                         SEQUENCE LISTING

<110>  THE BROAD INSTITUTE, INC.
       PRESIDENT AND FELLOWS OF HARVARD COLLEGE
       MASSACHUSETTS INSTITUTE OF TECHNOLOGY
       THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120>  BASE EDITOR PREDICTIVE ALGORITHM AND METHOD OF USE

<130>  B1195.70092WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/970,684
<151>  2020-02-05

<150>  US 63/038,691
<151>  2020-06-12

<160>  3504  

<170>  PatentIn version 3.5

<210>  1

<400>  1
000

<210>  2

<400>  2
000

<210>  3

<400>  3
000

<210>  4

<400>  4
000

<210>  5
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  6
<211>  4104
<212>  DNA
<213>  Streptococcus pyogenes

<400>  6
atggataaaa aatatagcat tggcctggat attggcacca acagcgtggg ctgggcggtg       60

attaccgatg aatataaagt gccgagcaaa aaatttaaag tgctgggcaa caccgatcgc      120

catagcatta aaaaaaacct gattggcgcg ctgctgtttg atagcggcga aaccgcggaa      180

gcgacccgcc tgaaacgcac cgcgcgccgc cgctataccc gccgcaaaaa ccgcatttgc      240

tatctgcagg aaatttttag caacgaaatg gcgaaagtgg atgatagctt ttttcatcgc      300

ctggaagaaa gctttctggt ggaagaagat aaaaaacatg aacgccatcc gatttttggc      360

aacattgtgg atgaagtggc gtatcatgaa aaatatccga ccatttatca tctgcgcaaa      420

aaactggtgg atagcaccga taaagcggat ctgcgcctga tttatctggc gctggcgcat      480

atgattaaat ttcgcggcca ttttctgatt gaaggcgatc tgaacccgga taacagcgat      540

gtggataaac tgtttattca gctggtgcag acctataacc agctgtttga agaaaacccg      600

attaacgcga gcggcgtgga tgcgaaagcg attctgagcg cgcgcctgag caaaagccgc      660

cgcctggaaa acctgattgc gcagctgccg ggcgaaaaaa aaaacggcct gtttggcaac      720

ctgattgcgc tgagcctggg cctgaccccg aactttaaaa gcaactttga tctggcggaa      780

gatgcgaaac tgcagctgag caaagatacc tatgatgatg atctggataa cctgctggcg      840

cagattggcg atcagtatgc ggatctgttt ctggcggcga aaaacctgag cgatgcgatt      900

ctgctgagcg atattctgcg cgtgaacacc gaaattacca aagcgccgct gagcgcgagc      960

atgattaaac gctatgatga acatcatcag gatctgaccc tgctgaaagc gctggtgcgc     1020

cagcagctgc cggaaaaata taaagaaatt ttttttgatc agagcaaaaa cggctatgcg     1080

ggctatattg atggcggcgc gagccaggaa gaattttata aatttattaa accgattctg     1140

gaaaaaatgg atggcaccga agaactgctg gtgaaactga accgcgaaga tctgctgcgc     1200

aaacagcgca cctttgataa cggcagcatt ccgcatcaga ttcatctggg cgaactgcat     1260

gcgattctgc gccgccagga agatttttat ccgtttctga aagataaccg cgaaaaaatt     1320

gaaaaaattc tgacctttcg cattccgtat tatgtgggcc cgctggcgcg cggcaacagc     1380

cgctttgcgt ggatgacccg caaaagcgaa gaaaccatta ccccgtggaa ctttgaagaa     1440

gtggtggata aaggcgcgag cgcgcagagc tttattgaac gcatgaccaa ctttgataaa     1500

aacctgccga acgaaaaagt gctgccgaaa catagcctgc tgtatgaata ttttaccgtg     1560

tataacgaac tgaccaaagt gaaatatgtg accgaaggca tgcgcaaacc ggcgtttctg     1620

agcggcgaac agaaaaaagc gattgtggat ctgctgttta aaaccaaccg caaagtgacc     1680

gtgaaacagc tgaaagaaga ttattttaaa aaaattgaat gctttgatag cgtggaaatt     1740

agcggcgtgg aagatcgctt taacgcgagc ctgggcacct atcatgatct gctgaaaatt     1800

attaaagata aagattttct ggataacgaa gaaaacgaag atattctgga agatattgtg     1860

ctgaccctga ccctgtttga agatcgcgaa atgattgaag aacgcctgaa aacctatgcg     1920

catctgtttg atgataaagt gatgaaacag ctgaaacgcc gccgctatac cggctggggc     1980

cgcctgagcc gcaaactgat taacggcatt cgcgataaac agagcggcaa aaccattctg     2040

gattttctga aaagcgatgg ctttgcgaac cgcaacttta tgcagctgat tcatgatgat     2100

agcctgacct ttaaagaaga tattcagaaa gcgcaggtga gcggccaggg cgatagcctg     2160

catgaacata ttgcgaacct ggcgggcagc ccggcgatta aaaaaggcat tctgcagacc     2220

gtgaaagtgg tggatgaact ggtgaaagtg atgggccgcc ataaaccgga aaacattgtg     2280

attgaaatgg cgcgcgaaaa ccagaccacc cagaaaggcc agaaaaacag ccgcgaacgc     2340

atgaaacgca ttgaagaagg cattaaagaa ctgggcagcc agattctgaa agaacatccg     2400

gtggaaaaca cccagctgca gaacgaaaaa ctgtatctgt attatctgca gaacggccgc     2460

gatatgtatg tggatcagga actggatatt aaccgcctga gcgattatga tgtggatcat     2520

attgtgccgc agagctttct gaaagatgat agcattgata acaaagtgct gacccgcagc     2580

gataaaaacc gcggcaaaag cgataacgtg ccgagcgaag aagtggtgaa aaaaatgaaa     2640

aactattggc gccagctgct gaacgcgaaa ctgattaccc agcgcaaatt tgataacctg     2700

accaaagcgg aacgcggcgg cctgagcgaa ctggataaag cgggctttat taaacgccag     2760

ctggtggaaa cccgccagat taccaaacat gtggcgcaga ttctggatag ccgcatgaac     2820

accaaatatg atgaaaacga taaactgatt cgcgaagtga aagtgattac cctgaaaagc     2880

aaactggtga gcgattttcg caaagatttt cagttttata aagtgcgcga aattaacaac     2940

tatcatcatg cgcatgatgc gtatctgaac gcggtggtgg gcaccgcgct gattaaaaaa     3000

tatccgaaac tggaaagcga atttgtgtat ggcgattata aagtgtatga tgtgcgcaaa     3060

atgattgcga aaagcgaaca ggaaattggc aaagcgaccg cgaaatattt tttttatagc     3120

aacattatga acttttttaa aaccgaaatt accctggcga acggcgaaat tcgcaaacgc     3180

ccgctgattg aaaccaacgg cgaaaccggc gaaattgtgt gggataaagg ccgcgatttt     3240

gcgaccgtgc gcaaagtgct gagcatgccg caggtgaaca ttgtgaaaaa aaccgaagtg     3300

cagaccggcg gctttagcaa agaaagcatt ctgccgaaac gcaacagcga taaactgatt     3360

gcgcgcaaaa aagattggga tccgaaaaaa tatggcggct ttgatagccc gaccgtggcg     3420

tatagcgtgc tggtggtggc gaaagtggaa aaaggcaaaa gcaaaaaact gaaaagcgtg     3480

aaagaactgc tgggcattac cattatggaa cgcagcagct ttgaaaaaaa cccgattgat     3540

tttctggaag cgaaaggcta taaagaagtg aaaaaagatc tgattattaa actgccgaaa     3600

tatagcctgt ttgaactgga aaacggccgc aaacgcatgc tggcgagcgc gggcgaactg     3660

cagaaaggca acgaactggc gctgccgagc aaatatgtga actttctgta tctggcgagc     3720

cattatgaaa aactgaaagg cagcccggaa gataacgaac agaaacagct gtttgtggaa     3780

cagcataaac attatctgga tgaaattatt gaacagatta gcgaatttag caaacgcgtg     3840

attctggcgg atgcgaacct ggataaagtg ctgagcgcgt ataacaaaca tcgcgataaa     3900

ccgattcgcg aacaggcgga aaacattatt catctgttta ccctgaccaa cctgggcgcg     3960

ccggcggcgt ttaaatattt tgataccacc attgatcgca aacgctatac cagcaccaaa     4020

gaagtgctgg atgcgaccct gattcatcag agcattaccg gcctgtatga aacccgcatt     4080

gatctgagcc agctgggcgg cgat                                            4104


<210>  7
<211>  4104
<212>  DNA
<213>  Streptococcus pyogenes

<400>  7
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg attataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg gcagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggcag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa atctacaatc aattatttga agaaaaccct      600

attaacgcaa gtagagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga gaaatggctt gtttgggaat      720

ctcattgctt tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatagt gaaataacta aggctcccct atcagcttca      960

atgattaagc gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgagggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggcgcct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agataggggg atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga tattcaaaaa gcacaggtgt ctggacaagg ccatagttta     2160

catgaacaga ttgctaactt agctggcagt cctgctatta aaaaaggtat tttacagact     2220

gtaaaaattg ttgatgaact ggtcaaagta atggggcata agccagaaaa tatcgttatt     2280

gaaatggcac gtgaaaatca gacaactcaa aagggccaga aaaattcgcg agagcgtatg     2340

aaacgaatcg aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt     2400

gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctacaaaa tggaagagac     2460

atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt cgatcacatt     2520

gttccacaaa gtttcattaa agacgattca atagacaata aggtactaac gcgttctgat     2580

aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa gatgaaaaac     2640

tattggagac aacttctaaa cgccaagtta atcactcaac gtaagtttga taatttaacg     2700

aaagctgaac gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg     2760

gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact     2820

aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa     2880

ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac     2940

catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat taagaaatat     3000

ccaaaacttg aatcggagtt tgtctatggt gattataaag tttatgatgt tcgtaaaatg     3060

attgctaagt ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat     3120

atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct     3180

ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc     3240

acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag     3300

acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa gcttattgct     3360

cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg atagtccaac ggtagcttat     3420

tcagtcctag tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa     3480

gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt     3540

ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat     3600

agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa     3660

aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt agctagtcat     3720

tatgaaaagt tgaagggtag tccagaagat aacgaacaaa aacaattgtt tgtggagcag     3780

cataagcatt atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt     3840

ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca     3900

atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc     3960

gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa     4020

gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac acgcattgat     4080

ttgagtcagc taggaggtga ctga                                            4104


<210>  8
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes

<400>  8

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  9
<211>  4212
<212>  DNA
<213>  Streptococcus pyogenes

<400>  9
atggataaaa agtattctat tggtttagac atcggcacta attccgttgg atgggctgtc       60

ataaccgatg aatacaaagt accttcaaag aaatttaagg tgttggggaa cacagaccgt      120

cattcgatta aaaagaatct tatcggtgcc ctcctattcg atagtggcga aacggcagag      180

gcgactcgcc tgaaacgaac cgctcggaga aggtatacac gtcgcaagaa ccgaatatgt      240

tacttacaag aaatttttag caatgagatg gccaaagttg acgattcttt ctttcaccgt      300

ttggaagagt ccttccttgt cgaagaggac aagaaacatg aacggcaccc catctttgga      360

aacatagtag atgaggtggc atatcatgaa aagtacccaa cgatttatca cctcagaaaa      420

aagctagttg actcaactga taaagcggac ctgaggttaa tctacttggc tcttgcccat      480

atgataaagt tccgtgggca ctttctcatt gagggtgatc taaatccgga caactcggat      540

gtcgacaaac tgttcatcca gttagtacaa acctataatc agttgtttga agagaaccct      600

ataaatgcaa gtggcgtgga tgcgaaggct attcttagcg cccgcctctc taaatcccga      660

cggctagaaa acctgatcgc acaattaccc ggagagaaga aaaatgggtt gttcggtaac      720

cttatagcgc tctcactagg cctgacacca aattttaagt cgaacttcga cttagctgaa      780

gatgccaaat tgcagcttag taaggacacg tacgatgacg atctcgacaa tctactggca      840

caaattggag atcagtatgc ggacttattt ttggctgcca aaaaccttag cgatgcaatc      900

ctcctatctg acatactgag agttaatact gagattacca aggcgccgtt atccgcttca      960

atgatcaaaa ggtacgatga acatcaccaa gacttgacac ttctcaaggc cctagtccgt     1020

cagcaactgc ctgagaaata taaggaaata ttctttgatc agtcgaaaaa cgggtacgca     1080

ggttatattg acggcggagc gagtcaagag gaattctaca agtttatcaa acccatatta     1140

gagaagatgg atgggacgga agagttgctt gtaaaactca atcgcgaaga tctactgcga     1200

aagcagcgga ctttcgacaa cggtagcatt ccacatcaaa tccacttagg cgaattgcat     1260

gctatactta gaaggcagga ggatttttat ccgttcctca aagacaatcg tgaaaagatt     1320

gagaaaatcc taacctttcg cataccttac tatgtgggac ccctggcccg agggaactct     1380

cggttcgcat ggatgacaag aaagtccgaa gaaacgatta ctccatggaa ttttgaggaa     1440

gttgtcgata aaggtgcgtc agctcaatcg ttcatcgaga ggatgaccaa ctttgacaag     1500

aatttaccga acgaaaaagt attgcctaag cacagtttac tttacgagta tttcacagtg     1560

tacaatgaac tcacgaaagt taagtatgtc actgagggca tgcgtaaacc cgcctttcta     1620

agcggagaac agaagaaagc aatagtagat ctgttattca agaccaaccg caaagtgaca     1680

gttaagcaat tgaaagagga ctactttaag aaaattgaat gcttcgattc tgtcgagatc     1740

tccggggtag aagatcgatt taatgcgtca cttggtacgt atcatgacct cctaaagata     1800

attaaagata aggacttcct ggataacgaa gagaatgaag atatcttaga agatatagtg     1860

ttgactctta ccctctttga agatcgggaa atgattgagg aaagactaaa aacatacgct     1920

cacctgttcg acgataaggt tatgaaacag ttaaagaggc gtcgctatac gggctgggga     1980

cgattgtcgc ggaaacttat caacgggata agagacaagc aaagtggtaa aactattctc     2040

gattttctaa agagcgacgg cttcgccaat aggaacttta tgcagctgat ccatgatgac     2100

tctttaacct tcaaagagga tatacaaaag gcacaggttt ccggacaagg ggactcattg     2160

cacgaacata ttgcgaatct tgctggttcg ccagccatca aaaagggcat actccagaca     2220

gtcaaagtag tggatgagct agttaaggtc atgggacgtc acaaaccgga aaacattgta     2280

atcgagatgg cacgcgaaaa tcaaacgact cagaaggggc aaaaaaacag tcgagagcgg     2340

atgaagagaa tagaagaggg tattaaagaa ctgggcagcc agatcttaaa ggagcatcct     2400

gtggaaaata cccaattgca gaacgagaaa ctttacctct attacctaca aaatggaagg     2460

gacatgtatg ttgatcagga actggacata aaccgtttat ctgattacga cgtcgatcac     2520

attgtacccc aatccttttt gaaggacgat tcaatcgaca ataaagtgct tacacgctcg     2580

gataagaacc gagggaaaag tgacaatgtt ccaagcgagg aagtcgtaaa gaaaatgaag     2640

aactattggc ggcagctcct aaatgcgaaa ctgataacgc aaagaaagtt cgataactta     2700

actaaagctg agaggggtgg cttgtctgaa cttgacaagg ccggatttat taaacgtcag     2760

ctcgtggaaa cccgccaaat cacaaagcat gttgcacaga tactagattc ccgaatgaat     2820

acgaaatacg acgagaacga taagctgatt cgggaagtca aagtaatcac tttaaagtca     2880

aaattggtgt cggacttcag aaaggatttt caattctata aagttaggga gataaataac     2940

taccaccatg cgcacgacgc ttatcttaat gccgtcgtag ggaccgcact cattaagaaa     3000

tacccgaagc tagaaagtga gtttgtgtat ggtgattaca aagtttatga cgtccgtaag     3060

atgatcgcga aaagcgaaca ggagataggc aaggctacag ccaaatactt cttttattct     3120

aacattatga atttctttaa gacggaaatc actctggcaa acggagagat acgcaaacga     3180

cctttaattg aaaccaatgg ggagacaggt gaaatcgtat gggataaggg ccgggacttc     3240

gcgacggtga gaaaagtttt gtccatgccc caagtcaaca tagtaaagaa aactgaggtg     3300

cagaccggag ggttttcaaa ggaatcgatt cttccaaaaa ggaatagtga taagctcatc     3360

gctcgtaaaa aggactggga cccgaaaaag tacggtggct tcgatagccc tacagttgcc     3420

tattctgtcc tagtagtggc aaaagttgag aagggaaaat ccaagaaact gaagtcagtc     3480

aaagaattat tggggataac gattatggag cgctcgtctt ttgaaaagaa ccccatcgac     3540

ttccttgagg cgaaaggtta caaggaagta aaaaaggatc tcataattaa actaccaaag     3600

tatagtctgt ttgagttaga aaatggccga aaacggatgt tggctagcgc cggagagctt     3660

caaaagggga acgaactcgc actaccgtct aaatacgtga atttcctgta tttagcgtcc     3720

cattacgaga agttgaaagg ttcacctgaa gataacgaac agaagcaact ttttgttgag     3780

cagcacaaac attatctcga cgaaatcata gagcaaattt cggaattcag taagagagtc     3840

atcctagctg atgccaatct ggacaaagta ttaagcgcat acaacaagca cagggataaa     3900

cccatacgtg agcaggcgga aaatattatc catttgttta ctcttaccaa cctcggcgct     3960

ccagccgcat tcaagtattt tgacacaacg atagatcgca aacgatacac ttctaccaag     4020

gaggtgctag acgcgacact gattcaccaa tccatcacgg gattatatga aactcggata     4080

gatttgtcac agcttggggg tgacggatcc cccaagaaga agaggaaagt ctcgagcgac     4140

tacaaagacc atgacggtga ttataaagat catgacatcg attacaagga tgacgatgac     4200

aaggctgcag ga                                                         4212


<210>  10
<211>  1404
<212>  PRT
<213>  Streptococcus pyogenes

<400>  10

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Ser Asp  Tyr Lys Asp 
    1370                 1375                 1380             


His Asp  Gly Asp Tyr Lys Asp  His Asp Ile Asp Tyr  Lys Asp Asp 
    1385                 1390                 1395             


Asp Asp  Lys Ala Ala Gly 
    1400                 


<210>  11
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes

<400>  11
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  12
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  12

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  13
<211>  1378
<212>  PRT
<213>  Lactobacillus fermentum

<400>  13

Met Lys Glu Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Ser Gln Phe Lys Leu Met Arg Ile Lys Gly Lys 
            20                  25                  30          


Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala Ala Glu 
        35                  40                  45              


Arg Arg Thr Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys Trp 
    50                  55                  60                  


Arg Leu His Tyr Leu Asp Glu Ile Phe Ala Pro His Leu Gln Glu Val 
65                  70                  75                  80  


Asp Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu 
                85                  90                  95      


Asp Pro Thr Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp 
            100                 105                 110         


Leu Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg 
        115                 120                 125             


Asp Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val Met Asn Ile 
    130                 135                 140                 


Tyr Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu 
145                 150                 155                 160 


Arg Glu Val Tyr Leu Ala Val His His Ile Val Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp 
            180                 185                 190         


Phe Asp Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln 
        195                 200                 205             


Asn Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile 
    210                 215                 220                 


Gly Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asp Arg Gln Lys 
225                 230                 235                 240 


Ala Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr 
                245                 250                 255     


Lys Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly 
            260                 265                 270         


Tyr Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp 
        275                 280                 285             


Lys Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe 
    290                 295                 300                 


Arg Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr 
305                 310                 315                 320 


Ser Leu Phe Ser Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met 
                325                 330                 335     


Ser Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gln 
            340                 345                 350         


Leu Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg 
        355                 360                 365             


Lys Glu Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys 
    370                 375                 380                 


Glu Arg Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys 
385                 390                 395                 400 


Lys Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe 
                405                 410                 415     


Leu Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met 
            420                 425                 430         


His Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr 
        435                 440                 445             


Pro Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His 
    450                 455                 460                 


Gln Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly 
                485                 490                 495     


Ala Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro 
            500                 505                 510         


Trp Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe 
        515                 520                 525             


Ile Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val 
    530                 535                 540                 


Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu 
545                 550                 555                 560 


Leu Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys 
                565                 570                 575     


Gln Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Ala 
            580                 585                 590         


Ser Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys 
        595                 600                 605             


Pro Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu 
    610                 615                 620                 


Ala Thr Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp 
625                 630                 635                 640 


Asn Arg Tyr Gln Thr Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val 
                645                 650                 655     


Phe Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp 
            660                 665                 670         


Leu Thr Asp Glu Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly 
        675                 680                 685             


Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn 
    690                 695                 700                 


Gly Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln Asn Phe Lys 
705                 710                 715                 720 


Glu Ile Val Asp Gln Pro Val Phe Lys Glu Gln Ile Asp Gln Leu Asn 
                725                 730                 735     


Gln Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu Arg Val Glu 
            740                 745                 750         


Ser Val Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
        755                 760                 765             


Trp Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn 
    770                 775                 780                 


Ala Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu Gly Asn Lys 
785                 790                 795                 800 


Gly Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys Leu Phe Glu 
                805                 810                 815     


Asp Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr Glu Glu Leu 
            820                 825                 830         


Glu Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Phe Tyr Phe Thr Gln 
        835                 840                 845             


Gly Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe Asp Glu Ile 
    850                 855                 860                 


Ser Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Val Lys 
865                 870                 875                 880 


Asp Asn Ser Leu Asp Asn Arg Val Leu Thr Ser Arg Lys Glu Asn Asn 
                885                 890                 895     


Lys Lys Ser Asp Gln Val Pro Ala Lys Leu Tyr Ala Ala Lys Met Lys 
            900                 905                 910         


Pro Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr Gln Arg Lys 
        915                 920                 925             


Phe Glu Asn Leu Thr Lys Asp Val Asp Gln Asn Ile Lys Tyr Arg Ser 
    930                 935                 940                 


Leu Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln Val Ile Lys 
945                 950                 955                 960 


Leu Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala Gly Thr Glu 
                965                 970                 975     


Ile Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg Glu Glu Phe 
            980                 985                 990         


Asp Leu Pro Lys Val Arg Glu Val  Asn Asp Tyr His His  Ala Val Asp 
        995                 1000                 1005             


Ala Tyr  Leu Thr Thr Phe Ala  Gly Gln Tyr Leu Asn  Arg Arg Tyr 
    1010                 1015                 1020             


Pro Lys  Leu Arg Ser Phe Phe  Val Tyr Gly Glu Tyr  Met Lys Phe 
    1025                 1030                 1035             


Lys His  Gly Ser Asp Leu Lys  Leu Arg Asn Phe Asn  Phe Phe His 
    1040                 1045                 1050             


Glu Leu  Met Glu Gly Asp Lys  Ser Gln Gly Lys Val  Val Asp Gln 
    1055                 1060                 1065             


Gln Thr  Gly Glu Leu Ile Thr  Thr Arg Asp Glu Val  Ala Lys Ser 
    1070                 1075                 1080             


Phe Asp  Arg Leu Leu Asn Met  Lys Tyr Met Leu Val  Ser Lys Glu 
    1085                 1090                 1095             


Val His  Asp Arg Ser Asp Gln  Leu Tyr Gly Ala Thr  Ile Val Thr 
    1100                 1105                 1110             


Ala Lys  Glu Ser Gly Lys Leu  Thr Ser Pro Ile Glu  Ile Lys Lys 
    1115                 1120                 1125             


Asn Arg  Leu Val Asp Leu Tyr  Gly Ala Tyr Thr Asn  Gly Thr Ser 
    1130                 1135                 1140             


Ala Phe  Met Thr Ile Ile Lys  Phe Thr Gly Asn Lys  Pro Lys Tyr 
    1145                 1150                 1155             


Lys Val  Ile Gly Ile Pro Thr  Thr Ser Ala Ala Ser  Leu Lys Arg 
    1160                 1165                 1170             


Ala Gly  Lys Pro Gly Ser Glu  Ser Tyr Asn Gln Glu  Leu His Arg 
    1175                 1180                 1185             


Ile Ile  Lys Ser Asn Pro Lys  Val Lys Lys Gly Phe  Glu Ile Val 
    1190                 1195                 1200             


Val Pro  His Val Ser Tyr Gly  Gln Leu Ile Val Asp  Gly Asp Cys 
    1205                 1210                 1215             


Lys Phe  Thr Leu Ala Ser Pro  Thr Val Gln His Pro  Ala Thr Gln 
    1220                 1225                 1230             


Leu Val  Leu Ser Lys Lys Ser  Leu Glu Thr Ile Ser  Ser Gly Tyr 
    1235                 1240                 1245             


Lys Ile  Leu Lys Asp Lys Pro  Ala Ile Ala Asn Glu  Arg Leu Ile 
    1250                 1255                 1260             


Arg Val  Phe Asp Glu Val Val  Gly Gln Met Asn Arg  Tyr Phe Thr 
    1265                 1270                 1275             


Ile Phe  Asp Gln Arg Ser Asn  Arg Gln Lys Val Ala  Asp Ala Arg 
    1280                 1285                 1290             


Asp Lys  Phe Leu Ser Leu Pro  Thr Glu Ser Lys Tyr  Glu Gly Ala 
    1295                 1300                 1305             


Lys Lys  Val Gln Val Gly Lys  Thr Glu Val Ile Thr  Asn Leu Leu 
    1310                 1315                 1320             


Met Gly  Leu His Ala Asn Ala  Thr Gln Gly Asp Leu  Lys Val Leu 
    1325                 1330                 1335             


Gly Leu  Ala Thr Phe Gly Phe  Phe Gln Ser Thr Thr  Gly Leu Ser 
    1340                 1345                 1350             


Leu Ser  Glu Asp Thr Met Ile  Val Tyr Gln Ser Pro  Thr Gly Leu 
    1355                 1360                 1365             


Phe Glu  Arg Arg Ile Cys Leu  Lys Asp Ile 
    1370                 1375             


<210>  14
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  14

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  15
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  15

Met Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser 
1               5                   10                  15      


Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala 
            20                  25                  30          


Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg 
        35                  40                  45              


Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg 
    50                  55                  60                  


Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp 
65                  70                  75                  80  


His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly 
                85                  90                  95      


Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His 
            100                 105                 110         


Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp 
        115                 120                 125             


Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys 
    130                 135                 140                 


Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys 
145                 150                 155                 160 


Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp 
                165                 170                 175     


Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His 
            180                 185                 190         


Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr 
        195                 200                 205             


Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu 
                245                 250                 255     


Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu 
            260                 265                 270         


Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly 
305                 310                 315                 320 


Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile 
                325                 330                 335     


Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile 
            340                 345                 350         


Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu 
        355                 360                 365             


Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile 
    370                 375                 380                 


Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala 
385                 390                 395                 400 


Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile 
                405                 410                 415     


Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser 
            420                 425                 430         


Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala 
    450                 455                 460                 


Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr 
            500                 505                 510         


Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His 
        515                 520                 525             


Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr 
            580                 585                 590         


Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His 
        595                 600                 605             


Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys 
625                 630                 635                 640 


Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly 
                645                 650                 655     


Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val 
            660                 665                 670         


Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys 
705                 710                 715                 720 


Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu 
                725                 730                 735     


Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys 
            740                 745                 750         


Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys 
        755                 760                 765             


Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu 
    770                 775                 780                 


Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr 
785                 790                 795                 800 


Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys 
                805                 810                 815     


Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His 
            820                 825                 830         


His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr 
        835                 840                 845             


Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn 
    850                 855                 860                 


Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys 
865                 870                 875                 880 


Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp 
                885                 890                 895     


Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro 
            900                 905                 910         


Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr 
        915                 920                 925             


Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn 
    930                 935                 940                 


Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln 
945                 950                 955                 960 


Ala Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn 
                965                 970                 975     


Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg 
            980                 985                 990         


Ile Glu Val Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
        995                 1000                 1005             


Met Asn  Asp Lys Arg Pro Pro  His Ile Ile Lys Thr  Ile Ala Ser 
    1010                 1015                 1020             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1025                 1030                 1035             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1040                 1045                 1050             


<210>  16
<211>  1409
<212>  PRT
<213>  Streptococcus thermophilus

<400>  16

Met Leu Phe Asn Lys Cys Ile Ile Ile Ser Ile Asn Leu Asp Phe Ser 
1               5                   10                  15      


Asn Lys Glu Lys Cys Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile 
            20                  25                  30          


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val 
        35                  40                  45              


Pro Ser Lys Lys Met Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile 
    50                  55                  60                  


Lys Lys Asn Leu Leu Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala 
65                  70                  75                  80  


Glu Gly Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
                85                  90                  95      


Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala 
            100                 105                 110         


Thr Leu Asp Asp Ala Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val 
        115                 120                 125             


Pro Asp Asp Lys Arg Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val 
    130                 135                 140                 


Glu Glu Lys Val Tyr His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg 
145                 150                 155                 160 


Lys Tyr Leu Ala Asp Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr 
                165                 170                 175     


Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu 
            180                 185                 190         


Gly Glu Phe Asn Ser Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp 
        195                 200                 205             


Phe Leu Asp Thr Tyr Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu 
    210                 215                 220                 


Asn Ser Lys Gln Leu Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu 
225                 230                 235                 240 


Glu Lys Lys Asp Arg Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser 
                245                 250                 255     


Gly Ile Phe Ser Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp 
            260                 265                 270         


Phe Arg Lys Cys Phe Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser 
        275                 280                 285             


Lys Glu Ser Tyr Asp Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly 
    290                 295                 300                 


Asp Asp Tyr Ser Asp Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala 
305                 310                 315                 320 


Ile Leu Leu Ser Gly Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala 
                325                 330                 335     


Pro Leu Ser Ser Ala Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp 
            340                 345                 350         


Leu Ala Leu Leu Lys Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr 
        355                 360                 365             


Asn Glu Val Phe Lys Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Lys Thr Asn Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu 
385                 390                 395                 400 


Leu Ala Glu Phe Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
            420                 425                 430         


Tyr Gln Ile His Leu Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala 
        435                 440                 445             


Lys Phe Tyr Pro Phe Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
465                 470                 475                 480 


Ser Asp Phe Ala Trp Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro 
                485                 490                 495     


Trp Asn Phe Glu Asp Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe 
            500                 505                 510         


Ile Asn Arg Met Thr Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu 
    530                 535                 540                 


Leu Thr Lys Val Arg Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe 
545                 550                 555                 560 


Leu Asp Ser Lys Gln Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp 
                565                 570                 575     


Lys Arg Lys Val Thr Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile 
            580                 585                 590         


Tyr Gly Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn 
        595                 600                 605             


Ser Ser Leu Ser Thr Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys 
    610                 615                 620                 


Glu Phe Leu Asp Asp Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile 
625                 630                 635                 640 


His Thr Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu 
                645                 650                 655     


Ser Lys Phe Glu Asn Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser 
            660                 665                 670         


Arg Arg His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Glu Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile 
    690                 695                 700                 


Asp Asp Gly Ile Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ala Leu Ser Phe Lys Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp 
                725                 730                 735     


Glu Asp Lys Gly Asn Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser 
            740                 745                 750         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu 
        755                 760                 765             


Leu Val Lys Val Met Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu 
    770                 775                 780                 


Met Ala Arg Glu Asn Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln 
785                 790                 795                 800 


Gln Arg Leu Lys Arg Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys 
                805                 810                 815     


Ile Leu Lys Glu Asn Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn 
            820                 825                 830         


Ala Leu Gln Asn Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
        835                 840                 845             


Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr 
    850                 855                 860                 


Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
865                 870                 875                 880 


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp 
                885                 890                 895     


Asp Phe Pro Ser Leu Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr 
            900                 905                 910         


Gln Leu Leu Lys Ser Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu 
        915                 920                 925             


Thr Lys Ala Glu Arg Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe 
    930                 935                 940                 


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
945                 950                 955                 960 


Arg Leu Leu Asp Glu Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg 
                965                 970                 975     


Ala Val Arg Thr Val Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser 
            980                 985                 990         


Gln Phe Arg Lys Asp Phe Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp 
        995                 1000                 1005             


Phe His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Ile Ala Ser 
    1010                 1015                 1020             


Ala Leu  Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
    1025                 1030                 1035             


Gly Asp  Tyr Pro Lys Tyr Asn  Ser Phe Arg Glu Arg  Lys Ser Ala 
    1040                 1045                 1050             


Thr Glu  Lys Val Tyr Phe Tyr  Ser Asn Ile Met Asn  Ile Phe Lys 
    1055                 1060                 1065             


Lys Ser  Ile Ser Leu Ala Asp  Gly Arg Val Ile Glu  Arg Pro Leu 
    1070                 1075                 1080             


Ile Glu  Val Asn Glu Glu Thr  Gly Glu Ser Val Trp  Asn Lys Glu 
    1085                 1090                 1095             


Ser Asp  Leu Ala Thr Val Arg  Arg Val Leu Ser Tyr  Pro Gln Val 
    1100                 1105                 1110             


Asn Val  Val Lys Lys Val Glu  Glu Gln Asn His Gly  Leu Asp Arg 
    1115                 1120                 1125             


Gly Lys  Pro Lys Gly Leu Phe  Asn Ala Asn Leu Ser  Ser Lys Pro 
    1130                 1135                 1140             


Lys Pro  Asn Ser Asn Glu Asn  Leu Val Gly Ala Lys  Glu Tyr Leu 
    1145                 1150                 1155             


Asp Pro  Lys Lys Tyr Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Phe 
    1160                 1165                 1170             


Ala Val  Leu Val Lys Gly Thr  Ile Glu Lys Gly Ala  Lys Lys Lys 
    1175                 1180                 1185             


Ile Thr  Asn Val Leu Glu Phe  Gln Gly Ile Ser Ile  Leu Asp Arg 
    1190                 1195                 1200             


Ile Asn  Tyr Arg Lys Asp Lys  Leu Asn Phe Leu Leu  Glu Lys Gly 
    1205                 1210                 1215             


Tyr Lys  Asp Ile Glu Leu Ile  Ile Glu Leu Pro Lys  Tyr Ser Leu 
    1220                 1225                 1230             


Phe Glu  Leu Ser Asp Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu 
    1235                 1240                 1245             


Ser Thr  Asn Asn Lys Arg Gly  Glu Ile His Lys Gly  Asn Gln Ile 
    1250                 1255                 1260             


Phe Leu  Ser Gln Lys Phe Val  Lys Leu Leu Tyr His  Ala Lys Arg 
    1265                 1270                 1275             


Ile Ser  Asn Thr Ile Asn Glu  Asn His Arg Lys Tyr  Val Glu Asn 
    1280                 1285                 1290             


His Lys  Lys Glu Phe Glu Glu  Leu Phe Tyr Tyr Ile  Leu Glu Phe 
    1295                 1300                 1305             


Asn Glu  Asn Tyr Val Gly Ala  Lys Lys Asn Gly Lys  Leu Leu Asn 
    1310                 1315                 1320             


Ser Ala  Phe Gln Ser Trp Gln  Asn His Ser Ile Asp  Glu Leu Cys 
    1325                 1330                 1335             


Ser Ser  Phe Ile Gly Pro Thr  Gly Ser Glu Arg Lys  Gly Leu Phe 
    1340                 1345                 1350             


Glu Leu  Thr Ser Arg Gly Ser  Ala Ala Asp Phe Glu  Phe Leu Gly 
    1355                 1360                 1365             


Val Lys  Ile Pro Arg Tyr Arg  Asp Tyr Thr Pro Ser  Ser Leu Leu 
    1370                 1375                 1380             


Lys Asp  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1385                 1390                 1395             


Thr Arg  Ile Asp Leu Ala Lys  Leu Gly Glu Gly 
    1400                 1405                 


<210>  17
<211>  1402
<212>  PRT
<213>  Lactobacillus crispatus

<400>  17

Met Lys Ile Lys Asn Tyr Asn Leu Ala Leu Thr Pro Ser Thr Ser Ala 
1               5                   10                  15      


Val Gly His Val Glu Val Asp Asp Asp Leu Asn Ile Leu Glu Pro Val 
            20                  25                  30          


His His Gln Lys Ala Ile Gly Val Ala Lys Phe Gly Glu Gly Glu Thr 
        35                  40                  45              


Ala Glu Ala Arg Arg Leu Ala Arg Ser Ala Arg Arg Thr Thr Lys Arg 
    50                  55                  60                  


Arg Ala Asn Arg Ile Asn His Tyr Phe Asn Glu Ile Met Lys Pro Glu 
65                  70                  75                  80  


Ile Asp Lys Val Asp Pro Leu Met Phe Asp Arg Ile Lys Gln Ala Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Glu Arg Lys Glu Phe Arg Thr Val Ile Phe Asp 
            100                 105                 110         


Arg Pro Asn Ile Ala Ser Tyr Tyr His Asn Gln Phe Pro Thr Ile Trp 
        115                 120                 125             


His Leu Gln Lys Tyr Leu Met Ile Thr Asp Glu Lys Ala Asp Ile Arg 
    130                 135                 140                 


Leu Ile Tyr Trp Ala Leu His Ser Leu Leu Lys His Arg Gly His Phe 
145                 150                 155                 160 


Phe Asn Thr Thr Pro Met Ser Gln Phe Lys Pro Gly Lys Leu Asn Leu 
                165                 170                 175     


Lys Asp Asp Met Leu Ala Leu Asp Asp Tyr Asn Asp Leu Glu Gly Leu 
            180                 185                 190         


Ser Phe Ala Val Ala Asn Ser Pro Glu Ile Glu Lys Val Ile Lys Asp 
        195                 200                 205             


Arg Ser Met His Lys Lys Glu Lys Ile Ala Glu Leu Lys Lys Leu Ile 
    210                 215                 220                 


Val Asn Asp Val Pro Asp Lys Asp Leu Ala Lys Arg Asn Asn Lys Ile 
225                 230                 235                 240 


Ile Thr Gln Ile Val Asn Ala Ile Met Gly Asn Ser Phe His Leu Asn 
                245                 250                 255     


Phe Ile Phe Asp Met Asp Leu Asp Lys Leu Thr Ser Lys Ala Trp Ser 
            260                 265                 270         


Phe Lys Leu Asp Asp Pro Glu Leu Asp Thr Lys Phe Asp Ala Ile Ser 
        275                 280                 285             


Gly Ser Met Thr Asp Asn Gln Ile Gly Ile Phe Glu Thr Leu Gln Lys 
    290                 295                 300                 


Ile Tyr Ser Ala Ile Ser Leu Leu Asp Ile Leu Asn Gly Ser Ser Asn 
305                 310                 315                 320 


Val Val Asp Ala Lys Asn Ala Leu Tyr Asp Lys His Lys Arg Asp Leu 
                325                 330                 335     


Asn Leu Tyr Phe Lys Phe Leu Asn Thr Leu Pro Asp Glu Ile Ala Lys 
            340                 345                 350         


Thr Leu Lys Ala Gly Tyr Thr Leu Tyr Ile Gly Asn Arg Lys Lys Asp 
        355                 360                 365             


Leu Leu Ala Ala Arg Lys Leu Leu Lys Val Asn Val Ala Lys Asn Phe 
    370                 375                 380                 


Ser Gln Asp Asp Phe Tyr Lys Leu Ile Asn Lys Glu Leu Lys Ser Ile 
385                 390                 395                 400 


Asp Lys Gln Gly Leu Gln Thr Arg Phe Ser Glu Lys Val Gly Glu Leu 
                405                 410                 415     


Val Ala Gln Asn Asn Phe Leu Pro Val Gln Arg Ser Ser Asp Asn Val 
            420                 425                 430         


Phe Ile Pro Tyr Gln Leu Asn Ala Ile Thr Phe Asn Lys Ile Leu Glu 
        435                 440                 445             


Asn Gln Gly Lys Tyr Tyr Asp Phe Leu Val Lys Pro Asn Pro Ala Lys 
    450                 455                 460                 


Lys Asp Arg Lys Asn Ala Pro Tyr Glu Leu Ser Gln Leu Met Gln Phe 
465                 470                 475                 480 


Thr Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Pro Glu Glu Gln Val 
                485                 490                 495     


Lys Ser Gly Ile Pro Lys Thr Ser Arg Phe Ala Trp Met Val Arg Lys 
            500                 505                 510         


Asp Asn Gly Ala Ile Thr Pro Trp Asn Phe Tyr Asp Lys Val Asp Ile 
        515                 520                 525             


Glu Ala Thr Ala Asp Lys Phe Ile Lys Arg Ser Ile Ala Lys Asp Ser 
    530                 535                 540                 


Tyr Leu Leu Ser Glu Leu Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
545                 550                 555                 560 


Lys Tyr Glu Val Phe Asn Glu Leu Ser Asn Val Ser Leu Asp Gly Lys 
                565                 570                 575     


Lys Leu Ser Gly Gly Val Lys Gln Ile Leu Phe Asn Glu Val Phe Lys 
            580                 585                 590         


Lys Thr Asn Lys Val Asn Thr Ser Arg Ile Leu Lys Ala Leu Ala Lys 
        595                 600                 605             


His Asn Ile Pro Gly Ser Lys Ile Thr Gly Leu Ser Asn Pro Glu Glu 
    610                 615                 620                 


Phe Thr Ser Ser Leu Gln Thr Tyr Asn Ala Trp Lys Lys Tyr Phe Pro 
625                 630                 635                 640 


Asn Gln Ile Asp Asn Phe Ala Tyr Gln Gln Asp Leu Glu Lys Met Ile 
                645                 650                 655     


Glu Trp Ser Thr Val Phe Glu Asp His Lys Ile Leu Ala Lys Lys Leu 
            660                 665                 670         


Asp Glu Ile Glu Trp Leu Asp Asp Asp Gln Lys Lys Phe Val Ala Asn 
        675                 680                 685             


Thr Arg Leu Arg Gly Trp Gly Arg Leu Ser Lys Arg Leu Leu Thr Gly 
    690                 695                 700                 


Leu Lys Asp Asn Tyr Gly Lys Ser Ile Met Gln Arg Leu Glu Thr Thr 
705                 710                 715                 720 


Lys Ala Asn Phe Gln Gln Ile Val Tyr Lys Pro Glu Phe Arg Glu Gln 
                725                 730                 735     


Ile Asp Lys Ile Ser Gln Ala Ala Ala Lys Asn Gln Ser Leu Glu Asp 
            740                 745                 750         


Ile Leu Ala Asn Ser Tyr Thr Ser Pro Ser Asn Arg Lys Ala Ile Arg 
        755                 760                 765             


Lys Thr Met Ser Val Val Asp Glu Tyr Ile Lys Leu Asn His Gly Lys 
    770                 775                 780                 


Glu Pro Asp Lys Ile Phe Leu Met Phe Gln Arg Ser Glu Gln Glu Lys 
785                 790                 795                 800 


Gly Lys Gln Thr Glu Ala Arg Ser Lys Gln Leu Asn Arg Ile Leu Ser 
                805                 810                 815     


Gln Leu Lys Ala Asp Lys Ser Ala Asn Lys Leu Phe Ser Lys Gln Leu 
            820                 825                 830         


Ala Asp Glu Phe Ser Asn Ala Ile Lys Lys Ser Lys Tyr Lys Leu Asn 
        835                 840                 845             


Asp Lys Gln Tyr Phe Tyr Phe Gln Gln Leu Gly Arg Asp Ala Leu Thr 
    850                 855                 860                 


Gly Glu Val Ile Asp Tyr Asp Glu Leu Tyr Lys Tyr Thr Val Leu His 
865                 870                 875                 880 


Ile Ile Pro Arg Ser Lys Leu Thr Asp Asp Ser Gln Asn Asn Lys Val 
                885                 890                 895     


Leu Thr Lys Tyr Lys Ile Val Asp Gly Ser Val Ala Leu Lys Phe Gly 
            900                 905                 910         


Asn Ser Tyr Ser Asp Ala Leu Gly Met Pro Ile Lys Ala Phe Trp Thr 
        915                 920                 925             


Glu Leu Asn Arg Leu Lys Leu Ile Pro Lys Gly Lys Leu Leu Asn Leu 
    930                 935                 940                 


Thr Thr Asp Phe Ser Thr Leu Asn Lys Tyr Gln Arg Asp Gly Tyr Ile 
945                 950                 955                 960 


Ala Arg Gln Leu Val Glu Thr Gln Gln Ile Val Lys Leu Leu Ala Thr 
                965                 970                 975     


Ile Met Gln Ser Arg Phe Lys His Thr Lys Ile Ile Glu Val Arg Asn 
            980                 985                 990         


Ser Gln Val Ala Asn Ile Arg Tyr  Gln Phe Asp Tyr Phe  Arg Ile Lys 
        995                 1000                 1005             


Asn Leu  Asn Glu Tyr Tyr Arg  Gly Phe Asp Ala Tyr  Leu Ala Ala 
    1010                 1015                 1020             


Val Val  Gly Thr Tyr Leu Tyr  Lys Val Tyr Pro Lys  Ala Arg Arg 
    1025                 1030                 1035             


Leu Phe  Val Tyr Gly Gln Tyr  Leu Lys Pro Lys Lys  Thr Asn Gln 
    1040                 1045                 1050             


Glu Asn  Gln Asp Met His Leu  Asp Ser Glu Lys Lys  Ser Gln Gly 
    1055                 1060                 1065             


Phe Asn  Phe Leu Trp Asn Leu  Leu Tyr Gly Lys Gln  Asp Gln Ile 
    1070                 1075                 1080             


Phe Val  Asn Gly Thr Asp Val  Ile Ala Phe Asn Arg  Lys Asp Leu 
    1085                 1090                 1095             


Ile Thr  Lys Met Asn Thr Val  Tyr Asn Tyr Lys Ser  Gln Lys Ile 
    1100                 1105                 1110             


Ser Leu  Ala Ile Asp Tyr His  Asn Gly Ala Met Phe  Lys Ala Thr 
    1115                 1120                 1125             


Leu Phe  Pro Arg Asn Asp Arg  Asp Thr Ala Lys Thr  Arg Lys Leu 
    1130                 1135                 1140             


Ile Pro  Lys Lys Lys Asp Tyr  Asp Thr Asp Ile Tyr  Gly Gly Tyr 
    1145                 1150                 1155             


Thr Ser  Asn Val Asp Gly Tyr  Met Leu Leu Ala Glu  Ile Ile Lys 
    1160                 1165                 1170             


Arg Asp  Gly Asn Lys Gln Tyr  Gly Phe Tyr Gly Val  Pro Ser Arg 
    1175                 1180                 1185             


Leu Val  Ser Glu Leu Asp Thr  Leu Lys Lys Thr Arg  Tyr Thr Glu 
    1190                 1195                 1200             


Tyr Glu  Glu Lys Leu Lys Glu  Ile Ile Lys Pro Glu  Leu Gly Val 
    1205                 1210                 1215             


Asp Leu  Lys Lys Ile Lys Lys  Ile Lys Ile Leu Lys  Asn Lys Val 
    1220                 1225                 1230             


Pro Phe  Asn Gln Val Ile Ile  Asp Lys Gly Ser Lys  Phe Phe Ile 
    1235                 1240                 1245             


Thr Ser  Thr Ser Tyr Arg Trp  Asn Tyr Arg Gln Leu  Ile Leu Ser 
    1250                 1255                 1260             


Ala Glu  Ser Gln Gln Thr Leu  Met Asp Leu Val Val  Asp Pro Asp 
    1265                 1270                 1275             


Phe Ser  Asn His Lys Ala Arg  Lys Asp Ala Arg Lys  Asn Ala Asp 
    1280                 1285                 1290             


Glu Arg  Leu Ile Lys Val Tyr  Glu Glu Ile Leu Tyr  Gln Val Lys 
    1295                 1300                 1305             


Asn Tyr  Met Pro Met Phe Val  Glu Leu His Arg Cys  Tyr Glu Lys 
    1310                 1315                 1320             


Leu Val  Asp Ala Gln Lys Thr  Phe Lys Ser Leu Lys  Ile Ser Asp 
    1325                 1330                 1335             


Lys Ala  Met Val Leu Asn Gln  Ile Leu Ile Leu Leu  His Ser Asn 
    1340                 1345                 1350             


Ala Thr  Ser Pro Val Leu Glu  Lys Leu Gly Tyr His  Thr Arg Phe 
    1355                 1360                 1365             


Thr Leu  Gly Lys Lys His Asn  Leu Ile Ser Glu Asn  Ala Val Leu 
    1370                 1375                 1380             


Val Thr  Gln Ser Ile Thr Gly  Leu Lys Glu Asn His  Val Ser Ile 
    1385                 1390                 1395             


Lys Gln  Met Leu 
    1400         


<210>  18
<211>  1385
<212>  PRT
<213>  Pedicoccus damnosus

<400>  18

Met Thr Asn Glu Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Phe Ala Val Val Asn Asp Asn Asn Arg Val Ile Arg Val Lys 
            20                  25                  30          


Gly Lys Asn Ala Ile Gly Val Arg Leu Phe Asp Glu Gly Lys Ala Ala 
        35                  40                  45              


Ala Asp Arg Arg Ser Phe Arg Thr Thr Arg Arg Ser Phe Arg Thr Thr 
    50                  55                  60                  


Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Lys Leu Leu Arg Glu 
65                  70                  75                  80  


Ile Phe Asp Ala Tyr Ile Thr Pro Val Asp Glu Ala Phe Phe Ile Arg 
                85                  90                  95      


Leu Lys Glu Ser Asn Leu Ser Pro Lys Asp Ser Lys Lys Gln Tyr Ser 
            100                 105                 110         


Gly Asp Ile Leu Phe Asn Asp Arg Ser Asp Lys Asp Phe Tyr Glu Lys 
        115                 120                 125             


Tyr Pro Thr Ile Tyr His Leu Arg Asn Ala Leu Met Thr Glu His Arg 
    130                 135                 140                 


Lys Phe Asp Val Arg Glu Ile Tyr Leu Ala Ile His His Ile Met Lys 
145                 150                 155                 160 


Phe Arg Gly His Phe Leu Asn Ala Thr Pro Ala Asn Asn Phe Lys Val 
                165                 170                 175     


Gly Arg Leu Asn Leu Glu Glu Lys Phe Glu Glu Leu Asn Asp Ile Tyr 
            180                 185                 190         


Gln Arg Val Phe Pro Asp Glu Ser Ile Glu Phe Arg Thr Asp Asn Leu 
        195                 200                 205             


Glu Gln Ile Lys Glu Val Leu Leu Asp Asn Lys Arg Ser Arg Ala Asp 
    210                 215                 220                 


Arg Gln Arg Thr Leu Val Ser Asp Ile Tyr Gln Ser Ser Glu Asp Lys 
225                 230                 235                 240 


Asp Ile Glu Lys Arg Asn Lys Ala Val Ala Thr Glu Ile Leu Lys Ala 
                245                 250                 255     


Ser Leu Gly Asn Lys Ala Lys Leu Asn Val Ile Thr Asn Val Glu Val 
            260                 265                 270         


Asp Lys Glu Ala Ala Lys Glu Trp Ser Ile Thr Phe Asp Ser Glu Ser 
        275                 280                 285             


Ile Asp Asp Asp Leu Ala Lys Ile Glu Gly Gln Met Thr Asp Asp Gly 
    290                 295                 300                 


His Glu Ile Ile Glu Val Leu Arg Ser Leu Tyr Ser Gly Ile Thr Leu 
305                 310                 315                 320 


Ser Ala Ile Val Pro Glu Asn His Thr Leu Ser Gln Ser Met Val Ala 
                325                 330                 335     


Lys Tyr Asp Leu His Lys Asp His Leu Lys Leu Phe Lys Lys Leu Ile 
            340                 345                 350         


Asn Gly Met Thr Asp Thr Lys Lys Ala Lys Asn Leu Arg Ala Ala Tyr 
        355                 360                 365             


Asp Gly Tyr Ile Asp Gly Val Lys Gly Lys Val Leu Pro Gln Glu Asp 
    370                 375                 380                 


Phe Tyr Lys Gln Val Gln Val Asn Leu Asp Asp Ser Ala Glu Ala Asn 
385                 390                 395                 400 


Glu Ile Gln Thr Tyr Ile Asp Gln Asp Ile Phe Met Pro Lys Gln Arg 
                405                 410                 415     


Thr Lys Ala Asn Gly Ser Ile Pro His Gln Leu Gln Gln Gln Glu Leu 
            420                 425                 430         


Asp Gln Ile Ile Glu Asn Gln Lys Ala Tyr Tyr Pro Trp Leu Ala Glu 
        435                 440                 445             


Leu Asn Pro Asn Pro Asp Lys Lys Arg Gln Gln Leu Ala Lys Tyr Lys 
    450                 455                 460                 


Leu Asp Glu Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Met 
465                 470                 475                 480 


Ile Thr Ala Lys Asp Gln Lys Asn Gln Ser Gly Ala Glu Phe Ala Trp 
                485                 490                 495     


Met Ile Arg Lys Glu Pro Gly Asn Ile Thr Pro Trp Asn Phe Asp Gln 
            500                 505                 510         


Lys Val Asp Arg Met Ala Thr Ala Asn Gln Phe Ile Lys Arg Met Thr 
        515                 520                 525             


Thr Thr Asp Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Ala Gln Ser 
    530                 535                 540                 


Leu Leu Tyr Gln Lys Phe Glu Val Leu Asn Glu Leu Asn Lys Ile Arg 
545                 550                 555                 560 


Ile Asp His Lys Pro Ile Ser Ile Glu Gln Lys Gln Gln Ile Phe Asn 
                565                 570                 575     


Asp Leu Phe Lys Gln Phe Lys Asn Val Thr Ile Lys His Leu Gln Asp 
            580                 585                 590         


Tyr Leu Val Ser Gln Gly Gln Tyr Ser Lys Arg Pro Leu Ile Glu Gly 
        595                 600                 605             


Leu Ala Asp Glu Lys Arg Phe Asn Ser Ser Leu Ser Thr Tyr Ser Asp 
    610                 615                 620                 


Leu Cys Gly Ile Phe Gly Ala Lys Leu Val Glu Glu Asn Asp Arg Gln 
625                 630                 635                 640 


Glu Asp Leu Glu Lys Ile Ile Glu Trp Ser Thr Ile Phe Glu Asp Lys 
                645                 650                 655     


Lys Ile Tyr Arg Ala Lys Leu Asn Asp Leu Thr Trp Leu Thr Asp Asp 
            660                 665                 670         


Gln Lys Glu Lys Leu Ala Thr Lys Arg Tyr Gln Gly Trp Gly Arg Leu 
        675                 680                 685             


Ser Arg Lys Leu Leu Val Gly Leu Lys Asn Ser Glu His Arg Asn Ile 
    690                 695                 700                 


Met Asp Ile Leu Trp Ile Thr Asn Glu Asn Phe Met Gln Ile Gln Ala 
705                 710                 715                 720 


Glu Pro Asp Phe Ala Lys Leu Val Thr Asp Ala Asn Lys Gly Met Leu 
                725                 730                 735     


Glu Lys Thr Asp Ser Gln Asp Val Ile Asn Asp Leu Tyr Thr Ser Pro 
            740                 745                 750         


Gln Asn Lys Lys Ala Ile Arg Gln Ile Leu Leu Val Val His Asp Ile 
        755                 760                 765             


Gln Asn Ala Met His Gly Gln Ala Pro Ala Lys Ile His Val Glu Phe 
    770                 775                 780                 


Ala Arg Gly Glu Glu Arg Asn Pro Arg Arg Ser Val Gln Arg Gln Arg 
785                 790                 795                 800 


Gln Val Glu Ala Ala Tyr Glu Lys Val Ser Asn Glu Leu Val Ser Ala 
                805                 810                 815     


Lys Val Arg Gln Glu Phe Lys Glu Ala Ile Asn Asn Lys Arg Asp Phe 
            820                 825                 830         


Lys Asp Arg Leu Phe Leu Tyr Phe Met Gln Gly Gly Ile Asp Ile Tyr 
        835                 840                 845             


Thr Gly Lys Gln Leu Asn Ile Asp Gln Leu Ser Ser Tyr Gln Ile Asp 
    850                 855                 860                 


His Ile Leu Pro Gln Ala Phe Val Lys Asp Asp Ser Leu Thr Asn Arg 
865                 870                 875                 880 


Val Leu Thr Asn Glu Asn Gln Val Lys Ala Asp Ser Val Pro Ile Asp 
                885                 890                 895     


Ile Phe Gly Lys Lys Met Leu Ser Val Trp Gly Arg Met Lys Asp Gln 
            900                 905                 910         


Gly Leu Ile Ser Lys Gly Lys Tyr Arg Asn Leu Thr Met Asn Pro Glu 
        915                 920                 925             


Asn Ile Ser Ala His Thr Glu Asn Gly Phe Ile Asn Arg Gln Leu Val 
    930                 935                 940                 


Glu Thr Arg Gln Val Ile Lys Leu Ala Val Asn Ile Leu Ala Asp Glu 
945                 950                 955                 960 


Tyr Gly Asp Ser Thr Gln Ile Ile Ser Val Lys Ala Asp Leu Ser His 
                965                 970                 975     


Gln Met Arg Glu Asp Phe Glu Leu Leu Lys Asn Arg Asp Val Asn Asp 
            980                 985                 990         


Tyr His His Ala Phe Asp Ala Tyr  Leu Ala Ala Phe Ile  Gly Asn Tyr 
        995                 1000                 1005             


Leu Leu  Lys Arg Tyr Pro Lys  Leu Glu Ser Tyr Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Phe  Lys Lys Phe Thr Gln  Lys Glu Thr Lys Met  Arg Arg Phe 
    1025                 1030                 1035             


Asn Phe  Ile Tyr Asp Leu Lys  His Cys Asp Gln Val  Val Asn Lys 
    1040                 1045                 1050             


Glu Thr  Gly Glu Ile Leu Trp  Thr Lys Asp Glu Asp  Ile Lys Tyr 
    1055                 1060                 1065             


Ile Arg  His Leu Phe Ala Tyr  Lys Lys Ile Leu Val  Ser His Glu 
    1070                 1075                 1080             


Val Arg  Glu Lys Arg Gly Ala  Leu Tyr Asn Gln Thr  Ile Tyr Lys 
    1085                 1090                 1095             


Ala Lys  Asp Asp Lys Gly Ser  Gly Gln Glu Ser Lys  Lys Leu Ile 
    1100                 1105                 1110             


Arg Ile  Lys Asp Asp Lys Glu  Thr Lys Ile Tyr Gly  Gly Tyr Ser 
    1115                 1120                 1125             


Gly Lys  Ser Leu Ala Tyr Met  Thr Ile Val Gln Ile  Thr Lys Lys 
    1130                 1135                 1140             


Asn Lys  Val Ser Tyr Arg Val  Ile Gly Ile Pro Thr  Leu Ala Leu 
    1145                 1150                 1155             


Ala Arg  Leu Asn Lys Leu Glu  Asn Asp Ser Thr Glu  Asn Asn Gly 
    1160                 1165                 1170             


Glu Leu  Tyr Lys Ile Ile Lys  Pro Gln Phe Thr His  Tyr Lys Val 
    1175                 1180                 1185             


Asp Lys  Lys Asn Gly Glu Ile  Ile Glu Thr Thr Asp  Asp Phe Lys 
    1190                 1195                 1200             


Ile Val  Val Ser Lys Val Arg  Phe Gln Gln Leu Ile  Asp Asp Ala 
    1205                 1210                 1215             


Gly Gln  Phe Phe Met Leu Ala  Ser Asp Thr Tyr Lys  Asn Asn Ala 
    1220                 1225                 1230             


Gln Gln  Leu Val Ile Ser Asn  Asn Ala Leu Lys Ala  Ile Asn Asn 
    1235                 1240                 1245             


Thr Asn  Ile Thr Asp Cys Pro  Arg Asp Asp Leu Glu  Arg Leu Asp 
    1250                 1255                 1260             


Asn Leu  Arg Leu Asp Ser Ala  Phe Asp Glu Ile Val  Lys Lys Met 
    1265                 1270                 1275             


Asp Lys  Tyr Phe Ser Ala Tyr  Asp Ala Asn Asn Phe  Arg Glu Lys 
    1280                 1285                 1290             


Ile Arg  Asn Ser Asn Leu Ile  Phe Tyr Gln Leu Pro  Val Glu Asp 
    1295                 1300                 1305             


Gln Trp  Glu Asn Asn Lys Ile  Thr Glu Leu Gly Lys  Arg Thr Val 
    1310                 1315                 1320             


Leu Thr  Arg Ile Leu Gln Gly  Leu His Ala Asn Ala  Thr Thr Thr 
    1325                 1330                 1335             


Asp Met  Ser Ile Phe Lys Ile  Lys Thr Pro Phe Gly  Gln Leu Arg 
    1340                 1345                 1350             


Gln Arg  Ser Gly Ile Ser Leu  Ser Glu Asn Ala Gln  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Ser  Pro Thr Gly Leu Phe  Glu Arg Arg Val Gln  Leu Asn Lys 
    1370                 1375                 1380             


Ile Lys  
    1385 


<210>  19
<211>  1367
<212>  PRT
<213>  Fusobaterium nucleatum

<400>  19

Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Glu Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asn 
65                  70                  75                  80  


Glu Ile Leu Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Ser Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asn Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Val Tyr Leu Ala Ile His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ala Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ile Ile Asp Lys Asn Asn Ile Glu Lys Leu Glu Lys Ile Val Cys 
        195                 200                 205             


Asp Ser Lys Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Gly Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Thr Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ala Asp Ser Gln Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Gly Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Ser Ala Tyr Ile Gly Leu Asn Lys Glu Lys Ser Lys Lys Glu Val 
        355                 360                 365             


Ile Glu Lys Ser Arg Leu Lys Ile Asp Asp Leu Ile Lys Asn Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Val Glu Glu Ile Glu Glu Lys Asp Lys Ala Ile 
385                 390                 395                 400 


Phe Asn Lys Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Ala 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Ile Ile Thr Lys Asp Lys Leu Leu Met Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Thr Phe Leu Tyr Ser Glu Tyr Val Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Lys Gln Ile Val 
            580                 585                 590         


Asp Gly Thr Ile Glu Leu Lys Gly Val Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Ile Ser Tyr Ile Arg Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Thr Lys Asp Glu Ile Lys Lys Ile Asn Thr Phe 
            660                 665                 670         


Lys Phe Asn Asn Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Asp 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asn Asn Glu Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Ala Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Phe Gln Thr Leu Lys Ile Tyr Glu Glu Ile Arg Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Ser Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Ile Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Glu Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Lys  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Val Tyr Asn Gly Lys  Asp Asp Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Leu  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Arg  Ile Lys Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Asn Ile  Lys Asp Glu Lys Ser  Leu Val Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Lys  Leu Val Glu Pro Arg  Val Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asp  Tyr Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Thr Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Asn Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Val  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Ser Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Lys Asp Arg  Tyr Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Leu Glu Ser Val  Lys Asp Arg Tyr Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Met Asn Asn  Lys Lys Tyr Gln Glu  Leu Leu Asp 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  Tyr Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210>  20
<211>  1346
<212>  PRT
<213>  Enterococcus cecorum

<400>  20

Met Asn Lys Tyr Tyr Leu Gly Leu Asp Met Gly Ser Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Glu Asn Tyr His Leu Val Arg Arg Lys Gly Lys 
            20                  25                  30          


Asp Leu Trp Gly Val Arg Thr Phe Asp Val Ala Gln Thr Ala Lys Glu 
        35                  40                  45              


Arg Arg Ile Thr Arg Gly Asn Arg Arg Arg Gln Asp Arg Arg Lys Gln 
    50                  55                  60                  


Arg Ile Gln Ile Leu Gln Glu Leu Leu Gly Glu Glu Val Leu Lys Thr 
65                  70                  75                  80  


Asp Pro Gly Phe Phe His Arg Met Lys Glu Ser Arg Tyr Val Val Glu 
                85                  90                  95      


Asp Lys Arg Thr Leu Asp Gly Lys Gln Val Glu Leu Pro Tyr Ala Leu 
            100                 105                 110         


Phe Val Asp Lys Asp Tyr Thr Asp Lys Glu Tyr Tyr Lys Gln Phe Pro 
        115                 120                 125             


Thr Ile Asn His Leu Ile Val Tyr Leu Met Thr Thr Ser Asp Thr Pro 
    130                 135                 140                 


Asp Ile Arg Leu Val Tyr Leu Ala Leu His Tyr Tyr Met Lys Asn Arg 
145                 150                 155                 160 


Gly Asn Phe Leu His Ser Gly Asp Ile Asn Asn Val Lys Asp Ile Asn 
                165                 170                 175     


Asp Ile Leu Glu Gln Leu Asp Asn Val Leu Glu Thr Phe Leu Asp Gly 
            180                 185                 190         


Trp Asn Leu Lys Leu Lys Ser Tyr Val Glu Asp Ile Lys Asn Ile Tyr 
        195                 200                 205             


Asn Arg Asp Leu Gly Arg Gly Glu Arg Lys Lys Ala Phe Val Asn Thr 
    210                 215                 220                 


Leu Gly Ala Lys Thr Lys Ala Glu Lys Ala Phe Cys Ser Leu Ile Ser 
225                 230                 235                 240 


Gly Gly Ser Thr Asn Leu Ala Glu Leu Phe Asp Asp Ser Ser Leu Lys 
                245                 250                 255     


Glu Ile Glu Thr Pro Lys Ile Glu Phe Ala Ser Ser Ser Leu Glu Asp 
            260                 265                 270         


Lys Ile Asp Gly Ile Gln Glu Ala Leu Glu Asp Arg Phe Ala Val Ile 
        275                 280                 285             


Glu Ala Ala Lys Arg Leu Tyr Asp Trp Lys Thr Leu Thr Asp Ile Leu 
    290                 295                 300                 


Gly Asp Ser Ser Ser Leu Ala Glu Ala Arg Val Asn Ser Tyr Gln Met 
305                 310                 315                 320 


His His Glu Gln Leu Leu Glu Leu Lys Ser Leu Val Lys Glu Tyr Leu 
                325                 330                 335     


Asp Arg Lys Val Phe Gln Glu Val Phe Val Ser Leu Asn Val Ala Asn 
            340                 345                 350         


Asn Tyr Pro Ala Tyr Ile Gly His Thr Lys Ile Asn Gly Lys Lys Lys 
        355                 360                 365             


Glu Leu Glu Val Lys Arg Thr Lys Arg Asn Asp Phe Tyr Ser Tyr Val 
    370                 375                 380                 


Lys Lys Gln Val Ile Glu Pro Ile Lys Lys Lys Val Ser Asp Glu Ala 
385                 390                 395                 400 


Val Leu Thr Lys Leu Ser Glu Ile Glu Ser Leu Ile Glu Val Asp Lys 
                405                 410                 415     


Tyr Leu Pro Leu Gln Val Asn Ser Asp Asn Gly Val Ile Pro Tyr Gln 
            420                 425                 430         


Val Lys Leu Asn Glu Leu Thr Arg Ile Phe Asp Asn Leu Glu Asn Arg 
        435                 440                 445             


Ile Pro Val Leu Arg Glu Asn Arg Asp Lys Ile Ile Lys Thr Phe Lys 
    450                 455                 460                 


Phe Arg Ile Pro Tyr Tyr Val Gly Ser Leu Asn Gly Val Val Lys Asn 
465                 470                 475                 480 


Gly Lys Cys Thr Asn Trp Met Val Arg Lys Glu Glu Gly Lys Ile Tyr 
                485                 490                 495     


Pro Trp Asn Phe Glu Asp Lys Val Asp Leu Glu Ala Ser Ala Glu Gln 
            500                 505                 510         


Phe Ile Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Val Asn Glu Asp 
        515                 520                 525             


Val Leu Pro Lys Tyr Ser Leu Leu Tyr Ser Lys Tyr Leu Val Leu Ser 
    530                 535                 540                 


Glu Leu Asn Asn Leu Arg Ile Asp Gly Arg Pro Leu Asp Val Lys Ile 
545                 550                 555                 560 


Lys Gln Asp Ile Tyr Glu Asn Val Phe Lys Lys Asn Arg Lys Val Thr 
                565                 570                 575     


Leu Lys Lys Ile Lys Lys Tyr Leu Leu Lys Glu Gly Ile Ile Thr Asp 
            580                 585                 590         


Asp Asp Glu Leu Ser Gly Leu Ala Asp Asp Val Lys Ser Ser Leu Thr 
        595                 600                 605             


Ala Tyr Arg Asp Phe Lys Glu Lys Leu Gly His Leu Asp Leu Ser Glu 
    610                 615                 620                 


Ala Gln Met Glu Asn Ile Ile Leu Asn Ile Thr Leu Phe Gly Asp Asp 
625                 630                 635                 640 


Lys Lys Leu Leu Lys Lys Arg Leu Ala Ala Leu Tyr Pro Phe Ile Asp 
                645                 650                 655     


Asp Lys Ser Leu Asn Arg Ile Ala Thr Leu Asn Tyr Arg Asp Trp Gly 
            660                 665                 670         


Arg Leu Ser Glu Arg Phe Leu Ser Gly Ile Thr Ser Val Asp Gln Glu 
        675                 680                 685             


Thr Gly Glu Leu Arg Thr Ile Ile Gln Cys Met Tyr Glu Thr Gln Ala 
    690                 695                 700                 


Asn Leu Met Gln Leu Leu Ala Glu Pro Tyr His Phe Val Glu Ala Ile 
705                 710                 715                 720 


Glu Lys Glu Asn Pro Lys Val Asp Leu Glu Ser Ile Ser Tyr Arg Ile 
                725                 730                 735     


Val Asn Asp Leu Tyr Val Ser Pro Ala Val Lys Arg Gln Ile Trp Gln 
            740                 745                 750         


Thr Leu Leu Val Ile Lys Asp Ile Lys Gln Val Met Lys His Asp Pro 
        755                 760                 765             


Glu Arg Ile Phe Ile Glu Met Ala Arg Glu Lys Gln Glu Ser Lys Lys 
    770                 775                 780                 


Thr Lys Ser Arg Lys Gln Val Leu Ser Glu Val Tyr Lys Lys Ala Lys 
785                 790                 795                 800 


Glu Tyr Glu His Leu Phe Glu Lys Leu Asn Ser Leu Thr Glu Glu Gln 
                805                 810                 815     


Leu Arg Ser Lys Lys Ile Tyr Leu Tyr Phe Thr Gln Leu Gly Lys Cys 
            820                 825                 830         


Met Tyr Ser Gly Glu Pro Ile Asp Phe Glu Asn Leu Val Ser Ala Asn 
        835                 840                 845             


Ser Asn Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Ile Asp 
    850                 855                 860                 


Asp Ser Phe Asn Asn Ile Val Leu Val Lys Lys Ser Leu Asn Ala Tyr 
865                 870                 875                 880 


Lys Ser Asn His Tyr Pro Ile Asp Lys Asn Ile Arg Asp Asn Glu Lys 
                885                 890                 895     


Val Lys Thr Leu Trp Asn Thr Leu Val Ser Lys Gly Leu Ile Thr Lys 
            900                 905                 910         


Glu Lys Tyr Glu Arg Leu Ile Arg Ser Thr Pro Phe Ser Asp Glu Glu 
        915                 920                 925             


Leu Ala Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Arg Gln Ser Thr 
    930                 935                 940                 


Lys Ala Val Ala Glu Ile Leu Ser Asn Trp Phe Pro Glu Ser Glu Ile 
945                 950                 955                 960 


Val Tyr Ser Lys Ala Lys Asn Val Ser Asn Phe Arg Gln Asp Phe Glu 
                965                 970                 975     


Ile Leu Lys Val Arg Glu Leu Asn Asp Cys His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ile Val Val Gly Asn  Ala Tyr His Thr Lys  Phe Thr Asn 
        995                 1000                 1005             


Ser Pro  Tyr Arg Phe Ile Lys  Asn Lys Ala Asn Gln  Glu Tyr Asn 
    1010                 1015                 1020             


Leu Arg  Lys Leu Leu Gln Lys  Val Asn Lys Ile Glu  Ser Asn Gly 
    1025                 1030                 1035             


Val Val  Ala Trp Val Gly Gln  Ser Glu Asn Asn Pro  Gly Thr Ile 
    1040                 1045                 1050             


Ala Thr  Val Lys Lys Val Ile  Arg Arg Asn Thr Val  Leu Ile Ser 
    1055                 1060                 1065             


Arg Met  Val Lys Glu Val Asp  Gly Gln Leu Phe Asp  Leu Thr Leu 
    1070                 1075                 1080             


Met Lys  Lys Gly Lys Gly Gln  Val Pro Ile Lys Ser  Ser Asp Glu 
    1085                 1090                 1095             


Arg Leu  Thr Asp Ile Ser Lys  Tyr Gly Gly Tyr Asn  Lys Ala Thr 
    1100                 1105                 1110             


Gly Ala  Tyr Phe Thr Phe Val  Lys Ser Lys Lys Arg  Gly Lys Val 
    1115                 1120                 1125             


Val Arg  Ser Phe Glu Tyr Val  Pro Leu His Leu Ser  Lys Gln Phe 
    1130                 1135                 1140             


Glu Asn  Asn Asn Glu Leu Leu  Lys Glu Tyr Ile Glu  Lys Asp Arg 
    1145                 1150                 1155             


Gly Leu  Thr Asp Val Glu Ile  Leu Ile Pro Lys Val  Leu Ile Asn 
    1160                 1165                 1170             


Ser Leu  Phe Arg Tyr Asn Gly  Ser Leu Val Arg Ile  Thr Gly Arg 
    1175                 1180                 1185             


Gly Asp  Thr Arg Leu Leu Leu  Val His Glu Gln Pro  Leu Tyr Val 
    1190                 1195                 1200             


