcaaa attctttaaa     6600

ggttacatgt gttttcctgt gatattttta aagtttttat ttaaatcttg aaaccaccta     6660

aaatttatgt cactgttccc caggaatgaa ggagaaattc agcttttttc tcctcccaaa     6720

tggctactta tcccaacaca agccgtatta attgcatgta aggctgctgt attctagcac     6780

aatgcatgct ttcagaaata tttgctaaat gaataaatga aaagcagtat ttgtttattc     6840

tttctacaaa tatgcattga gtaccgactg catataacca ctatgctagg ctttgcatat     6900

aacagtaatg actcagaagc caggaagcat atcatctagc ggtgaagata agcattaaat     6960

aagtaatcat atagcaatat tttgaacagg ataaaattcc tcttacagtc aacactcaaa     7020

tgtgctggat aaaatatgac attttggccg ggcgcagtgg ctcatgcctg taatcccagc     7080

actttgggag gccaaggtag gtggatcacc tgaggttagg agtttgagac cagcctgact     7140

aacatggtga aactccgtct ctactaaaaa tgcaaaagtt agccaggtgt agtgtaatcc     7200

cagctactca ggaggctgag gcaggagaat cgcttgaacc tgggaagtgg aagttgcaat     7260

gagccgagat cacggcatcg cactccagcc tgggcgacag agcaagactc tgtctcaaaa     7320

aaaaaaaaaa aaaaaaaaaa gacgttttaa aatgcagagg tgagctcaca agaaaggggt     7380

atactggggg caggtgctaa gtgggaactg aaaaaacaga ggctgtcctg gggcaatctg     7440

tcctcctaag taatattaca tataacctgg attccaaagg gagcaagaga caagcctttg     7500

ggcaactgta tttaatcaaa ttgtgatgag tagaaatcca tgaaggtttt tgggagaaat     7560

taaatacagc atctgagact tgagttctag tcctgtttat tctaacattg actgtctatg     7620

aggtcatggt caaatagtgt acctttactc ttaattccat tccctcttgt gcaaaatgag     7680

agaattgaag taaaatatct ataaacgaca tttcagctct aaaacttgag gattctatga     7740

taggatatcc ctctacaaat ttaatttggc tgcagtatgg atggtggatt attacaacag     7800

cctcctaact gatacatctg ctttcaggct tgctctacct ccaaaatcat ctttttactg     7860

accacaagaa cctttcctga tcaggtctga attttatccc gcttaaaatt tttcaaaggt     7920

tttccagaac tttcagagcc tgggggacag ggtgtgaacc tgtctcaaaa aaaaaaaaaa     7980

tcctaagtgt taaatgaatg aataaatgta ttgaagcaag aagacctggt aaatttagca     8040

acagctctgt agcaaagtaa tgcagctctg aattgatacg gcagtgctaa gaatggaaag     8100

gtggtcattc attagtaaat aatcgtggaa acacaatcta taagacattc aaagagtgtc     8160

actgatgaaa ggcagaactt agaggagtga aagttgcaga taccaggatg aaatcacttt     8220

tgtcagaacc aaacaaaata gggccagaaa ggcaaaaagg aaagggctca tgtttgtatg     8280

tctgagataa gaactgtttc tgaagacttt ctaaaaactc cacaagagat cacttcacat     8340

ccttcacaca tgtcctcctt tgcacagttg gcaggtttca gacatataca tatatttcta     8400

tgacaaggct tatcattctt taggactgca gtaatttaga taagaagctc tcaaaagaac     8460

acttgcccag taacagcatc tccaccaatg aactgatgac agctctggct ctgagcctct     8520

ggaaccaatg aactctgttc attgaacaga actcttgctt ctgtttccaa gcagctttat     8580

ttgaacttgc cctttttgcc aataaaagct tccttttacc cttccctcac tggacgtact     8640

tttggcttgc catttcgtgc atcctgaatt ctaatattct cttcccattt ctgaataaat     8700

tcaacatatt tggagatatt tttctccagt cttttttttc ccttttttga gactgaaaga     8760

ggtctgatgc ttaggtgcat attttttaac tatttagctg tattgagtct tagatgatgt     8820

ttaccactaa aaaaaaaact aactccaaca tctggatcaa atgtgctagg gcaagcaagt     8880

ctacactgtc catagattgt gacctcgttc tttaagaatc tgatgtgggt ggggcatggt     8940

ggctcatacc tgtaatccga gcactttggg aggctgaggc aggaggacag cttgaggtca     9000

ggagttcaag accagactag gcaacatagc aagaaccccc atctctagca aaaagtaaaa     9060

aaacaaacaa aaaaaccaca cacatctggc catggtggca cgcacctgta gtctcagcta     9120

ctcgggaggc tggggtagga ggatggcttg agcccaggag tttgaggttg cagtgagcta     9180

tgaatgttgc cactgcactc cagcctgggt gaaaccctgt ctccaaaact aagctaaact     9240

aaaaaaaaaa aaattctgat gtgactgtga ttttactagc tcaaacataa tgagctacaa     9300

agtgagcaaa gttcactatg actacaaatg aaaagttgaa agaaatccat tgtcggcagg     9360

gcgcggtggc tcacgcctgt aatcccagca ctttgggagg ctggggcggg tggatcacca     9420

gaggtcagga gttcgagacc agcctgacca atatggtgaa accccgtctg tactaaaaat     9480

acaaaaatta cctgggcatg gtgacaggca cctgtaatcc cagctactca ggaggctgag     9540

gcaggagaat cgcttgagcc ggggaggctg aggttgcagt gaggcgagat cgtgccactg     9600

cactccagcc tgggcaacag agcggaagga aggaagaaat gaaggaggga gggagggagg     9660

gagggaggga accattatct gttgaatgcc tagtatgtgc cagaaagcca gggaaataaa     9720

tgaaaagtgc aattggagct tgcaaaaagg aaggtcaaga tgctaaagaa ggtttagcgg     9780

aaactgaact gggatttgat catattaatt aatatgaaca aaaagagaga aaagaatgta     9840

gtttgtaggc caggtagaag aagaactaat tttatagaag aaaaacaaat ctaaatgtta     9900

tatcttttat ttctcttgtc aaaaacttgt agtccaatta tttttaactc cttatgtatt     9960

tccattttca gtctgtctac aaggaaaact gactcgaggt aattaaggat agagatcaag    10020

gggcagattt tatttgtatg gtggtaaagt tcaaagggct ctttgctcca caatcgatcc    10080

actaagacca aaaactttag gtgtactcta gagtgtcaca tccaagtatt taaaccatta    10140

aatttgggtg gacaaagggg aggatgtgga aagggaaatg agataccaaa aactgataga    10200

tgtttaaaaa agaggtagtt tggaaactac cttttttaag actgacaatt aggaagatac    10260

atttttggca gtatatacca ctgtttcact ctaaaatcac cgttgaactg ttatgtaact    10320

ttcatctatt tatttaatta ctgaatccat gcttcaacaa cccaagccta agtaacacca    10380

aataaaggac tgagattgag gctttttttt tttttttttg agacaaggtc tcgctctgtc    10440

gcccaggctg gagggcagtt cttcgctcac tacctctgcc tcctaggctc aagctgggac    10500

tacagacgcg cgccgccccg cccaactaat tttttcttct tctttttttt tttttttttt    10560

gagagtctcg ctctgtcgcc caggctggag tgcagtggca ctatctcggc tcactgcaac    10620

ctccgtctcc caggttcaag cgattctcct gcctcagctt cccgggtagc tgggactaca    10680

ggtgcgcgcc aacactctgt ctaatttttg tatttttagt agagacgggg tttcaccatg    10740

ctggccaggc tggtctccaa ctcccgacct caggcgattc tcccgcctcg gcctcccaaa    10800

gtgctgggat tacagtcgtg agccaccgcg cccggcctag ttaatttttt aatttaattt    10860

ttttgtggag acgaggtctc actattgccc aggctaatct cgaacttctg ggctaagcga    10920

tcctcctgcc tcgagcctcc caaattgttg ggcttacagg cgtgagccac cgcacctggc    10980

ggaacatttc tactctaatg aaaattataa cagtttttac agttttccta gctcccaact    11040

gtacctataa gttcagagtc catttaatgt acttgtaata attcaggctg gtgttttatt    11100

atcttttcta cattattacc ctctcaaaga acaaaagcag gtaactccta taaagtctaa    11160

tagtctgaaa attgtagtgt ccgttttctc tttagccata aagttttgct taaatgctga    11220

