                         SEQUENCE LISTING

<110>  BiOrion Technologies B.V.
 
<120>  Platelet Derived Growth Factor Receptor (PDGFR) antibodies, 
       conjugates, compositions, and uses thereof.

<130>  P124441PC00

<140>  PCT/NL2021/050074
<141>  2021-02-05

<150>  EP 20156203.0
<151>  2020-02-07

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1B5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is E or T

<400>  1

Xaa Ser Ala Met Ser 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1H4

<400>  2

Pro Phe Ala Met Ala 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1D4

<400>  3

Arg Asp Val Val Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1E12


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A or P

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is M or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is G or S

<400>  4

Xaa Tyr Leu Xaa Xaa 
1               5   


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1B5

<400>  5

Gly Ile Ser Ser Gly Gly Gly Arg Ser Thr Thr 
1               5                   10      


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1H4

<400>  6

Arg Ile Ser Trp Thr Ala Gly Arg Thr Glu 
1               5                   10  


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1D4

<400>  7

Leu Val Thr Arg Ser Tyr Ser Thr Tyr 
1               5                   


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1E12


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is P or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is T or S

<400>  8

Ala Trp Arg Trp Xaa Thr Ser Xaa Thr Tyr 
1               5                   10  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1B5

<400>  9

Thr Gly Tyr Cys Ser Gly Tyr Asn Cys Asn Phe Ala Pro 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1H4

<400>  10

Arg Phe Val Pro Ser Ser Gly Pro Thr Val Phe Asp Thr 
1               5                   10              


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1D4

<400>  11

Asp Gln Gly Phe Cys Ser Gly Ser Gly Cys Tyr Asp Trp Arg Thr Phe 
1               5                   10                  15      


His Val 
        


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1E12


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is G or E

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A or P

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is P or E

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is A or P

<400>  12

Arg Arg Xaa Ile Leu Tyr Gly Pro Xaa Thr Ser Xaa Thr Xaa Tyr Asp 
1               5                   10                  15      


Phe 
    


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1B5

<400>  13

Glu Ser Ala Met Ser 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1H4

<400>  14

Pro Phe Ala Met Ala 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1D4

<400>  15

Arg Asp Val Val Gly 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1E12

<400>  16

Ala Tyr Leu Met Gly 
1               5   


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1B5

<400>  17

Gly Ile Ser Ser Gly Gly Gly Arg Ser Thr Thr 
1               5                   10      


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1H4

<400>  18

Arg Ile Ser Trp Thr Ala Gly Arg Thr Glu 
1               5                   10  


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 1D4

<400>  19

Leu Val Thr Arg Ser Tyr Ser Thr Tyr 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 1E12

<400>  20

Ala Trp Arg Trp Pro Thr Ser Thr Thr Tyr 
1               5                   10  


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1B5

<400>  21

Thr Gly Tyr Cys Ser Gly Tyr Asn Cys Asn Phe Ala Pro 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1H4

<400>  22

Arg Phe Val Pro Ser Ser Gly Pro Thr Val Phe Asp Thr 
1               5                   10              


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1D4

<400>  23

Asp Gln Gly Phe Cys Ser Gly Ser Gly Cys Tyr Asp Trp Arg Thr Phe 
1               5                   10                  15      


His Val 
        


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 1E12

<400>  24

Arg Arg Gly Ile Leu Tyr Gly Pro Ala Thr Ser Pro Thr Ala Tyr Asp 
1               5                   10                  15      


Phe 
    


<210>  25
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B5 HC

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Glu Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Gly Ile Ser Ser Gly Gly Gly Arg Ser Thr Thr Tyr Ala Glu Ser 
    50                  55                  60                  


Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Met Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Thr Gly Tyr Cys Ser Gly Tyr Asn Cys Asn Phe Ala Pro 
            100                 105                 110         


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  26
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B5* HC

<400>  26

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Glu Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Gly Ile Ser Ser Gly Gly Gly Arg Ser Thr Thr Tyr Ala Glu Ser 
    50                  55                  60                  


Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Met Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Thr Gly Tyr Cys Ser Gly Tyr Asn Cys Asn Phe Ala Pro 
            100                 105                 110         


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D4 HC

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Ala Gln Ser Arg Asp 
            20                  25                  30          


Val Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu 
        35                  40                  45              


Ala Leu Val Thr Arg Ser Tyr Ser Thr Tyr Tyr Gly Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Gln Gly Phe Cys Ser Gly Ser Gly Cys Tyr Asp Trp Arg Thr 
            100                 105                 110         


Phe His Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  28
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D4* HC

<400>  28

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Ala Gln Ser Arg Asp 
            20                  25                  30          


Val Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu 
        35                  40                  45              


Ala Leu Val Thr Arg Ser Tyr Ser Thr Tyr Tyr Gly Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Gln Gly Phe Cys Ser Gly Ser Gly Cys Tyr Asp Trp Arg Thr 
            100                 105                 110         


Phe His Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  29
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H4 HC

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ser Ala Ser Trp Arg Thr Gly Asn Pro Phe 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Ala Arg Ile Ser Trp Thr Ala Gly Arg Thr Glu Tyr Ala Glu Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ala Lys Lys Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Arg Phe Val Pro Ser Ser Gly Pro Thr Val Phe Asp Thr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H4* HC

<400>  30

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ser Ala Ser Trp Arg Thr Gly Asn Pro Phe 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Ala Arg Ile Ser Trp Thr Ala Gly Arg Thr Glu Tyr Ala Glu Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ala Lys Lys Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Arg Phe Val Pro Ser Ser Gly Pro Thr Val Phe Asp Thr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E12 HC

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Pro Ser Glu Arg Ser Phe Ser Ala Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Trp Arg Trp Pro Thr Ser Thr Thr Tyr Tyr Ser Asp Ser Gly 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Gly Asp Asn Ala Lys Asn Thr Val Glu 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ile Leu Tyr Gly Pro Ala Thr Ser Pro Thr Ala 
            100                 105                 110         


Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  32
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E12* HC

<400>  32

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Pro Ser Glu Arg Ser Phe Ser Ala Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Trp Arg Trp Pro Thr Ser Thr Thr Tyr Tyr Ser Asp Ser Gly 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Gly Asp Asn Ala Lys Asn Thr Val Glu 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ile Leu Tyr Gly Pro Ala Thr Ser Pro Thr Ala 
            100                 105                 110         


Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  33

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline family

<400>  34

Lys Gly Leu Glu Trp 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  germline family

<400>  35

Lys Glu Arg Glu Leu 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  germline family

<400>  36

Lys Glu Arg Glu Phe 
1               5   


<210>  37
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QPD1B5

<400>  37

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Glu Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Gly Ile Ser Ser Gly Gly Gly Arg Ser Thr Thr Tyr Ala Glu Ser 
    50                  55                  60                  


Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Met Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Thr Gly Tyr Cys Ser Gly Tyr Asn Cys Asn Phe Ala Pro 
            100                 105                 110         


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  38
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QPD1H4

<400>  38

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ser Ala Ser Trp Arg Thr Gly Asn Pro Phe 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Ala Arg Ile Ser Trp Thr Ala Gly Arg Thr Glu Tyr Ala Glu Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ala Lys Lys Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Arg Phe Val Pro Ser Ser Gly Pro Thr Val Phe Asp Thr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QPD1D4

<400>  39

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Ala Gln Ser Arg Asp 
            20                  25                  30          


Val Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu 
        35                  40                  45              


Ala Leu Val Thr Arg Ser Tyr Ser Thr Tyr Tyr Gly Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Gln Gly Phe Cys Ser Gly Ser Gly Cys Tyr Asp Trp Arg Thr 
            100                 105                 110         


Phe His Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  40
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QPD1E12

<400>  40

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Pro Ser Glu Arg Ser Phe Ser Ala Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Trp Arg Trp Pro Thr Ser Thr Thr Tyr Tyr Ser Asp Ser Gly 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Gly Asp Asn Ala Lys Asn Thr Val Glu 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ile Leu Tyr Gly Pro Ala Thr Ser Pro Thr Ala 
            100                 105                 110         


Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