Ser Asn  Ser Phe Val Gln Gln  Leu Lys Ser Val Ser  Ser Tyr Lys 
    1205                 1210                 1215             


Leu Lys  Lys Ser Glu Asn Asp  Asn Ala Lys Leu Thr  Lys Thr Ala 
    1220                 1225                 1230             


Thr Glu  Lys Leu Ser Asn Ile  Asp Glu Leu Tyr Asp  Gly Leu Leu 
    1235                 1240                 1245             


Arg Lys  Leu Asp Leu Pro Ile  Tyr Ser Tyr Trp Phe  Ser Ser Ile 
    1250                 1255                 1260             


Lys Glu  Tyr Leu Val Glu Ser  Arg Thr Lys Tyr Ile  Lys Leu Ser 
    1265                 1270                 1275             


Ile Glu  Glu Lys Ala Leu Val  Ile Phe Glu Ile Leu  His Leu Phe 
    1280                 1285                 1290             


Gln Ser  Asp Ala Gln Val Pro  Asn Leu Lys Ile Leu  Gly Leu Ser 
    1295                 1300                 1305             


Thr Lys  Pro Ser Arg Ile Arg  Ile Gln Lys Asn Leu  Lys Asp Thr 
    1310                 1315                 1320             


Asp Lys  Met Ser Ile Ile His  Gln Ser Pro Ser Gly  Ile Phe Glu 
    1325                 1330                 1335             


His Glu  Ile Glu Leu Thr Ser  Leu 
    1340                 1345     


<210>  21
<211>  1312
<212>  PRT
<213>  Anaerostipes hadrus

<400>  21

Met Gln Asn Gly Phe Leu Gly Ile Thr Val Ser Ser Glu Gln Val Gly 
1               5                   10                  15      


Trp Ala Val Thr Asn Pro Lys Tyr Glu Leu Glu Arg Ala Ser Arg Lys 
            20                  25                  30          


Asp Leu Trp Gly Val Arg Leu Phe Asp Lys Ala Glu Thr Ala Glu Asp 
        35                  40                  45              


Arg Arg Met Phe Arg Thr Asn Arg Arg Leu Asn Gln Arg Lys Lys Asn 
    50                  55                  60                  


Arg Ile His Tyr Leu Arg Asp Ile Phe His Glu Glu Val Asn Gln Lys 
65                  70                  75                  80  


Asp Pro Asn Phe Phe Gln Gln Leu Asp Glu Ser Asn Phe Cys Glu Asp 
                85                  90                  95      


Asp Arg Thr Val Glu Phe Asn Phe Asp Thr Asn Leu Tyr Lys Asn Gln 
            100                 105                 110         


Phe Pro Thr Val Tyr His Leu Arg Lys Tyr Leu Met Glu Thr Lys Asp 
        115                 120                 125             


Lys Pro Asp Ile Arg Leu Val Tyr Leu Ala Phe Ser Lys Phe Met Lys 
    130                 135                 140                 


Asn Arg Gly His Phe Leu Tyr Lys Gly Asn Leu Gly Glu Val Met Asp 
145                 150                 155                 160 


Phe Glu Asn Ser Met Lys Gly Phe Cys Glu Ser Leu Glu Lys Phe Asn 
                165                 170                 175     


Ile Asp Phe Pro Thr Leu Ser Asp Glu Gln Val Lys Glu Val Arg Asp 
            180                 185                 190         


Ile Leu Cys Asp His Lys Ile Ala Lys Thr Val Lys Lys Lys Asn Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Val Lys Ser Lys Thr Ala Lys Ala Trp Ile Gly 
    210                 215                 220                 


Leu Phe Cys Gly Cys Ser Val Pro Val Lys Val Leu Phe Gln Asp Ile 
225                 230                 235                 240 


Asp Glu Glu Ile Val Thr Asp Pro Glu Lys Ile Ser Phe Glu Asp Ala 
                245                 250                 255     


Ser Tyr Asp Asp Tyr Ile Ala Asn Ile Glu Lys Gly Val Gly Ile Tyr 
            260                 265                 270         


Tyr Glu Ala Ile Val Ser Ala Lys Met Leu Phe Asp Trp Ser Ile Leu 
        275                 280                 285             


Asn Glu Ile Leu Gly Asp His Gln Leu Leu Ser Asp Ala Met Ile Ala 
    290                 295                 300                 


Glu Tyr Asn Lys His His Asp Asp Leu Lys Arg Leu Gln Lys Ile Ile 
305                 310                 315                 320 


Lys Gly Thr Gly Ser Arg Glu Leu Tyr Gln Asp Ile Phe Ile Asn Asp 
                325                 330                 335     


Val Ser Gly Asn Tyr Val Cys Tyr Val Gly His Ala Lys Thr Met Ser 
            340                 345                 350         


Ser Ala Asp Gln Lys Gln Phe Tyr Thr Phe Leu Lys Asn Arg Leu Lys 
        355                 360                 365             


Asn Val Asn Gly Ile Ser Ser Glu Asp Ala Glu Trp Ile Asp Thr Glu 
    370                 375                 380                 


Ile Lys Asn Gly Thr Leu Leu Pro Lys Gln Thr Lys Arg Asp Asn Ser 
385                 390                 395                 400 


Val Ile Pro His Gln Leu Gln Leu Arg Glu Phe Glu Leu Ile Leu Asp 
                405                 410                 415     


Asn Met Gln Glu Met Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Leu 
            420                 425                 430         


Leu Lys Ile Phe Asn Phe Val Ile Pro Tyr Tyr Val Gly Pro Leu Lys 
        435                 440                 445             


Gly Val Val Arg Lys Gly Glu Ser Thr Asn Trp Met Val Pro Lys Lys 
    450                 455                 460                 


Asp Gly Val Ile His Pro Trp Asn Phe Asp Glu Met Val Asp Lys Glu 
465                 470                 475                 480 


Ala Ser Ala Glu Cys Phe Ile Ser Arg Met Thr Gly Asn Cys Ser Tyr 
                485                 490                 495     


Leu Phe Asn Glu Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Glu Thr 
            500                 505                 510         


Phe Glu Val Leu Asn Glu Leu Asn Pro Leu Lys Ile Asn Gly Glu Pro 
        515                 520                 525             


Ile Ser Val Glu Leu Lys Gln Arg Ile Tyr Glu Gln Leu Phe Leu Thr 
    530                 535                 540                 


Gly Lys Lys Val Thr Lys Lys Ser Leu Thr Lys Tyr Leu Ile Lys Asn 
545                 550                 555                 560 


Gly Tyr Asp Lys Asp Ile Glu Leu Ser Gly Ile Asp Asn Glu Phe His 
                565                 570                 575     


Ser Asn Leu Lys Ser His Ile Asp Phe Glu Asp Tyr Asp Asn Leu Ser 
            580                 585                 590         


Asp Glu Glu Val Glu Gln Ile Ile Leu Arg Ile Thr Val Phe Glu Asp 
        595                 600                 605             


Lys Gln Leu Leu Lys Asp Tyr Leu Asn Arg Glu Phe Val Lys Leu Ser 
    610                 615                 620                 


Glu Asp Glu Arg Lys Gln Ile Cys Ser Leu Ser Tyr Lys Gly Trp Gly 
625                 630                 635                 640 


Asn Leu Ser Glu Met Leu Leu Asn Gly Ile Thr Val Thr Asp Ser Asn 
                645                 650                 655     


Gly Val Glu Val Ser Val Met Asp Met Leu Trp Asn Thr Asn Leu Asn 
            660                 665                 670         


Leu Met Gln Ile Leu Ser Lys Lys Tyr Gly Tyr Lys Ala Glu Ile Glu 
        675                 680                 685             


His Tyr Asn Lys Glu His Glu Lys Thr Ile Tyr Asn Arg Glu Asp Leu 
    690                 695                 700                 


Met Asp Tyr Leu Asn Ile Pro Pro Ala Gln Arg Arg Lys Val Asn Gln 
705                 710                 715                 720 


Leu Ile Thr Ile Val Lys Ser Leu Lys Lys Thr Tyr Gly Val Pro Asn 
                725                 730                 735     


Lys Ile Phe Phe Lys Ile Ser Arg Glu His Gln Asp Asp Pro Lys Arg 
            740                 745                 750         


Thr Ser Ser Arg Lys Glu Gln Leu Lys Tyr Leu Tyr Lys Ser Leu Lys 
        755                 760                 765             


Ser Glu Asp Glu Lys His Leu Met Lys Glu Leu Asp Glu Leu Asn Asp 
    770                 775                 780                 


His Glu Leu Ser Asn Asp Lys Val Tyr Leu Tyr Phe Leu Gln Lys Gly 
785                 790                 795                 800 


Arg Cys Ile Tyr Ser Gly Lys Lys Leu Asn Leu Ser Arg Leu Arg Lys 
                805                 810                 815     


Ser Asn Tyr Gln Asn Asp Ile Asp Tyr Ile Tyr Pro Leu Ser Ala Val 
            820                 825                 830         


Asn Asp Arg Ser Met Asn Asn Lys Val Leu Thr Gly Ile Gln Glu Asn 
        835                 840                 845             


Arg Ala Asp Lys Tyr Thr Tyr Phe Pro Val Asp Ser Glu Ile Gln Lys 
    850                 855                 860                 


Lys Met Lys Gly Phe Trp Met Glu Leu Val Leu Gln Gly Phe Met Thr 
865                 870                 875                 880 


Lys Glu Lys Tyr Phe Arg Leu Ser Arg Glu Asn Asp Phe Ser Lys Ser 
                885                 890                 895     


Glu Leu Val Ser Phe Ile Glu Arg Glu Ile Ser Asp Asn Gln Gln Ser 
            900                 905                 910         


Gly Arg Met Ile Ala Ser Val Leu Gln Tyr Tyr Phe Pro Glu Ser Lys 
        915                 920                 925             


Ile Val Phe Val Lys Glu Lys Leu Ile Ser Ser Phe Lys Arg Asp Phe 
    930                 935                 940                 


His Leu Ile Ser Ser Tyr Gly His Asn His Leu Gln Ala Ala Lys Asp 
945                 950                 955                 960 


Ala Tyr Ile Thr Ile Val Val Gly Asn Val Tyr His Thr Lys Phe Thr 
                965                 970                 975     


Met Asp Pro Ala Ile Tyr Phe Lys Asn His Lys Arg Lys Asp Tyr Asp 
            980                 985                 990         


Leu Asn Arg Leu Phe Leu Glu Asn  Ile Ser Arg Asp Gly  Gln Ile Ala 
        995                 1000                 1005             


Trp Glu  Ser Gly Pro Tyr Gly  Ser Ile Gln Thr Val  Arg Lys Glu 
    1010                 1015                 1020             


Tyr Ala  Gln Asn His Ile Ala  Val Thr Lys Arg Val  Val Glu Val 
    1025                 1030                 1035             


Lys Gly  Gly Leu Phe Lys Gln  Met Pro Leu Lys Lys  Gly His Gly 
    1040                 1045                 1050             


Glu Tyr  Pro Leu Lys Thr Asn  Asp Pro Arg Phe Gly  Asn Ile Ala 
    1055                 1060                 1065             


Gln Tyr  Gly Gly Tyr Thr Asn  Val Thr Gly Ser Tyr  Phe Val Leu 
    1070                 1075                 1080             


Val Glu  Ser Met Glu Lys Gly  Lys Lys Arg Ile Ser  Leu Glu Tyr 
    1085                 1090                 1095             


Val Pro  Val Tyr Leu His Glu  Arg Leu Glu Asp Asp  Pro Gly His 
    1100                 1105                 1110             


Lys Leu  Leu Lys Glu Tyr Leu  Val Asp His Arg Lys  Leu Asn His 
    1115                 1120                 1125             


Pro Lys  Ile Leu Leu Ala Lys  Val Arg Lys Asn Ser  Leu Leu Lys 
    1130                 1135                 1140             


Ile Asp  Gly Phe Tyr Tyr Arg  Leu Asn Gly Arg Ser  Gly Asn Ala 
    1145                 1150                 1155             


Leu Ile  Leu Thr Asn Ala Val  Glu Leu Ile Met Asp  Asp Trp Gln 
    1160                 1165                 1170             


Thr Lys  Thr Ala Asn Lys Ile  Ser Gly Tyr Met Lys  Arg Arg Ala 
    1175                 1180                 1185             


Ile Asp  Lys Lys Ala Arg Val  Tyr Gln Asn Glu Phe  His Ile Gln 
    1190                 1195                 1200             


Glu Leu  Glu Gln Leu Tyr Asp  Phe Tyr Leu Asp Lys  Leu Lys Asn 
    1205                 1210                 1215             


Gly Val  Tyr Lys Asn Arg Lys  Asn Asn Gln Ala Glu  Leu Ile His 
    1220                 1225                 1230             


Asn Glu  Lys Glu Gln Phe Met  Glu Leu Lys Thr Glu  Asp Gln Cys 
    1235                 1240                 1245             


Val Leu  Leu Thr Glu Ile Lys  Lys Leu Phe Val Cys  Ser Pro Met 
    1250                 1255                 1260             


Gln Ala  Asp Leu Thr Leu Ile  Gly Gly Ser Lys His  Thr Gly Met 
    1265                 1270                 1275             


Ile Ala  Met Ser Ser Asn Val  Thr Lys Ala Asp Phe  Ala Val Ile 
    1280                 1285                 1290             


Ala Glu  Asp Pro Leu Gly Leu  Arg Asn Lys Val Ile  Tyr Ser His 
    1295                 1300                 1305             


Lys Gly  Glu Lys 
    1310         


<210>  22
<211>  1344
<212>  PRT
<213>  Kandleria vitulina

<400>  22

Met Ser Gln Asn Asn Asn Lys Ile Tyr Asn Ile Gly Leu Asp Ile Gly 
1               5                   10                  15      


Asp Ala Ser Val Gly Trp Ala Val Val Asp Glu His Tyr Asn Leu Leu 
            20                  25                  30          


Lys Arg His Gly Lys His Met Trp Gly Ser Arg Leu Phe Thr Gln Ala 
        35                  40                  45              


Asn Thr Ala Val Glu Arg Arg Ser Ser Arg Ser Thr Arg Arg Arg Tyr 
    50                  55                  60                  


Asn Lys Arg Arg Glu Arg Ile Arg Leu Leu Arg Glu Ile Met Glu Asp 
65                  70                  75                  80  


Met Val Leu Asp Val Asp Pro Thr Phe Phe Ile Arg Leu Ala Asn Val 
                85                  90                  95      


Ser Phe Leu Asp Gln Glu Asp Lys Lys Asp Tyr Leu Lys Glu Asn Tyr 
            100                 105                 110         


His Ser Asn Tyr Asn Leu Phe Ile Asp Lys Asp Phe Asn Asp Lys Thr 
        115                 120                 125             


Tyr Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Cys 
    130                 135                 140                 


Glu Ser Lys Glu Lys Glu Asp Pro Arg Leu Ile Tyr Leu Ala Leu His 
145                 150                 155                 160 


His Ile Val Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe 
                165                 170                 175     


Ser Met Asp Val Ser Asn Ile Glu Asp Lys Met Ile Asp Val Leu Arg 
            180                 185                 190         


Gln Phe Asn Glu Ile Asn Leu Phe Glu Tyr Val Glu Asp Arg Lys Lys 
        195                 200                 205             


Ile Asp Glu Val Leu Asn Val Leu Lys Glu Pro Leu Ser Lys Lys His 
    210                 215                 220                 


Lys Ala Glu Lys Ala Phe Ala Leu Phe Asp Thr Thr Lys Asp Asn Lys 
225                 230                 235                 240 


Ala Ala Tyr Lys Glu Leu Cys Ala Ala Leu Ala Gly Asn Lys Phe Asn 
                245                 250                 255     


Val Thr Lys Met Leu Lys Glu Ala Glu Leu His Asp Glu Asp Glu Lys 
            260                 265                 270         


Asp Ile Ser Phe Lys Phe Ser Asp Ala Thr Phe Asp Asp Ala Phe Val 
        275                 280                 285             


Glu Lys Gln Pro Leu Leu Gly Asp Cys Val Glu Phe Ile Asp Leu Leu 
    290                 295                 300                 


His Asp Ile Tyr Ser Trp Val Glu Leu Gln Asn Ile Leu Gly Ser Ala 
305                 310                 315                 320 


His Thr Ser Glu Pro Ser Ile Ser Ala Ala Met Ile Gln Arg Tyr Glu 
                325                 330                 335     


Asp His Lys Asn Asp Leu Lys Leu Leu Lys Asp Val Ile Arg Lys Tyr 
            340                 345                 350         


Leu Pro Lys Lys Tyr Phe Glu Val Phe Arg Asp Glu Lys Ser Lys Lys 
        355                 360                 365             


Asn Asn Tyr Cys Asn Tyr Ile Asn His Pro Ser Lys Thr Pro Val Asp 
    370                 375                 380                 


Glu Phe Tyr Lys Tyr Ile Lys Lys Leu Ile Glu Lys Ile Asp Asp Pro 
385                 390                 395                 400 


Asp Val Lys Thr Ile Leu Asn Lys Ile Glu Leu Glu Ser Phe Met Leu 
                405                 410                 415     


Lys Gln Asn Ser Arg Thr Asn Gly Ala Val Pro Tyr Gln Met Gln Leu 
            420                 425                 430         


Asp Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser Val Tyr Tyr Ser Asp 
        435                 440                 445             


Leu Lys Asp Asn Glu Asp Lys Ile Arg Ser Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Phe Gly Pro Leu Asn Ile Thr Lys Asp Arg Gln Phe Asp 
465                 470                 475                 480 


Trp Ile Ile Lys Lys Glu Gly Lys Glu Asn Glu Arg Ile Leu Pro Trp 
                485                 490                 495     


Asn Ala Asn Glu Ile Val Asp Val Asp Lys Thr Ala Asp Glu Phe Ile 
            500                 505                 510         


Lys Arg Met Arg Asn Phe Cys Thr Tyr Phe Pro Asp Glu Pro Val Met 
        515                 520                 525             


Ala Lys Asn Ser Leu Thr Val Ser Lys Tyr Glu Val Leu Asn Glu Ile 
    530                 535                 540                 


Asn Lys Leu Arg Ile Asn Asp His Leu Ile Lys Arg Asp Met Lys Asp 
545                 550                 555                 560 


Lys Met Leu His Thr Leu Phe Met Asp His Lys Ser Ile Ser Ala Asn 
                565                 570                 575     


Ala Met Lys Lys Trp Leu Val Lys Asn Gln Tyr Phe Ser Asn Thr Asp 
            580                 585                 590         


Asp Ile Lys Ile Glu Gly Phe Gln Lys Glu Asn Ala Cys Ser Thr Ser 
        595                 600                 605             


Leu Thr Pro Trp Ile Asp Phe Thr Lys Ile Phe Gly Lys Ile Asn Glu 
    610                 615                 620                 


Ser Asn Tyr Asp Phe Ile Glu Lys Ile Ile Tyr Asp Val Thr Val Phe 
625                 630                 635                 640 


Glu Asp Lys Lys Ile Leu Arg Arg Arg Leu Lys Lys Glu Tyr Asp Leu 
                645                 650                 655     


Asp Glu Glu Lys Ile Lys Lys Ile Leu Lys Leu Lys Tyr Ser Gly Trp 
            660                 665                 670         


Ser Arg Leu Ser Lys Lys Leu Leu Ser Gly Ile Lys Thr Lys Tyr Lys 
        675                 680                 685             


Asp Ser Thr Arg Thr Pro Glu Thr Val Leu Glu Val Met Glu Arg Thr 
    690                 695                 700                 


Asn Met Asn Leu Met Gln Val Ile Asn Asp Glu Lys Leu Gly Phe Lys 
705                 710                 715                 720 


Lys Thr Ile Asp Asp Ala Asn Ser Thr Ser Val Ser Gly Lys Phe Ser 
                725                 730                 735     


Tyr Ala Glu Val Gln Glu Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly 
            740                 745                 750         


Ile Trp Gln Ala Leu Leu Ile Val Asp Glu Ile Lys Lys Ile Met Lys 
        755                 760                 765             


His Glu Pro Ala His Val Tyr Ile Glu Phe Ala Arg Asn Glu Asp Glu 
    770                 775                 780                 


Lys Glu Arg Lys Asp Ser Phe Val Asn Gln Met Leu Lys Leu Tyr Lys 
785                 790                 795                 800 


Asp Tyr Asp Phe Glu Asp Glu Thr Glu Lys Glu Ala Asn Lys His Leu 
                805                 810                 815     


Lys Gly Glu Asp Ala Lys Ser Lys Ile Arg Ser Glu Arg Leu Lys Leu 
            820                 825                 830         


Tyr Tyr Thr Gln Met Gly Lys Cys Met Tyr Thr Gly Lys Ser Leu Asp 
        835                 840                 845             


Ile Asp Arg Leu Asp Thr Tyr Gln Val Asp His Ile Val Pro Gln Ser 
    850                 855                 860                 


Leu Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Leu Ser Ser 
865                 870                 875                 880 


Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Ile Pro Ser Ser Ile Arg 
                885                 890                 895     


Asn Lys Met Tyr Gly Phe Trp Glu Lys Leu Phe Asn Asn Lys Ile Ile 
            900                 905                 910         


Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Thr Glu Phe Asn Glu Lys 
        915                 920                 925             


Asp Gln Glu Arg Phe Ile Asn Arg Gln Ile Val Glu Thr Arg Gln Ile 
    930                 935                 940                 


Thr Lys His Val Ala Gln Ile Ile Asp Asn His Tyr Glu Asn Thr Lys 
945                 950                 955                 960 


Val Val Thr Val Arg Ala Asp Leu Ser His Gln Phe Arg Glu Arg Tyr 
                965                 970                 975     


His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Phe His His Ala His Asp 
            980                 985                 990         


Ala Tyr Ile Ala Thr Ile Leu Gly  Thr Tyr Ile Gly His  Arg Phe Glu 
        995                 1000                 1005             


Ser Leu  Asp Ala Lys Tyr Ile  Tyr Gly Glu Tyr Lys  Arg Ile Phe 
    1010                 1015                 1020             


Arg Asn  Gln Lys Asn Lys Gly  Lys Glu Met Lys Lys  Asn Asn Asp 
    1025                 1030                 1035             


Gly Phe  Ile Leu Asn Ser Met  Arg Asn Ile Tyr Ala  Asp Lys Asp 
    1040                 1045                 1050             


Thr Gly  Glu Ile Val Trp Asp  Pro Asn Tyr Ile Asp  Arg Ile Lys 
    1055                 1060                 1065             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Phe Val Thr Lys  Lys Leu Glu 
    1070                 1075                 1080             


Glu Asn  Asn Gly Thr Phe Phe  Asn Val Thr Val Leu  Pro Asn Asp 
    1085                 1090                 1095             


Thr Asn  Ser Asp Lys Asp Asn  Thr Leu Ala Thr Val  Pro Val Asn 
    1100                 1105                 1110             


Lys Tyr  Arg Ser Asn Val Asn  Lys Tyr Gly Gly Phe  Ser Gly Val 
    1115                 1120                 1125             


Asn Ser  Phe Ile Val Ala Ile  Lys Gly Lys Lys Lys  Lys Gly Lys 
    1130                 1135                 1140             


Lys Val  Ile Glu Val Asn Lys  Leu Thr Gly Ile Pro  Leu Met Tyr 
    1145                 1150                 1155             


Lys Asn  Ala Asp Glu Glu Ile  Lys Ile Asn Tyr Leu  Lys Gln Ala 
    1160                 1165                 1170             


Glu Asp  Leu Glu Glu Val Gln  Ile Gly Lys Glu Ile  Leu Lys Asn 
    1175                 1180                 1185             


Gln Leu  Ile Glu Lys Asp Gly  Gly Leu Tyr Tyr Ile  Val Ala Pro 
    1190                 1195                 1200             


Thr Glu  Ile Ile Asn Ala Lys  Gln Leu Ile Leu Asn  Glu Ser Gln 
    1205                 1210                 1215             


Thr Lys  Leu Val Cys Glu Ile  Tyr Lys Ala Met Lys  Tyr Lys Asn 
    1220                 1225                 1230             


Tyr Asp  Asn Leu Asp Ser Glu  Lys Ile Ile Asp Leu  Tyr Arg Leu 
    1235                 1240                 1245             


Leu Ile  Asn Lys Met Glu Leu  Tyr Tyr Pro Glu Tyr  Arg Lys Gln 
    1250                 1255                 1260             


Leu Val  Lys Lys Phe Glu Asp  Arg Tyr Glu Gln Leu  Lys Val Ile 
    1265                 1270                 1275             


Ser Ile  Glu Glu Lys Cys Asn  Ile Ile Lys Gln Ile  Leu Ala Thr 
    1280                 1285                 1290             


Leu His  Cys Asn Ser Ser Ile  Gly Lys Ile Met Tyr  Ser Asp Phe 
    1295                 1300                 1305             


Lys Ile  Ser Thr Thr Ile Gly  Arg Leu Asn Gly Arg  Thr Ile Ser 
    1310                 1315                 1320             


Leu Asp  Asp Ile Ser Phe Ile  Ala Glu Ser Pro Thr  Gly Met Tyr 
    1325                 1330                 1335             


Ser Lys  Lys Tyr Lys Leu 
    1340                 


<210>  23
<211>  1288
<212>  PRT
<213>  Enterococcus faecalis

<400>  23

Met Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu Lys 
1               5                   10                  15      


Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg Tyr 
            20                  25                  30          


Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn Phe 
        35                  40                  45              


Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys Trp 
    50                  55                  60                  


His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr His 
65                  70                  75                  80  


Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp Ser 
                85                  90                  95      


Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Ile 
            100                 105                 110         


Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr Glu 
        115                 120                 125             


Asn Thr Ser Val Lys Asp Gln Phe Gln Gln Phe Met Val Ile Tyr Asn 
    130                 135                 140                 


Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu Pro 
145                 150                 155                 160 


Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg Thr 
                165                 170                 175     


Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala Asn 
            180                 185                 190         


Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala Asp 
        195                 200                 205             


Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr Ala 
    210                 215                 220                 


Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val Gly 
225                 230                 235                 240 


Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp Ala 
                245                 250                 255     


Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His Ala 
            260                 265                 270         


Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu Asp 
        275                 280                 285             


Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu Tyr 
    290                 295                 300                 


Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr Ile 
305                 310                 315                 320 


Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val Lys 
                325                 330                 335     


Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys Ile 
            340                 345                 350         


Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val 
        355                 360                 365             


Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His Arg 
    370                 375                 380                 


Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile Glu 
385                 390                 395                 400 


Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser Lys 
                405                 410                 415     


Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu Pro 
            420                 425                 430         


Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser Ala 
        435                 440                 445             


Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro Ser 
    450                 455                 460                 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met Val 
465                 470                 475                 480 


Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile Lys 
                485                 490                 495     


Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu Phe 
            500                 505                 510         


Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr Arg 
        515                 520                 525             


Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu Asp 
    530                 535                 540                 


Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys Gly 
545                 550                 555                 560 


Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu Glu 
                565                 570                 575     


Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile Arg 
            580                 585                 590         


Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu Lys 
        595                 600                 605             


Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys 
    610                 615                 620                 


Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu Asp 
625                 630                 635                 640 


Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn Phe 
                645                 650                 655     


Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile Gln 
            660                 665                 670         


Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val Asn 
        675                 680                 685             


Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser Leu 
    690                 695                 700                 


Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys Arg 
705                 710                 715                 720 


Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly Lys 
                725                 730                 735     


Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala Glu 
            740                 745                 750         


Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln Leu 
        755                 760                 765             


Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp Met 
    770                 775                 780                 


Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp Ile 
785                 790                 795                 800 


Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp Asn 
                805                 810                 815     


Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp Val 
            820                 825                 830         


Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys Leu 
        835                 840                 845             


Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr Lys 
    850                 855                 860                 


Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile Gln 
865                 870                 875                 880 


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly Ile 
                885                 890                 895     


Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln Ile 
            900                 905                 910         


Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe Gly 
        915                 920                 925             


Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp Ala 
    930                 935                 940                 


Tyr Leu Asn Cys Val Val Ala Thr Thr Leu Leu Lys Val Tyr Pro Asn 
945                 950                 955                 960 


Leu Ala Pro Glu Phe Val Tyr Gly Glu Tyr Pro Lys Phe Gln Thr Phe 
                965                 970                 975     


Lys Glu Asn Lys Ala Thr Ala Lys Ala Ile Ile Tyr Thr Asn Leu Leu 
            980                 985                 990         


Arg Phe Phe Thr Glu Asp Glu Pro  Arg Phe Thr Lys Asp  Gly Glu Ile 
        995                 1000                 1005             


Leu Trp  Ser Asn Ser Tyr Leu  Lys Thr Ile Lys Lys  Glu Leu Asn 
    1010                 1015                 1020             


Tyr His  Gln Met Asn Ile Val  Lys Lys Val Glu Val  Gln Lys Gly 
    1025                 1030                 1035             


Gly Phe  Ser Lys Glu Ser Ile  Lys Pro Lys Gly Pro  Ser Asn Lys 
    1040                 1045                 1050             


Leu Ile  Pro Val Lys Asn Gly  Leu Asp Pro Gln Lys  Tyr Gly Gly 
    1055                 1060                 1065             


Phe Asp  Ser Pro Val Val Ala  Tyr Thr Val Leu Phe  Thr His Glu 
    1070                 1075                 1080             


Lys Gly  Lys Lys Pro Leu Ile  Lys Gln Glu Ile Leu  Gly Ile Thr 
    1085                 1090                 1095             


Ile Met  Glu Lys Thr Arg Phe  Glu Gln Asn Pro Ile  Leu Phe Leu 
    1100                 1105                 1110             


Glu Glu  Lys Gly Phe Leu Arg  Pro Arg Val Leu Met  Lys Leu Pro 
    1115                 1120                 1125             


Lys Tyr  Thr Leu Tyr Glu Phe  Pro Glu Gly Arg Arg  Arg Leu Leu 
    1130                 1135                 1140             


Ala Ser  Ala Lys Glu Ala Gln  Lys Gly Asn Gln Met  Val Leu Pro 
    1145                 1150                 1155             


Glu His  Leu Leu Thr Leu Leu  Tyr His Ala Lys Gln  Cys Leu Leu 
    1160                 1165                 1170             


Pro Asn  Gln Ser Glu Ser Leu  Ala Tyr Val Glu Gln  His Gln Pro 
    1175                 1180                 1185             


Glu Phe  Gln Glu Ile Leu Glu  Arg Val Val Asp Phe  Ala Glu Val 
    1190                 1195                 1200             


His Thr  Leu Ala Lys Ser Lys  Val Gln Gln Ile Val  Lys Leu Phe 
    1205                 1210                 1215             


Glu Ala  Asn Gln Thr Ala Asp  Val Lys Glu Ile Ala  Ala Ser Phe 
    1220                 1225                 1230             


Ile Gln  Leu Met Gln Phe Asn  Ala Met Gly Ala Pro  Ser Thr Phe 
    1235                 1240                 1245             


Lys Phe  Phe Gln Lys Asp Ile  Glu Arg Ala Arg Tyr  Thr Ser Ile 
    1250                 1255                 1260             


Lys Glu  Ile Phe Asp Ala Thr  Ile Ile Tyr Gln Ser  Pro Thr Gly 
    1265                 1270                 1275             


Leu Tyr  Glu Thr Arg Arg Lys  Val Val Asp 
    1280                 1285             


<210>  24
<211>  1052
<212>  PRT
<213>  Staphylococcus aureus

<400>  24

Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
65                  70                  75                  80  


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
            100                 105                 110         


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
        115                 120                 125             


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
    130                 135                 140                 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
145                 150                 155                 160 


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
                165                 170                 175     


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
            180                 185                 190         


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
        195                 200                 205             


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
    210                 215                 220                 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
                245                 250                 255     


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
            260                 265                 270         


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
        275                 280                 285             


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
    290                 295                 300                 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
305                 310                 315                 320 


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
                325                 330                 335     


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
            340                 345                 350         


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
        355                 360                 365             


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
    370                 375                 380                 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
                405                 410                 415     


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
            420                 425                 430         


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
        435                 440                 445             


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
    450                 455                 460                 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
                485                 490                 495     


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
            500                 505                 510         


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
        515                 520                 525             


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
    530                 535                 540                 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
545                 550                 555                 560 


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
                565                 570                 575     


Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser 
            580                 585                 590         


Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile Leu 
        595                 600                 605             


Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr 
    610                 615                 620                 


Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp Phe 
625                 630                 635                 640 


Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met 
                645                 650                 655     


Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys Val 
            660                 665                 670         


Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys 
        675                 680                 685             


Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
    690                 695                 700                 


Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu 
705                 710                 715                 720 


Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys Gln 
                725                 730                 735     


Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile 
            740                 745                 750         


Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp Tyr 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu Ile 
785                 790                 795                 800 


Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu Lys 
                805                 810                 815     


Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His Asp 
            820                 825                 830         


Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile Lys 
865                 870                 875                 880 


Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp Tyr 
                885                 890                 895     


Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val Lys 
        915                 920                 925             


Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser Lys 
    930                 935                 940                 


Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala Glu 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly Glu 
                965                 970                 975     


Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile Glu 
            980                 985                 990         


Val Asn Met Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
        995                 1000                 1005             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1010                 1015                 1020             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1040                 1045                 1050         


<210>  25
<211>  1082
<212>  PRT
<213>  Geobacillus thermodenitrificans

<400>  25

Met Lys Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Phe Val Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asn Lys Leu Phe Glu Lys Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Ile Leu Leu His Leu Ala Lys Arg Arg Gly Phe Arg 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Thr Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Gln Ser Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Ala Glu Met Val Val Lys Asp Pro Lys Phe Ser Leu His Lys Arg Asn 
                165                 170                 175     


Lys Glu Asp Asn Tyr Thr Asn Thr Val Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Lys Leu Ile Phe Ala Lys Gln Arg Glu Tyr Gly Asn Ile Val 
        195                 200                 205             


Cys Thr Glu Ala Phe Glu His Glu Tyr Ile Ser Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Phe Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Thr Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 
            260                 265                 270         


Pro Gly Gly Ile Arg Ala Leu Thr Asp Asp Glu Arg Arg Leu Ile Tyr 
        275                 280                 285             


Lys Gln Ala Phe His Lys Asn Lys Ile Thr Phe His Asp Val Arg Thr 
    290                 295                 300                 


Leu Leu Asn Leu Pro Asp Asp Thr Arg Phe Lys Gly Leu Leu Tyr Asp 
305                 310                 315                 320 


Arg Asn Thr Thr Leu Lys Glu Asn Glu Lys Val Arg Phe Leu Glu Leu 
                325                 330                 335     


Gly Ala Tyr His Lys Ile Arg Lys Ala Ile Asp Ser Val Tyr Gly Lys 
            340                 345                 350         


Gly Ala Ala Lys Ser Phe Arg Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Met Phe Lys Asp Asp Thr Asp Ile Arg Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Glu Asn Leu Ala Asp Lys 
385                 390                 395                 400 


Val Tyr Asp Glu Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Ser 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Asn Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Thr Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Val Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Glu Leu Ser Gln Ser Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Met Gln Lys Glu Gln Glu Gly Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Val Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


Leu Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Lys Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Ala Glu Tyr Leu Gly Leu Gly Ser Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Asn 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Leu Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Asp Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Ile Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Asn Phe Asn Lys Asn Arg Glu Glu Ser Asn Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Ala Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Arg Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ser 
            740                 745                 750         


Lys Lys Thr Asp Pro Gln Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Gln Ala Arg Leu Ser Lys Asn Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asn Glu Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Ile Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Lys Lys Leu Ser Glu Ile Gln Leu Asp Lys 
        835                 840                 845             


Thr Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Leu Gly 
                885                 890                 895     


Pro Ile Ile Arg Thr Ile Lys Ile Ile Asp Thr Thr Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Ile Tyr 
    930                 935                 940                 


Thr Ile Asp Met Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Phe Pro Arg 
            980                 985                 990         


Glu Lys Thr Ile Lys Thr Ala Val  Gly Glu Glu Ile Lys  Ile Lys Asp 
        995                 1000                 1005             


Leu Phe  Ala Tyr Tyr Gln Thr  Ile Asp Ser Ser Asn  Gly Gly Leu 
    1010                 1015                 1020             


Ser Leu  Val Ser His Asp Asn  Asn Phe Ser Leu Arg  Ser Ile Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Val Ala 
    1055                 1060                 1065             


Ser Ser  Ser His Ser Lys Ala  Gly Glu Thr Ile Arg  Pro Leu 
    1070                 1075                 1080         


<210>  26
<211>  1375
<212>  PRT
<213>  Streptococcus canis

<400>  26

Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210>  27
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (840)..(840)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Met Asp Lys Lys Tyr Ser Ile Gly Leu Xaa Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Xaa Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  28
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  28

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  29
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Met Asp Lys Lys Tyr Ser Ile Gly Leu Xaa Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  30
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (762)..(762)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Xaa Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  31
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (983)..(983)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His Xaa Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  32
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (986)..(986)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Xaa Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  33
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  33

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  34
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  34

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Ala Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  35
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  35

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His Ala Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  36
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  36

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Ala Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  37
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (840)..(840)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Xaa Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  38
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  38

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  39
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (864)..(864)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Xaa 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  40
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  40

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Ala 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  41
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (839)..(839)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Xaa Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  42
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes

<400>  42

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  43
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (863)..(863)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Xaa Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  44
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes

<400>  44

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Ala Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  45
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  45

Met Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser 
1               5                   10                  15      


Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala 
            20                  25                  30          


Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg 
        35                  40                  45              


Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg 
    50                  55                  60                  


Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp 
65                  70                  75                  80  


His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly 
                85                  90                  95      


Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His 
            100                 105                 110         


Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp 
        115                 120                 125             


Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys 
    130                 135                 140                 


Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys 
145                 150                 155                 160 


Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp 
                165                 170                 175     


Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His 
            180                 185                 190         


Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr 
        195                 200                 205             


Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu 
                245                 250                 255     


Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu 
            260                 265                 270         


Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly 
305                 310                 315                 320 


Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile 
                325                 330                 335     


Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile 
            340                 345                 350         


Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu 
        355                 360                 365             


Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile 
    370                 375                 380                 


Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala 
385                 390                 395                 400 


Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile 
                405                 410                 415     


Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser 
            420                 425                 430         


Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala 
    450                 455                 460                 


Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr 
            500                 505                 510         


Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His 
        515                 520                 525             


Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr 
            580                 585                 590         


Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His 
        595                 600                 605             


Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys 
625                 630                 635                 640 


Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly 
                645                 650                 655     


Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val 
            660                 665                 670         


Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys 
705                 710                 715                 720 


Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu 
                725                 730                 735     


Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys 
            740                 745                 750         


Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys 
        755                 760                 765             


Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu 
    770                 775                 780                 


Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr 
785                 790                 795                 800 


Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys 
                805                 810                 815     


Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His 
            820                 825                 830         


His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr 
        835                 840                 845             


Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn 
    850                 855                 860                 


Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys 
865                 870                 875                 880 


Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp 
                885                 890                 895     


Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro 
            900                 905                 910         


Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr 
        915                 920                 925             


Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn 
    930                 935                 940                 


Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln 
945                 950                 955                 960 


Ala Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn 
                965                 970                 975     


Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg 
            980                 985                 990         


Ile Glu Val Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
        995                 1000                 1005             


Met Asn  Asp Lys Arg Pro Pro  His Ile Ile Lys Thr  Ile Ala Ser 
    1010                 1015                 1020             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1025                 1030                 1035             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1040                 1045                 1050             


<210>  46
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis

<400>  46

Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp Ala Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  47
<211>  984
<212>  PRT
<213>  Campylobacter jejuni

<400>  47

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  48
<211>  1087
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  48

Met Arg Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Met Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Gln Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Val Ile Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asp Lys Leu Phe Glu Glu Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Ser Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Arg Ala Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Pro Lys Phe Ala Leu His Lys Arg Asn 
                165                 170                 175     


Lys Gly Glu Asn Tyr Thr Asn Thr Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Arg Leu Ile Phe Ser Lys Gln Arg Glu Phe Gly Asn Met Ser 
        195                 200                 205             


Cys Thr Glu Glu Phe Glu Asn Glu Tyr Ile Thr Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Val Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Ala Trp Glu His Ile Asn Lys Leu Arg Leu Ile Ser 
            260                 265                 270         


Pro Ser Gly Ala Arg Gly Leu Thr Asp Glu Glu Arg Arg Leu Leu Tyr 
        275                 280                 285             


Glu Gln Ala Phe Gln Lys Asn Lys Ile Thr Tyr His Asp Ile Arg Thr 
    290                 295                 300                 


Leu Leu His Leu Pro Asp Asp Thr Tyr Phe Lys Gly Ile Val Tyr Asp 
305                 310                 315                 320 


Arg Gly Glu Ser Arg Lys Gln Asn Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ala Tyr His Gln Ile Arg Lys Ala Val Asp Lys Val Tyr Gly Lys 
            340                 345                 350         


Gly Lys Ser Ser Ser Phe Leu Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Leu Phe Lys Asp Asp Ala Asp Ile His Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Pro Asn Leu Ala Asn Lys 
385                 390                 395                 400 


Val Tyr Asp Asn Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Thr 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Ser Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Ser Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Met Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Asp Leu Ser Gln Thr Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Thr Lys Lys Glu Gln Asp Glu Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Met Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


His Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Arg Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Arg Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Ile Pro Ala Glu Tyr Leu Gly Val Gly Thr Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Thr 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Phe Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Glu Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Val Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Glu Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Val Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Lys Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ala 
            740                 745                 750         


Lys Lys Thr Glu Pro His Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Arg Ala Arg Leu Ser Lys His Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asp Gln Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Val Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu Asp Ala 
        835                 840                 845             


Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro Gly 
                885                 890                 895     


Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val Tyr 
    930                 935                 940                 


Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu Pro Arg 
            980                 985                 990         


Glu Lys Thr Val Lys Thr Ala Ala  Gly Glu Glu Ile Asn  Val Lys Asp 
        995                 1000                 1005             


Val Phe  Val Tyr Tyr Lys Thr  Ile Asp Ser Ala Asn  Gly Gly Leu 
    1010                 1015                 1020             


Glu Leu  Ile Ser His Asp His  Arg Phe Ser Leu Arg  Gly Val Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Leu Ala 
    1055                 1060                 1065             


Ser Ser  Ala His Ser Lys Pro  Gly Lys Thr Ile Arg  Pro Leu Gln 
    1070                 1075                 1080             


Ser Thr  Arg Asp 
    1085         


<210>  49
<211>  1228
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  49

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  50
<211>  1108
<212>  PRT
<213>  Bacillus hisashii

<400>  50

Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Glu Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Tyr Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu Tyr Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Leu Lys Ala Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Val Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Cys Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Val Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210>  51
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp

<400>  51

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  52
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Ala Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  53
<211>  1259
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  53

Met Asn Tyr Lys Thr Gly Leu Glu Asp Phe Ile Gly Lys Glu Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Ser Thr Lys Ile 
            20                  25                  30          


His Met Glu Glu Met Gly Val Ile Arg Asp Asp Glu Leu Arg Ala Glu 
        35                  40                  45              


Lys Gln Gln Glu Leu Lys Glu Ile Met Asp Asp Tyr Tyr Arg Thr Phe 
    50                  55                  60                  


Ile Glu Glu Lys Leu Gly Gln Ile Gln Gly Ile Gln Trp Asn Ser Leu 
65                  70                  75                  80  


Phe Gln Lys Met Glu Glu Thr Met Glu Asp Ile Ser Val Arg Lys Asp 
                85                  90                  95      


Leu Asp Lys Ile Gln Asn Glu Lys Arg Lys Glu Ile Cys Cys Tyr Phe 
            100                 105                 110         


Thr Ser Asp Lys Arg Phe Lys Asp Leu Phe Asn Ala Lys Leu Ile Thr 
        115                 120                 125             


Asp Ile Leu Pro Asn Phe Ile Lys Asp Asn Lys Glu Tyr Thr Glu Glu 
    130                 135                 140                 


Glu Lys Ala Glu Lys Glu Gln Thr Arg Val Leu Phe Gln Arg Phe Ala 
145                 150                 155                 160 


Thr Ala Phe Thr Asn Tyr Phe Asn Gln Arg Arg Asn Asn Phe Ser Glu 
                165                 170                 175     


Asp Asn Ile Ser Thr Ala Ile Ser Phe Arg Ile Val Asn Glu Asn Ser 
            180                 185                 190         


Glu Ile His Leu Gln Asn Met Arg Ala Phe Gln Arg Ile Glu Gln Gln 
        195                 200                 205             


Tyr Pro Glu Glu Val Cys Gly Met Glu Glu Glu Tyr Lys Asp Met Leu 
    210                 215                 220                 


Gln Glu Trp Gln Met Lys His Ile Tyr Ser Val Asp Phe Tyr Asp Arg 
225                 230                 235                 240 


Glu Leu Thr Gln Pro Gly Ile Glu Tyr Tyr Asn Gly Ile Cys Gly Lys 
                245                 250                 255     


Ile Asn Glu His Met Asn Gln Phe Cys Gln Lys Asn Arg Ile Asn Lys 
            260                 265                 270         


Asn Asp Phe Arg Met Lys Lys Leu His Lys Gln Ile Leu Cys Lys Lys 
        275                 280                 285             


Ser Ser Tyr Tyr Glu Ile Pro Phe Arg Phe Glu Ser Asp Gln Glu Val 
    290                 295                 300                 


Tyr Asp Ala Leu Asn Glu Phe Ile Lys Thr Met Lys Lys Lys Glu Ile 
305                 310                 315                 320 


Ile Arg Arg Cys Val His Leu Gly Gln Glu Cys Asp Asp Tyr Asp Leu 
                325                 330                 335     


Gly Lys Ile Tyr Ile Ser Ser Asn Lys Tyr Glu Gln Ile Ser Asn Ala 
            340                 345                 350         


Leu Tyr Gly Ser Trp Asp Thr Ile Arg Lys Cys Ile Lys Glu Glu Tyr 
        355                 360                 365             


Met Asp Ala Leu Pro Gly Lys Gly Glu Lys Lys Glu Glu Lys Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Lys Glu Glu Tyr Arg Ser Ile Ala Asp Ile Asp Lys 
385                 390                 395                 400 


Ile Ile Ser Leu Tyr Gly Ser Glu Met Asp Arg Thr Ile Ser Ala Lys 
                405                 410                 415     


Lys Cys Ile Thr Glu Ile Cys Asp Met Ala Gly Gln Ile Ser Ile Asp 
            420                 425                 430         


Pro Leu Val Cys Asn Ser Asp Ile Lys Leu Leu Gln Asn Lys Glu Lys 
        435                 440                 445             


Thr Thr Glu Ile Lys Thr Ile Leu Asp Ser Phe Leu His Val Tyr Gln 
    450                 455                 460                 


Trp Gly Gln Thr Phe Ile Val Ser Asp Ile Ile Glu Lys Asp Ser Tyr 
465                 470                 475                 480 


Phe Tyr Ser Glu Leu Glu Asp Val Leu Glu Asp Phe Glu Gly Ile Thr 
                485                 490                 495     


Thr Leu Tyr Asn His Val Arg Ser Tyr Val Thr Gln Lys Pro Tyr Ser 
            500                 505                 510         


Thr Val Lys Phe Lys Leu His Phe Gly Ser Pro Thr Leu Ala Asn Gly 
        515                 520                 525             


Trp Ser Gln Ser Lys Glu Tyr Asp Asn Asn Ala Ile Leu Leu Met Arg 
    530                 535                 540                 


Asp Gln Lys Phe Tyr Leu Gly Ile Phe Asn Val Arg Asn Lys Pro Asp 
545                 550                 555                 560 


Lys Gln Ile Ile Lys Gly His Glu Lys Glu Glu Lys Gly Asp Tyr Lys 
                565                 570                 575     


Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Ser Lys Met Leu Pro Lys 
            580                 585                 590         


Val Phe Ile Thr Ser Arg Ser Gly Gln Glu Thr Tyr Lys Pro Ser Lys 
        595                 600                 605             


His Ile Leu Asp Gly Tyr Asn Glu Lys Arg His Ile Lys Ser Ser Pro 
    610                 615                 620                 


Lys Phe Asp Leu Gly Tyr Cys Trp Asp Leu Ile Asp Tyr Tyr Lys Glu 
625                 630                 635                 640 


Cys Ile His Lys His Pro Asp Trp Lys Asn Tyr Asp Phe His Phe Ser 
                645                 650                 655     


Asp Thr Lys Asp Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu 
            660                 665                 670         


Met Gln Gly Tyr Gln Ile Lys Trp Thr Tyr Ile Ser Ala Asp Glu Ile 
        675                 680                 685             


Gln Lys Leu Asp Glu Lys Gly Gln Ile Phe Leu Phe Gln Ile Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Val His Ser Thr Gly Lys Asp Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile Val Leu 
                725                 730                 735     


Lys Leu Asn Gly Glu Ala Glu Leu Phe Phe Arg Lys Ala Ser Ile Lys 
            740                 745                 750         


Thr Pro Ile Val His Lys Lys Gly Ser Val Leu Val Asn Arg Ser Tyr 
        755                 760                 765             


Thr Gln Thr Val Gly Asn Lys Glu Ile Arg Val Ser Ile Pro Glu Glu 
    770                 775                 780                 


Tyr Tyr Thr Glu Ile Tyr Asn Tyr Leu Asn His Ile Gly Lys Gly Lys 
785                 790                 795                 800 


Leu Ser Ser Glu Ala Gln Arg Tyr Leu Asp Glu Gly Lys Ile Lys Ser 
                805                 810                 815     


Phe Thr Ala Thr Lys Asp Ile Val Lys Asn Tyr Arg Tyr Cys Cys Asp 
            820                 825                 830         


His Tyr Phe Leu His Leu Pro Ile Thr Ile Asn Phe Lys Ala Lys Ser 
        835                 840                 845             


Asp Val Ala Val Asn Glu Arg Thr Leu Ala Tyr Ile Ala Lys Lys Glu 
    850                 855                 860                 


Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr 
865                 870                 875                 880 


Ile Ser Val Val Asp Val His Gly Asn Ile Arg Glu Gln Arg Ser Phe 
                885                 890                 895     


Asn Ile Val Asn Gly Tyr Asp Tyr Gln Gln Lys Leu Lys Asp Arg Glu 
            900                 905                 910         


Lys Ser Arg Asp Ala Ala Arg Lys Asn Trp Glu Glu Ile Glu Lys Ile 
        915                 920                 925             


Lys Glu Leu Lys Glu Gly Tyr Leu Ser Met Val Ile His Tyr Ile Ala 
    930                 935                 940                 


Gln Leu Val Val Lys Tyr Asn Ala Val Val Ala Met Glu Asp Leu Asn 
945                 950                 955                 960 


Tyr Gly Phe Lys Thr Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln 
                965                 970                 975     


Lys Phe Glu Thr Met Leu Ile Glu Lys Leu His Tyr Leu Val Phe Lys 
            980                 985                 990         


Asp Arg Glu Val Cys Glu Glu Gly  Gly Val Leu Arg Gly  Tyr Gln Leu 
        995                 1000                 1005             


Thr Tyr  Ile Pro Glu Ser Leu  Lys Lys Val Gly Lys  Gln Cys Gly 
    1010                 1015                 1020             


Phe Ile  Phe Tyr Val Pro Ala  Gly Tyr Thr Ser Lys  Ile Asp Pro 
    1025                 1030                 1035             


Thr Thr  Gly Phe Val Asn Leu  Phe Ser Phe Lys Asn  Leu Thr Asn 
    1040                 1045                 1050             


Arg Glu  Ser Arg Gln Asp Phe  Val Gly Lys Phe Asp  Glu Ile Arg 
    1055                 1060                 1065             


Tyr Asp  Arg Asp Lys Lys Met  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1070                 1075                 1080             


Asn Tyr  Ile Lys Lys Gly Thr  Ile Leu Ala Ser Thr  Lys Trp Lys 
    1085                 1090                 1095             


Val Tyr  Thr Asn Gly Thr Arg  Leu Lys Arg Ile Val  Val Asn Gly 
    1100                 1105                 1110             


Lys Tyr  Thr Ser Gln Ser Met  Glu Val Glu Leu Thr  Asp Ala Met 
    1115                 1120                 1125             


Glu Lys  Met Leu Gln Arg Ala  Gly Ile Glu Tyr His  Asp Gly Lys 
    1130                 1135                 1140             


Asp Leu  Lys Gly Gln Ile Val  Glu Lys Gly Ile Glu  Ala Glu Ile 
    1145                 1150                 1155             


Ile Asp  Ile Phe Arg Leu Thr  Val Gln Met Arg Asn  Ser Arg Ser 
    1160                 1165                 1170             


Glu Ser  Glu Asp Arg Glu Tyr  Asp Arg Leu Ile Ser  Pro Val Leu 
    1175                 1180                 1185             


Asn Asp  Lys Gly Glu Phe Phe  Asp Thr Ala Thr Ala  Asp Lys Thr 
    1190                 1195                 1200             


Leu Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr Cys  Ile Ala Leu 
    1205                 1210                 1215             


Lys Gly  Leu Tyr Glu Val Lys  Gln Ile Lys Glu Asn  Trp Lys Glu 
    1220                 1225                 1230             


Asn Glu  Gln Phe Pro Arg Asn  Lys Leu Val Gln Asp  Asn Lys Thr 
    1235                 1240                 1245             


Trp Phe  Asp Phe Met Gln Lys  Lys Arg Tyr Leu 
    1250                 1255                 


<210>  54
<211>  1306
<212>  PRT
<213>  Prevotella copri

<400>  54

Met Ala Lys Asn Phe Glu Asp Phe Lys Arg Leu Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Ala Lys Pro Ile Gly Ala Thr Leu Asp Asn Ile 
            20                  25                  30          


Val Lys Ser Gly Leu Leu Asp Glu Asp Glu His Arg Ala Ala Ser Tyr 
        35                  40                  45              


Val Lys Val Lys Lys Leu Ile Asp Glu Tyr His Lys Val Phe Ile Asp 
    50                  55                  60                  


Arg Val Leu Asp Asp Gly Cys Leu Pro Leu Glu Asn Lys Gly Asn Asn 
65                  70                  75                  80  


Asn Ser Leu Ala Glu Tyr Tyr Glu Ser Tyr Val Ser Arg Ala Gln Asp 
                85                  90                  95      


Glu Asp Ala Lys Lys Lys Phe Lys Glu Ile Gln Gln Asn Leu Arg Ser 
            100                 105                 110         


Val Ile Ala Lys Lys Leu Thr Glu Asp Lys Ala Tyr Ala Asn Leu Phe 
        115                 120                 125             


Gly Asn Lys Leu Ile Glu Ser Tyr Lys Asp Lys Glu Asp Lys Lys Lys 
    130                 135                 140                 


Ile Ile Asp Ser Asp Leu Ile Gln Phe Ile Asn Thr Ala Glu Ser Thr 
145                 150                 155                 160 


Gln Leu Asp Ser Met Ser Gln Asp Glu Ala Lys Glu Leu Val Lys Glu 
                165                 170                 175     


Phe Trp Gly Phe Val Thr Tyr Phe Tyr Gly Phe Phe Asp Asn Arg Lys 
            180                 185                 190         


Asn Met Tyr Thr Ala Glu Glu Lys Ser Thr Gly Ile Ala Tyr Arg Leu 
        195                 200                 205             


Val Asn Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Glu Ala Phe Asn 
    210                 215                 220                 


Arg Ala Ile Thr Arg Pro Glu Ile Gln Glu Asn Met Gly Val Leu Tyr 
225                 230                 235                 240 


Ser Asp Phe Ser Glu Tyr Leu Asn Val Glu Ser Ile Gln Glu Met Phe 
                245                 250                 255     


Gln Leu Asp Tyr Tyr Asn Met Leu Leu Thr Gln Lys Gln Ile Asp Val 
            260                 265                 270         


Tyr Asn Ala Ile Ile Gly Gly Lys Thr Asp Asp Glu His Asp Val Lys 
        275                 280                 285             


Ile Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Gln His Lys 
    290                 295                 300                 


Asp Asp Lys Leu Pro Lys Leu Lys Ala Leu Phe Lys Gln Ile Leu Ser 
305                 310                 315                 320 


Asp Arg Asn Ala Ile Ser Trp Leu Pro Glu Glu Phe Asn Ser Asp Gln 
                325                 330                 335     


Glu Val Leu Asn Ala Ile Lys Asp Cys Tyr Glu Arg Leu Ala Glu Asn 
            340                 345                 350         


Val Leu Gly Asp Lys Val Leu Lys Ser Leu Leu Gly Ser Leu Ala Asp 
        355                 360                 365             


Tyr Ser Leu Asp Gly Ile Phe Ile Arg Asn Asp Leu Gln Leu Thr Asp 
    370                 375                 380                 


Ile Ser Gln Lys Met Phe Gly Asn Trp Gly Val Ile Gln Asn Ala Ile 
385                 390                 395                 400 


Met Gln Asn Ile Lys Arg Val Ala Pro Ala Arg Lys His Lys Glu Ser 
                405                 410                 415     


Glu Glu Asp Tyr Glu Lys Arg Ile Ala Gly Ile Phe Lys Lys Ala Asp 
            420                 425                 430         


Ser Phe Ser Ile Ser Tyr Ile Asn Asp Cys Leu Asn Glu Ala Asp Pro 
        435                 440                 445             


Asn Asn Ala Tyr Phe Val Glu Asn Tyr Phe Ala Thr Phe Gly Ala Val 
    450                 455                 460                 


Asn Thr Pro Thr Met Gln Arg Glu Asn Leu Phe Ala Leu Val Gln Asn 
465                 470                 475                 480 


Ala Tyr Thr Glu Val Ala Ala Leu Leu His Ser Asp Tyr Pro Thr Val 
                485                 490                 495     


Lys His Leu Ala Gln Asp Lys Ala Asn Val Ser Lys Ile Lys Ala Leu 
            500                 505                 510         


Leu Asp Ala Ile Lys Ser Leu Gln His Phe Val Lys Pro Leu Leu Gly 
        515                 520                 525             


Lys Gly Asp Glu Ser Asp Lys Asp Glu Arg Phe Tyr Gly Glu Leu Ala 
    530                 535                 540                 


Ser Leu Trp Ala Glu Leu Asp Thr Val Thr Pro Leu Tyr Asn Met Ile 
545                 550                 555                 560 


Arg Asn Tyr Met Thr Arg Lys Pro Tyr Ser Gln Lys Lys Ile Lys Leu 
                565                 570                 575     


Asn Phe Glu Asn Pro Gln Leu Leu Gly Gly Trp Asp Ala Asn Lys Glu 
            580                 585                 590         


Lys Asp Tyr Ala Thr Ile Ile Leu Arg Arg Asn Gly Leu Tyr Tyr Leu 
        595                 600                 605             


Ala Ile Met Asp Lys Asp Ser Arg Lys Leu Leu Gly Lys Ala Met Pro 
    610                 615                 620                 


Ser Asp Gly Glu Cys Tyr Glu Lys Met Val Tyr Lys Phe Phe Lys Asp 
625                 630                 635                 640 


Val Thr Thr Met Ile Pro Lys Cys Ser Thr Gln Leu Lys Asp Val Gln 
                645                 650                 655     


Ala Tyr Phe Lys Val Asn Thr Asp Asp Tyr Val Leu Asn Ser Lys Ala 
            660                 665                 670         


Phe Asn Lys Pro Leu Thr Ile Thr Lys Glu Val Phe Asp Leu Asn Asn 
        675                 680                 685             


Val Leu Tyr Gly Lys Tyr Lys Lys Phe Gln Lys Gly Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Gly Asp Asn Val Gly Tyr Thr His Ala Val Asn Val Trp Ile Lys 
705                 710                 715                 720 


Phe Cys Met Asp Phe Leu Asn Ser Tyr Asp Ser Thr Cys Ile Tyr Asp 
                725                 730                 735     


Phe Ser Ser Leu Lys Pro Glu Ser Tyr Leu Ser Leu Asp Ala Phe Tyr 
            740                 745                 750         


Gln Asp Ala Asn Leu Leu Leu Tyr Lys Leu Ser Phe Ala Arg Ala Ser 
        755                 760                 765             


Val Ser Tyr Ile Asn Gln Leu Val Glu Glu Gly Lys Met Tyr Leu Phe 
    770                 775                 780                 


Gln Ile Tyr Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn 
785                 790                 795                 800 


Met His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Ala 
                805                 810                 815     


Asp Val Val Tyr Lys Leu Asn Gly Gln Ala Glu Met Phe Tyr Arg Lys 
            820                 825                 830         


Lys Ser Ile Glu Asn Thr His Pro Thr His Pro Ala Asn His Pro Ile 
        835                 840                 845             


Leu Asn Lys Asn Lys Asp Asn Lys Lys Lys Glu Ser Leu Phe Asp Tyr 
    850                 855                 860                 


Asp Leu Ile Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Met Phe His 
865                 870                 875                 880 


Val Pro Ile Thr Met Asn Phe Lys Ser Val Gly Ser Glu Asn Ile Asn 
                885                 890                 895     


Gln Asp Val Lys Ala Tyr Leu Arg His Ala Asp Asp Met His Ile Ile 
            900                 905                 910         


Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Val Val Ile Asp 
        915                 920                 925             


Leu Gln Gly Asn Ile Lys Glu Gln Tyr Ser Leu Asn Glu Ile Val Asn 
    930                 935                 940                 


Glu Tyr Asn Gly Asn Thr Tyr His Thr Asn Tyr His Asp Leu Leu Asp 
945                 950                 955                 960 


Val Arg Glu Glu Glu Arg Leu Lys Ala Arg Gln Ser Trp Gln Thr Ile 
                965                 970                 975     


Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His 
            980                 985                 990         


Lys Ile Thr Gln Leu Met Val Arg  Tyr His Ala Ile Val  Val Leu Glu 
        995                 1000                 1005             


Asp Leu  Ser Lys Gly Phe Met  Arg Ser Arg Gln Lys  Val Glu Lys 
    1010                 1015                 1020             


Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1025                 1030                 1035             


Tyr Leu  Val Asp Lys Lys Thr  Asp Val Ser Thr Pro  Gly Gly Leu 
    1040                 1045                 1050             


Leu Asn  Ala Tyr Gln Leu Thr  Cys Lys Ser Asp Ser  Ser Gln Lys 
    1055                 1060                 1065             


Leu Gly  Lys Gln Ser Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1070                 1075                 1080             


Thr Ser  Lys Ile Asp Pro Val  Thr Gly Phe Val Asn  Leu Leu Asp 
    1085                 1090                 1095             


Thr His  Ser Leu Asn Ser Lys  Glu Lys Ile Lys Ala  Phe Phe Ser 
    1100                 1105                 1110             


Lys Phe  Asp Ala Ile Arg Tyr  Asn Lys Asp Lys Lys  Trp Phe Glu 
    1115                 1120                 1125             


Phe Asn  Leu Asp Tyr Asp Lys  Phe Gly Lys Lys Ala  Glu Asp Thr 
    1130                 1135                 1140             


Arg Thr  Lys Trp Thr Leu Cys  Thr Arg Gly Met Arg  Ile Asp Thr 
    1145                 1150                 1155             


Phe Arg  Asn Lys Glu Lys Asn  Ser Gln Trp Asp Asn  Gln Glu Val 
    1160                 1165                 1170             


Asp Leu  Thr Thr Glu Met Lys  Ser Leu Leu Glu His  Tyr Tyr Ile 
    1175                 1180                 1185             


Asp Ile  His Gly Asn Leu Lys  Asp Ala Ile Ser Ala  Gln Thr Asp 
    1190                 1195                 1200             


Lys Ala  Phe Phe Thr Gly Leu  Leu His Ile Leu Lys  Leu Thr Leu 
    1205                 1210                 1215             


Gln Met  Arg Asn Ser Ile Thr  Gly Thr Glu Thr Asp  Tyr Leu Val 
    1220                 1225                 1230             


Ser Pro  Val Ala Asp Glu Asn  Gly Ile Phe Tyr Asp  Ser Arg Ser 
    1235                 1240                 1245             


Cys Gly  Asn Gln Leu Pro Glu  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1250                 1255                 1260             


Asn Ile  Ala Arg Lys Gly Leu  Met Leu Ile Glu Gln  Ile Lys Asn 
    1265                 1270                 1275             


Ala Glu  Asp Leu Asn Asn Val  Lys Phe Asp Ile Ser  Asn Lys Ala 
    1280                 1285                 1290             


Trp Leu  Asn Phe Ala Gln Gln  Lys Pro Tyr Lys Asn  Gly 
    1295                 1300                 1305     


<210>  55
<211>  1142
<212>  PRT
<213>  Eubacterium rectale

<400>  55

Met Phe Ser Ala Lys Leu Ile Ser Asp Ile Leu Pro Glu Phe Val Ile 
1               5                   10                  15      


His Asn Asn Asn Tyr Ser Ala Ser Glu Lys Glu Glu Lys Thr Gln Val 
            20                  25                  30          


Ile Lys Leu Phe Ser Arg Phe Ala Thr Ser Phe Lys Asp Tyr Phe Lys 
        35                  40                  45              


Asn Arg Ala Asn Cys Phe Ser Ala Asn Asp Ile Ser Ser Ser Ser Cys 
    50                  55                  60                  


His Arg Ile Val Asn Asp Asn Ala Glu Ile Phe Phe Ser Asn Ala Leu 
65                  70                  75                  80  


Val Tyr Arg Arg Ile Val Lys Asn Leu Ser Asn Asp Asp Ile Asn Lys 
                85                  90                  95      


Ile Ser Gly Asp Met Lys Asp Ser Leu Lys Glu Met Ser Leu Glu Glu 
            100                 105                 110         


Ile Tyr Ser Tyr Glu Lys Tyr Gly Glu Phe Ile Thr Gln Glu Gly Ile 
        115                 120                 125             


Ser Phe Tyr Asn Asp Ile Cys Gly Lys Val Asn Leu Phe Met Asn Leu 
    130                 135                 140                 


Tyr Cys Gln Lys Asn Lys Glu Asn Lys Asn Leu Tyr Lys Leu Arg Lys 
145                 150                 155                 160 


Leu His Lys Gln Ile Leu Cys Ile Ala Asp Thr Ser Tyr Glu Val Pro 
                165                 170                 175     


Tyr Lys Phe Glu Ser Asp Glu Glu Val Tyr Gln Ser Val Asn Gly Phe 
            180                 185                 190         


Leu Asp Asn Ile Ser Ser Lys His Ile Val Glu Arg Leu Arg Lys Ile 
        195                 200                 205             


Gly Glu Asn Tyr Asn Gly Tyr Asn Leu Asp Lys Ile Tyr Ile Val Ser 
    210                 215                 220                 


Lys Phe Tyr Glu Ser Val Ser Gln Lys Thr Tyr Arg Asp Trp Glu Thr 
225                 230                 235                 240 


Ile Asn Thr Ala Leu Glu Ile His Tyr Asn Asn Ile Leu Pro Gly Asn 
                245                 250                 255     


Gly Lys Ser Lys Ala Asp Lys Val Lys Lys Ala Val Lys Asn Asp Leu 
            260                 265                 270         


Gln Lys Ser Ile Thr Glu Ile Asn Glu Leu Val Ser Asn Tyr Lys Leu 
        275                 280                 285             


Cys Pro Asp Asp Asn Ile Lys Ala Glu Thr Tyr Ile His Glu Ile Ser 
    290                 295                 300                 


His Ile Leu Asn Asn Phe Glu Ala Gln Glu Leu Lys Tyr Asn Pro Glu 
305                 310                 315                 320 


Ile His Leu Val Glu Ser Glu Leu Lys Ala Ser Glu Leu Lys Asn Val 
                325                 330                 335     


Leu Asp Val Ile Met Asn Ala Phe His Trp Cys Ser Val Phe Met Thr 
            340                 345                 350         


Glu Glu Leu Val Asp Lys Asp Asn Asn Phe Tyr Ala Glu Leu Glu Glu 
        355                 360                 365             


Ile Tyr Asp Glu Ile Tyr Pro Val Ile Ser Leu Tyr Asn Leu Val Arg 
    370                 375                 380                 


Asn Tyr Val Thr Gln Lys Pro Tyr Ser Thr Lys Lys Ile Lys Leu Asn 
385                 390                 395                 400 


Phe Gly Ile Pro Thr Leu Ala Asp Gly Trp Ser Lys Ser Lys Glu Tyr 
                405                 410                 415     


Ser Asn Asn Ala Ile Ile Leu Met Arg Asp Asn Leu Tyr Tyr Leu Gly 
            420                 425                 430         


Ile Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Glu Gly Asn 
        435                 440                 445             


Thr Ser Glu Asn Lys Gly Asp Tyr Lys Lys Met Ile Tyr Asn Leu Leu 
    450                 455                 460                 


Pro Gly Pro Asn Lys Met Ile Pro Lys Val Phe Leu Ser Ser Lys Thr 
465                 470                 475                 480 


Gly Val Glu Thr Tyr Lys Pro Ser Ala Tyr Ile Leu Glu Gly Tyr Lys 
                485                 490                 495     


Gln Asn Lys His Leu Lys Ser Ser Lys Asp Phe Asp Ile Thr Phe Cys 
            500                 505                 510         


His Asp Leu Ile Asp Tyr Phe Lys Asn Cys Ile Ala Ile His Pro Glu 
        515                 520                 525             


Trp Lys Asn Phe Gly Phe Asp Phe Ser Asp Thr Ser Thr Tyr Glu Asp 
    530                 535                 540                 


Ile Ser Gly Phe Tyr Arg Glu Val Glu Leu Gln Gly Tyr Lys Ile Asp 
545                 550                 555                 560 


Trp Thr Tyr Ile Ser Glu Lys Asp Ile Asp Leu Leu Gln Glu Lys Gly 
                565                 570                 575     


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Lys Lys Ser 
            580                 585                 590         


Ser Gly Asn Asp Asn Leu His Thr Met Tyr Leu Lys Asn Leu Phe Ser 
        595                 600                 605             


Glu Glu Asn Leu Lys Asp Ile Val Leu Lys Leu Asn Gly Glu Ala Glu 
    610                 615                 620                 


Ile Phe Phe Arg Lys Ser Ser Ile Lys Asn Pro Ile Ile His Lys Lys 
625                 630                 635                 640 


Gly Ser Ile Leu Val Asn Arg Thr Tyr Glu Ala Glu Glu Lys Asp Gln 
                645                 650                 655     


Phe Gly Asn Ile Gln Ile Val Arg Lys Thr Ile Pro Glu Asn Ile Tyr 
            660                 665                 670         


Gln Glu Leu Tyr Lys Tyr Phe Asn Asp Lys Ser Asp Lys Glu Leu Ser 
        675                 680                 685             


Asp Glu Ala Ala Lys Leu Lys Asn Val Val Gly His His Glu Ala Ala 
    690                 695                 700                 


Thr Asn Ile Val Lys Asp Tyr Arg Tyr Thr Tyr Asp Lys Tyr Phe Leu 
705                 710                 715                 720 


His Met Pro Ile Thr Ile Asn Phe Lys Ala Asn Lys Thr Ser Phe Ile 
                725                 730                 735     


Asn Asp Arg Ile Leu Gln Tyr Ile Ala Lys Glu Lys Asp Leu His Val 
            740                 745                 750         


Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Val Ser Val Ile 
        755                 760                 765             


Asp Thr Cys Gly Asn Ile Val Glu Gln Lys Ser Phe Asn Ile Val Asn 
    770                 775                 780                 


Gly Tyr Asp Tyr Gln Ile Lys Leu Lys Gln Gln Glu Gly Ala Arg Gln 
785                 790                 795                 800 


Ile Ala Arg Lys Glu Trp Lys Glu Ile Gly Lys Ile Lys Glu Ile Lys 
                805                 810                 815     


Glu Gly Tyr Leu Ser Leu Val Ile His Glu Ile Ser Lys Met Val Ile 
            820                 825                 830         


Lys Tyr Asn Ala Ile Ile Ala Met Glu Asp Leu Ser Tyr Gly Phe Lys 
        835                 840                 845             


Lys Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Thr 
    850                 855                 860                 


Met Leu Ile Asn Lys Leu Asn Tyr Leu Val Phe Lys Asp Ile Ser Ile 
865                 870                 875                 880 


Thr Glu Asn Gly Gly Leu Leu Lys Gly Tyr Gln Leu Thr Tyr Ile Pro 
                885                 890                 895     


Asp Lys Leu Lys Asn Val Gly His Gln Cys Gly Cys Ile Phe Tyr Val 
            900                 905                 910         


Pro Ala Ala Tyr Thr Ser Lys Ile Asp Pro Thr Thr Gly Phe Val Asn 
        915                 920                 925             


Ile Phe Lys Phe Lys Asp Leu Thr Val Asp Ala Lys Arg Glu Phe Ile 
    930                 935                 940                 


Lys Lys Phe Asp Ser Ile Arg Tyr Asp Ser Asp Lys Asn Leu Phe Cys 
945                 950                 955                 960 


Phe Thr Phe Asp Tyr Asn Asn Phe Ile Thr Gln Asn Thr Val Met Ser 
                965                 970                 975     


Lys Ser Ser Trp Ser Val Tyr Thr Tyr Gly Val Arg Ile Lys Arg Arg 
            980                 985                 990         


Phe Val Asn Gly Arg Phe Ser Asn  Glu Ser Asp Thr Ile  Asp Ile Thr 
        995                 1000                 1005             


Lys Asp  Met Glu Lys Thr Leu  Glu Met Thr Asp Ile  Asn Trp Arg 
    1010                 1015                 1020             


Asp Gly  His Asp Leu Arg Gln  Asp Ile Ile Asp Tyr  Glu Ile Val 
    1025                 1030                 1035             


Gln His  Ile Phe Glu Ile Phe  Lys Leu Thr Val Gln  Met Arg Asn 
    1040                 1045                 1050             