gtcgcgtttt aatgctctac tagatgtaca tataagaata ctaaatggag ggaaagtaat    11280

ttcttttttt tttttgagac ggggtcactc aggctggagt gccagtgcgc gattacagct    11340

caccggagcc tctcgacctc cccaggctca agtgatcctg ccacctcagc ctccccaata    11400

gctgggacta cagacacgcg ccaccacgcc cggctaattt ttttgtattt ttcttagaga    11460

ctgggttttg ccatgttgcc caaactggtc ttgaactcct gggctcaagc gacctgcctg    11520

cctcagcccc gcaaagtgct gggattacag gcgtgagcca ccgcgcccgg ccataatttt    11580

atcttaatca cttttttcca ggaactatta cgtttcaaag aatgaggaat taactgacaa    11640

cacttcaggt tcaacatgta aatagggacg ctcatttgag aataaatcac attttgtcac    11700

agttgtattg aaaaatcggt atttctgaac gtcattttac cattacggaa gtataactca    11760

gacacaataa aatgtttaat atacggctag gattaggtta aggtgagaga ggcgcctaga    11820

gcacaaattt taaggaggca agaccacgac cccgaccgtg agcgcctgct taacatttgc    11880

tccccaggcg cttcccactc cccagccggg ccccgtccta gttcaatcaa tcaagaaaat    11940

caagagtacg aaggccttgt gcggtctgga cggtctttcc acgtctcagg tgcagttaag    12000

ccagtcacac tccatccacc tacccgccat gaaaaattat ttgttcagca ggaattgcca    12060

agtcaaatac agccatataa agcccccctt cgacgtgcca ggtgtgcctc cggagagcag    12120

ccaccaaaac caccagcagc ccgtccgcgc cgggaaatgc gccctcgctg gcttacgggg    12180

ccactcagac agttctaagt gcctttccct gtaacgcaga ggcacacctg ccttccctcg    12240

ggaaacagcg gcccgacgtg cgcccgcaac gcgtaaagcg tcaacagctg aaaccctcgg    12300

aatcctcccc gaacagaaac aaccaccgct gccagctgcg cgctcggggg aaaagacgtt    12360

gcgcccccgc cgactgccgg tttcccgggc gcgagcccgg atccaggtgg tcagtcccgg    12420

tacgcaacca cggcgagaac ccggccctgc taagggagaa gggaagccgt ttcccgcggg    12480

cttcatacag acacggtgct aagacagccc gagtcgcgga ccagtccaac aggcaggcag    12540

atcagtgggc agcccgcgtg c                                              12561


<210>  22
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide RNA

<400>  22
gggcgugucu cggcaccccu guuucagagc uaugcuggaa acagcauagc aaguugaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u               111


<210>  23
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide RNA

<400>  23
gagcucccgg guuccggagc guuucagagc uaugcuggaa acagcauagc aaguugaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u               111


<210>  24
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide RNA

<400>  24
ggggcggcua cucgaguuca guuucagagc uaugcuggaa acagcauagc aaguugaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u               111


<210>  25
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide RNA

<400>  25
gaauuccggg ucaaugggcg guuucagagc uaugcuggaa acagcauagc aaguugaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u               111


<210>  26
<211>  3411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression construct

<400>  26
gtggtggcgg gcgcctgtag tcccagctac tcgggactac aggagaatcg cttgaaccca       60

agaggcggag tgttgcagtg agccaagatc gctccactgc actccagtct ggcgacagag      120

cgagaccccg tcttaaaaaa aacaaaacaa aacaaaaaaa aaacctttgc tttcccgcct      180

tccaagagga aggggcgcat ctctgaggaa acaagcccgg ggaacccgca gcccggacgg      240

catcctctca tctacacaac ccgaggacat ctccctcagc tcccagagga cggcggacca      300

tggtcaaggt cctctttccg gcctttcaca actccaagcc ccgccccaca aaaccccctg      360

cagtcctacc aagtcactcc catggcgtcg ggccaggaag gtggcagaat cacacagtag      420

aaacgcaggg ttccctgtcc gcccacagaa actccttcag ttccccaaca caaccttctg      480

tctcagaagg gactccggaa atacgtaaaa acagagcgcc gggtccacgc cttccccaag      540

gaatggggcg cgtctcggca cctaggctag cgatcctcta gattcgagtt tactccctat      600

cagtgataga gaacgtatga agagtttact ccctatcagt gatagagaac gtatgcagac      660

tttactccct atcagtgata gagaacgtat aaggagttta ctccctatca gtgatagaga      720

acgtatgacc agtttactcc ctatcagtga tagagaacgt atctacagtt tactccctat      780

cagtgataga gaacgtatat ccagtttact ccctatcagt gatagagaac gtataagctt      840

taggcgtgta cggtgggcgc ctataaaagc agagctagct gcagtaacgc cattttgcaa      900

ggcatggaaa aataccaaac caagaataga gaagttcaga tcaagggcgg gtacatgaaa      960

atagctaacg ttgggccaaa caggatatct gcggtgagca gtttcggccc cggcccgggg     1020

ccaagaacag atggtcaccg cagtttcggc cccggcccga ggccaagaac agatggtccc     1080

cagatatggc ccaaccctca gcagtttctt aagacccatc agatgtttcc aggctccccc     1140

aaggacctga aatgaccctg cgccttattt gaattaacca atcagcctgc ttctcgcttc     1200

tgttcgcgcg cttctgcttc ccgagctcta taaaagagct cacaacccct cactcggcgc     1260

gccagtcctc cgactcgaga gcgctgccac catggtgagc aagggcgagg agctgttcac     1320

cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt     1380

gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac     1440

caccggcaag ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca     1500

gtgcttcagc cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc     1560

cgaaggctac gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg     1620

cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga     1680

cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa     1740

cgtctatatc atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca     1800

caacatcgag gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg     1860

cgacggcccc gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa     1920

agaccccaac gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat     1980

cactctcggc atggacgagc tgtacaaggg atccggagcg actaacttct ccctgctgaa     2040

gcaggccggc gatgtagaag agaacccggg ccctaccgag tacaagccca cggtgcgcct     2100

cgccacccgc gacgacgtcc ccagggccgt acgcaccctc gccgccgcgt tcgccgacta     2160

ccccgccacg cgccacaccg tcgatccgga ccgccacatc gagcgggtca ccgagctgca     2220

agaactcttc ctcacgcgcg tcgggctcga catcggcaag gtgtgggtcg cggacgacgg     2280

cgccgccgtg gcggtctgga ccacgccgga gagcgtcgaa gcgggggcgg tgttcgccga     2340

gatcggcccg cgcatggccg agttgagcgg ttcccggctg gccgcgcagc aacagatgga     2400

aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg ttcctggcca ccgtcggagt     2460

