                         SEQUENCE LISTING

<110>  INSERM
 
<120>  C-X-C MOTIF CHEMOKINE RECEPTOR 4 ANTAGONIST

<130>  MAMMANO 19366 / MC

<160>  32    

<170>  PatentIn version 3.3

<210>  1
<211>  100
<212>  PRT
<213>  Dengue virus type 2

<400>  1

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg 
            100 


<210>  2
<211>  114
<212>  PRT
<213>  Dengue virus type 1

<400>  2

Met Asn Asn Gln Arg Lys Lys Thr Gly Arg Pro Ser Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Ala Arg Asn Arg Val Ser Thr Val Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Lys Gly Leu Leu Ser Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Ala Arg Trp Gly Ser Phe Lys Lys Asn Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Arg Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Asn Ile Met Asn 
                85                  90                  95      


Arg Arg Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala 
            100                 105                 110         


Leu Ala 
        


<210>  3
<211>  114
<212>  PRT
<213>  Dengue virus type 3

<400>  3

Met Asn Asn Gln Arg Lys Lys Thr Gly Lys Pro Ser Ile Asn Met Leu 
1               5                   10                  15      


Lys Arg Val Arg Asn Arg Val Ser Thr Gly Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Lys Gly Leu Leu Asn Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Val Leu Ala Arg Trp Gly Thr Phe Lys Lys Ser Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Lys Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Ser Ile Ile Asn 
                85                  90                  95      


Gln Arg Lys Lys Thr Ser Leu Cys Leu Met Met Ile Leu Pro Ala Ala 
            100                 105                 110         


Leu Ala 
        


<210>  4
<211>  113
<212>  PRT
<213>  Dengue virus type 4

<400>  4

Met Asn Gln Arg Lys Lys Val Val Arg Pro Pro Phe Asn Met Leu Lys 
1               5                   10                  15      


Arg Glu Arg Asn Arg Val Ser Thr Pro Gln Gly Leu Val Lys Arg Phe 
            20                  25                  30          


Ser Thr Gly Leu Phe Ser Gly Lys Gly Pro Leu Arg Met Val Leu Ala 
        35                  40                  45              


Phe Ile Thr Phe Leu Arg Val Leu Ser Ile Pro Pro Thr Ala Gly Ile 
    50                  55                  60                  


Leu Lys Arg Trp Gly Gln Leu Lys Lys Asn Lys Ala Ile Lys Ile Leu 
65                  70                  75                  80  


Ile Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Gly 
                85                  90                  95      


Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met 
            100                 105                 110         


Ala 
    


<210>  5
<211>  35
<212>  PRT
<213>  Dengue virus type 2

<400>  5

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg 
            20                  25                  30          


Arg Arg Arg 
        35  


<210>  6
<211>  35
<212>  PRT
<213>  Dengue virus type 1

<400>  6

Leu Ala Arg Trp Gly Ser Phe Lys Lys Asn Gly Ala Ile Lys Val Leu 
1               5                   10                  15      


Arg Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Asn Ile Met Asn Arg 
            20                  25                  30          


Arg Lys Arg 
        35  


<210>  7
<211>  35
<212>  PRT
<213>  Dengue virus type 3

<400>  7

Leu Ala Arg Trp Gly Thr Phe Lys Lys Ser Gly Ala Ile Lys Val Leu 
1               5                   10                  15      


Lys Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Ser Ile Ile Asn Gln 
            20                  25                  30          


Arg Lys Lys 
        35  


<210>  8
<211>  35
<212>  PRT
<213>  Dengue virus type 4

<400>  8

Leu Lys Arg Trp Gly Gln Leu Lys Lys Asn Lys Ala Ile Lys Ile Leu 
1               5                   10                  15      


Ile Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Gly 
            20                  25                  30          


Arg Lys Arg 
        35  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  peptidomimetics of the pepRF1 peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  X1 is K or A

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X2 is T, S or Q

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X3 is I, F or L

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  X4 is S or N

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  X5 is K or G

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  X6 is N or K

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  X7 is V or I

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  X8 is R, K or I

<400>  9

Leu Xaa Arg Trp Gly Xaa Xaa Lys Lys Xaa Xaa Ala Ile Xaa Xaa Leu 
1               5                   10                  15      