Ser Leu  Ser Glu Leu Glu Asp  Arg Asp Tyr Asp Arg  Leu Ile Ser 
    1055                 1060                 1065             


Pro Val  Leu Asn Glu Asn Asn  Ile Phe Tyr Asp Ser  Ala Lys Ala 
    1070                 1075                 1080             


Gly Asp  Ala Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Ile Ala  Leu Lys Gly Leu Tyr  Glu Ile Lys Gln Ile  Thr Glu Asn 
    1100                 1105                 1110             


Trp Lys  Glu Asp Gly Lys Phe  Ser Arg Asp Lys Leu  Lys Ile Ser 
    1115                 1120                 1125             


Asn Lys  Asp Trp Phe Asp Phe  Ile Gln Asn Lys Arg  Tyr Leu 
    1130                 1135                 1140         


<210>  56
<211>  1259
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  56

Met Asn Tyr Lys Thr Gly Leu Glu Asp Phe Ile Gly Lys Glu Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Ser Thr Lys Ile 
            20                  25                  30          


His Met Glu Glu Met Gly Val Ile Arg Asp Asp Glu Leu Arg Ala Glu 
        35                  40                  45              


Lys Gln Gln Glu Leu Lys Glu Ile Met Asp Asp Tyr Tyr Arg Ala Phe 
    50                  55                  60                  


Ile Glu Glu Lys Leu Gly Gln Ile Gln Gly Ile Gln Trp Asn Ser Leu 
65                  70                  75                  80  


Phe Gln Lys Met Glu Glu Thr Met Glu Asp Ile Ser Val Arg Lys Asp 
                85                  90                  95      


Leu Asp Lys Ile Gln Asn Glu Lys Arg Lys Glu Ile Cys Cys Tyr Phe 
            100                 105                 110         


Thr Ser Asp Lys Arg Phe Lys Asp Leu Phe Asn Ala Lys Leu Ile Thr 
        115                 120                 125             


Asp Ile Leu Pro Asn Phe Ile Lys Asp Asn Lys Glu Tyr Thr Glu Glu 
    130                 135                 140                 


Glu Lys Ala Glu Lys Glu Gln Thr Arg Val Leu Phe Gln Arg Phe Ala 
145                 150                 155                 160 


Thr Ala Phe Thr Asn Tyr Phe Asn Gln Arg Arg Asn Asn Phe Ser Glu 
                165                 170                 175     


Asp Asn Ile Ser Thr Ala Ile Ser Phe Arg Ile Val Asn Glu Asn Ser 
            180                 185                 190         


Glu Ile His Leu Gln Asn Met Arg Ala Phe Gln Arg Ile Glu Gln Gln 
        195                 200                 205             


Tyr Pro Glu Glu Val Cys Gly Met Glu Glu Glu Tyr Lys Asp Met Leu 
    210                 215                 220                 


Gln Glu Trp Gln Met Lys His Ile Tyr Leu Val Asp Phe Tyr Asp Arg 
225                 230                 235                 240 


Val Leu Thr Gln Pro Gly Ile Glu Tyr Tyr Asn Gly Ile Cys Gly Lys 
                245                 250                 255     


Ile Asn Glu His Met Asn Gln Phe Cys Gln Lys Asn Arg Ile Asn Lys 
            260                 265                 270         


Asn Asp Phe Arg Met Lys Lys Leu His Lys Gln Ile Leu Cys Lys Lys 
        275                 280                 285             


Ser Ser Tyr Tyr Glu Ile Pro Phe Arg Phe Glu Ser Asp Gln Glu Val 
    290                 295                 300                 


Tyr Asp Ala Leu Asn Glu Phe Ile Lys Thr Met Lys Glu Lys Glu Ile 
305                 310                 315                 320 


Ile Cys Arg Cys Val His Leu Gly Gln Lys Cys Asp Asp Tyr Asp Leu 
                325                 330                 335     


Gly Lys Ile Tyr Ile Ser Ser Asn Lys Tyr Glu Gln Ile Ser Asn Ala 
            340                 345                 350         


Leu Tyr Gly Ser Trp Asp Thr Ile Arg Lys Cys Ile Lys Glu Glu Tyr 
        355                 360                 365             


Met Asp Ala Leu Pro Gly Lys Gly Glu Lys Lys Glu Glu Lys Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Lys Glu Glu Tyr Arg Ser Ile Ala Asp Ile Asp Lys 
385                 390                 395                 400 


Ile Ile Ser Leu Tyr Gly Ser Glu Met Asp Arg Thr Ile Ser Ala Lys 
                405                 410                 415     


Lys Cys Ile Thr Glu Ile Cys Asp Met Ala Gly Gln Ile Ser Thr Asp 
            420                 425                 430         


Pro Leu Val Cys Asn Ser Asp Ile Lys Leu Leu Gln Asn Lys Glu Lys 
        435                 440                 445             


Thr Thr Glu Ile Lys Thr Ile Leu Asp Ser Phe Leu His Val Tyr Gln 
    450                 455                 460                 


Trp Gly Gln Thr Phe Ile Val Ser Asp Ile Ile Glu Lys Asp Ser Tyr 
465                 470                 475                 480 


Phe Tyr Ser Glu Leu Glu Asp Val Leu Glu Asp Phe Glu Gly Ile Thr 
                485                 490                 495     


Thr Leu Tyr Asn His Val Arg Ser Tyr Val Thr Gln Lys Pro Tyr Ser 
            500                 505                 510         


Thr Val Lys Phe Lys Leu His Phe Gly Ser Pro Thr Leu Ala Asn Gly 
        515                 520                 525             


Trp Ser Gln Ser Lys Glu Tyr Asp Asn Asn Ala Ile Leu Leu Met Arg 
    530                 535                 540                 


Asp Gln Lys Phe Tyr Leu Gly Ile Phe Asn Val Arg Asn Lys Pro Asp 
545                 550                 555                 560 


Lys Gln Ile Ile Lys Gly His Glu Lys Glu Glu Lys Gly Asp Tyr Lys 
                565                 570                 575     


Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Ser Lys Met Leu Pro Lys 
            580                 585                 590         


Val Phe Ile Thr Ser Arg Ser Gly Gln Glu Thr Tyr Lys Pro Ser Lys 
        595                 600                 605             


His Ile Leu Asp Gly Tyr Asn Glu Lys Arg His Ile Lys Ser Ser Pro 
    610                 615                 620                 


Lys Phe Asp Leu Gly Tyr Cys Trp Asp Leu Ile Asp Tyr Tyr Lys Glu 
625                 630                 635                 640 


Cys Ile His Lys His Pro Asp Trp Lys Asn Tyr Asp Phe His Phe Ser 
                645                 650                 655     


Asp Thr Lys Asp Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu 
            660                 665                 670         


Met Gln Gly Tyr Gln Ile Lys Trp Thr Tyr Ile Ser Ala Asp Glu Ile 
        675                 680                 685             


Gln Lys Leu Asp Glu Lys Gly Gln Ile Phe Leu Phe Gln Ile Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Val His Ser Thr Gly Lys Asp Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile Val Leu 
                725                 730                 735     


Lys Leu Asn Gly Glu Ala Glu Leu Phe Phe Arg Lys Ala Ser Ile Lys 
            740                 745                 750         


Thr Pro Val Val His Lys Lys Gly Ser Val Leu Val Asn Arg Ser Tyr 
        755                 760                 765             


Thr Gln Thr Val Gly Asp Lys Glu Ile Arg Val Ser Ile Pro Glu Glu 
    770                 775                 780                 


Tyr Tyr Thr Glu Ile Tyr Asn Tyr Leu Asn His Ile Gly Arg Gly Lys 
785                 790                 795                 800 


Leu Ser Thr Glu Ala Gln Arg Tyr Leu Glu Glu Arg Lys Ile Lys Ser 
                805                 810                 815     


Phe Thr Ala Thr Lys Asp Ile Val Lys Asn Tyr Arg Tyr Cys Cys Asp 
            820                 825                 830         


His Tyr Phe Leu His Leu Pro Ile Thr Ile Asn Phe Lys Ala Lys Ser 
        835                 840                 845             


Asp Ile Ala Val Asn Glu Arg Thr Leu Ala Tyr Ile Ala Lys Lys Glu 
    850                 855                 860                 


Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr 
865                 870                 875                 880 


Ile Ser Val Val Asp Val His Gly Asn Ile Arg Glu Gln Arg Ser Phe 
                885                 890                 895     


Asn Ile Val Asn Gly Tyr Asp Tyr Gln Gln Lys Leu Lys Asp Arg Glu 
            900                 905                 910         


Lys Ser Arg Asp Ala Ala Arg Lys Asn Trp Glu Glu Ile Glu Lys Ile 
        915                 920                 925             


Lys Glu Leu Lys Glu Gly Tyr Leu Ser Met Val Ile His Tyr Ile Ala 
    930                 935                 940                 


Gln Leu Val Val Lys Tyr Asn Ala Val Val Ala Met Glu Asp Leu Asn 
945                 950                 955                 960 


Tyr Gly Phe Lys Thr Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln 
                965                 970                 975     


Lys Phe Glu Thr Met Leu Ile Glu Lys Leu His Tyr Leu Val Phe Lys 
            980                 985                 990         


Asp Arg Glu Val Cys Glu Glu Gly  Gly Val Leu Arg Gly  Tyr Gln Leu 
        995                 1000                 1005             


Thr Tyr  Ile Pro Glu Ser Leu  Lys Lys Val Gly Lys  Gln Cys Gly 
    1010                 1015                 1020             


Phe Ile  Phe Tyr Val Pro Ala  Gly Tyr Thr Ser Lys  Ile Asp Pro 
    1025                 1030                 1035             


Thr Thr  Gly Phe Val Asn Leu  Phe Ser Phe Lys Asn  Leu Thr Asn 
    1040                 1045                 1050             


Arg Glu  Ser Arg Gln Asp Phe  Val Gly Lys Phe Asp  Glu Ile Arg 
    1055                 1060                 1065             


Tyr Asp  Arg Asp Lys Lys Met  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1070                 1075                 1080             


Asn Tyr  Ile Lys Lys Gly Thr  Met Leu Ala Ser Thr  Lys Trp Lys 
    1085                 1090                 1095             


Val Tyr  Thr Asn Gly Thr Arg  Leu Lys Arg Ile Val  Val Asn Gly 
    1100                 1105                 1110             


Lys Tyr  Thr Ser Gln Ser Met  Glu Val Glu Leu Thr  Asp Ala Met 
    1115                 1120                 1125             


Glu Lys  Met Leu Gln Arg Ala  Gly Ile Glu Tyr His  Asp Gly Lys 
    1130                 1135                 1140             


Asp Leu  Lys Gly Gln Ile Val  Glu Lys Gly Ile Glu  Ala Glu Ile 
    1145                 1150                 1155             


Ile Asp  Ile Phe Arg Leu Thr  Val Gln Met Arg Asn  Ser Arg Ser 
    1160                 1165                 1170             


Glu Ser  Glu Asp Arg Glu Tyr  Asp Arg Leu Ile Ser  Pro Val Leu 
    1175                 1180                 1185             


Asn Asp  Lys Gly Glu Phe Phe  Asp Thr Ala Thr Ala  Asp Lys Thr 
    1190                 1195                 1200             


Leu Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr Cys  Ile Ala Leu 
    1205                 1210                 1215             


Lys Gly  Leu Tyr Glu Val Lys  Gln Ile Lys Glu Asn  Trp Lys Glu 
    1220                 1225                 1230             


Asn Glu  Gln Phe Pro Arg Asn  Lys Leu Val Gln Asp  Asn Lys Thr 
    1235                 1240                 1245             


Trp Phe  Asp Phe Met Gln Lys  Lys Arg Tyr Leu 
    1250                 1255                 


<210>  57
<211>  1108
<212>  PRT
<213>  Bacillus hisashii

<400>  57

Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Glu Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Tyr Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu Tyr Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Leu Lys Ala Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Val Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Cys Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Val Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210>  58
<211>  1465
<212>  PRT
<213>  Thermomonas hydrothermalis

<400>  58

Met Ser Glu Lys Thr Thr Gln Arg Ala Tyr Thr Leu Arg Leu Asn Arg 
1               5                   10                  15      


Ala Ser Gly Glu Cys Ala Val Cys Gln Asn Asn Ser Cys Asp Cys Trp 
            20                  25                  30          


His Asp Ala Leu Trp Ala Thr His Lys Ala Val Asn Arg Gly Ala Lys 
        35                  40                  45              


Ala Phe Gly Asp Trp Leu Leu Thr Leu Arg Gly Gly Leu Cys His Thr 
    50                  55                  60                  


Leu Val Glu Met Glu Val Pro Ala Lys Gly Asn Asn Pro Pro Gln Arg 
65                  70                  75                  80  


Pro Thr Asp Gln Glu Arg Arg Asp Arg Arg Val Leu Leu Ala Leu Ser 
                85                  90                  95      


Trp Leu Ser Val Glu Asp Glu His Gly Ala Pro Lys Glu Phe Ile Val 
            100                 105                 110         


Ala Thr Gly Arg Asp Ser Ala Asp Asp Arg Ala Lys Lys Val Glu Glu 
        115                 120                 125             


Lys Leu Arg Glu Ile Leu Glu Lys Arg Asp Phe Gln Glu His Glu Ile 
    130                 135                 140                 


Asp Ala Trp Leu Gln Asp Cys Gly Pro Ser Leu Lys Ala His Ile Arg 
145                 150                 155                 160 


Glu Asp Ala Val Trp Val Asn Arg Arg Ala Leu Phe Asp Ala Ala Val 
                165                 170                 175     


Glu Arg Ile Lys Thr Leu Thr Trp Glu Glu Ala Trp Asp Phe Leu Glu 
            180                 185                 190         


Pro Phe Phe Gly Thr Gln Tyr Phe Ala Gly Ile Gly Asp Gly Lys Asp 
        195                 200                 205             


Lys Asp Asp Ala Glu Gly Pro Ala Arg Gln Gly Glu Lys Ala Lys Asp 
    210                 215                 220                 


Leu Val Gln Lys Ala Gly Gln Trp Leu Ser Ala Arg Phe Gly Ile Gly 
225                 230                 235                 240 


Thr Gly Ala Asp Phe Met Ser Met Ala Glu Ala Tyr Glu Lys Ile Ala 
                245                 250                 255     


Lys Trp Ala Ser Gln Ala Gln Asn Gly Asp Asn Gly Lys Ala Thr Ile 
            260                 265                 270         


Glu Lys Leu Ala Cys Ala Leu Arg Pro Ser Glu Pro Pro Thr Leu Asp 
        275                 280                 285             


Thr Val Leu Lys Cys Ile Ser Gly Pro Gly His Lys Ser Ala Thr Arg 
    290                 295                 300                 


Glu Tyr Leu Lys Thr Leu Asp Lys Lys Ser Thr Val Thr Gln Glu Asp 
305                 310                 315                 320 


Leu Asn Gln Leu Arg Lys Leu Ala Asp Glu Asp Ala Arg Asn Cys Arg 
                325                 330                 335     


Lys Lys Val Gly Lys Lys Gly Lys Lys Pro Trp Ala Asp Glu Val Leu 
            340                 345                 350         


Lys Asp Val Glu Asn Ser Cys Glu Leu Thr Tyr Leu Gln Asp Asn Ser 
        355                 360                 365             


Pro Ala Arg His Arg Glu Phe Ser Val Met Leu Asp His Ala Ala Arg 
    370                 375                 380                 


Arg Val Ser Met Ala His Ser Trp Ile Lys Lys Ala Glu Gln Arg Arg 
385                 390                 395                 400 


Arg Gln Phe Glu Ser Asp Ala Gln Lys Leu Lys Asn Leu Gln Glu Arg 
                405                 410                 415     


Ala Pro Ser Ala Val Glu Trp Leu Asp Arg Phe Cys Glu Ser Arg Ser 
            420                 425                 430         


Met Thr Thr Gly Ala Asn Thr Gly Ser Gly Tyr Arg Ile Arg Lys Arg 
        435                 440                 445             


Ala Ile Glu Gly Trp Ser Tyr Val Val Gln Ala Trp Ala Glu Ala Ser 
    450                 455                 460                 


Cys Asp Thr Glu Asp Lys Arg Ile Ala Ala Ala Arg Lys Val Gln Ala 
465                 470                 475                 480 


Asp Pro Glu Ile Glu Lys Phe Gly Asp Ile Gln Leu Phe Glu Ala Leu 
                485                 490                 495     


Ala Ala Asp Glu Ala Ile Cys Val Trp Arg Asp Gln Glu Gly Thr Gln 
            500                 505                 510         


Asn Pro Ser Ile Leu Ile Asp Tyr Val Thr Gly Lys Thr Ala Glu His 
        515                 520                 525             


Asn Gln Lys Arg Phe Lys Val Pro Ala Tyr Arg His Pro Asp Glu Leu 
    530                 535                 540                 


Arg His Pro Val Phe Cys Asp Phe Gly Asn Ser Arg Trp Ser Ile Gln 
545                 550                 555                 560 


Phe Ala Ile His Lys Glu Ile Arg Asp Arg Asp Lys Gly Ala Lys Gln 
                565                 570                 575     


Asp Thr Arg Gln Leu Gln Asn Arg His Gly Leu Lys Met Arg Leu Trp 
            580                 585                 590         


Asn Gly Arg Ser Met Thr Asp Val Asn Leu His Trp Ser Ser Lys Arg 
        595                 600                 605             


Leu Thr Ala Asp Leu Ala Leu Asp Gln Asn Pro Asn Pro Asn Pro Thr 
    610                 615                 620                 


Glu Val Thr Arg Ala Asp Arg Leu Gly Arg Ala Ala Ser Ser Ala Phe 
625                 630                 635                 640 


Asp His Val Lys Ile Lys Asn Val Phe Asn Glu Lys Glu Trp Asn Gly 
                645                 650                 655     


Arg Leu Gln Ala Pro Arg Ala Glu Leu Asp Arg Ile Ala Lys Leu Glu 
            660                 665                 670         


Glu Gln Gly Lys Thr Glu Gln Ala Glu Lys Leu Arg Lys Arg Leu Arg 
        675                 680                 685             


Trp Tyr Val Ser Phe Ser Pro Cys Leu Ser Pro Ser Gly Pro Phe Ile 
    690                 695                 700                 


Val Tyr Ala Gly Gln His Asn Ile Gln Pro Lys Arg Ser Gly Gln Tyr 
705                 710                 715                 720 


Ala Pro His Ala Gln Ala Asn Lys Gly Arg Ala Arg Leu Ala Gln Leu 
                725                 730                 735     


Ile Leu Ser Arg Leu Pro Asp Leu Arg Ile Leu Ser Val Asp Leu Gly 
            740                 745                 750         


His Arg Phe Ala Ala Ala Cys Ala Val Trp Glu Thr Leu Ser Ser Asp 
        755                 760                 765             


Ala Phe Arg Arg Glu Ile Gln Gly Leu Asn Val Leu Ala Gly Gly Ser 
    770                 775                 780                 


Gly Glu Gly Asp Leu Phe Leu His Val Glu Met Thr Gly Asp Asp Gly 
785                 790                 795                 800 


Lys Arg Arg Thr Val Val Tyr Arg Arg Ile Gly Pro Asp Gln Leu Leu 
                805                 810                 815     


Asp Asn Thr Pro His Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln Phe 
            820                 825                 830         


Leu Ile Lys Leu Gln Gly Glu Asp Glu Gly Val Arg Glu Ala Ser Asn 
        835                 840                 845             


Glu Glu Leu Trp Thr Val His Lys Leu Glu Val Glu Val Gly Arg Thr 
    850                 855                 860                 


Val Pro Leu Ile Asp Arg Met Val Arg Ser Gly Phe Gly Lys Thr Glu 
865                 870                 875                 880 


Lys Gln Lys Glu Arg Leu Lys Lys Leu Arg Glu Leu Gly Trp Ile Ser 
                885                 890                 895     


Ala Met Pro Asn Glu Pro Ser Ala Glu Thr Asp Glu Lys Glu Gly Glu 
            900                 905                 910         


Ile Arg Ser Ile Ser Arg Ser Val Asp Glu Leu Met Ser Ser Ala Leu 
        915                 920                 925             


Gly Thr Leu Arg Leu Ala Leu Lys Arg His Gly Asn Arg Ala Arg Ile 
    930                 935                 940                 


Ala Phe Ala Met Thr Ala Asp Tyr Lys Pro Met Pro Gly Gly Gln Lys 
945                 950                 955                 960 


Tyr Tyr Phe His Glu Ala Lys Glu Ala Ser Lys Asn Asp Asp Glu Thr 
                965                 970                 975     


Lys Arg Arg Asp Asn Gln Ile Glu Phe Leu Gln Asp Ala Leu Ser Leu 
            980                 985                 990         


Trp His Asp Leu Phe Ser Ser Pro  Asp Trp Glu Asp Asn  Glu Ala Lys 
        995                 1000                 1005             


Lys Leu  Trp Gln Asn His Ile  Ala Thr Leu Pro Asn  Tyr Gln Thr 
    1010                 1015                 1020             


Pro Glu  Glu Ile Ser Ala Glu  Leu Lys Arg Val Glu  Arg Asn Lys 
    1025                 1030                 1035             


Lys Arg  Lys Glu Asn Arg Asp  Lys Leu Arg Thr Ala  Ala Lys Ala 
    1040                 1045                 1050             


Leu Ala  Glu Asn Asp Gln Leu  Arg Gln His Leu His  Asp Thr Trp 
    1055                 1060                 1065             


Lys Glu  Arg Trp Glu Ser Asp  Asp Gln Gln Trp Lys  Glu Arg Leu 
    1070                 1075                 1080             


Arg Ser  Leu Lys Asp Trp Ile  Phe Pro Arg Gly Lys  Ala Glu Asp 
    1085                 1090                 1095             


Asn Pro  Ser Ile Arg His Val  Gly Gly Leu Ser Ile  Thr Arg Ile 
    1100                 1105                 1110             


Asn Thr  Ile Ser Gly Leu Tyr  Gln Ile Leu Lys Ala  Phe Lys Met 
    1115                 1120                 1125             


Arg Pro  Glu Pro Asp Asp Leu  Arg Lys Asn Ile Pro  Gln Lys Gly 
    1130                 1135                 1140             


Asp Asp  Glu Leu Glu Asn Phe  Asn Arg Arg Leu Leu  Glu Ala Arg 
    1145                 1150                 1155             


Asp Arg  Leu Arg Glu Gln Arg  Val Lys Gln Leu Ala  Ser Arg Ile 
    1160                 1165                 1170             


Ile Glu  Ala Ala Leu Gly Val  Gly Arg Ile Lys Ile  Pro Lys Asn 
    1175                 1180                 1185             


Gly Lys  Leu Pro Lys Arg Pro  Arg Thr Thr Val Asp  Thr Pro Cys 
    1190                 1195                 1200             


His Ala  Val Val Ile Glu Ser  Leu Lys Thr Tyr Arg  Pro Asp Asp 
    1205                 1210                 1215             


Leu Arg  Thr Arg Arg Glu Asn  Arg Gln Leu Met Gln  Trp Ser Ser 
    1220                 1225                 1230             


Ala Lys  Val Arg Lys Tyr Leu  Lys Glu Gly Cys Glu  Leu Tyr Gly 
    1235                 1240                 1245             


Leu His  Phe Leu Glu Val Pro  Ala Asn Tyr Thr Ser  Arg Gln Cys 
    1250                 1255                 1260             


Ser Arg  Thr Gly Leu Pro Gly  Ile Arg Cys Asp Asp  Val Pro Thr 
    1265                 1270                 1275             


Gly Asp  Phe Leu Lys Ala Pro  Trp Trp Arg Arg Ala  Ile Asn Thr 
    1280                 1285                 1290             


Ala Arg  Glu Lys Asn Gly Gly  Asp Ala Lys Asp Arg  Phe Leu Val 
    1295                 1300                 1305             


Asp Leu  Tyr Asp His Leu Asn  Asn Leu Gln Ser Lys  Gly Glu Ala 
    1310                 1315                 1320             


Leu Pro  Ala Thr Val Arg Val  Pro Arg Gln Gly Gly  Asn Leu Phe 
    1325                 1330                 1335             


Ile Ala  Gly Ala Gln Leu Asp  Asp Thr Asn Lys Glu  Arg Arg Ala 
    1340                 1345                 1350             


Ile Gln  Ala Asp Leu Asn Ala  Ala Ala Asn Ile Gly  Leu Arg Ala 
    1355                 1360                 1365             


Leu Leu  Asp Pro Asp Trp Arg  Gly Arg Trp Trp Tyr  Val Pro Cys 
    1370                 1375                 1380             


Lys Asp  Gly Thr Ser Glu Pro  Ala Leu Asp Arg Ile  Glu Gly Ser 
    1385                 1390                 1395             


Thr Ala  Phe Asn Asp Val Arg  Ser Leu Pro Thr Gly  Asp Asn Ser 
    1400                 1405                 1410             


Ser Arg  Arg Ala Pro Arg Glu  Ile Glu Asn Leu Trp  Arg Asp Pro 
    1415                 1420                 1425             


Ser Gly  Asp Ser Leu Glu Ser  Gly Thr Trp Ser Pro  Thr Arg Ala 
    1430                 1435                 1440             


Tyr Trp  Asp Thr Val Gln Ser  Arg Val Ile Glu Leu  Leu Arg Arg 
    1445                 1450                 1455             


His Ala  Gly Leu Pro Thr Ser  
    1460                 1465 


<210>  59
<211>  1090
<212>  PRT
<213>  Laceyella sacchari

<400>  59

Met Ser Ile Arg Ser Phe Lys Leu Lys Leu Lys Thr Lys Ser Gly Val 
1               5                   10                  15      


Asn Ala Glu Gln Leu Arg Arg Gly Leu Trp Arg Thr His Gln Leu Ile 
            20                  25                  30          


Asn Asp Gly Ile Ala Tyr Tyr Met Asn Trp Leu Val Leu Leu Arg Gln 
        35                  40                  45              


Glu Asp Leu Phe Ile Arg Asn Lys Glu Thr Asn Glu Ile Glu Lys Arg 
    50                  55                  60                  


Ser Lys Glu Glu Ile Gln Ala Val Leu Leu Glu Arg Val His Lys Gln 
65                  70                  75                  80  


Gln Gln Arg Asn Gln Trp Ser Gly Glu Val Asp Glu Gln Thr Leu Leu 
                85                  90                  95      


Gln Ala Leu Arg Gln Leu Tyr Glu Glu Ile Val Pro Ser Val Ile Gly 
            100                 105                 110         


Lys Ser Gly Asn Ala Ser Leu Lys Ala Arg Phe Phe Leu Gly Pro Leu 
        115                 120                 125             


Val Asp Pro Asn Asn Lys Thr Thr Lys Asp Val Ser Lys Ser Gly Pro 
    130                 135                 140                 


Thr Pro Lys Trp Lys Lys Met Lys Asp Ala Gly Asp Pro Asn Trp Val 
145                 150                 155                 160 


Gln Glu Tyr Glu Lys Tyr Met Ala Glu Arg Gln Thr Leu Val Arg Leu 
                165                 170                 175     


Glu Glu Met Gly Leu Ile Pro Leu Phe Pro Met Tyr Thr Asp Glu Val 
            180                 185                 190         


Gly Asp Ile His Trp Leu Pro Gln Ala Ser Gly Tyr Thr Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Phe Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Arg Arg Val Arg Glu Arg Arg Ala Gln Phe Glu Lys Lys 
225                 230                 235                 240 


Thr His Asp Phe Ala Ser Arg Phe Ser Glu Ser Asp Val Gln Trp Met 
                245                 250                 255     


Asn Lys Leu Arg Glu Tyr Glu Ala Gln Gln Glu Lys Ser Leu Glu Glu 
            260                 265                 270         


Asn Ala Phe Ala Pro Asn Glu Pro Tyr Ala Leu Thr Lys Lys Ala Leu 
        275                 280                 285             


Arg Gly Trp Glu Arg Val Tyr His Ser Trp Met Arg Leu Asp Ser Ala 
    290                 295                 300                 


Ala Ser Glu Glu Ala Tyr Trp Gln Glu Val Ala Thr Cys Gln Thr Ala 
305                 310                 315                 320 


Met Arg Gly Glu Phe Gly Asp Pro Ala Ile Tyr Gln Phe Leu Ala Gln 
                325                 330                 335     


Lys Glu Asn His Asp Ile Trp Arg Gly Tyr Pro Glu Arg Val Ile Asp 
            340                 345                 350         


Phe Ala Glu Leu Asn His Leu Gln Arg Glu Leu Arg Arg Ala Lys Glu 
        355                 360                 365             


Asp Ala Thr Phe Thr Leu Pro Asp Ser Val Asp His Pro Leu Trp Val 
    370                 375                 380                 


Arg Tyr Glu Ala Pro Gly Gly Thr Asn Ile His Gly Tyr Asp Leu Val 
385                 390                 395                 400 


Gln Asp Thr Lys Arg Asn Leu Thr Leu Ile Leu Asp Lys Phe Ile Leu 
                405                 410                 415     


Pro Asp Glu Asn Gly Ser Trp His Glu Val Lys Lys Val Pro Phe Ser 
            420                 425                 430         


Leu Ala Lys Ser Lys Gln Phe His Arg Gln Val Trp Leu Gln Glu Glu 
        435                 440                 445             


Gln Lys Gln Lys Lys Arg Glu Val Val Phe Tyr Asp Tyr Ser Thr Asn 
    450                 455                 460                 


Leu Pro His Leu Gly Thr Leu Ala Gly Ala Lys Leu Gln Trp Asp Arg 
465                 470                 475                 480 


Asn Phe Leu Asn Lys Arg Thr Gln Gln Gln Ile Glu Glu Thr Gly Glu 
                485                 490                 495     


Ile Gly Lys Val Phe Phe Asn Ile Ser Val Asp Val Arg Pro Ala Val 
            500                 505                 510         


Glu Val Lys Asn Gly Arg Leu Gln Asn Gly Leu Gly Lys Ala Leu Thr 
        515                 520                 525             


Val Leu Thr His Pro Asp Gly Thr Lys Ile Val Thr Gly Trp Lys Ala 
    530                 535                 540                 


Glu Gln Leu Glu Lys Trp Val Gly Glu Ser Gly Arg Val Ser Ser Leu 
545                 550                 555                 560 


Gly Leu Asp Ser Leu Ser Glu Gly Leu Arg Val Met Ser Ile Asp Leu 
                565                 570                 575     


Gly Gln Arg Thr Ser Ala Thr Val Ser Val Phe Glu Ile Thr Lys Glu 
            580                 585                 590         


Ala Pro Asp Asn Pro Tyr Lys Phe Phe Tyr Gln Leu Glu Gly Thr Glu 
        595                 600                 605             


Met Phe Ala Val His Gln Arg Ser Phe Leu Leu Ala Leu Pro Gly Glu 
    610                 615                 620                 


Asn Pro Pro Gln Lys Ile Lys Gln Met Arg Glu Ile Arg Trp Lys Glu 
625                 630                 635                 640 


Arg Asn Arg Ile Lys Gln Gln Val Asp Gln Leu Ser Ala Ile Leu Arg 
                645                 650                 655     


Leu His Lys Lys Val Asn Glu Asp Glu Arg Ile Gln Ala Ile Asp Lys 
            660                 665                 670         


Leu Leu Gln Lys Val Ala Ser Trp Gln Leu Asn Glu Glu Ile Ala Thr 
        675                 680                 685             


Ala Trp Asn Gln Ala Leu Ser Gln Leu Tyr Ser Lys Ala Lys Glu Asn 
    690                 695                 700                 


Asp Leu Gln Trp Asn Gln Ala Ile Lys Asn Ala His His Gln Leu Glu 
705                 710                 715                 720 


Pro Val Val Gly Lys Gln Ile Ser Leu Trp Arg Lys Asp Leu Ser Thr 
                725                 730                 735     


Gly Arg Gln Gly Ile Ala Gly Leu Ser Leu Trp Ser Ile Glu Glu Leu 
            740                 745                 750         


Glu Ala Thr Lys Lys Leu Leu Thr Arg Trp Ser Lys Arg Ser Arg Glu 
        755                 760                 765             


Pro Gly Val Val Lys Arg Ile Glu Arg Phe Glu Thr Phe Ala Lys Gln 
    770                 775                 780                 


Ile Gln His His Ile Asn Gln Val Lys Glu Asn Arg Leu Lys Gln Leu 
785                 790                 795                 800 


Ala Asn Leu Ile Val Met Thr Ala Leu Gly Tyr Lys Tyr Asp Gln Glu 
                805                 810                 815     


Gln Lys Lys Trp Ile Glu Val Tyr Pro Ala Cys Gln Val Val Leu Phe 
            820                 825                 830         


Glu Asn Leu Arg Ser Tyr Arg Phe Ser Phe Glu Arg Ser Arg Arg Glu 
        835                 840                 845             


Asn Lys Lys Leu Met Glu Trp Ser His Arg Ser Ile Pro Lys Leu Val 
    850                 855                 860                 


Gln Met Gln Gly Glu Leu Phe Gly Leu Gln Val Ala Asp Val Tyr Ala 
865                 870                 875                 880 


Ala Tyr Ser Ser Arg Tyr His Gly Arg Thr Gly Ala Pro Gly Ile Arg 
                885                 890                 895     


Cys His Ala Leu Thr Glu Ala Asp Leu Arg Asn Glu Thr Asn Ile Ile 
            900                 905                 910         


His Glu Leu Ile Glu Ala Gly Phe Ile Lys Glu Glu His Arg Pro Tyr 
        915                 920                 925             


Leu Gln Gln Gly Asp Leu Val Pro Trp Ser Gly Gly Glu Leu Phe Ala 
    930                 935                 940                 


Thr Leu Gln Lys Pro Tyr Asp Asn Pro Arg Ile Leu Thr Leu His Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala Gln Asn Ile Gln Lys Arg Phe Trp His Pro Ser 
                965                 970                 975     


Met Trp Phe Arg Val Asn Cys Glu Ser Val Met Glu Gly Glu Ile Val 
            980                 985                 990         


Thr Tyr Val Pro Lys Asn Lys Thr  Val His Lys Lys Gln  Gly Lys Thr 
        995                 1000                 1005             


Phe Arg  Phe Val Lys Val Glu  Gly Ser Asp Val Tyr  Glu Trp Ala 
    1010                 1015                 1020             


Lys Trp  Ser Lys Asn Arg Asn  Lys Asn Thr Phe Ser  Ser Ile Thr 
    1025                 1030                 1035             


Glu Arg  Lys Pro Pro Ser Ser  Met Ile Leu Phe Arg  Asp Pro Ser 
    1040                 1045                 1050             


Gly Thr  Phe Phe Lys Glu Gln  Glu Trp Val Glu Gln  Lys Thr Phe 
    1055                 1060                 1065             


Trp Gly  Lys Val Gln Ser Met  Ile Gln Ala Tyr Met  Lys Lys Thr 
    1070                 1075                 1080             


Ile Val  Gln Arg Met Glu Glu  
    1085                 1090 


<210>  60
<211>  1194
<212>  PRT
<213>  Dsulfonatronum thiodismutans

<400>  60

Met Val Leu Gly Arg Lys Asp Asp Thr Ala Glu Leu Arg Arg Ala Leu 
1               5                   10                  15      


Trp Thr Thr His Glu His Val Asn Leu Ala Val Ala Glu Val Glu Arg 
            20                  25                  30          


Val Leu Leu Arg Cys Arg Gly Arg Ser Tyr Trp Thr Leu Asp Arg Arg 
        35                  40                  45              


Gly Asp Pro Val His Val Pro Glu Ser Gln Val Ala Glu Asp Ala Leu 
    50                  55                  60                  


Ala Met Ala Arg Glu Ala Gln Arg Arg Asn Gly Trp Pro Val Val Gly 
65                  70                  75                  80  


Glu Asp Glu Glu Ile Leu Leu Ala Leu Arg Tyr Leu Tyr Glu Gln Ile 
                85                  90                  95      


Val Pro Ser Cys Leu Leu Asp Asp Leu Gly Lys Pro Leu Lys Gly Asp 
            100                 105                 110         


Ala Gln Lys Ile Gly Thr Asn Tyr Ala Gly Pro Leu Phe Asp Ser Asp 
        115                 120                 125             


Thr Cys Arg Arg Asp Glu Gly Lys Asp Val Ala Cys Cys Gly Pro Phe 
    130                 135                 140                 


His Glu Val Ala Gly Lys Tyr Leu Gly Ala Leu Pro Glu Trp Ala Thr 
145                 150                 155                 160 


Pro Ile Ser Lys Gln Glu Phe Asp Gly Lys Asp Ala Ser His Leu Arg 
                165                 170                 175     


Phe Lys Ala Thr Gly Gly Asp Asp Ala Phe Phe Arg Val Ser Ile Glu 
            180                 185                 190         


Lys Ala Asn Ala Trp Tyr Glu Asp Pro Ala Asn Gln Asp Ala Leu Lys 
        195                 200                 205             


Asn Lys Ala Tyr Asn Lys Asp Asp Trp Lys Lys Glu Lys Asp Lys Gly 
    210                 215                 220                 


Ile Ser Ser Trp Ala Val Lys Tyr Ile Gln Lys Gln Leu Gln Leu Gly 
225                 230                 235                 240 


Gln Asp Pro Arg Thr Glu Val Arg Arg Lys Leu Trp Leu Glu Leu Gly 
                245                 250                 255     


Leu Leu Pro Leu Phe Ile Pro Val Phe Asp Lys Thr Met Val Gly Asn 
            260                 265                 270         


Leu Trp Asn Arg Leu Ala Val Arg Leu Ala Leu Ala His Leu Leu Ser 
        275                 280                 285             


Trp Glu Ser Trp Asn His Arg Ala Val Gln Asp Gln Ala Leu Ala Arg 
    290                 295                 300                 


Ala Lys Arg Asp Glu Leu Ala Ala Leu Phe Leu Gly Met Glu Asp Gly 
305                 310                 315                 320 


Phe Ala Gly Leu Arg Glu Tyr Glu Leu Arg Arg Asn Glu Ser Ile Lys 
                325                 330                 335     


Gln His Ala Phe Glu Pro Val Asp Arg Pro Tyr Val Val Ser Gly Arg 
            340                 345                 350         


Ala Leu Arg Ser Trp Thr Arg Val Arg Glu Glu Trp Leu Arg His Gly 
        355                 360                 365             


Asp Thr Gln Glu Ser Arg Lys Asn Ile Cys Asn Arg Leu Gln Asp Arg 
    370                 375                 380                 


Leu Arg Gly Lys Phe Gly Asp Pro Asp Val Phe His Trp Leu Ala Glu 
385                 390                 395                 400 


Asp Gly Gln Glu Ala Leu Trp Lys Glu Arg Asp Cys Val Thr Ser Phe 
                405                 410                 415     


Ser Leu Leu Asn Asp Ala Asp Gly Leu Leu Glu Lys Arg Lys Gly Tyr 
            420                 425                 430         


Ala Leu Met Thr Phe Ala Asp Ala Arg Leu His Pro Arg Trp Ala Met 
        435                 440                 445             


Tyr Glu Ala Pro Gly Gly Ser Asn Leu Arg Thr Tyr Gln Ile Arg Lys 
    450                 455                 460                 


Thr Glu Asn Gly Leu Trp Ala Asp Val Val Leu Leu Ser Pro Arg Asn 
465                 470                 475                 480 


Glu Ser Ala Ala Val Glu Glu Lys Thr Phe Asn Val Arg Leu Ala Pro 
                485                 490                 495     


Ser Gly Gln Leu Ser Asn Val Ser Phe Asp Gln Ile Gln Lys Gly Ser 
            500                 505                 510         


Lys Met Val Gly Arg Cys Arg Tyr Gln Ser Ala Asn Gln Gln Phe Glu 
        515                 520                 525             


Gly Leu Leu Gly Gly Ala Glu Ile Leu Phe Asp Arg Lys Arg Ile Ala 
    530                 535                 540                 


Asn Glu Gln His Gly Ala Thr Asp Leu Ala Ser Lys Pro Gly His Val 
545                 550                 555                 560 


Trp Phe Lys Leu Thr Leu Asp Val Arg Pro Gln Ala Pro Gln Gly Trp 
                565                 570                 575     


Leu Asp Gly Lys Gly Arg Pro Ala Leu Pro Pro Glu Ala Lys His Phe 
            580                 585                 590         


Lys Thr Ala Leu Ser Asn Lys Ser Lys Phe Ala Asp Gln Val Arg Pro 
        595                 600                 605             


Gly Leu Arg Val Leu Ser Val Asp Leu Gly Val Arg Ser Phe Ala Ala 
    610                 615                 620                 


Cys Ser Val Phe Glu Leu Val Arg Gly Gly Pro Asp Gln Gly Thr Tyr 
625                 630                 635                 640 


Phe Pro Ala Ala Asp Gly Arg Thr Val Asp Asp Pro Glu Lys Leu Trp 
                645                 650                 655     


Ala Lys His Glu Arg Ser Phe Lys Ile Thr Leu Pro Gly Glu Asn Pro 
            660                 665                 670         


Ser Arg Lys Glu Glu Ile Ala Arg Arg Ala Ala Met Glu Glu Leu Arg 
        675                 680                 685             


Ser Leu Asn Gly Asp Ile Arg Arg Leu Lys Ala Ile Leu Arg Leu Ser 
    690                 695                 700                 


Val Leu Gln Glu Asp Asp Pro Arg Thr Glu His Leu Arg Leu Phe Met 
705                 710                 715                 720 


Glu Ala Ile Val Asp Asp Pro Ala Lys Ser Ala Leu Asn Ala Glu Leu 
                725                 730                 735     


Phe Lys Gly Phe Gly Asp Asp Arg Phe Arg Ser Thr Pro Asp Leu Trp 
            740                 745                 750         


Lys Gln His Cys His Phe Phe His Asp Lys Ala Glu Lys Val Val Ala 
        755                 760                 765             


Glu Arg Phe Ser Arg Trp Arg Thr Glu Thr Arg Pro Lys Ser Ser Ser 
    770                 775                 780                 


Trp Gln Asp Trp Arg Glu Arg Arg Gly Tyr Ala Gly Gly Lys Ser Tyr 
785                 790                 795                 800 


Trp Ala Val Thr Tyr Leu Glu Ala Val Arg Gly Leu Ile Leu Arg Trp 
                805                 810                 815     


Asn Met Arg Gly Arg Thr Tyr Gly Glu Val Asn Arg Gln Asp Lys Lys 
            820                 825                 830         


Gln Phe Gly Thr Val Ala Ser Ala Leu Leu His His Ile Asn Gln Leu 
        835                 840                 845             


Lys Glu Asp Arg Ile Lys Thr Gly Ala Asp Met Ile Ile Gln Ala Ala 
    850                 855                 860                 


Arg Gly Phe Val Pro Arg Lys Asn Gly Ala Gly Trp Val Gln Val His 
865                 870                 875                 880 


Glu Pro Cys Arg Leu Ile Leu Phe Glu Asp Leu Ala Arg Tyr Arg Phe 
                885                 890                 895     


Arg Thr Asp Arg Ser Arg Arg Glu Asn Ser Arg Leu Met Arg Trp Ser 
            900                 905                 910         


His Arg Glu Ile Val Asn Glu Val Gly Met Gln Gly Glu Leu Tyr Gly 
        915                 920                 925             


Leu His Val Asp Thr Thr Glu Ala Gly Phe Ser Ser Arg Tyr Leu Ala 
    930                 935                 940                 


Ser Ser Gly Ala Pro Gly Val Arg Cys Arg His Leu Val Glu Glu Asp 
945                 950                 955                 960 


Phe His Asp Gly Leu Pro Gly Met His Leu Val Gly Glu Leu Asp Trp 
                965                 970                 975     


Leu Leu Pro Lys Asp Lys Asp Arg Thr Ala Asn Glu Ala Arg Arg Leu 
            980                 985                 990         


Leu Gly Gly Met Val Arg Pro Gly  Met Leu Val Pro Trp  Asp Gly Gly 
        995                 1000                 1005             


Glu Leu  Phe Ala Thr Leu Asn  Ala Ala Ser Gln Leu  His Val Ile 
    1010                 1015                 1020             


His Ala  Asp Ile Asn Ala Ala  Gln Asn Leu Gln Arg  Arg Phe Trp 
    1025                 1030                 1035             


Gly Arg  Cys Gly Glu Ala Ile  Arg Ile Val Cys Asn  Gln Leu Ser 
    1040                 1045                 1050             


Val Asp  Gly Ser Thr Arg Tyr  Glu Met Ala Lys Ala  Pro Lys Ala 
    1055                 1060                 1065             


Arg Leu  Leu Gly Ala Leu Gln  Gln Leu Lys Asn Gly  Asp Ala Pro 
    1070                 1075                 1080             


Phe His  Leu Thr Ser Ile Pro  Asn Ser Gln Lys Pro  Glu Asn Ser 
    1085                 1090                 1095             


Tyr Val  Met Thr Pro Thr Asn  Ala Gly Lys Lys Tyr  Arg Ala Gly 
    1100                 1105                 1110             


Pro Gly  Glu Lys Ser Ser Gly  Glu Glu Asp Glu Leu  Ala Leu Asp 
    1115                 1120                 1125             


Ile Val  Glu Gln Ala Glu Glu  Leu Ala Gln Gly Arg  Lys Thr Phe 
    1130                 1135                 1140             


Phe Arg  Asp Pro Ser Gly Val  Phe Phe Ala Pro Asp  Arg Trp Leu 
    1145                 1150                 1155             


Pro Ser  Glu Ile Tyr Trp Ser  Arg Ile Arg Arg Arg  Ile Trp Gln 
    1160                 1165                 1170             


Val Thr  Leu Glu Arg Asn Ser  Ser Gly Arg Gln Glu  Arg Ala Glu 
    1175                 1180                 1185             


Met Asp  Glu Met Pro Tyr 
    1190                 


<210>  61
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  61

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  62
<211>  1082
<212>  PRT
<213>  Geobacillus thermodenitrificans

<400>  62

Met Lys Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Phe Val Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asn Lys Leu Phe Glu Lys Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Ile Leu Leu His Leu Ala Lys Arg Arg Gly Phe Arg 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Thr Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Gln Ser Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Ala Glu Met Val Val Lys Asp Pro Lys Phe Ser Leu His Lys Arg Asn 
                165                 170                 175     


Lys Glu Asp Asn Tyr Thr Asn Thr Val Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Lys Leu Ile Phe Ala Lys Gln Arg Glu Tyr Gly Asn Ile Val 
        195                 200                 205             


Cys Thr Glu Ala Phe Glu His Glu Tyr Ile Ser Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Phe Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Thr Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 
            260                 265                 270         


Pro Gly Gly Ile Arg Ala Leu Thr Asp Asp Glu Arg Arg Leu Ile Tyr 
        275                 280                 285             


Lys Gln Ala Phe His Lys Asn Lys Ile Thr Phe His Asp Val Arg Thr 
    290                 295                 300                 


Leu Leu Asn Leu Pro Asp Asp Thr Arg Phe Lys Gly Leu Leu Tyr Asp 
305                 310                 315                 320 


Arg Asn Thr Thr Leu Lys Glu Asn Glu Lys Val Arg Phe Leu Glu Leu 
                325                 330                 335     


Gly Ala Tyr His Lys Ile Arg Lys Ala Ile Asp Ser Val Tyr Gly Lys 
            340                 345                 350         


Gly Ala Ala Lys Ser Phe Arg Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Met Phe Lys Asp Asp Thr Asp Ile Arg Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Glu Asn Leu Ala Asp Lys 
385                 390                 395                 400 


Val Tyr Asp Glu Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Ser 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Asn Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Thr Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Val Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Glu Leu Ser Gln Ser Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Met Gln Lys Glu Gln Glu Gly Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Val Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


Leu Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Lys Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Ala Glu Tyr Leu Gly Leu Gly Ser Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Asn 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Leu Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Asp Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Ile Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Asn Phe Asn Lys Asn Arg Glu Glu Ser Asn Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Ala Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Arg Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ser 
            740                 745                 750         


Lys Lys Thr Asp Pro Gln Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Gln Ala Arg Leu Ser Lys Asn Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asn Glu Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Ile Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Lys Lys Leu Ser Glu Ile Gln Leu Asp Lys 
        835                 840                 845             


Thr Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Leu Gly 
                885                 890                 895     


Pro Ile Ile Arg Thr Ile Lys Ile Ile Asp Thr Thr Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Ile Tyr 
    930                 935                 940                 


Thr Ile Asp Met Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Phe Pro Arg 
            980                 985                 990         


Glu Lys Thr Ile Lys Thr Ala Val  Gly Glu Glu Ile Lys  Ile Lys Asp 
        995                 1000                 1005             


Leu Phe  Ala Tyr Tyr Gln Thr  Ile Asp Ser Ser Asn  Gly Gly Leu 
    1010                 1015                 1020             


Ser Leu  Val Ser His Asp Asn  Asn Phe Ser Leu Arg  Ser Ile Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Val Ala 
    1055                 1060                 1065             


Ser Ser  Ser His Ser Lys Ala  Gly Glu Thr Ile Arg  Pro Leu 
    1070                 1075                 1080         


<210>  63
<211>  887
<212>  PRT
<213>  Natronobacterium gregoryi

<400>  63

Met Thr Val Ile Asp Leu Asp Ser Thr Thr Thr Ala Asp Glu Leu Thr 
1               5                   10                  15      


Ser Gly His Thr Tyr Asp Ile Ser Val Thr Leu Thr Gly Val Tyr Asp 
            20                  25                  30          


Asn Thr Asp Glu Gln His Pro Arg Met Ser Leu Ala Phe Glu Gln Asp 
        35                  40                  45              


Asn Gly Glu Arg Arg Tyr Ile Thr Leu Trp Lys Asn Thr Thr Pro Lys 
    50                  55                  60                  


Asp Val Phe Thr Tyr Asp Tyr Ala Thr Gly Ser Thr Tyr Ile Phe Thr 
65                  70                  75                  80  


Asn Ile Asp Tyr Glu Val Lys Asp Gly Tyr Glu Asn Leu Thr Ala Thr 
                85                  90                  95      


Tyr Gln Thr Thr Val Glu Asn Ala Thr Ala Gln Glu Val Gly Thr Thr 
            100                 105                 110         


Asp Glu Asp Glu Thr Phe Ala Gly Gly Glu Pro Leu Asp His His Leu 
        115                 120                 125             


Asp Asp Ala Leu Asn Glu Thr Pro Asp Asp Ala Glu Thr Glu Ser Asp 
    130                 135                 140                 


Ser Gly His Val Met Thr Ser Phe Ala Ser Arg Asp Gln Leu Pro Glu 
145                 150                 155                 160 


Trp Thr Leu His Thr Tyr Thr Leu Thr Ala Thr Asp Gly Ala Lys Thr 
                165                 170                 175     


Asp Thr Glu Tyr Ala Arg Arg Thr Leu Ala Tyr Thr Val Arg Gln Glu 
            180                 185                 190         


Leu Tyr Thr Asp His Asp Ala Ala Pro Val Ala Thr Asp Gly Leu Met 
        195                 200                 205             


Leu Leu Thr Pro Glu Pro Leu Gly Glu Thr Pro Leu Asp Leu Asp Cys 
    210                 215                 220                 


Gly Val Arg Val Glu Ala Asp Glu Thr Arg Thr Leu Asp Tyr Thr Thr 
225                 230                 235                 240 


Ala Lys Asp Arg Leu Leu Ala Arg Glu Leu Val Glu Glu Gly Leu Lys 
                245                 250                 255     


Arg Ser Leu Trp Asp Asp Tyr Leu Val Arg Gly Ile Asp Glu Val Leu 
            260                 265                 270         


Ser Lys Glu Pro Val Leu Thr Cys Asp Glu Phe Asp Leu His Glu Arg 
        275                 280                 285             


Tyr Asp Leu Ser Val Glu Val Gly His Ser Gly Arg Ala Tyr Leu His 
    290                 295                 300                 


Ile Asn Phe Arg His Arg Phe Val Pro Lys Leu Thr Leu Ala Asp Ile 
305                 310                 315                 320 


Asp Asp Asp Asn Ile Tyr Pro Gly Leu Arg Val Lys Thr Thr Tyr Arg 
                325                 330                 335     


Pro Arg Arg Gly His Ile Val Trp Gly Leu Arg Asp Glu Cys Ala Thr 
            340                 345                 350         


Asp Ser Leu Asn Thr Leu Gly Asn Gln Ser Val Val Ala Tyr His Arg 
        355                 360                 365             


Asn Asn Gln Thr Pro Ile Asn Thr Asp Leu Leu Asp Ala Ile Glu Ala 
    370                 375                 380                 


Ala Asp Arg Arg Val Val Glu Thr Arg Arg Gln Gly His Gly Asp Asp 
385                 390                 395                 400 


Ala Val Ser Phe Pro Gln Glu Leu Leu Ala Val Glu Pro Asn Thr His 
                405                 410                 415     


Gln Ile Lys Gln Phe Ala Ser Asp Gly Phe His Gln Gln Ala Arg Ser 
            420                 425                 430         


Lys Thr Arg Leu Ser Ala Ser Arg Cys Ser Glu Lys Ala Gln Ala Phe 
        435                 440                 445             


Ala Glu Arg Leu Asp Pro Val Arg Leu Asn Gly Ser Thr Val Glu Phe 
    450                 455                 460                 


Ser Ser Glu Phe Phe Thr Gly Asn Asn Glu Gln Gln Leu Arg Leu Leu 
465                 470                 475                 480 


Tyr Glu Asn Gly Glu Ser Val Leu Thr Phe Arg Asp Gly Ala Arg Gly 
                485                 490                 495     


Ala His Pro Asp Glu Thr Phe Ser Lys Gly Ile Val Asn Pro Pro Glu 
            500                 505                 510         


Ser Phe Glu Val Ala Val Val Leu Pro Glu Gln Gln Ala Asp Thr Cys 
        515                 520                 525             


Lys Ala Gln Trp Asp Thr Met Ala Asp Leu Leu Asn Gln Ala Gly Ala 
    530                 535                 540                 


Pro Pro Thr Arg Ser Glu Thr Val Gln Tyr Asp Ala Phe Ser Ser Pro 
545                 550                 555                 560 


Glu Ser Ile Ser Leu Asn Val Ala Gly Ala Ile Asp Pro Ser Glu Val 
                565                 570                 575     


Asp Ala Ala Phe Val Val Leu Pro Pro Asp Gln Glu Gly Phe Ala Asp 
            580                 585                 590         


Leu Ala Ser Pro Thr Glu Thr Tyr Asp Glu Leu Lys Lys Ala Leu Ala 
        595                 600                 605             


Asn Met Gly Ile Tyr Ser Gln Met Ala Tyr Phe Asp Arg Phe Arg Asp 
    610                 615                 620                 


Ala Lys Ile Phe Tyr Thr Arg Asn Val Ala Leu Gly Leu Leu Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Val Ala Phe Thr Thr Glu His Ala Met Pro Gly Asp Ala 
                645                 650                 655     


Asp Met Phe Ile Gly Ile Asp Val Ser Arg Ser Tyr Pro Glu Asp Gly 
            660                 665                 670         


Ala Ser Gly Gln Ile Asn Ile Ala Ala Thr Ala Thr Ala Val Tyr Lys 
        675                 680                 685             


Asp Gly Thr Ile Leu Gly His Ser Ser Thr Arg Pro Gln Leu Gly Glu 
    690                 695                 700                 


Lys Leu Gln Ser Thr Asp Val Arg Asp Ile Met Lys Asn Ala Ile Leu 
705                 710                 715                 720 


Gly Tyr Gln Gln Val Thr Gly Glu Ser Pro Thr His Ile Val Ile His 
                725                 730                 735     


Arg Asp Gly Phe Met Asn Glu Asp Leu Asp Pro Ala Thr Glu Phe Leu 
            740                 745                 750         


Asn Glu Gln Gly Val Glu Tyr Asp Ile Val Glu Ile Arg Lys Gln Pro 
        755                 760                 765             


Gln Thr Arg Leu Leu Ala Val Ser Asp Val Gln Tyr Asp Thr Pro Val 
    770                 775                 780                 


Lys Ser Ile Ala Ala Ile Asn Gln Asn Glu Pro Arg Ala Thr Val Ala 
785                 790                 795                 800 


Thr Phe Gly Ala Pro Glu Tyr Leu Ala Thr Arg Asp Gly Gly Gly Leu 
                805                 810                 815     


Pro Arg Pro Ile Gln Ile Glu Arg Val Ala Gly Glu Thr Asp Ile Glu 
            820                 825                 830         


Thr Leu Thr Arg Gln Val Tyr Leu Leu Ser Gln Ser His Ile Gln Val 
        835                 840                 845             


His Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Ala Tyr Ala Asp Gln 
    850                 855                 860                 


Ala Ser Thr His Ala Thr Lys Gly Tyr Leu Val Gln Thr Gly Ala Phe 
865                 870                 875                 880 


Glu Ser Asn Val Gly Phe Leu 
                885         


<210>  64
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln 
1               5                   10                  15      


Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
            20                  25                  30          


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
        35                  40                  45              


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
    50                  55                  60                  


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
65                  70                  75                  80  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
                85                  90                  95      


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
            100                 105                 110         


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
        115                 120                 125             


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
    130                 135                 140                 


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
145                 150                 155                 160 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
                165                 170                 175     


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
            180                 185                 190         


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
        195                 200                 205             


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
    210                 215                 220                 


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
225                 230                 235                 240 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
                245                 250                 255     


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
            260                 265                 270         


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
        275                 280                 285             


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
    290                 295                 300                 


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
305                 310                 315                 320 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
                325                 330                 335     


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
            340                 345                 350         


Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly 
    370                 375                 380                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
385                 390                 395                 400 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                405                 410                 415     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            420                 425                 430         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        435                 440                 445             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    450                 455                 460                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
465                 470                 475                 480 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                485                 490                 495     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            500                 505                 510         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        515                 520                 525             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    530                 535                 540                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
545                 550                 555                 560 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                565                 570                 575     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            580                 585                 590         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        595                 600                 605             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    610                 615                 620                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
625                 630                 635                 640 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                645                 650                 655     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            660                 665                 670         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        675                 680                 685             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    690                 695                 700                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
705                 710                 715                 720 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                725                 730                 735     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            740                 745                 750         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        755                 760                 765             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    770                 775                 780                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
785                 790                 795                 800 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                805                 810                 815     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            820                 825                 830         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        835                 840                 845             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    850                 855                 860                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
865                 870                 875                 880 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                885                 890                 895     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            900                 905                 910         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        915                 920                 925             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    930                 935                 940                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
945                 950                 955                 960 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                965                 970                 975     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            980                 985                 990         


Glu Asp Ile Val Leu Thr Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile 
        995                 1000                 1005             


Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
    1010                 1015                 1020             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1025                 1030                 1035             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1040                 1045                 1050             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1055                 1060                 1065             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1070                 1075                 1080             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1085                 1090                 1095             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1100                 1105                 1110             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1115                 1120                 1125             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1130                 1135                 1140             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1145                 1150                 1155             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1160                 1165                 1170             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1175                 1180                 1185             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1190                 1195                 1200             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1205                 1210                 1215             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1220                 1225                 1230             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1235                 1240                 1245             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1250                 1255                 1260             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1265                 1270                 1275             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1280                 1285                 1290             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1295                 1300                 1305             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1310                 1315                 1320             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1325                 1330                 1335             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1340                 1345                 1350             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1355                 1360                 1365             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1370                 1375                 1380             


Phe Val  Tyr Gly 
    1385         


<210>  65
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
1               5                   10                  15      


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
            20                  25                  30          


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
        35                  40                  45              


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
    50                  55                  60                  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
65                  70                  75                  80  


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
                85                  90                  95      


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
            100                 105                 110         


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
        115                 120                 125             


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
    130                 135                 140                 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
145                 150                 155                 160 


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
                165                 170                 175     


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
            180                 185                 190         


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
        195                 200                 205             


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
    210                 215                 220                 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
225                 230                 235                 240 


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
                245                 250                 255     


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
            260                 265                 270         


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
        275                 280                 285             


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
    290                 295                 300                 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
305                 310                 315                 320 


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
                325                 330                 335     


Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            340                 345                 350         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Asp Lys Lys Tyr Ser Ile 
        355                 360                 365             


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
    370                 375                 380                 


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
385                 390                 395                 400 


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
                405                 410                 415     


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
            420                 425                 430         


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
        435                 440                 445             


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
    450                 455                 460                 


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
465                 470                 475                 480 


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
                485                 490                 495     


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
            500                 505                 510         


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
        515                 520                 525             


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
    530                 535                 540                 


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
545                 550                 555                 560 


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
                565                 570                 575     


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
            580                 585                 590         


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
        595                 600                 605             


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
    610                 615                 620                 


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
625                 630                 635                 640 


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
                645                 650                 655     


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
            660                 665                 670         


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
        675                 680                 685             


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
    690                 695                 700                 


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
705                 710                 715                 720 


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
                725                 730                 735     


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
            740                 745                 750         


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
        755                 760                 765             


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
    770                 775                 780                 


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
785                 790                 795                 800 


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                805                 810                 815     


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
            820                 825                 830         


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
        835                 840                 845             


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
    850                 855                 860                 


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
865                 870                 875                 880 


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
                885                 890                 895     


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
            900                 905                 910         


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
        915                 920                 925             


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
    930                 935                 940                 


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
945                 950                 955                 960 


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
                965                 970                 975     


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
            980                 985                 990         


Ile Glu Glu Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
        995                 1000                 1005             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1010                 1015                 1020             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1025                 1030                 1035             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1040                 1045                 1050             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1055                 1060                 1065             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1070                 1075                 1080             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1085                 1090                 1095             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1100                 1105                 1110             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1115                 1120                 1125             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1130                 1135                 1140             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1145                 1150                 1155             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1160                 1165                 1170             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1175                 1180                 1185             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1190                 1195                 1200             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1205                 1210                 1215             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1220                 1225                 1230             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1235                 1240                 1245             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1250                 1255                 1260             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1265                 1270                 1275             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1280                 1285                 1290             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1295                 1300                 1305             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1310                 1315                 1320             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1325                 1330                 1335             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1340                 1345                 1350             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1355                 1360                 1365             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1370                 1375                 1380             


Ala Lys  Ser Glu Gln 
    1385             


<210>  66
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu 
1               5                   10                  15      


Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile 
            20                  25                  30          


Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser 
        35                  40                  45              


Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly 
    50                  55                  60                  


Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile 
65                  70                  75                  80  


Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser 
                85                  90                  95      


Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly 
            100                 105                 110         


Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile 
        115                 120                 125             


Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala 
    130                 135                 140                 


Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys 
145                 150                 155                 160 


Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser 
                165                 170                 175     


Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr 
            180                 185                 190         


Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 
        195                 200                 205             


Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
    210                 215                 220                 


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
225                 230                 235                 240 


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
                245                 250                 255     


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
            260                 265                 270         


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
        275                 280                 285             


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
    290                 295                 300                 


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr 
            340                 345                 350         


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
        355                 360                 365             


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
    370                 375                 380                 


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
385                 390                 395                 400 


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
                405                 410                 415     


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
            420                 425                 430         


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
        435                 440                 445             


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
    450                 455                 460                 


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
465                 470                 475                 480 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
                485                 490                 495     


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
            500                 505                 510         


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
        515                 520                 525             


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
    530                 535                 540                 


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
545                 550                 555                 560 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
                565                 570                 575     


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
            580                 585                 590         


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
        595                 600                 605             


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
    610                 615                 620                 


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
625                 630                 635                 640 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
                645                 650                 655     


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
            660                 665                 670         


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
        675                 680                 685             


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
    690                 695                 700                 


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
705                 710                 715                 720 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
                725                 730                 735     


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
            740                 745                 750         


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
        755                 760                 765             


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
    770                 775                 780                 


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
785                 790                 795                 800 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
                805                 810                 815     


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
            820                 825                 830         


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
        835                 840                 845             


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
    850                 855                 860                 


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
865                 870                 875                 880 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
                885                 890                 895     


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
            900                 905                 910         


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
        915                 920                 925             


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
    930                 935                 940                 


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
945                 950                 955                 960 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
                965                 970                 975     


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
            980                 985                 990         


Lys Val Met Lys Gln Leu Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg 
        995                 1000                 1005             


Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly 
    1010                 1015                 1020             


Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg 
    1025                 1030                 1035             


Asn Phe  Met Gln Leu Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu 
    1040                 1045                 1050             


Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln Gly Asp  Ser Leu His 
    1055                 1060                 1065             


Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly 
    1070                 1075                 1080             


Ile Leu  Gln Thr Val Lys Val  Val Asp Glu Leu Val  Lys Val Met 
    1085                 1090                 1095             


Gly Arg  His Lys Pro Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu 
    1100                 1105                 1110             


Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met 
    1115                 1120                 1125             


Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu 
    1130                 1135                 1140             


Lys Glu  His Pro Val Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu 
    1145                 1150                 1155             


Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
    1160                 1165                 1170             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1175                 1180                 1185             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1190                 1195                 1200             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1205                 1210                 1215             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1220                 1225                 1230             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1235                 1240                 1245             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1250                 1255                 1260             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1265                 1270                 1275             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1280                 1285                 1290             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1295                 1300                 1305             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1310                 1315                 1320             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1325                 1330                 1335             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1340                 1345                 1350             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1355                 1360                 1365             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1370                 1375                 1380             


Phe Phe  Tyr Ser 
    1385         


<210>  67
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
1               5                   10                  15      


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
            20                  25                  30          


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
        35                  40                  45              


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
    50                  55                  60                  


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
65                  70                  75                  80  


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
                85                  90                  95      


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
            100                 105                 110         


Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Asp Lys Lys 
    130                 135                 140                 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
145                 150                 155                 160 


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
                165                 170                 175     


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
            180                 185                 190         


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
        195                 200                 205             


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
    210                 215                 220                 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
225                 230                 235                 240 


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
                245                 250                 255     


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
            260                 265                 270         


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
        275                 280                 285             


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
    290                 295                 300                 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
305                 310                 315                 320 


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
                325                 330                 335     


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
            340                 345                 350         


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
        355                 360                 365             


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
    370                 375                 380                 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
385                 390                 395                 400 


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
                405                 410                 415     


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
            420                 425                 430         


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
        435                 440                 445             


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
    450                 455                 460                 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
465                 470                 475                 480 


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
                485                 490                 495     


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
            500                 505                 510         


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
        515                 520                 525             


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
    530                 535                 540                 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
545                 550                 555                 560 


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
                565                 570                 575     


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
            580                 585                 590         


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
        595                 600                 605             


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
    610                 615                 620                 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
625                 630                 635                 640 


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
                645                 650                 655     


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
            660                 665                 670         


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
        675                 680                 685             


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
    690                 695                 700                 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
705                 710                 715                 720 


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
                725                 730                 735     


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
            740                 745                 750         


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
        755                 760                 765             


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
    770                 775                 780                 


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
785                 790                 795                 800 


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
                805                 810                 815     


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
            820                 825                 830         


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
        835                 840                 845             


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
    850                 855                 860                 


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
865                 870                 875                 880 


Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro 
                885                 890                 895     


Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys 
            900                 905                 910         


Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile 
        915                 920                 925             


Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr 
    930                 935                 940                 


Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
945                 950                 955                 960 


Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr 
                965                 970                 975     


Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
            980                 985                 990         


Asp Asn Lys Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
        995                 1000                 1005             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1010                 1015                 1020             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1025                 1030                 1035             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1040                 1045                 1050             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1055                 1060                 1065             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1070                 1075                 1080             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1085                 1090                 1095             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1100                 1105                 1110             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1115                 1120                 1125             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1130                 1135                 1140             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1145                 1150                 1155             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1160                 1165                 1170             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1175                 1180                 1185             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1190                 1195                 1200             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1205                 1210                 1215             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1220                 1225                 1230             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1235                 1240                 1245             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1250                 1255                 1260             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1265                 1270                 1275             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1280                 1285                 1290             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1295                 1300                 1305             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1310                 1315                 1320             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1325                 1330                 1335             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1340                 1345                 1350             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1355                 1360                 1365             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1370                 1375                 1380             


Lys Leu  Lys Gly Ser 
    1385             


<210>  68
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
1               5                   10                  15      


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
            20                  25                  30          


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
        35                  40                  45              


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
    50                  55                  60                  


Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly 
                85                  90                  95      


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            100                 105                 110         


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        115                 120                 125             


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    130                 135                 140                 


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
145                 150                 155                 160 


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                165                 170                 175     


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            180                 185                 190         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        195                 200                 205             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    210                 215                 220                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
225                 230                 235                 240 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                245                 250                 255     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            260                 265                 270         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        275                 280                 285             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    290                 295                 300                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
305                 310                 315                 320 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                325                 330                 335     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            340                 345                 350         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        355                 360                 365             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    370                 375                 380                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
385                 390                 395                 400 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                405                 410                 415     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            420                 425                 430         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        435                 440                 445             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    450                 455                 460                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
465                 470                 475                 480 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                485                 490                 495     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            500                 505                 510         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        515                 520                 525             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    530                 535                 540                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
545                 550                 555                 560 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                565                 570                 575     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            580                 585                 590         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        595                 600                 605             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    610                 615                 620                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
625                 630                 635                 640 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                645                 650                 655     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            660                 665                 670         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        675                 680                 685             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    690                 695                 700                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
705                 710                 715                 720 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                725                 730                 735     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            740                 745                 750         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        755                 760                 765             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    770                 775                 780                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
785                 790                 795                 800 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                805                 810                 815     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            820                 825                 830         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        835                 840                 845             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    850                 855                 860                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
865                 870                 875                 880 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                885                 890                 895     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            900                 905                 910         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        915                 920                 925             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    930                 935                 940                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
945                 950                 955                 960 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                965                 970                 975     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            980                 985                 990         


Arg Gly Gly Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
        995                 1000                 1005             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1010                 1015                 1020             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1025                 1030                 1035             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1040                 1045                 1050             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1055                 1060                 1065             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1070                 1075                 1080             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1085                 1090                 1095             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1100                 1105                 1110             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1115                 1120                 1125             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1130                 1135                 1140             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1145                 1150                 1155             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1160                 1165                 1170             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1175                 1180                 1185             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1190                 1195                 1200             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1205                 1210                 1215             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1220                 1225                 1230             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1235                 1240                 1245             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1250                 1255                 1260             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1265                 1270                 1275             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1280                 1285                 1290             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1295                 1300                 1305             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1310                 1315                 1320             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1325                 1330                 1335             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1340                 1345                 1350             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1355                 1360                 1365             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1370                 1375                 1380             


Lys His  Arg Asp 
    1385         


<210>  69
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln 
1               5                   10                  15      


Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
            20                  25                  30          


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
        35                  40                  45              


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
    50                  55                  60                  


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
65                  70                  75                  80  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
                85                  90                  95      


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
            100                 105                 110         


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
        115                 120                 125             


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
    130                 135                 140                 


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
145                 150                 155                 160 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
                165                 170                 175     


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
            180                 185                 190         


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
        195                 200                 205             


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
    210                 215                 220                 


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
225                 230                 235                 240 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
                245                 250                 255     


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
            260                 265                 270         


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
        275                 280                 285             


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
    290                 295                 300                 


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
305                 310                 315                 320 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
                325                 330                 335     


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
            340                 345                 350         


Gln Leu Gly Gly Asp 
        355         


<210>  70
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
1               5                   10                  15      


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
            20                  25                  30          


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
        35                  40                  45              


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
    50                  55                  60                  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
65                  70                  75                  80  


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
                85                  90                  95      


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
            100                 105                 110         


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
        115                 120                 125             


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
    130                 135                 140                 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
145                 150                 155                 160 


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
                165                 170                 175     


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
            180                 185                 190         


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
        195                 200                 205             


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
    210                 215                 220                 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
225                 230                 235                 240 


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
                245                 250                 255     


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
            260                 265                 270         


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
        275                 280                 285             


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
    290                 295                 300                 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
305                 310                 315                 320 


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
                325                 330                 335     


Gln Leu Gly Gly Asp 
            340     


<210>  71
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu 
1               5                   10                  15      


Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile 
            20                  25                  30          


Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser 
        35                  40                  45              


Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly 
    50                  55                  60                  


Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile 
65                  70                  75                  80  


Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser 
                85                  90                  95      


Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly 
            100                 105                 110         


Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile 
        115                 120                 125             


Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala 
    130                 135                 140                 


Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys 
145                 150                 155                 160 


Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser 
                165                 170                 175     


Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr 
            180                 185                 190         


Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 
        195                 200                 205             


Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
    210                 215                 220                 


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
225                 230                 235                 240 


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
                245                 250                 255     


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
            260                 265                 270         


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
        275                 280                 285             


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
    290                 295                 300                 


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Leu Ser Gln Leu Gly Gly Asp 
                325             


<210>  72
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
1               5                   10                  15      


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
            20                  25                  30          


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
        35                  40                  45              


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
    50                  55                  60                  


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
65                  70                  75                  80  


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
                85                  90                  95      


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
            100                 105                 110         


Asp Leu Ser Gln Leu Gly Gly Asp 
        115                 120 


<210>  73
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
1               5                   10                  15      


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
            20                  25                  30          


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
        35                  40                  45              


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
    50                  55                  60                  


Gln Leu Gly Gly Asp 
65                  


<210>  74
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Gln Tyr  Arg Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  75
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Gln Tyr  Arg Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  76
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Glu Tyr  Arg Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  77
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Arg Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Phe Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Arg Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Val  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  78
<211>  167
<212>  PRT
<213>  Escherichia coli

<400>  78

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  79
<211>  167
<212>  PRT
<213>  Escherichia coli