ctcgcccgac caccagggca agggtctggg cagcgccgtc gtgctccccg gagtggaggc     2520

ggccgagcgc gccggggtgc ccgccttcct ggaaacctcc gcgccccgca acctcccctt     2580

ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag gtgcccgaag gaccgcgcac     2640

ctggtgcatg acccgcaagc ccggtgcctg aggcacccct cgatgacgcc tccactgaca     2700

tcatctgcgg attcccgccc cgaggtttct aaatccagac attcccgttt ggctgagcac     2760

tctaggccta catccatgaa gctaggagag cgacactcaa agactgcact attgagagaa     2820

gctaacgtta aaggcagtga atatattcgg gagtacagct ccggaacgcg tgagctcttt     2880

tagtgggagg ggcggcgctg atggcgcttc tggcctccga atgctagggg gcgctgtgat     2940

cgccgggcgg cctcttgggc gctgggagtc caccgcgcaa gcgcatcctg gcctttcttc     3000

agtccccacg tgcgatcctt cccggcaact ttttcgagaa aaatgcccaa attcaaggcg     3060

gcccgtgggg tggggggtca ggaaaaacat gcgcccctgg ccgatcagat cctggctggg     3120

aatgcggtgc gggcgggggt ccgggagaag cggcggggtc gcgggacagg agaagcggag     3180

gaagagtatg tggggccccg gctgagccga cggattttgc agcaagcacg gcagcaacag     3240

gaggaactcg aggccgagca tgggactggg gacaagcccg cggcgccgcg ggaacgcacc     3300

acgcggctgg gtgagtgtct gggatgaggt ccgaggaaga cagtggccag tagtggggcg     3360

gggtgggcag ctaaaaagtg tctggcaggg gaattgcttc gagtcaacaa a              3411


<210>  27
<211>  3411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression construct

<400>  27
gtggtggcgg gcgcctgtag tcccagctac tcgggactac aggagaatcg cttgaaccca       60

agaggcggag tgttgcagtg agccaagatc gctccactgc actccagtct ggcgacagag      120

cgagaccccg tcttaaaaaa aacaaaacaa aacaaaaaaa aaacctttgc tttcccgcct      180

tccaagagga aggggcgcat ctctgaggaa acaagcccgg ggaacccgca gcccggacgg      240

catcctctca tctacacaac ccgaggacat ctccctcagc tcccagagga cggcggacca      300

tggtcaaggt cctctttccg gcctttcaca actccaagcc ccgccccaca aaaccccctg      360

cagtcctacc aagtcactcc catggcgtcg ggccaggaag gtggcagaat cacacagtag      420

aaacgcaggg ttccctgtcc gcccacagaa actccttcag ttccccaaca caaccttctg      480

tctcagaagg gactccggaa atacgtaaaa acagagcgcc gggtccacgc cttccccaag      540

gaatggggcg cgtctcggca cccctcgatg acgcctccac tgacatcatc tgcggattcc      600

cgccccgagg tttctaaatc cagacattcc cgtttggctg agcactctag gcctacatcc      660

atgaagctag gagagcgaca ctcaaagact gcactattga gagaagctaa cgttaaaggc      720

agtgaatata ttcgggagta cagctccgga acgcgctagg ctagcgatcc tctagattcg      780

agtttactcc ctatcagtga tagagaacgt atgaagagtt tactccctat cagtgataga      840

gaacgtatgc agactttact ccctatcagt gatagagaac gtataaggag tttactccct      900

atcagtgata gagaacgtat gaccagttta ctccctatca gtgatagaga acgtatctac      960

agtttactcc ctatcagtga tagagaacgt atatccagtt tactccctat cagtgataga     1020

gaacgtataa gctttaggcg tgtacggtgg gcgcctataa aagcagagct agctgcagta     1080

acgccatttt gcaaggcatg gaaaaatacc aaaccaagaa tagagaagtt cagatcaagg     1140

gcgggtacat gaaaatagct aacgttgggc caaacaggat atctgcggtg agcagtttcg     1200

gccccggccc ggggccaaga acagatggtc accgcagttt cggccccggc ccgaggccaa     1260

gaacagatgg tccccagata tggcccaacc ctcagcagtt tcttaagacc catcagatgt     1320

ttccaggctc ccccaaggac ctgaaatgac cctgcgcctt atttgaatta accaatcagc     1380

ctgcttctcg cttctgttcg cgcgcttctg cttcccgagc tctataaaag agctcacaac     1440

ccctcactcg gcgcgccagt cctccgactc gagagcgctg ccaccatggt gagcaagggc     1500

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc     1560

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg     1620

aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg     1680

acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc     1740

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc     1800

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag     1860

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     1920

tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac     1980

ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag     2040

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag     2100

tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     2160

accgccgccg ggatcactct cggcatggac gagctgtaca agggatccgg agcgactaac     2220

ttctccctgc tgaagcaggc cggcgatgta gaagagaacc cgggccctac cgagtacaag     2280

cccacggtgc gcctcgccac ccgcgacgac gtccccaggg ccgtacgcac cctcgccgcc     2340

gcgttcgccg actaccccgc cacgcgccac accgtcgatc cggaccgcca catcgagcgg     2400

gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc tcgacatcgg caaggtgtgg     2460

gtcgcggacg acggcgccgc cgtggcggtc tggaccacgc cggagagcgt cgaagcgggg     2520

gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga gcggttcccg gctggccgcg     2580

cagcaacaga tggaaggcct cctggcgccg caccggccca aggagcccgc gtggttcctg     2640

gccaccgtcg gagtctcgcc cgaccaccag ggcaagggtc tgggcagcgc cgtcgtgctc     2700

cccggagtgg aggcggccga gcgcgccggg gtgcccgcct tcctggaaac ctccgcgccc     2760

cgcaacctcc ccttctacga gcggctcggc ttcaccgtca ccgccgacgt cgaggtgccc     2820

gaaggaccgc gcacctggtg catgacccgc aagcccggtg cctgagcgcg tgagctcttt     2880

tagtgggagg ggcggcgctg atggcgcttc tggcctccga atgctagggg gcgctgtgat     2940

cgccgggcgg cctcttgggc gctgggagtc caccgcgcaa gcgcatcctg gcctttcttc     3000

agtccccacg tgcgatcctt cccggcaact ttttcgagaa aaatgcccaa attcaaggcg     3060

gcccgtgggg tggggggtca ggaaaaacat gcgcccctgg ccgatcagat cctggctggg     3120

aatgcggtgc gggcgggggt ccgggagaag cggcggggtc gcgggacagg agaagcggag     3180

gaagagtatg tggggccccg gctgagccga cggattttgc agcaagcacg gcagcaacag     3240

gaggaactcg aggccgagca tgggactggg gacaagcccg cggcgccgcg ggaacgcacc     3300

acgcggctgg gtgagtgtct gggatgaggt ccgaggaaga cagtggccag tagtggggcg     3360

gggtgggcag ctaaaaagtg tctggcaggg gaattgcttc gagtcaacaa a              3411


<210>  28
<211>  3393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression construct

