                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  ANTI-AXL ANTIBODY AND USES THEREOF

<130>  9869SG6014

<150>  SG10202000919U
<151>  2020-01-31

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G6 heavy chain DNA sequence

<400>  1
gaggtaaagc tggaggagtc tggacctggc ctggtggcgc cctcacagaa cctgtccatt       60

atttgcactg tctctgggtt ttcattaagc acatatgata tcagttggat tcgtcagtcc      120

ccaggaaagg gtctggaatg gcttggagaa atatggactg gtggaggcac aaattataat      180

gcggctttca tgtccagact gagcatcacc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctggaaat tgaggacaca gccatatatt attgtgtaag agatcagaga      300

catcgggggt ctgctaactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  2
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 light chain DNA sequence

<400>  2
gatattgtga tcacccagac tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttattgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaagactga agacctggca gtttattact gtcaccaata ttatatctat      300

ccgtacacgt tcggaggggg gatcaagctg gaaataaaa                             339


<210>  3
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8H4 heavy chain DNA sequence

<400>  3
gaagtcaagc tgcaggagtc agggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtaatta cacatactat      180

acagacagtg tgaaggggcg attcaccatt tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatcct      300

tactacggta gtagggactg gttcttcgat gtctggggcg cagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  4
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8H4 light chain DNA sequence

<400>  4
gacattgtga tgacacagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccggctc aagtgtgagt tacatgtcct ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cattcacgtt cggctcgggg      300

acaaagctgg agatcaaa                                                    318


<210>  5
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F10 heavy chain DNA sequence

<400>  5
gaagtgcagc tggaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc agctatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaagcac aaattataat      180

tcggctctca tgtccagact gagcatcacc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa ggactatgat      300

tacgagagag ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  6
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F10 light chain DNA sequence

<400>  6
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacataagt cagaacaatg gcaattattt aaactggtat      120

cagcagaaac cagatggaac tgttaaactc ctgatctact acacatcaag attacactca      180

ggagtcccat caaggttcag tggcagtggg tctggaacag attattctct caccattagc      240

aacctggagc aagaagatct tgccacttac ttttgccaac agggtcatat gtttccgtgg      300

acgttccgtg gaggcaccaa gctggagatc aaa                                   333


<210>  7
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4H8 heavy chain DNA sequence

<400>  7
gaagtgaagc tgcaggagtc aggacctggc ctggtggcgc cctcacagaa cctgtccatt       60

atttgcactg tctctgggtt ttcattaagc acatatgata tcagttggat tcgtcagtcc      120

ccaggaaagg gtctggaatg gcttggagaa atatggactg gtggaggcac aaattataat      180

gcggctttca tgtccagact gagcatcacc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctggaaat tgaggacaca gccatatatt attgtgtaag agatcagaga      300

cattgggggt ctgctaactg gggccaaggg actctggtca ccgtctcctc a               351


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 heavy chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (26)..(33)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (96)..(106)
<223>  CDR3

<400>  8

Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Asn Leu Ser Ile Ile Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Glu Ile Glu Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Gln Arg His Arg Gly Ser Ala Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 light chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (27)..(38)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (56)..(58)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (95)..(103)
<223>  CDR3

<400>  9

Asp Ile Val Ile Thr Gln Thr Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Thr Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Ile Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 heavy chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (26)..(33)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (51)..(58)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (97)..(111)
<223>  CDR3

<400>  10

Glu Val Lys Leu Gln Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Tyr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Pro Tyr Tyr Gly Ser Arg Asp Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 light chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (27)..(31)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (48)..(51)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (88)..(96)
<223>  CDR3

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Gly Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 heavy chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (26)..(33)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (96)..(107)
<223>  CDR3

<400>  12

Glu Val Gln Leu Glu Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asp Tyr Asp Tyr Glu Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  13
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 light chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (31)..(36)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (54)..(56)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (93)..(103)
<223>  CDR3

<400>  13

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Gln Asn 
            20                  25                  30          


Asn Gly Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
        35                  40                  45              


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Asn Leu Glu Gln Glu Asp Leu Ala Thr Tyr Phe Cys Gln Gln Gly His 
                85                  90                  95      


Met Phe Pro Trp Thr Phe Arg Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H8 heavy chain amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (26)..(33)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (96)..(106)
<223>  CDR3

<400>  14

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Asn Leu Ser Ile Ile Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Glu Ile Glu Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Gln Arg His Trp Gly Ser Ala Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 heavy chain CDR1

<400>  15

Gly Phe Ser Leu Ser Thr Tyr Asp 
1               5               


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 heavy chain CDR2

<400>  16

Ile Trp Thr Gly Gly Gly Thr 
1               5           


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 heavy chain CDR3

<400>  17

Val Arg Asp Gln Arg His Arg Gly Ser Ala Asn 
1               5                   10      


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 light chain CDR1

<400>  18

Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 light chain CDR2

<400>  19

Trp Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 and 4H8 light chain CDR3

<400>  20

His Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H8 heavy chain CDR3

<400>  21

Val Arg Asp Gln Arg His Trp Gly Ser Ala Asn 
1               5                   10      


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 heavy chain CDR1

<400>  22

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 heavy chain CDR2

<400>  23

Ile Ser Ser Gly Gly Asn Tyr Thr 
1               5               


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 heavy chain CDR3

<400>  24

Ala Arg His Pro Tyr Tyr Gly Ser Arg Asp Trp Phe Phe Asp Val 
1               5                   10                  15  


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 light chain CDR1

<400>  25

Ser Ser Val Ser Tyr 
1               5   


<210>  26
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 light chain CDR2

<400>  26

Asp Thr Ser 
1           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 light chain CDR3

<400>  27

Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 heavy chain CDR1

<400>  28

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 heavy chain CDR2

<400>  29

Ile Trp Ala Gly Gly Ser Thr 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 heavy chain CDR3

<400>  30

Ala Lys Asp Tyr Asp Tyr Glu Arg Ala Met Asp Tyr 
1               5                   10          


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 light chain CDR1

<400>  31

Gln Asn Asn Gly Asn Tyr 
1               5       


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 light chain CDR2

<400>  32

Tyr Thr Ser 
1           


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 light chain CDR3

<400>  33

Gln Gln Gly His Met Phe Pro Trp Thr Phe Arg 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is any amino acid

<400>  34

Val Arg Asp Gln Arg His Xaa Gly Ser Ala Asn 
1               5                   10      


<210>  35
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human AXL

<400>  35

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  36
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human AXL isoform 1

<400>  36

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  37
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of extracellular domain of human AXL

<400>  37

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp 
    450     


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved motif unique to TAM family members

<400>  38

Lys Trp Ile Ala Ile Glu Ser 
1               5           