<400>  79

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  80
<211>  167
<212>  PRT
<213>  Escherichia coli

<400>  80

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  81
<211>  160
<212>  PRT
<213>  Staphylococcus aureus

<400>  81

Met Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile 
1               5                   10                  15      


Glu Glu Ala Lys Lys Ala Ala Gln Leu Gly Glu Val Pro Ile Gly Ala 
            20                  25                  30          


Ile Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg 
        35                  40                  45              


Glu Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu 
    50                  55                  60                  


Arg Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met 
                85                  90                  95      


Ser Arg Ile Pro Arg Val Val Tyr Gly Ala Asp Asp Pro Lys Gly Gly 
            100                 105                 110         


Cys Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His 
        115                 120                 125             


Arg Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ser Thr Leu 
    130                 135                 140                 


Leu Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 160 


<210>  82
<211>  161
<212>  PRT
<213>  Bacillus subtilis

<400>  82

Met Thr Gln Asp Glu Leu Tyr Met Lys Glu Ala Ile Lys Glu Ala Lys 
1               5                   10                  15      


Lys Ala Glu Glu Lys Gly Glu Val Pro Ile Gly Ala Val Leu Val Ile 
            20                  25                  30          


Asn Gly Glu Ile Ile Ala Arg Ala His Asn Leu Arg Glu Thr Glu Gln 
        35                  40                  45              


Arg Ser Ile Ala His Ala Glu Met Leu Val Ile Asp Glu Ala Cys Lys 
    50                  55                  60                  


Ala Leu Gly Thr Trp Arg Leu Glu Gly Ala Thr Leu Tyr Val Thr Leu 
65                  70                  75                  80  


Glu Pro Cys Pro Met Cys Ala Gly Ala Val Val Leu Ser Arg Val Glu 
                85                  90                  95      


Lys Val Val Phe Gly Ala Phe Asp Pro Lys Gly Gly Cys Ser Gly Thr 
            100                 105                 110         


Leu Met Asn Leu Leu Gln Glu Glu Arg Phe Asn His Gln Ala Glu Val 
        115                 120                 125             


Val Ser Gly Val Leu Glu Glu Glu Cys Gly Gly Met Leu Ser Ala Phe 
    130                 135                 140                 


Phe Arg Glu Leu Arg Lys Lys Lys Lys Ala Ala Arg Lys Asn Leu Ser 
145                 150                 155                 160 


Glu 
    


<210>  83
<211>  183
<212>  PRT
<213>  Salmonella typhimurium

<400>  83

Met Pro Pro Ala Phe Ile Thr Gly Val Thr Ser Leu Ser Asp Val Glu 
1               5                   10                  15      


Leu Asp His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


His Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Leu Gln Asn Tyr Arg Leu Leu Asp Thr Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Val His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Ile Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Ile 
    130                 135                 140                 


Glu Gly Val Leu Arg Asp Glu Cys Ala Thr Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Leu Lys Lys Ala Asp Arg Ala 
                165                 170                 175     


Glu Gly Ala Gly Pro Ala Val 
            180             


<210>  84
<211>  164
<212>  PRT
<213>  Shewanella putrefaciens

<400>  84

Met Asp Glu Tyr Trp Met Gln Val Ala Met Gln Met Ala Glu Lys Ala 
1               5                   10                  15      


Glu Ala Ala Gly Glu Val Pro Val Gly Ala Val Leu Val Lys Asp Gly 
            20                  25                  30          


Gln Gln Ile Ala Thr Gly Tyr Asn Leu Ser Ile Ser Gln His Asp Pro 
        35                  40                  45              


Thr Ala His Ala Glu Ile Leu Cys Leu Arg Ser Ala Gly Lys Lys Leu 
    50                  55                  60                  


Glu Asn Tyr Arg Leu Leu Asp Ala Thr Leu Tyr Ile Thr Leu Glu Pro 
65                  70                  75                  80  


Cys Ala Met Cys Ala Gly Ala Met Val His Ser Arg Ile Ala Arg Val 
                85                  90                  95      


Val Tyr Gly Ala Arg Asp Glu Lys Thr Gly Ala Ala Gly Thr Val Val 
            100                 105                 110         


Asn Leu Leu Gln His Pro Ala Phe Asn His Gln Val Glu Val Thr Ser 
        115                 120                 125             


Gly Val Leu Ala Glu Ala Cys Ser Ala Gln Leu Ser Arg Phe Phe Lys 
    130                 135                 140                 


Arg Arg Arg Asp Glu Lys Lys Ala Leu Lys Leu Ala Gln Arg Ala Gln 
145                 150                 155                 160 


Gln Gly Ile Glu 
                


<210>  85
<211>  173
<212>  PRT
<213>  Haemophilus influenzae

<400>  85

Met Asp Ala Ala Lys Val Arg Ser Glu Phe Asp Glu Lys Met Met Arg 
1               5                   10                  15      


Tyr Ala Leu Glu Leu Ala Asp Lys Ala Glu Ala Leu Gly Glu Ile Pro 
            20                  25                  30          


Val Gly Ala Val Leu Val Asp Asp Ala Arg Asn Ile Ile Gly Glu Gly 
        35                  40                  45              


Trp Asn Leu Ser Ile Val Gln Ser Asp Pro Thr Ala His Ala Glu Ile 
    50                  55                  60                  


Ile Ala Leu Arg Asn Gly Ala Lys Asn Ile Gln Asn Tyr Arg Leu Leu 
65                  70                  75                  80  


Asn Ser Thr Leu Tyr Val Thr Leu Glu Pro Cys Thr Met Cys Ala Gly 
                85                  90                  95      


Ala Ile Leu His Ser Arg Ile Lys Arg Leu Val Phe Gly Ala Ser Asp 
            100                 105                 110         


Tyr Lys Thr Gly Ala Ile Gly Ser Arg Phe His Phe Phe Asp Asp Tyr 
        115                 120                 125             


Lys Met Asn His Thr Leu Glu Ile Thr Ser Gly Val Leu Ala Glu Glu 
    130                 135                 140                 


Cys Ser Gln Lys Leu Ser Thr Phe Phe Gln Lys Arg Arg Glu Glu Lys 
145                 150                 155                 160 


Lys Ile Glu Lys Ala Leu Leu Lys Ser Leu Ser Asp Lys 
                165                 170             


<210>  86
<211>  161
<212>  PRT
<213>  Caulobacter crescentus

<400>  86

Met Arg Thr Asp Glu Ser Glu Asp Gln Asp His Arg Met Met Arg Leu 
1               5                   10                  15      


Ala Leu Asp Ala Ala Arg Ala Ala Ala Glu Ala Gly Glu Thr Pro Val 
            20                  25                  30          


Gly Ala Val Ile Leu Asp Pro Ser Thr Gly Glu Val Ile Ala Thr Ala 
        35                  40                  45              


Gly Asn Gly Pro Ile Ala Ala His Asp Pro Thr Ala His Ala Glu Ile 
    50                  55                  60                  


Ala Ala Met Arg Ala Ala Ala Ala Lys Leu Gly Asn Tyr Arg Leu Thr 
65                  70                  75                  80  


Asp Leu Thr Leu Val Val Thr Leu Glu Pro Cys Ala Met Cys Ala Gly 
                85                  90                  95      


Ala Ile Ser His Ala Arg Ile Gly Arg Val Val Phe Gly Ala Asp Asp 
            100                 105                 110         


Pro Lys Gly Gly Ala Val Val His Gly Pro Lys Phe Phe Ala Gln Pro 
        115                 120                 125             


Thr Cys His Trp Arg Pro Glu Val Thr Gly Gly Val Leu Ala Asp Glu 
    130                 135                 140                 


Ser Ala Asp Leu Leu Arg Gly Phe Phe Arg Ala Arg Arg Lys Ala Lys 
145                 150                 155                 160 


Ile 
    


<210>  87
<211>  178
<212>  PRT
<213>  Geobacter sulfurreducens

<400>  87

Met Ser Ser Leu Lys Lys Thr Pro Ile Arg Asp Asp Ala Tyr Trp Met 
1               5                   10                  15      


Gly Lys Ala Ile Arg Glu Ala Ala Lys Ala Ala Ala Arg Asp Glu Val 
            20                  25                  30          


Pro Ile Gly Ala Val Ile Val Arg Asp Gly Ala Val Ile Gly Arg Gly 
        35                  40                  45              


His Asn Leu Arg Glu Gly Ser Asn Asp Pro Ser Ala His Ala Glu Met 
    50                  55                  60                  


Ile Ala Ile Arg Gln Ala Ala Arg Arg Ser Ala Asn Trp Arg Leu Thr 
65                  70                  75                  80  


Gly Ala Thr Leu Tyr Val Thr Leu Glu Pro Cys Leu Met Cys Met Gly 
                85                  90                  95      


Ala Ile Ile Leu Ala Arg Leu Glu Arg Val Val Phe Gly Cys Tyr Asp 
            100                 105                 110         


Pro Lys Gly Ala Ala Gly Ser Leu Tyr Asp Leu Ser Ala Asp Pro Arg 
        115                 120                 125             


Leu Asn His Gln Val Arg Leu Ser Pro Gly Val Cys Gln Glu Glu Cys 
    130                 135                 140                 


Gly Thr Met Leu Ser Asp Phe Phe Arg Asp Leu Arg Arg Arg Lys Lys 
145                 150                 155                 160 


Ala Lys Ala Thr Pro Ala Leu Phe Ile Asp Glu Arg Lys Val Pro Pro 
                165                 170                 175     


Glu Pro 
        


<210>  88
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
gtcagaagag atgtggtcaa tgg                                               23


<210>  89
<211>  178
<212>  PRT
<213>  Escherichia coli

<400>  89

Met Arg Arg Ala Phe Ile Thr Gly Val Phe Phe Leu Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp 
        


<210>  90
<211>  498
<212>  DNA
<213>  Escherichia coli

<400>  90
tctgaggtgg agttttccca cgagtactgg atgagacatg ccctgaccct ggccaagagg       60

gcacgggatg agagggaggt gcctgtggga gccgtgctgg tgctgaacaa tagagtgatc      120

ggcgagggct ggaacagagc catcggcctg cacgacccaa cagcccatgc cgaaattatg      180

gccctgagac agggcggcct ggtcatgcag aactacagac tgattgacgc caccctgtac      240

gtgacattcg agccttgcgt gatgtgcgcc ggcgccatga tccactctag gatcggccgc      300

gtggtgtttg gcgtgaggaa ctcaaaaaga ggcgccgcag gctccctgat gaacgtgctg      360

aactaccccg gcatgaatca ccgcgtcgaa attaccgagg gaatcctggc agatgaatgt      420

gccgccctgc tgtgcgattt ctatcggatg cctagacagg tgttcaatgc tcagaagaag      480

gcccagagct ccatcaac                                                    498


<210>  91
<211>  167
<212>  PRT
<213>  Escherichia coli

<400>  91

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys Arg Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Ile Asn 
                165         


<210>  92
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  92

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  93
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  93

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210>  94
<211>  198
<212>  PRT
<213>  Canis familiaris

<400>  94

Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  95
<211>  199
<212>  PRT
<213>  Bos taurus

<400>  95

Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Pro Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ala Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Thr Leu Gly Leu 
        195                 


<210>  96
<211>  239
<212>  PRT
<213>  Rattus norvegicus

<400>  96

Met Ala Val Gly Ser Lys Pro Lys Ala Ala Leu Val Gly Pro His Trp 
1               5                   10                  15      


Glu Arg Glu Arg Ile Trp Cys Phe Leu Cys Ser Thr Gly Leu Gly Thr 
            20                  25                  30          


Gln Gln Thr Gly Gln Thr Ser Arg Trp Leu Arg Pro Ala Ala Thr Gln 
        35                  40                  45              


Asp Pro Val Ser Pro Pro Arg Ser Leu Leu Met Lys Gln Arg Lys Phe 
    50                  55                  60                  


Leu Tyr His Phe Lys Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr 
65                  70                  75                  80  


Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser 
                85                  90                  95      


Leu Asp Phe Gly Tyr Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu 
            100                 105                 110         


Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys 
        115                 120                 125             


Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala 
    130                 135                 140                 


Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg 
145                 150                 155                 160 


Ile Phe Thr Ala Arg Leu Thr Gly Trp Gly Ala Leu Pro Ala Gly Leu 
                165                 170                 175     


Met Ser Pro Ala Arg Pro Ser Asp Tyr Phe Tyr Cys Trp Asn Thr Phe 
            180                 185                 190         


Val Glu Asn His Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu 
        195                 200                 205             


Asn Ser Val Arg Leu Ser Arg Arg Leu Arg Arg Ile Leu Leu Pro Leu 
    210                 215                 220                 


Tyr Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu 
225                 230                 235                 


<210>  97
<211>  429
<212>  PRT
<213>  Mus musculus

<400>  97

Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Arg Met Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Thr Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210>  98
<211>  429
<212>  PRT
<213>  Rattus norvegicus

<400>  98

Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Arg Tyr Ala Ile Asp Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Val 
            100                 105                 110         


Leu Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Ile Arg Asp Pro Glu Asn Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Lys Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Arg Arg Arg Val His Leu Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Gly Val Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Ile Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu His Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210>  99
<211>  370
<212>  PRT
<213>  Macaca mulatta

<400>  99

Met Val Glu Pro Met Asp Pro Arg Thr Phe Val Ser Asn Phe Asn Asn 
1               5                   10                  15      


Arg Pro Ile Leu Ser Gly Leu Asn Thr Val Trp Leu Cys Cys Glu Val 
            20                  25                  30          


Lys Thr Lys Asp Pro Ser Gly Pro Pro Leu Asp Ala Lys Ile Phe Gln 
        35                  40                  45              


Gly Lys Val Tyr Ser Lys Ala Lys Tyr His Pro Glu Met Arg Phe Leu 
    50                  55                  60                  


Arg Trp Phe His Lys Trp Arg Gln Leu His His Asp Gln Glu Tyr Lys 
65                  70                  75                  80  


Val Thr Trp Tyr Val Ser Trp Ser Pro Cys Thr Arg Cys Ala Asn Ser 
                85                  90                  95      


Val Ala Thr Phe Leu Ala Lys Asp Pro Lys Val Thr Leu Thr Ile Phe 
            100                 105                 110         


Val Ala Arg Leu Tyr Tyr Phe Trp Lys Pro Asp Tyr Gln Gln Ala Leu 
        115                 120                 125             


Arg Ile Leu Cys Gln Lys Arg Gly Gly Pro His Ala Thr Met Lys Ile 
    130                 135                 140                 


Met Asn Tyr Asn Glu Phe Gln Asp Cys Trp Asn Lys Phe Val Asp Gly 
145                 150                 155                 160 


Arg Gly Lys Pro Phe Lys Pro Arg Asn Asn Leu Pro Lys His Tyr Thr 
                165                 170                 175     


Leu Leu Gln Ala Thr Leu Gly Glu Leu Leu Arg His Leu Met Asp Pro 
            180                 185                 190         


Gly Thr Phe Thr Ser Asn Phe Asn Asn Lys Pro Trp Val Ser Gly Gln 
        195                 200                 205             


His Glu Thr Tyr Leu Cys Tyr Lys Val Glu Arg Leu His Asn Asp Thr 
    210                 215                 220                 


Trp Val Pro Leu Asn Gln His Arg Gly Phe Leu Arg Asn Gln Ala Pro 
225                 230                 235                 240 


Asn Ile His Gly Phe Pro Lys Gly Arg His Ala Glu Leu Cys Phe Leu 
                245                 250                 255     


Asp Leu Ile Pro Phe Trp Lys Leu Asp Gly Gln Gln Tyr Arg Val Thr 
            260                 265                 270         


Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu Met Ala 
        275                 280                 285             


Lys Phe Ile Ser Asn Asn Glu His Val Ser Leu Cys Ile Phe Ala Ala 
    290                 295                 300                 


Arg Ile Tyr Asp Asp Gln Gly Arg Tyr Gln Glu Gly Leu Arg Ala Leu 
305                 310                 315                 320 


His Arg Asp Gly Ala Lys Ile Ala Met Met Asn Tyr Ser Glu Phe Glu 
                325                 330                 335     


Tyr Cys Trp Asp Thr Phe Val Asp Arg Gln Gly Arg Pro Phe Gln Pro 
            340                 345                 350         


Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg 
        355                 360                 365             


Ala Ile 
    370 


<210>  100
<211>  384
<212>  PRT
<213>  Pan troglodytes

<400>  100

Met Lys Pro His Phe Arg Asn Pro Val Glu Arg Met Tyr Gln Asp Thr 
1               5                   10                  15      


Phe Ser Asp Asn Phe Tyr Asn Arg Pro Ile Leu Ser His Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Lys Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Glu Leu Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Leu His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu His Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Asn Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Lys Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser 
        355                 360                 365             


Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380                 


<210>  101
<211>  377
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  101

Met Asn Pro Gln Ile Arg Asn Met Val Glu Gln Met Glu Pro Asp Ile 
1               5                   10                  15      


Phe Val Tyr Tyr Phe Asn Asn Arg Pro Ile Leu Ser Gly Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Asp Pro Ser Gly Pro Pro 
        35                  40                  45              


Leu Asp Ala Asn Ile Phe Gln Gly Lys Leu Tyr Pro Glu Ala Lys Asp 
    50                  55                  60                  


His Pro Glu Met Lys Phe Leu His Trp Phe Arg Lys Trp Arg Gln Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Val Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Arg Cys Ala Asn Ser Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Lys 
        115                 120                 125             


Pro Asp Tyr Gln Gln Ala Leu Arg Ile Leu Cys Gln Glu Arg Gly Gly 
    130                 135                 140                 


Pro His Ala Thr Met Lys Ile Met Asn Tyr Asn Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Asn Glu Phe Val Asp Gly Gln Gly Lys Pro Phe Lys Pro Arg Lys 
                165                 170                 175     


Asn Leu Pro Lys His Tyr Thr Leu Leu His Ala Thr Leu Gly Glu Leu 
            180                 185                 190         


Leu Arg His Val Met Asp Pro Gly Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Lys Pro Trp Val Ser Gly Gln Arg Glu Thr Tyr Leu Cys Tyr Lys Val 
    210                 215                 220                 


Glu Arg Ser His Asn Asp Thr Trp Val Leu Leu Asn Gln His Arg Gly 
225                 230                 235                 240 


Phe Leu Arg Asn Gln Ala Pro Asp Arg His Gly Phe Pro Lys Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Leu Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Asp Gln Gln Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe 
        275                 280                 285             


Ser Cys Ala Gln Lys Met Ala Lys Phe Ile Ser Asn Asn Lys His Val 
    290                 295                 300                 


Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys 
305                 310                 315                 320 


Gln Glu Gly Leu Arg Thr Leu His Arg Asp Gly Ala Lys Ile Ala Val 
                325                 330                 335     


Met Asn Tyr Ser Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Asp Arg 
            340                 345                 350         


Gln Gly Arg Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
        355                 360                 365             


Ala Leu Ser Gly Arg Leu Arg Ala Ile 
    370                 375         


<210>  102
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  102

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210>  103
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  103

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu 
    370             


<210>  104
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  104

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380         


<210>  105
<211>  396
<212>  PRT
<213>  Rattus norvegicus

<400>  105

Met Gln Pro Gln Gly Leu Gly Pro Asn Ala Gly Met Gly Pro Val Cys 
1               5                   10                  15      


Leu Gly Cys Ser His Arg Arg Pro Tyr Ser Pro Ile Arg Asn Pro Leu 
            20                  25                  30          


Lys Lys Leu Tyr Gln Gln Thr Phe Tyr Phe His Phe Lys Asn Val Arg 
        35                  40                  45              


Tyr Ala Trp Gly Arg Lys Asn Asn Phe Leu Cys Tyr Glu Val Asn Gly 
    50                  55                  60                  


Met Asp Cys Ala Leu Pro Val Pro Leu Arg Gln Gly Val Phe Arg Lys 
65                  70                  75                  80  


Gln Gly His Ile His Ala Glu Leu Cys Phe Ile Tyr Trp Phe His Asp 
                85                  90                  95      


Lys Val Leu Arg Val Leu Ser Pro Met Glu Glu Phe Lys Val Thr Trp 
            100                 105                 110         


Tyr Met Ser Trp Ser Pro Cys Ser Lys Cys Ala Glu Gln Val Ala Arg 
        115                 120                 125             


Phe Leu Ala Ala His Arg Asn Leu Ser Leu Ala Ile Phe Ser Ser Arg 
    130                 135                 140                 


Leu Tyr Tyr Tyr Leu Arg Asn Pro Asn Tyr Gln Gln Lys Leu Cys Arg 
145                 150                 155                 160 


Leu Ile Gln Glu Gly Val His Val Ala Ala Met Asp Leu Pro Glu Phe 
                165                 170                 175     


Lys Lys Cys Trp Asn Lys Phe Val Asp Asn Asp Gly Gln Pro Phe Arg 
            180                 185                 190         


Pro Trp Met Arg Leu Arg Ile Asn Phe Ser Phe Tyr Asp Cys Lys Leu 
        195                 200                 205             


Gln Glu Ile Phe Ser Arg Met Asn Leu Leu Arg Glu Asp Val Phe Tyr 
    210                 215                 220                 


Leu Gln Phe Asn Asn Ser His Arg Val Lys Pro Val Gln Asn Arg Tyr 
225                 230                 235                 240 


Tyr Arg Arg Lys Ser Tyr Leu Cys Tyr Gln Leu Glu Arg Ala Asn Gly 
                245                 250                 255     


Gln Glu Pro Leu Lys Gly Tyr Leu Leu Tyr Lys Lys Gly Glu Gln His 
            260                 265                 270         


Val Glu Ile Leu Phe Leu Glu Lys Met Arg Ser Met Glu Leu Ser Gln 
        275                 280                 285             


Val Arg Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
    290                 295                 300                 


Arg Gln Leu Ala Ala Phe Lys Lys Asp His Pro Asp Leu Ile Leu Arg 
305                 310                 315                 320 


Ile Tyr Thr Ser Arg Leu Tyr Phe Tyr Trp Arg Lys Lys Phe Gln Lys 
                325                 330                 335     


Gly Leu Cys Thr Leu Trp Arg Ser Gly Ile His Val Asp Val Met Asp 
            340                 345                 350         


Leu Pro Gln Phe Ala Asp Cys Trp Thr Asn Phe Val Asn Pro Gln Arg 
        355                 360                 365             


Pro Phe Arg Pro Trp Asn Glu Leu Glu Lys Asn Ser Trp Arg Ile Gln 
    370                 375                 380                 


Arg Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu 
385                 390                 395     


<210>  106
<211>  227
<212>  PRT
<213>  Bos taurus

<400>  106

Asp Gly Trp Glu Val Ala Phe Arg Ser Gly Thr Val Leu Lys Ala Gly 
1               5                   10                  15      


Val Leu Gly Val Ser Met Thr Glu Gly Trp Ala Gly Ser Gly His Pro 
            20                  25                  30          


Gly Gln Gly Ala Cys Val Trp Thr Pro Gly Thr Arg Asn Thr Met Asn 
        35                  40                  45              


Leu Leu Arg Glu Val Leu Phe Lys Gln Gln Phe Gly Asn Gln Pro Arg 
    50                  55                  60                  


Val Pro Ala Pro Tyr Tyr Arg Arg Lys Thr Tyr Leu Cys Tyr Gln Leu 
65                  70                  75                  80  


Lys Gln Arg Asn Asp Leu Thr Leu Asp Arg Gly Cys Phe Arg Asn Lys 
                85                  90                  95      


Lys Gln Arg His Ala Glu Ile Arg Phe Ile Asp Lys Ile Asn Ser Leu 
            100                 105                 110         


Asp Leu Asn Pro Ser Gln Ser Tyr Lys Ile Ile Cys Tyr Ile Thr Trp 
        115                 120                 125             


Ser Pro Cys Pro Asn Cys Ala Asn Glu Leu Val Asn Phe Ile Thr Arg 
    130                 135                 140                 


Asn Asn His Leu Lys Leu Glu Ile Phe Ala Ser Arg Leu Tyr Phe His 
145                 150                 155                 160 


Trp Ile Lys Ser Phe Lys Met Gly Leu Gln Asp Leu Gln Asn Ala Gly 
                165                 170                 175     


Ile Ser Val Ala Val Met Thr His Thr Glu Phe Glu Asp Cys Trp Glu 
            180                 185                 190         


Gln Phe Val Asp Asn Gln Ser Arg Pro Phe Gln Pro Trp Asp Lys Leu 
        195                 200                 205             


Glu Gln Tyr Ser Ala Ser Ile Arg Arg Arg Leu Gln Arg Ile Leu Thr 
    210                 215                 220                 


Ala Pro Ile 
225         


<210>  107
<211>  490
<212>  PRT
<213>  Pan troglodytes

<400>  107

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Trp Met Tyr Gln Arg Thr 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Arg Arg Gly His Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Met Tyr Ser Gln Pro Glu 
    50                  55                  60                  


His His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Ser Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Lys Phe Leu Ala Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Ile Arg His Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg His Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Gln Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Val Arg Ala Ser Ser Leu 
    370                 375                 380                 


Cys Met Val Pro His Arg Pro Pro Pro Pro Pro Gln Ser Pro Gly Pro 
385                 390                 395                 400 


Cys Leu Pro Leu Cys Ser Glu Pro Pro Leu Gly Ser Leu Leu Pro Thr 
                405                 410                 415     


Gly Arg Pro Ala Pro Ser Leu Pro Phe Leu Leu Thr Ala Ser Phe Ser 
            420                 425                 430         


Phe Pro Pro Pro Ala Ser Leu Pro Pro Leu Pro Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly His Leu Pro Val Pro Ser Phe His Ser Leu Thr Ser Cys Ser 
    450                 455                 460                 


Ile Gln Pro Pro Cys Ser Ser Arg Ile Arg Glu Thr Glu Gly Trp Ala 
465                 470                 475                 480 


Ser Val Ser Lys Glu Gly Arg Asp Leu Gly 
                485                 490 


<210>  108
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  108

Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr 
        115                 120                 125             


Pro Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 
                165                 170                 175     


Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 
            180                 185                 190 


<210>  109
<211>  190
<212>  PRT
<213>  Gorilla beringei

<400>  109

Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Asn Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Asp 
        115                 120                 125             


Thr Asp Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Lys Ile Met Asp Tyr Lys Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asp Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Tyr 
                165                 170                 175     


Asn Phe Arg Phe Leu Lys Arg Arg Leu Gln Glu Ile Leu Glu 
            180                 185                 190 


<210>  110
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  110

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  111
<211>  202
<212>  PRT
<213>  Macaca mulatta

<400>  111

Met Asp Gly Ser Pro Ala Ser Arg Pro Arg His Leu Met Asp Pro Asn 
1               5                   10                  15      


Thr Phe Thr Phe Asn Phe Asn Asn Asp Leu Ser Val Arg Gly Arg His 
            20                  25                  30          


Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Trp 
        35                  40                  45              


Val Pro Met Asp Glu Arg Arg Gly Phe Leu Cys Asn Lys Ala Lys Asn 
    50                  55                  60                  


Val Pro Cys Gly Asp Tyr Gly Cys His Val Glu Leu Arg Phe Leu Cys 
65                  70                  75                  80  


Glu Val Pro Ser Trp Gln Leu Asp Pro Ala Gln Thr Tyr Arg Val Thr 
                85                  90                  95      


Trp Phe Ile Ser Trp Ser Pro Cys Phe Arg Arg Gly Cys Ala Gly Gln 
            100                 105                 110         


Val Arg Val Phe Leu Gln Glu Asn Lys His Val Arg Leu Arg Ile Phe 
        115                 120                 125             


Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Gln Glu Ala Leu Arg 
    130                 135                 140                 


Thr Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Glu Glu 
145                 150                 155                 160 


Phe Lys His Cys Trp Asp Thr Phe Val Asp Arg Gln Gly Arg Pro Phe 
                165                 170                 175     


Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg 
            180                 185                 190         


Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
        195                 200         


<210>  112
<211>  185
<212>  PRT
<213>  Bos taurus

<400>  112

Met Asp Glu Tyr Thr Phe Thr Glu Asn Phe Asn Asn Gln Gly Trp Pro 
1               5                   10                  15      


Ser Lys Thr Tyr Leu Cys Tyr Glu Met Glu Arg Leu Asp Gly Asp Ala 
            20                  25                  30          


Thr Ile Pro Leu Asp Glu Tyr Lys Gly Phe Val Arg Asn Lys Gly Leu 
        35                  40                  45              


Asp Gln Pro Glu Lys Pro Cys His Ala Glu Leu Tyr Phe Leu Gly Lys 
    50                  55                  60                  


Ile His Ser Trp Asn Leu Asp Arg Asn Gln His Tyr Arg Leu Thr Cys 
65                  70                  75                  80  


Phe Ile Ser Trp Ser Pro Cys Tyr Asp Cys Ala Gln Lys Leu Thr Thr 
                85                  90                  95      


Phe Leu Lys Glu Asn His His Ile Ser Leu His Ile Leu Ala Ser Arg 
            100                 105                 110         


Ile Tyr Thr His Asn Arg Phe Gly Cys His Gln Ser Gly Leu Cys Glu 
        115                 120                 125             


Leu Gln Ala Ala Gly Ala Arg Ile Thr Ile Met Thr Phe Glu Asp Phe 
    130                 135                 140                 


Lys His Cys Trp Glu Thr Phe Val Asp His Lys Gly Lys Pro Phe Gln 
145                 150                 155                 160 


Pro Trp Glu Gly Leu Asn Val Lys Ser Gln Ala Leu Cys Thr Glu Leu 
                165                 170                 175     


Gln Ala Ile Leu Lys Thr Gln Gln Asn 
            180                 185 


<210>  113
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  113

Met Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 
        35                  40                  45              


Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Phe Pro Lys Phe Ala Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 
145                 150                 155                 160 


Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met 
            180                 185                 190         


Asp Ile Leu Cys Asp Ala Glu Val 
        195                 200 


<210>  114
<211>  210
<212>  PRT
<213>  Macaca mulatta

<400>  114

Met Ala Leu Leu Thr Ala Lys Thr Phe Ser Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Val Asn Lys Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly His Leu Lys 
        35                  40                  45              


Asn Lys Lys Lys Asp His Ala Glu Ile Arg Phe Ile Asn Lys Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Pro Ser Cys Ala Gly Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Arg His Leu Asn Leu Arg Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Arg Pro Asn Tyr Gln Glu Gly Leu Leu Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Leu Pro Glu Phe Thr Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Lys Glu Pro Pro Ser Phe Asn Pro Ser 
145                 150                 155                 160 


Glu Lys Leu Glu Glu Leu Asp Lys Asn Ser Gln Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ser Arg Ser Val Asp Val Leu Glu Asn Gly Leu 
            180                 185                 190         


Arg Ser Leu Gln Leu Gly Pro Val Thr Pro Ser Ser Ser Ile Arg Asn 
        195                 200                 205             


Ser Arg 
    210 


<210>  115
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  115

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln 
    50                  55                  60                  


Ser Asn His Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His Ala Glu 
65                  70                  75                  80  


Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Arg Leu Pro Ala Asn Arg 
                85                  90                  95      


Arg Phe Gln Ile Thr Trp Phe Val Ser Trp Asn Pro Cys Leu Pro Cys 
            100                 105                 110         


Val Val Lys Val Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu 
        115                 120                 125             


Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg 
    130                 135                 140                 


Trp Val Leu Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met 
145                 150                 155                 160 


Asp Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu 
                165                 170                 175     


Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser 
            180                 185                 190         


Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met 
        195                 200                 205             


Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Leu Lys Ala Cys 
    210                 215                 220                 


Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val Thr Lys His 
225                 230                 235                 240 


His Ser Ala Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp 
                245                 250                 255     


Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 
            260                 265                 270         


Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr 
        275                 280                 285             


Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu 
    290                 295                 300                 


Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys 
305                 310                 315                 320 


Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser Leu Ser Gln 
                325                 330                 335     


Glu Gly Ala Ser Val Lys Ile Met Gly Tyr Lys Asp Phe Val Ser Cys 
            340                 345                 350         


Trp Lys Asn Phe Val Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys 
        355                 360                 365             


Gly Leu Gln Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile 
    370                 375                 380                 


Leu Gln 
385     


<210>  116
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  116

Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg 
225                 230                 235     


<210>  117
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  117

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Val Trp Arg His Thr Ser Gln Asn Thr Ser Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg Tyr Phe Arg Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg His Pro Tyr Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Thr Asp Gln Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Ser Asn Glu Ala Tyr Trp Pro Arg Tyr Pro His Leu Trp Val Lys 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Thr Leu Gln Thr Cys His Tyr Gln Arg Ile Pro Pro His Leu Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  118
<211>  229
<212>  PRT
<213>  Rattus norvegicus

<400>  118

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  119
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  119

Met Ala Gln Lys Glu Glu Ala Ala Val Ala Thr Glu Ala Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Asp Leu Glu Asn Leu Asp Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Gly Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Ala 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Ile Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Ile Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Val Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Gln Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210>  120
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  120

Met Ala Gln Lys Glu Glu Ala Ala Glu Ala Ala Ala Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Asp Asp Leu Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Asp Leu Pro Pro Phe Glu Ile Val Thr Gly Val Arg Leu Pro 
        35                  40                  45              


Val Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Val Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Ala Gln Ala Thr Gln Gly Tyr Leu Glu Asp Glu His Ala Gly 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Lys Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Leu Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Ser Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Val Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Ile Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210>  121
<211>  224
<212>  PRT
<213>  Rattus norvegicus

<400>  121

Met Ala Gln Lys Glu Glu Ala Ala Glu Ala Ala Ala Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Asp Asp Leu Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Asp Leu Pro Pro Phe Glu Ile Val Thr Gly Val Arg Leu Pro 
        35                  40                  45              


Val Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Thr Gln Gly Tyr Leu Glu Asp Glu His Ala Gly 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Lys Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Leu Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Ser Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Val Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Leu Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210>  122
<211>  224
<212>  PRT
<213>  Bos taurus

<400>  122

Met Ala Gln Lys Glu Glu Ala Ala Ala Ala Ala Glu Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Glu Val Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala His Tyr Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Thr 
                85                  90                  95      


Asn His Ala Glu Glu Ala Phe Phe Asn Ser Ile Met Pro Thr Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Met Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Val Lys Thr Leu Asn Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Ile Gln Ala Ala Leu Arg Lys Leu Lys Glu Ala Gly Cys Arg Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Ile Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210>  123
<211>  208
<212>  PRT
<213>  Petromyzon marinus

<400>  123

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210>  124
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  124

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210>  125
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  125

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln 
            180                 


<210>  126
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  126

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln 
            180                 


<210>  127
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127

Met Phe Glu Arg Asn Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Tyr 
1               5                   10                  15      


Leu Leu Tyr Glu Ile Lys Trp Gly Lys Ser Gly Lys Leu Trp Arg His 
            20                  25                  30          


Trp Cys Gln Asn Asn Arg Thr Gln His Ala Glu Val Tyr Phe Leu Glu 
        35                  40                  45              


Asn Ile Phe Asn Ala Arg Arg Phe Asn Pro Ser Thr His Cys Ser Ile 
    50                  55                  60                  


Thr Trp Tyr Leu Ser Trp Ser Pro Cys Ala Glu Cys Ser Gln Lys Ile 
65                  70                  75                  80  


Val Asp Phe Leu Lys Glu His Pro Asn Val Asn Leu Glu Ile Tyr Val 
                85                  90                  95      


Ala Arg Leu Tyr Tyr His Glu Asp Glu Arg Asn Arg Gln Gly Leu Arg 
            100                 105                 110         


Asp Leu Val Asn Ser Gly Val Thr Ile Arg Ile Met Asp Leu Pro Asp 
        115                 120                 125             


Tyr Asn Tyr Cys Trp Lys Thr Phe Val Ser Asp Gln Gly Gly Asp Glu 
    130                 135                 140                 


Asp Tyr Trp Pro Gly His Phe Ala Pro Trp Ile Lys Gln Tyr Ser Leu 
145                 150                 155                 160 


Lys Leu 
        


<210>  128
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128

Met Phe Glu Arg Asn Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Tyr 
1               5                   10                  15      


Leu Leu Tyr Glu Ile Lys Trp Gly Lys Ser Gly Lys Leu Trp Arg His 
            20                  25                  30          


Trp Cys Gln Asn Asn Arg Thr Gln His Ala Glu Val Tyr Phe Leu Glu 
        35                  40                  45              


Asn Ile Phe Asn Ala Arg Arg Phe Asn Pro Ser Thr His Cys Ser Ile 
    50                  55                  60                  


Thr Trp Tyr Leu Ser Trp Ser Pro Cys Ala Glu Cys Ser Gln Lys Ile 
65                  70                  75                  80  


Val Asp Phe Leu Lys Glu His Pro Asn Val Asn Leu Glu Ile Tyr Val 
                85                  90                  95      


Ala Arg Leu Tyr Tyr Pro Glu Asn Glu Arg Asn Arg Gln Gly Leu Arg 
            100                 105                 110         


Asp Leu Val Asn Ser Gly Val Thr Ile Arg Ile Met Asp Leu Pro Asp 
        115                 120                 125             


Tyr Asn Tyr Cys Trp Lys Thr Phe Val Ser Asp Gln Gly Gly Asp Glu 
    130                 135                 140                 


Asp Tyr Trp Pro Gly His Phe Ala Pro Trp Ile Lys Gln Tyr Ser Leu 
145                 150                 155                 160 


Lys Leu 
        


<210>  129
<211>  229
<212>  PRT
<213>  Rattus norvegicus

<400>  129

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  130
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130

Met Ser Ser Lys Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro Asn Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His Leu Ala Asn Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp His Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ser His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Ser Gln Leu Thr Ser Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  131
<211>  208
<212>  PRT
<213>  Petromyzon marinus

<400>  131

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210>  132
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Ser Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Val Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Phe Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210>  133
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Thr Ser His 
        35                  40                  45              


Lys Ile Trp Arg His Ser Ser Lys Asn Thr Thr Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Ser Glu Arg His Phe Cys Pro Ser Thr 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Lys Ala Ile Thr Glu Phe Leu Ser Gln His Pro Asn Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Tyr His His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Ala Pro Glu Tyr Asp Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Lys Glu Ala His Trp Pro Arg Tyr Pro Pro Leu Trp Met Lys 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Ala Gly Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  134
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134

Met Ser Ser Lys Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Thr Ser His 
        35                  40                  45              


Lys Ile Trp Arg His Ser Ser Lys Asn Thr Thr Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Ser Glu Arg His Phe Cys Pro Ser Thr 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Lys Ala Ile Thr Glu Phe Leu Ser Gln His Pro Asn Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Tyr His Leu Met Asn Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Ala Pro Glu Tyr Asp Tyr Cys Trp His Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Lys Glu Ser His Trp Pro Arg Tyr Pro Pro Leu Trp Met Lys 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Ala Gly Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Ser Gln Leu Thr Ser Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  135
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(1)

<400>  135

Gly 
1   


<210>  136
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(2)

<400>  136

Xaa Pro 
1       


<210>  137
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(3)

<400>  137

Gly Gly Ser 
1           


<210>  138
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(4)

<400>  138

Ser Gly Gly Ser 
1               


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(4)

<400>  139

Ser Gly Gly Ser 
1               


<210>  140
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(4)

<400>  140

Gly Gly Gly Ser 
1               


<210>  141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(5)

<400>  141

Gly Gly Gly Gly Ser 
1               5   


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(5)

<400>  142

Glu Ala Ala Ala Lys 
1               5   


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  144
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  145
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(4)

<220>
<221>  REPEAT
<222>  (21)..(24)

<400>  145

Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
1               5                   10                  15      


Thr Pro Glu Ser Ser Gly Gly Ser 
            20                  


<210>  146
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser 
            20                  


<210>  147
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  148
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser 
        35                  40  


<210>  149
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
        35                  40                  45              


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    50                  55                  60                  


<210>  150
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150

Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30          


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        35                  40                  45              


Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
    50                  55                  60                  


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
65                  70                  75                  80  


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
                85                  90          


<210>  151
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151

Gly Gly Ser Gly Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
1               5                   10                  15      


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  25                  30          


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
        35                  40                  45              


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
    50                  55                  60                  


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70                  75                  80  


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
                85                  90                  95      


Thr Ser Gly Gly Ser Gly Gly Ser 
            100                 


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156

Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg 
1               5                   10  


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157

Pro Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu 
1               5                   10          


<210>  158
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val 
            


<210>  159
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  159

Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Asp 
            20  


<210>  160
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160

Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  161
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  162
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210>  163
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163

Met Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu 
1               5                   10                  15      


Val Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val 
            20                  25                  30          


Ile Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp 
        35                  40                  45              


Glu Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu 
    50                  55                  60                  


Tyr Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys 
65                  70                  75                  80  


Ile Lys Met Leu 
                


<210>  164
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  165
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Val Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Thr Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  166
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  166

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Pro Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  167
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  167

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  168
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  168

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Pro Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  169
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  169

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asn Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  170
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  170

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  171
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  171

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Val Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  172
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  172
gccaacatga ggatcaccca tgtctgcagg gcc                                    33


<210>  173
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  173

Gly Ser Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly 
1               5                   10                  15      


Thr Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala 
            20                  25                  30          


Glu Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys 
        35                  40                  45              


Ser Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val 
    50                  55                  60                  


Glu Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Glu Glu Leu Pro 
65                  70                  75                  80  


Val Ala Gly Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile 
                85                  90                  95      


Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly 
            100                 105                 110         


Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser 
        115                 120                 125             


Gly Ile Tyr 
    130     


<210>  174
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  174

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  175
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  175

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  176
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  176

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  177
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  177

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  178
<211>  1550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  178

Met Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  
    1550 


<210>  179
<211>  1550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa can be any naturally occurring amino acid

<400>  179

Met Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Xaa Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  
    1550 


<210>  180
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  180

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  181
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  181

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  182
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  182

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Ser Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  183
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  183

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Pro Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  184
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  184

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Pro Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  185
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  185

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  186
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  186

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  187
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  187

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  188
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  188

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  189
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  189

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  190
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  190

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  191
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  191

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  192
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  192

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  193
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  193

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  194
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  194

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  195
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  195

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  196
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  196

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  197
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  197

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  198
<211>  1776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  198

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  Cys 
    1775     


<210>  199
<211>  1773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  199

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Gly Glu Gly 
225                 230                 235                 240 


Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile 
                245                 250                 255     


Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile 
            260                 265                 270         


Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly 
        275                 280                 285             


Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn 
    290                 295                 300                 


Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro 
305                 310                 315                 320 


Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu 
                325                 330                 335     


Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe 
            340                 345                 350         


Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser 
        355                 360                 365             


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
    370                 375                 380                 


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
385                 390                 395                 400 


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
                405                 410                 415     


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
            420                 425                 430         


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
        435                 440                 445             


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
    450                 455                 460                 


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
465                 470                 475                 480 


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
                485                 490                 495     


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
            500                 505                 510         


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
        515                 520                 525             


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
    530                 535                 540                 


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
545                 550                 555                 560 


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
                565                 570                 575     


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
            580                 585                 590         


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
        595                 600                 605             


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
    610                 615                 620                 


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
625                 630                 635                 640 


Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala 
                645                 650                 655     


Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu 
            660                 665                 670         


Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys 
        675                 680                 685             


Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr 
    690                 695                 700                 


Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp 
705                 710                 715                 720 


Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln 
                725                 730                 735     


Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly 
            740                 745                 750         


Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys 
        755                 760                 765             


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu 
    770                 775                 780                 


Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
785                 790                 795                 800 


Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile 
                805                 810                 815     


Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu 
            820                 825                 830         


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
        835                 840                 845             


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu 
    850                 855                 860                 


Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
865                 870                 875                 880 


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu 
                885                 890                 895     


Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
            900                 905                 910         


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met 
        915                 920                 925             


Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
    930                 935                 940                 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
945                 950                 955                 960 


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly 
                965                 970                 975     


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
            980                 985                 990         


Lys Ile Ile Lys Asp Lys Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp 
        995                 1000                 1005             


Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg 
    1010                 1015                 1020             


Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp 
    1025                 1030                 1035             


Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp 
    1040                 1045                 1050             


Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
    1055                 1060                 1065             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1070                 1075                 1080             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1085                 1090                 1095             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1100                 1105                 1110             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1115                 1120                 1125             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1130                 1135                 1140             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1145                 1150                 1155             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1160                 1165                 1170             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1175                 1180                 1185             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1190                 1195                 1200             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1205                 1210                 1215             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1220                 1225                 1230             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1235                 1240                 1245             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1250                 1255                 1260             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1265                 1270                 1275             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1280                 1285                 1290             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1295                 1300                 1305             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1310                 1315                 1320             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1325                 1330                 1335             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1340                 1345                 1350             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1355                 1360                 1365             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1370                 1375                 1380             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1385                 1390                 1395             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1400                 1405                 1410             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1415                 1420                 1425             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1430                 1435                 1440             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1445                 1450                 1455             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1460                 1465                 1470             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1475                 1480                 1485             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1490                 1495                 1500             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1505                 1510                 1515             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1520                 1525                 1530             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1535                 1540                 1545             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1550                 1555                 1560             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1565                 1570                 1575             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1580                 1585                 1590             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1595                 1600                 1605             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1610                 1615                 1620             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1625                 1630                 1635             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1640                 1645                 1650             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1655                 1660                 1665             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1670                 1675                 1680             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1685                 1690                 1695             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1700                 1705                 1710             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1715                 1720                 1725             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1730                 1735                 1740             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1745                 1750                 1755             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1760                 1765                 1770             


<210>  200
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  200

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  201
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  201

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Gln Tyr  Arg Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  202
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  202

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  203
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  203

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  204
<211>  1291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  204

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu 
    210                 215                 220                 


Gly Leu Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr 
225                 230                 235                 240 


Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala 
                245                 250                 255     


Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg 
            260                 265                 270         


Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu 
        275                 280                 285             


Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn 
    290                 295                 300                 


Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu 
305                 310                 315                 320 


Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His 
                325                 330                 335     


Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys 
            340                 345                 350         


Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala 
        355                 360                 365             


Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser 
    370                 375                 380                 


Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu 
385                 390                 395                 400 


Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp 
                405                 410                 415     


Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro 
            420                 425                 430         


Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu 
        435                 440                 445             


Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val 
    450                 455                 460                 


Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn 
465                 470                 475                 480 


Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu 
                485                 490                 495     


Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr 
            500                 505                 510         


Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys 
        515                 520                 525             


Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys 
    530                 535                 540                 


Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu 
545                 550                 555                 560 


Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln 
                565                 570                 575     


Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu 
            580                 585                 590         


Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly 
        595                 600                 605             


Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu 
    610                 615                 620                 


Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu 
625                 630                 635                 640 


Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr 
                645                 650                 655     


Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile 
            660                 665                 670         


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro 
        675                 680                 685             


Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala 
    690                 695                 700                 


Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu 
705                 710                 715                 720 


Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr 
                725                 730                 735     


Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu 
            740                 745                 750         


Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe 
        755                 760                 765             


Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn 
    770                 775                 780                 


Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys 
785                 790                 795                 800 


Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile 
                805                 810                 815     


Ser Tyr Glu Thr Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys 
            820                 825                 830         


Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp 
        835                 840                 845             


Ile Asn Arg Phe Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val 
    850                 855                 860                 


Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr 
865                 870                 875                 880 


Phe Arg Val Asn Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly 
                885                 890                 895     


Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn 
            900                 905                 910         


Lys Gly Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala 
        915                 920                 925             


Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val 
    930                 935                 940                 


Met Glu Asn Gln Met Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu 
945                 950                 955                 960 


Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile Phe Ile Thr Pro His Gln 
                965                 970                 975     


Ile Lys His Ile Lys Asp Phe Lys Asp Tyr Lys Tyr Ser His Arg Val 
            980                 985                 990         


Asp Lys Lys Pro Asn Arg Glu Leu  Ile Asn Asp Thr Leu  Tyr Ser Thr 
        995                 1000                 1005             


Arg Lys  Asp Asp Lys Gly Asn  Thr Leu Ile Val Asn  Asn Leu Asn 
    1010                 1015                 1020             


Gly Leu  Tyr Asp Lys Asp Asn  Asp Lys Leu Lys Lys  Leu Ile Asn 
    1025                 1030                 1035             


Lys Ser  Pro Glu Lys Leu Leu  Met Tyr His His Asp  Pro Gln Thr 
    1040                 1045                 1050             


Tyr Gln  Lys Leu Lys Leu Ile  Met Glu Gln Tyr Gly  Asp Glu Lys 
    1055                 1060                 1065             


Asn Pro  Leu Tyr Lys Tyr Tyr  Glu Glu Thr Gly Asn  Tyr Leu Thr 
    1070                 1075                 1080             


Lys Tyr  Ser Lys Lys Asp Asn  Gly Pro Val Ile Lys  Lys Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Gly Asn Lys Leu Asn  Ala His Leu Asp Ile  Thr Asp Asp 
    1100                 1105                 1110             


Tyr Pro  Asn Ser Arg Asn Lys  Val Val Lys Leu Ser  Leu Lys Pro 
    1115                 1120                 1125             


Tyr Arg  Phe Asp Val Tyr Leu  Asp Asn Gly Val Tyr  Lys Phe Val 
    1130                 1135                 1140             


Thr Val  Lys Asn Leu Asp Val  Ile Lys Lys Glu Asn  Tyr Tyr Glu 
    1145                 1150                 1155             


Val Asn  Ser Lys Cys Tyr Glu  Glu Ala Lys Lys Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ser Asn  Gln Ala Glu Phe Ile  Ala Ser Phe Tyr Asn  Asn Asp Leu 
    1175                 1180                 1185             


Ile Lys  Ile Asn Gly Glu Leu  Tyr Arg Val Ile Gly  Val Asn Asn 
    1190                 1195                 1200             


Asp Leu  Leu Asn Arg Ile Glu  Val Asn Met Ile Asp  Ile Thr Tyr 
    1205                 1210                 1215             


Arg Glu  Tyr Leu Glu Asn Met  Asn Asp Lys Arg Pro  Pro Arg Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Ala Ser Lys  Thr Gln Ser Ile Lys  Lys Tyr Ser 
    1235                 1240                 1245             


Thr Asp  Ile Leu Gly Asn Leu  Tyr Glu Val Lys Ser  Lys Lys His 
    1250                 1255                 1260             


Pro Gln  Ile Ile Lys Lys Gly  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1265                 1270                 1275             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1280                 1285                 1290     


<210>  205
<211>  1489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  205

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly 
                405                 410                 415     


Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val Gly 
            420                 425                 430         


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
        435                 440                 445             


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
    450                 455                 460                 


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
465                 470                 475                 480 


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
                485                 490                 495     


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
            500                 505                 510         


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
        515                 520                 525             


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
    530                 535                 540                 


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
545                 550                 555                 560 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
                565                 570                 575     


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
            580                 585                 590         


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
        595                 600                 605             


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
    610                 615                 620                 


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
625                 630                 635                 640 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
                645                 650                 655     


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
            660                 665                 670         


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
        675                 680                 685             


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
    690                 695                 700                 


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
705                 710                 715                 720 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
                725                 730                 735     


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
            740                 745                 750         


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
        755                 760                 765             


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
    770                 775                 780                 


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
785                 790                 795                 800 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
                805                 810                 815     


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
            820                 825                 830         


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
        835                 840                 845             


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
    850                 855                 860                 


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
865                 870                 875                 880 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
                885                 890                 895     


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
            900                 905                 910         


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
        915                 920                 925             


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
    930                 935                 940                 


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
945                 950                 955                 960 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
                965                 970                 975     


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
            980                 985                 990         


Glu Glu Asn Ser Lys Lys Gly Asn  Arg Thr Pro Phe Gln  Tyr Leu Ser 
        995                 1000                 1005             


Ser Ser  Asp Ser Lys Ile Ser  Tyr Glu Thr Phe Lys  Lys His Ile 
    1010                 1015                 1020             


Leu Asn  Leu Ala Lys Gly Lys  Gly Arg Ile Ser Lys  Thr Lys Lys 
    1025                 1030                 1035             


Glu Tyr  Leu Leu Glu Glu Arg  Asp Ile Asn Arg Phe  Ser Val Gln 
    1040                 1045                 1050             


Lys Asp  Phe Ile Asn Arg Asn  Leu Val Asp Thr Arg  Tyr Ala Thr 
    1055                 1060                 1065             


Arg Gly  Leu Met Asn Leu Leu  Arg Ser Tyr Phe Arg  Val Asn Asn 
    1070                 1075                 1080             


Leu Asp  Val Lys Val Lys Ser  Ile Asn Gly Gly Phe  Thr Ser Phe 
    1085                 1090                 1095             


Leu Arg  Arg Lys Trp Lys Phe  Lys Lys Glu Arg Asn  Lys Gly Tyr 
    1100                 1105                 1110             


Lys His  His Ala Glu Asp Ala  Leu Ile Ile Ala Asn  Ala Asp Phe 
    1115                 1120                 1125             


Ile Phe  Lys Glu Trp Lys Lys  Leu Asp Lys Ala Lys  Lys Val Met 
    1130                 1135                 1140             


Glu Asn  Gln Met Phe Glu Glu  Lys Gln Ala Glu Ser  Met Pro Glu 
    1145                 1150                 1155             


Ile Glu  Thr Glu Gln Glu Tyr  Lys Glu Ile Phe Ile  Thr Pro His 
    1160                 1165                 1170             


Gln Ile  Lys His Ile Lys Asp  Phe Lys Asp Tyr Lys  Tyr Ser His 
    1175                 1180                 1185             


Arg Val  Asp Lys Lys Pro Asn  Arg Glu Leu Ile Asn  Asp Thr Leu 
    1190                 1195                 1200             


Tyr Ser  Thr Arg Lys Asp Asp  Lys Gly Asn Thr Leu  Ile Val Asn 
    1205                 1210                 1215             


Asn Leu  Asn Gly Leu Tyr Asp  Lys Asp Asn Asp Lys  Leu Lys Lys 
    1220                 1225                 1230             


Leu Ile  Asn Lys Ser Pro Glu  Lys Leu Leu Met Tyr  His His Asp 
    1235                 1240                 1245             


Pro Gln  Thr Tyr Gln Lys Leu  Lys Leu Ile Met Glu  Gln Tyr Gly 
    1250                 1255                 1260             


Asp Glu  Lys Asn Pro Leu Tyr  Lys Tyr Tyr Glu Glu  Thr Gly Asn 
    1265                 1270                 1275             


Tyr Leu  Thr Lys Tyr Ser Lys  Lys Asp Asn Gly Pro  Val Ile Lys 
    1280                 1285                 1290             


Lys Ile  Lys Tyr Tyr Gly Asn  Lys Leu Asn Ala His  Leu Asp Ile 
    1295                 1300                 1305             


Thr Asp  Asp Tyr Pro Asn Ser  Arg Asn Lys Val Val  Lys Leu Ser 
    1310                 1315                 1320             


Leu Lys  Pro Tyr Arg Phe Asp  Val Tyr Leu Asp Asn  Gly Val Tyr 
    1325                 1330                 1335             


Lys Phe  Val Thr Val Lys Asn  Leu Asp Val Ile Lys  Lys Glu Asn 
    1340                 1345                 1350             


Tyr Tyr  Glu Val Asn Ser Lys  Cys Tyr Glu Glu Ala  Lys Lys Leu 
    1355                 1360                 1365             


Lys Lys  Ile Ser Asn Gln Ala  Glu Phe Ile Ala Ser  Phe Tyr Asn 
    1370                 1375                 1380             


Asn Asp  Leu Ile Lys Ile Asn  Gly Glu Leu Tyr Arg  Val Ile Gly 
    1385                 1390                 1395             


Val Asn  Asn Asp Leu Leu Asn  Arg Ile Glu Val Asn  Met Ile Asp 
    1400                 1405                 1410             


Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met Asn Asp  Lys Arg Pro 
    1415                 1420                 1425             


Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys Thr Gln  Ser Ile Lys 
    1430                 1435                 1440             


Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu Tyr Glu  Val Lys Ser 
    1445                 1450                 1455             


Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly Ser Gly  Gly Ser Lys 
    1460                 1465                 1470             


Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys 
    1475                 1480                 1485             


Val 
    


<210>  206
<211>  1464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  206

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr 
    210                 215                 220                 


Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val 
225                 230                 235                 240 


Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp 
                245                 250                 255     


Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg 
            260                 265                 270         


Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys 
        275                 280                 285             


Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu 
    290                 295                 300                 


Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu 
305                 310                 315                 320 


Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys 
                325                 330                 335     


Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp 
            340                 345                 350         


Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr 
        355                 360                 365             


Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser 
    370                 375                 380                 


Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile 
385                 390                 395                 400 


Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His 
                405                 410                 415     


Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val 
            420                 425                 430         


Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu 
        435                 440                 445             


Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser 
    450                 455                 460                 


Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln 
465                 470                 475                 480 


Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val 
                485                 490                 495     


Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser 
            500                 505                 510         


Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser 
        515                 520                 525             


Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe 
    530                 535                 540                 


Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile 
545                 550                 555                 560 


Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp 
                565                 570                 575     


Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val 
            580                 585                 590         


Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile 
        595                 600                 605             


Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu 
    610                 615                 620                 


Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu 
625                 630                 635                 640 


Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe 
                645                 650                 655     


Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met 
            660                 665                 670         


Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala 
        675                 680                 685             


Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly 
    690                 695                 700                 


Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr 
705                 710                 715                 720 


Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys 
                725                 730                 735     


Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys 
            740                 745                 750         


Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys 
        755                 760                 765             


Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys 
    770                 775                 780                 


Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys 
785                 790                 795                 800 


Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys 
                805                 810                 815     


Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr 
            820                 825                 830         


Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys 
        835                 840                 845             


His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys 
    850                 855                 860                 


Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys 
865                 870                 875                 880 


Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val 
                885                 890                 895     


Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu 
            900                 905                 910         


Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys 
        915                 920                 925             


Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe 
    930                 935                 940                 


Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu 
945                 950                 955                 960 


Phe Met Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro 
                965                 970                 975     


Ala Asn Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr 
            980                 985                 990         


Thr Thr Leu Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
        995                 1000                 1005             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1010                 1015                 1020             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1025                 1030                 1035             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Ala Arg Gly  Glu Arg Asn 
    1040                 1045                 1050             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1055                 1060                 1065             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1070                 1075                 1080             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1085                 1090                 1095             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1100                 1105                 1110             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1115                 1120                 1125             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1130                 1135                 1140             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1145                 1150                 1155             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1160                 1165                 1170             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1175                 1180                 1185             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1190                 1195                 1200             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1205                 1210                 1215             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1220                 1225                 1230             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1235                 1240                 1245             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1250                 1255                 1260             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1265                 1270                 1275             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1280                 1285                 1290             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1295                 1300                 1305             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1310                 1315                 1320             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1325                 1330                 1335             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1340                 1345                 1350             


Arg Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1355                 1360                 1365             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1370                 1375                 1380             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1385                 1390                 1395             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1400                 1405                 1410             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1415                 1420                 1425             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1430                 1435                 1440             


Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro 
    1445                 1450                 1455             


Lys Lys  Lys Arg Lys Val 
    1460                 


<210>  207
<211>  1662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  207

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg 
            420                 425                 430         


Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys 
        435                 440                 445             


Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val 
    450                 455                 460                 


Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu 
465                 470                 475                 480 


His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg 
                485                 490                 495     


Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu 
            500                 505                 510         


Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly 
        515                 520                 525             


Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu 
    530                 535                 540                 


Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly 
545                 550                 555                 560 


Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe 
                565                 570                 575     


Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu 
            580                 585                 590         


Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp 
        595                 600                 605             


Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu 
    610                 615                 620                 


Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn 
625                 630                 635                 640 


Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly 
                645                 650                 655     


Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr 
            660                 665                 670         


Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys 
        675                 680                 685             


Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr 
    690                 695                 700                 


Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn 
705                 710                 715                 720 


Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu 
                725                 730                 735     


Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val 
            740                 745                 750         


Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu 
        755                 760                 765             


Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His 
    770                 775                 780                 


Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg 
785                 790                 795                 800 


Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu 
                805                 810                 815     


Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile 
            820                 825                 830         


Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys 
        835                 840                 845             


Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp 
    850                 855                 860                 


Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe 
865                 870                 875                 880 


Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg 
                885                 890                 895     


Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu 
            900                 905                 910         


Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys 
        915                 920                 925             


Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe 
    930                 935                 940                 


Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile 
945                 950                 955                 960 


Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr 
                965                 970                 975     


Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr 
            980                 985                 990         


Glu Lys Ile Asn Tyr Lys Leu Leu  Pro Gly Pro Asn Lys  Met Leu Pro 
        995                 1000                 1005             


Lys Val  Phe Phe Ser Lys Lys  Trp Met Ala Tyr Tyr  Asn Pro Ser 
    1010                 1015                 1020             


Glu Asp  Ile Gln Lys Ile Tyr  Lys Asn Gly Thr Phe  Lys Lys Gly 
    1025                 1030                 1035             


Asp Met  Phe Asn Leu Asn Asp  Cys His Lys Leu Ile  Asp Phe Phe 
    1040                 1045                 1050             


Lys Asp  Ser Ile Ser Arg Tyr  Pro Lys Trp Ser Asn  Ala Tyr Asp 
    1055                 1060                 1065             


Phe Asn  Phe Ser Glu Thr Glu  Lys Tyr Lys Asp Ile  Ala Gly Phe 
    1070                 1075                 1080             


Tyr Arg  Glu Val Glu Glu Gln  Gly Tyr Lys Val Ser  Phe Glu Ser 
    1085                 1090                 1095             


Ala Ser  Lys Lys Glu Val Asp  Lys Leu Val Glu Glu  Gly Lys Leu 
    1100                 1105                 1110             


Tyr Met  Phe Gln Ile Tyr Asn  Lys Asp Phe Ser Asp  Lys Ser His 
    1115                 1120                 1125             


Gly Thr  Pro Asn Leu His Thr  Met Tyr Phe Lys Leu  Leu Phe Asp 
    1130                 1135                 1140             


Glu Asn  Asn His Gly Gln Ile  Arg Leu Ser Gly Gly  Ala Glu Leu 
    1145                 1150                 1155             


Phe Met  Arg Arg Ala Ser Leu  Lys Lys Glu Glu Leu  Val Val His 
    1160                 1165                 1170             


Pro Ala  Asn Ser Pro Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys 
    1175                 1180                 1185             


Lys Thr  Thr Thr Leu Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe 
    1190                 1195                 1200             


Ser Glu  Asp Gln Tyr Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys 
    1205                 1210                 1215             


Cys Pro  Lys Asn Ile Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu 
    1220                 1225                 1230             


Leu Lys  His Asp Asp Asn Pro  Tyr Val Ile Gly Ile  Ala Arg Gly 
    1235                 1240                 1245             


Glu Arg  Asn Leu Leu Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn 
    1250                 1255                 1260             


Ile Val  Glu Gln Tyr Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn 
    1265                 1270                 1275             


Gly Ile  Arg Ile Lys Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys 
    1280                 1285                 1290             


Glu Lys  Glu Arg Phe Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu 
    1295                 1300                 1305             


Asn Ile  Lys Glu Leu Lys Ala  Gly Tyr Ile Ser Gln  Val Val His 
    1310                 1315                 1320             


Lys Ile  Cys Glu Leu Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu 
    1325                 1330                 1335             


Glu Asp  Leu Asn Ser Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu 
    1340                 1345                 1350             


Lys Gln  Val Tyr Gln Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1355                 1360                 1365             


Asn Tyr  Met Val Asp Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly 
    1370                 1375                 1380             


Ala Leu  Lys Gly Tyr Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys 
    1385                 1390                 1395             


Ser Met  Ser Thr Gln Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp 
    1400                 1405                 1410             


Leu Thr  Ser Lys Ile Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu 
    1415                 1420                 1425             


Lys Thr  Lys Tyr Thr Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser 
    1430                 1435                 1440             


Ser Phe  Asp Arg Ile Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu 
    1445                 1450                 1455             


Phe Ala  Leu Asp Tyr Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr 
    1460                 1465                 1470             


Ile Lys  Lys Trp Lys Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile 
    1475                 1480                 1485             


Phe Arg  Asn Pro Lys Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val 
    1490                 1495                 1500             


Cys Leu  Thr Ser Ala Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile 
    1505                 1510                 1515             


Asn Tyr  Gln Gln Gly Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser 
    1520                 1525                 1530             


Asp Lys  Ala Phe Tyr Ser Ser  Phe Met Ala Leu Met  Ser Leu Met 
    1535                 1540                 1545             


Leu Gln  Met Arg Asn Ser Ile  Thr Gly Arg Thr Asp  Val Asp Phe 
    1550                 1555                 1560             


Leu Ile  Ser Pro Val Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser 
    1565                 1570                 1575             


Arg Asn  Tyr Glu Ala Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala 
    1580                 1585                 1590             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala 
    1595                 1600                 1605             


Ile Gly  Gln Phe Lys Lys Ala  Glu Asp Glu Lys Leu  Asp Lys Val 
    1610                 1615                 1620             


Lys Ile  Ala Ile Ser Asn Lys  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1625                 1630                 1635             


Ser Val  Lys Ser Gly Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu 
    1640                 1645                 1650             


Phe Glu  Pro Lys Lys Lys Arg  Lys Val 
    1655                 1660         


<210>  208
<211>  1662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  208

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg 
            420                 425                 430         


Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys 
        435                 440                 445             


Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val 
    450                 455                 460                 


Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu 
465                 470                 475                 480 


His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg 
                485                 490                 495     


Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu 
            500                 505                 510         


Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly 
        515                 520                 525             


Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu 
    530                 535                 540                 


Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly 
545                 550                 555                 560 


Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe 
                565                 570                 575     


Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu 
            580                 585                 590         


Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp 
        595                 600                 605             


Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu 
    610                 615                 620                 


Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn 
625                 630                 635                 640 


Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly 
                645                 650                 655     


Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr 
            660                 665                 670         


Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys 
        675                 680                 685             


Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr 
    690                 695                 700                 


Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn 
705                 710                 715                 720 


Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu 
                725                 730                 735     


Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val 
            740                 745                 750         


Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu 
        755                 760                 765             


Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His 
    770                 775                 780                 


Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg 
785                 790                 795                 800 


Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu 
                805                 810                 815     


Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile 
            820                 825                 830         


Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys 
        835                 840                 845             


Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp 
    850                 855                 860                 


Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe 
865                 870                 875                 880 


Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg 
                885                 890                 895     


Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu 
            900                 905                 910         


Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys 
        915                 920                 925             


Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe 
    930                 935                 940                 


Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile 
945                 950                 955                 960 


Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr 
                965                 970                 975     


Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr 
            980                 985                 990         


Glu Lys Ile Asn Tyr Lys Leu Leu  Pro Gly Pro Asn Lys  Met Leu Pro 
        995                 1000                 1005             


Lys Val  Phe Phe Ser Lys Lys  Trp Met Ala Tyr Tyr  Asn Pro Ser 
    1010                 1015                 1020             


Glu Asp  Ile Gln Lys Ile Tyr  Lys Asn Gly Thr Phe  Lys Lys Gly 
    1025                 1030                 1035             


Asp Met  Phe Asn Leu Asn Asp  Cys His Lys Leu Ile  Asp Phe Phe 
    1040                 1045                 1050             


Lys Asp  Ser Ile Ser Arg Tyr  Pro Lys Trp Ser Asn  Ala Tyr Asp 
    1055                 1060                 1065             


Phe Asn  Phe Ser Glu Thr Glu  Lys Tyr Lys Asp Ile  Ala Gly Phe 
    1070                 1075                 1080             


Tyr Arg  Glu Val Glu Glu Gln  Gly Tyr Lys Val Ser  Phe Glu Ser 
    1085                 1090                 1095             


Ala Ser  Lys Lys Glu Val Asp  Lys Leu Val Glu Glu  Gly Lys Leu 
    1100                 1105                 1110             


Tyr Met  Phe Gln Ile Tyr Asn  Lys Asp Phe Ser Asp  Lys Ser His 
    1115                 1120                 1125             


Gly Thr  Pro Asn Leu His Thr  Met Tyr Phe Lys Leu  Leu Phe Asp 
    1130                 1135                 1140             


Glu Asn  Asn His Gly Gln Ile  Arg Leu Ser Gly Gly  Ala Glu Leu 
    1145                 1150                 1155             


Phe Met  Arg Arg Ala Ser Leu  Lys Lys Glu Glu Leu  Val Val His 
    1160                 1165                 1170             


Pro Ala  Asn Ser Pro Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys 
    1175                 1180                 1185             


Lys Thr  Thr Thr Leu Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe 
    1190                 1195                 1200             


Ser Glu  Asp Gln Tyr Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys 
    1205                 1210                 1215             


Cys Pro  Lys Asn Ile Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu 
    1220                 1225                 1230             


Leu Lys  His Asp Asp Asn Pro  Tyr Val Ile Gly Ile  Ala Arg Gly 
    1235                 1240                 1245             


Glu Arg  Asn Leu Leu Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn 
    1250                 1255                 1260             


Ile Val  Glu Gln Tyr Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn 
    1265                 1270                 1275             


Gly Ile  Arg Ile Lys Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys 
    1280                 1285                 1290             


Glu Lys  Glu Arg Phe Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu 
    1295                 1300                 1305             


Asn Ile  Lys Glu Leu Lys Ala  Gly Tyr Ile Ser Gln  Val Val His 
    1310                 1315                 1320             


Lys Ile  Cys Glu Leu Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu 
    1325                 1330                 1335             


Glu Asp  Leu Asn Ser Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu 
    1340                 1345                 1350             


Lys Gln  Val Tyr Gln Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1355                 1360                 1365             


Asn Tyr  Met Val Asp Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly 
    1370                 1375                 1380             


Ala Leu  Lys Gly Tyr Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys 
    1385                 1390                 1395             


Ser Met  Ser Thr Gln Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp 
    1400                 1405                 1410             


Leu Thr  Ser Lys Ile Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu 
    1415                 1420                 1425             


Lys Thr  Lys Tyr Thr Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser 
    1430                 1435                 1440             


Ser Phe  Asp Arg Ile Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu 
    1445                 1450                 1455             


Phe Ala  Leu Asp Tyr Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr 
    1460                 1465                 1470             


Ile Lys  Lys Trp Lys Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile 
    1475                 1480                 1485             


Phe Arg  Asn Pro Lys Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val 
    1490                 1495                 1500             


Cys Leu  Thr Ser Ala Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile 
    1505                 1510                 1515             


Asn Tyr  Gln Gln Gly Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser 
    1520                 1525                 1530             


Asp Lys  Ala Phe Tyr Ser Ser  Phe Met Ala Leu Met  Ser Leu Met 
    1535                 1540                 1545             


Leu Gln  Met Arg Asn Ser Ile  Thr Gly Arg Thr Asp  Val Asp Phe 
    1550                 1555                 1560             


Leu Ile  Ser Pro Val Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser 
    1565                 1570                 1575             


Arg Asn  Tyr Glu Ala Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala 
    1580                 1585                 1590             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala 
    1595                 1600                 1605             


Ile Gly  Gln Phe Lys Lys Ala  Glu Asp Glu Lys Leu  Asp Lys Val 
    1610                 1615                 1620             


Lys Ile  Ala Ile Ser Asn Lys  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1625                 1630                 1635             


Ser Val  Lys Ser Gly Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu 
    1640                 1645                 1650             


Phe Glu  Pro Lys Lys Lys Arg  Lys Val 
    1655                 1660         


<210>  209
<211>  1545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  209

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Thr Gln Phe Glu Gly Phe 
    210                 215                 220                 


Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro 
225                 230                 235                 240 


Gln Gly Lys Thr Leu Lys His Ile Gln Glu Gln Gly Phe Ile Glu Glu 
                245                 250                 255     


Asp Lys Ala Arg Asn Asp His Tyr Lys Glu Leu Lys Pro Ile Ile Asp 
            260                 265                 270         


Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys Leu Gln Leu Val Gln Leu 
        275                 280                 285             


Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys 
    290                 295                 300                 


Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg 
305                 310                 315                 320 


Asn Ala Ile His Asp Tyr Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp 
                325                 330                 335     


Ala Ile Asn Lys Arg His Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala 
            340                 345                 350         


Glu Leu Phe Asn Gly Lys Val Leu Lys Gln Leu Gly Thr Val Thr Thr 
        355                 360                 365             


Thr Glu His Glu Asn Ala Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr 
    370                 375                 380                 


Tyr Phe Ser Gly Phe Tyr Arg Asn Arg Lys Asn Val Phe Ser Ala Glu 
385                 390                 395                 400 


Asp Ile Ser Thr Ala Ile Pro His Arg Ile Val Gln Asp Asn Phe Pro 
                405                 410                 415     


Lys Phe Lys Glu Asn Cys His Ile Phe Thr Arg Leu Ile Thr Ala Val 
            420                 425                 430         


Pro Ser Leu Arg Glu His Phe Glu Asn Val Lys Lys Ala Ile Gly Ile 
        435                 440                 445             


Phe Val Ser Thr Ser Ile Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn 
    450                 455                 460                 


Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly 
465                 470                 475                 480 


Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Asn Leu Ala Ile Gln Lys Asn Asp Glu Thr Ala His Ile Ile 
            500                 505                 510         


Ala Ser Leu Pro His Arg Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser 
        515                 520                 525             


Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu 
    530                 535                 540                 


Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu 
545                 550                 555                 560 


Asn Val Leu Glu Thr Ala Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile 
                565                 570                 575     


Asp Leu Thr His Ile Phe Ile Ser His Lys Lys Leu Glu Thr Ile Ser 
            580                 585                 590         


Ser Ala Leu Cys Asp His Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu 
        595                 600                 605             


Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu 
    610                 615                 620                 


Lys Val Gln Arg Ser Leu Lys His Glu Asp Ile Asn Leu Gln Glu Ile 
625                 630                 635                 640 


Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr 
                645                 650                 655     


Ser Glu Ile Leu Ser His Ala His Ala Ala Leu Asp Gln Pro Leu Pro 
            660                 665                 670         


Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu 
        675                 680                 685             


Asp Ser Leu Leu Gly Leu Tyr His Leu Leu Asp Trp Phe Ala Val Asp 
    690                 695                 700                 