<400>  28
tccggcctcg caaccgacca ccccttctgc aggagaggta cataatggtc gcaaagagca       60

ggcgaaccgg gcagagatcg ctcgctcgct cgcagactga gcgaatccgg actcacccgt      120

ctccttcgcc aagtgataaa acttgtctcg tcggctcttg ccaactttgc ccttcttgcc      180

catggtggaa agggggagta tccctcaatc tggggagaaa gtagaagttg ggaacgtctc      240

tttccggagc accagattcc acttccagtt tcccacttcc agtttcccac ttcccgcagc      300

aattccaccc cgcgcccctc tccgcacact acctagaccc agagccgctt tctccacact      360

tggaaccgca caagtatgca gctaactact tccgcttccg cttgcgtccc ctgcgtccct      420

ggctcgaggt tttccgccat tttgagtgtg gccctagatt gttctcaata ctctgtcctt      480

gggttttgta agttgaaagt tgagactagg aaggcatatc acaagaacta taaacagagt      540

ttcaatgagg caacactgag gaggagttct actccttcct catccccttc caaagcacct      600

gaactctagc taggctagcg atcctctaga ttcgagttta ctccctatca gtgatagaga      660

acgtatgaag agtttactcc ctatcagtga tagagaacgt atgcagactt tactccctat      720

cagtgataga gaacgtataa ggagtttact ccctatcagt gatagagaac gtatgaccag      780

tttactccct atcagtgata gagaacgtat ctacagttta ctccctatca gtgatagaga      840

acgtatatcc agtttactcc ctatcagtga tagagaacgt ataagcttta ggcgtgtacg      900

gtgggcgcct ataaaagcag agctagctgc agtaacgcca ttttgcaagg catggaaaaa      960

taccaaacca agaatagaga agttcagatc aagggcgggt acatgaaaat agctaacgtt     1020

gggccaaaca ggatatctgc ggtgagcagt ttcggccccg gcccggggcc aagaacagat     1080

ggtcaccgca gtttcggccc cggcccgagg ccaagaacag atggtcccca gatatggccc     1140

aaccctcagc agtttcttaa gacccatcag atgtttccag gctcccccaa ggacctgaaa     1200

tgaccctgcg ccttatttga attaaccaat cagcctgctt ctcgcttctg ttcgcgcgct     1260

tctgcttccc gagctctata aaagagctca caacccctca ctcggcgcgc cagtcctccg     1320

actcgagagc gctgccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc     1380

catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg     1440

cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct     1500

gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg     1560

ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt     1620

ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa     1680

gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga     1740

cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat     1800

ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga     1860

cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt     1920

gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga     1980

gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat     2040

ggacgagctg tacaagggat ccggagcgac taacttctcc ctgctgaagc aggccggcga     2100

tgtagaagag aacccgggcc ctaccgagta caagcccacg gtgcgcctcg ccacccgcga     2160

cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc gccgactacc ccgccacgcg     2220

ccacaccgtc gatccggacc gccacatcga gcgggtcacc gagctgcaag aactcttcct     2280

cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg gacgacggcg ccgccgtggc     2340

ggtctggacc acgccggaga gcgtcgaagc gggggcggtg ttcgccgaga tcggcccgcg     2400

catggccgag ttgagcggtt cccggctggc cgcgcagcaa cagatggaag gcctcctggc     2460

gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc gtcggagtct cgcccgacca     2520

ccagggcaag ggtctgggca gcgccgtcgt gctccccgga gtggaggcgg ccgagcgcgc     2580

cggggtgccc gccttcctgg aaacctccgc gccccgcaac ctccccttct acgagcggct     2640

cggcttcacc gtcaccgccg acgtcgaggt gcccgaagga ccgcgcacct ggtgcatgac     2700

ccgcaagccc ggtgcctgag ctagaagccg cccctcccat catggttccc ttagtgtggt     2760

ctcgccgcac aacccgccca tgtacacgga attcttctct gcctggtctt caggtcccaa     2820

tcctccgctt ccgcgcttgc gcgccaagac ggctcggatg ccggcggtct ctgctgaaga     2880

gagaagatgg cgcttgacgg accagagcag gtatggcggg tgcagtggcg gcccggcagg     2940

ttacggggct gggtgcggag cgagcgtgat ctgagtggag agcgggccgg ggcaggagcg     3000

tcgggtgggt cggaggtgcc tggaccagtc catgctggac gctgcctgcg accggatctg     3060

ctgtgtcagc gccgccctcg gtgagtcagg gcaaggctgg gagaggaaga cgcggtagaa     3120

gcggagtgag tgagggaagc gatgggcgcg ggaatggccg gcccacgggt cgcaggagac     3180

gggacgccag tcctttggct ccgttccgct ggctccttcg tcagtactga cacctcgggc     3240

ttgtagagca cttcacgcag tgcaaagcgc cccccgtcta tatcatatcg cctctcggtc     3300

ctcctaaaag tcgtatgagg taggcggcgt tcccattctt ttattttagt cctgggaaaa     3360

tggagggttc caagggaggg agggattaga acc                                  3393


<210>  29
<211>  3393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression construct

<400>  29
tccggcctcg caaccgacca ccccttctgc aggagaggta cataatggtc gcaaagagca       60