Xaa 
    


<210>  10
<211>  17
<212>  PRT
<213>  Dengue virus type 2

<400>  10

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg 
    


<210>  11
<211>  17
<212>  PRT
<213>  Dengue virus type 1

<400>  11

Leu Lys Arg Trp Gly Ser Phe Lys Lys Asn Gly Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg 
    


<210>  12
<211>  17
<212>  PRT
<213>  Dengue virus type 1

<400>  12

Leu Ala Arg Trp Gly Ser Phe Lys Lys Asn Gly Ala Ile Lys Val Leu 
1               5                   10                  15      


Arg 
    


<210>  13
<211>  17
<212>  PRT
<213>  Dengue virus type 3

<400>  13

Leu Ala Arg Trp Gly Thr Phe Lys Lys Ser Gly Ala Ile Lys Val Leu 
1               5                   10                  15      


Lys 
    


<210>  14
<211>  17
<212>  PRT
<213>  Dengue virus type 4

<400>  14

Leu Lys Arg Trp Gly Gln Leu Lys Lys Asn Lys Ala Ile Lys Ile Leu 
1               5                   10                  15      


Ile 
    


<210>  15
<211>  15
<212>  PRT
<213>  Dengue virus

<400>  15

Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg Arg Arg 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Dengue virus

<400>  16

Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg Arg Arg Arg 
1               5                   10                  15  


<210>  17
<211>  16
<212>  PRT
<213>  Dengue virus

<400>  17

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


<210>  18
<211>  25
<212>  PRT
<213>  Dengue virus

<400>  18

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg Gly Phe Arg Lys Glu Ile Gly Arg 
            20                  25  


<210>  19
<211>  26
<212>  PRT
<213>  Dengue virus

<400>  19

Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg 
1               5                   10                  15      


Lys Glu Ile Gly Arg Met Leu Asn Ile Leu 
            20                  25      


<210>  20
<211>  25
<212>  PRT
<213>  Dengue virus

<400>  20

Lys Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg Lys Glu Ile 
1               5                   10                  15      


Gly Arg Met Leu Asn Ile Leu Asn Arg 
            20                  25  


<210>  21
<211>  19
<212>  PRT
<213>  Dengue virus

<400>  21

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg Gly Phe 
            


<210>  22
<211>  20
<212>  PRT
<213>  Dengue virus

<400>  22

Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg 
1               5                   10                  15      


Lys Glu Ile Gly 
            20  


<210>  23
<211>  19
<212>  PRT
<213>  Dengue virus

<400>  23

Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg Lys Glu Ile Gly 
1               5                   10                  15      


Arg Met Leu 
            


<210>  24
<211>  18
<212>  PRT
<213>  Dengue virus

<400>  24

Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  25
<211>  18
<212>  PRT
<213>  Dengue virus

<400>  25

Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  26
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  delta C4-pepR

<400>  26

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
            20                  25                  30      


<210>  27
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  delta C8-pepR

<400>  27

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu 
            20                  25          


<210>  28
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  delta C12 pep-R

<400>  28

Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu 
1               5                   10                  15      


Arg Gly Phe Arg Lys Glu Ile 
            20              


<210>  29
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  delta N4-pepR

<400>  29

Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg 
1               5                   10                  15      


Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg Arg Arg Arg 
            20                  25                  30      


<210>  30
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  delta N8-pepR

<400>  30

Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg Lys Glu Ile Gly 
1               5                   10                  15      


Arg Met Leu Asn Ile Leu Asn Arg Arg Arg Arg 
            20                  25          


<210>  31
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  delta N12-pepR

<400>  31

Ile Asn Val Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn 
1               5                   10                  15      


Ile Leu Asn Arg Arg Arg Arg 
            20              


<210>  32
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  delta N22-pepR

<400>  32

Gly Arg Met Leu Asn Ile Leu Asn Arg Arg Arg Arg 
1               5                   10          