Glu Ser Asn Glu Val Asp Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile 
705                 710                 715                 720 


Lys Leu Glu Met Glu Pro Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn 
                725                 730                 735     


Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe 
            740                 745                 750         


Gln Met Pro Thr Leu Ala Arg Gly Trp Asp Val Asn Arg Glu Lys Asn 
        755                 760                 765             


Asn Gly Ala Ile Leu Phe Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile 
    770                 775                 780                 


Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr 
785                 790                 795                 800 


Glu Lys Thr Ser Glu Gly Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro 
                805                 810                 815     


Asp Ala Ala Lys Met Ile Pro Lys Cys Ser Thr Gln Leu Lys Ala Val 
            820                 825                 830         


Thr Ala His Phe Gln Thr His Thr Thr Pro Ile Leu Leu Ser Asn Asn 
        835                 840                 845             


Phe Ile Glu Pro Leu Glu Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn 
    850                 855                 860                 


Pro Glu Lys Glu Pro Lys Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr 
865                 870                 875                 880 


Gly Asp Gln Lys Gly Tyr Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe 
                885                 890                 895     


Thr Arg Asp Phe Leu Ser Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu 
            900                 905                 910         


Ser Ser Leu Arg Pro Ser Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr 
        915                 920                 925             


Ala Glu Leu Asn Pro Leu Leu Tyr His Ile Ser Phe Gln Arg Ile Ala 
    930                 935                 940                 


Glu Lys Glu Ile Met Asp Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe 
945                 950                 955                 960 


Gln Ile Tyr Asn Lys Asp Phe Ala Lys Gly His His Gly Lys Pro Asn 
                965                 970                 975     


Leu His Thr Leu Tyr Trp Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala 
            980                 985                 990         


Lys Thr Ser Ile Lys Leu Asn Gly  Gln Ala Glu Leu Phe  Tyr Arg Pro 
        995                 1000                 1005             


Lys Ser  Arg Met Lys Arg Met  Ala His Arg Leu Gly  Glu Lys Met 
    1010                 1015                 1020             


Leu Asn  Lys Lys Leu Lys Asp  Gln Lys Thr Pro Ile  Pro Asp Thr 
    1025                 1030                 1035             


Leu Tyr  Gln Glu Leu Tyr Asp  Tyr Val Asn His Arg  Leu Ser His 
    1040                 1045                 1050             


Asp Leu  Ser Asp Glu Ala Arg  Ala Leu Leu Pro Asn  Val Ile Thr 
    1055                 1060                 1065             


Lys Glu  Val Ser His Glu Ile  Ile Lys Asp Arg Arg  Phe Thr Ser 
    1070                 1075                 1080             


Asp Lys  Phe Phe Phe His Val  Pro Ile Thr Leu Asn  Tyr Gln Ala 
    1085                 1090                 1095             


Ala Asn  Ser Pro Ser Lys Phe  Asn Gln Arg Val Asn  Ala Tyr Leu 
    1100                 1105                 1110             


Lys Glu  His Pro Glu Thr Pro  Ile Ile Gly Ile Ala  Arg Gly Glu 
    1115                 1120                 1125             


Arg Asn  Leu Ile Tyr Ile Thr  Val Ile Asp Ser Thr  Gly Lys Ile 
    1130                 1135                 1140             


Leu Glu  Gln Arg Ser Leu Asn  Thr Ile Gln Gln Phe  Asp Tyr Gln 
    1145                 1150                 1155             


Lys Lys  Leu Asp Asn Arg Glu  Lys Glu Arg Val Ala  Ala Arg Gln 
    1160                 1165                 1170             


Ala Trp  Ser Val Val Gly Thr  Ile Lys Asp Leu Lys  Gln Gly Tyr 
    1175                 1180                 1185             


Leu Ser  Gln Val Ile His Glu  Ile Val Asp Leu Met  Ile His Tyr 
    1190                 1195                 1200             


Gln Ala  Val Val Val Leu Glu  Asn Leu Asn Phe Gly  Phe Lys Ser 
    1205                 1210                 1215             


Lys Arg  Thr Gly Ile Ala Glu  Lys Ala Val Tyr Gln  Gln Phe Glu 
    1220                 1225                 1230             


Lys Met  Leu Ile Asp Lys Leu  Asn Cys Leu Val Leu  Lys Asp Tyr 
    1235                 1240                 1245             


Pro Ala  Glu Lys Val Gly Gly  Val Leu Asn Pro Tyr  Gln Leu Thr 
    1250                 1255                 1260             


Asp Gln  Phe Thr Ser Phe Ala  Lys Met Gly Thr Gln  Ser Gly Phe 
    1265                 1270                 1275             


Leu Phe  Tyr Val Pro Ala Pro  Tyr Thr Ser Lys Ile  Asp Pro Leu 
    1280                 1285                 1290             


Thr Gly  Phe Val Asp Pro Phe  Val Trp Lys Thr Ile  Lys Asn His 
    1295                 1300                 1305             


Glu Ser  Arg Lys His Phe Leu  Glu Gly Phe Asp Phe  Leu His Tyr 
    1310                 1315                 1320             


Asp Val  Lys Thr Gly Asp Phe  Ile Leu His Phe Lys  Met Asn Arg 
    1325                 1330                 1335             


Asn Leu  Ser Phe Gln Arg Gly  Leu Pro Gly Phe Met  Pro Ala Trp 
    1340                 1345                 1350             


Asp Ile  Val Phe Glu Lys Asn  Glu Thr Gln Phe Asp  Ala Lys Gly 
    1355                 1360                 1365             


Thr Pro  Phe Ile Ala Gly Lys  Arg Ile Val Pro Val  Ile Glu Asn 
    1370                 1375                 1380             


His Arg  Phe Thr Gly Arg Tyr  Arg Asp Leu Tyr Pro  Ala Asn Glu 
    1385                 1390                 1395             


Leu Ile  Ala Leu Leu Glu Glu  Lys Gly Ile Val Phe  Arg Asp Gly 
    1400                 1405                 1410             


Ser Asn  Ile Leu Pro Lys Leu  Leu Glu Asn Asp Asp  Ser His Ala 
    1415                 1420                 1425             


Ile Asp  Thr Met Val Ala Leu  Ile Arg Ser Val Leu  Gln Met Arg 
    1430                 1435                 1440             


Asn Ser  Asn Ala Ala Thr Gly  Glu Asp Tyr Ile Asn  Ser Pro Val 
    1445                 1450                 1455             


Arg Asp  Leu Asn Gly Val Cys  Phe Asp Ser Arg Phe  Gln Asn Pro 
    1460                 1465                 1470             


Glu Trp  Pro Met Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1475                 1480                 1485             


Leu Lys  Gly Gln Leu Leu Leu  Asn His Leu Lys Glu  Ser Lys Asp 
    1490                 1495                 1500             


Leu Lys  Leu Gln Asn Gly Ile  Ser Asn Gln Asp Trp  Leu Ala Tyr 
    1505                 1510                 1515             


Ile Gln  Glu Leu Arg Asn Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1520                 1525                 1530             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1535                 1540                 1545 


<210>  210
<211>  1743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  210

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met 
                405                 410                 415     


Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu 
            420                 425                 430         


Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu 
        435                 440                 445             


Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu 
    450                 455                 460                 


Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys 
465                 470                 475                 480 


Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp 
                485                 490                 495     


Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu 
            500                 505                 510         


Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg 
        515                 520                 525             


Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr 
    530                 535                 540                 


Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln 
545                 550                 555                 560 


Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser 
                565                 570                 575     


Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Arg Asn Arg Lys 
            580                 585                 590         


Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile 
        595                 600                 605             


Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr 
    610                 615                 620                 


Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val 
625                 630                 635                 640 


Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe 
                645                 650                 655     


Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu 
            660                 665                 670         


Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys 
        675                 680                 685             


Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp 
    690                 695                 700                 


Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu 
705                 710                 715                 720 


Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu 
                725                 730                 735     


Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys 
            740                 745                 750         


Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe 
        755                 760                 765             


Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys 
    770                 775                 780                 


Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu 
785                 790                 795                 800 


Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile 
                805                 810                 815     


Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp 
            820                 825                 830         


Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu 
        835                 840                 845             


Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala 
    850                 855                 860                 


Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu 
865                 870                 875                 880 


Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu 
                885                 890                 895     


Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser 
            900                 905                 910         


Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe 
        915                 920                 925             


Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu 
    930                 935                 940                 


Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Arg Gly Trp Asp 
945                 950                 955                 960 


Val Asn Arg Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly 
                965                 970                 975     


Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala 
            980                 985                 990         


Leu Ser Phe Glu Pro Thr Glu Lys  Thr Ser Glu Gly Phe  Asp Lys Met 
        995                 1000                 1005             


Tyr Tyr  Asp Tyr Phe Pro Asp  Ala Ala Lys Met Ile  Pro Lys Cys 
    1010                 1015                 1020             


Ser Thr  Gln Leu Lys Ala Val  Thr Ala His Phe Gln  Thr His Thr 
    1025                 1030                 1035             


Thr Pro  Ile Leu Leu Ser Asn  Asn Phe Ile Glu Pro  Leu Glu Ile 
    1040                 1045                 1050             


Thr Lys  Glu Ile Tyr Asp Leu  Asn Asn Pro Glu Lys  Glu Pro Lys 
    1055                 1060                 1065             


Lys Phe  Gln Thr Ala Tyr Ala  Lys Lys Thr Gly Asp  Gln Lys Gly 
    1070                 1075                 1080             


Tyr Arg  Glu Ala Leu Cys Lys  Trp Ile Asp Phe Thr  Arg Asp Phe 
    1085                 1090                 1095             


Leu Ser  Lys Tyr Thr Lys Thr  Thr Ser Ile Asp Leu  Ser Ser Leu 
    1100                 1105                 1110             


Arg Pro  Ser Ser Gln Tyr Lys  Asp Leu Gly Glu Tyr  Tyr Ala Glu 
    1115                 1120                 1125             


Leu Asn  Pro Leu Leu Tyr His  Ile Ser Phe Gln Arg  Ile Ala Glu 
    1130                 1135                 1140             


Lys Glu  Ile Met Asp Ala Val  Glu Thr Gly Lys Leu  Tyr Leu Phe 
    1145                 1150                 1155             


Gln Ile  Tyr Asn Lys Asp Phe  Ala Lys Gly His His  Gly Lys Pro 
    1160                 1165                 1170             


Asn Leu  His Thr Leu Tyr Trp  Thr Gly Leu Phe Ser  Pro Glu Asn 
    1175                 1180                 1185             


Leu Ala  Lys Thr Ser Ile Lys  Leu Asn Gly Gln Ala  Glu Leu Phe 
    1190                 1195                 1200             


Tyr Arg  Pro Lys Ser Arg Met  Lys Arg Met Ala His  Arg Leu Gly 
    1205                 1210                 1215             


Glu Lys  Met Leu Asn Lys Lys  Leu Lys Asp Gln Lys  Thr Pro Ile 
    1220                 1225                 1230             


Pro Asp  Thr Leu Tyr Gln Glu  Leu Tyr Asp Tyr Val  Asn His Arg 
    1235                 1240                 1245             


Leu Ser  His Asp Leu Ser Asp  Glu Ala Arg Ala Leu  Leu Pro Asn 
    1250                 1255                 1260             


Val Ile  Thr Lys Glu Val Ser  His Glu Ile Ile Lys  Asp Arg Arg 
    1265                 1270                 1275             


Phe Thr  Ser Asp Lys Phe Phe  Phe His Val Pro Ile  Thr Leu Asn 
    1280                 1285                 1290             


Tyr Gln  Ala Ala Asn Ser Pro  Ser Lys Phe Asn Gln  Arg Val Asn 
    1295                 1300                 1305             


Ala Tyr  Leu Lys Glu His Pro  Glu Thr Pro Ile Ile  Gly Ile Ala 
    1310                 1315                 1320             


Arg Gly  Glu Arg Asn Leu Ile  Tyr Ile Thr Val Ile  Asp Ser Thr 
    1325                 1330                 1335             


Gly Lys  Ile Leu Glu Gln Arg  Ser Leu Asn Thr Ile  Gln Gln Phe 
    1340                 1345                 1350             


Asp Tyr  Gln Lys Lys Leu Asp  Asn Arg Glu Lys Glu  Arg Val Ala 
    1355                 1360                 1365             


Ala Arg  Gln Ala Trp Ser Val  Val Gly Thr Ile Lys  Asp Leu Lys 
    1370                 1375                 1380             


Gln Gly  Tyr Leu Ser Gln Val  Ile His Glu Ile Val  Asp Leu Met 
    1385                 1390                 1395             


Ile His  Tyr Gln Ala Val Val  Val Leu Glu Asn Leu  Asn Phe Gly 
    1400                 1405                 1410             


Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu Lys Ala  Val Tyr Gln 
    1415                 1420                 1425             


Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu Asn Cys  Leu Val Leu 
    1430                 1435                 1440             


Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly Val Leu  Asn Pro Tyr 
    1445                 1450                 1455             


Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala Lys Met  Gly Thr Gln 
    1460                 1465                 1470             


Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro Tyr Thr  Ser Lys Ile 
    1475                 1480                 1485             


Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe Val Trp  Lys Thr Ile 
    1490                 1495                 1500             


Lys Asn  His Glu Ser Arg Lys  His Phe Leu Glu Gly  Phe Asp Phe 
    1505                 1510                 1515             


Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe Ile Leu  His Phe Lys 
    1520                 1525                 1530             


Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly Leu Pro  Gly Phe Met 
    1535                 1540                 1545             


Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn Glu Thr  Gln Phe Asp 
    1550                 1555                 1560             


Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys Arg Ile  Val Pro Val 
    1565                 1570                 1575             


Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr Arg Asp  Leu Tyr Pro 
    1580                 1585                 1590             


Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu Lys Gly  Ile Val Phe 
    1595                 1600                 1605             


Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu Leu Glu  Asn Asp Asp 
    1610                 1615                 1620             


Ser His  Ala Ile Asp Thr Met  Val Ala Leu Ile Arg  Ser Val Leu 
    1625                 1630                 1635             


Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly Glu Asp  Tyr Ile Asn 
    1640                 1645                 1650             


Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys Phe Asp  Ser Arg Phe 
    1655                 1660                 1665             


Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1670                 1675                 1680             


His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu Asn His  Leu Lys Glu 
    1685                 1690                 1695             


Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile Ser Asn  Gln Asp Trp 
    1700                 1705                 1710             


Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Ser Gly Gly  Ser Lys Arg 
    1715                 1720                 1725             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1730                 1735                 1740             


<210>  211
<211>  1743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  211

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met 
                405                 410                 415     


Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu 
            420                 425                 430         


Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu 
        435                 440                 445             


Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu 
    450                 455                 460                 


Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys 
465                 470                 475                 480 


Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp 
                485                 490                 495     


Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu 
            500                 505                 510         


Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg 
        515                 520                 525             


Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr 
    530                 535                 540                 


Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln 
545                 550                 555                 560 


Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser 
                565                 570                 575     


Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Arg Asn Arg Lys 
            580                 585                 590         


Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile 
        595                 600                 605             


Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr 
    610                 615                 620                 


Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val 
625                 630                 635                 640 


Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe 
                645                 650                 655     


Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu 
            660                 665                 670         


Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys 
        675                 680                 685             


Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp 
    690                 695                 700                 


Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu 
705                 710                 715                 720 


Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu 
                725                 730                 735     


Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys 
            740                 745                 750         


Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe 
        755                 760                 765             


Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys 
    770                 775                 780                 


Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu 
785                 790                 795                 800 


Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile 
                805                 810                 815     


Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp 
            820                 825                 830         


Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu 
        835                 840                 845             


Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala 
    850                 855                 860                 


Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu 
865                 870                 875                 880 


Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu 
                885                 890                 895     


Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser 
            900                 905                 910         


Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe 
        915                 920                 925             


Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu 
    930                 935                 940                 


Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Arg Gly Trp Asp 
945                 950                 955                 960 


Val Asn Arg Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly 
                965                 970                 975     


Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala 
            980                 985                 990         


Leu Ser Phe Glu Pro Thr Glu Lys  Thr Ser Glu Gly Phe  Asp Lys Met 
        995                 1000                 1005             


Tyr Tyr  Asp Tyr Phe Pro Asp  Ala Ala Lys Met Ile  Pro Lys Cys 
    1010                 1015                 1020             


Ser Thr  Gln Leu Lys Ala Val  Thr Ala His Phe Gln  Thr His Thr 
    1025                 1030                 1035             


Thr Pro  Ile Leu Leu Ser Asn  Asn Phe Ile Glu Pro  Leu Glu Ile 
    1040                 1045                 1050             


Thr Lys  Glu Ile Tyr Asp Leu  Asn Asn Pro Glu Lys  Glu Pro Lys 
    1055                 1060                 1065             


Lys Phe  Gln Thr Ala Tyr Ala  Lys Lys Thr Gly Asp  Gln Lys Gly 
    1070                 1075                 1080             


Tyr Arg  Glu Ala Leu Cys Lys  Trp Ile Asp Phe Thr  Arg Asp Phe 
    1085                 1090                 1095             


Leu Ser  Lys Tyr Thr Lys Thr  Thr Ser Ile Asp Leu  Ser Ser Leu 
    1100                 1105                 1110             


Arg Pro  Ser Ser Gln Tyr Lys  Asp Leu Gly Glu Tyr  Tyr Ala Glu 
    1115                 1120                 1125             


Leu Asn  Pro Leu Leu Tyr His  Ile Ser Phe Gln Arg  Ile Ala Glu 
    1130                 1135                 1140             


Lys Glu  Ile Met Asp Ala Val  Glu Thr Gly Lys Leu  Tyr Leu Phe 
    1145                 1150                 1155             


Gln Ile  Tyr Asn Lys Asp Phe  Ala Lys Gly His His  Gly Lys Pro 
    1160                 1165                 1170             


Asn Leu  His Thr Leu Tyr Trp  Thr Gly Leu Phe Ser  Pro Glu Asn 
    1175                 1180                 1185             


Leu Ala  Lys Thr Ser Ile Lys  Leu Asn Gly Gln Ala  Glu Leu Phe 
    1190                 1195                 1200             


Tyr Arg  Pro Lys Ser Arg Met  Lys Arg Met Ala His  Arg Leu Gly 
    1205                 1210                 1215             


Glu Lys  Met Leu Asn Lys Lys  Leu Lys Asp Gln Lys  Thr Pro Ile 
    1220                 1225                 1230             


Pro Asp  Thr Leu Tyr Gln Glu  Leu Tyr Asp Tyr Val  Asn His Arg 
    1235                 1240                 1245             


Leu Ser  His Asp Leu Ser Asp  Glu Ala Arg Ala Leu  Leu Pro Asn 
    1250                 1255                 1260             


Val Ile  Thr Lys Glu Val Ser  His Glu Ile Ile Lys  Asp Arg Arg 
    1265                 1270                 1275             


Phe Thr  Ser Asp Lys Phe Phe  Phe His Val Pro Ile  Thr Leu Asn 
    1280                 1285                 1290             


Tyr Gln  Ala Ala Asn Ser Pro  Ser Lys Phe Asn Gln  Arg Val Asn 
    1295                 1300                 1305             


Ala Tyr  Leu Lys Glu His Pro  Glu Thr Pro Ile Ile  Gly Ile Ala 
    1310                 1315                 1320             


Arg Gly  Glu Arg Asn Leu Ile  Tyr Ile Thr Val Ile  Asp Ser Thr 
    1325                 1330                 1335             


Gly Lys  Ile Leu Glu Gln Arg  Ser Leu Asn Thr Ile  Gln Gln Phe 
    1340                 1345                 1350             


Asp Tyr  Gln Lys Lys Leu Asp  Asn Arg Glu Lys Glu  Arg Val Ala 
    1355                 1360                 1365             


Ala Arg  Gln Ala Trp Ser Val  Val Gly Thr Ile Lys  Asp Leu Lys 
    1370                 1375                 1380             


Gln Gly  Tyr Leu Ser Gln Val  Ile His Glu Ile Val  Asp Leu Met 
    1385                 1390                 1395             


Ile His  Tyr Gln Ala Val Val  Val Leu Glu Asn Leu  Asn Phe Gly 
    1400                 1405                 1410             


Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu Lys Ala  Val Tyr Gln 
    1415                 1420                 1425             


Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu Asn Cys  Leu Val Leu 
    1430                 1435                 1440             


Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly Val Leu  Asn Pro Tyr 
    1445                 1450                 1455             


Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala Lys Met  Gly Thr Gln 
    1460                 1465                 1470             


Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro Tyr Thr  Ser Lys Ile 
    1475                 1480                 1485             


Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe Val Trp  Lys Thr Ile 
    1490                 1495                 1500             


Lys Asn  His Glu Ser Arg Lys  His Phe Leu Glu Gly  Phe Asp Phe 
    1505                 1510                 1515             


Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe Ile Leu  His Phe Lys 
    1520                 1525                 1530             


Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly Leu Pro  Gly Phe Met 
    1535                 1540                 1545             


Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn Glu Thr  Gln Phe Asp 
    1550                 1555                 1560             


Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys Arg Ile  Val Pro Val 
    1565                 1570                 1575             


Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr Arg Asp  Leu Tyr Pro 
    1580                 1585                 1590             


Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu Lys Gly  Ile Val Phe 
    1595                 1600                 1605             


Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu Leu Glu  Asn Asp Asp 
    1610                 1615                 1620             


Ser His  Ala Ile Asp Thr Met  Val Ala Leu Ile Arg  Ser Val Leu 
    1625                 1630                 1635             


Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly Glu Asp  Tyr Ile Asn 
    1640                 1645                 1650             


Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys Phe Asp  Ser Arg Phe 
    1655                 1660                 1665             


Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1670                 1675                 1680             


His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu Asn His  Leu Lys Glu 
    1685                 1690                 1695             


Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile Ser Asn  Gln Asp Trp 
    1700                 1705                 1710             


Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Ser Gly Gly  Ser Lys Arg 
    1715                 1720                 1725             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1730                 1735                 1740             


<210>  212
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  212

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Arg Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Val Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Arg Phe  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Arg Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Val Tyr Arg Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  213
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  213

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Arg  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Arg Phe Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Arg Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Val Tyr  Arg Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  214
<211>  1291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  214

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu 
    210                 215                 220                 


Gly Leu Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr 
225                 230                 235                 240 


Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala 
                245                 250                 255     


Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg 
            260                 265                 270         


Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu 
        275                 280                 285             


Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn 
    290                 295                 300                 


Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu 
305                 310                 315                 320 


Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His 
                325                 330                 335     


Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys 
            340                 345                 350         


Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala 
        355                 360                 365             


Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser 
    370                 375                 380                 


Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu 
385                 390                 395                 400 


Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp 
                405                 410                 415     


Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro 
            420                 425                 430         


Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu 
        435                 440                 445             


Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val 
    450                 455                 460                 


Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn 
465                 470                 475                 480 


Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu 
                485                 490                 495     


Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr 
            500                 505                 510         


Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys 
        515                 520                 525             


Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys 
    530                 535                 540                 


Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu 
545                 550                 555                 560 


Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln 
                565                 570                 575     


Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu 
            580                 585                 590         


Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly 
        595                 600                 605             


Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu 
    610                 615                 620                 


Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu 
625                 630                 635                 640 


Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr 
                645                 650                 655     


Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile 
            660                 665                 670         


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro 
        675                 680                 685             


Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala 
    690                 695                 700                 


Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu 
705                 710                 715                 720 


Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr 
                725                 730                 735     


Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu 
            740                 745                 750         


Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe 
        755                 760                 765             


Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn 
    770                 775                 780                 


Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys 
785                 790                 795                 800 


Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile 
                805                 810                 815     


Ser Tyr Glu Thr Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys 
            820                 825                 830         


Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp 
        835                 840                 845             


Ile Asn Arg Phe Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val 
    850                 855                 860                 


Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr 
865                 870                 875                 880 


Phe Arg Val Asn Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly 
                885                 890                 895     


Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn 
            900                 905                 910         


Lys Gly Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala 
        915                 920                 925             


Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val 
    930                 935                 940                 


Met Glu Asn Gln Met Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu 
945                 950                 955                 960 


Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile Phe Ile Thr Pro His Gln 
                965                 970                 975     


Ile Lys His Ile Lys Asp Phe Lys Asp Tyr Lys Tyr Ser His Arg Val 
            980                 985                 990         


Asp Lys Lys Pro Asn Arg Glu Leu  Ile Asn Asp Thr Leu  Tyr Ser Thr 
        995                 1000                 1005             


Arg Lys  Asp Asp Lys Gly Asn  Thr Leu Ile Val Asn  Asn Leu Asn 
    1010                 1015                 1020             


Gly Leu  Tyr Asp Lys Asp Asn  Asp Lys Leu Lys Lys  Leu Ile Asn 
    1025                 1030                 1035             


Lys Ser  Pro Glu Lys Leu Leu  Met Tyr His His Asp  Pro Gln Thr 
    1040                 1045                 1050             


Tyr Gln  Lys Leu Lys Leu Ile  Met Glu Gln Tyr Gly  Asp Glu Lys 
    1055                 1060                 1065             


Asn Pro  Leu Tyr Lys Tyr Tyr  Glu Glu Thr Gly Asn  Tyr Leu Thr 
    1070                 1075                 1080             


Lys Tyr  Ser Lys Lys Asp Asn  Gly Pro Val Ile Lys  Lys Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Gly Asn Lys Leu Asn  Ala His Leu Asp Ile  Thr Asp Asp 
    1100                 1105                 1110             


Tyr Pro  Asn Ser Arg Asn Lys  Val Val Lys Leu Ser  Leu Lys Pro 
    1115                 1120                 1125             


Tyr Arg  Phe Asp Val Tyr Leu  Asp Asn Gly Val Tyr  Lys Phe Val 
    1130                 1135                 1140             


Thr Val  Lys Asn Leu Asp Val  Ile Lys Lys Glu Asn  Tyr Tyr Glu 
    1145                 1150                 1155             


Val Asn  Ser Lys Cys Tyr Glu  Glu Ala Lys Lys Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ser Asn  Gln Ala Glu Phe Ile  Ala Ser Phe Tyr Asn  Asn Asp Leu 
    1175                 1180                 1185             


Ile Lys  Ile Asn Gly Glu Leu  Tyr Arg Val Ile Gly  Val Asn Asn 
    1190                 1195                 1200             


Asp Leu  Leu Asn Arg Ile Glu  Val Asn Met Ile Asp  Ile Thr Tyr 
    1205                 1210                 1215             


Arg Glu  Tyr Leu Glu Asn Met  Asn Asp Lys Arg Pro  Pro Arg Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Ala Ser Lys  Thr Gln Ser Ile Lys  Lys Tyr Ser 
    1235                 1240                 1245             


Thr Asp  Ile Leu Gly Asn Leu  Tyr Glu Val Lys Ser  Lys Lys His 
    1250                 1255                 1260             


Pro Gln  Ile Ile Lys Lys Gly  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1265                 1270                 1275             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1280                 1285                 1290     


<210>  215
<211>  1489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  215

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly 
                405                 410                 415     


Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val Gly 
            420                 425                 430         


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
        435                 440                 445             


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
    450                 455                 460                 


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
465                 470                 475                 480 


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
                485                 490                 495     


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
            500                 505                 510         


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
        515                 520                 525             


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
    530                 535                 540                 


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
545                 550                 555                 560 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
                565                 570                 575     


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
            580                 585                 590         


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
        595                 600                 605             


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
    610                 615                 620                 


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
625                 630                 635                 640 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
                645                 650                 655     


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
            660                 665                 670         


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
        675                 680                 685             


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
    690                 695                 700                 


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
705                 710                 715                 720 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
                725                 730                 735     


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
            740                 745                 750         


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
        755                 760                 765             


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
    770                 775                 780                 


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
785                 790                 795                 800 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
                805                 810                 815     


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
            820                 825                 830         


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
        835                 840                 845             


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
    850                 855                 860                 


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
865                 870                 875                 880 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
                885                 890                 895     


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
            900                 905                 910         


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
        915                 920                 925             


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
    930                 935                 940                 


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
945                 950                 955                 960 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
                965                 970                 975     


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
            980                 985                 990         


Glu Glu Asn Ser Lys Lys Gly Asn  Arg Thr Pro Phe Gln  Tyr Leu Ser 
        995                 1000                 1005             


Ser Ser  Asp Ser Lys Ile Ser  Tyr Glu Thr Phe Lys  Lys His Ile 
    1010                 1015                 1020             


Leu Asn  Leu Ala Lys Gly Lys  Gly Arg Ile Ser Lys  Thr Lys Lys 
    1025                 1030                 1035             


Glu Tyr  Leu Leu Glu Glu Arg  Asp Ile Asn Arg Phe  Ser Val Gln 
    1040                 1045                 1050             


Lys Asp  Phe Ile Asn Arg Asn  Leu Val Asp Thr Arg  Tyr Ala Thr 
    1055                 1060                 1065             


Arg Gly  Leu Met Asn Leu Leu  Arg Ser Tyr Phe Arg  Val Asn Asn 
    1070                 1075                 1080             


Leu Asp  Val Lys Val Lys Ser  Ile Asn Gly Gly Phe  Thr Ser Phe 
    1085                 1090                 1095             


Leu Arg  Arg Lys Trp Lys Phe  Lys Lys Glu Arg Asn  Lys Gly Tyr 
    1100                 1105                 1110             


Lys His  His Ala Glu Asp Ala  Leu Ile Ile Ala Asn  Ala Asp Phe 
    1115                 1120                 1125             


Ile Phe  Lys Glu Trp Lys Lys  Leu Asp Lys Ala Lys  Lys Val Met 
    1130                 1135                 1140             


Glu Asn  Gln Met Phe Glu Glu  Lys Gln Ala Glu Ser  Met Pro Glu 
    1145                 1150                 1155             


Ile Glu  Thr Glu Gln Glu Tyr  Lys Glu Ile Phe Ile  Thr Pro His 
    1160                 1165                 1170             


Gln Ile  Lys His Ile Lys Asp  Phe Lys Asp Tyr Lys  Tyr Ser His 
    1175                 1180                 1185             


Arg Val  Asp Lys Lys Pro Asn  Arg Glu Leu Ile Asn  Asp Thr Leu 
    1190                 1195                 1200             


Tyr Ser  Thr Arg Lys Asp Asp  Lys Gly Asn Thr Leu  Ile Val Asn 
    1205                 1210                 1215             


Asn Leu  Asn Gly Leu Tyr Asp  Lys Asp Asn Asp Lys  Leu Lys Lys 
    1220                 1225                 1230             


Leu Ile  Asn Lys Ser Pro Glu  Lys Leu Leu Met Tyr  His His Asp 
    1235                 1240                 1245             


Pro Gln  Thr Tyr Gln Lys Leu  Lys Leu Ile Met Glu  Gln Tyr Gly 
    1250                 1255                 1260             


Asp Glu  Lys Asn Pro Leu Tyr  Lys Tyr Tyr Glu Glu  Thr Gly Asn 
    1265                 1270                 1275             


Tyr Leu  Thr Lys Tyr Ser Lys  Lys Asp Asn Gly Pro  Val Ile Lys 
    1280                 1285                 1290             


Lys Ile  Lys Tyr Tyr Gly Asn  Lys Leu Asn Ala His  Leu Asp Ile 
    1295                 1300                 1305             


Thr Asp  Asp Tyr Pro Asn Ser  Arg Asn Lys Val Val  Lys Leu Ser 
    1310                 1315                 1320             


Leu Lys  Pro Tyr Arg Phe Asp  Val Tyr Leu Asp Asn  Gly Val Tyr 
    1325                 1330                 1335             


Lys Phe  Val Thr Val Lys Asn  Leu Asp Val Ile Lys  Lys Glu Asn 
    1340                 1345                 1350             


Tyr Tyr  Glu Val Asn Ser Lys  Cys Tyr Glu Glu Ala  Lys Lys Leu 
    1355                 1360                 1365             


Lys Lys  Ile Ser Asn Gln Ala  Glu Phe Ile Ala Ser  Phe Tyr Asn 
    1370                 1375                 1380             


Asn Asp  Leu Ile Lys Ile Asn  Gly Glu Leu Tyr Arg  Val Ile Gly 
    1385                 1390                 1395             


Val Asn  Asn Asp Leu Leu Asn  Arg Ile Glu Val Asn  Met Ile Asp 
    1400                 1405                 1410             


Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met Asn Asp  Lys Arg Pro 
    1415                 1420                 1425             


Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys Thr Gln  Ser Ile Lys 
    1430                 1435                 1440             


Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu Tyr Glu  Val Lys Ser 
    1445                 1450                 1455             


Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly Ser Gly  Gly Ser Lys 
    1460                 1465                 1470             


Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys 
    1475                 1480                 1485             


Val 
    


<210>  216
<211>  1626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  216

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala Thr Ala 
    210                 215                 220                 


Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile 
225                 230                 235                 240 


Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn 
                245                 250                 255     


Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr 
            260                 265                 270         


Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 
        275                 280                 285             


Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg 
    290                 295                 300                 


Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys 
305                 310                 315                 320 


Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val 
                325                 330                 335     


Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu 
            340                 345                 350         


Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro 
        355                 360                 365             


Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu 
    370                 375                 380                 


Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg 
385                 390                 395                 400 


Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu 
                405                 410                 415     


Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr 
            420                 425                 430         


Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe 
        435                 440                 445             


Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser 
    450                 455                 460                 


Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val 
465                 470                 475                 480 


Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala 
                485                 490                 495     


Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala 
            500                 505                 510         


Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 
        515                 520                 525             


Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly 
    530                 535                 540                 


Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                565                 570                 575     


Gly Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn 
            580                 585                 590         


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        595                 600                 605             


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    610                 615                 620                 


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
625                 630                 635                 640 


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                645                 650                 655     


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            660                 665                 670         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        675                 680                 685             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    690                 695                 700                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
705                 710                 715                 720 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                725                 730                 735     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            740                 745                 750         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        755                 760                 765             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    770                 775                 780                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
785                 790                 795                 800 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                805                 810                 815     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            820                 825                 830         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        835                 840                 845             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    850                 855                 860                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
865                 870                 875                 880 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                885                 890                 895     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            900                 905                 910         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        915                 920                 925             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    930                 935                 940                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
945                 950                 955                 960 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                965                 970                 975     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            980                 985                 990         


His Leu Gly Glu Leu His Ala Ile  Leu Arg Arg Gln Glu  Asp Phe Tyr 
        995                 1000                 1005             


Pro Phe  Leu Lys Asp Asn Arg  Glu Lys Ile Glu Lys  Ile Leu Thr 
    1010                 1015                 1020             


Phe Arg  Ile Pro Tyr Tyr Val  Gly Pro Leu Ala Arg  Gly Asn Ser 
    1025                 1030                 1035             


Arg Phe  Ala Trp Met Thr Arg  Lys Ser Glu Glu Thr  Ile Thr Pro 
    1040                 1045                 1050             


Trp Asn  Phe Glu Glu Val Val  Asp Lys Gly Ala Ser  Ala Gln Ser 
    1055                 1060                 1065             


Phe Ile  Glu Arg Met Thr Asn  Phe Asp Lys Asn Leu  Pro Asn Glu 
    1070                 1075                 1080             


Lys Val  Leu Pro Lys His Ser  Leu Leu Tyr Glu Tyr  Phe Thr Val 
    1085                 1090                 1095             


Tyr Asn  Glu Leu Thr Lys Val  Lys Tyr Val Thr Glu  Gly Met Arg 
    1100                 1105                 1110             


Lys Pro  Ala Phe Leu Ser Gly  Glu Gln Lys Lys Ala  Ile Val Asp 
    1115                 1120                 1125             


Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr Val Lys  Gln Leu Lys 
    1130                 1135                 1140             


Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe Asp Ser  Val Glu Ile 
    1145                 1150                 1155             


Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser Leu Gly  Thr Tyr His 
    1160                 1165                 1170             


Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
    1175                 1180                 1185             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1190                 1195                 1200             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1205                 1210                 1215             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1220                 1225                 1230             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1235                 1240                 1245             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1250                 1255                 1260             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1265                 1270                 1275             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1280                 1285                 1290             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1295                 1300                 1305             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1310                 1315                 1320             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1325                 1330                 1335             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1340                 1345                 1350             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1355                 1360                 1365             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1370                 1375                 1380             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1385                 1390                 1395             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1400                 1405                 1410             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1415                 1420                 1425             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1430                 1435                 1440             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1445                 1450                 1455             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1460                 1465                 1470             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1475                 1480                 1485             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1490                 1495                 1500             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1505                 1510                 1515             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1520                 1525                 1530             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1535                 1540                 1545             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1550                 1555                 1560             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1565                 1570                 1575             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1580                 1585                 1590             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Ser Gly Gly 
    1595                 1600                 1605             


Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys 
    1610                 1615                 1620             


Arg Lys  Val 
    1625     


<210>  217
<211>  1824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  217

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu 
                405                 410                 415     


Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn 
            420                 425                 430         


Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg 
        435                 440                 445             


Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys 
    450                 455                 460                 


Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val 
465                 470                 475                 480 


Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu 
                485                 490                 495     


Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys 
            500                 505                 510         


Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala 
        515                 520                 525             


Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys 
    530                 535                 540                 


Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser 
545                 550                 555                 560 


Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 
                565                 570                 575     


Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe 
            580                 585                 590         


Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu 
        595                 600                 605             


Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu 
    610                 615                 620                 


Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn 
625                 630                 635                 640 


Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu 
                645                 650                 655     


Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp 
            660                 665                 670         


Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys 
        675                 680                 685             


Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr 
    690                 695                 700                 


Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp 
705                 710                 715                 720 


Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile 
                725                 730                 735     


His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln 
            740                 745                 750         


Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        755                 760                 765             


Gly Gly Ser Gly Gly Ser Gly Gly Met Asp Lys Lys Tyr Ser Ile Gly 
    770                 775                 780                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
785                 790                 795                 800 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                805                 810                 815     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            820                 825                 830         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        835                 840                 845             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    850                 855                 860                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
865                 870                 875                 880 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                885                 890                 895     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            900                 905                 910         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        915                 920                 925             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    930                 935                 940                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
945                 950                 955                 960 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                965                 970                 975     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            980                 985                 990         


Ser Lys Ser Arg Arg Leu Glu Asn  Leu Ile Ala Gln Leu  Pro Gly Glu 
        995                 1000                 1005             


Lys Lys  Asn Gly Leu Phe Gly  Asn Leu Ile Ala Leu  Ser Leu Gly 
    1010                 1015                 1020             


Leu Thr  Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
    1025                 1030                 1035             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1040                 1045                 1050             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1055                 1060                 1065             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1070                 1075                 1080             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1085                 1090                 1095             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1100                 1105                 1110             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1115                 1120                 1125             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1130                 1135                 1140             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1145                 1150                 1155             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1160                 1165                 1170             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1175                 1180                 1185             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1190                 1195                 1200             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1205                 1210                 1215             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1220                 1225                 1230             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1235                 1240                 1245             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1250                 1255                 1260             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1265                 1270                 1275             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1280                 1285                 1290             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1295                 1300                 1305             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1310                 1315                 1320             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1325                 1330                 1335             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1340                 1345                 1350             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1355                 1360                 1365             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1370                 1375                 1380             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1385                 1390                 1395             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1400                 1405                 1410             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1415                 1420                 1425             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1430                 1435                 1440             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1445                 1450                 1455             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1460                 1465                 1470             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1475                 1480                 1485             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1490                 1495                 1500             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1505                 1510                 1515             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1520                 1525                 1530             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1535                 1540                 1545             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1550                 1555                 1560             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1565                 1570                 1575             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1580                 1585                 1590             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1595                 1600                 1605             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1610                 1615                 1620             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1625                 1630                 1635             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1640                 1645                 1650             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1655                 1660                 1665             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1670                 1675                 1680             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1685                 1690                 1695             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1700                 1705                 1710             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1715                 1720                 1725             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1730                 1735                 1740             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1745                 1750                 1755             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1760                 1765                 1770             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1775                 1780                 1785             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1790                 1795                 1800             


Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro 
    1805                 1810                 1815             


Lys Lys  Lys Arg Lys Val 
    1820                 


<210>  218
<211>  1625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  218

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Ile Met Asn Phe Phe Lys 
    210                 215                 220                 


Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile 
225                 230                 235                 240 


Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp 
                245                 250                 255     


Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val 
            260                 265                 270         


Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu 
        275                 280                 285             


Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp 
    290                 295                 300                 


Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 
305                 310                 315                 320 


Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser 
                325                 330                 335     


Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu 
            340                 345                 350         


Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys 
        355                 360                 365             


Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu 
    370                 375                 380                 


Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly 
385                 390                 395                 400 


Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala 
                405                 410                 415     


Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys 
            420                 425                 430         


Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu 
        435                 440                 445             


Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu 
    450                 455                 460                 


Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg 
465                 470                 475                 480 


Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly 
                485                 490                 495     


Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg 
            500                 505                 510         


Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser 
        515                 520                 525             


Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly 
    530                 535                 540                 


Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                565                 570                 575     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            580                 585                 590         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        595                 600                 605             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    610                 615                 620                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
625                 630                 635                 640 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                645                 650                 655     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            660                 665                 670         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        675                 680                 685             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    690                 695                 700                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
705                 710                 715                 720 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                725                 730                 735     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            740                 745                 750         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        755                 760                 765             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    770                 775                 780                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
785                 790                 795                 800 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                805                 810                 815     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            820                 825                 830         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        835                 840                 845             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    850                 855                 860                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
865                 870                 875                 880 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                885                 890                 895     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            900                 905                 910         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        915                 920                 925             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    930                 935                 940                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
945                 950                 955                 960 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                965                 970                 975     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            980                 985                 990         


Phe Tyr Pro Phe Leu Lys Asp Asn  Arg Glu Lys Ile Glu  Lys Ile Leu 
        995                 1000                 1005             


Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro Leu Ala  Arg Gly Asn 
    1010                 1015                 1020             


Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser Glu Glu  Thr Ile Thr 
    1025                 1030                 1035             


Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys Gly Ala  Ser Ala Gln 
    1040                 1045                 1050             


Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp Lys Asn  Leu Pro Asn 
    1055                 1060                 1065             


Glu Lys  Val Leu Pro Lys His  Ser Leu Leu Tyr Glu  Tyr Phe Thr 
    1070                 1075                 1080             


Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr Val Thr  Glu Gly Met 
    1085                 1090                 1095             


Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln Lys Lys  Ala Ile Val 
    1100                 1105                 1110             


Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val Thr Val  Lys Gln Leu 
    1115                 1120                 1125             


Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys Phe Asp  Ser Val Glu 
    1130                 1135                 1140             


Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
    1145                 1150                 1155             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1160                 1165                 1170             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1175                 1180                 1185             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1190                 1195                 1200             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1205                 1210                 1215             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1220                 1225                 1230             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1235                 1240                 1245             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1250                 1255                 1260             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1265                 1270                 1275             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1280                 1285                 1290             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1295                 1300                 1305             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1310                 1315                 1320             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1325                 1330                 1335             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1340                 1345                 1350             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1355                 1360                 1365             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1370                 1375                 1380             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1385                 1390                 1395             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1400                 1405                 1410             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1415                 1420                 1425             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1430                 1435                 1440             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1445                 1450                 1455             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1460                 1465                 1470             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1475                 1480                 1485             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1490                 1495                 1500             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1505                 1510                 1515             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1520                 1525                 1530             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1535                 1540                 1545             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1550                 1555                 1560             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1565                 1570                 1575             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1580                 1585                 1590             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Ser  Gly Gly Ser 
    1595                 1600                 1605             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    1610                 1615                 1620             


Lys Val  
    1625 


<210>  219
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  219

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  220
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  220

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  221
<211>  2135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  221

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1835                 1840                 1845             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1850                 1855                 1860             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1865                 1870                 1875             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1880                 1885                 1890             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1895                 1900                 1905             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1910                 1915                 1920             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1925                 1930                 1935             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1940                 1945                 1950             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1955                 1960                 1965             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1970                 1975                 1980             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1985                 1990                 1995             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2000                 2005                 2010             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2015                 2020                 2025             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2030                 2035                 2040             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2045                 2050                 2055             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    2060                 2065                 2070             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    2075                 2080                 2085             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2090                 2095                 2100             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2105                 2110                 2115             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  222
<211>  4740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  222
atgaaacgga cagccgacgg aagcgagttc gagtcaccaa agaagaagcg gaaagtctct       60

gaagtcgagt ttagccacga gtattggatg aggcacgcac tgaccctggc aaagcgagca      120

tgggatgaaa gagaagtccc cgtgggcgcc gtgctggtgc acaacaatag agtgatcgga      180

gagggatgga acaggccaat cggccgccac gaccctaccg cacacgcaga gatcatggca      240

ctgaggcagg gaggcctggt catgcagaat taccgcctga tcgatgccac cctgtatgtg      300

acactggagc catgcgtgat gtgcgcagga gcaatgatcc acagcaggat cggaagagtg      360

gtgttcggag cacgggacgc caagaccggc gcagcaggct ccctgatgga tgtgctgcac      420

caccccggca tgaaccaccg ggtggagatc acagagggaa tcctggcaga cgagtgcgcc      480

gccctgctga gcgatttctt tagaatgcgg agacaggaga tcaaggccca gaagaaggca      540

cagagctcca ccgactctgg aggatctagc ggaggatcct ctggaagcga gacaccaggc      600

acaagcgagt ccgccacacc agagagctcc ggcggctcct ccggaggatc ctctgaggtg      660

gagttttccc acgagtactg gatgagacat gccctgaccc tggccaagag ggcacgggat      720

gagagggagg tgcctgtggg agccgtgctg gtgctgaaca atagagtgat cggcgagggc      780

tggaacagag ccatcggcct gcacgaccca acagcccatg ccgaaattat ggccctgaga      840

cagggcggcc tggtcatgca gaactacaga ctgattgacg ccaccctgta cgtgacattc      900

gagccttgcg tgatgtgcgc cggcgccatg atccactcta ggatcggccg cgtggtgttt      960

ggcgtgagga actcaaaaag aggcgccgca ggctccctga tgaacgtgct gaactacccc     1020

ggcatgaatc accgcgtcga aattaccgag ggaatcctgg cagatgaatg tgccgccctg     1080

ctgtgcgatt tctatcggat gcctagacag gtgttcaatg ctcagaagaa ggcccagagc     1140

tccatcaaca gtggtggaag tagcggaggc tcctctggct ctgagacacc tggcacaagc     1200

gagagcgcaa cacctgaaag cagcgggggc agcagcgggg ggtcagacaa gaagtacagc     1260

atcggcctgg ccatcggcac caactctgtg ggctgggccg tgatcaccga cgagtacaag     1320

gtgcccagca agaaattcaa ggtgctgggc aacaccgacc ggcacagcat caagaagaac     1380

ctgatcggag ccctgctgtt cgacagcggc gaaacagccg aggccacccg gctgaagaga     1440

accgccagaa gaagatacac cagacggaag aaccggatct gctatctgca agagatcttc     1500

agcaacgaga tggccaaggt ggacgacagc ttcttccaca gactggaaga gtccttcctg     1560

gtggaagagg ataagaagca cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg     1620

gcctaccacg agaagtaccc caccatctac cacctgagaa agaaactggt ggacagcacc     1680

gacaaggccg acctgcggct gatctatctg gccctggccc acatgatcaa gttccggggc     1740

cacttcctga tcgagggcga cctgaacccc gacaacagcg acgtggacaa gctgttcatc     1800

cagctggtgc agacctacaa ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg     1860

gacgccaagg ccatcctgtc tgccagactg agcaagagca gacggctgga aaatctgatc     1920

gcccagctgc ccggcgagaa gaagaatggc ctgttcggaa acctgattgc cctgagcctg     1980

ggcctgaccc ccaacttcaa gagcaacttc gacctggccg aggatgccaa actgcagctg     2040

agcaaggaca cctacgacga cgacctggac aacctgctgg cccagatcgg cgaccagtac     2100

gccgacctgt ttctggccgc caagaacctg tccgacgcca tcctgctgag cgacatcctg     2160

agagtgaaca ccgagatcac caaggccccc ctgagcgcct ctatgatcaa gagatacgac     2220

gagcaccacc aggacctgac cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag     2280

tacaaagaga ttttcttcga ccagagcaag aacggctacg ccggctacat tgacggcgga     2340

gccagccagg aagagttcta caagttcatc aagcccatcc tggaaaagat ggacggcacc     2400

gaggaactgc tcgtgaagct gaacagagag gacctgctgc ggaagcagcg gaccttcgac     2460

aacggcagca tcccccacca gatccacctg ggagagctgc acgccattct gcggcggcag     2520

gaagattttt acccattcct gaaggacaac cgggaaaaga tcgagaagat cctgaccttc     2580

cgcatcccct actacgtggg ccctctggcc aggggaaaca gcagattcgc ctggatgacc     2640

agaaagagcg aggaaaccat caccccctgg aacttcgagg aagtggtgga caagggcgct     2700

tccgcccaga gcttcatcga gcggatgacc aacttcgata agaacctgcc caacgagaag     2760

gtgctgccca agcacagcct gctgtacgag tacttcaccg tgtataacga gctgaccaaa     2820

gtgaaatacg tgaccgaggg aatgagaaag cccgccttcc tgagcggcga gcagaaaaag     2880

gccatcgtgg acctgctgtt caagaccaac cggaaagtga ccgtgaagca gctgaaagag     2940

gactacttca agaaaatcga ggacaagaag tacagcatcg gcctggccat cggcaccaac     3000

tctgtgggct gggccgtgat caccgacgag tacaaggtgc ccagcaagaa attcaaggtg     3060

ctgggcaaca ccgaccggca cagcatcaag aagaacctga tcggagccct gctgttcgac     3120

agcggcgaaa cagccgaggc cacccggctg aagagaaccg ccagaagaag atacaccaga     3180

cggaagaacc ggatctgcta tctgcaagag atcttcagca acgagatggc caaggtggac     3240

gacagcttct tccacagact ggaagagtcc ttcctggtgg aagaggataa gaagcacgag     3300

cggcacccca tcttcggcaa catcgtggac gaggtggcct accacgagaa gtaccccacc     3360

atctaccacc tgagaaagaa actggtggac agcaccgaca aggccgacct gcggctgatc     3420

tatctggccc tggcccacat gatcaagttc cggggccact tcctgatcga gggcgacctg     3480

aaccccgaca acagcgacgt ggacaagctg ttcatccagc tggtgcagac ctacaaccag     3540

ctgttcgagg aaaaccccat caacgccagc ggcgtggacg ccaaggccat cctgtctgcc     3600

agactgagca agagcagacg gctggaaaat ctgatcgccc agctgcccgg cgagaagaag     3660

aatggcctgt tcggaaacct gattgccctg agcctgggcc tgacccccaa cttcaagagc     3720

aacttcgacc tggccgagga tgccaaactg cagctgagca aggacaccta cgacgacgac     3780

ctggacaacc tgctggccca gatcggcgac cagtacgccg acctgtttct ggccgccaag     3840

aacctgtccg acgccatcct gctgagcgac atcctgagag tgaacaccga gatcaccaag     3900

gcccccctga gcgcctctat gatcaagaga tacgacgagc accaccagga cctgaccctg     3960

ctgaaagctc tcgtgcggca gcagctgcct gagaagtaca aagagatttt cttcgaccag     4020

agcaagaacg gctacgccgg ctacattgac ggcggagcca gccaggaaga gttctacaag     4080

ttcatcaagc ccatcctgga aaagatggac ggcaccgagg aactgctcgt gaagctgaac     4140

agagaggacc tgctgcggaa gcagcggacc ttcgacaacg gcagcatccc ccaccagatc     4200

cacctgggag agctgcacgc cattctgcgg cggcaggaag atttttaccc attcctgaag     4260

gacaaccggg aaaagatcga gaagatcctg accttccgca tcccctacta cgtgggccct     4320

ctggccaggg gaaacagcag attcgcctgg atgaccagaa agagcgagga aaccatcacc     4380

ccctggaact tcgaggaagt ggtggacaag ggcgcttccg cccagagctt catcgagcgg     4440

atgaccaact tcgataagaa cctgcccaac gagaaggtgc tgcccaagca cagcctgctg     4500

tacgagtact tcaccgtgta taacgagctg accaaagtga aatacgtgac cgagggaatg     4560

agaaagcccg ccttcctgag cggcgagcag aaaaaggcca tcgtggacct gctgttcaag     4620

accaaccgga aagtgaccgt gaagcagctg aaagaggact acttcaagaa aatcgagtct     4680

ggcggctcaa aaagaaccgc cgacggcagc gaattcgagc ccaagaagaa gaggaaagtc     4740


<210>  223
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  223

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  224
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  224

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  225
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  225

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  226
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  226

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  227
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  227

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  228
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  228

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  229
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  229

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  230
<211>  1824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  230

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met 
            20                  25                  30          


Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His 
        35                  40                  45              


Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser 
    50                  55                  60                  


Val Lys Met Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn 
65                  70                  75                  80  


Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp 
                85                  90                  95      


Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr 
            100                 105                 110         


Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu 
        115                 120                 125             


Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe 
    130                 135                 140                 


Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln 
145                 150                 155                 160 


Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu 
                165                 170                 175     


Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe 
            180                 185                 190         


Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg 
        195                 200                 205             


Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
        275                 280                 285             


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
                325                 330                 335     


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
            420                 425                 430         


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
        435                 440                 445             


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
        515                 520                 525             


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
545                 550                 555                 560 


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
            580                 585                 590         


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
    610                 615                 620                 


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
625                 630                 635                 640 


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                645                 650                 655     


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
            660                 665                 670         


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
        675                 680                 685             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    690                 695                 700                 


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
705                 710                 715                 720 


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
                725                 730                 735     


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
            740                 745                 750         


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
        755                 760                 765             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
    770                 775                 780                 


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
785                 790                 795                 800 


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
                805                 810                 815     


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
            820                 825                 830         


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
        835                 840                 845             


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
    850                 855                 860                 


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
865                 870                 875                 880 


Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val 
                885                 890                 895     


Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser 
            900                 905                 910         


Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile 
        915                 920                 925             


Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln 
    930                 935                 940                 


Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 
945                 950                 955                 960 


Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 
                965                 970                 975     


Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 
            980                 985                 990         


Val Asp Glu Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
        995                 1000                 1005             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1010                 1015                 1020             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1025                 1030                 1035             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1040                 1045                 1050             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1055                 1060                 1065             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1070                 1075                 1080             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1085                 1090                 1095             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1100                 1105                 1110             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1115                 1120                 1125             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1130                 1135                 1140             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1145                 1150                 1155             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1160                 1165                 1170             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1175                 1180                 1185             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1190                 1195                 1200             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1205                 1210                 1215             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1220                 1225                 1230             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1235                 1240                 1245             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1250                 1255                 1260             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1265                 1270                 1275             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1280                 1285                 1290             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1295                 1300                 1305             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1310                 1315                 1320             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1325                 1330                 1335             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1340                 1345                 1350             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1355                 1360                 1365             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1370                 1375                 1380             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1385                 1390                 1395             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1400                 1405                 1410             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1415                 1420                 1425             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1430                 1435                 1440             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1445                 1450                 1455             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1460                 1465                 1470             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1475                 1480                 1485             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1490                 1495                 1500             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1505                 1510                 1515             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1520                 1525                 1530             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1535                 1540                 1545             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1550                 1555                 1560             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1565                 1570                 1575             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1580                 1585                 1590             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1595                 1600                 1605             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Gly 
    1610                 1615                 1620             


Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1625                 1630                 1635             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1640                 1645                 1650             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1655                 1660                 1665             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1670                 1675                 1680             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1685                 1690                 1695             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly 
    1700                 1705                 1710             


Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu 
    1715                 1720                 1725             


Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met 
    1730                 1735                 1740             


Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser 
    1745                 1750                 1755             


Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn 
    1760                 1765                 1770             


Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala 
    1775                 1780                 1785             


Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu 
    1790                 1795                 1800             


Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro 
    1805                 1810                 1815             


Lys Lys  Lys Arg Lys Val 
    1820                 


<210>  231
<211>  2006
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  231

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg 
            20                  25                  30          


Asp Thr Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg 
        35                  40                  45              


Ser Tyr Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser 
    50                  55                  60                  


Asn Leu Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys 
65                  70                  75                  80  


Pro Gln Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn 
                85                  90                  95      


Gln Leu Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp 
            100                 105                 110         


Thr Pro Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu 
        115                 120                 125             


His Pro Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr 
    130                 135                 140                 


Trp Glu Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly 
145                 150                 155                 160 


Ala Arg Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu 
                165                 170                 175     


Asn Phe Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe 
            180                 185                 190         


Asp Glu Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg 
        195                 200                 205             


Tyr Leu Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro 
    210                 215                 220                 


Leu Val Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg 
225                 230                 235                 240 


Leu Asp Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu 
                245                 250                 255     


Cys Asn Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala 
            260                 265                 270         


Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala 
        275                 280                 285             


Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser 
    290                 295                 300                 


Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His 
305                 310                 315                 320 


Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu 
                325                 330                 335     


Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser 
            340                 345                 350         


Ile Met Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr 
        355                 360                 365             


Arg Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser 
    370                 375                 380                 


Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
                405                 410                 415     


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            420                 425                 430         


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
        435                 440                 445             


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
    450                 455                 460                 


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
465                 470                 475                 480 


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
                485                 490                 495     


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
            500                 505                 510         


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
        515                 520                 525             


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
    530                 535                 540                 


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
545                 550                 555                 560 


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
                565                 570                 575     


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
            580                 585                 590         


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
        595                 600                 605             


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
    610                 615                 620                 


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
625                 630                 635                 640 


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
                645                 650                 655     


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
            660                 665                 670         


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
        675                 680                 685             


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
    690                 695                 700                 


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
705                 710                 715                 720 


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
                725                 730                 735     


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
            740                 745                 750         


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
        755                 760                 765             


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
    770                 775                 780                 


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
785                 790                 795                 800 


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
                805                 810                 815     


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
            820                 825                 830         


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
        835                 840                 845             


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
    850                 855                 860                 


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
865                 870                 875                 880 


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
                885                 890                 895     


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
            900                 905                 910         


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
        915                 920                 925             


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
    930                 935                 940                 


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
945                 950                 955                 960 


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
                965                 970                 975     


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
            980                 985                 990         


Lys Gln Leu Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
        995                 1000                 1005             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1010                 1015                 1020             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1025                 1030                 1035             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1040                 1045                 1050             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1055                 1060                 1065             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1070                 1075                 1080             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1085                 1090                 1095             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1100                 1105                 1110             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1115                 1120                 1125             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1130                 1135                 1140             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1145                 1150                 1155             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1160                 1165                 1170             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1175                 1180                 1185             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1190                 1195                 1200             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1205                 1210                 1215             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1220                 1225                 1230             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1235                 1240                 1245             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1250                 1255                 1260             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1265                 1270                 1275             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1280                 1285                 1290             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1295                 1300                 1305             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1310                 1315                 1320             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1325                 1330                 1335             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1340                 1345                 1350             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1355                 1360                 1365             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1370                 1375                 1380             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1385                 1390                 1395             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1400                 1405                 1410             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1415                 1420                 1425             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1430                 1435                 1440             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1445                 1450                 1455             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1460                 1465                 1470             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1475                 1480                 1485             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1490                 1495                 1500             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1505                 1510                 1515             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1520                 1525                 1530             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1535                 1540                 1545             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1550                 1555                 1560             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1565                 1570                 1575             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1580                 1585                 1590             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1595                 1600                 1605             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1610                 1615                 1620             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1625                 1630                 1635             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1640                 1645                 1650             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1655                 1660                 1665             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1670                 1675                 1680             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    1685                 1690                 1695             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    1700                 1705                 1710             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    1715                 1720                 1725             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    1730                 1735                 1740             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    1745                 1750                 1755             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    1760                 1765                 1770             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1775                 1780                 1785             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    1790                 1795                 1800             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1805                 1810                 1815             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1820                 1825                 1830             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1835                 1840                 1845             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1850                 1855                 1860             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1865                 1870                 1875             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1880                 1885                 1890             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1895                 1900                 1905             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1910                 1915                 1920             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1925                 1930                 1935             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1940                 1945                 1950             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1955                 1960                 1965             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1970                 1975                 1980             


Met Leu  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1985                 1990                 1995             


Glu Pro  Lys Lys Lys Arg Lys  Val 
    2000                 2005     


<210>  232
<211>  2008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  232

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg 
            20                  25                  30          


Asp Thr Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg 
        35                  40                  45              


Asn Thr Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg 
    50                  55                  60                  


Pro Pro Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu 
65                  70                  75                  80  


Lys Tyr His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg 
                85                  90                  95      


Lys Leu His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp 
            100                 105                 110         


Ser Pro Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu 
        115                 120                 125             


Asp Pro Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe 
    130                 135                 140                 


Trp Asp Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg 
145                 150                 155                 160 


Asp Gly Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln 
                165                 170                 175     


His Cys Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro 
            180                 185                 190         


Trp Asn Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly 
        195                 200                 205             


Glu Ile Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe 
    210                 215                 220                 


Asn Asn Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr 
225                 230                 235                 240 


Glu Val Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg 
                245                 250                 255     


Arg Gly Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu 
            260                 265                 270         


Gly Arg His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys 
        275                 280                 285             


Leu Asp Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser 
    290                 295                 300                 


Pro Cys Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn 
305                 310                 315                 320 


Lys His Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln 
                325                 330                 335     


Gly Arg Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys 
            340                 345                 350         


Ile Ser Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe 
        355                 360                 365             


Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu 
    370                 375                 380                 


His Ser Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln 
385                 390                 395                 400 


Glu Asn Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
                405                 410                 415     


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
            420                 425                 430         


Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser 
        435                 440                 445             


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
    450                 455                 460                 


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
465                 470                 475                 480 


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
                485                 490                 495     


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
            500                 505                 510         


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
        515                 520                 525             


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
    530                 535                 540                 


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
545                 550                 555                 560 


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
                565                 570                 575     


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
            580                 585                 590         


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
        595                 600                 605             


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
    610                 615                 620                 


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
625                 630                 635                 640 


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
                645                 650                 655     


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
            660                 665                 670         


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
        675                 680                 685             


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
    690                 695                 700                 


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
705                 710                 715                 720 


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
                725                 730                 735     


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
            740                 745                 750         


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
        755                 760                 765             


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
    770                 775                 780                 


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
785                 790                 795                 800 


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
                805                 810                 815     


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
            820                 825                 830         


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
        835                 840                 845             


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
    850                 855                 860                 


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
865                 870                 875                 880 


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
                885                 890                 895     


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
            900                 905                 910         


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
        915                 920                 925             


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
    930                 935                 940                 


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
945                 950                 955                 960 


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
                965                 970                 975     


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
            980                 985                 990         


Thr Val Lys Gln Leu Lys Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe 
        995                 1000                 1005             


Asp Ser  Val Glu Ile Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser 
    1010                 1015                 1020             


Leu Gly  Thr Tyr His Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp 
    1025                 1030                 1035             


Phe Leu  Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
    1040                 1045                 1050             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1055                 1060                 1065             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1070                 1075                 1080             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1085                 1090                 1095             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1100                 1105                 1110             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1115                 1120                 1125             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1130                 1135                 1140             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1145                 1150                 1155             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1160                 1165                 1170             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1175                 1180                 1185             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1190                 1195                 1200             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1205                 1210                 1215             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1220                 1225                 1230             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1235                 1240                 1245             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1250                 1255                 1260             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1265                 1270                 1275             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1280                 1285                 1290             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1295                 1300                 1305             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1310                 1315                 1320             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1325                 1330                 1335             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1340                 1345                 1350             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1355                 1360                 1365             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1370                 1375                 1380             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1385                 1390                 1395             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1400                 1405                 1410             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1415                 1420                 1425             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1430                 1435                 1440             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1445                 1450                 1455             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1460                 1465                 1470             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1475                 1480                 1485             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1490                 1495                 1500             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1505                 1510                 1515             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1520                 1525                 1530             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1535                 1540                 1545             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1550                 1555                 1560             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1565                 1570                 1575             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1580                 1585                 1590             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1595                 1600                 1605             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1610                 1615                 1620             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1625                 1630                 1635             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1640                 1645                 1650             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1655                 1660                 1665             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1670                 1675                 1680             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1685                 1690                 1695             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1700                 1705                 1710             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1715                 1720                 1725             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1730                 1735                 1740             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1745                 1750                 1755             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1760                 1765                 1770             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1775                 1780                 1785             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1790                 1795                 1800             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1805                 1810                 1815             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1820                 1825                 1830             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1835                 1840                 1845             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1850                 1855                 1860             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1865                 1870                 1875             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1880                 1885                 1890             


Leu Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1895                 1900                 1905             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1910                 1915                 1920             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1925                 1930                 1935             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1940                 1945                 1950             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1955                 1960                 1965             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1970                 1975                 1980             


Ile Lys  Met Leu Ser Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser 
    1985                 1990                 1995             


Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    2000                 2005             


<210>  233
<211>  1822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  233

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln 
            20                  25                  30          


Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
        35                  40                  45              


Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe 
    50                  55                  60                  


Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu 
65                  70                  75                  80  


Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val 
                85                  90                  95      


Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val 
            100                 105                 110         


Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr 
        115                 120                 125             


Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu 
    130                 135                 140                 


Arg Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys 
145                 150                 155                 160 


Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr 
                165                 170                 175     


Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg 
            180                 185                 190         


Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg 
        195                 200                 205             


Asp Ala Phe Arg Thr Leu Gly Leu Ser Gly Gly Ser Ser Gly Gly Ser 
    210                 215                 220                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
225                 230                 235                 240 


Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu 
                245                 250                 255     


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            260                 265                 270         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        275                 280                 285             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    290                 295                 300                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
305                 310                 315                 320 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                325                 330                 335     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            340                 345                 350         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        355                 360                 365             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    370                 375                 380                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
385                 390                 395                 400 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                405                 410                 415     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            420                 425                 430         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        435                 440                 445             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    450                 455                 460                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
465                 470                 475                 480 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                485                 490                 495     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            500                 505                 510         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        515                 520                 525             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    530                 535                 540                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
545                 550                 555                 560 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                565                 570                 575     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            580                 585                 590         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        595                 600                 605             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    610                 615                 620                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
625                 630                 635                 640 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                645                 650                 655     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            660                 665                 670         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        675                 680                 685             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    690                 695                 700                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
705                 710                 715                 720 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                725                 730                 735     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            740                 745                 750         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        755                 760                 765             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    770                 775                 780                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
785                 790                 795                 800 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                805                 810                 815     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            820                 825                 830         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        835                 840                 845             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    850                 855                 860                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
865                 870                 875                 880 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                885                 890                 895     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            900                 905                 910         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        915                 920                 925             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    930                 935                 940                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
945                 950                 955                 960 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                965                 970                 975     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            980                 985                 990         


Glu Leu Val Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
        995                 1000                 1005             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1010                 1015                 1020             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1025                 1030                 1035             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1040                 1045                 1050             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1055                 1060                 1065             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1070                 1075                 1080             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1085                 1090                 1095             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1100                 1105                 1110             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1115                 1120                 1125             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1130                 1135                 1140             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1145                 1150                 1155             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1160                 1165                 1170             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1175                 1180                 1185             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1190                 1195                 1200             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1205                 1210                 1215             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1220                 1225                 1230             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1235                 1240                 1245             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1250                 1255                 1260             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1265                 1270                 1275             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1280                 1285                 1290             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1295                 1300                 1305             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1310                 1315                 1320             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1325                 1330                 1335             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1340                 1345                 1350             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1355                 1360                 1365             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1370                 1375                 1380             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1385                 1390                 1395             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1400                 1405                 1410             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1415                 1420                 1425             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1430                 1435                 1440             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1445                 1450                 1455             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1460                 1465                 1470             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1475                 1480                 1485             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1490                 1495                 1500             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1505                 1510                 1515             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1520                 1525                 1530             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1535                 1540                 1545             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1550                 1555                 1560             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1565                 1570                 1575             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1580                 1585                 1590             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1595                 1600                 1605             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1610                 1615                 1620             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1625                 1630                 1635             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1640                 1645                 1650             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1655                 1660                 1665             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1670                 1675                 1680             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1685                 1690                 1695             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1700                 1705                 1710             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1715                 1720                 1725             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1730                 1735                 1740             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1745                 1750                 1755             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1760                 1765                 1770             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1775                 1780                 1785             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1790                 1795                 1800             


Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys 
    1805                 1810                 1815             


Lys Arg  Lys Val 
    1820         


<210>  234
<211>  1832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  234

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp 
            20                  25                  30          


Ile Tyr Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser 
        35                  40                  45              


His Arg Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg 
    50                  55                  60                  


Ala Cys Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu 
65                  70                  75                  80  


Arg Gly Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr 
                85                  90                  95      


Leu Arg Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp 
            100                 105                 110         


Ser Pro Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln 
        115                 120                 125             


Glu Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu 
    130                 135                 140                 


Tyr Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg 
145                 150                 155                 160 


Asp Asn Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys 
                165                 170                 175     


Cys Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn 
            180                 185                 190         


Arg Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu 
        195                 200                 205             


Leu Ser Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro 
    210                 215                 220                 


Ala Val Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
                245                 250                 255     


Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser 
            260                 265                 270         


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
        275                 280                 285             


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
    290                 295                 300                 


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
305                 310                 315                 320 


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
                325                 330                 335     


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
            340                 345                 350         


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
        355                 360                 365             


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
    370                 375                 380                 


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
385                 390                 395                 400 


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
                405                 410                 415     


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
            420                 425                 430         


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
        435                 440                 445             


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
    450                 455                 460                 


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
465                 470                 475                 480 


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
                485                 490                 495     


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
            500                 505                 510         


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
        515                 520                 525             


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
    530                 535                 540                 


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
545                 550                 555                 560 


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
                565                 570                 575     


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
            580                 585                 590         


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
        595                 600                 605             


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
    610                 615                 620                 


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
625                 630                 635                 640 


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
                645                 650                 655     


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
            660                 665                 670         


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
        675                 680                 685             


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
    690                 695                 700                 


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
705                 710                 715                 720 


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
                725                 730                 735     


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
            740                 745                 750         


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
        755                 760                 765             


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
    770                 775                 780                 


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
785                 790                 795                 800 


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
                805                 810                 815     


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
            820                 825                 830         


Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu 
        835                 840                 845             


Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu 
    850                 855                 860                 


Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu 
865                 870                 875                 880 


Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr 
                885                 890                 895     


Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg 
            900                 905                 910         


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg 
        915                 920                 925             


Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly 
    930                 935                 940                 


Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr 
945                 950                 955                 960 


Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser 
                965                 970                 975     


Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
            980                 985                 990         


Gly Ile Leu Gln Thr Val Lys Val  Val Asp Glu Leu Val  Lys Val Met 
        995                 1000                 1005             


Gly Arg  His Lys Pro Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu 
    1010                 1015                 1020             


Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met 
    1025                 1030                 1035             


Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu 
    1040                 1045                 1050             


Lys Glu  His Pro Val Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu 
    1055                 1060                 1065             


Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
    1070                 1075                 1080             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1085                 1090                 1095             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1100                 1105                 1110             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1115                 1120                 1125             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1130                 1135                 1140             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1145                 1150                 1155             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1160                 1165                 1170             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1175                 1180                 1185             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1190                 1195                 1200             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1205                 1210                 1215             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1220                 1225                 1230             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1235                 1240                 1245             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1250                 1255                 1260             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1265                 1270                 1275             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1280                 1285                 1290             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1295                 1300                 1305             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1310                 1315                 1320             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1325                 1330                 1335             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1340                 1345                 1350             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1355                 1360                 1365             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1370                 1375                 1380             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1385                 1390                 1395             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1400                 1405                 1410             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1415                 1420                 1425             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1430                 1435                 1440             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1445                 1450                 1455             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1460                 1465                 1470             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1475                 1480                 1485             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1490                 1495                 1500             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1505                 1510                 1515             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1520                 1525                 1530             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1535                 1540                 1545             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1550                 1555                 1560             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1565                 1570                 1575             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1580                 1585                 1590             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1595                 1600                 1605             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1610                 1615                 1620             


Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1625                 1630                 1635             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1640                 1645                 1650             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1655                 1660                 1665             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1670                 1675                 1680             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1685                 1690                 1695             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1700                 1705                 1710             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser 
    1715                 1720                 1725             


Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu 
    1730                 1735                 1740             


Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu 
    1745                 1750                 1755             


Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile Leu Val  His Thr Ala 
    1760                 1765                 1770             


Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp 
    1775                 1780                 1785             


Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn 
    1790                 1795                 1800             


Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly Gly Ser  Lys Arg Thr 
    1805                 1810                 1815             


Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys Lys Arg  Lys Val 
    1820                 1825                 1830         


<210>  235
<211>  1786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  235

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Phe Glu Arg Asn Tyr Asp Pro Arg Glu Leu Arg Lys Glu 
            20                  25                  30          


Thr Tyr Leu Leu Tyr Glu Ile Lys Trp Gly Lys Ser Gly Lys Leu Trp 
        35                  40                  45              


Arg His Trp Cys Gln Asn Asn Arg Thr Gln His Ala Glu Val Tyr Phe 
    50                  55                  60                  


Leu Glu Asn Ile Phe Asn Ala Arg Arg Phe Asn Pro Ser Thr His Cys 
65                  70                  75                  80  


Ser Ile Thr Trp Tyr Leu Ser Trp Ser Pro Cys Ala Glu Cys Ser Gln 
                85                  90                  95      


Lys Ile Val Asp Phe Leu Lys Glu His Pro Asn Val Asn Leu Glu Ile 
            100                 105                 110         


Tyr Val Ala Arg Leu Tyr Tyr His Glu Asp Glu Arg Asn Arg Gln Gly 
        115                 120                 125             


Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Arg Ile Met Asp Leu 
    130                 135                 140                 


Pro Asp Tyr Asn Tyr Cys Trp Lys Thr Phe Val Ser Asp Gln Gly Gly 
145                 150                 155                 160 


Asp Glu Asp Tyr Trp Pro Gly His Phe Ala Pro Trp Ile Lys Gln Tyr 
                165                 170                 175     