ggcgaaccgg gcagagatcg ctcgctcgct cgcagactga gcgaatccgg actcacccgt      120

ctccttcgcc aagtgataaa acttgtctcg tcggctcttg ccaactttgc ccttcttgcc      180

catggtggaa agggggagta tccctcaatc tggggagaaa gtagaagttg ggaacgtctc      240

tttccggagc accagattcc acttccagtt tcccacttcc agtttcccac ttcccgcagc      300

aattccaccc cgcgcccctc tccgcacact acctagaccc agagccgctt tctccacact      360

tggaaccgca caagtatgca gctaactact tccgcttccg cttgcgtccc ctgcgtccct      420

ggctcgaggt tttccgccat tttgagtgtg gccctagatt gttctcaata ctctgtcctt      480

gggttttgta agttgaaagt tgagactagg aaggcatatc acaagaacta taaacagagt      540

ttcaatgagg caacactgag gaggagttct actccttcct catccccttc caaagcacct      600

gaactctaga agccgcccct cccatcatgg ttcccttagt gtggtctcgc cgcacaaccc      660

gcccatgtac ctaggctagc gatcctctag attcgagttt actccctatc agtgatagag      720

aacgtatgaa gagtttactc cctatcagtg atagagaacg tatgcagact ttactcccta      780

tcagtgatag agaacgtata aggagtttac tccctatcag tgatagagaa cgtatgacca      840

gtttactccc tatcagtgat agagaacgta tctacagttt actccctatc agtgatagag      900

aacgtatatc cagtttactc cctatcagtg atagagaacg tataagcttt aggcgtgtac      960

ggtgggcgcc tataaaagca gagctagctg cagtaacgcc attttgcaag gcatggaaaa     1020

ataccaaacc aagaatagag aagttcagat caagggcggg tacatgaaaa tagctaacgt     1080

tgggccaaac aggatatctg cggtgagcag tttcggcccc ggcccggggc caagaacaga     1140

tggtcaccgc agtttcggcc ccggcccgag gccaagaaca gatggtcccc agatatggcc     1200

caaccctcag cagtttctta agacccatca gatgtttcca ggctccccca aggacctgaa     1260

atgaccctgc gccttatttg aattaaccaa tcagcctgct tctcgcttct gttcgcgcgc     1320

ttctgcttcc cgagctctat aaaagagctc acaacccctc actcggcgcg ccagtcctcc     1380

gactcgagag cgctgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     1440

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     1500

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     1560

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     1620

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     1680

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     1740

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     1800

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     1860

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     1920

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     1980

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     2040

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     2100

tggacgagct gtacaaggga tccggagcga ctaacttctc cctgctgaag caggccggcg     2160

atgtagaaga gaacccgggc cctaccgagt acaagcccac ggtgcgcctc gccacccgcg     2220

acgacgtccc cagggccgta cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc     2280

gccacaccgt cgatccggac cgccacatcg agcgggtcac cgagctgcaa gaactcttcc     2340

tcacgcgcgt cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc gccgccgtgg     2400

cggtctggac cacgccggag agcgtcgaag cgggggcggt gttcgccgag atcggcccgc     2460

gcatggccga gttgagcggt tcccggctgg ccgcgcagca acagatggaa ggcctcctgg     2520

cgccgcaccg gcccaaggag cccgcgtggt tcctggccac cgtcggagtc tcgcccgacc     2580

accagggcaa gggtctgggc agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg     2640

ccggggtgcc cgccttcctg gaaacctccg cgccccgcaa cctccccttc tacgagcggc     2700

tcggcttcac cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga     2760

cccgcaagcc cggtgcctga ggtacacgga attcttctct gcctggtctt caggtcccaa     2820

tcctccgctt ccgcgcttgc gcgccaagac ggctcggatg ccggcggtct ctgctgaaga     2880

gagaagatgg cgcttgacgg accagagcag gtatggcggg tgcagtggcg gcccggcagg     2940

ttacggggct gggtgcggag cgagcgtgat ctgagtggag agcgggccgg ggcaggagcg     3000

tcgggtgggt cggaggtgcc tggaccagtc catgctggac gctgcctgcg accggatctg     3060

ctgtgtcagc gccgccctcg gtgagtcagg gcaaggctgg gagaggaaga cgcggtagaa     3120

gcggagtgag tgagggaagc gatgggcgcg ggaatggccg gcccacgggt cgcaggagac     3180

gggacgccag tcctttggct ccgttccgct ggctccttcg tcagtactga cacctcgggc     3240

ttgtagagca cttcacgcag tgcaaagcgc cccccgtcta tatcatatcg cctctcggtc     3300

ctcctaaaag tcgtatgagg taggcggcgt tcccattctt ttattttagt cctgggaaaa     3360

tggagggttc caagggaggg agggattaga acc                                  3393


<210>  30
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR-KRAB

<400>  30

Met Ala Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Pro 
        195                 200                 205             


Lys Lys Lys Arg Lys Val Asp Gly Gly Gly Ala Leu Ser Pro Gln His 
    210                 215                 220                 


Ser Ala Val Thr Gln Gly Ser Ile Ile Lys Asn Lys Glu Gly Met Asp 
225                 230                 235                 240 


Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys Asp 
                245                 250                 255     


Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr Ala 
            260                 265                 270         


Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn Leu 
        275                 280                 285             


Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg Leu 
    290                 295                 300                 


Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg Glu Ile His Gln Glu 
305                 310                 315                 320 


Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser Val 
                325                 330                 335 


<210>  31
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
acacgacgct cttccgatct acataacggt gtggaaagga cgaaacaccg                  50


<210>  32
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
acacgacgct cttccgatct tagttacggt gtggaaagga cgaaacaccg                  50


<210>  33
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  34
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
caagcagaag acggcatacg agatggtcta accagagaga gccag                       45


<210>  35
<211>  2579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MED20 homology donor

<400>  35
gtggtggcgg gcgcctgtag tcccagctac tcgggactac aggagaatcg cttgaaccca       60

agaggcggag tgttgcagtg agccaagatc gctccactgc actccagtct ggcgacagag      120

cgagaccccg tcttaaaaaa aacaaaacaa aacaaaaaaa aaacctttgc tttcccgcct      180

tccaagagga aggggcgcat ctctgaggaa acaagcccgg ggaacccgca gcccggacgg      240

catcctctca tctacacaac ccgaggacat ctccctcagc tcccagagga cggcggacca      300

tggtcaaggt cctctttccg gcctttcaca actccaagcc ccgccccaca aaaccccctg      360

cagtcctacc aagtcactcc catggcgtcg ggccaggaag gtggcagaat cacacagtag      420

aaacgcaggg ttccctgtcc gcccacagaa actccttcag ttccccaaca caaccttctg      480

tctcagaagg gactccggaa atacgtaaaa acagagcgcc gggtccacgc cttccccaag      540

gaatggggcg cgtctcgctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct      600

ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa      660

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa      720

ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt      780

ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct      840

ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc      900

tgcgatcgcg ccaccatggt gagcgagctg attaaggaga acatgcacat gaagctgtac      960

atggagggca ccgtgaacaa ccaccacttc aagtgcacat ccgagggcga aggcaagccc     1020

tacgagggca cccagaccat gagaatcaag gcggtcgagg gcggccctct ccccttcgcc     1080

ttcgacatcc tggctaccag cttcatgtac ggcagcaaaa ccttcatcaa ccacacccag     1140

ggcatccccg acttctttaa gcagtccttc cccgagggct tcacatggga gagagtcacc     1200

acatacgaag acgggggcgt gctgaccgct acccaggaca ccagcctcca ggacggctgc     1260

ctcatctaca acgtcaagat cagaggggtg aacttcccat ccaacggccc tgtgatgcag     1320

aagaaaacac tcggctggga ggcctccacc gagaccctgt accccgctga cggcggcctg     1380

gaaggcagag ccgacatggc cctgaagctc gtgggcgggg gccacctgat ctgcaacttg     1440

aagaccacat acagatccaa gaaacccgct aagaacctca agatgcccgg cgtctactat     1500

gtggacagaa gactggaaag aatcaaggag gccgacaaag agacctacgt cgagcagcac     1560

gaggtggctg tggccagata ctgcgacctc cctagcaaac tggggcacag atgaaccggt     1620

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     1680

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     1740

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     1800

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgcccctc gatgacgcct     1860

ccactgacat catctgcgga ttcccgcccc gaggtttcta aatccagaca ttcccgtttg     1920

gctgagcact ctaggcctac atccatgaag ctaggagagc gacactcaaa gactgcacta     1980

ttgagagaag ctaacgttaa aggcagtgaa tatattcggg agtacagctc cggaacgcgt     2040

gagctctttt agtgggaggg gcggcgctga tggcgcttct ggcctccgaa tgctaggggg     2100

cgctgtgatc gccgggcggc ctcttgggcg ctgggagtcc accgcgcaag cgcatcctgg     2160

cctttcttca gtccccacgt gcgatccttc ccggcaactt tttcgagaaa aatgcccaaa     2220

ttcaaggcgg cccgtggggt ggggggtcag gaaaaacatg cgcccctggc cgatcagatc     2280

ctggctggga atgcggtgcg ggcgggggtc cgggagaagc ggcggggtcg cgggacagga     2340

gaagcggagg aagagtatgt ggggccccgg ctgagccgac ggattttgca gcaagcacgg     2400

cagcaacagg aggaactcga ggccgagcat gggactgggg acaagcccgc ggcgccgcgg     2460

gaacgcacca cgcggctggg tgagtgtctg ggatgaggtc cgaggaagac agtggccagt     2520

agtggggcgg ggtgggcagc taaaaagtgt ctggcagggg aattgcttcg agtcaacaa      2579


<210>  36
<211>  2566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FTSJ3 homology donor

<400>  36
tccggcctcg caaccgacca ccccttctgc aggagaggta cataatggtc gcaaagagca       60

ggcgaaccgg gcagagatcg ctcgctcgct cgcagactga gcgaatccgg actcacccgt      120

ctccttcgcc aagtgataaa acttgtctcg tcggctcttg ccaactttgc ccttcttgcc      180

catggtggaa agggggagta tccctcaatc tggggagaaa gtagaagttg ggaacgtctc      240

tttccggagc accagattcc acttccagtt tcccacttcc agtttcccac ttcccgcagc      300

aattccaccc cgcgcccctc tccgcacact acctagaccc agagccgctt tctccacact      360

tggaaccgca caagtatgca gctaactact tccgcttccg cttgcgtccc ctgcgtccct      420

ggctcgaggt tttccgccat tttgagtgtg gccctagatt gttctcaata ctctgtcctt      480

gggttttgta agttgaaagt tgagactagg aaggcatatc acaagaacta taaacagagt      540

ttcaatgagg caacactgag gaggagttct actccttcct catccccttc caaagcacct      600

gaactctctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg      660

cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg      720

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc      780

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca      840

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct ctgagctatt      900

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tgcgatcgcg      960

ccaccatggt gagcgagctg attaaggaga acatgcacat gaagctgtac atggagggca     1020

ccgtgaacaa ccaccacttc aagtgcacat ccgagggcga aggcaagccc tacgagggca     1080

cccagaccat gagaatcaag gcggtcgagg gcggccctct ccccttcgcc ttcgacatcc     1140

tggctaccag cttcatgtac ggcagcaaaa ccttcatcaa ccacacccag ggcatccccg     1200

acttctttaa gcagtccttc cccgagggct tcacatggga gagagtcacc acatacgaag     1260

acgggggcgt gctgaccgct acccaggaca ccagcctcca ggacggctgc ctcatctaca     1320

acgtcaagat cagaggggtg aacttcccat ccaacggccc tgtgatgcag aagaaaacac     1380

tcggctggga ggcctccacc gagaccctgt accccgctga cggcggcctg gaaggcagag     1440

ccgacatggc cctgaagctc gtgggcgggg gccacctgat ctgcaacttg aagaccacat     1500

acagatccaa gaaacccgct aagaacctca agatgcccgg cgtctactat gtggacagaa     1560

gactggaaag aatcaaggag gccgacaaag agacctacgt cgagcagcac gaggtggctg     1620

tggccagata ctgcgacctc cctagcaaac tggggcacag atgaaccggt ctgtgccttc     1680

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     1740

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     1800

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     1860

tagcaggcat gctggggatg cggtgggctc tatggagaag ccgcccctcc catcatggtt     1920

cccttagtgt ggtctcgccg cacaacccgc ccatgtacac ggaattcttc tctgcctggt     1980

cttcaggtcc caatcctccg cttccgcgct tgcgcgccaa gacggctcgg atgccggcgg     2040

tctctgctga agagagaaga tggcgcttga cggaccagag caggtatggc gggtgcagtg     2100

gcggcccggc aggttacggg gctgggtgcg gagcgagcgt gatctgagtg gagagcgggc     2160

cggggcagga gcgtcgggtg ggtcggaggt gcctggacca gtccatgctg gacgctgcct     2220

gcgaccggat ctgctgtgtc agcgccgccc tcggtgagtc agggcaaggc tgggagagga     2280

agacgcggta gaagcggagt gagtgaggga agcgatgggc gcgggaatgg ccggcccacg     2340

ggtcgcagga gacgggacgc cagtcctttg gctccgttcc gctggctcct tcgtcagtac     2400

tgacacctcg ggcttgtaga gcacttcacg cagtgcaaag cgccccccgt ctatatcata     2460

tcgcctctcg gtcctcctaa aagtcgtatg aggtaggcgg cgttcccatt cttttatttt     2520

agtcctggga aaatggaggg ttccaaggga gggagggatt agaacc                    2566


<210>  37
<211>  11363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 expression vector

<400>  37
ttcatgcagc tgatccacga cgacagcctg acctttaaag aggacatcca gaaagcccag       60

gtgtccggcc agggcgatag cctgcacgag cacattgcca atctggccgg cagccccgcc      120

attaagaagg gcatcctgca gacagtgaag gtggtggacg agctcgtgaa agtgatgggc      180

cggcacaagc ccgagaacat cgtgatcgaa atggccagag agaaccagac cacccagaag      240

ggacagaaga acagccgcga gagaatgaag cggatcgaag agggcatcaa agagctgggc      300

agccagatcc tgaaagaaca ccccgtggaa aacacccagc tgcagaacga gaagctgtac      360

ctgtactacc tgcagaatgg gcgggatatg tacgtggacc aggaactgga catcaaccgg      420

ctgtccgact acgatgtgga ccatatcgtg cctcagagct ttctgaagga cgactccatc      480

gacaacaagg tgctgaccag aagcgacaag aaccggggca agagcgacaa cgtgccctcc      540

gaagaggtcg tgaagaagat gaagaactac tggcggcagc tgctgaacgc caagctgatt      600

acccagagaa agttcgacaa tctgaccaag gccgagagag gcggcctgag cgaactggat      660

aaggccggct tcatcaagag acagctggtg gaaacccggc agatcacaaa gcacgtggca      720

cagatcctgg actcccggat gaacactaag tacgacgaga atgacaagct gatccgggaa      780

gtgaaagtga tcaccctgaa gtccaagctg gtgtccgatt tccggaagga tttccagttt      840

tacaaagtgc gcgagatcaa caactaccac cacgcccacg acgcctacct gaacgccgtc      900

gtgggaaccg ccctgatcaa aaagtaccct aagctggaaa gcgagttcgt gtacggcgac      960

tacaaggtgt acgacgtgcg gaagatgatc gccaagagcg agcaggaaat cggcaaggct     1020

accgccaagt acttcttcta cagcaacatc atgaactttt tcaagaccga gattaccctg     1080

gccaacggcg agatccggaa gcggcctctg atcgagacaa acggcgaaac cggggagatc     1140

gtgtgggata agggccggga ttttgccacc gtgcggaaag tgctgagcat gccccaagtg     1200

aatatcgtga aaaagaccga ggtgcagaca ggcggcttca gcaaagagtc tatcctgccc     1260

aagaggaaca gcgataagct gatcgccaga aagaaggact gggaccctaa gaagtacggc     1320

ggcttcgaca gccccaccgt ggcctattct gtgctggtgg tggccaaagt ggaaaagggc     1380

aagtccaaga aactgaagag tgtgaaagag ctgctgggga tcaccatcat ggaaagaagc     1440

agcttcgaga agaatcccat cgactttctg gaagccaagg gctacaaaga agtgaaaaag     1500

gacctgatca tcaagctgcc taagtactcc ctgttcgagc tggaaaacgg ccggaagaga     1560

atgctggcct ctgccggcga actgcagaag ggaaacgaac tggccctgcc ctccaaatat     1620

gtgaacttcc tgtacctggc cagccactat gagaagctga agggctcccc cgaggataat     1680

gagcagaaac agctgtttgt ggaacagcac aagcactacc tggacgagat catcgagcag     1740

atcagcgagt tctccaagag agtgatcctg gccgacgcta atctggacaa agtgctgtcc     1800

gcctacaaca agcaccggga taagcccatc agagagcagg ccgagaatat catccacctg     1860

tttaccctga ccaatctggg agcccctgcc gccttcaagt actttgacac caccatcgac     1920

cggaagaggt acaccagcac caaagaggtg ctggacgcca ccctgatcca ccagagcatc     1980

accggcctgt acgagacacg gatcgacctg tctcagctgg gaggcgacaa aaggccggcg     2040

gccacgaaaa aggccggcca ggcaaaaaag aaaaagggat ccggagcgac taatttttcc     2100

ctgctgaagc aggccggcga tgtagaagaa aacccgggcc ctatggtgag caagggcgag     2160

gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac     2220

aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag     2280

ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc     2340

tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag     2400

tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac     2460

tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg     2520

aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac     2580

aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc     2640

aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac     2700

acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc     2760

gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc     2820

gccgccggga tcactctcgg catggacgag ctgtacaagt aaaattcacg cgttaagtcg     2880

acgtcgactt taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa     2940

gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct gctttttgct     3000

tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg     3060

aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt     3120

ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc     3180

tctagcagta cgtatagtag ttcatgtcat cttattattc agtatttata acttgcaaag     3240

aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg ttacaaataa     3300

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     3360

ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg cccctaactc     3420

cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa     3480

ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt     3540

gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg agtcgtatta     3600

cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     3660

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     3720

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag     3780

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     3840

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     3900

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     3960

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     4020

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     4080

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     4140

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     4200

caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct     4260

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     4320

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     4380

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     4440

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     4500

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     4560

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     4620

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     4680

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     4740

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     4800

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     4860

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc     4920

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     4980

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     5040

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     5100

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     5160

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     5220

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     5280

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     5340

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     5400

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     5460

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     5520

ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     5580

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     5640

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     5700

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     5760

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     5820

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     5880

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     5940

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     6000

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     6060

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     6120

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     6180

cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg     6240

ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta     6300

cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca     6360

ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta aagggaacaa     6420

aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct tgcaacatgg     6480

taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca tgccgattgg     6540

tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt ctgacatgga     6600

ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc ctagctcgat     6660

acataaacgg gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag     6720

ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc     6780

gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa     6840

tctctagcag tggcgcccga acagggactt gaaagcgaaa gggaaaccag aggagctctc     6900

tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt     6960

gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt gcgagagcgt     7020

cagtattaag cgggggagaa ttagatcgcg atgggaaaaa attcggttaa ggccaggggg     7080

aaagaaaaaa tataaattaa aacatatagt atgggcaagc agggagctag aacgattcgc     7140

agttaatcct ggcctgttag aaacatcaga aggctgtaga caaatactgg gacagctaca     7200

accatccctt cagacaggat cagaagaact tagatcatta tataatacag tagcaaccct     7260

ctattgtgtg catcaaagga tagagataaa agacaccaag gaagctttag acaagataga     7320

ggaagagcaa aacaaaagta agaccaccgc acagcaagcg gccgctgatc ttcagacctg     7380

gaggaggaga tatgagggac aattggagaa gtgaattata taaatataaa gtagtaaaaa     7440

ttgaaccatt aggagtagca cccaccaagg caaagagaag agtggtgcag agagaaaaaa     7500

gagcagtggg aataggagct ttgttccttg ggttcttggg agcagcagga agcactatgg     7560

gcgcagcgtc aatgacgctg acggtacagg ccagacaatt attgtctggt atagtgcagc     7620

agcagaacaa tttgctgagg gctattgagg cgcaacagca tctgttgcaa ctcacagtct     7680

ggggcatcaa gcagctccag gcaagaatcc tggctgtgga aagataccta aaggatcaac     7740

agctcctggg gatttggggt tgctctggaa aactcatttg caccactgct gtgccttgga     7800

atgctagttg gagtaataaa tctctggaac agatttggaa tcacacgacc tggatggagt     7860

gggacagaga aattaacaat tacacaagct taatacactc cttaattgaa gaatcgcaaa     7920

accagcaaga aaagaatgaa caagaattat tggaattaga taaatgggca agtttgtgga     7980

attggtttaa cataacaaat tggctgtggt atataaaatt attcataatg atagtaggag     8040

gcttggtagg tttaagaata gtttttgctg tactttctat agtgaataga gttaggcagg     8100

gatattcacc attatcgttt cagacccacc tcccaacccc gaggggaccc gattccgggg     8160

cggggcgaat cttttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata     8220

gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt     8280

caaaattttg attccggggc ggggcgaatc gattccgggg cggggcgaat cctcgagttt     8340

cccatgattc cttcatattt gcatatacga tacaaggctg ttagagagat aattagaatt     8400

aatttgactg taaacacaaa gatattagta caaaatacgt gacgtagaaa gtaataattt     8460

cttgggtagt ttgcagtttt aaaattatgt tttaaaatgg actatcatat gcttaccgta     8520

acttgaaagt atttcgattt cttggcttta tatatcttgt ggaaaggacg aaacaccgtc     8580

cctagtggcc ccactgtggt ttcagagcta tgctggaaac agcatagcaa gttgaaataa     8640

ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt taattaaggg     8700

ggcccgggtt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc ggctgctctg     8760

ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc ttcacgtccg     8820

ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg acgcttcctg     8880

ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg tgacaaacgg     8940

aagccgcacc tctcactagt accctcgcag acggacagcg ccagggagca atggcagcgc     9000

gccgaccgcg atgggctgtg gccaatagcg gctgctcagc agggcgcgcc gagagcagcg     9060

gccgggaagg ggcggtgcgg gaggcggggt gtggggcggt agtgtgggcc ctgttcctgc     9120

ccgcgcggtg ttccgcattc tgcaagcctc cggagcgcac gtcggcagtc ggctccctcg     9180

ttgaccgaat caccgacctc tctccccagg ggagcgctta cgtagaagga gaggccacca     9240

tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc gacaagaagt     9300

acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc accgacgagt     9360

acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac agcatcaaga     9420

agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc acccggctga     9480

agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat ctgcaagaga     9540

tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg gaagagtcct     9600

tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac atcgtggacg     9660

aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa ctggtggaca     9720

gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg atcaagttcc     9780

ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg gacaagctgt     9840

tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc aacgccagcg     9900

gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg ctggaaaatc     9960

tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg attgccctga    10020

gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat gccaaactgc    10080

agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag atcggcgacc    10140

agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg ctgagcgaca    10200

tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg atcaagagat    10260

acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag cagctgcctg    10320

agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc tacattgacg    10380

gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa aagatggacg    10440

gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag cagcggacct    10500

tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc attctgcggc    10560

ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag aagatcctga    10620

ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga ttcgcctgga    10680

tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg gtggacaagg    10740

gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac ctgcccaacg    10800

agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat aacgagctga    10860

ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc ggcgagcaga    10920

aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg aagcagctga    10980

aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc ggcgtggaag    11040

atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc aaggacaagg    11100

acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg accctgacac    11160

tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac ctgttcgacg    11220

acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg ctgagccgga    11280

agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat ttcctgaagt    11340

ccgacggctt cgccaacaga aac                                            11363


<210>  38
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 homology donor

<400>  38
tgctttctct gaccagcatt ctctcccctg ggcctgtgcc gctttctgtc tgtagcttgt       60

ggcctgggtc acctctacgg ctggcccaga tccttccctg ccgcctcctt caggttccgt      120

cttcctccac tccctcttcc ccttgctctc tgctgtgttg ctgcccaagg atgctctttc      180

cggagcactt ccttctcggc gctgcaccac gtgatgtcct ctgagcggat cctccccgtg      240

tctgggtcct ctccgggcat ctctcctccc tcacccaacc ccatgccgtc ttcactcgct      300

gggttccctt ttccttctcc ttctggggcc tgtgccatct ctcgtttctt aggatggcct      360

tctccgacgg atgtctccct tgcgtcccgc ctccccttct tgtaggcctg catcatcacc      420

gtttttctgg acaaccccaa agtaccccgt ctccctggct ttagccacct ctccatcctc      480

ttgctttctt tgcctggaca ccccgttctc ctgtggattc gggtcacctc tcactccttt      540

catttgggca gctcccctac cccccttacc tctctagtct gtgctagctc ttccagcccc      600

ctgtcatggc atcttccagg ggtccgagag ctcagctagt cttcttcctc caacccgggc      660

ccctatgtcc acttcaggac agcatgtttg ctgcctccag ggatcctgtg tccccgagct      720

gggaccacct tatattccca gggccggtta atgtggctct ggttctgggt acttttatct      780

gtcccctcca ccccacagtg gggcaagctg tggaatgtgt gtcagttagg gtgtggaaag      840

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc      900

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat      960

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     1020

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     1080

gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     1140

tgcaaaaagc tgcgatcgcg ccaccatggt gagcgagctg attaaggaga acatgcacat     1200

gaagctgtac atggagggca ccgtgaacaa ccaccacttc aagtgcacat ccgagggcga     1260

aggcaagccc tacgagggca cccagaccat gagaatcaag gcggtcgagg gcggccctct     1320

ccccttcgcc ttcgacatcc tggctaccag cttcatgtac ggcagcaaaa ccttcatcaa     1380

ccacacccag ggcatccccg acttctttaa gcagtccttc cccgagggct tcacatggga     1440

gagagtcacc acatacgaag acgggggcgt gctgaccgct acccaggaca ccagcctcca     1500

ggacggctgc ctcatctaca acgtcaagat cagaggggtg aacttcccat ccaacggccc     1560

tgtgatgcag aagaaaacac tcggctggga ggcctccacc gagaccctgt accccgctga     1620

cggcggcctg gaaggcagag ccgacatggc cctgaagctc gtgggcgggg gccacctgat     1680

ctgcaacttg aagaccacat acagatccaa gaaacccgct aagaacctca agatgcccgg     1740

cgtctactat gtggacagaa gactggaaag aatcaaggag gccgacaaag agacctacgt     1800

cgagcagcac gaggtggctg tggccagata ctgcgacctc cctagcaaac tggggcacag     1860

atgaaccggt ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct     1920

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     1980

tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     2040

ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggactt     2100

actagggaca ggattggtga cagaaaagcc ccatccttag gcctcctcct tcctagtctc     2160

ctgatattgg gtctaacccc cacctcctgt taggcagatt ccttatctgg tgacacaccc     2220

ccatttcctg gagccatctc tctccttgcc agaacctcta aggtttgctt acgatggagc     2280

cagagaggat cctgggaggg agagcttggc agggggtggg agggaagggg gggatgcgtg     2340

acctgcccgg ttctcagtgg ccaccctgcg ctaccctctc ccagaacctg agctgctctg     2400

acgcggctgt ctggtgcgtt tcactgatcc tggtgctgca gcttccttac acttcccaag     2460

aggagaagca gtttggaaaa acaaaatcag aataagttgg tcctgagttc taactttggc     2520

tcttcacctt tctagtcccc aatttatatt gttcctccgt gcgtcagttt tacctgtgag     2580

ataaggccag tagccagccc cgtcctggca gggctgtggt gaggaggggg gtgtccgtgt     2640

ggaaaactcc ctttgtgaga atggtgcgtc ctaggtgttc accaggtcgt ggccgcctct     2700

actccctttc tctttctcca tccttctttc cttaaagagt ccccagtgct atctgggaca     2760

tattcctccg cccagagcag ggtcccgctt ccctaaggcc ctgctctggg cttctgggtt     2820

tgagtccttg gcaagcccag gagaggcgct caggcttccc tgtccccctt cctcgtccac     2880

catctcatgc ccctggctct cctgcccctt ccctacaggg gttcctggct ctgctct        2937


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MED20 sgRNA

<400>  39
gggcgtgtct cggcacccct                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FTSJ3 sgRNA

<400>  40
gaattccggg tcaatgggcg                                                   20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 sgRNA

<400>  41
gtccctagtg gccccactgt g                                                 21


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
gtctggtcta tctgcctggc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
aaacagacac aagcgggtct                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
tcctgctgca atcggagaag                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
gttacgaacc atccccctgg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
acccttccta gctccctctg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  47
ggtagccagg atgtcgaagg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
ccggcgtcta ctatgtggac                                                   20


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  49
ggtctaacca gagagagcca g                                                 21