Ser Leu Lys Leu Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
            180                 185                 190         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
        195                 200                 205             


Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
    210                 215                 220                 


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
225                 230                 235                 240 


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
                245                 250                 255     


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
            260                 265                 270         


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
        275                 280                 285             


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
    290                 295                 300                 


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
305                 310                 315                 320 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
                325                 330                 335     


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
            340                 345                 350         


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
        355                 360                 365             


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
    370                 375                 380                 


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
385                 390                 395                 400 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
                405                 410                 415     


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
            420                 425                 430         


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
        435                 440                 445             


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
    450                 455                 460                 


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
                485                 490                 495     


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
            500                 505                 510         


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
        515                 520                 525             


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
    530                 535                 540                 


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
545                 550                 555                 560 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
                565                 570                 575     


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
            580                 585                 590         


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
        595                 600                 605             


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
    610                 615                 620                 


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
625                 630                 635                 640 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
                645                 650                 655     


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
            660                 665                 670         


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
        675                 680                 685             


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
    690                 695                 700                 


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
705                 710                 715                 720 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
                725                 730                 735     


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
            740                 745                 750         


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
        755                 760                 765             


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
    770                 775                 780                 


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
785                 790                 795                 800 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
                805                 810                 815     


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
            820                 825                 830         


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
        835                 840                 845             


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
    850                 855                 860                 


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
865                 870                 875                 880 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
                885                 890                 895     


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
            900                 905                 910         


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
        915                 920                 925             


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
    930                 935                 940                 


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
945                 950                 955                 960 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
                965                 970                 975     


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
            980                 985                 990         


Lys Arg Ile Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
        995                 1000                 1005             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1010                 1015                 1020             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1025                 1030                 1035             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1040                 1045                 1050             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1055                 1060                 1065             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1070                 1075                 1080             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1085                 1090                 1095             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1100                 1105                 1110             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1115                 1120                 1125             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1130                 1135                 1140             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1145                 1150                 1155             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1160                 1165                 1170             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1175                 1180                 1185             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1190                 1195                 1200             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1205                 1210                 1215             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1220                 1225                 1230             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1235                 1240                 1245             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1250                 1255                 1260             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1265                 1270                 1275             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1280                 1285                 1290             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1295                 1300                 1305             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1310                 1315                 1320             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1325                 1330                 1335             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1340                 1345                 1350             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1355                 1360                 1365             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1370                 1375                 1380             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1385                 1390                 1395             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1400                 1405                 1410             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1415                 1420                 1425             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1430                 1435                 1440             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1445                 1450                 1455             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1460                 1465                 1470             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1475                 1480                 1485             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1490                 1495                 1500             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1505                 1510                 1515             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1520                 1525                 1530             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1535                 1540                 1545             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1550                 1555                 1560             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1565                 1570                 1575             


Asp Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1580                 1585                 1590             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1595                 1600                 1605             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1610                 1615                 1620             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1625                 1630                 1635             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1640                 1645                 1650             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1655                 1660                 1665             


Ile Lys  Met Leu Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1670                 1675                 1680             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1685                 1690                 1695             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1700                 1705                 1710             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1715                 1720                 1725             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1730                 1735                 1740             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1745                 1750                 1755             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1760                 1765                 1770             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1775                 1780                 1785     


<210>  236
<211>  1823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  236

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp 
            20                  25                  30          


Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys 
        35                  40                  45              


Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val 
    50                  55                  60                  


Lys Met Asp Gln His Arg Gly Phe Leu His Gly Gln Ala Lys Asn Leu 
65                  70                  75                  80  


Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu 
                85                  90                  95      


Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp 
            100                 105                 110         


Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val 
        115                 120                 125             


Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala 
    130                 135                 140                 


Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met 
145                 150                 155                 160 


Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe 
                165                 170                 175     


Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln 
            180                 185                 190         


Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu 
        195                 200                 205             


Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
225                 230                 235                 240 


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
                245                 250                 255     


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            260                 265                 270         


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        275                 280                 285             


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    290                 295                 300                 


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
305                 310                 315                 320 


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                325                 330                 335     


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            340                 345                 350         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        355                 360                 365             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    370                 375                 380                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
385                 390                 395                 400 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                405                 410                 415     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            420                 425                 430         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        435                 440                 445             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    450                 455                 460                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
465                 470                 475                 480 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                485                 490                 495     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            500                 505                 510         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        515                 520                 525             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    530                 535                 540                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
545                 550                 555                 560 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                565                 570                 575     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            580                 585                 590         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        595                 600                 605             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    610                 615                 620                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
625                 630                 635                 640 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                645                 650                 655     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            660                 665                 670         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        675                 680                 685             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    690                 695                 700                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
705                 710                 715                 720 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                725                 730                 735     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            740                 745                 750         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        755                 760                 765             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    770                 775                 780                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
785                 790                 795                 800 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                805                 810                 815     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            820                 825                 830         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        835                 840                 845             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    850                 855                 860                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
865                 870                 875                 880 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                885                 890                 895     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            900                 905                 910         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        915                 920                 925             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    930                 935                 940                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
945                 950                 955                 960 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                965                 970                 975     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            980                 985                 990         


Asp Glu Leu Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
        995                 1000                 1005             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1010                 1015                 1020             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1025                 1030                 1035             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1040                 1045                 1050             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1055                 1060                 1065             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1070                 1075                 1080             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1085                 1090                 1095             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1100                 1105                 1110             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1115                 1120                 1125             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1130                 1135                 1140             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1145                 1150                 1155             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1160                 1165                 1170             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1175                 1180                 1185             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1190                 1195                 1200             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1205                 1210                 1215             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1220                 1225                 1230             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1235                 1240                 1245             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1250                 1255                 1260             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1265                 1270                 1275             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1280                 1285                 1290             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1295                 1300                 1305             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1310                 1315                 1320             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1325                 1330                 1335             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1340                 1345                 1350             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1355                 1360                 1365             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1370                 1375                 1380             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1385                 1390                 1395             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1400                 1405                 1410             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1415                 1420                 1425             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1430                 1435                 1440             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1445                 1450                 1455             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1460                 1465                 1470             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1475                 1480                 1485             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1490                 1495                 1500             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1505                 1510                 1515             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1520                 1525                 1530             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1535                 1540                 1545             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1550                 1555                 1560             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1565                 1570                 1575             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1580                 1585                 1590             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1595                 1600                 1605             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1610                 1615                 1620             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1625                 1630                 1635             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1640                 1645                 1650             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1655                 1660                 1665             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1670                 1675                 1680             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1685                 1690                 1695             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1700                 1705                 1710             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1715                 1720                 1725             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1730                 1735                 1740             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1745                 1750                 1755             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1760                 1765                 1770             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1775                 1780                 1785             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1790                 1795                 1800             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1805                 1810                 1815             


Lys Lys  Arg Lys Val 
    1820             


<210>  237
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  237

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His Leu Ala Asn Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  238
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  238

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  239
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  239

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  240
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  240

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  241
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  241

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  242
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  242

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  243
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  243

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  244
<211>  1874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  244

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala Thr Ala Lys Tyr 
        275                 280                 285             


Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 
    290                 295                 300                 


Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 
305                 310                 315                 320 


Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 
                325                 330                 335     


Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 
            340                 345                 350         


Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 
        355                 360                 365             


Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 
    370                 375                 380                 


Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 
385                 390                 395                 400 


Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu 
                405                 410                 415     


Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp 
            420                 425                 430         


Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile 
        435                 440                 445             


Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 
    450                 455                 460                 


Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu 
465                 470                 475                 480 


Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 
                485                 490                 495     


Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 
            500                 505                 510         


Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 
        515                 520                 525             


Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 
    530                 535                 540                 


Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 
545                 550                 555                 560 


Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 
                565                 570                 575     


Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys 
            580                 585                 590         


Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr 
        595                 600                 605             


Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
                645                 650                 655     


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            660                 665                 670         


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        675                 680                 685             


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    690                 695                 700                 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
705                 710                 715                 720 


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                725                 730                 735     


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            740                 745                 750         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        755                 760                 765             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    770                 775                 780                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
785                 790                 795                 800 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                805                 810                 815     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            820                 825                 830         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        835                 840                 845             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    850                 855                 860                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
865                 870                 875                 880 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                885                 890                 895     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            900                 905                 910         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        915                 920                 925             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    930                 935                 940                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
945                 950                 955                 960 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                965                 970                 975     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            980                 985                 990         


Asp Gln Ser Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
        995                 1000                 1005             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1010                 1015                 1020             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1025                 1030                 1035             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1040                 1045                 1050             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1055                 1060                 1065             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1070                 1075                 1080             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1085                 1090                 1095             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1100                 1105                 1110             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1115                 1120                 1125             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1130                 1135                 1140             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1145                 1150                 1155             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1160                 1165                 1170             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1175                 1180                 1185             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1190                 1195                 1200             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1205                 1210                 1215             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1220                 1225                 1230             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1235                 1240                 1245             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1250                 1255                 1260             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1265                 1270                 1275             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1280                 1285                 1290             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1295                 1300                 1305             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1310                 1315                 1320             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1325                 1330                 1335             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1340                 1345                 1350             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1355                 1360                 1365             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1370                 1375                 1380             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1385                 1390                 1395             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1400                 1405                 1410             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1415                 1420                 1425             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1430                 1435                 1440             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1445                 1450                 1455             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1460                 1465                 1470             


Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys 
    1475                 1480                 1485             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1490                 1495                 1500             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1505                 1510                 1515             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1520                 1525                 1530             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1535                 1540                 1545             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1550                 1555                 1560             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1565                 1570                 1575             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1580                 1585                 1590             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1595                 1600                 1605             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1610                 1615                 1620             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1625                 1630                 1635             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1640                 1645                 1650             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Ser 
    1655                 1660                 1665             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1670                 1675                 1680             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1685                 1690                 1695             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1700                 1705                 1710             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1715                 1720                 1725             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1730                 1735                 1740             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1745                 1750                 1755             


Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1760                 1765                 1770             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1775                 1780                 1785             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1790                 1795                 1800             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1805                 1810                 1815             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1820                 1825                 1830             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1835                 1840                 1845             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    1850                 1855                 1860             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1865                 1870                 


<210>  245
<211>  1874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  245

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala Thr Ala Lys Tyr 
        275                 280                 285             


Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 
    290                 295                 300                 


Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 
305                 310                 315                 320 


Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 
                325                 330                 335     


Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 
            340                 345                 350         


Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 
        355                 360                 365             


Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 
    370                 375                 380                 


Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 
385                 390                 395                 400 


Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu 
                405                 410                 415     


Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp 
            420                 425                 430         


Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile 
        435                 440                 445             


Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 
    450                 455                 460                 


Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu 
465                 470                 475                 480 


Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 
                485                 490                 495     


Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 
            500                 505                 510         


Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 
        515                 520                 525             


Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 
    530                 535                 540                 


Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 
545                 550                 555                 560 


Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 
                565                 570                 575     


Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys 
            580                 585                 590         


Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr 
        595                 600                 605             


Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
                645                 650                 655     


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            660                 665                 670         


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        675                 680                 685             


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    690                 695                 700                 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
705                 710                 715                 720 


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                725                 730                 735     


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            740                 745                 750         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        755                 760                 765             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    770                 775                 780                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
785                 790                 795                 800 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                805                 810                 815     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            820                 825                 830         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        835                 840                 845             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    850                 855                 860                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
865                 870                 875                 880 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                885                 890                 895     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            900                 905                 910         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        915                 920                 925             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    930                 935                 940                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
945                 950                 955                 960 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                965                 970                 975     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            980                 985                 990         


Asp Gln Ser Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
        995                 1000                 1005             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1010                 1015                 1020             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1025                 1030                 1035             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1040                 1045                 1050             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1055                 1060                 1065             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1070                 1075                 1080             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1085                 1090                 1095             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1100                 1105                 1110             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1115                 1120                 1125             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1130                 1135                 1140             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1145                 1150                 1155             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1160                 1165                 1170             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1175                 1180                 1185             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1190                 1195                 1200             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1205                 1210                 1215             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1220                 1225                 1230             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1235                 1240                 1245             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1250                 1255                 1260             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1265                 1270                 1275             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1280                 1285                 1290             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1295                 1300                 1305             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1310                 1315                 1320             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1325                 1330                 1335             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1340                 1345                 1350             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1355                 1360                 1365             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1370                 1375                 1380             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1385                 1390                 1395             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1400                 1405                 1410             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1415                 1420                 1425             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1430                 1435                 1440             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1445                 1450                 1455             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1460                 1465                 1470             


Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys 
    1475                 1480                 1485             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1490                 1495                 1500             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1505                 1510                 1515             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1520                 1525                 1530             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1535                 1540                 1545             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1550                 1555                 1560             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1565                 1570                 1575             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1580                 1585                 1590             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1595                 1600                 1605             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1610                 1615                 1620             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1625                 1630                 1635             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1640                 1645                 1650             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Ser 
    1655                 1660                 1665             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1670                 1675                 1680             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1685                 1690                 1695             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1700                 1705                 1710             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1715                 1720                 1725             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1730                 1735                 1740             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1745                 1750                 1755             


Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1760                 1765                 1770             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1775                 1780                 1785             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1790                 1795                 1800             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1805                 1810                 1815             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1820                 1825                 1830             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1835                 1840                 1845             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    1850                 1855                 1860             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1865                 1870                 


<210>  246
<211>  1874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  246

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala Thr Ala Lys Tyr 
        275                 280                 285             


Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 
    290                 295                 300                 


Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 
305                 310                 315                 320 


Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 
                325                 330                 335     


Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 
            340                 345                 350         


Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 
        355                 360                 365             


Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 
    370                 375                 380                 


Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 
385                 390                 395                 400 


Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu 
                405                 410                 415     


Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp 
            420                 425                 430         


Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile 
        435                 440                 445             


Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 
    450                 455                 460                 


Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu 
465                 470                 475                 480 


Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 
                485                 490                 495     


Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 
            500                 505                 510         


Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 
        515                 520                 525             


Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 
    530                 535                 540                 


Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 
545                 550                 555                 560 


Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 
                565                 570                 575     


Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys 
            580                 585                 590         


Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr 
        595                 600                 605             


Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
                645                 650                 655     


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            660                 665                 670         


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        675                 680                 685             


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    690                 695                 700                 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
705                 710                 715                 720 


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                725                 730                 735     


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            740                 745                 750         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        755                 760                 765             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    770                 775                 780                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
785                 790                 795                 800 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                805                 810                 815     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            820                 825                 830         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        835                 840                 845             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    850                 855                 860                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
865                 870                 875                 880 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                885                 890                 895     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            900                 905                 910         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        915                 920                 925             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    930                 935                 940                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
945                 950                 955                 960 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                965                 970                 975     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            980                 985                 990         


Asp Gln Ser Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
        995                 1000                 1005             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1010                 1015                 1020             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1025                 1030                 1035             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1040                 1045                 1050             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1055                 1060                 1065             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1070                 1075                 1080             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1085                 1090                 1095             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1100                 1105                 1110             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1115                 1120                 1125             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1130                 1135                 1140             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1145                 1150                 1155             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1160                 1165                 1170             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1175                 1180                 1185             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1190                 1195                 1200             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1205                 1210                 1215             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1220                 1225                 1230             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1235                 1240                 1245             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1250                 1255                 1260             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1265                 1270                 1275             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1280                 1285                 1290             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1295                 1300                 1305             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1310                 1315                 1320             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1325                 1330                 1335             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1340                 1345                 1350             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1355                 1360                 1365             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1370                 1375                 1380             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1385                 1390                 1395             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1400                 1405                 1410             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1415                 1420                 1425             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1430                 1435                 1440             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1445                 1450                 1455             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1460                 1465                 1470             


Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys 
    1475                 1480                 1485             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1490                 1495                 1500             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1505                 1510                 1515             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1520                 1525                 1530             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1535                 1540                 1545             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1550                 1555                 1560             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1565                 1570                 1575             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1580                 1585                 1590             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1595                 1600                 1605             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1610                 1615                 1620             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1625                 1630                 1635             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1640                 1645                 1650             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Ser 
    1655                 1660                 1665             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1670                 1675                 1680             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1685                 1690                 1695             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1700                 1705                 1710             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1715                 1720                 1725             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1730                 1735                 1740             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1745                 1750                 1755             


Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1760                 1765                 1770             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1775                 1780                 1785             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1790                 1795                 1800             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1805                 1810                 1815             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1820                 1825                 1830             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1835                 1840                 1845             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    1850                 1855                 1860             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1865                 1870                 


<210>  247
<211>  1874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  247

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala Thr Ala Lys Tyr 
        275                 280                 285             


Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 
    290                 295                 300                 


Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 
305                 310                 315                 320 


Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 
                325                 330                 335     


Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 
            340                 345                 350         


Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 
        355                 360                 365             


Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 
    370                 375                 380                 


Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 
385                 390                 395                 400 


Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu 
                405                 410                 415     


Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp 
            420                 425                 430         


Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile 
        435                 440                 445             


Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 
    450                 455                 460                 


Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu 
465                 470                 475                 480 


Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 
                485                 490                 495     


Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 
            500                 505                 510         


Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 
        515                 520                 525             


Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 
    530                 535                 540                 


Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 
545                 550                 555                 560 


Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 
                565                 570                 575     


Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys 
            580                 585                 590         


Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr 
        595                 600                 605             


Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
                645                 650                 655     


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            660                 665                 670         


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        675                 680                 685             


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    690                 695                 700                 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
705                 710                 715                 720 


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                725                 730                 735     


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            740                 745                 750         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        755                 760                 765             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    770                 775                 780                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
785                 790                 795                 800 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                805                 810                 815     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            820                 825                 830         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        835                 840                 845             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    850                 855                 860                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
865                 870                 875                 880 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                885                 890                 895     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            900                 905                 910         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        915                 920                 925             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    930                 935                 940                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
945                 950                 955                 960 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                965                 970                 975     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            980                 985                 990         


Asp Gln Ser Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
        995                 1000                 1005             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1010                 1015                 1020             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1025                 1030                 1035             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1040                 1045                 1050             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1055                 1060                 1065             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1070                 1075                 1080             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1085                 1090                 1095             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1100                 1105                 1110             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1115                 1120                 1125             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1130                 1135                 1140             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1145                 1150                 1155             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1160                 1165                 1170             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1175                 1180                 1185             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1190                 1195                 1200             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1205                 1210                 1215             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1220                 1225                 1230             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1235                 1240                 1245             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1250                 1255                 1260             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1265                 1270                 1275             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1280                 1285                 1290             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1295                 1300                 1305             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1310                 1315                 1320             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1325                 1330                 1335             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1340                 1345                 1350             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1355                 1360                 1365             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1370                 1375                 1380             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1385                 1390                 1395             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1400                 1405                 1410             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1415                 1420                 1425             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1430                 1435                 1440             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1445                 1450                 1455             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1460                 1465                 1470             


Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys 
    1475                 1480                 1485             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1490                 1495                 1500             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1505                 1510                 1515             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1520                 1525                 1530             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1535                 1540                 1545             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1550                 1555                 1560             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1565                 1570                 1575             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1580                 1585                 1590             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1595                 1600                 1605             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1610                 1615                 1620             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1625                 1630                 1635             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1640                 1645                 1650             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Ser 
    1655                 1660                 1665             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1670                 1675                 1680             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1685                 1690                 1695             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1700                 1705                 1710             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1715                 1720                 1725             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1730                 1735                 1740             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1745                 1750                 1755             


Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1760                 1765                 1770             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1775                 1780                 1785             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1790                 1795                 1800             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1805                 1810                 1815             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1820                 1825                 1830             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1835                 1840                 1845             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    1850                 1855                 1860             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1865                 1870                 


<210>  248
<211>  1874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  248

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala Thr Ala Lys Tyr 
        275                 280                 285             


Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 
    290                 295                 300                 


Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 
305                 310                 315                 320 


Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 
                325                 330                 335     


Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 
            340                 345                 350         


Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 
        355                 360                 365             


Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 
    370                 375                 380                 


Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 
385                 390                 395                 400 


Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu 
                405                 410                 415     


Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp 
            420                 425                 430         


Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile 
        435                 440                 445             


Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 
    450                 455                 460                 


Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu 
465                 470                 475                 480 


Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 
                485                 490                 495     


Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 
            500                 505                 510         


Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 
        515                 520                 525             


Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 
    530                 535                 540                 


Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 
545                 550                 555                 560 


Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 
                565                 570                 575     


Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys 
            580                 585                 590         


Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr 
        595                 600                 605             


Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
                645                 650                 655     


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            660                 665                 670         


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        675                 680                 685             


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    690                 695                 700                 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
705                 710                 715                 720 


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                725                 730                 735     


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            740                 745                 750         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        755                 760                 765             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    770                 775                 780                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
785                 790                 795                 800 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                805                 810                 815     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            820                 825                 830         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        835                 840                 845             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    850                 855                 860                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
865                 870                 875                 880 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                885                 890                 895     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            900                 905                 910         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        915                 920                 925             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    930                 935                 940                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
945                 950                 955                 960 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                965                 970                 975     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            980                 985                 990         


Asp Gln Ser Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
        995                 1000                 1005             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1010                 1015                 1020             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1025                 1030                 1035             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1040                 1045                 1050             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1055                 1060                 1065             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1070                 1075                 1080             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1085                 1090                 1095             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1100                 1105                 1110             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1115                 1120                 1125             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1130                 1135                 1140             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1145                 1150                 1155             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1160                 1165                 1170             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1175                 1180                 1185             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1190                 1195                 1200             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1205                 1210                 1215             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1220                 1225                 1230             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1235                 1240                 1245             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1250                 1255                 1260             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1265                 1270                 1275             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1280                 1285                 1290             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1295                 1300                 1305             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1310                 1315                 1320             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1325                 1330                 1335             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1340                 1345                 1350             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1355                 1360                 1365             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1370                 1375                 1380             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1385                 1390                 1395             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1400                 1405                 1410             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1415                 1420                 1425             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1430                 1435                 1440             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1445                 1450                 1455             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1460                 1465                 1470             


Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys 
    1475                 1480                 1485             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1490                 1495                 1500             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1505                 1510                 1515             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1520                 1525                 1530             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1535                 1540                 1545             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1550                 1555                 1560             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1565                 1570                 1575             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1580                 1585                 1590             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1595                 1600                 1605             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1610                 1615                 1620             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1625                 1630                 1635             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1640                 1645                 1650             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Ser 
    1655                 1660                 1665             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1670                 1675                 1680             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1685                 1690                 1695             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1700                 1705                 1710             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1715                 1720                 1725             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1730                 1735                 1740             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1745                 1750                 1755             


Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1760                 1765                 1770             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1775                 1780                 1785             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1790                 1795                 1800             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1805                 1810                 1815             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1820                 1825                 1830             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1835                 1840                 1845             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    1850                 1855                 1860             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1865                 1870                 


<210>  249
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  249
ggtttcagac aaaatcaaaa agaaggaagg tgctcacatt ccttaaatta a                51


<210>  250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  250
auuuugucua aaacccugua                                                   20


<210>  251
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  251
ggttttagac aaaatcaaaa agaaggaagg tgctcacatt ccttaaatta a                51


<210>  252
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  252
attttcctta cagggtttta                                                   20


<210>  253
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  253
tttccttaca gggttttaga                                                   20


<210>  254
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  254
ttccttacag ggttttagac                                                   20


<210>  255
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  255
tccttacagg gttttagaca                                                   20


<210>  256
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  256
ccttacaggg ttttagacaa                                                   20


<210>  257
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  257
cttacagggt tttagacaaa                                                   20


<210>  258
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  258
ttacagggtt ttagacaaaa                                                   20


<210>  259
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  259
tacagggttt tagacaaaat                                                   20


<210>  260
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  260
acagggtttt agacaaaatc                                                   20


<210>  261
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  261
gttttagaca aaatc                                                        15


<210>  262
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  262
ggttttagac aaaatca                                                      17


<210>  263
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  263
gggttttaga caaaatcaa                                                    19


<210>  264
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  264
agggttttag acaaaatcaa a                                                 21


<210>  265
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  265
cagggtttta gacaaaatca aaa                                               23


<210>  266
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  266
acagggtttt agacaaaatc aaaa                                              24


<210>  267
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  267
catagagcag cactaaatg                                                    19


<210>  268
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  268
atagagcagc actaaatga                                                    19


<210>  269
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  269
tagagcagca ctaaatgac                                                    19


<210>  270
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  270
agagcagcac taaatgaca                                                    19


<210>  271
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  271
gagcagcact aaatgacac                                                    19


<210>  272
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  272
agcagcacta aatgacacc                                                    19


<210>  273
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  273
gcagcactaa atgacacca                                                    19


<210>  274
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  274
cagcactaaa tgacaccat                                                    19


<210>  275
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  275
agcactaaat gacaccata                                                    19


<210>  276
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  276
gcactaaatg acaccataa                                                    19


<210>  277
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  277
taaatgacac cataa                                                        15


<210>  278
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  278
ctaaatgaca ccataaa                                                      17


<210>  279
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  279
actaaatgac accataaag                                                    19


<210>  280
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  280
cactaaatga caccataaag a                                                 21


<210>  281
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  281
gcactaaatg acaccataaa gaa                                               23


<210>  282
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  282
agcactaaat gacaccataa agaaa                                             25


<210>  283
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  283
aatttcatgg tacatgagtg                                                   20


<210>  284
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  284
tttcatggta catgagtggc                                                   20


<210>  285
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  285
ttcatggtac atgagtggct                                                   20


<210>  286
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  286
tcatggtaca tgagtggcta                                                   20


<210>  287
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  287
catggtacat gagtggctat                                                   20


<210>  288
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  288
atggtacatg agtggctatc                                                   20


<210>  289
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  289
tggtacatga gtggctatca                                                   20


<210>  290
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  290
ggtacatgag tggctatcat                                                   20


<210>  291
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  291
gtacatgagt ggctatcata                                                   20


<210>  292
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  292
tgagtggcta tcata                                                        15


<210>  293
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  293
atgagtggct atcatac                                                      17


<210>  294
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  294
catgagtggc tatcatact                                                    19


<210>  295
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  295
acatgagtgg ctatcatact g                                                 21


<210>  296
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  296
tacatgagtg gctatcatac tgg                                               23


<210>  297
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  n is a, c, g, or t

<400>  297
nnnnnnnngt ttttgtactc tcaagattta gaaataaatc ttgcagaagc tacaaagata       60

aggcttcatg ccgaaatcaa caccctgtca ttttatggca gggtgttttc gttatttaat      120

ttttt                                                                  125


<210>  298
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  n is a, c, g, or t

<400>  298
nnnnnnnnnn nnnnnnnngt ttttgtactc tcagaaatgc agaagctaca aagataaggc       60

ttcatgccga aatcaacacc ctgtcatttt atggcagggt gttttcgtta tttaattttt      120

t                                                                      121


<210>  299
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  299
nnnnnnnnnn nnnnnnnnnn gtttttgtac tctcagaaat gcagaagcta caaagataag       60

gcttcatgcc gaaatcaaca ccctgtcatt ttatggcagg gtgtttttt                  109


<210>  300
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  300
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  301
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  301
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gttttttt                                          88


<210>  302
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  302
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcatt tttttt                                                       76


<210>  303
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  303
guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu ccguuaucaa cuugaaaaag       60

uggcaccgag ucggugcuuu uu                                                82


<210>  304
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  304
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uuu                                               83


<210>  305
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  305
gguccaccca ccugggcucc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uuu                        103


<210>  306
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  306
uuuuugauuu ugucuaaaac ccugua                                            26


<210>  307
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  307
uuuugauuuu gucuaaaacc cugua                                             25


<210>  308
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  308
uuugauuuug ucuaaaaccc ugua                                              24


<210>  309
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  309
uugauuuugu cuaaaacccu gua                                               23


<210>  310
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  310
ugauuuuguc uaaaacccug ua                                                22


<210>  311
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  311
gauuuugucu aaaacccugu a                                                 21


<210>  312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  312
auuuugucua aaacccugua                                                   20


<210>  313
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  313
uuuugucuaa aacccugua                                                    19


<210>  314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  314
uuugucuaaa acccugua                                                     18


<210>  315
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  315
uugucuaaaa cccugua                                                      17


<210>  316
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  316
ugucuaaaac ccugua                                                       16


<210>  317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  317
uuugucuaaa acccuguaag                                                   20


<210>  318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  318
uuuugucuaa aacccuguaa                                                   20


<210>  319
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  319
ugauuuuguc uaaaaccc                                                     18


<210>  320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  320
gauuuugucu aaaacccu                                                     18


<210>  321
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  321
auuuugucua aaacccug                                                     18


<210>  322
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  322
gucuaaaacc cuguaagg                                                     18


<210>  323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  323
ucuaaaaccc uguaagga                                                     18


<210>  324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  324
uuugcaggaa augcuggcau                                                   20


<210>  325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  325
uucucauuug caggaaaugc                                                   20


<210>  326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  326
cauuuagugc ugcucuaugc                                                   20


<210>  327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  327
caggaaaugc uggcauagag                                                   20


<210>  328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  328
uugcaggaaa ugcuggcaua                                                   20


<210>  329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  329
auuugcagga aaugcuggca                                                   20


<210>  330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  330
uacaugagug gcuaucauac                                                   20


<210>  331
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  331
attttgtcta aaaccctgta                                                   20


<210>  332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  332
auuuugucua aaacccugua                                                   20


<210>  333
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  333
tttgtctaaa accctgtaag                                                   20


<210>  334
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  334
ttttgtctaa aaccctgtaa                                                   20


<210>  335
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  335
tgattttgtc taaaaccc                                                     18


<210>  336
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  336
gattttgtct aaaaccct                                                     18


<210>  337
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  337
attttgtcta aaaccctg                                                     18


<210>  338
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  338
gtctaaaacc ctgtaagg                                                     18


<210>  339
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  339
tctaaaaccc tgtaagga                                                     18


<210>  340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  340
uuugucuaaa acccuguaag                                                   20


<210>  341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  341
uuuugucuaa aacccuguaa                                                   20


<210>  342
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  342
ugauuuuguc uaaaaccc                                                     18


<210>  343
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  343
gauuuugucu aaaacccu                                                     18


<210>  344
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  344
auuuugucua aaacccug                                                     18


<210>  345
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  345
gucuaaaacc cuguaagg                                                     18


<210>  346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  346
ucuaaaaccc uguaagga                                                     18


<210>  347
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  347
tttgcaggaa atgctggcat                                                   20


<210>  348
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  348
ttctcatttg caggaaatgc                                                   20


<210>  349
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  349
catttagtgc tgctctatgc                                                   20


<210>  350
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  350
caggaaatgc tggcatagag                                                   20


<210>  351
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  351
ttgcaggaaa tgctggcata                                                   20


<210>  352
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  352
atttgcagga aatgctggca                                                   20


<210>  353
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  353
tggcatagag cagcactaaa                                                   20


<210>  354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  354
uuugcaggaa augcuggcau                                                   20


<210>  355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  355
uucucauuug caggaaaugc                                                   20


<210>  356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  356
cauuuagugc ugcucuaugc                                                   20


<210>  357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  357
caggaaaugc uggcauagag                                                   20


<210>  358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  358
uugcaggaaa ugcuggcaua                                                   20


<210>  359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  359
auuugcagga aaugcuggca                                                   20


<210>  360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  360
uggcauagag cagcacuaaa                                                   20


<210>  361
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  361
tggcatagag cagcactaaa                                                   20


<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  362
uggcauagag cagcacuaaa                                                   20


<210>  363
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  363
gtgaaacaaa atgcttttta acatccatat aaagctatct atatatagct atctatatct       60

atatagctat tttttttaac ttcctttatt ttccttacag ggttttagac aaaatcaaaa      120

agaaggaagg tgctcacatt ccttaaatta aggagtaagt ctgccagcat tatgaaagtg      180

aatcttactt ttgtaaaact ttatggtttg tggaaaacaa atgtttttga acatttaaaa      240

agttcagatg t                                                           251


<210>  364
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  364
attttgtcta aaaccctgta                                                   20


<210>  365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  365
auuuugucua aaacccugua                                                   20


<210>  366
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  366
tttgtctaaa accctgtaag                                                   20


<210>  367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  367
uuugucuaaa acccuguaag                                                   20


<210>  368
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  368
ttttgtctaa aaccctgtaa                                                   20


<210>  369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  369
uuuugucuaa aacccuguaa                                                   20


<210>  370
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  370
tgattttgtc taaaaccc                                                     18


<210>  371
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  371
ugauuuuguc uaaaaccc                                                     18


<210>  372
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  372
gattttgtct aaaaccct                                                     18


<210>  373
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  373
gauuuugucu aaaacccu                                                     18


<210>  374
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  374
attttgtcta aaaccctg                                                     18


<210>  375
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  375
auuuugucua aaacccug                                                     18


<210>  376
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  376
gtctaaaacc ctgtaagg                                                     18


<210>  377
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  377
gucuaaaacc cuguaagg                                                     18


<210>  378
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  378
tctaaaaccc tgtaagga                                                     18


<210>  379
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  379
ucuaaaaccc uguaagga                                                     18


<210>  380
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  380
ctctggttct aatttctcat ttgcaggaaa tgctggcata gagcagcact aaatgacacc       60

actaaagaaa cgatca                                                       76


<210>  381
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  381
tttgcaggaa atgctggcat                                                   20


<210>  382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  382
uuugcaggaa augcuggcau                                                   20


<210>  383
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  383
ttctcatttg caggaaatgc                                                   20


<210>  384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  384
uucucauuug caggaaaugc                                                   20


<210>  385
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  385
catttagtgc tgctctatgc                                                   20


<210>  386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  386
cauuuagugc ugcucuaugc                                                   20


<210>  387
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  387
caggaaatgc tggcatagag                                                   20


<210>  388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  388
caggaaaugc uggcauagag                                                   20


<210>  389
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  389
ttgcaggaaa tgctggcata                                                   20


<210>  390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  390
uugcaggaaa ugcuggcaua                                                   20


<210>  391
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  391
atttgcagga aatgctggca                                                   20


<210>  392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  392
auuugcagga aaugcuggca                                                   20


<210>  393
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  393
tggcatagag cagcactaaa                                                   20


<210>  394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  394
uggcauagag cagcacuaaa                                                   20


<210>  395
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  395
ctttgggaag tatgttaatt tcatggtaca tgagtggcta tcatactggc tattatatgg       60

taagtaatca ctcagcatct tttcctgaca atttttttgt agttatgtga ctttgttttg      120

taaattt                                                                127


<210>  396
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  396
tacatgagtg gctatcatac                                                   20


<210>  397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  397
uacaugagug gcuaucauac                                                   20


<210>  398
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  398
ttttccttac agggttttag                                                   20


<210>  399
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  399
atttcatggt acatgagtgg                                                   20


<210>  400
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  400
ugagccgcug                                                              10


<210>  401
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  401
ugagccgcug g                                                            11


<210>  402
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(29)
<223>  may be absent

<220>
<221>  misc_feature
<222>  (32)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  may be absent

<400>  402

His Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Cys Xaa 
            20                  25                  30          


Xaa Xaa Xaa Cys 
        35      


<210>  403
<211>  166
<212>  PRT
<213>  Escherichia coli

<400>  403

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  404
<211>  498
<212>  DNA
<213>  Escherichia coli

<400>  404
tctgaggtgg agttttccca cgagtactgg atgagacatg ccctgaccct ggccaagagg       60

gcacgcgatg agagggaggt gcctgtggga gccgtgctgg tgctgaacaa tagagtgatc      120

ggcgagggct ggaacagagc catcggcctg cacgacccaa cagcccatgc cgaaattatg      180

gccctgagac agggcggcct ggtcatgcag aactacagac tgattgacgc caccctgtac      240

gtgacattcg agccttgcgt gatgtgcgcc ggcgccatga tccactctag gatcggccgc      300

gtggtgtttg gcgtgaggaa cgcaaaaacc ggcgccgcag gctccctgat ggacgtgctg      360

cactaccccg gcatgaatca ccgcgtcgaa attaccgagg gaatcctggc agatgaatgt      420

gccgccctgc tgtgctattt ctttcggatg cctagacagg tgttcaatgc tcagaagaag      480

gcccagagct ccaccgac                                                    498


<210>  405
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  405
auuuugucua aaacccugua guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu       60

ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu                         102


<210>  406
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  406
auuuugucua aaacccugua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uuu                        103


<210>  407
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  407

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Gln Tyr  Arg Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  408
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  408
gtctaaaacc ctgtaaggaa                                                   20


<210>  409
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  409
tgtctaaaac cctgtaagga                                                   20


<210>  410
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  410
ttgtctaaaa ccctgtaagg                                                   20


<210>  411
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  411
attttgtcta aaaccctgta agg                                               23


<210>  412
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  412
gattttgtct aaaaccctgt aag                                               23


<210>  413
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  413
tgattttgtc taaaaccctg taa                                               23


<210>  414
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  414
gaaaccctgt aaggaaaata a                                                 21


<210>  415
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  415
gtttgtctaa aaccctgtaa g                                                 21


<210>  416
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  416
gttttgtcta aaaccctgta a                                                 21


<210>  417
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  417
gtgagcacct tccttctttt                                                   20


<210>  418
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  418
gatgtgagca ccttccttct t                                                 21


<210>  419
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  419
gactccttaa tttaaggaat g                                                 21


<210>  420
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  420
gcagacttac tccttaattt a                                                 21


<210>  421
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  421
gcagacttac tccttaattt a                                                 21


<210>  422
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  422
gtaatgctgg cagacttact c                                                 21


<210>  423
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  423
gttcactttc ataatgctgg c                                                 21


<210>  424
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  424
gaagattcac tttcataatg c                                                 21


<210>  425
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  425
gacaaaagta agattcactt t                                                 21


<210>  426
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  426
gacttccttt attttcctta c                                                 21


<210>  427
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  427
gaacttcctt tattttcctt a                                                 21


<210>  428
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  428
gtttccttac agggttttag a                                                 21


<210>  429
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  429
gtttagacaa aatcaaaaag a                                                 21


<210>  430
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  430
gttagacaaa atcaaaaaga a                                                 21


<210>  431
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  431
gtagacaaaa tcaaaaagaa g                                                 21


<210>  432
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  432
gacaaaatca aaaagaagga                                                   20


<210>  433
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  433
gaaggaaggt gctcacattc c                                                 21


<210>  434
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  434
gtgctcacat tccttaaatt a                                                 21


<210>  435
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  435
gtgctcacat tccttaaatt                                                   20


<210>  436
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  436
gtgctcacat tccttaaatt a                                                 21


<210>  437
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  437
gcacattcct taaattaagg a                                                 21


<210>  438
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  438
gagtaagtct gccagcatta                                                   20


<210>  439
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  439
agtaagtctg ccagcattat                                                   20


<210>  440
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  440
gtctgccagc attatgaaag                                                   20


<210>  441
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  441
gagtctgcca gcattatgaa a                                                 21


<210>  442
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  442
gcttactttt gtaaaacttt a                                                 21


<210>  443
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  443
gttgtaaaac tttatggttt g                                                 21


<210>  444
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  444
aagcctctgg ttctaatttc tcatttgcag gaaatgctgg catagagcag cactaaatga       60

caccactaaa gaaacgatca g                                                 81


<210>  445
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  445
gtttcctgca aatgagaaat t                                                 21


<210>  446
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  446
gccagcattt cctgcaaatg                                                   20


<210>  447
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  447
gatgccagca tttcctgcaa a                                                 21


<210>  448
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  448
gctctatgcc agcatttcct                                                   20


<210>  449
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  449
gaatgctggc atagagcagc a                                                 21


<210>  450
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  450
gtggcataga gcagcactaa a                                                 21


<210>  451
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  451
tcacgaaaaa gccaagatgc                                                   20


<210>  452
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  452
ctgtacaggc cacattgaga                                                   20


<210>  453
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  453
agagatccgg acagaatcgc                                                   20


<210>  454
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  454
cagccacatg gtgtcgcggc                                                   20


<210>  455
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  455
ggttttacag agatcccttc                                                   20


<210>  456
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  456
cagccggtgc agggtgccca                                                   20


<210>  457
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  457
cactgagtgg tacaagaacg                                                   20


<210>  458
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  458
tgcctatcgc cacagcaagc                                                   20


<210>  459
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  459
aacactgagt ggtacaagaa                                                   20


<210>  460
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  460
tggctgctcg gtctccaggg                                                   20


<210>  461
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  461
ttcccagtgg gcacagagga                                                   20


<210>  462
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  462

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ser Lys Arg Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Ile Asn 
                165         


<210>  463
<211>  2135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  463

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Val 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ile  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Gly 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Leu  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Cys Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Ile Lys  Val Met Gly Gly His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Glu Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Ala 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1835                 1840                 1845             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Gly  Asn Ser Asp 
    1850                 1855                 1860             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1865                 1870                 1875             


Gly Phe  Asn Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1880                 1885                 1890             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1895                 1900                 1905             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1910                 1915                 1920             


Pro Ile  Gly Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1925                 1930                 1935             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1940                 1945                 1950             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Ser Val  Leu His Lys 
    1955                 1960                 1965             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1970                 1975                 1980             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Ser  Glu Asp Asn 
    1985                 1990                 1995             


Lys Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2000                 2005                 2010             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2015                 2020                 2025             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2030                 2035                 2040             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2045                 2050                 2055             


Phe Thr  Leu Thr Asn Leu Gly  Ala Ser Ala Ala Phe  Lys Tyr Phe 
    2060                 2065                 2070             


Asp Thr  Thr Ile Gly Arg Lys  Leu Tyr Thr Ser Thr  Lys Glu Val 
    2075                 2080                 2085             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2090                 2095                 2100             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2105                 2110                 2115             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  464
<211>  2127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  464

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Ile Gln Thr 
    1835                 1840                 1845             


Val Gly  Gln Asn Gly Gly Leu  Phe Asp Asp Asn Pro  Lys Ser Pro 
    1850                 1855                 1860             


Leu Glu  Val Thr Pro Ser Lys  Leu Val Pro Leu Lys  Lys Glu Leu 
    1865                 1870                 1875             


Asn Pro  Lys Lys Tyr Gly Gly  Tyr Gln Lys Pro Thr  Thr Ala Tyr 
    1880                 1885                 1890             


Pro Val  Leu Leu Ile Thr Asp  Thr Lys Gln Leu Ile  Pro Ile Ser 
    1895                 1900                 1905             


Val Met  Asn Lys Lys Gln Phe  Glu Gln Asn Pro Val  Lys Phe Leu 
    1910                 1915                 1920             


Arg Asp  Arg Gly Tyr Gln Gln  Val Gly Lys Asn Asp  Phe Ile Lys 
    1925                 1930                 1935             


Leu Pro  Lys Tyr Thr Leu Val  Asp Ile Gly Asp Gly  Ile Lys Arg 
    1940                 1945                 1950             


Leu Trp  Ala Ser Ser Lys Glu  Ile His Lys Gly Asn  Gln Leu Val 
    1955                 1960                 1965             


Val Ser  Lys Lys Ser Gln Ile  Leu Leu Tyr His Ala  His His Leu 
    1970                 1975                 1980             


Asp Ser  Asp Leu Ser Asn Asp  Tyr Leu Gln Asn His  Asn Gln Gln 
    1985                 1990                 1995             


Phe Asp  Val Leu Phe Asn Glu  Ile Ile Ser Phe Ser  Lys Lys Cys 
    2000                 2005                 2010             


Lys Leu  Gly Lys Glu His Ile  Gln Lys Ile Glu Asn  Val Tyr Ser 
    2015                 2020                 2025             


Asn Lys  Lys Asn Ser Ala Ser  Ile Glu Glu Leu Ala  Glu Ser Phe 
    2030                 2035                 2040             


Ile Lys  Leu Leu Gly Phe Thr  Gln Leu Gly Ala Thr  Ser Pro Phe 
    2045                 2050                 2055             


Asn Phe  Leu Gly Val Lys Leu  Asn Gln Lys Gln Tyr  Lys Gly Lys 
    2060                 2065                 2070             


Lys Asp  Tyr Ile Leu Pro Cys  Thr Glu Gly Thr Leu  Ile Arg Gln 
    2075                 2080                 2085             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Val Asp Leu  Ser Lys Ile 
    2090                 2095                 2100             


Gly Glu  Asp Ser Gly Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu 
    2105                 2110                 2115             


Phe Glu  Pro Lys Lys Lys Arg  Lys Val 
    2120                 2125         


<210>  465
<211>  2155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  465

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Ile Met Asn Phe 
            740                 745                 750         


Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro 
        755                 760                 765             


Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly 
    770                 775                 780                 


Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn 
785                 790                 795                 800 


Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser 
                805                 810                 815     


Ile Arg Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp 
            820                 825                 830         


Trp Asp Pro Lys Lys Tyr Gly Gly Phe Val Ser Pro Thr Val Ala Tyr 
        835                 840                 845             


Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu 
    850                 855                 860                 


Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 
865                 870                 875                 880 


Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 
                885                 890                 895     


Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu 
            900                 905                 910         


Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Arg Phe Leu Gln 
        915                 920                 925             


Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr 
    930                 935                 940                 


Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu 
945                 950                 955                 960 


Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile 
                965                 970                 975     


Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala 
            980                 985                 990         


Asn Leu Asp Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
        995                 1000                 1005             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1010                 1015                 1020             


Asn Leu  Gly Ala Pro Arg Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1025                 1030                 1035             


Asp Arg  Lys Val Tyr Arg Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1040                 1045                 1050             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1055                 1060                 1065             


Leu Ser  Gln Leu Gly Gly Asp  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1070                 1075                 1080             


Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser Gly Gly  Asp Lys Lys 
    1085                 1090                 1095             


Tyr Ser  Ile Gly Leu Ala Ile  Gly Thr Asn Ser Val  Gly Trp Ala 
    1100                 1105                 1110             


Val Ile  Thr Asp Glu Tyr Lys  Val Pro Ser Lys Lys  Phe Lys Val 
    1115                 1120                 1125             


Leu Gly  Asn Thr Asp Arg His  Ser Ile Lys Lys Asn  Leu Ile Gly 
    1130                 1135                 1140             


Ala Leu  Leu Phe Asp Ser Gly  Glu Thr Ala Glu Ala  Thr Arg Leu 
    1145                 1150                 1155             


Lys Arg  Thr Ala Arg Arg Arg  Tyr Thr Arg Arg Lys  Asn Arg Ile 
    1160                 1165                 1170             


Cys Tyr  Leu Gln Glu Ile Phe  Ser Asn Glu Met Ala  Lys Val Asp 
    1175                 1180                 1185             


Asp Ser  Phe Phe His Arg Leu  Glu Glu Ser Phe Leu  Val Glu Glu 
    1190                 1195                 1200             


Asp Lys  Lys His Glu Arg His  Pro Ile Phe Gly Asn  Ile Val Asp 
    1205                 1210                 1215             


Glu Val  Ala Tyr His Glu Lys  Tyr Pro Thr Ile Tyr  His Leu Arg 
    1220                 1225                 1230             


Lys Lys  Leu Val Asp Ser Thr  Asp Lys Ala Asp Leu  Arg Leu Ile 
    1235                 1240                 1245             


Tyr Leu  Ala Leu Ala His Met  Ile Lys Phe Arg Gly  His Phe Leu 
    1250                 1255                 1260             


Ile Glu  Gly Asp Leu Asn Pro  Asp Asn Ser Asp Val  Asp Lys Leu 
    1265                 1270                 1275             


Phe Ile  Gln Leu Val Gln Thr  Tyr Asn Gln Leu Phe  Glu Glu Asn 
    1280                 1285                 1290             


Pro Ile  Asn Ala Ser Gly Val  Asp Ala Lys Ala Ile  Leu Ser Ala 
    1295                 1300                 1305             


Arg Leu  Ser Lys Ser Arg Arg  Leu Glu Asn Leu Ile  Ala Gln Leu 
    1310                 1315                 1320             


Pro Gly  Glu Lys Lys Asn Gly  Leu Phe Gly Asn Leu  Ile Ala Leu 
    1325                 1330                 1335             


Ser Leu  Gly Leu Thr Pro Asn  Phe Lys Ser Asn Phe  Asp Leu Ala 
    1340                 1345                 1350             


Glu Asp  Ala Lys Leu Gln Leu  Ser Lys Asp Thr Tyr  Asp Asp Asp 
    1355                 1360                 1365             


Leu Asp  Asn Leu Leu Ala Gln  Ile Gly Asp Gln Tyr  Ala Asp Leu 
    1370                 1375                 1380             


Phe Leu  Ala Ala Lys Asn Leu  Ser Asp Ala Ile Leu  Leu Ser Asp 
    1385                 1390                 1395             


Ile Leu  Arg Val Asn Thr Glu  Ile Thr Lys Ala Pro  Leu Ser Ala 
    1400                 1405                 1410             


Ser Met  Ile Lys Arg Tyr Asp  Glu His His Gln Asp  Leu Thr Leu 
    1415                 1420                 1425             


Leu Lys  Ala Leu Val Arg Gln  Gln Leu Pro Glu Lys  Tyr Lys Glu 
    1430                 1435                 1440             


Ile Phe  Phe Asp Gln Ser Lys  Asn Gly Tyr Ala Gly  Tyr Ile Asp 
    1445                 1450                 1455             


Gly Gly  Ala Ser Gln Glu Glu  Phe Tyr Lys Phe Ile  Lys Pro Ile 
    1460                 1465                 1470             


Leu Glu  Lys Met Asp Gly Thr  Glu Glu Leu Leu Val  Lys Leu Asn 
    1475                 1480                 1485             


Arg Glu  Asp Leu Leu Arg Lys  Gln Arg Thr Phe Asp  Asn Gly Ser 
    1490                 1495                 1500             


Ile Pro  His Gln Ile His Leu  Gly Glu Leu His Ala  Ile Leu Arg 
    1505                 1510                 1515             


Arg Gln  Glu Asp Phe Tyr Pro  Phe Leu Lys Asp Asn  Arg Glu Lys 
    1520                 1525                 1530             


Ile Glu  Lys Ile Leu Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro 
    1535                 1540                 1545             


Leu Ala  Arg Gly Asn Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser 
    1550                 1555                 1560             


Glu Glu  Thr Ile Thr Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys 
    1565                 1570                 1575             


Gly Ala  Ser Ala Gln Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp 
    1580                 1585                 1590             


Lys Asn  Leu Pro Asn Glu Lys  Val Leu Pro Lys His  Ser Leu Leu 
    1595                 1600                 1605             


Tyr Glu  Tyr Phe Thr Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr 
    1610                 1615                 1620             


Val Thr  Glu Gly Met Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln 
    1625                 1630                 1635             


Lys Lys  Ala Ile Val Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val 
    1640                 1645                 1650             


Thr Val  Lys Gln Leu Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys 
    1655                 1660                 1665             


Phe Asp  Ser Val Glu Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala 
    1670                 1675                 1680             


Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys 
    1685                 1690                 1695             


Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile 
    1700                 1705                 1710             


Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu 
    1715                 1720                 1725             


Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp Asp Lys  Val Met Lys 
    1730                 1735                 1740             


Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg 
    1745                 1750                 1755             


Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile 
    1760                 1765                 1770             


Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met 
    1775                 1780                 1785             


Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln 
    1790                 1795                 1800             


Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser Leu His  Glu His Ile 
    1805                 1810                 1815             


Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln 
    1820                 1825                 1830             


Thr Val  Lys Val Val Asp Glu  Leu Val Lys Val Met  Gly Arg His 
    1835                 1840                 1845             


Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr 
    1850                 1855                 1860             


Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile 
    1865                 1870                 1875             


Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His 
    1880                 1885                 1890             


Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr 
    1895                 1900                 1905             


Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp 
    1910                 1915                 1920             


Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp His Ile  Val Pro Gln 
    1925                 1930                 1935             


Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg 
    1940                 1945                 1950             


Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu 
    1955                 1960                 1965             


Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala 
    1970                 1975                 1980             


Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu 
    1985                 1990                 1995             


Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg 
    2000                 2005                 2010             


Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys His Val  Ala Gln Ile 
    2015                 2020                 2025             


Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu 
    2030                 2035                 2040             


Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser 
    2045                 2050                 2055             


Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn 
    2060                 2065                 2070             


Asn Tyr  His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Val Gly 
    2075                 2080                 2085             


Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
    2090                 2095                 2100             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    2105                 2110                 2115             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    2120                 2125                 2130             


Ser Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    2135                 2140                 2145             


Pro Lys  Lys Lys Arg Lys Val  
    2150                 2155 


<210>  466
<211>  1821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  466

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr 
            740                 745                 750         


Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile 
        755                 760                 765             


Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys 
    770                 775                 780                 


Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala 
785                 790                 795                 800 


Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys 
                805                 810                 815     


Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly 
            820                 825                 830         


Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser 
        835                 840                 845             


Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly 
    850                 855                 860                 


Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser 
865                 870                 875                 880 


Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr 
                885                 890                 895     


Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg 
            900                 905                 910         


Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys 
        915                 920                 925             


Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe 
    930                 935                 940                 


Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu 
945                 950                 955                 960 


Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp 
                965                 970                 975     


Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg 
            980                 985                 990         


Ser Val Lys Tyr Ala Tyr Asn Ala  Asp Leu Tyr Asn Ala  Leu Asn Asp 
        995                 1000                 1005             


Leu Asn  Asn Leu Val Ile Thr  Arg Asp Glu Asn Glu  Lys Leu Glu 
    1010                 1015                 1020             


Tyr Tyr  Glu Lys Phe Gln Ile  Ile Glu Asn Val Phe  Lys Gln Lys 
    1025                 1030                 1035             


Lys Lys  Pro Thr Leu Lys Gln  Ile Ala Lys Glu Ile  Leu Val Asn 
    1040                 1045                 1050             


Glu Glu  Asp Ile Lys Gly Tyr  Arg Val Thr Ser Thr  Gly Lys Pro 
    1055                 1060                 1065             


Glu Phe  Thr Asn Leu Lys Val  Tyr His Asp Ile Lys  Asp Ile Thr 
    1070                 1075                 1080             


Ala Arg  Lys Glu Ile Ile Glu  Asn Ala Glu Leu Leu  Asp Gln Ile 
    1085                 1090                 1095             


Ala Lys  Ile Leu Thr Ile Tyr  Gln Ser Ser Glu Asp  Ile Gln Glu 
    1100                 1105                 1110             


Glu Leu  Thr Asn Leu Asn Ser  Glu Leu Thr Gln Glu  Glu Ile Glu 
    1115                 1120                 1125             


Gln Ile  Ser Asn Leu Lys Gly  Tyr Thr Gly Thr His  Asn Leu Ser 
    1130                 1135                 1140             


Leu Lys  Ala Ile Asn Leu Ile  Leu Asp Glu Leu Trp  His Thr Asn 
    1145                 1150                 1155             


Asp Asn  Gln Ile Ala Ile Phe  Asn Arg Leu Lys Leu  Val Pro Lys 
    1160                 1165                 1170             


Lys Val  Asp Leu Ser Gln Gln  Lys Glu Ile Pro Thr  Thr Leu Val 
    1175                 1180                 1185             


Asp Asp  Phe Ile Leu Ser Pro  Val Val Lys Arg Ser  Phe Ile Gln 
    1190                 1195                 1200             


Ser Ile  Lys Val Ile Asn Ala  Ile Ile Lys Lys Tyr  Gly Leu Pro 
    1205                 1210                 1215             


Asn Asp  Ile Ile Ile Glu Leu  Ala Arg Glu Lys Asn  Ser Lys Asp 
    1220                 1225                 1230             


Ala Gln  Lys Met Ile Asn Glu  Met Gln Lys Arg Asn  Arg Gln Thr 
    1235                 1240                 1245             


Asn Glu  Arg Ile Glu Glu Ile  Ile Arg Thr Thr Gly  Lys Glu Asn 
    1250                 1255                 1260             


Ala Lys  Tyr Leu Ile Glu Lys  Ile Lys Leu His Asp  Met Gln Glu 
    1265                 1270                 1275             


Gly Lys  Cys Leu Tyr Ser Leu  Glu Ala Ile Pro Leu  Glu Asp Leu 
    1280                 1285                 1290             


Leu Asn  Asn Pro Phe Asn Tyr  Glu Val Asp His Ile  Ile Pro Arg 
    1295                 1300                 1305             


Ser Val  Ser Phe Asp Asn Ser  Phe Asn Asn Lys Val  Leu Val Lys 
    1310                 1315                 1320             


Gln Glu  Glu Asn Ser Lys Lys  Gly Asn Arg Thr Pro  Phe Gln Tyr 
    1325                 1330                 1335             


Leu Ser  Ser Ser Asp Ser Lys  Ile Ser Tyr Glu Thr  Phe Lys Lys 
    1340                 1345                 1350             


His Ile  Leu Asn Leu Ala Lys  Gly Lys Gly Arg Ile  Ser Lys Thr 
    1355                 1360                 1365             


Lys Lys  Glu Tyr Leu Leu Glu  Glu Arg Asp Ile Asn  Arg Phe Ser 
    1370                 1375                 1380             


Val Gln  Lys Asp Phe Ile Asn  Arg Asn Leu Val Asp  Thr Arg Tyr 
    1385                 1390                 1395             


Ala Thr  Arg Gly Leu Met Asn  Leu Leu Arg Ser Tyr  Phe Arg Val 
    1400                 1405                 1410             


Asn Asn  Leu Asp Val Lys Val  Lys Ser Ile Asn Gly  Gly Phe Thr 
    1415                 1420                 1425             


Ser Phe  Leu Arg Arg Lys Trp  Lys Phe Lys Lys Glu  Arg Asn Lys 
    1430                 1435                 1440             


Gly Tyr  Lys His His Ala Glu  Asp Ala Leu Ile Ile  Ala Asn Ala 
    1445                 1450                 1455             


Asp Phe  Ile Phe Lys Glu Trp  Lys Lys Leu Asp Lys  Ala Lys Lys 
    1460                 1465                 1470             


Val Met  Glu Asn Gln Met Phe  Glu Glu Lys Gln Ala  Glu Ser Met 
    1475                 1480                 1485             


Pro Glu  Ile Glu Thr Glu Gln  Glu Tyr Lys Glu Ile  Phe Ile Thr 
    1490                 1495                 1500             


Pro His  Gln Ile Lys His Ile  Lys Asp Phe Lys Asp  Tyr Lys Tyr 
    1505                 1510                 1515             


Ser His  Arg Val Asp Lys Lys  Pro Asn Arg Glu Leu  Ile Asn Asp 
    1520                 1525                 1530             


Thr Leu  Tyr Ser Thr Arg Lys  Asp Asp Lys Gly Asn  Thr Leu Ile 
    1535                 1540                 1545             


Val Asn  Asn Leu Asn Gly Leu  Tyr Asp Lys Asp Asn  Asp Lys Leu 
    1550                 1555                 1560             


Lys Lys  Leu Ile Asn Lys Ser  Pro Glu Lys Leu Leu  Met Tyr His 
    1565                 1570                 1575             


His Asp  Pro Gln Thr Tyr Gln  Lys Leu Lys Leu Ile  Met Glu Gln 
    1580                 1585                 1590             


Tyr Gly  Asp Glu Lys Asn Pro  Leu Tyr Lys Tyr Tyr  Glu Glu Thr 
    1595                 1600                 1605             


Gly Asn  Tyr Leu Thr Lys Tyr  Ser Lys Lys Asp Asn  Gly Pro Val 
    1610                 1615                 1620             


Ile Lys  Lys Ile Lys Tyr Tyr  Gly Asn Lys Leu Asn  Ala His Leu 
    1625                 1630                 1635             


Asp Ile  Thr Asp Asp Tyr Pro  Asn Ser Arg Asn Lys  Val Val Lys 
    1640                 1645                 1650             


Leu Ser  Leu Lys Pro Tyr Arg  Phe Asp Val Tyr Leu  Asp Asn Gly 
    1655                 1660                 1665             


Val Tyr  Lys Phe Val Thr Val  Lys Asn Leu Asp Val  Ile Lys Lys 
    1670                 1675                 1680             


Glu Asn  Tyr Tyr Glu Val Asn  Ser Lys Cys Tyr Glu  Glu Ala Lys 
    1685                 1690                 1695             


Lys Leu  Lys Lys Ile Ser Asn  Gln Ala Glu Phe Ile  Ala Ser Phe 
    1700                 1705                 1710             


Tyr Asn  Asn Asp Leu Ile Lys  Ile Asn Gly Glu Leu  Tyr Arg Val 
    1715                 1720                 1725             


Ile Gly  Val Asn Asn Asp Leu  Leu Asn Arg Ile Glu  Val Asn Met 
    1730                 1735                 1740             


Ile Asp  Ile Thr Tyr Arg Glu  Tyr Leu Glu Asn Met  Asn Asp Lys 
    1745                 1750                 1755             


Arg Pro  Pro Arg Ile Ile Lys  Thr Ile Ala Ser Lys  Thr Gln Ser 
    1760                 1765                 1770             


Ile Lys  Lys Tyr Ser Thr Asp  Ile Leu Gly Asn Leu  Tyr Glu Val 
    1775                 1780                 1785             


Lys Ser  Lys Lys His Pro Gln  Ile Ile Lys Lys Gly  Ser Gly Gly 
    1790                 1795                 1800             


Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys 
    1805                 1810                 1815             


Arg Lys  Val 
    1820     


<210>  467
<211>  2135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  467

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Val 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ile  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Gly 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Leu  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Cys Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Ile Lys  Val Met Gly Gly His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Glu Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Ala 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1835                 1840                 1845             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Gly  Asn Ser Asp 
    1850                 1855                 1860             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1865                 1870                 1875             


Gly Phe  Asn Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1880                 1885                 1890             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1895                 1900                 1905             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1910                 1915                 1920             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1925                 1930                 1935             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1940                 1945                 1950             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Val  Leu Gln Lys 
    1955                 1960                 1965             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1970                 1975                 1980             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1985                 1990                 1995             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2000                 2005                 2010             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2015                 2020                 2025             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2030                 2035                 2040             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2045                 2050                 2055             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    2060                 2065                 2070             


Asp Thr  Thr Ile Asn Arg Lys  Gln Tyr Asn Thr Thr  Lys Glu Val 
    2075                 2080                 2085             


Leu Asp  Ala Thr Leu Ile Arg  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2090                 2095                 2100             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2105                 2110                 2115             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  468
<211>  2135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  468

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Val 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ile  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Gly 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Leu  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Cys Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Ile Lys  Val Met Gly Gly His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Glu Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Ala 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1835                 1840                 1845             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Gly  Asn Ser Asp 
    1850                 1855                 1860             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1865                 1870                 1875             


Gly Phe  Asn Ser Pro Thr Ala  Ala Tyr Ser Val Leu  Val Val Ala 
    1880                 1885                 1890             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1895                 1900                 1905             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1910                 1915                 1920             


Pro Ile  Gly Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1925                 1930                 1935             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1940                 1945                 1950             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Val  Leu His Lys 
    1955                 1960                 1965             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1970                 1975                 1980             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1985                 1990                 1995             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2000                 2005                 2010             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2015                 2020                 2025             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2030                 2035                 2040             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2045                 2050                 2055             


Phe Thr  Leu Thr Asn Leu Gly  Val Pro Ala Ala Phe  Lys Tyr Phe 
    2060                 2065                 2070             


Asp Thr  Thr Ile Asp Lys Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    2075                 2080                 2085             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2090                 2095                 2100             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2105                 2110                 2115             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  469
<211>  3927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  469

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Gly Gly Ala Ala 
            740                 745                 750         


Gly Cys Gly Ala Ala Ala Thr Thr Ala Cys Ala Thr Thr Cys Thr Gly 
        755                 760                 765             


Gly Gly Gly Cys Thr Gly Gly Cys Cys Ala Thr Thr Gly Gly Cys Ala 
    770                 775                 780                 


Thr Thr Ala Cys Ala Thr Cys Ala Gly Thr Gly Gly Gly Cys Thr Ala 
785                 790                 795                 800 


Thr Gly Gly Cys Ala Thr Cys Ala Thr Thr Gly Ala Cys Thr Ala Cys 
                805                 810                 815     


Gly Ala Gly Ala Cys Ala Ala Gly Gly Gly Ala Cys Gly Thr Gly Ala 
            820                 825                 830         


Thr Cys Gly Ala Cys Gly Cys Cys Gly Gly Cys Gly Thr Gly Ala Gly 
        835                 840                 845             


Ala Cys Thr Gly Thr Thr Cys Ala Ala Gly Gly Ala Gly Gly Cys Cys 
    850                 855                 860                 


Ala Ala Cys Gly Thr Gly Gly Ala Gly Ala Ala Cys Ala Ala Thr Gly 
865                 870                 875                 880 


Ala Gly Gly Gly Cys Cys Gly Gly Ala Gly Ala Thr Cys Cys Ala Ala 
                885                 890                 895     


Gly Ala Gly Gly Gly Gly Ala Gly Cys Ala Ala Gly Gly Cys Gly Cys 
            900                 905                 910         


Cys Thr Gly Ala Ala Gly Cys Gly Gly Ala Gly Ala Ala Gly Gly Cys 
        915                 920                 925             


Gly Cys Cys Ala Cys Ala Gly Ala Ala Thr Cys Cys Ala Gly Ala Gly 
    930                 935                 940                 


Ala Gly Thr Gly Ala Ala Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly 
945                 950                 955                 960 


Thr Thr Cys Gly Ala Thr Thr Ala Cys Ala Ala Cys Cys Thr Gly Cys 
                965                 970                 975     


Thr Gly Ala Cys Cys Gly Ala Cys Cys Ala Cys Thr Cys Cys Gly Ala 
            980                 985                 990         


Gly Cys Thr Gly Thr Cys Thr Gly  Gly Cys Ala Thr Cys  Ala Ala Thr 
        995                 1000                 1005             


Cys Cys  Thr Thr Ala Thr Gly  Ala Gly Gly Cys Cys  Ala Gly Ala 
    1010                 1015                 1020             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Cys Thr Gly  Thr Cys Cys 
    1025                 1030                 1035             


Cys Ala  Gly Ala Ala Gly Cys  Thr Gly Thr Cys Thr  Gly Ala Gly 
    1040                 1045                 1050             


Gly Ala  Gly Gly Ala Gly Thr  Thr Thr Ala Gly Cys  Gly Cys Cys 
    1055                 1060                 1065             


Gly Cys  Cys Cys Thr Gly Cys  Thr Gly Cys Ala Cys  Cys Thr Gly 
    1070                 1075                 1080             


Gly Cys  Ala Ala Ala Gly Ala  Gly Gly Ala Gly Ala  Gly Gly Cys 
    1085                 1090                 1095             


Gly Thr  Gly Cys Ala Cys Ala  Ala Cys Gly Thr Gly  Ala Ala Thr 
    1100                 1105                 1110             


Gly Ala  Gly Gly Thr Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Cys 
    1115                 1120                 1125             


Ala Cys  Cys Gly Gly Cys Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1130                 1135                 1140             


Thr Cys  Cys Ala Cys Ala Ala  Ala Gly Gly Ala Gly  Cys Ala Gly 
    1145                 1150                 1155             


Ala Thr  Cys Ala Gly Cys Cys  Gly Cys Ala Ala Thr  Thr Cys Cys 
    1160                 1165                 1170             


Ala Ala  Gly Gly Cys Cys Cys  Thr Gly Gly Ala Gly  Gly Ala Gly 
    1175                 1180                 1185             


Ala Ala  Gly Thr Ala Thr Gly  Thr Gly Gly Cys Cys  Gly Ala Gly 
    1190                 1195                 1200             


Cys Thr  Gly Cys Ala Gly Cys  Thr Gly Gly Ala Gly  Cys Gly Gly 
    1205                 1210                 1215             


Cys Thr  Gly Ala Ala Gly Ala  Ala Gly Gly Ala Thr  Gly Gly Cys 
    1220                 1225                 1230             


Gly Ala  Gly Gly Thr Gly Ala  Gly Gly Gly Gly Cys  Thr Cys Cys 
    1235                 1240                 1245             


Ala Thr  Cys Ala Ala Thr Cys  Gly Cys Thr Thr Cys  Ala Ala Gly 
    1250                 1255                 1260             


Ala Cys  Cys Thr Cys Thr Gly  Ala Cys Thr Ala Cys  Gly Thr Gly 
    1265                 1270                 1275             


Ala Ala  Gly Gly Ala Gly Gly  Cys Cys Ala Ala Gly  Cys Ala Gly 
    1280                 1285                 1290             


Cys Thr  Gly Cys Thr Gly Ala  Ala Gly Gly Thr Gly  Cys Ala Gly 
    1295                 1300                 1305             


Ala Ala  Gly Gly Cys Cys Thr  Ala Cys Cys Ala Cys  Cys Ala Gly 
    1310                 1315                 1320             


Cys Thr  Gly Gly Ala Thr Cys  Ala Gly Thr Cys Cys  Thr Thr Thr 
    1325                 1330                 1335             


Ala Thr  Cys Gly Ala Thr Ala  Cys Ala Thr Ala Thr  Ala Thr Cys 
    1340                 1345                 1350             


Gly Ala  Cys Cys Thr Gly Cys  Thr Gly Gly Ala Gly  Ala Cys Ala 
    1355                 1360                 1365             


Ala Gly  Gly Cys Gly Cys Ala  Cys Ala Thr Ala Cys  Thr Ala Thr 
    1370                 1375                 1380             


Gly Ala  Gly Gly Gly Ala Cys  Cys Ala Gly Gly Ala  Gly Ala Gly 
    1385                 1390                 1395             


Gly Gly  Cys Thr Cys Thr Cys  Cys Cys Thr Thr Cys  Gly Gly Cys 
    1400                 1405                 1410             


Thr Gly  Gly Ala Ala Gly Gly  Ala Cys Ala Thr Cys  Ala Ala Gly 
    1415                 1420                 1425             


Gly Ala  Gly Thr Gly Gly Thr  Ala Cys Gly Ala Gly  Ala Thr Gly 
    1430                 1435                 1440             


Cys Thr  Gly Ala Thr Gly Gly  Gly Cys Cys Ala Cys  Thr Gly Cys 
    1445                 1450                 1455             


Ala Cys  Cys Thr Ala Thr Thr  Thr Thr Cys Cys Ala  Gly Ala Gly 
    1460                 1465                 1470             


Gly Ala  Gly Cys Thr Gly Ala  Gly Ala Ala Gly Cys  Gly Thr Gly 
    1475                 1480                 1485             


Ala Ala  Gly Thr Ala Cys Gly  Cys Cys Thr Ala Thr  Ala Ala Cys 
    1490                 1495                 1500             


Gly Cys  Cys Gly Ala Thr Cys  Thr Gly Thr Ala Cys  Ala Ala Cys 
    1505                 1510                 1515             


Gly Cys  Cys Cys Thr Gly Ala  Ala Thr Gly Ala Cys  Cys Thr Gly 
    1520                 1525                 1530             


Ala Ala  Cys Ala Ala Cys Cys  Thr Gly Gly Thr Cys  Ala Thr Cys 
    1535                 1540                 1545             


Ala Cys  Cys Ala Gly Gly Gly  Ala Thr Gly Ala Gly  Ala Ala Cys 
    1550                 1555                 1560             


Gly Ala  Gly Ala Ala Gly Cys  Thr Gly Gly Ala Gly  Thr Ala Cys 
    1565                 1570                 1575             


Thr Ala  Thr Gly Ala Gly Ala  Ala Gly Thr Thr Cys  Cys Ala Gly 
    1580                 1585                 1590             


Ala Thr  Cys Ala Thr Cys Gly  Ala Gly Ala Ala Cys  Gly Thr Gly 
    1595                 1600                 1605             


Thr Thr  Cys Ala Ala Gly Cys  Ala Gly Ala Ala Gly  Ala Ala Gly 
    1610                 1615                 1620             


Ala Ala  Gly Cys Cys Thr Ala  Cys Ala Cys Thr Gly  Ala Ala Gly 
    1625                 1630                 1635             


Cys Ala  Gly Ala Thr Cys Gly  Cys Cys Ala Ala Gly  Gly Ala Gly 
    1640                 1645                 1650             


Ala Thr  Cys Cys Thr Gly Gly  Thr Gly Ala Ala Cys  Gly Ala Gly 
    1655                 1660                 1665             


Gly Ala  Gly Gly Ala Cys Ala  Thr Cys Ala Ala Gly  Gly Gly Cys 
    1670                 1675                 1680             


Thr Ala  Cys Cys Gly Cys Gly  Thr Gly Ala Cys Cys  Thr Cys Cys 
    1685                 1690                 1695             


Ala Cys  Ala Gly Gly Cys Ala  Ala Gly Cys Cys Ala  Gly Ala Gly 
    1700                 1705                 1710             


Thr Thr  Cys Ala Cys Cys Ala  Ala Thr Cys Thr Gly  Ala Ala Gly 
    1715                 1720                 1725             


Gly Thr  Gly Thr Ala Thr Cys  Ala Cys Gly Ala Thr  Ala Thr Cys 
    1730                 1735                 1740             


Ala Ala  Gly Gly Ala Cys Ala  Thr Cys Ala Cys Ala  Gly Cys Cys 
    1745                 1750                 1755             


Cys Gly  Gly Ala Ala Gly Gly  Ala Gly Ala Thr Cys  Ala Thr Cys 
    1760                 1765                 1770             


Gly Ala  Gly Ala Ala Cys Gly  Cys Cys Gly Ala Gly  Cys Thr Gly 
    1775                 1780                 1785             


Cys Thr  Gly Gly Ala Thr Cys  Ala Gly Ala Thr Cys  Gly Cys Cys 
    1790                 1795                 1800             


Ala Ala  Gly Ala Thr Cys Cys  Thr Gly Ala Cys Cys  Ala Thr Cys 
    1805                 1810                 1815             


Thr Ala  Thr Cys Ala Gly Ala  Gly Cys Thr Cys Cys  Gly Ala Gly 
    1820                 1825                 1830             


Gly Ala  Cys Ala Thr Cys Cys  Ala Gly Gly Ala Gly  Gly Ala Gly 
    1835                 1840                 1845             


Cys Thr  Gly Ala Cys Cys Ala  Ala Cys Cys Thr Gly  Ala Ala Thr 
    1850                 1855                 1860             


Ala Gly  Cys Gly Ala Gly Cys  Thr Gly Ala Cys Ala  Cys Ala Gly 
    1865                 1870                 1875             


Gly Ala  Gly Gly Ala Gly Ala  Thr Cys Gly Ala Gly  Cys Ala Gly 
    1880                 1885                 1890             


Ala Thr  Cys Ala Gly Cys Ala  Ala Thr Cys Thr Gly  Ala Ala Gly 
    1895                 1900                 1905             


Gly Gly  Cys Thr Ala Cys Ala  Cys Cys Gly Gly Cys  Ala Cys Ala 
    1910                 1915                 1920             


Cys Ala  Cys Ala Ala Cys Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1925                 1930                 1935             


Ala Ala  Gly Gly Cys Cys Ala  Thr Cys Ala Ala Thr  Cys Thr Gly 
    1940                 1945                 1950             


Ala Thr  Cys Cys Thr Gly Gly  Ala Thr Gly Ala Gly  Cys Thr Gly 
    1955                 1960                 1965             


Thr Gly  Gly Cys Ala Cys Ala  Cys Ala Ala Ala Cys  Gly Ala Cys 
    1970                 1975                 1980             


Ala Ala  Thr Cys Ala Gly Ala  Thr Cys Gly Cys Cys  Ala Thr Cys 
    1985                 1990                 1995             


Thr Thr  Thr Ala Ala Cys Cys  Gly Gly Cys Thr Gly  Ala Ala Gly 
    2000                 2005                 2010             


Cys Thr  Gly Gly Thr Gly Cys  Cys Ala Ala Ala Gly  Ala Ala Gly 
    2015                 2020                 2025             


Gly Thr  Gly Gly Ala Cys Cys  Thr Gly Thr Cys Cys  Cys Ala Gly 
    2030                 2035                 2040             


Cys Ala  Gly Ala Ala Gly Gly  Ala Gly Ala Thr Cys  Cys Cys Ala 
    2045                 2050                 2055             


Ala Cys  Cys Ala Cys Ala Cys  Thr Gly Gly Thr Gly  Gly Ala Cys 
    2060                 2065                 2070             


Gly Ala  Thr Thr Thr Cys Ala  Thr Cys Cys Thr Gly  Thr Cys Thr 
    2075                 2080                 2085             


Cys Cys  Cys Gly Thr Gly Gly  Thr Gly Ala Ala Gly  Cys Gly Gly 
    2090                 2095                 2100             


Ala Gly  Cys Thr Thr Cys Ala  Thr Cys Cys Ala Gly  Ala Gly Cys 
    2105                 2110                 2115             


Ala Thr  Cys Ala Ala Ala Gly  Thr Gly Ala Thr Cys  Ala Ala Cys 
    2120                 2125                 2130             


Gly Cys  Cys Ala Thr Cys Ala  Thr Cys Ala Ala Gly  Ala Ala Gly 
    2135                 2140                 2145             


Thr Ala  Cys Gly Gly Cys Cys  Thr Gly Cys Cys Cys  Ala Ala Thr 
    2150                 2155                 2160             


Gly Ala  Thr Ala Thr Cys Ala  Thr Cys Ala Thr Cys  Gly Ala Gly 
    2165                 2170                 2175             


Cys Thr  Gly Gly Cys Cys Ala  Gly Gly Gly Ala Gly  Ala Ala Gly 
    2180                 2185                 2190             


Ala Ala  Cys Thr Cys Cys Ala  Ala Gly Gly Ala Cys  Gly Cys Cys 
    2195                 2200                 2205             


Cys Ala  Gly Ala Ala Gly Ala  Thr Gly Ala Thr Cys  Ala Ala Thr 
    2210                 2215                 2220             


Gly Ala  Gly Ala Thr Gly Cys  Ala Gly Ala Ala Gly  Ala Gly Gly 
    2225                 2230                 2235             


Ala Ala  Cys Cys Gly Cys Cys  Ala Gly Ala Cys Cys  Ala Ala Thr 
    2240                 2245                 2250             


Gly Ala  Gly Cys Gly Gly Ala  Thr Cys Gly Ala Gly  Gly Ala Gly 
    2255                 2260                 2265             


Ala Thr  Cys Ala Thr Cys Ala  Gly Ala Ala Cys Cys  Ala Cys Ala 
    2270                 2275                 2280             


Gly Gly  Cys Ala Ala Gly Gly  Ala Gly Ala Ala Cys  Gly Cys Cys 
    2285                 2290                 2295             


Ala Ala  Gly Thr Ala Cys Cys  Thr Gly Ala Thr Cys  Gly Ala Gly 
    2300                 2305                 2310             


Ala Ala  Gly Ala Thr Cys Ala  Ala Gly Cys Thr Gly  Cys Ala Cys 
    2315                 2320                 2325             


Gly Ala  Thr Ala Thr Gly Cys  Ala Gly Gly Ala Gly  Gly Gly Cys 
    2330                 2335                 2340             


Ala Ala  Gly Thr Gly Thr Cys  Thr Gly Thr Ala Thr  Thr Cys Thr 
    2345                 2350                 2355             


Cys Thr  Gly Gly Ala Gly Gly  Cys Cys Ala Thr Cys  Cys Cys Thr 
    2360                 2365                 2370             


Cys Thr  Gly Gly Ala Gly Gly  Ala Cys Cys Thr Gly  Cys Thr Gly 
    2375                 2380                 2385             


Ala Ala  Cys Ala Ala Thr Cys  Cys Ala Thr Thr Cys  Ala Ala Cys 
    2390                 2395                 2400             


Thr Ala  Cys Gly Ala Gly Gly  Thr Gly Gly Ala Thr  Cys Ala Cys 
    2405                 2410                 2415             


Ala Thr  Cys Ala Thr Cys Cys  Cys Cys Cys Gly Gly  Ala Gly Cys 
    2420                 2425                 2430             


Gly Thr  Gly Ala Gly Cys Thr  Thr Cys Gly Ala Cys  Ala Ala Thr 
    2435                 2440                 2445             


Thr Cys  Thr Thr Thr Thr Ala  Ala Cys Ala Ala Thr  Ala Ala Gly 
    2450                 2455                 2460             


Gly Thr  Gly Cys Thr Gly Gly  Thr Gly Ala Ala Gly  Cys Ala Gly 
    2465                 2470                 2475             


Gly Ala  Gly Gly Ala Gly Ala  Ala Cys Ala Gly Cys  Ala Ala Gly 
    2480                 2485                 2490             


Ala Ala  Gly Gly Gly Cys Ala  Ala Thr Ala Gly Gly  Ala Cys Cys 
    2495                 2500                 2505             


Cys Cys  Thr Thr Thr Cys Cys  Ala Gly Thr Ala Cys  Cys Thr Gly 
    2510                 2515                 2520             


Thr Cys  Thr Ala Gly Cys Thr  Cys Cys Gly Ala Thr  Thr Cys Thr 
    2525                 2530                 2535             


Ala Ala  Gly Ala Thr Cys Ala  Gly Cys Thr Ala Cys  Gly Ala Gly 
    2540                 2545                 2550             


Ala Cys  Ala Thr Thr Cys Ala  Ala Gly Ala Ala Gly  Cys Ala Cys 
    2555                 2560                 2565             


Ala Thr  Cys Cys Thr Gly Ala  Ala Thr Cys Thr Gly  Gly Cys Cys 
    2570                 2575                 2580             


Ala Ala  Gly Gly Gly Cys Ala  Ala Gly Gly Gly Cys  Cys Gly Cys 
    2585                 2590                 2595             


Ala Thr  Cys Ala Gly Cys Ala  Ala Gly Ala Cys Cys  Ala Ala Gly 
    2600                 2605                 2610             


Ala Ala  Gly Gly Ala Gly Thr  Ala Cys Cys Thr Gly  Cys Thr Gly 
    2615                 2620                 2625             


Gly Ala  Gly Gly Ala Gly Cys  Gly Gly Gly Ala Cys  Ala Thr Cys 
    2630                 2635                 2640             


Ala Ala  Cys Ala Gly Ala Thr  Thr Cys Thr Cys Cys  Gly Thr Gly 
    2645                 2650                 2655             


Cys Ala  Gly Ala Ala Gly Gly  Ala Cys Thr Thr Cys  Ala Thr Cys 
    2660                 2665                 2670             


Ala Ala  Cys Cys Gly Gly Ala  Ala Thr Cys Thr Gly  Gly Thr Gly 
    2675                 2680                 2685             


Gly Ala  Cys Ala Cys Cys Ala  Gly Ala Thr Ala Cys  Gly Cys Cys 
    2690                 2695                 2700             


Ala Cys  Ala Cys Gly Cys Gly  Gly Cys Cys Thr Gly  Ala Thr Gly 
    2705                 2710                 2715             


Ala Ala  Thr Cys Thr Gly Cys  Thr Gly Cys Gly Gly  Thr Cys Thr 
    2720                 2725                 2730             


Thr Ala  Thr Thr Thr Cys Ala  Gly Ala Gly Thr Gly  Ala Ala Cys 
    2735                 2740                 2745             


Ala Ala  Thr Cys Thr Gly Gly  Ala Thr Gly Thr Gly  Ala Ala Gly 
    2750                 2755                 2760             


Gly Thr  Gly Ala Ala Gly Ala  Gly Cys Ala Thr Cys  Ala Ala Cys 
    2765                 2770                 2775             


Gly Gly  Cys Gly Gly Cys Thr  Thr Cys Ala Cys Cys  Thr Cys Cys 
    2780                 2785                 2790             


Thr Thr  Thr Cys Thr Gly Cys  Gly Gly Ala Gly Ala  Ala Ala Gly 
    2795                 2800                 2805             


Thr Gly  Gly Ala Ala Gly Thr  Thr Thr Ala Ala Gly  Ala Ala Gly 
    2810                 2815                 2820             


Gly Ala  Gly Cys Gly Cys Ala  Ala Cys Ala Ala Gly  Gly Gly Cys 
    2825                 2830                 2835             


Thr Ala  Thr Ala Ala Gly Cys  Ala Cys Cys Ala Cys  Gly Cys Cys 
    2840                 2845                 2850             


Gly Ala  Gly Gly Ala Thr Gly  Cys Cys Cys Thr Gly  Ala Thr Cys 
    2855                 2860                 2865             


Ala Thr  Cys Gly Cys Cys Ala  Ala Thr Gly Cys Cys  Gly Ala Cys 
    2870                 2875                 2880             


Thr Thr  Cys Ala Thr Cys Thr  Thr Thr Ala Ala Gly  Gly Ala Gly 
    2885                 2890                 2895             


Thr Gly  Gly Ala Ala Gly Ala  Ala Gly Cys Thr Gly  Gly Ala Cys 
    2900                 2905                 2910             


Ala Ala  Gly Gly Cys Cys Ala  Ala Gly Ala Ala Ala  Gly Thr Gly 
    2915                 2920                 2925             


Ala Thr  Gly Gly Ala Gly Ala  Ala Cys Cys Ala Gly  Ala Thr Gly 
    2930                 2935                 2940             


Thr Thr  Cys Gly Ala Gly Gly  Ala Gly Ala Ala Gly  Cys Ala Gly 
    2945                 2950                 2955             


Gly Cys  Cys Gly Ala Gly Ala  Gly Cys Ala Thr Gly  Cys Cys Cys 
    2960                 2965                 2970             


Gly Ala  Gly Ala Thr Cys Gly  Ala Gly Ala Cys Ala  Gly Ala Gly 
    2975                 2980                 2985             


Cys Ala  Gly Gly Ala Gly Thr  Ala Cys Ala Ala Gly  Gly Ala Gly 
    2990                 2995                 3000             


Ala Thr  Thr Thr Thr Cys Ala  Thr Cys Ala Cys Ala  Cys Cys Thr 
    3005                 3010                 3015             


Cys Ala  Cys Cys Ala Gly Ala  Thr Cys Ala Ala Gly  Cys Ala Cys 
    3020                 3025                 3030             


Ala Thr  Cys Ala Ala Gly Gly  Ala Cys Thr Thr Cys  Ala Ala Gly 
    3035                 3040                 3045             


Gly Ala  Cys Thr Ala Cys Ala  Ala Gly Thr Ala Thr  Thr Cys Thr 
    3050                 3055                 3060             


Cys Ala  Cys Ala Gly Gly Gly  Thr Gly Gly Ala Thr  Ala Ala Gly 
    3065                 3070                 3075             


Ala Ala  Gly Cys Cys Cys Ala  Ala Cys Cys Gly Cys  Ala Ala Gly 
    3080                 3085                 3090             


Cys Thr  Gly Ala Thr Cys Ala  Ala Thr Gly Ala Cys  Ala Cys Cys 
    3095                 3100                 3105             


Cys Thr  Gly Thr Ala Thr Ala  Gly Cys Ala Cys Ala  Cys Gly Gly 
    3110                 3115                 3120             


Ala Ala  Gly Gly Ala Cys Gly  Ala Thr Ala Ala Gly  Gly Gly Cys 
    3125                 3130                 3135             


Ala Ala  Thr Ala Cys Cys Cys  Thr Gly Ala Thr Cys  Gly Thr Gly 
    3140                 3145                 3150             


Ala Ala  Cys Ala Ala Thr Cys  Thr Gly Ala Ala Cys  Gly Gly Cys 
    3155                 3160                 3165             


Cys Thr  Gly Thr Ala Cys Gly  Ala Cys Ala Ala Gly  Gly Ala Thr 
    3170                 3175                 3180             


Ala Ala  Thr Gly Ala Cys Ala  Ala Gly Cys Thr Gly  Ala Ala Gly 
    3185                 3190                 3195             


Ala Ala  Gly Cys Thr Gly Ala  Thr Cys Ala Ala Cys  Ala Ala Gly 
    3200                 3205                 3210             


Thr Cys  Thr Cys Cys Cys Gly  Ala Gly Ala Ala Gly  Cys Thr Gly 
    3215                 3220                 3225             


Cys Thr  Gly Ala Thr Gly Thr  Ala Cys Cys Ala Cys  Cys Ala Cys 
    3230                 3235                 3240             


Gly Ala  Thr Cys Cys Thr Cys  Ala Gly Ala Cys Ala  Thr Ala Thr 
    3245                 3250                 3255             


Cys Ala  Gly Ala Ala Gly Cys  Thr Gly Ala Ala Gly  Cys Thr Gly 
    3260                 3265                 3270             


Ala Thr  Cys Ala Thr Gly Gly  Ala Gly Cys Ala Gly  Thr Ala Cys 
    3275                 3280                 3285             


Gly Gly  Cys Gly Ala Cys Gly  Ala Gly Ala Ala Gly  Ala Ala Cys 
    3290                 3295                 3300             


Cys Cys  Ala Cys Thr Gly Thr  Ala Thr Ala Ala Gly  Thr Ala Cys 
    3305                 3310                 3315             


Thr Ala  Thr Gly Ala Gly Gly  Ala Gly Ala Cys Ala  Gly Gly Cys 
    3320                 3325                 3330             


Ala Ala  Cys Thr Ala Cys Cys  Thr Gly Ala Cys Ala  Ala Ala Gly 
    3335                 3340                 3345             


Thr Ala  Thr Ala Gly Cys Ala  Ala Gly Ala Ala Gly  Gly Ala Thr 
    3350                 3355                 3360             


Ala Ala  Thr Gly Gly Cys Cys  Cys Cys Gly Thr Gly  Ala Thr Cys 
    3365                 3370                 3375             


Ala Ala  Gly Ala Ala Gly Ala  Thr Cys Ala Ala Gly  Thr Ala Cys 
    3380                 3385                 3390             


Thr Ala  Thr Gly Gly Cys Ala  Ala Cys Ala Ala Gly  Cys Thr Gly 
    3395                 3400                 3405             


Ala Ala  Thr Gly Cys Cys Cys  Ala Cys Cys Thr Gly  Gly Ala Cys 
    3410                 3415                 3420             


Ala Thr  Cys Ala Cys Cys Gly  Ala Cys Gly Ala Thr  Thr Ala Cys 
    3425                 3430                 3435             


Cys Cys  Thr Ala Ala Cys Thr  Cys Thr Cys Gly Cys  Ala Ala Thr 
    3440                 3445                 3450             


Ala Ala  Gly Gly Thr Gly Gly  Thr Gly Ala Ala Gly  Cys Thr Gly 
    3455                 3460                 3465             


Ala Gly  Cys Cys Thr Gly Ala  Ala Gly Cys Cys Ala  Thr Ala Cys 
    3470                 3475                 3480             


Cys Gly  Gly Thr Thr Cys Gly  Ala Cys Gly Thr Gly  Thr Ala Cys 
    3485                 3490                 3495             


Cys Thr  Gly Gly Ala Cys Ala  Ala Cys Gly Gly Cys  Gly Thr Gly 
    3500                 3505                 3510             


Thr Ala  Thr Ala Ala Gly Thr  Thr Thr Gly Thr Gly  Ala Cys Ala 
    3515                 3520                 3525             


Gly Thr  Gly Ala Ala Gly Ala  Ala Thr Cys Thr Gly  Gly Ala Thr 
    3530                 3535                 3540             


Gly Thr  Gly Ala Thr Cys Ala  Ala Gly Ala Ala Gly  Gly Ala Gly 
    3545                 3550                 3555             


Ala Ala  Cys Thr Ala Cys Thr  Ala Thr Gly Ala Gly  Gly Thr Gly 
    3560                 3565                 3570             


Ala Ala  Cys Ala Gly Cys Ala  Ala Gly Thr Gly Cys  Thr Ala Cys 
    3575                 3580                 3585             


Gly Ala  Gly Gly Ala Gly Gly  Cys Cys Ala Ala Gly  Ala Ala Gly 
    3590                 3595                 3600             


Cys Thr  Gly Ala Ala Gly Ala  Ala Gly Ala Thr Cys  Ala Gly Cys 
    3605                 3610                 3615             


Ala Ala  Cys Cys Ala Gly Gly  Cys Cys Gly Ala Gly  Thr Thr Cys 
    3620                 3625                 3630             


Ala Thr  Cys Gly Cys Cys Thr  Cys Thr Thr Thr Thr  Thr Ala Cys 
    3635                 3640                 3645             


Ala Ala  Gly Ala Ala Thr Gly  Ala Cys Cys Thr Gly  Ala Thr Cys 
    3650                 3655                 3660             


Ala Ala  Gly Ala Thr Cys Ala  Ala Thr Gly Gly Cys  Gly Ala Gly 
    3665                 3670                 3675             


Cys Thr  Gly Thr Ala Thr Ala  Gly Ala Gly Thr Gly  Ala Thr Cys 
    3680                 3685                 3690             


Gly Gly  Cys Gly Thr Gly Ala  Ala Cys Ala Ala Thr  Gly Ala Thr 
    3695                 3700                 3705             


Cys Thr  Gly Cys Thr Gly Ala  Ala Cys Ala Gly Ala  Ala Thr Cys 
    3710                 3715                 3720             


Gly Ala  Ala Gly Thr Gly Ala  Ala Thr Ala Thr Gly  Ala Thr Cys 
    3725                 3730                 3735             


Gly Ala  Cys Ala Thr Cys Ala  Cys Cys Thr Ala Cys  Ala Gly Gly 
    3740                 3745                 3750             


Gly Ala  Gly Thr Ala Thr Cys  Thr Gly Gly Ala Gly  Ala Ala Cys 
    3755                 3760                 3765             


Ala Thr  Gly Ala Ala Thr Gly  Ala Thr Ala Ala Gly  Ala Gly Gly 
    3770                 3775                 3780             


Cys Cys  Cys Cys Cys Thr Cys  Ala Thr Ala Thr Cys  Ala Thr Cys 
    3785                 3790                 3795             


Ala Ala  Gly Ala Cys Cys Ala  Thr Cys Gly Cys Cys  Thr Cys Thr 
    3800                 3805                 3810             


Ala Ala  Gly Ala Cys Ala Cys  Ala Gly Ala Gly Cys  Ala Thr Cys 
    3815                 3820                 3825             


Ala Ala  Gly Ala Ala Gly Thr  Ala Cys Ala Gly Cys  Ala Cys Ala 
    3830                 3835                 3840             


Gly Ala  Cys Ala Thr Cys Cys  Thr Gly Gly Gly Gly  Ala Ala Cys 
    3845                 3850                 3855             


Cys Thr  Gly Thr Ala Thr Gly  Ala Ala Gly Thr Cys  Ala Ala Gly 
    3860                 3865                 3870             


Ala Gly  Cys Ala Ala Gly Ala  Ala Ala Cys Ala Thr  Cys Cys Thr 
    3875                 3880                 3885             


Cys Ala  Gly Ala Thr Thr Ala  Thr Cys Ala Ala Gly  Ala Ala Ala 
    3890                 3895                 3900             


Gly Gly  Cys Ser Gly Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu 
    3905                 3910                 3915             


Phe Glu  Pro Lys Lys Lys Arg  Lys Val 
    3920                 3925         


<210>  470
<211>  2135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  470

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1835                 1840                 1845             


Gly Gly  Phe Ser Lys Glu Ser  Ile Arg Pro Lys Arg  Asn Ser Asp 
    1850                 1855                 1860             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1865                 1870                 1875             


Gly Phe  Val Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1880                 1885                 1890             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1895                 1900                 1905             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1910                 1915                 1920             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1925                 1930                 1935             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1940                 1945                 1950             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Arg Phe  Leu Gln Lys 
    1955                 1960                 1965             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1970                 1975                 1980             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1985                 1990                 1995             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2000                 2005                 2010             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2015                 2020                 2025             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2030                 2035                 2040             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2045                 2050                 2055             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Arg Ala Phe  Lys Tyr Phe 
    2060                 2065                 2070             


Asp Thr  Thr Ile Asp Arg Lys  Val Tyr Arg Ser Thr  Lys Glu Val 
    2075                 2080                 2085             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2090                 2095                 2100             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2105                 2110                 2115             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  471
<211>  2155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  471

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Ile Met Asn Phe 
            740                 745                 750         


Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro 
        755                 760                 765             


Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly 
    770                 775                 780                 


Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn 
785                 790                 795                 800 


Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser 
                805                 810                 815     


Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp 
            820                 825                 830         


Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr 
        835                 840                 845             


Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu 
    850                 855                 860                 


Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 
865                 870                 875                 880 


Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 
                885                 890                 895     


Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu 
            900                 905                 910         


Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln 
        915                 920                 925             


Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr 
    930                 935                 940                 


Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu 
945                 950                 955                 960 


Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile 
                965                 970                 975     


Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala 
            980                 985                 990         


Asn Leu Asp Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
        995                 1000                 1005             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1010                 1015                 1020             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1025                 1030                 1035             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1040                 1045                 1050             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1055                 1060                 1065             


Leu Ser  Gln Leu Gly Gly Asp  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1070                 1075                 1080             


Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser Gly Gly  Asp Lys Lys 
    1085                 1090                 1095             


Tyr Ser  Ile Gly Leu Ala Ile  Gly Thr Asn Ser Val  Gly Trp Ala 
    1100                 1105                 1110             


Val Ile  Thr Asp Glu Tyr Lys  Val Pro Ser Lys Lys  Phe Lys Val 
    1115                 1120                 1125             


Leu Gly  Asn Thr Asp Arg His  Ser Ile Lys Lys Asn  Leu Ile Gly 
    1130                 1135                 1140             


Ala Leu  Leu Phe Asp Ser Gly  Glu Thr Ala Glu Ala  Thr Arg Leu 
    1145                 1150                 1155             


Lys Arg  Thr Ala Arg Arg Arg  Tyr Thr Arg Arg Lys  Asn Arg Ile 
    1160                 1165                 1170             


Cys Tyr  Leu Gln Glu Ile Phe  Ser Asn Glu Met Ala  Lys Val Asp 
    1175                 1180                 1185             


Asp Ser  Phe Phe His Arg Leu  Glu Glu Ser Phe Leu  Val Glu Glu 
    1190                 1195                 1200             


Asp Lys  Lys His Glu Arg His  Pro Ile Phe Gly Asn  Ile Val Asp 
    1205                 1210                 1215             


Glu Val  Ala Tyr His Glu Lys  Tyr Pro Thr Ile Tyr  His Leu Arg 
    1220                 1225                 1230             


Lys Lys  Leu Val Asp Ser Thr  Asp Lys Ala Asp Leu  Arg Leu Ile 
    1235                 1240                 1245             


Tyr Leu  Ala Leu Ala His Met  Ile Lys Phe Arg Gly  His Phe Leu 
    1250                 1255                 1260             


Ile Glu  Gly Asp Leu Asn Pro  Asp Asn Ser Asp Val  Asp Lys Leu 
    1265                 1270                 1275             


Phe Ile  Gln Leu Val Gln Thr  Tyr Asn Gln Leu Phe  Glu Glu Asn 
    1280                 1285                 1290             


Pro Ile  Asn Ala Ser Gly Val  Asp Ala Lys Ala Ile  Leu Ser Ala 
    1295                 1300                 1305             


Arg Leu  Ser Lys Ser Arg Arg  Leu Glu Asn Leu Ile  Ala Gln Leu 
    1310                 1315                 1320             


Pro Gly  Glu Lys Lys Asn Gly  Leu Phe Gly Asn Leu  Ile Ala Leu 
    1325                 1330                 1335             


Ser Leu  Gly Leu Thr Pro Asn  Phe Lys Ser Asn Phe  Asp Leu Ala 
    1340                 1345                 1350             


Glu Asp  Ala Lys Leu Gln Leu  Ser Lys Asp Thr Tyr  Asp Asp Asp 
    1355                 1360                 1365             


Leu Asp  Asn Leu Leu Ala Gln  Ile Gly Asp Gln Tyr  Ala Asp Leu 
    1370                 1375                 1380             


Phe Leu  Ala Ala Lys Asn Leu  Ser Asp Ala Ile Leu  Leu Ser Asp 
    1385                 1390                 1395             


Ile Leu  Arg Val Asn Thr Glu  Ile Thr Lys Ala Pro  Leu Ser Ala 
    1400                 1405                 1410             


Ser Met  Ile Lys Arg Tyr Asp  Glu His His Gln Asp  Leu Thr Leu 
    1415                 1420                 1425             


Leu Lys  Ala Leu Val Arg Gln  Gln Leu Pro Glu Lys  Tyr Lys Glu 
    1430                 1435                 1440             


Ile Phe  Phe Asp Gln Ser Lys  Asn Gly Tyr Ala Gly  Tyr Ile Asp 
    1445                 1450                 1455             


Gly Gly  Ala Ser Gln Glu Glu  Phe Tyr Lys Phe Ile  Lys Pro Ile 
    1460                 1465                 1470             


Leu Glu  Lys Met Asp Gly Thr  Glu Glu Leu Leu Val  Lys Leu Asn 
    1475                 1480                 1485             


Arg Glu  Asp Leu Leu Arg Lys  Gln Arg Thr Phe Asp  Asn Gly Ser 
    1490                 1495                 1500             


Ile Pro  His Gln Ile His Leu  Gly Glu Leu His Ala  Ile Leu Arg 
    1505                 1510                 1515             


Arg Gln  Glu Asp Phe Tyr Pro  Phe Leu Lys Asp Asn  Arg Glu Lys 
    1520                 1525                 1530             


Ile Glu  Lys Ile Leu Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro 
    1535                 1540                 1545             


Leu Ala  Arg Gly Asn Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser 
    1550                 1555                 1560             


Glu Glu  Thr Ile Thr Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys 
    1565                 1570                 1575             


Gly Ala  Ser Ala Gln Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp 
    1580                 1585                 1590             


Lys Asn  Leu Pro Asn Glu Lys  Val Leu Pro Lys His  Ser Leu Leu 
    1595                 1600                 1605             


Tyr Glu  Tyr Phe Thr Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr 
    1610                 1615                 1620             


Val Thr  Glu Gly Met Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln 
    1625                 1630                 1635             


Lys Lys  Ala Ile Val Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val 
    1640                 1645                 1650             


Thr Val  Lys Gln Leu Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys 
    1655                 1660                 1665             


Phe Asp  Ser Val Glu Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala 
    1670                 1675                 1680             


Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys 
    1685                 1690                 1695             


Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile 
    1700                 1705                 1710             


Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu 
    1715                 1720                 1725             


Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp Asp Lys  Val Met Lys 
    1730                 1735                 1740             


Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg 
    1745                 1750                 1755             


Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile 
    1760                 1765                 1770             


Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met 
    1775                 1780                 1785             


Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln 
    1790                 1795                 1800             


Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser Leu His  Glu His Ile 
    1805                 1810                 1815             


Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln 
    1820                 1825                 1830             


Thr Val  Lys Val Val Asp Glu  Leu Val Lys Val Met  Gly Arg His 
    1835                 1840                 1845             


Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr 
    1850                 1855                 1860             


Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile 
    1865                 1870                 1875             


Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His 
    1880                 1885                 1890             


Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr 
    1895                 1900                 1905             


Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp 
    1910                 1915                 1920             


Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp His Ile  Val Pro Gln 
    1925                 1930                 1935             


Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg 
    1940                 1945                 1950             


Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu 
    1955                 1960                 1965             


Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala 
    1970                 1975                 1980             


Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu 
    1985                 1990                 1995             


Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg 
    2000                 2005                 2010             


Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys His Val  Ala Gln Ile 
    2015                 2020                 2025             


Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu 
    2030                 2035                 2040             


Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser 
    2045                 2050                 2055             


Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn 
    2060                 2065                 2070             


Asn Tyr  His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Val Gly 
    2075                 2080                 2085             


Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
    2090                 2095                 2100             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    2105                 2110                 2115             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    2120                 2125                 2130             


Ser Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    2135                 2140                 2145             


Pro Lys  Lys Lys Arg Lys Val  
    2150                 2155 


<210>  472
<211>  2156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  472

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Ile Gly Lys Ala 
            740                 745                 750         


Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr 
        755                 760                 765             


Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu 
    770                 775                 780                 


Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe 
785                 790                 795                 800 


Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys 
                805                 810                 815     


Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro 
            820                 825                 830         


Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 
        835                 840                 845             


Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu 
    850                 855                 860                 


Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val 
865                 870                 875                 880 


Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys 
                885                 890                 895     


Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys 
            900                 905                 910         


Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn 
        915                 920                 925             


Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn 
    930                 935                 940                 


Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser 
945                 950                 955                 960 


His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln 
                965                 970                 975     


Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln 
            980                 985                 990         


Ile Ser Glu Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
        995                 1000                 1005             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1010                 1015                 1020             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1025                 1030                 1035             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1040                 1045                 1050             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1055                 1060                 1065             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1070                 1075                 1080             


Gln Leu  Gly Gly Asp Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1085                 1090                 1095             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Met Asp  Lys Lys Tyr 
    1100                 1105                 1110             


Ser Ile  Gly Leu Ala Ile Gly  Thr Asn Ser Val Gly  Trp Ala Val 
    1115                 1120                 1125             


Ile Thr  Asp Glu Tyr Lys Val  Pro Ser Lys Lys Phe  Lys Val Leu 
    1130                 1135                 1140             


Gly Asn  Thr Asp Arg His Ser  Ile Lys Lys Asn Leu  Ile Gly Ala 
    1145                 1150                 1155             


Leu Leu  Phe Asp Ser Gly Glu  Thr Ala Glu Ala Thr  Arg Leu Lys 
    1160                 1165                 1170             


Arg Thr  Ala Arg Arg Arg Tyr  Thr Arg Arg Lys Asn  Arg Ile Cys 
    1175                 1180                 1185             


Tyr Leu  Gln Glu Ile Phe Ser  Asn Glu Met Ala Lys  Val Asp Asp 
    1190                 1195                 1200             


Ser Phe  Phe His Arg Leu Glu  Glu Ser Phe Leu Val  Glu Glu Asp 
    1205                 1210                 1215             


Lys Lys  His Glu Arg His Pro  Ile Phe Gly Asn Ile  Val Asp Glu 
    1220                 1225                 1230             


Val Ala  Tyr His Glu Lys Tyr  Pro Thr Ile Tyr His  Leu Arg Lys 
    1235                 1240                 1245             


Lys Leu  Val Asp Ser Thr Asp  Lys Ala Asp Leu Arg  Leu Ile Tyr 
    1250                 1255                 1260             


Leu Ala  Leu Ala His Met Ile  Lys Phe Arg Gly His  Phe Leu Ile 
    1265                 1270                 1275             


Glu Gly  Asp Leu Asn Pro Asp  Asn Ser Asp Val Asp  Lys Leu Phe 
    1280                 1285                 1290             


Ile Gln  Leu Val Gln Thr Tyr  Asn Gln Leu Phe Glu  Glu Asn Pro 
    1295                 1300                 1305             


Ile Asn  Ala Ser Gly Val Asp  Ala Lys Ala Ile Leu  Ser Ala Arg 
    1310                 1315                 1320             


Leu Ser  Lys Ser Arg Arg Leu  Glu Asn Leu Ile Ala  Gln Leu Pro 
    1325                 1330                 1335             


Gly Glu  Lys Lys Asn Gly Leu  Phe Gly Asn Leu Ile  Ala Leu Ser 
    1340                 1345                 1350             


Leu Gly  Leu Thr Pro Asn Phe  Lys Ser Asn Phe Asp  Leu Ala Glu 
    1355                 1360                 1365             


Asp Ala  Lys Leu Gln Leu Ser  Lys Asp Thr Tyr Asp  Asp Asp Leu 
    1370                 1375                 1380             


Asp Asn  Leu Leu Ala Gln Ile  Gly Asp Gln Tyr Ala  Asp Leu Phe 
    1385                 1390                 1395             


Leu Ala  Ala Lys Asn Leu Ser  Asp Ala Ile Leu Leu  Ser Asp Ile 
    1400                 1405                 1410             


Leu Arg  Val Asn Thr Glu Ile  Thr Lys Ala Pro Leu  Ser Ala Ser 
    1415                 1420                 1425             


Met Ile  Lys Arg Tyr Asp Glu  His His Gln Asp Leu  Thr Leu Leu 
    1430                 1435                 1440             


Lys Ala  Leu Val Arg Gln Gln  Leu Pro Glu Lys Tyr  Lys Glu Ile 
    1445                 1450                 1455             


Phe Phe  Asp Gln Ser Lys Asn  Gly Tyr Ala Gly Tyr  Ile Asp Gly 
    1460                 1465                 1470             


Gly Ala  Ser Gln Glu Glu Phe  Tyr Lys Phe Ile Lys  Pro Ile Leu 
    1475                 1480                 1485             


Glu Lys  Met Asp Gly Thr Glu  Glu Leu Leu Val Lys  Leu Asn Arg 
    1490                 1495                 1500             


Glu Asp  Leu Leu Arg Lys Gln  Arg Thr Phe Asp Asn  Gly Ser Ile 
    1505                 1510                 1515             


Pro His  Gln Ile His Leu Gly  Glu Leu His Ala Ile  Leu Arg Arg 
    1520                 1525                 1530             


Gln Glu  Asp Phe Tyr Pro Phe  Leu Lys Asp Asn Arg  Glu Lys Ile 
    1535                 1540                 1545             


Glu Lys  Ile Leu Thr Phe Arg  Ile Pro Tyr Tyr Val  Gly Pro Leu 
    1550                 1555                 1560             


Ala Arg  Gly Asn Ser Arg Phe  Ala Trp Met Thr Arg  Lys Ser Glu 
    1565                 1570                 1575             


Glu Thr  Ile Thr Pro Trp Asn  Phe Glu Glu Val Val  Asp Lys Gly 
    1580                 1585                 1590             


Ala Ser  Ala Gln Ser Phe Ile  Glu Arg Met Thr Asn  Phe Asp Lys 
    1595                 1600                 1605             


Asn Leu  Pro Asn Glu Lys Val  Leu Pro Lys His Ser  Leu Leu Tyr 
    1610                 1615                 1620             


Glu Tyr  Phe Thr Val Tyr Asn  Glu Leu Thr Lys Val  Lys Tyr Val 
    1625                 1630                 1635             


Thr Glu  Gly Met Arg Lys Pro  Ala Phe Leu Ser Gly  Glu Gln Lys 
    1640                 1645                 1650             


Lys Ala  Ile Val Asp Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr 
    1655                 1660                 1665             


Val Lys  Gln Leu Lys Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe 
    1670                 1675                 1680             


Asp Ser  Val Glu Ile Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser 
    1685                 1690                 1695             


Leu Gly  Thr Tyr His Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp 
    1700                 1705                 1710             


Phe Leu  Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
    1715                 1720                 1725             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1730                 1735                 1740             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1745                 1750                 1755             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1760                 1765                 1770             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1775                 1780                 1785             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1790                 1795                 1800             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1805                 1810                 1815             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1820                 1825                 1830             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1835                 1840                 1845             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1850                 1855                 1860             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1865                 1870                 1875             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1880                 1885                 1890             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1895                 1900                 1905             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1910                 1915                 1920             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1925                 1930                 1935             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1940                 1945                 1950             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1955                 1960                 1965             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1970                 1975                 1980             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1985                 1990                 1995             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    2000                 2005                 2010             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    2015                 2020                 2025             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    2030                 2035                 2040             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    2045                 2050                 2055             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    2060                 2065                 2070             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    2075                 2080                 2085             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    2090                 2095                 2100             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    2105                 2110                 2115             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    2120                 2125                 2130             


Glu Gln  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    2135                 2140                 2145             


Glu Pro  Lys Lys Lys Arg Lys  Val 
    2150                 2155     


<210>  473
<211>  1994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  473

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys 
            740                 745                 750         


Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile 
        755                 760                 765             


Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val 
    770                 775                 780                 


Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu 
785                 790                 795                 800 


Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys 
                805                 810                 815     


Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg 
            820                 825                 830         


Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg 
        835                 840                 845             


Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu 
    850                 855                 860                 


Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp 
865                 870                 875                 880 


Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala 
                885                 890                 895     


Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala 
            900                 905                 910         


Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg 
        915                 920                 925             


Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp 
    930                 935                 940                 


Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr 
945                 950                 955                 960 


Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr 
                965                 970                 975     


Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr 
            980                 985                 990         


Glu Ser Gly Glu Lys Ile Lys Gly  Leu Asn Glu Tyr Ile  Asn Leu Tyr 
        995                 1000                 1005             


Asn Gln  Lys Thr Lys Gln Lys  Leu Pro Lys Phe Lys  Pro Leu Tyr 
    1010                 1015                 1020             


Lys Gln  Val Leu Ser Asp Arg  Glu Ser Leu Ser Phe  Tyr Gly Glu 
    1025                 1030                 1035             


Gly Tyr  Thr Ser Asp Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr 
    1040                 1045                 1050             


Leu Asn  Lys Asn Ser Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu 
    1055                 1060                 1065             


Lys Leu  Phe Lys Asn Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe 
    1070                 1075                 1080             


Val Lys  Asn Gly Pro Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe 
    1085                 1090                 1095             


Gly Glu  Trp Asn Val Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp 
    1100                 1105                 1110             


Asp Ile  His Leu Lys Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu 
    1115                 1120                 1125             


Asp Asp  Arg Arg Lys Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu 
    1130                 1135                 1140             


Glu Gln  Leu Gln Glu Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu 
    1145                 1150                 1155             


Lys Leu  Lys Glu Ile Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys 
    1160                 1165                 1170             


Val Tyr  Gly Ser Ser Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu 
    1175                 1180                 1185             


Glu Lys  Ser Leu Lys Lys Asn  Asp Ala Val Val Ala  Ile Met Lys 
    1190                 1195                 1200             


Asp Leu  Leu Asp Ser Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala 
    1205                 1210                 1215             


Phe Phe  Gly Glu Gly Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr 
    1220                 1225                 1230             


Gly Asp  Phe Val Leu Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His 
    1235                 1240                 1245             


Ile Tyr  Asp Ala Ile Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser 
    1250                 1255                 1260             


Lys Asp  Lys Phe Lys Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Gly 
    1265                 1270                 1275             


Gly Trp  Asp Lys Asp Lys Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu 
    1280                 1285                 1290             


Arg Tyr  Gly Ser Lys Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr 
    1295                 1300                 1305             


Ala Lys  Cys Leu Gln Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn 
    1310                 1315                 1320             


Tyr Glu  Lys Ile Asn Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met 
    1325                 1330                 1335             


Leu Pro  Lys Val Phe Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn 
    1340                 1345                 1350             


Pro Ser  Glu Asp Ile Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys 
    1355                 1360                 1365             


Lys Gly  Asp Met Phe Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp 
    1370                 1375                 1380             


Phe Phe  Lys Asp Ser Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala 
    1385                 1390                 1395             


Tyr Asp  Phe Asn Phe Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala 
    1400                 1405                 1410             


Gly Phe  Tyr Arg Glu Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe 
    1415                 1420                 1425             


Glu Ser  Ala Ser Lys Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly 
    1430                 1435                 1440             


Lys Leu  Tyr Met Phe Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys 
    1445                 1450                 1455             


Ser His  Gly Thr Pro Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu 
    1460                 1465                 1470             


Phe Asp  Glu Asn Asn His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala 
    1475                 1480                 1485             


Glu Leu  Phe Met Arg Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val 
    1490                 1495                 1500             


Val His  Pro Ala Asn Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn 
    1505                 1510                 1515             


Pro Lys  Lys Thr Thr Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys 
    1520                 1525                 1530             


Arg Phe  Ser Glu Asp Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile 
    1535                 1540                 1545             


Asn Lys  Cys Pro Lys Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg 
    1550                 1555                 1560             


Val Leu  Leu Lys His Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Ala 
    1565                 1570                 1575             


Arg Gly  Glu Arg Asn Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys 
    1580                 1585                 1590             


Gly Asn  Ile Val Glu Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn 
    1595                 1600                 1605             


Phe Asn  Gly Ile Arg Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp 
    1610                 1615                 1620             


Lys Lys  Glu Lys Glu Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser 
    1625                 1630                 1635             


Ile Glu  Asn Ile Lys Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val 
    1640                 1645                 1650             


Val His  Lys Ile Cys Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile 
    1655                 1660                 1665             


Ala Leu  Glu Asp Leu Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys 
    1670                 1675                 1680             


Val Glu  Lys Gln Val Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp 
    1685                 1690                 1695             


Lys Leu  Asn Tyr Met Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr 
    1700                 1705                 1710             


Gly Gly  Ala Leu Lys Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser 
    1715                 1720                 1725             


Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro 
    1730                 1735                 1740             


Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn 
    1745                 1750                 1755             


Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe 
    1760                 1765                 1770             


Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu 
    1775                 1780                 1785             


Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala 
    1790                 1795                 1800             


Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile 
    1805                 1810                 1815             


Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu 
    1820                 1825                 1830             


Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr 
    1835                 1840                 1845             


Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu 
    1850                 1855                 1860             


Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser 
    1865                 1870                 1875             


Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr Gly Arg  Thr Asp Val 
    1880                 1885                 1890             


Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr 
    1895                 1900                 1905             


Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys 
    1910                 1915                 1920             


Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu 
    1925                 1930                 1935             


Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp 
    1940                 1945                 1950             


Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala 
    1955                 1960                 1965             


Gln Thr  Ser Val Lys Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    1970                 1975                 1980             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1985                 1990                 


<210>  474
<211>  2135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  474

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1835                 1840                 1845             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1850                 1855                 1860             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1865                 1870                 1875             


Gly Phe  Val Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1880                 1885                 1890             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1895                 1900                 1905             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1910                 1915                 1920             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1925                 1930                 1935             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1940                 1945                 1950             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1955                 1960                 1965             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1970                 1975                 1980             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1985                 1990                 1995             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2000                 2005                 2010             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2015                 2020                 2025             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2030                 2035                 2040             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2045                 2050                 2055             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    2060                 2065                 2070             


Asp Thr  Thr Ile Asp Arg Lys  Gln Tyr Arg Ser Thr  Lys Glu Val 
    2075                 2080                 2085             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2090                 2095                 2100             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2105                 2110                 2115             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  475
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  475
ccttccagag attctggggc                                                   20


<210>  476
<211>  1866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  476

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Thr Thr Gly Ala Thr Gly 
    210                 215                 220                 


Gly Ala Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Thr Cys Thr 
225                 230                 235                 240 


Thr Cys Thr Gly Ala Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Thr Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Gly Ala 
            260                 265                 270         


Thr Ala Gly Ala Ala Ala Thr Cys Gly Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Gly Cys Gly Gly Cys Ala Cys Ala Thr Thr Cys Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Cys Ala Gly Gly Ala Thr Thr Cys Cys Cys Thr Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Ala Thr Thr Thr Cys Gly Ala Cys Gly Cys Gly Gly Thr 
                325                 330                 335     


Gly Ala Thr Thr Cys Ala Thr Gly Cys Cys Gly Gly Gly Gly Thr Ala 
            340                 345                 350         


Gly Thr Thr Cys Ala Gly Cys Ala Cys Gly Thr Thr Cys Ala Thr Cys 
        355                 360                 365             


Ala Gly Gly Gly Ala Gly Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys 
    370                 375                 380                 


Cys Thr Cys Thr Thr Thr Thr Thr Gly Ala Gly Thr Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala Cys Gly Cys Cys Ala Ala Ala Cys Ala Cys Cys Ala Cys Gly 
                405                 410                 415     


Cys Gly Gly Cys Cys Gly Ala Thr Cys Cys Thr Ala Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Gly Gly Cys 
        435                 440                 445             


Gly Cys Ala Cys Ala Thr Cys Ala Cys Gly Cys Ala Ala Gly Gly Cys 
    450                 455                 460                 


Thr Cys Gly Ala Ala Thr Gly Thr Cys Ala Cys Gly Thr Ala Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Gly Cys Gly Thr Cys Ala Ala Thr Cys Ala Gly 
                485                 490                 495     


Thr Cys Thr Gly Thr Ala Gly Thr Thr Cys Thr Gly Cys Ala Thr Gly 
            500                 505                 510         


Ala Cys Cys Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Thr Cys 
        515                 520                 525             


Thr Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Ala Thr Thr Thr Cys 
    530                 535                 540                 


Gly Gly Cys Ala Thr Gly Gly Gly Cys Thr Gly Thr Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Cys Gly Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr Gly Gly 
                565                 570                 575     


Cys Thr Cys Thr Gly Thr Thr Cys Cys Ala Gly Cys Cys Cys Thr Cys 
            580                 585                 590         


Gly Cys Cys Gly Ala Thr Cys Ala Cys Thr Cys Thr Ala Thr Thr Gly 
        595                 600                 605             


Thr Thr Cys Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Cys Cys Ala Cys Ala Gly Gly Cys Ala Cys Cys Thr Cys 
625                 630                 635                 640 


Cys Cys Thr Cys Thr Cys Ala Thr Cys Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Thr Cys Ala 
            660                 665                 670         


Gly Gly Gly Cys Ala Thr Gly Thr Cys Thr Cys Ala Thr Cys Cys Ala 
        675                 680                 685             


Gly Thr Ala Cys Thr Cys Gly Thr Gly Gly Gly Ala Ala Ala Ala Cys 
    690                 695                 700                 


Thr Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                725                 730                 735     


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser 
            740                 745                 750         


Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
        755                 760                 765             


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
    770                 775                 780                 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
785                 790                 795                 800 


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
                805                 810                 815     


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
            820                 825                 830         


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
        835                 840                 845             


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
    850                 855                 860                 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
865                 870                 875                 880 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
                885                 890                 895     


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
            900                 905                 910         


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
        915                 920                 925             


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
    930                 935                 940                 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
945                 950                 955                 960 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
                965                 970                 975     


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
            980                 985                 990         


Gly Leu Thr Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
        995                 1000                 1005             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1025                 1030                 1035             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1040                 1045                 1050             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1055                 1060                 1065             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1070                 1075                 1080             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1085                 1090                 1095             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1100                 1105                 1110             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1115                 1120                 1125             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1130                 1135                 1140             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1145                 1150                 1155             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1160                 1165                 1170             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1175                 1180                 1185             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1190                 1195                 1200             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1205                 1210                 1215             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1220                 1225                 1230             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1235                 1240                 1245             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1250                 1255                 1260             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1265                 1270                 1275             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1280                 1285                 1290             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1295                 1300                 1305             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1310                 1315                 1320             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1325                 1330                 1335             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1340                 1345                 1350             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1355                 1360                 1365             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1370                 1375                 1380             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1385                 1390                 1395             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1400                 1405                 1410             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1415                 1420                 1425             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1430                 1435                 1440             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1445                 1450                 1455             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1460                 1465                 1470             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1475                 1480                 1485             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1490                 1495                 1500             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1505                 1510                 1515             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1520                 1525                 1530             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1535                 1540                 1545             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1550                 1555                 1560             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1565                 1570                 1575             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1580                 1585                 1590             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1595                 1600                 1605             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1610                 1615                 1620             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1625                 1630                 1635             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1640                 1645                 1650             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1655                 1660                 1665             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1670                 1675                 1680             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1685                 1690                 1695             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1700                 1705                 1710             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1715                 1720                 1725             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1730                 1735                 1740             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1745                 1750                 1755             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1760                 1765                 1770             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1775                 1780                 1785             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1790                 1795                 1800             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1805                 1810                 1815             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1820                 1825                 1830             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Ser Gly Gly 
    1835                 1840                 1845             


Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys 
    1850                 1855                 1860             


Arg Lys  Val 
    1865     


<210>  477
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  477
ccagccggtg cagggtgccc                                                   20


<210>  478
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  478
cagcggtaca gggtgaccac                                                   20


<210>  479
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  479
tgtccaggca ggaggccagg                                                   20


<210>  480
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  480
tgcccttgtg cacaatgccc                                                   20


<210>  481
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  481
ccaaatttgg atgttttcaa                                                   20


<210>  482
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  482
ctcggacaaa gttcgggctc                                                   20


<210>  483
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  483
caatgcagag tgaggttggt                                                   20


<210>  484
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  484
acgggatttt ttcatttctg                                                   20


<210>  485
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  485
aaaattcgca agtatgtctt                                                   20


<210>  486
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  486
cattgatgct ggcgcccggc                                                   20


<210>  487
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  487
atgtaataca cactgattgc                                                   20


<210>  488
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  488
ctgaagctgg tctgacctca                                                   20


<210>  489
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  489
acactaattc ctatgaatgt                                                   20


<210>  490
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  490
gaaatacgat ggggcgctca                                                   20


<210>  491
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  491
gaagcagagg cggtaggcgt                                                   20


<210>  492
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  492
gcttccgagg ctgcaccgca                                                   20


<210>  493
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  493
tggaatcctt ttatatttag                                                   20


<210>  494
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  494
gtccgcaacg ggctaatcca                                                   20


<210>  495
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  495
gggttttacg accagcagcg                                                   20


<210>  496
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  496
tcccacggaa tcctccagat                                                   20


<210>  497
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  497
cagctaccgg acgctggacc                                                   20


<210>  498
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  498
tccgggagat gaaatgggat                                                   20


<210>  499
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  499
tcccgctgga cggctccgag                                                   20


<210>  500
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  500
ggacaatccg gtggagcgcc                                                   20


<210>  501
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  501
aggagcgcta tttagcatcg                                                   20


<210>  502
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  502
caccattggc cgcacactgg                                                   20


<210>  503
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  503
aataggagca ggggctcagc                                                   20


<210>  504
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  504
cttgttacag taatagctgt                                                   20


<210>  505
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  505
agcgtggggt atgccgttgt                                                   20


<210>  506
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  506
aaagtaccgg atgaccctct                                                   20


<210>  507
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  507
gccgaacgca tcaacactgc                                                   20


<210>  508
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  508
ctccatggtg tgggcgcagg                                                   20


<210>  509
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  509
ccctgtcttt ggcagcgaaa                                                   20


<210>  510
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  510
attttggtac ctttgtcccc                                                   20


<210>  511
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  511
cagcagagct tgcggcgccg                                                   20


<210>  512
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  512
atccattcct gaatggaaca                                                   20


<210>  513
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  513
gaggtactcg gcagatcctt                                                   20


<210>  514
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  514
tgtacaggcc acattgagat                                                   20


<210>  515
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  515
agtcagtacc tgcctgccca                                                   20


<210>  516
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  516
atagacagtg gctgcacttc                                                   20


<210>  517
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  517
gacaggccca tgaaaaccag                                                   20


<210>  518
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  518
tccggaggag gtgaaggcca                                                   20


<210>  519
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  519
atagcggatc agggagaagt                                                   20


<210>  520
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  520
tacccggata tcaagaactt                                                   20


<210>  521
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  521
tagagctctg cttgaaacat                                                   20


<210>  522
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  522
cggagggtga ggagtgcagg                                                   20


<210>  523
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  523
ggcgatgtca tcacctttga                                                   20


<210>  524
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  524
agtggccgta cagggagatt                                                   20


<210>  525
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  525
gtcgagacgc tggccagcta                                                   20


<210>  526
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  526
gtgacggtga gctctgcaaa                                                   20


<210>  527
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  527
tttctaccgc agcaggctac                                                   20


<210>  528
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  528
gcaggtacct ggggggcgcc                                                   20


<210>  529
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  529
gtggagacgg acgctgcacc                                                   20


<210>  530
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  530
gtagtaccgt gggtactcga                                                   20


<210>  531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  531
tgtttctaac gggaccactg                                                   20


<210>  532
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  532
ggaattccgg gagatgaaat                                                   20


<210>  533
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  533
ccaccgtggt ttacaccgac                                                   20


<210>  534
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  534
acggcactgg gggtcttgtt                                                   20


<210>  535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  535
gttcccagtg ggcacagagg                                                   20


<210>  536
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  536
aaggcgtggg gaagcattaa                                                   20


<210>  537
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  537
tgagccggtg ggcccaatgc                                                   20


<210>  538
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  538
aggtcgtgta aaatggataa                                                   20


<210>  539
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  539
tatgaccggc ggctggagcc                                                   20


<210>  540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  540
ctacaattcc tacctgtccg                                                   20


<210>  541
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  541
gttgaatctg tgtgtaaacg                                                   20


<210>  542
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  542
acactgagtg gtacaagaac                                                   20


<210>  543
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  543
actaacctgg ggctgccctt                                                   20


<210>  544
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  544
gattaccatc cctccattcc                                                   20


<210>  545
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  545
ttcactgtgg tcattttcct                                                   20


<210>  546
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  546
gcatgtccta catcccgcag                                                   20


<210>  547
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  547
tacagacgtg aatgcttccc                                                   20


<210>  548
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  548
gaaaccgtag aggcagctgc                                                   20


<210>  549
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  549
gaaatagtac ctttcttgaa                                                   20


<210>  550
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  550
agacgatggg gggccgcagc                                                   20


<210>  551
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  551
ggtgttgctg gaatggagaa                                                   20


<210>  552
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  552
cctgaaaagc ccaaactccc                                                   20


<210>  553
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  553
gtacgtgcct gtgaacggca                                                   20


<210>  554
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  554
aacctcatgg gattcaactg                                                   20


<210>  555
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  555
aacgtgaaag agatgcctgt                                                   20


<210>  556
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  556
gtgctgccgg gcatattttc                                                   20


<210>  557
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  557
cgacaggccc atgaaaacca                                                   20


<210>  558
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  558
accggacatc ctcagtgccg                                                   20


<210>  559
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  559
taactgtgcc catggccatt                                                   20


<210>  560
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  560
cagggctgag gggagaggac                                                   20


<210>  561
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  561
gacgcgggcg accgggtaag                                                   20


<210>  562
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  562
gatcatgccg tcgtacaagg                                                   20


<210>  563
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  563
gaacgctgtc caccgtggag                                                   20


<210>  564
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  564
gagtttcgct cttgtcgccc                                                   20


<210>  565
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  565
gctgtcctct ccagctccag                                                   20


<210>  566
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  566
tctgcgggca gctggtcttc                                                   20


<210>  567
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  567
gacagaaagt ggtagcaaag                                                   20


<210>  568
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  568
acgtttctgc tgatcgtgct                                                   20


<210>  569
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  569
ctgtgtgcgc cagggctgtg                                                   20


<210>  570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  570
tggaagatct atgaggaatg                                                   20


<210>  571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  571
tcaagcggtt caagggcaaa                                                   20


<210>  572
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  572
atcactgctg acggtggagt                                                   20


<210>  573
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  573
tatctgtgcg agggtgctcg                                                   20


<210>  574
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  574
aaccgaaggc tggtggccac                                                   20


<210>  575
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  575
ggcgggtaga gggtctgcag                                                   20


<210>  576
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  576
tgccggaggg tgaggagtgc                                                   20


<210>  577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  577
aaggactccc cttgcaataa                                                   20


<210>  578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  578
aaaacgtgtt ggtgcttgag                                                   20


<210>  579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  579
tttggttggc cctgttggct                                                   20


<210>  580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  580
gacgaggatc tctagggtgg                                                   20


<210>  581
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  581
tccgagtcag atctgcaatc                                                   20


<210>  582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  582
cacagtgggc aagacctctc                                                   20


<210>  583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  583
aagtagcata aatttgtgca                                                   20


<210>  584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  584
aaacagaaag cggacaatca                                                   20


<210>  585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  585
tcaccgagaa ggtgcctctt                                                   20


<210>  586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  586
atcgcggact acaacatcat                                                   20


<210>  587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  587
aagtatgtgc ggagcgcctc                                                   20


<210>  588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  588
tggggcttcc tctcgggccg                                                   20


<210>  589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  589
acggtagtaa gtagccacat                                                   20


<210>  590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  590
ctgtgaagac ttcgaacagc                                                   20


<210>  591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  591
gaggtgcgca ggcgcgtgtg                                                   20


<210>  592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  592
gtagaagcag attttctgcc                                                   20


<210>  593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  593
ggctaagggc cacggcaaga                                                   20


<210>  594
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  594
gctgaactgc agggggcatg                                                   20


<210>  595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  595
agagcaagcg tagacagccg                                                   20


<210>  596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  596
tacgtgcctg tgaacggcaa                                                   20


<210>  597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  597
gtgcggaaga aaaactcagt                                                   20


<210>  598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  598
gaacgtgaaa gagatgcctg                                                   20


<210>  599
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  599
ccaatgtcac tgtggtggac                                                   20


<210>  600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  600
gaaaacgtgt tggtgcttga                                                   20


<210>  601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  601
ctgcgtgact ccgactggac                                                   20


<210>  602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  602
cggactacaa catcattggc                                                   20


<210>  603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  603
acagatggaa gctatctgaa                                                   20


<210>  604
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  604
tggatacgtc ccagtatttt                                                   20


<210>  605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  605
tgcagtaggt acgcggcggc                                                   20


<210>  606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  606
cccggatatc aagaactttg                                                   20


<210>  607
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  607
accgtacaaa aggacagcag                                                   20


<210>  608
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  608
catgcttctg ctgatcgtgc                                                   20


<210>  609
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  609
agaagcagag gcggtaggcg                                                   20


<210>  610
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  610
tctggccgga ccgaggaacc                                                   20


<210>  611
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  611
ggaggcaaac gggttccttg                                                   20


<210>  612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  612
cggccggaag ttcgagaagc                                                   20


<210>  613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  613
ttccgggccg ggaccgtgat                                                   20


<210>  614
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  614
tacactgggt gatcctgcaa                                                   20


<210>  615
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  615
ggttttacga ccagcagcga                                                   20


<210>  616
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  616
tgttgaggac ggaagagcag                                                   20


<210>  617
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  617
cacgtgcaac ctggcctttg                                                   20


<210>  618
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  618
ttcttcgcgg actgcaaaca                                                   20


<210>  619
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  619
gacggaagaa ggatgggcag                                                   20


<210>  620
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  620
tccgggtgtc atcagcttgt                                                   20


<210>  621
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  621
ctcaacggta cttgtgagcc                                                   20


<210>  622
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  622
ccgttcttca ggcccatcat                                                   20


<210>  623
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  623
aagcaagttt tggtttcatt                                                   20


<210>  624
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  624
tgtggtggac cggctgtcac                                                   20


<210>  625
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  625
ggcgctgctg ctgaagatgc                                                   20


<210>  626
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  626
ccgtataggc cacattgaga                                                   20


<210>  627
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  627
acgggcaaag aaggtgtcca                                                   20


<210>  628
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  628
acagtgcctg cacccagcgc                                                   20


<210>  629
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  629
ctggtggcaa cagacccgtc                                                   20


<210>  630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  630
gagcgtgggg tatgccgttg                                                   20


<210>  631
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  631
aaagaacctg tagatcaaag                                                   20


<210>  632
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  632
aggtagattc caatggcttc                                                   20


<210>  633
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  633
gtaagtgctg accaaattac                                                   20


<210>  634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  634
aagcatgtgt ggagcgcctc                                                   20


<210>  635
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  635
aggtcactag acatgaataa                                                   20


<210>  636
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  636
cgatggttgg cggtttagac                                                   20


<210>  637
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  637
agctgaattt gtgtgtaaac                                                   20


<210>  638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  638
acacagttct caaacactgt                                                   20


<210>  639
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  639
cactgatgtg ctccagggtc                                                   20


<210>  640
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  640
catccattcc tgaatggaac                                                   20


<210>  641
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  641
catcatgccc atcctggaag                                                   20


<210>  642
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  642
tcattgtcgt aggtaaagaa                                                   20


<210>  643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  643
aagtcacagt gcacggcaca                                                   20


<210>  644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  644
gaaggagacg gcctccatga                                                   20


<210>  645
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  645
gcaaggtgag gtggtgacaa                                                   20


<210>  646
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  646
tttggcacga atgaaaaggt                                                   20


<210>  647
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  647
agagggaaac ctttcatcag                                                   20


<210>  648
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  648
gtgtagcgta tgcttccagg                                                   20


<210>  649
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  649
aaactggccc ttatacctgt                                                   20


<210>  650
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  650
gatcactggt aactcagtag                                                   20


<210>  651
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  651
atatgcgcat ctgtggaccc                                                   20


<210>  652
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  652
ggaaatactg aaagcaaaga                                                   20


<210>  653
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  653
tgtgtgccgg cccatcactt                                                   20


<210>  654
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  654
cggcactggg ggtcttgttc                                                   20


<210>  655
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  655
ccaggcggtc cgcaaggccc                                                   20


<210>  656
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  656
ctgtggtgga ctggctgtca                                                   20


<210>  657
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  657
caccatcgat gtggccccct                                                   20


<210>  658
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  658
gtacctgcac tgggctgact                                                   20


<210>  659
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  659
caggcaactg gtttaagaac                                                   20


<210>  660
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  660
tagtaccgtg ggtactcgaa                                                   20


<210>  661
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  661
ggggccgtga cgaccagccc                                                   20


<210>  662
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  662
gaggtgagca atctgtcagc                                                   20


<210>  663
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  663
tgttgttact ggaattagtt                                                   20


<210>  664
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  664
gctggtactc gtaatccggg                                                   20


<210>  665
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  665
acagaaagtg gtagcaaagc                                                   20


<210>  666
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  666
cttccgggcc gggaccgtga                                                   20


<210>  667
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  667
gatggttccg ctccaggacc                                                   20


<210>  668
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  668
agaaggaacg ctgtccaccg                                                   20


<210>  669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  669
acgtgaatgc ttccctggac                                                   20


<210>  670
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  670
tttgtctgac aacaatacat                                                   20


<210>  671
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  671
gctggaatgg agaatggcct                                                   20


<210>  672
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  672
aggagaactt ctggatttgc                                                   20


<210>  673
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  673
gtgcctcatc aagctaccca                                                   20


<210>  674
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  674
atcccggaca gcttccccaa                                                   20


<210>  675
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  675
atgcttctgc tgatcgtgct                                                   20


<210>  676
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  676
cacctgtgac ggctctgagg                                                   20


<210>  677
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  677
ttacgcaatg gaacgcccga                                                   20


<210>  678
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  678
agtaccgtgg gtactcgaag                                                   20


<210>  679
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  679
cctcgtagta aatccagttc                                                   20


<210>  680
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  680
ccatgtggtg gaagagatat                                                   20


<210>  681
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  681
caaggtccgt gtcttttcct                                                   20


<210>  682
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  682
tcaacggtac ttgtgagcca                                                   20


<210>  683
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  683
aaccggttct acacgcgagc                                                   20


<210>  684
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  684
tggaatagcg tttgccacag                                                   20


<210>  685
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  685
tgacggaggg gatggcgcct                                                   20


<210>  686
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  686
caggaccagc atcatccccc                                                   20


<210>  687
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  687
agcgggcaag gtggcagaga                                                   20


<210>  688
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  688
tgtcactgaa gaccccgagc                                                   20


<210>  689
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  689
ttccgggggg cctcagggcg                                                   20


<210>  690
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  690
gcaggtgaac cgtttcccct                                                   20


<210>  691
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  691
tatgaacgtt ggtgtccctt                                                   20


<210>  692
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  692
agttgtccca atacctgctt                                                   20


<210>  693
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  693
ctgcttcgcg ggcacggctg                                                   20


<210>  694
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  694
tctggtgggc acgcagcagc                                                   20


<210>  695
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  695
cattccgttc tcagttttcc                                                   20


<210>  696
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  696
ggtacctgca ctgggctgac                                                   20


<210>  697
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  697
caagcggttc aagggcaaat                                                   20


<210>  698
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  698
tgatctcttg ggagaagaac                                                   20


<210>  699
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  699
ggtgacctac ccggactcag                                                   20


<210>  700
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  700
attccaatgg cttctgggtc                                                   20


<210>  701
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  701
acgatgagcg cagcgaaatt                                                   20


<210>  702
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  702
tgaggctggt gtcaatcctt                                                   20


<210>  703
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  703
gttttacaga gatcccttcc                                                   20


<210>  704
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  704
tgggccgggg ccttctgggc                                                   20


<210>  705
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  705
aagcagattt tctgccaggt                                                   20


<210>  706
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  706
agctgtgcga tgaagcaggc                                                   20


<210>  707
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  707
gatcactggc aattcagtgg                                                   20


<210>  708
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  708
gaggacgagg atctctaggg                                                   20


<210>  709
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  709
caccgtggaa ctggcccaac                                                   20


<210>  710
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  710
cttcacggtg tgggcgcagg                                                   20


<210>  711
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  711
cacgtttctg ctgatcgtgc                                                   20


<210>  712
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  712
ggcaggtctc attgaaggta                                                   20


<210>  713
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  713
acgacccgct ggacctcact                                                   20


<210>  714
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  714
acctgcgggt gcgtggctgc                                                   20


<210>  715
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  715
aattccggag tatcggccat                                                   20


<210>  716
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  716
ttctccggct tagaggtgac                                                   20


<210>  717
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  717
gggtcggaat gacccagata                                                   20


<210>  718
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  718
caagggctgt ggccggcaac                                                   20


<210>  719
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  719
tgtacacagt tgcaacacct                                                   20


<210>  720
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  720
ggtcccggat gtggtgagga                                                   20


<210>  721
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  721
ggtgggttac ggtcttcaaa                                                   20


<210>  722
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  722
atactgccgg gaagaagcaa                                                   20


<210>  723
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  723
gcagcagagc ttgcggcgcc                                                   20


<210>  724
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  724
ctcctggagg gtgctgttca                                                   20


<210>  725
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  725
ctgtacacag ttgcaacacc                                                   20


<210>  726
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  726
aggtgagcaa tctgtcagca                                                   20


<210>  727
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  727
ctgtcctctc cagctccagg                                                   20


<210>  728
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  728
tccatggggg ccatgaggtg                                                   20


<210>  729
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  729
catagcggat cagggagaag                                                   20


<210>  730
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  730
gtacagaggt attgttcttt                                                   20


<210>  731
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  731
aatacgggaa aaaggcgtgg                                                   20


<210>  732
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  732
gaagcatgtg tggagcgcct                                                   20


<210>  733
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  733
aagaacccgg gcacgctctt                                                   20


<210>  734
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  734
gaggctggtg tcaatccttc                                                   20


<210>  735
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  735
ccagcggtac agggtgacca                                                   20


<210>  736
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  736
ttggcacgaa tgaaaaggtt                                                   20


<210>  737
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  737
cagcccgggc ggcggcggcg                                                   20


<210>  738
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  738
acagcgaaat ctcgatggag                                                   20


<210>  739
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  739
ggtggcactg gaaggggaag                                                   20


<210>  740
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  740
ccgggagatg aaatgggatt                                                   20


<210>  741
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  741
gtctgatgca ctgtgtgcag                                                   20


<210>  742
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  742
gacgttgtag tccacgatgc                                                   20


<210>  743
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  743
ttgcaccatt ggccgcacac                                                   20


<210>  744
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  744
gccctgccgt acccgctgcc                                                   20


<210>  745
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  745
gcggttcaag ggcaaatggg                                                   20


<210>  746
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  746
tttacgcaat ggaacgcccg                                                   20


<210>  747
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  747
tgcacaacag cacccgcgac                                                   20


<210>  748
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  748
ggaccggctg tcacgggctc                                                   20


<210>  749
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  749
gcactgtgta ctcctgtgag                                                   20


<210>  750
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  750
gaagcagatt ttctgccagg                                                   20


<210>  751
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  751
ggtgacggtg agctctgcaa                                                   20


<210>  752
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  752
tgtgagatcc gccctttcca                                                   20


<210>  753
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  753
ccacagcaaa ccagtaaatc                                                   20


<210>  754
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  754
tactgagagc acagcgcagc                                                   20


<210>  755
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  755
aagctccgag gtcctggggg                                                   20


<210>  756
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  756
cgtgtgctgg cccatcactt                                                   20


<210>  757
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  757
taccgccgtg aatgcccgcc                                                   20


<210>  758
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  758
aacctccact gggccgacac                                                   20


<210>  759
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  759
ttaccgtgcg aagttaacgt                                                   20


<210>  760
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  760
tgtactttct ccagctccac                                                   20


<210>  761
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  761
cattcgcggt ggacgatgga                                                   20


<210>  762
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  762
ggaacaccgt ccattggcat                                                   20


<210>  763
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  763
cggatgctgc aggtgcacac                                                   20


<210>  764
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  764
ccgcactccg acctgagcca                                                   20


<210>  765
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  765
gcagaccgca agaataccat                                                   20


<210>  766
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  766
tcatctggaa cagtctacaa                                                   20


<210>  767
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  767
ctgtctcttc ctctagagtc                                                   20


<210>  768
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  768
gggccgatcc agcaggtaag                                                   20


<210>  769
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  769
gcggctggcc ttgggattga                                                   20


<210>  770
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  770
ccgttacccg gagggccaac                                                   20


<210>  771
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  771
gcaccgcagc ctggccagcc                                                   20


<210>  772
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  772
ttggccccgt tgagtctatc                                                   20


<210>  773
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  773
cgccggccac cagcactgcc                                                   20


<210>  774
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  774
actttaagtc cctgtttgtg                                                   20


<210>  775
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  775
tccggaggta ggacccggcg                                                   20


<210>  776
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  776
ttctgacagg cagcctgcac                                                   20


<210>  777
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  777
tgctctcgat tcgacttaaa                                                   20


<210>  778
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  778
gttcacgaca acgtgcacag                                                   20


<210>  779
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  779
tctcggcaac tgagcgaatt                                                   20


<210>  780
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  780
ccgaaggctt caatttccac                                                   20


<210>  781
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  781
ttgaacctgc aaccggttct                                                   20


<210>  782
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  782
gctgatcttc agcctccttt                                                   20


<210>  783
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  783
gcacccgcgt ctcctggtcg                                                   20


<210>  784
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  784
ggccaacgca ttaatacagt                                                   20


<210>  785
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  785
tgttctggtc ctgctttgag                                                   20


<210>  786
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  786
tcattgcaag ggaagtcctt                                                   20


<210>  787
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  787
tgcaaaccgg gccttctcac                                                   20


<210>  788
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  788
ccgggtcggg ccagtgccca                                                   20


<210>  789
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  789
caccacggag aagcataaag                                                   20


<210>  790
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  790
ccgcgcgccg cttgcgctcc                                                   20


<210>  791
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  791
agccgctacc ggtgtaatga                                                   20


<210>  792
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  792
tacgatgggg cgctcagggt                                                   20


<210>  793
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  793
tgcagaccgc aagaatacca                                                   20


<210>  794
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  794
ctacctcccg gaggccgcag                                                   20


<210>  795
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  795
ggcccgcccg gacggaaggc                                                   20


<210>  796
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  796
agcgacaggc ctggaaaacc                                                   20


<210>  797
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  797
tacatttaca ggtcccacga                                                   20


<210>  798
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  798
acaaagctcc gaggtcctgg                                                   20


<210>  799
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  799
aaaatacctc acgggagagg                                                   20


<210>  800
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  800
gggctggcag cgccaggtga                                                   20


<210>  801
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  801
aagatcactg gcaattcagt                                                   20


<210>  802
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  802
cttcacccgg gtcatggcgc                                                   20


<210>  803
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  803
tcttttcata tttaggggta                                                   20


<210>  804
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  804
ttccccgatg aggcagatgc                                                   20


<210>  805
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  805
cgccgagcgg aaacttttgt                                                   20


<210>  806
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  806
attgcacgtc cctgttcact                                                   20


<210>  807
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  807
gtactttctc cagctccact                                                   20


<210>  808
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  808
acagcgcacc ggcatcgagg                                                   20


<210>  809
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  809
catgactcgg gctgcaacca                                                   20


<210>  810
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  810
agtccacctg gggaggaagg                                                   20


<210>  811
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  811
tgaatggcag ccagggttgc                                                   20


<210>  812
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  812
ggcctgcagt aggtacgcgg                                                   20


<210>  813
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  813
ggcagaccac cagcagccta                                                   20


<210>  814
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  814
agacagcgca ccggcatcga                                                   20


<210>  815
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  815
tctgtccagg atgctcccaa                                                   20


<210>  816
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  816
catgcgccgc ctcgaggcct                                                   20


<210>  817
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  817
ccaggcttcc caaggttacc                                                   20


<210>  818
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  818
gcgccgcctc gaggccttgg                                                   20


<210>  819
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  819
caccttcccg tcggtgtatg                                                   20


<210>  820
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  820
tggtgcggtc ccgcgggcag                                                   20


<210>  821
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  821
cctgcgcggg tggtatcagt                                                   20


<210>  822
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  822
gcacacgtcc caacagctca                                                   20


<210>  823
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  823
gtcgaacgcc cgggtggagg                                                   20


<210>  824
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  824
ccctgccctc catcacccac                                                   20


<210>  825
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  825
gcagcccgga gcatgggctg                                                   20


<210>  826
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  826
gtcgccgccc gtggcccctg                                                   20


<210>  827
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  827
ccactgacag cagcgatgac                                                   20


<210>  828
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  828
tgcactcgcc gtgggtgcag                                                   20


<210>  829
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  829
cagtggccgt acagggagat                                                   20


<210>  830
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  830
gcgaatatct tctgcaatgg                                                   20


<210>  831
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  831
cgtcgcccag gagctgtggg                                                   20


<210>  832
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  832
gaacaccgtc cattggcatg                                                   20


<210>  833
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  833
tcacgttgca gccgaggttc                                                   20


<210>  834
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  834
gcacgtcgcc caggagctgt                                                   20


<210>  835
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  835
tcagtctggc aaagaagaag                                                   20


<210>  836
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  836
atccacccgg gccaccagcc                                                   20


<210>  837
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  837
gacagcgcac cggcatcgag                                                   20


<210>  838
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  838
agacttcgct ttccttggtc                                                   20


<210>  839
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  839
cacccgcaag tccctgccca                                                   20


<210>  840
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  840
cactactggg gtctcggtca                                                   20


<210>  841
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  841
cattcggaag aatgaacaga                                                   20


<210>  842
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  842
ctctgccttg gatcctaacc                                                   20


<210>  843
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  843
atcatctgga acagtctaca                                                   20


<210>  844
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  844
ttcacgacaa cgtgcacaga                                                   20


<210>  845
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  845
gggctgctgc gcagcggccg                                                   20


<210>  846
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  846
ggacaacgta gaaatactcc                                                   20


<210>  847
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  847
gaaatccaaa gtacctgtag                                                   20


<210>  848
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  848
tttaccgtgc gaagttaacg                                                   20


<210>  849
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  849
agccccctgt gtgctcaagg                                                   20


<210>  850
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  850
agacagcttc tcctgagaat                                                   20


<210>  851
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  851
ccagacgtcg cccaggccga                                                   20


<210>  852
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  852
aggaacaccg tccattggca                                                   20


<210>  853
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  853
ggtgccatag aaaaggagga                                                   20


<210>  854
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  854
ctcgccgtgg gtgcagaggc                                                   20


<210>  855
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  855
aattcaccgt aaagctggaa                                                   20


<210>  856
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  856
atgtatcaat tacagacact                                                   20


<210>  857
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  857
tgcacacata tgtgccaatg                                                   20


<210>  858
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  858
ctgtgagatc cgccctttcc                                                   20


<210>  859
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  859
cacggggcct tctacagtga                                                   20


<210>  860
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  860
agcacatcgc ccaagagctg                                                   20


<210>  861
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  861
ccggatgaag tagcacacga                                                   20


<210>  862
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  862
atacggaggt aatggcatgt                                                   20


<210>  863
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  863
ctttacccag agcttcgtcc                                                   20


<210>  864
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  864
cagaagttgc tcaaatcctg                                                   20


<210>  865
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  865
cgacgcagat ggtgatgccc                                                   20


<210>  866
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  866
gaggagccca atatgatcca                                                   20


<210>  867
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  867
cagtgaaagc acgggccagc                                                   20


<210>  868
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  868
cgagcggctg ccgagccggg                                                   20


<210>  869
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  869
tgcacttgca gcgccggttc                                                   20


<210>  870
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  870
atgttgtcag gggcaatgtg                                                   20


<210>  871
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  871
gtgcatgctg cacaactttg                                                   20


<210>  872
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  872
tactcttgca gtctgcatgc                                                   20


<210>  873
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  873
tccattcctg aatggaacag                                                   20


<210>  874
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  874
cctgcaccgg tacacgggcg                                                   20


<210>  875
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  875
ttccgatagg cagcctgcac                                                   20


<210>  876
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  876
ggatcggctt cactgtgctg                                                   20


<210>  877
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  877
ttccggagat ttatgttcta                                                   20


<210>  878
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  878
cgtataggcc acattgagat                                                   20


<210>  879
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  879
taggcacaca gctgacaaag                                                   20


<210>  880
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  880
actggttagg cggatctggt                                                   20


<210>  881
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  881
tgctgatgtt gctggaccag                                                   20


<210>  882
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  882
ggtgcgccgc ttggacatac                                                   20


<210>  883
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  883
tggagccggt agctaaagaa                                                   20


<210>  884
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  884
ggaggctcac gatgagtgcc                                                   20


<210>  885
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  885
acagaaggaa tagggacgag                                                   20


<210>  886
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  886
acgacaggag aggtcataac                                                   20


<210>  887
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  887
catgaacgcc tccatggtgt                                                   20


<210>  888
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  888
tttctcgata cggggagctg                                                   20


<210>  889
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  889
atcgatcgca ccctaaaagc                                                   20


<210>  890
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  890
agcagccacg atagcccaga                                                   20


<210>  891
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  891
tgctgacgaa ggtagcaggg                                                   20


<210>  892
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  892
actggaatcc agaaaccagt                                                   20


<210>  893
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  893
cacgaaaaag ccaagatgcg                                                   20


<210>  894
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  894
cgaggttgtc caggtgagcc                                                   20


<210>  895
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  895
cggctggaga gcatccacct                                                   20


<210>  896
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  896
gtccccgcag ggcattggca                                                   20


<210>  897
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  897
attcaccgta aagctggaaa                                                   20


<210>  898
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  898
ccccgctctc catcacccac                                                   20


<210>  899
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  899
ccacactggt taggcggatc                                                   20


<210>  900
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  900
cctgtgcgtc ccccaggggc                                                   20


<210>  901
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  901
tccacccggg ccaccagcca                                                   20


<210>  902
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  902
cagccgcccc tgctgggagt                                                   20


<210>  903
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  903
tgggtgccca ataagaccga                                                   20


<210>  904
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  904
gccgctggat cccgaaggtg                                                   20


<210>  905
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  905
gatgcgatga aggagatggg                                                   20


<210>  906
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  906
acacccgcaa gtccctgccc                                                   20


<210>  907
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  907
ggccgatcca gcaggtaagt                                                   20


<210>  908
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  908
tgccactgtc actgtagtct                                                   20


<210>  909
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  909
cgccacctgc gcgacttctg                                                   20


<210>  910
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  910
aagctcccgg acttttttct                                                   20


<210>  911
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  911
acggcgagtc gcattcgtgc                                                   20


<210>  912
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  912
ccttcgccac gcgcctggac                                                   20


<210>  913
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  913
acggaagaga aactcatgat                                                   20


<210>  914
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  914
tgtgcacgat gttggaggct                                                   20


<210>  915
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  915
gtccgagcta cagcaagatc                                                   20


<210>  916
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  916
aaccggctat tgttacccag                                                   20


<210>  917
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  917
gcaggagccc aacgtgacgg                                                   20


<210>  918
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  918
gtgcactgag ggccttgggg                                                   20


<210>  919
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  919
tccccgtgct gctggagttg                                                   20


<210>  920
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  920
caccatcccg agtgcagacc                                                   20


<210>  921
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  921
gcacggcacc gtcaccaact                                                   20


<210>  922
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  922
gaccgcgtcc agtttcagag                                                   20


<210>  923
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  923
ccgcactgcc atcattgccc                                                   20


<210>  924
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  924
ccaacaatgc agagtgaggt                                                   20


<210>  925
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  925
ggctgatcac ctcacgctcc                                                   20


<210>  926
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  926
cagccttgcc cagttttccc                                                   20


<210>  927
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  927
cgatctgagt catcttctcc                                                   20


<210>  928
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  928
agacagaggc agaaatcgtg                                                   20


<210>  929
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  929
cgtgcgagtt ggcagcggcg                                                   20


<210>  930
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  930
cgttcggctt gtggtgtaat                                                   20


<210>  931
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  931
ggtgctccca ggtggggccc                                                   20


<210>  932
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  932
ttcggtaacc tacagctcac                                                   20


<210>  933
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  933
accgaaggct ggtggccaca                                                   20


<210>  934
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  934
ccgaagtcga aaccagcgct                                                   20


<210>  935
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  935
agcacatctc acggccgcgc                                                   20


<210>  936
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  936
ttcctactcg gacaaagttc                                                   20


<210>  937
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  937
cagcacaaca ctgctgctgt                                                   20


<210>  938
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  938
gacgctggcc agctacgggc                                                   20


<210>  939
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  939
catgctgcag aagactttga                                                   20


<210>  940
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  940
cgaaacgtgt atctcctccc                                                   20


<210>  941
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  941
ttagtgacac ttgtgggcca                                                   20


<210>  942
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  942
ttcctcgccc gtcaggagga                                                   20


<210>  943
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  943
tcccgctggc cctcgcggcc                                                   20


<210>  944
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  944
gccgaggagg ctctcttctg                                                   20


<210>  945
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  945
ctcccggcgc tacggaagtg                                                   20


<210>  946
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  946
ctgccgccaa aactgaaggc                                                   20


<210>  947
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  947
gccaacgcat taatacagtg                                                   20


<210>  948
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  948
aaggccagaa tagaaggaat                                                   20


<210>  949
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  949
ctgtccagga tgctcccaag                                                   20


<210>  950
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  950
ctgccgcgcg tggcccgagg                                                   20


<210>  951
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  951
gtacacggcg ggcacgttga                                                   20


<210>  952
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  952
acccaaacga atatcttgtg                                                   20


<210>  953
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  953
cctcgtaggt gctggtgtcc                                                   20


<210>  954
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  954
gctgccgcgc gtggcccgag                                                   20


<210>  955
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  955
agtacacatc tcctaacttc                                                   20


<210>  956
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  956
agtccacacg catatgtgta                                                   20


<210>  957
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  957
tgctgacggc tctggtcagc                                                   20


<210>  958
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  958
tgacatgggc attctgggaa                                                   20


<210>  959
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  959
gtttagttcg atttataaga                                                   20


<210>  960
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  960
gagaaggccg tgtaggtaag                                                   20


<210>  961
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  961
gaacccaccg ggtgacgatg                                                   20


<210>  962
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  962
gccgtcgtcg acgacgagcg                                                   20


<210>  963
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  963
accgtggaac tggcccaact                                                   20


<210>  964
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  964
ctttaagtcc ctgtttgtgc                                                   20


<210>  965
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  965
gcgtatggtc tctttgtttc                                                   20


<210>  966
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  966
gagtcctttg cccttttgag                                                   20


<210>  967
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  967
gtactgcctg tctggggaca                                                   20


<210>  968
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  968
gtggagccgg tagctaaaga                                                   20


<210>  969
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  969
cgcctgcacc tcttcatgcc                                                   20


<210>  970
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  970
tgagccttcc gtgttttcac                                                   20


<210>  971
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  971
ctcattgttc ccgcctttcc                                                   20


<210>  972
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  972
ctgccgtggg tgcagaggct                                                   20


<210>  973
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  973
gttggcctcg ggattgaggg                                                   20


<210>  974
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  974
cccagcacag ttggcaaaca                                                   20


<210>  975
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  975
ccatcgactg tgtgcatttt                                                   20


<210>  976
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  976
gcgtggctgc tcggtctcca                                                   20


<210>  977
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  977
tagcacattt gcaacaagct                                                   20


<210>  978
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  978
ttggcggctg ctggatccac                                                   20


<210>  979
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  979
gcagatgact cgggcaaagg                                                   20


<210>  980
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  980
ccgggcctcg tcgcccacat                                                   20


<210>  981
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  981
gatgctgccc gtgttgagct                                                   20


<210>  982
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  982
cccatacgcc tgccttccaa                                                   20


<210>  983
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  983
cggcgtggaa gagagcatca                                                   20


<210>  984
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  984
cacgcaaagg aagggctact                                                   20


<210>  985
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  985
gccggagctt gagagagacg                                                   20


<210>  986
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  986
ccgtgtggtc tcgcgatcag                                                   20


<210>  987
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  987
tgccgcggtg gcgctgtcag                                                   20


<210>  988
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  988
cgttgttttg ggacaccact                                                   20


<210>  989
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  989
attcgcggtg gacgatggaa                                                   20


<210>  990
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  990
ccggagatgg caatcgaagc                                                   20


<210>  991
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  991
cgaatccgca ctcatcatcc                                                   20


<210>  992
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  992
aaactgccgt ttagattacc                                                   20


<210>  993
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  993
gcgacgcgct cgtactcaga                                                   20


<210>  994
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  994
ggtgtcgaac gcccgggtgg                                                   20


<210>  995
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  995
gacgctggcc acggccacga                                                   20


<210>  996
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  996
gcgctctcgg caaagaacgc                                                   20


<210>  997
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  997
gtgcggcatt tgtcctgctc                                                   20


<210>  998
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  998
gccctcgttg ctctctgagt                                                   20


<210>  999
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  999
gcagccgccc ctgctgggag                                                   20


<210>  1000
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1000
ggccgcgcat gtgttcagaa                                                   20


<210>  1001
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1001
aggtccaagg cccaggctgg                                                   20


<210>  1002
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1002
ttatccgctg ctcaagggac                                                   20


<210>  1003
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1003
atgtgttcgc gcagggagct                                                   20


<210>  1004
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1004
agcataccgg cggatggtcc                                                   20


<210>  1005
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1005
tgtgttcgcg cagggagctc                                                   20


<210>  1006
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1006
cgcctccatg gtgtgggcgc                                                   20


<210>  1007
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1007
gcacaccttg aggtcacggc                                                   20


<210>  1008
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1008
ccgaatgtcc tggatttcca                                                   20


<210>  1009
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1009
actctttggg atcgacttcc                                                   20


<210>  1010
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1010
ggaagcggcg tgctgtgctg                                                   20


<210>  1011
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1011
cgtgccgcta gacacggacg                                                   20


<210>  1012
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1012
aatgcgactg ctgacaaaga                                                   20


<210>  1013
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1013
cctgcgggtg cgtggctgca                                                   20


<210>  1014
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1014
tctacccgga ccctgcatac                                                   20


<210>  1015
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1015
agagattctg gggcaggcgt                                                   20


<210>  1016
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1016
gaaaaccaat tgatgaggta                                                   20


<210>  1017
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1017
tgcctcatca agctacccaa                                                   20


<210>  1018
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1018
gtacctcaca aaaacagtag                                                   20


<210>  1019
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1019
gatgaacagc cactggggcc                                                   20


<210>  1020
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1020
gtgagcggcc tctttatatg                                                   20


<210>  1021
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1021
ccctgcgcgg gtggtatcag                                                   20


<210>  1022
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1022
gctcatgcct gagctggccc                                                   20


<210>  1023
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1023
aaggtacaca tggtaggata                                                   20


<210>  1024
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1024
ggtccaaggc ccaggctgga                                                   20


<210>  1025
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1025
gtggccgtac agggagattg                                                   20


<210>  1026
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1026
ggcctgatgg agccacccca                                                   20


<210>  1027
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1027
agagaccgcc aacatgtcac                                                   20


<210>  1028
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1028
gtgagatccg ccctttccag                                                   20


<210>  1029
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1029
tcgaccggca gacaggccct                                                   20


<210>  1030
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1030
caacgtgccg gtctgtgtgc                                                   20


<210>  1031
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1031
ctgacaggcg ttgtcggaga                                                   20


<210>  1032
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1032
aaaacctacg ccatgggtgg                                                   20


<210>  1033
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1033
gccaacagac tgatttcctg                                                   20


<210>  1034
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1034
aaccccggct gttgttacca                                                   20


<210>  1035
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1035
ggctgtcctc tccagctcca                                                   20


<210>  1036
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1036
gcaggacccg gaagccatcc                                                   20


<210>  1037
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1037
ataacgaatg ccccatcgat                                                   20


<210>  1038
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1038
aaattcgcaa gtatgtctta                                                   20


<210>  1039
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1039
tcgtggtgcc gctactgggc                                                   20


<210>  1040
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1040
tggcatcgtt gatgacattc                                                   20


<210>  1041
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1041
ttgatacaag cccaggaaat                                                   20


<210>  1042
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1042
aggctgccac gcgggagacc                                                   20


<210>  1043
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1043
agagcccggc caagtgctgc                                                   20


<210>  1044
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1044
gaagaccgcc gaggtgggcg                                                   20


<210>  1045
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1045
gagggcccgg agcccctgag                                                   20


<210>  1046
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1046
catacaaaga ggccactcac                                                   20


<210>  1047
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1047
gaggcacagg gcatgggtga                                                   20


<210>  1048
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1048
tcagtcatgc tgtcacaact                                                   20


<210>  1049
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1049
ggcaccgtgc gagttggcag                                                   20


<210>  1050
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1050
gcataccggc ggatggtcca                                                   20


<210>  1051
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1051
aagaggatcc cggatgctgc                                                   20


<210>  1052
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1052
cttggcttcc tgggtgagaa                                                   20


<210>  1053
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1053
catgacgcag gcgctgctgg                                                   20


<210>  1054
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1054
cacacggctg agacgttcca                                                   20


<210>  1055
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1055
taaggacccg cagcaccggc                                                   20


<210>  1056
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1056
gcggctctgg aaccagacct                                                   20


<210>  1057
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1057
ccgatccgca cctggtgcgt                                                   20


<210>  1058
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1058
gagctgcccg ccgaagaagc                                                   20


<210>  1059
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1059
ccacacctgt gacggctctg                                                   20


<210>  1060
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1060
gaccctcatc ggcaacagca                                                   20


<210>  1061
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1061
ccactgcgct gcccgcgcag                                                   20


<210>  1062
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1062
cgcccgtggc ccggctgctg                                                   20


<210>  1063
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1063
gatgctggcg cccggctggc                                                   20


<210>  1064
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1064
ggaccatgcc tggacgccca                                                   20


<210>  1065
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1065
tgtcaagaga gcgaatgtca                                                   20


<210>  1066
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1066
ctggccggac cgaggaacca                                                   20


<210>  1067
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1067
cgctctcggc aaagaacgct                                                   20


<210>  1068
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1068
tagatttcca tggggaagta                                                   20


<210>  1069
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1069
tgcgccgcct cgaggccttg                                                   20


<210>  1070
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1070
gcactccgca gcagtgggcc                                                   20


<210>  1071
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1071
ggcacagtgg aagatctatg                                                   20


<210>  1072
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1072
ctgccggatc cccctgctga                                                   20


<210>  1073
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1073
gtacactggg tgatcctgca                                                   20


<210>  1074
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1074
attcggaaga atgaacagaa                                                   20


<210>  1075
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1075
ggggtctcga taataaaatt                                                   20


<210>  1076
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1076
acatcgactt taaatgactt                                                   20


<210>  1077
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1077
gccacttcca gaactgcccg                                                   20


<210>  1078
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1078
ccaacctgac ccgcttcttc                                                   20


<210>  1079
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1079
cctgtaccgc acgctgtact                                                   20


<210>  1080
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1080
cgtgccggcc tcgcgcatgg                                                   20


<210>  1081
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1081
tcactgagcc agggaactat                                                   20


<210>  1082
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1082
cgcgcccgga ggaggaaatc                                                   20


<210>  1083
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1083
gccgctcacg cagcttgcgc                                                   20


<210>  1084
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1084
gcgcagttcc tcccgctcgc                                                   20


<210>  1085
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1085
cctccttcac ctgcttgagg                                                   20


<210>  1086
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1086
tgaacctgca accggttcta                                                   20


<210>  1087
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1087
gcgcctggcc agccctccac                                                   20


<210>  1088
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1088
catgccgcta gaggaggaaa                                                   20


<210>  1089
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1089
acgcccgtgg tatgttatgc                                                   20


<210>  1090
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1090
tatccgctgc tcaagggact                                                   20


<210>  1091
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1091
gcgccgagcg gggttcatgt                                                   20


<210>  1092
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1092
tggccacgac caagcccgac                                                   20


<210>  1093
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1093
gctcttcccg acactgcagc                                                   20


<210>  1094
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1094
tgaagcagca cacgatggcc                                                   20


<210>  1095
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1095
tgcagcagcc gcccttctgc                                                   20


<210>  1096
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1096
gtgcagccgg gctcgctgct                                                   20


<210>  1097
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1097
ctcacctcca acatcactgc                                                   20


<210>  1098
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1098
aatacgtgct gaaaatgata                                                   20


<210>  1099
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1099
agaaatacga tggggcgctc                                                   20


<210>  1100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1100
gcgacaggcc tggaaaacca                                                   20


<210>  1101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1101
gctctcgcga gccgccttgg                                                   20


<210>  1102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1102
cccaccgctc ctgtgacagc                                                   20


<210>  1103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1103
gacacgaagc acacacaata                                                   20


<210>  1104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1104
cagccatggc caggccccag                                                   20


<210>  1105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1105
cttcctgctg cggtccccaa                                                   20


<210>  1106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1106
ttccggagta tcggccatgg                                                   20


<210>  1107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1107
tccatcgtgg cccaggaagg                                                   20


<210>  1108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1108
ccatgacgca ggcgctgctg                                                   20


<210>  1109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1109
actcacgctg gcggtcatgc                                                   20


<210>  1110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1110
ctgcaccggt acacgggcga                                                   20


<210>  1111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1111
acagcggcag ctgccagtga                                                   20


<210>  1112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1112
ccaagtttca ggatgcttct                                                   20


<210>  1113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1113
gggccctggc ccacgtacgg                                                   20


<210>  1114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1114
gcagcccctc ggtctgcaac                                                   20


<210>  1115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1115
aaactccgtc cccatggccg                                                   20


<210>  1116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1116
aggcgtcgac cagcgagtac                                                   20


<210>  1117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1117
ggagacggcc tccatgaagg                                                   20


<210>  1118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1118
gcccgccttg tgtccaagaa                                                   20


<210>  1119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1119
actctgctgt tcggaactac                                                   20


<210>  1120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1120
cagtgccgcc tgcattcgcg                                                   20


<210>  1121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1121
ggacccgcct gtggatgcag                                                   20


<210>  1122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1122
taagccctgc cagccaagct                                                   20


<210>  1123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1123
tgcacaggga attccaagaa                                                   20


<210>  1124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1124
cctgccggcc aactccaaag                                                   20


<210>  1125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1125
agaacatcac tgggggctac                                                   20


<210>  1126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1126
caggtggggc ccgggcatcc                                                   20


<210>  1127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1127
ggtagattcc aatggcttct                                                   20


<210>  1128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1128
gaccactgcg ctgcccgcgc                                                   20


<210>  1129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1129
cctgggctgc tgcgccagca                                                   20


<210>  1130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1130
tgcacctgcc gtgggtgcag                                                   20


<210>  1131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1131
acgtggttgt ggtcgttctg                                                   20


<210>  1132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1132
gtaccggaca gacgtgagcg                                                   20


<210>  1133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1133
cactggggac cgcagcaaga                                                   20


<210>  1134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1134
cagggcgtca cggtcggtat                                                   20


<210>  1135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1135
tcatccgttt gcctgctaag                                                   20


<210>  1136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1136
cttggcctcg agcctcagcg                                                   20


<210>  1137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1137
cgccgccatt accccggcca                                                   20


<210>  1138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1138
cgagtattcg cgctccggcg                                                   20


<210>  1139
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1139
tgccacgagc cttcacctta                                                   20


<210>  1140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1140
tgctgcactg ccaattgctg                                                   20


<210>  1141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1141
gccctccgtg tgctcaaggg                                                   20


<210>  1142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1142
ggcccacagg tgcagttcca                                                   20


<210>  1143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1143
gataagtcta ccatcctgcg                                                   20


<210>  1144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1144
gagaccacaa gaggcagagc                                                   20


<210>  1145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1145
aaccagagta atagcgggtc                                                   20


<210>  1146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1146
ttgctctcga ttcgacttaa                                                   20


<210>  1147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1147
tgcaaccttg gcctcgaggg                                                   20


<210>  1148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1148
gacatcgact ttaaatgact                                                   20


<210>  1149
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1149
aattcacgca ttcagactcg                                                   20


<210>  1150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1150
tgacaggcag cctgcactgg                                                   20


<210>  1151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1151
cacacacacc acgccctctt                                                   20


<210>  1152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1152
ggcgcttccg gggggcctca                                                   20


<210>  1153
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1153
aagcgctcct tcttcgatgt                                                   20


<210>  1154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1154
tgaccgtact gaaaaacaaa                                                   20


<210>  1155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1155
ggattttatc cgctgctcaa                                                   20


<210>  1156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1156
ggacctgccc aacgtgaaga                                                   20


<210>  1157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1157
gcggcaacgg tgtagcggcg                                                   20


<210>  1158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1158
gttcggcttg tggtgtaatt                                                   20


<210>  1159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1159
gacacacagc gtgacctgag                                                   20


<210>  1160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1160
gaggcgacag aaggagctca                                                   20


<210>  1161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1161
ctgctcagag gcagggtgta                                                   20


<210>  1162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1162
gggaacccgc tgctcaccac                                                   20


<210>  1163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1163
agccgctgga tcccgaaggt                                                   20


<210>  1164
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1164
gagaagacga cccaggtgag                                                   20


<210>  1165
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1165
tactcctgtc agctgattga                                                   20


<210>  1166
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1166
ccacgggcgg caggcgcccg                                                   20


<210>  1167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1167
ccggacagct tccccaaagg                                                   20


<210>  1168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1168
cccgctggac ctcactcggc                                                   20


<210>  1169
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1169
aggttacaac atcatcagga                                                   20


<210>  1170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1170
ggtgcacaca gaaccattac                                                   20


<210>  1171
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1171
ccgtgctttc tggaacgagt                                                   20


<210>  1172
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1172
agaggttcct tgagtccttt                                                   20


<210>  1173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1173
ccagtgccgc ctgcattcgc                                                   20


<210>  1174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1174
gcggctgttt tgctatgcag                                                   20


<210>  1175
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1175
ccaagtggct ggccaacttc                                                   20


<210>  1176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1176
ggaaggggac cggtcctggg                                                   20


<210>  1177
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1177
caagaacagc attgcataca                                                   20


<210>  1178
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1178
gaaggagcca gaggaaaaac                                                   20


<210>  1179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1179
cacgttgacc acgatgagga                                                   20


<210>  1180
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1180
atcagtcatg ctgtcacaac                                                   20


<210>  1181
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1181
aacggtgtag cggcgggggc                                                   20


<210>  1182
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1182
gcccatggac aggttcgagg                                                   20


<210>  1183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1183
gcagcacaac actgctgctg                                                   20


<210>  1184
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1184
gccgctactg ctcagcctgc                                                   20


<210>  1185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1185
ctggagtacc cgcatagcca                                                   20


<210>  1186
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1186
aacgctgtcc accgtggagc                                                   20


<210>  1187
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1187
gcgggtagag ggtctgcagc                                                   20


<210>  1188
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1188
ttgctgatgt tgctggacca                                                   20


<210>  1189
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1189
cggaagatct atgaggaatg                                                   20


<210>  1190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1190
gcttgtgaca tgggcattct                                                   20


<210>  1191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1191
tctcaatatc caggagttgt                                                   20


<210>  1192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1192
agtaggcctt gccaaagcca                                                   20


<210>  1193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1193
cccggaggcc gcagaggagc                                                   20


<210>  1194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1194
caggtggtga ccccggtgcc                                                   20


<210>  1195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1195
tccttttata tttaggggta                                                   20


<210>  1196
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1196
cccaactgag aaccaagaag                                                   20


<210>  1197
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1197
gccgctagac acggacgcgg                                                   20


<210>  1198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1198
cctgtttgtg cgggagccct                                                   20


<210>  1199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1199
ctggacgtcc acccgcttgg                                                   20


<210>  1200
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1200
gtacagcccg agagagagcc                                                   20


<210>  1201
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1201
cgggcttctt ctccctactc                                                   20


<210>  1202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1202
acccggatat caagaacttt                                                   20


<210>  1203
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1203
gagctggtgc ctggggctcc                                                   20


<210>  1204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1204
gcccaacgtg aagatggccc                                                   20


<210>  1205
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1205
ttttacagag atcccttccg                                                   20


<210>  1206
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1206
caccgcgagg ctaggaggat                                                   20


<210>  1207
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1207
aaaacgttta cagcttccag                                                   20


<210>  1208
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1208
ctccttcacc tgcttgaggt                                                   20


<210>  1209
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1209
cggacagctt ccccaaaggt                                                   20


<210>  1210
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1210
ccacatgcac tcgcgtgtgg                                                   20


<210>  1211
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1211
cgagtcagat ctgcaatctg                                                   20


<210>  1212
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1212
ttccatgggg gccatgaggt                                                   20


<210>  1213
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1213
tacctggtcc ttctcctcag                                                   20


<210>  1214
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1214
cgatggagag gcgtgagcgc                                                   20


<210>  1215
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1215
acggtgacct caaggcttct                                                   20


<210>  1216
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1216
ccgagtcaga tctgcaatct                                                   20


<210>  1217
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1217
cgttgcaatc ccttaagcat                                                   20


<210>  1218
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1218
cggagggcat ccgcatctgc                                                   20


<210>  1219
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1219
gatcctgtca tcatcatcaa                                                   20


<210>  1220
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1220
ctcatactgt ggaatgcctg                                                   20


<210>  1221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1221
ggaagcaaac cgcaattctt                                                   20


<210>  1222
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1222
aggagcagcc acgctcagtg                                                   20


<210>  1223
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1223
cggaggggat ggcgcctagg                                                   20


<210>  1224
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1224
ccggggctgc ccctggacgc                                                   20


<210>  1225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1225
atgttcgaca gcggaaaccc                                                   20


<210>  1226
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1226
cgcgagaaat ctcgaaccag                                                   20


<210>  1227
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1227
gcccaattcc tttagcaatg                                                   20


<210>  1228
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1228
cccgggtctg ggacaggacc                                                   20


<210>  1229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1229
gccctgtgcc ctgcgagcca                                                   20


<210>  1230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1230
gaccggagga gaactactgc                                                   20


<210>  1231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1231
tacagtgttc ctaaaaggca                                                   20


<210>  1232
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1232
ctcacgcagc ttgcgcaggt                                                   20


<210>  1233
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1233
agcccgaccc acatcaaggc                                                   20


<210>  1234
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1234
ccctgcctcg cgcattcggc                                                   20


<210>  1235
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1235
taggcacgtc agacccgaac                                                   20


<210>  1236
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1236
tttcagcctt agaaatacac                                                   20


<210>  1237
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1237
cgtgacgaag gctatgaaag                                                   20


<210>  1238
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1238
ccagcatcat cccccaggtg                                                   20


<210>  1239
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1239
tatcactctt gaggtctctg                                                   20


<210>  1240
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1240
ccctgaggca gacgaggcac                                                   20


<210>  1241
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1241
aagccgctgg atcccgaagg                                                   20


<210>  1242
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1242
aaaccgcaag tttggctttt                                                   20


<210>  1243
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1243
cgcactgcca tcattgccca                                                   20


<210>  1244
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1244
ccaggcagga ggctcgggtg                                                   20


<210>  1245
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1245
gtggaggaca cgcaaaggaa                                                   20


<210>  1246
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1246
ggcgtagtcc ttcccagaga                                                   20


<210>  1247
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1247
ctacctgtcc ggggtgctgc                                                   20


<210>  1248
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1248
gcgccacatg cactcgcgtg                                                   20


<210>  1249
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1249
ggaggcacag ggcatgggtg                                                   20


<210>  1250
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1250
cttcccggca ggacgcagca                                                   20


<210>  1251
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1251
gcctctcttg gacacaaagc                                                   20


<210>  1252
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1252
ggtagcggcc ggtgccgtct                                                   20


<210>  1253
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1253
agctccgttt cgtgatgttt                                                   20


<210>  1254
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1254
cggcaacggt gtagcggcgg                                                   20


<210>  1255
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1255
ctctggcaac cgctgcctga                                                   20


<210>  1256
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1256
cattcgcaca gatgagtaca                                                   20


<210>  1257
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1257
agcggcgcct caagcagcag                                                   20


<210>  1258
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1258
acctccactg ggccgacact                                                   20


<210>  1259
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1259
caatcaatca cttcagagaa                                                   20


<210>  1260
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1260
ggccgacccg ctggaggcgc                                                   20


<210>  1261
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1261
gagcccgacc cacatcaagg                                                   20


<210>  1262
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1262
attcgcacag atgagtacat                                                   20


<210>  1263
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1263
ctgctctccg ccgcctgctg                                                   20


<210>  1264
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1264
atgccggagt tcagtttgtt                                                   20


<210>  1265
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1265
ccaccgcctg ctggtgaccc                                                   20


<210>  1266
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1266
ccggagcttc cggccctctg                                                   20


<210>  1267
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1267
acagtgttcc taaaaggcac                                                   20


<210>  1268
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1268
acaacccgga gcgctatggc                                                   20


<210>  1269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1269
cacaactctg ggggaaacca                                                   20


<210>  1270
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1270
agccgattga gactagtgag                                                   20


<210>  1271
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1271
cggcacccgt acctccgggg                                                   20


<210>  1272
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1272
gcagaagaac accctggcgg                                                   20


<210>  1273
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1273
aaaccgcccg gggcaggtgc                                                   20


<210>  1274
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1274
gcgctcggcc gcgcgccttg                                                   20


<210>  1275
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1275
cagtgcccgg ccatgggctg                                                   20


<210>  1276
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1276
ctcggcaaag aacgctggga                                                   20


<210>  1277
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1277
cctcgatgaa gcactcgttg                                                   20


<210>  1278
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1278
taacagcggg tcaggcaccg                                                   20


<210>  1279
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1279
gttttctacc ttcttttccc                                                   20


<210>  1280
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1280
ccgccatccg cgcgagtacc                                                   20


<210>  1281
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1281
gtcgagctgc aaggggatag                                                   20


<210>  1282
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1282
cggagcttcc ggccctctgg                                                   20


<210>  1283
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1283
gagtctgggc tctgcaaaca                                                   20


<210>  1284
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1284
tccatagcgg cagacattaa                                                   20


<210>  1285
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1285
gggcctgatg gagccacccc                                                   20


<210>  1286
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1286
tttctgagca gtggctccga                                                   20


<210>  1287
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1287
gcggaggccc cggagaggtg                                                   20


<210>  1288
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1288
tgttgttgtc gagctgcaag                                                   20


<210>  1289
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1289
ccggtacacg ggcgagggca                                                   20


<210>  1290
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1290
gactacaacc cggagcgcta                                                   20


<210>  1291
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1291
ttcccgctgg gctactcgga                                                   20


<210>  1292
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1292
atacgggaaa aaggcgtggt                                                   20


<210>  1293
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1293
gcagggcgtc acggtcggta                                                   20


<210>  1294
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1294
gaagctccgc cacactgtga                                                   20


<210>  1295
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1295
aaggccgccc ggggtaaggt                                                   20


<210>  1296
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1296
ccacacggct gagacgttcc                                                   20


<210>  1297
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1297
gcacagggca tgggtgaggg                                                   20


<210>  1298
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1298
tgcctctctt ggacacaaag                                                   20


<210>  1299
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1299
gagccggaca ctgaaacctt                                                   20


<210>  1300
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1300
ccgttgcaat cccttaagca                                                   20


<210>  1301
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1301
cctcgggcgc acccacgaga                                                   20


<210>  1302
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1302
cccggacttc gagaacgaga                                                   20


<210>  1303
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1303
ccacccgagg caggggcggc                                                   20


<210>  1304
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1304
ccggaggtag gacccggcgg                                                   20


<210>  1305
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1305
agctactggg taagggggac                                                   20


<210>  1306
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1306
aagaaaacct acgccatggg                                                   20


<210>  1307
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1307
cgacagggta cttcagggtc                                                   20


<210>  1308
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1308
cctctgtcag ggagccctcc                                                   20


<210>  1309
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1309
ctctacccgg accctgcata                                                   20


<210>  1310
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1310
ggctcacgat gagtgcctgg                                                   20


<210>  1311
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1311
aacccgctgc tcaccaccgg                                                   20


<210>  1312
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1312
tcaaacgtgc agatgccaat                                                   20


<210>  1313
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1313
gaagccgccg aagtccctgt                                                   20


<210>  1314
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1314
gtccagtcaa aggagcaaag                                                   20


<210>  1315
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1315
caagcgctcc ttcttcgatg                                                   20


<210>  1316
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1316
ggccgccgcc caacgccatc                                                   20


<210>  1317
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1317
ggcatgcatc cgctcatcac                                                   20


<210>  1318
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1318
tgcggcattt gtcctgctcc                                                   20


<210>  1319
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1319
ctgatctcag gtacagtttc                                                   20


<210>  1320
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1320
acgtccagtc aaaggagcaa                                                   20


<210>  1321
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1321
gttgccggcg cgcctcgcag                                                   20


<210>  1322
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1322
gctccggagg taggacccgg                                                   20


<210>  1323
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1323
ctccggaggt aggacccggc                                                   20


<210>  1324
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1324
tccgggggcc cgcccagatc                                                   20


<210>  1325
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1325
gagtaggcct tgccaaagcc                                                   20


<210>  1326
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1326
gcgcggcacc cgtacctccg                                                   20


<210>  1327
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1327
cgataggcag cctgcactgg                                                   20


<210>  1328
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1328
gtgggccgtg ctgtgggagt                                                   20


<210>  1329
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1329
ccgctagaca cggacgcggc                                                   20


<210>  1330
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1330
atggaggtga ctgggcctac                                                   20


<210>  1331
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1331
gcgccattgg gccgtggtcc                                                   20


<210>  1332
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1332
tgaccacctg gcttcctact                                                   20


<210>  1333
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1333
atagatccat ctggtcctgc                                                   20


<210>  1334
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1334
ttcactctct taacattcag                                                   20


<210>  1335
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1335
ctgcgacaac aacggttttc                                                   20


<210>  1336
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1336
cacctactcc acgaagcgcc                                                   20


<210>  1337
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1337
ggggcaaagg ctgtgctcaa                                                   20


<210>  1338
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1338
gccggactca ccaggaccag                                                   20


<210>  1339
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1339
cgctgtcagg tgcaagctct                                                   20


<210>  1340
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1340
gacctatcct aaggtacgtg                                                   20


<210>  1341
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1341
gagttcaagt ccccaccaca                                                   20


<210>  1342
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1342
ctacaggcgg caggcgcccg                                                   20


<210>  1343
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1343
ctggctagat atgagaagca                                                   20


<210>  1344
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1344
gtgtcagggg cggcccacga                                                   20


<210>  1345
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1345
tgtagctact gctgctgctg                                                   20


<210>  1346
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1346
cctgtttcat cttgctggca                                                   20


<210>  1347
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1347
cttgagattg ctgggatcac                                                   20


<210>  1348
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1348
gcacctacgt ctcctggtcg                                                   20


<210>  1349
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1349
aagggatccg cctggtcctc                                                   20


<210>  1350
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1350
gcacatatcc caacagctca                                                   20


<210>  1351
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1351
agatgctgag cccgaagcag                                                   20


<210>  1352
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1352
gacagctccc acgcctacat                                                   20


<210>  1353
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1353
accagccccc ctgggcctcc                                                   20


<210>  1354
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1354
tgttgctact gctgctgggc                                                   20


<210>  1355
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1355
tcacgactgg gatgaaccac                                                   20


<210>  1356
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1356
cggcgcccta tagctgcgcg                                                   20


<210>  1357
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1357
cctgccaagt gaggtccagc                                                   20


<210>  1358
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1358
actgatgctc ctggcagccc                                                   20


<210>  1359
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1359
agacttcggg ccaggcttga                                                   20


<210>  1360
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1360
cctgaggcgc cccacgatgg                                                   20


<210>  1361
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1361
gaagctgagc gacgagggca                                                   20


<210>  1362
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1362
ctgagatctg gtttgcaact                                                   20


<210>  1363
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1363
tgtgcaaaag ggccaggcag                                                   20


<210>  1364
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1364
actcaggggt cggcaggcag                                                   20


<210>  1365
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1365
gtcgctaggc aaagtggtca                                                   20


<210>  1366
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1366
ctcccattct cccgccatgt                                                   20


<210>  1367
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1367
gtctcagtgc aggatgaggt                                                   20


<210>  1368
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1368
ctacaagctg ccagacgggc                                                   20


<210>  1369
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1369
tggcccagcg gttcagccac                                                   20


<210>  1370
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1370
cttctatcca ggggcgatga                                                   20


<210>  1371
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1371
caattaatcc caaggaacga                                                   20


<210>  1372
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1372
ttagttcagc caccttctag                                                   20


<210>  1373
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1373
gctgcccacc tggctgtgga                                                   20


<210>  1374
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1374
ccacacccgg ccaatgttgt                                                   20


<210>  1375
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1375
ccttcacagc tcctgaaagg                                                   20


<210>  1376
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1376
tctttcaggc agcctctttg                                                   20


<210>  1377
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1377
tttgatctcc ctggtcctgc                                                   20


<210>  1378
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1378
tcttcatcca gtgctggtcc                                                   20


<210>  1379
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1379
gcgggaactc tcggggcaga                                                   20


<210>  1380
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1380
ggtctacgtt cagctggccc                                                   20


<210>  1381
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1381
ccctagtcct ccaggcttcc                                                   20


<210>  1382
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1382
agagctaggg gggcggtggc                                                   20


<210>  1383
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1383
ccagctaccc cagctactgg                                                   20


<210>  1384
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1384
cccgtcctac tggggcatca                                                   20


<210>  1385
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1385
tcagggactc tgtggggatg                                                   20


<210>  1386
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1386
ccgggacttt ccagggcccc                                                   20


<210>  1387
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1387
ggatgagccc ccaggtcctg                                                   20


<210>  1388
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1388
cgagtagggg agccaccagt                                                   20


<210>  1389
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1389
ctattgggac ccagccaaac                                                   20


<210>  1390
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1390
gagtcagtca tcgctaggga                                                   20


<210>  1391
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1391
tccccagaaa ctggaatctg                                                   20


<210>  1392
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1392
catgtatctc gacatccacg                                                   20


<210>  1393
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1393
cgctgacttt gtcttctact                                                   20


<210>  1394
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1394
acgtgatccc cctggacccc                                                   20


<210>  1395
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1395
cgccatatac gtggccatcc                                                   20


<210>  1396
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1396
tggggaccat gaggtggggc                                                   20


<210>  1397
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1397
ggagccccaa ggcccgctgg                                                   20


<210>  1398
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1398
tctctgagga acaagactca                                                   20


<210>  1399
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1399
gctgtagccc ctgccgctct                                                   20


<210>  1400
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1400
cccagtgaag aaggcaaaag                                                   20


<210>  1401
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1401
agctatgtga tgaagcaggc                                                   20


<210>  1402
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1402
tctgaccctc ctggtccccc                                                   20


<210>  1403
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1403
cacatcctat cccaccagtt                                                   20


<210>  1404
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1404
accatccccg gccgcctgca                                                   20


<210>  1405
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1405
catcacaccc atctttgcct                                                   20


<210>  1406
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1406
aatcagtggg ccatggtgac                                                   20


<210>  1407
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1407
ctttgcatcc acacagagtc                                                   20


<210>  1408
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1408
actagccctc caggacctgc                                                   20


<210>  1409
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1409
tgctgaccaa ccaggagaga                                                   20


<210>  1410
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1410
agcgattctc caggcaagga                                                   20


<210>  1411
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1411
aatcaggctt ccctggcttg                                                   20


<210>  1412
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1412
cctaccgcag cctgttataa                                                   20


<210>  1413
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1413
ccaccagccc tccctgtggt                                                   20


<210>  1414
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1414
ctcatggctg aagctgtgtt                                                   20


<210>  1415
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1415
tgcggagtct ctcggccccc                                                   20


<210>  1416
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1416
ccacaccggg gaggtgggct                                                   20


<210>  1417
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1417
acagtacagc tcactcagtg                                                   20


<210>  1418
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1418
caggtcaggc cagctggggc                                                   20


<210>  1419
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1419
gagcaagcca tggcacattg                                                   20


<210>  1420
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1420
aggcctggac tgtagagaca                                                   20


<210>  1421
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1421
cttgggtcag gctgattcag                                                   20


<210>  1422
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1422
ttctccccag tggggtctgg                                                   20


<210>  1423
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1423
catttaatca gggtcttgaa                                                   20


<210>  1424
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1424
cgggcacagt gcggatgcgt                                                   20


<210>  1425
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1425
cctgacccca agggagaccc                                                   20


<210>  1426
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1426
cctgaagtgt ctggaccaaa                                                   20


<210>  1427
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1427
ttggctagca gctgctgcag                                                   20


<210>  1428
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1428
gcctgaggcc gtggagacag                                                   20


<210>  1429
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1429
tgggtcatcg tctttgaaaa                                                   20


<210>  1430
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1430
agatcagttg taccagatgc                                                   20


<210>  1431
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1431
gttgagaggc tatgtgtgac                                                   20


<210>  1432
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1432
ctcacaggtc ccaaaacggt                                                   20


<210>  1433
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1433
gatgttctag gaagctcggc                                                   20


<210>  1434
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1434
ggacctaggc gaggcagtag                                                   20


<210>  1435
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1435
acacagagtg ctgagcggtg                                                   20


<210>  1436
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1436
ccctcactgg cggcttttcc                                                   20


<210>  1437
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1437
ccagatttga aaggaaaacg                                                   20


<210>  1438
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1438
gctgagcccc aaggtcctcc                                                   20


<210>  1439
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1439
gtcggaggcc cctggcaagg                                                   20


<210>  1440
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1440
acaggacccc gctggccagg                                                   20


<210>  1441
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1441
ttgtcatgaa gatgcacaat                                                   20


<210>  1442
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1442
tcatcaagaa ggtgcctctt                                                   20


<210>  1443
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1443
cctaggagaa agggcttgga                                                   20


<210>  1444
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1444
gctagcggtg atagtcagcc                                                   20


<210>  1445
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1445
gagagctgat agaagactct                                                   20


<210>  1446
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1446
cctcaactgc cagactgcag                                                   20


<210>  1447
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1447
tgctaggtga ccttggcctc                                                   20


<210>  1448
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1448
cgagtctagc catccgctgt                                                   20


<210>  1449
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1449
cccagcatcg gctccgtctc                                                   20


<210>  1450
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1450
ggggacgcag gcctggagaa                                                   20


<210>  1451
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1451
tcgctagcgg cttttcctgg                                                   20


<210>  1452
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1452
cctggcagcc tatgagtcct                                                   20


<210>  1453
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1453
acctcaggca cggcagtgga                                                   20


<210>  1454
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1454
tcctgtagga gtttgccagc                                                   20


<210>  1455
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1455
taaagggcat gctcatctcc                                                   20


<210>  1456
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1456
gaagagatcg cctggtgccc                                                   20


<210>  1457
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1457
aaagacctcc gaggaatccc                                                   20


<210>  1458
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1458
gctgcatgtc tctgcgtcca                                                   20


<210>  1459
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1459
cactatcttg ccccaggctc                                                   20


<210>  1460
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1460
taccttaaca agctcccgtg                                                   20


<210>  1461
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1461
cgtgcaggaa agagcagtgg                                                   20


<210>  1462
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1462
tctagctgag atccgggaga                                                   20


<210>  1463
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1463
catcagggac gcccaggcta                                                   20


<210>  1464
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1464
cccttcgagc tggtagcgcc                                                   20


<210>  1465
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1465
aggcagaaac cagtgcaagc                                                   20


<210>  1466
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1466
taccacctgc tggaggggtc                                                   20


<210>  1467
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1467
tcaggtcatt ccatggggga                                                   20


<210>  1468
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1468
ccggatgata tgggaaagaa                                                   20


<210>  1469
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1469
catcaagtgg catatctatc                                                   20


<210>  1470
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1470
gctgaagaaa aaggcaacaa                                                   20


<210>  1471
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1471
cccagttctt ctgcacatat                                                   20


<210>  1472
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1472
gcaccaagaa cacgccccag                                                   20


<210>  1473
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1473
attttaaggg tcagggtttg                                                   20


<210>  1474
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1474
gaataagatc gaggacttga                                                   20


<210>  1475
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1475
gctcagaatg gctgggtctc                                                   20


<210>  1476
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1476
ggtcaaggga ccggaatttg                                                   20


<210>  1477
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1477
caaggacagc tactggacgc                                                   20


<210>  1478
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1478
ccacgccagg gaggtgggct                                                   20


<210>  1479
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1479
gtgccagcta cagggaagga                                                   20


<210>  1480
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1480
accagacatg ccaggtccta                                                   20


<210>  1481
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1481
gccaatccta ttcagggcca                                                   20


<210>  1482
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1482
aattcagtga atgtagtatt                                                   20


<210>  1483
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1483
tgctcagtac atggtgctga                                                   20


<210>  1484
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1484
tgcactcaag tctgcacatc                                                   20


<210>  1485
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1485
cctgggagca ttggagattt                                                   20


<210>  1486
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1486
cagaggtctc caggtttgcc                                                   20


<210>  1487
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1487
atgttgctat tgctgctgtt                                                   20


<210>  1488
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1488
actcaaggta ctggcgctgg                                                   20


<210>  1489
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1489
gcccaatgtt atcgagatga                                                   20


<210>  1490
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1490
aattactttt gcctagtgct                                                   20


<210>  1491
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1491
cgagcaactc cgcatccctg                                                   20


<210>  1492
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1492
gaaatagctg agcatcaatg                                                   20


<210>  1493
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1493
caccgacccg caggagactg                                                   20


<210>  1494
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1494
caagaccaac aggcctttcc                                                   20


<210>  1495
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1495
acctactccc ccaggaactc                                                   20


<210>  1496
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1496
tgactacagc ttgtaccccc                                                   20


<210>  1497
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1497
ccccgccaag ttcacccctg                                                   20


<210>  1498
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1498
gttctagaac attaacccga                                                   20


<210>  1499
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1499
atgatgtccc tgcagctgcg                                                   20


<210>  1500
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1500
atcagctgga gttgttgttc                                                   20


<210>  1501
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1501
ccagatcctc ctgggccatc                                                   20


<210>  1502
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1502
cccaggctcc caggcagggc                                                   20


<210>  1503
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1503
cctcatccca ggcaaaaatg                                                   20


<210>  1504
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1504
gaaggccgac cggtcggcga                                                   20


<210>  1505
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1505
ccctacaggg ccccaggccc                                                   20


<210>  1506
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1506
ctcccaggtc atctctgcca                                                   20


<210>  1507
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1507
acgtgcagcg gaaggctgat                                                   20


<210>  1508
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1508
gttcccacgc atacacgtct                                                   20


<210>  1509
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1509
ccttagtctg gccagttctt                                                   20


<210>  1510
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1510
cttctagagg gtgctgttca                                                   20


<210>  1511
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1511
gagccggaca acccgggcaa                                                   20


<210>  1512
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1512
cccgccacgc caggaatgtc                                                   20


<210>  1513
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1513
cctcaggtgg cccaacggcc                                                   20


<210>  1514
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1514
accacctagg ccagcttgaa                                                   20


<210>  1515
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1515
ttgtgatggc cacaaccatg                                                   20


<210>  1516
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1516
cgtggatcac gcctgggggc                                                   20


<210>  1517
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1517
gctagctcca aaggagagag                                                   20


<210>  1518
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1518
ggttccccag atgattctgg                                                   20


<210>  1519
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1519
gctactgcaa cacagccacc                                                   20


<210>  1520
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1520
ggactacatc tgtggctgga                                                   20


<210>  1521
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1521
ccaagtcctc agggtcttct                                                   20


<210>  1522
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1522
gttgtagcgg agaagggcag                                                   20


<210>  1523
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1523
gcagcacctg cacatgctgg                                                   20


<210>  1524
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1524
ctgaggctgc ccctggacgc                                                   20


<210>  1525
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1525
ctcttagtgg ctctgctgat                                                   20


<210>  1526
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1526
aatgatgctc agggacctcc                                                   20


<210>  1527
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1527
gaatgatgaa actggacctc                                                   20


<210>  1528
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1528
gccgctagac aatgggagtg                                                   20


<210>  1529
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1529
agacctctag aagtccttga                                                   20


<210>  1530
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1530
cctttagagt agctgcctga                                                   20


<210>  1531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1531
gcggctacac ctgtcatggg                                                   20


<210>  1532
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1532
actgctaccc atatatccag                                                   20


<210>  1533
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1533
cctcaaggac cggcaggccc                                                   20


<210>  1534
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1534
gttcgaggag ctggtggcag                                                   20


<210>  1535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1535
gcctcagctc tgccctcaac                                                   20


<210>  1536
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1536
ggcctgtagg gtttcattaa                                                   20


<210>  1537
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1537
gttcctgcag ttgttctcca                                                   20


<210>  1538
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1538
aagcacatga ggcattctgg                                                   20


<210>  1539
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1539
gggctaagtg gggtacacgc                                                   20


<210>  1540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1540
caaaatactt aggagaaaaa                                                   20


<210>  1541
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1541
gtcatctaag acccactcac                                                   20


<210>  1542
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1542
gagggctaag ccagcaggtg                                                   20


<210>  1543
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1543
agatacccct ccatccggag                                                   20


<210>  1544
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1544
ccgcctccac gtcgcctcca                                                   20


<210>  1545
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1545
caactcactt cagctcctca                                                   20


<210>  1546
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1546
tctatgtccc ccgaaggaca                                                   20


<210>  1547
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1547
ccgtcatgtg ggtcctgaat                                                   20


<210>  1548
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1548
tttctacttc tggaacagct                                                   20


<210>  1549
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1549
tcctgcagcc caggcaggcc                                                   20


<210>  1550
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1550
cgtagtgaaa atggctctcc                                                   20


<210>  1551
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1551
aatatgccaa tgcaagtccc                                                   20


<210>  1552
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1552
ctcccctcaa ggatcacgtt                                                   20


<210>  1553
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1553
tgcagcccac acctgccgcc                                                   20


<210>  1554
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1554
aacagtgttg ttggtcccac                                                   20


<210>  1555
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1555
gatctacagg ctcaggcacc                                                   20


<210>  1556
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1556
gtggcagcca gcaataggca                                                   20


<210>  1557
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1557
ggcctacttt ggaggtgatg                                                   20


<210>  1558
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1558
gatcaggggt gtcctcgggg                                                   20


<210>  1559
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1559
ccatagtttg gactggatat                                                   20


<210>  1560
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1560
gcaacatctg cactctcgtg                                                   20


<210>  1561
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1561
agcagactgg atgggaaacc                                                   20


<210>  1562
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1562
gaacatcctg gggacgactc                                                   20


<210>  1563
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1563
cttctcacct gctggatgga                                                   20


<210>  1564
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1564
gggttagaat gacccagata                                                   20


<210>  1565
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1565
ccctgatccc gaaggaggaa                                                   20


<210>  1566
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1566
gcgctacctc gaggccttgg                                                   20


<210>  1567
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1567
cgtgatgagg tcggtcctgc                                                   20


<210>  1568
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1568
tgcggcagga cacttgtgcc                                                   20


<210>  1569
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1569
tgcacgagct cctccggccc                                                   20


<210>  1570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1570
gtcagtgtac caggatgcag                                                   20


<210>  1571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1571
tcactgggcg acgggcccct                                                   20


<210>  1572
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1572
tccaggcggc aagagagaag                                                   20


<210>  1573
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1573
gctttaaggc ttgcccaagg                                                   20


<210>  1574
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1574
gagtcctact tggccaggcc                                                   20


<210>  1575
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1575
agtagccctg ctggagtccg                                                   20


<210>  1576
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1576
cccagtcctg ctggttcccg                                                   20


<210>  1577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1577
ccaaggcccc ctggccatcc                                                   20


<210>  1578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1578
tgcttagggt ccagccattc                                                   20


<210>  1579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1579
tttcaacatg gcccatgggc                                                   20


<210>  1580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1580
ctgcactggg gaaggcccgg                                                   20


<210>  1581
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1581
agtctcactc cccctcctgc                                                   20


<210>  1582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1582
ggtcaggcca gtgcccatgg                                                   20


<210>  1583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1583
tatgatggtg gttttcaaac                                                   20


<210>  1584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1584
gcctcagcac acaaagtggt                                                   20


<210>  1585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1585
aggtccacgc ccgtcagctg                                                   20


<210>  1586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1586
cagggcatga tggtgggcat                                                   20


<210>  1587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1587
atgtgtgtga atcctggagg                                                   20


<210>  1588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1588
ccgctagccc acatgcacag                                                   20


<210>  1589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1589
ccagaccctc ccggtccccc                                                   20


<210>  1590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1590
tcctacagcg ccacaccgct                                                   20


<210>  1591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1591
gaactattca tactggaagc                                                   20


<210>  1592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1592
cttaccggac gtcagtgatc                                                   20


<210>  1593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1593
cctagagctc ctggcgagag                                                   20


<210>  1594
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1594
gctgaccctc caggcttccc                                                   20


<210>  1595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1595
ccctactgtc ccacatgggc                                                   20


<210>  1596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1596
caggcaagcc tggctgctgg                                                   20


<210>  1597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1597
ctcttagccg tgcgtcagga                                                   20


<210>  1598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1598
tggccatgag gaacaccacg                                                   20


<210>  1599
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1599
gtcagcctcg cttgaccctc                                                   20


<210>  1600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1600
ggagtcctac aggcctgggc                                                   20


<210>  1601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1601
ccagatccca gcggttctcc                                                   20


<210>  1602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1602
tctagtcagg aggatggcaa                                                   20


<210>  1603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1603
ttccctgagc tgtacaaaca                                                   20


<210>  1604
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1604
cccagctgct gtgggtcaga                                                   20


<210>  1605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1605
aaattctact ggcttgtatt                                                   20


<210>  1606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1606
ggggtcaggg gacagccttg                                                   20


<210>  1607
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1607
cggagagaga aaggagaacg                                                   20


<210>  1608
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1608
tgtggaggct gcagctacac                                                   20


<210>  1609
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1609
gtctcatgcc tgctcgtggc                                                   20


<210>  1610
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1610
acagctctaa gagtgaagac                                                   20


<210>  1611
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1611
ggtatatggc agctttggcc                                                   20


<210>  1612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1612
agaattagat ctggatcatt                                                   20


<210>  1613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1613
gtggttaagg ggacagctgc                                                   20


<210>  1614
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1614
aaaagggctc caggacccaa                                                   20


<210>  1615
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1615
attagtccac catgttcttc                                                   20


<210>  1616
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1616
gaactagcca tcaatactgt                                                   20


<210>  1617
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1617
cacagactgc caggctatct                                                   20


<210>  1618
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1618
cacctacaag tccctgccca                                                   20


<210>  1619
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1619
tggcccacat gttctaccac                                                   20


<210>  1620
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1620
ggactcagtt ggcaaatcgg                                                   20


<210>  1621
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1621
ggctctacag tgggccggtg                                                   20


<210>  1622
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1622
gggctgattt gccatccgag                                                   20


<210>  1623
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1623
ggagtaggag tacagagacg                                                   20


<210>  1624
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1624
ggtgcagggc ggggtggagg                                                   20


<210>  1625
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1625
caagcagaac cggccacccc                                                   20


<210>  1626
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1626
cctgatgccc ctggcgctcc                                                   20


<210>  1627
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1627
gctggaggct taggcttccc                                                   20


<210>  1628
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1628
cctgaagaaa gaggaggtct                                                   20


<210>  1629
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1629
gtggactgtg ctgtgggagt                                                   20


<210>  1630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1630
acatttcatc catcctctcc                                                   20


<210>  1631
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1631
tgttcactca gcagcatttg                                                   20


<210>  1632
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1632
tgacttgcac aggtaggggg                                                   20


<210>  1633
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1633
aggggtaaag ggtcaaagcg                                                   20


<210>  1634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1634
ctcctaagaa ggggacattg                                                   20


<210>  1635
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1635
gcaccatggg cgtcttcaca                                                   20


<210>  1636
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1636
tcctgatggt aaaggcgaaa                                                   20


<210>  1637
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1637
atgttgtgca tggtcactgg                                                   20


<210>  1638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1638
tgttccaaaa gtctgagttg                                                   20


<210>  1639
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1639
ccatgaggga accaggtgag                                                   20


<210>  1640
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1640
cacgtgaatg aagcatacga                                                   20


<210>  1641
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1641
gcaacaagtt gggtggctgg                                                   20


<210>  1642
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1642
ccaagcctct ccggccccgt                                                   20


<210>  1643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1643
cctgatctca gaggtgaaat                                                   20


<210>  1644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1644
gtcttagtcc cactggaaga                                                   20


<210>  1645
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1645
cctcagggac cagcaggacc                                                   20


<210>  1646
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1646
ttcagtctcg tgtatcttct                                                   20


<210>  1647
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1647
actatgtgca gtggaagact                                                   20


<210>  1648
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1648
gccagcccta cttgttctcg                                                   20


<210>  1649
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1649
gtgagttctg ctgcatcacc                                                   20


<210>  1650
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1650
atcacaagcc ccaatggctg                                                   20


<210>  1651
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1651
tcccctccat gtctgggtac                                                   20


<210>  1652
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1652
tctgcaggat gccgttgtcc                                                   20


<210>  1653
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1653
gatgacagag gagctgaaga                                                   20


<210>  1654
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1654
ccagatggtg gatgtggaac                                                   20


<210>  1655
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1655
ccatgcctag taccaggcta                                                   20


<210>  1656
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1656
gtggtgaatg gacatgatga                                                   20


<210>  1657
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1657
gctgaaagtc gtggtgatgg                                                   20


<210>  1658
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1658
gcagctatgt ccacacctgg                                                   20


<210>  1659
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1659
gtagcggcag tggaactcac                                                   20


<210>  1660
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1660
cctagtcctg cagtcaaaag                                                   20


<210>  1661
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1661
tcatcatggc gggccttcga                                                   20


<210>  1662
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1662
gagtatgggg tatgccgttg                                                   20


<210>  1663
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1663
agggttatcc cttggcatag                                                   20


<210>  1664
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1664
gctagttcaa cttctccatg                                                   20


<210>  1665
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1665
ccctagatcc cctggtgcta                                                   20


<210>  1666
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1666
acagcatccg gccatggccc                                                   20


<210>  1667
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1667
agcagcagcc tttgcccccg                                                   20


<210>  1668
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1668
cctgatttac ctggcactcc                                                   20


<210>  1669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1669
acgcgatcat cccttctttc                                                   20


<210>  1670
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1670
ccaggcagat atctgtcaga                                                   20


<210>  1671
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1671
cccctagggg ccgggagcac                                                   20


<210>  1672
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1672
gggccaccag gtcccgaggg                                                   20


<210>  1673
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1673
ggggctaggg ttggacaagc                                                   20


<210>  1674
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1674
gcgctaccgt aacggcacat                                                   20


<210>  1675
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1675
gtggcaatca tttccctaaa                                                   20


<210>  1676
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1676
tgctgtcact tccttcgaga                                                   20


<210>  1677
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1677
cctgagccat ctggtccccg                                                   20


<210>  1678
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1678
aaagcaggcc ctccgctggc                                                   20


<210>  1679
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1679
cccttaggcc ccaggccgag                                                   20


<210>  1680
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1680
caggctaccc ttggaggtcg                                                   20


<210>  1681
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1681
ctgctaccac agcttctcct                                                   20


<210>  1682
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1682
ccagggacgc cctggctacc                                                   20


<210>  1683
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1683
agcatccatt attgcagatc                                                   20


<210>  1684
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1684
aactgatcct tatacctgtt                                                   20


<210>  1685
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1685
tggctagcag tgcagggaca                                                   20


<210>  1686
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1686
tgtcactggg caaagtggtc                                                   20


<210>  1687
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1687
cgtggagaaa gaggtaggcc                                                   20


<210>  1688
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1688
aagcagctcc aggctttcca                                                   20


<210>  1689
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1689
caactagaac tcccgtaatt                                                   20


<210>  1690
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1690
aatgacttac ctgggaaccc                                                   20


<210>  1691
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1691
gctgagccct ggcgctgctt                                                   20


<210>  1692
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1692
agtggagcag cagcaagcgt                                                   20


<210>  1693
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1693
cttatgggtc tggcaggctg                                                   20


<210>  1694
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1694
ctcctagctg gagctgcacc                                                   20


<210>  1695
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1695
ccagcttcac caggtctcga                                                   20


<210>  1696
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1696
ctgaccggga ggccgcgctg                                                   20


<210>  1697
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1697
cactggccat aagattattg                                                   20


<210>  1698
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1698
ccattagtag gctcggcgct                                                   20


<210>  1699
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1699
tttgttccca gagctctacc                                                   20


<210>  1700
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1700
acagcgacca gctggggcag                                                   20


<210>  1701
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1701
ccgccgctag tagtacccgc                                                   20


<210>  1702
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1702
atgagtgtcc ggagcagctg                                                   20


<210>  1703
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1703
gcaggatcag gttcactcct                                                   20


<210>  1704
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1704
ggccgtggac gagttcgacg                                                   20


<210>  1705
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1705
tagcagccgg tgaagtgggc                                                   20


<210>  1706
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1706
cggcctatgt agttgaagct                                                   20


<210>  1707
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1707
ccacatgtcc tgtaagtact                                                   20


<210>  1708
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1708
cggacgcccg gctgctcctg                                                   20


<210>  1709
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1709
ggtaggttat ggtcttcaaa                                                   20


<210>  1710
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1710
aaggccacct ggggtaaggt                                                   20


<210>  1711
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1711
gttagccgaa ctggagaagt                                                   20


<210>  1712
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1712
cttagctggg gctgcgggag                                                   20


<210>  1713
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1713
ggccctcatt caccctgggt                                                   20


<210>  1714
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1714
gttctagatg tccacccgct                                                   20


<210>  1715
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1715
gccccagcct aagcagcgcg                                                   20


<210>  1716
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1716
gcccaggttg gaagaagctg                                                   20


<210>  1717
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1717
gagctatcgc acatccagat                                                   20


<210>  1718
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1718
cgtagagaac agggcctccc                                                   20


<210>  1719
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1719
tggctatcag ttgcaaaaaa                                                   20


<210>  1720
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1720
atccccatgg ggaaagaggt                                                   20


<210>  1721
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1721
gtgtcagccc ttggtgtcca                                                   20


<210>  1722
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1722
agagatgaaa ttggtaaccc                                                   20


<210>  1723
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1723
cagacaggca ggcccatcag                                                   20


<210>  1724
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1724
cctagcgcag ctggtaccag                                                   20


<210>  1725
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1725
gcctcaactc agctgctcaa                                                   20


<210>  1726
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1726
ccatgactgg acggtaaggg                                                   20


<210>  1727
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1727
gggtttacag gcgtgtttta                                                   20


<210>  1728
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1728
catcatgcct ccatcatttc                                                   20


<210>  1729
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1729
ccggcttcca ccgcttccgc                                                   20


<210>  1730
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1730
ccgtcatgct gttgctgagc                                                   20


<210>  1731
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1731
ctccatgtcc caggtcacgc                                                   20


<210>  1732
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1732
ttggcctact caaagttacc                                                   20


<210>  1733
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1733
cctagtggta aaggagaaag                                                   20


<210>  1734
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1734
ctgctactcg gcgatgcgct                                                   20


<210>  1735
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1735
cctcaacgcc gttcgggcac                                                   20


<210>  1736
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1736
ccgagacccc acacacctgc                                                   20


<210>  1737
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1737
atcatcccat aagccccact                                                   20


<210>  1738
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1738
cagtattttc atggatagga                                                   20


<210>  1739
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1739
tcaggccacc ctcatctgcc                                                   20


<210>  1740
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1740
cagggcctag gagaagtccc                                                   20


<210>  1741
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1741
ctcgggggac ggggacagcg                                                   20


<210>  1742
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1742
tctctaggga acaagactca                                                   20


<210>  1743
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1743
ggggcaatca tctccctcct                                                   20


<210>  1744
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1744
ccactagatg cgctctttga                                                   20


<210>  1745
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1745
gatgaatggc tgcaggctgg                                                   20


<210>  1746
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1746
gtcgatccag ctggaaagag                                                   20


<210>  1747
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1747
ggggatgagt gtgttgttga                                                   20


<210>  1748
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1748
gttagaagag tgcttggact                                                   20


<210>  1749
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1749
atggtacgga ggccctggag                                                   20


<210>  1750
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1750
cgcgtctagg atgcttacac                                                   20


<210>  1751
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1751
cagccactca ctgtttctat                                                   20


<210>  1752
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1752
cccaatgggc ggtttgtcat                                                   20


<210>  1753
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1753
cctcaggcac cagggaagcc                                                   20


<210>  1754
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1754
cccctggcta cgggggaatg                                                   20


<210>  1755
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1755
gcaatatgtg tggccacttg                                                   20


<210>  1756
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1756
acctcactct ccagccttgc                                                   20


<210>  1757
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1757
actgactggg gagaaaccca                                                   20


<210>  1758
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1758
aagtgactgg ccaacttctg                                                   20


<210>  1759
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1759
gtttaggggt aagtccggca                                                   20


<210>  1760
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1760
tccacttgaa gaagccgacc                                                   20


<210>  1761
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1761
ttctcacttt tcgacaggag                                                   20


<210>  1762
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1762
caggcaggca gccaggatca                                                   20


<210>  1763
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1763
agccctacga ggaggattcg                                                   20


<210>  1764
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1764
gctacctctg gtaccagtca                                                   20


<210>  1765
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1765
agcaagggtc ccctacccac                                                   20


<210>  1766
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1766
tcatagctat cactatggag                                                   20


<210>  1767
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1767
gcgtagagcc gcgataaccc                                                   20


<210>  1768
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1768
ccatcgtgct gttgctgagc                                                   20


<210>  1769
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1769
tctggaactg ctgatggctc                                                   20


<210>  1770
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1770
attttaaggt tcaacccctt                                                   20


<210>  1771
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1771
accaccatgt ctgacacctt                                                   20


<210>  1772
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1772
cactcagatt ctgtgtccaa                                                   20


<210>  1773
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1773
aatgacccac aacactgagc                                                   20


<210>  1774
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1774
ttctgcacat ggcggtcact                                                   20


<210>  1775
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1775
ctactaccag tgcaagctgg                                                   20


<210>  1776
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1776
gtaacgacag acttctcctc                                                   20


<210>  1777
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1777
tcgcagaaaa cggtgcgcac                                                   20


<210>  1778
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1778
cgagaacggc caggacttcc                                                   20


<210>  1779
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1779
gtatgctagc tttgcgagtt                                                   20


<210>  1780
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1780
cccaggcctt ccggccttgc                                                   20


<210>  1781
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1781
cggtgcagaa gagggactgg                                                   20


<210>  1782
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1782
caggagcagc acctggaagc                                                   20


<210>  1783
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1783
tcattgatgg tgatgtcctc                                                   20


<210>  1784
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1784
acaagacatt cgtggcgata                                                   20


<210>  1785
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1785
aaagcactac actgaagacc                                                   20


<210>  1786
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1786
ggccggcaac gtctttagct                                                   20


<210>  1787
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1787
caactaaaag agtgccagcc                                                   20


<210>  1788
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1788
cgcagggcat caactgggag                                                   20


<210>  1789
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1789
aatctcacac acgaaattgt                                                   20


<210>  1790
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1790
cggttacagt cactgatagt                                                   20


<210>  1791
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1791
gaactagtag atgccgttca                                                   20


<210>  1792
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1792
accaccaccg tggacgtcgt                                                   20


<210>  1793
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1793
ggccaggctg ctggggctgc                                                   20


<210>  1794
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1794
aggtccagca catcttctcc                                                   20


<210>  1795
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1795
cctgaatggc caggcctgaa                                                   20


<210>  1796
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1796
aggctgatac ttctacattc                                                   20


<210>  1797
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1797
cctaggaacg atggtccccc                                                   20


<210>  1798
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1798
aacgatgctc ctggtgaagc                                                   20


<210>  1799
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1799
gaatgacatc aacctggcac                                                   20


<210>  1800
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1800
acagatgaac gtggagctgc                                                   20


<210>  1801
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1801
aggcaatgta cataaatctg                                                   20


<210>  1802
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1802
atggaggtaa aagggactat                                                   20


<210>  1803
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1803
cttattcgat gaagctggcc                                                   20


<210>  1804
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1804
tgcagccgca gatcccgatc                                                   20


<210>  1805
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1805
tctctctaaa atcactgagc                                                   20


<210>  1806
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1806
ggactacaat agattcccgc                                                   20


<210>  1807
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1807
tcccaaatct ccctagaacg                                                   20


<210>  1808
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1808
tgaggctgcg gcagcccgcc                                                   20


<210>  1809
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1809
tacttcaaca cagtgccaca                                                   20


<210>  1810
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1810
cccagaagtc caggaggacc                                                   20


<210>  1811
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1811
tgtcaccctg actgcgggcc                                                   20


<210>  1812
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1812
cctgatcatc caggcccacc                                                   20


<210>  1813
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1813
tcactgacag acagtggccc                                                   20


<210>  1814
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1814
gcgagcagca cgagtttgcg                                                   20


<210>  1815
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1815
ttcctacttg gagtgatttc                                                   20


<210>  1816
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1816
ccagtgaaag cactattgac                                                   20


<210>  1817
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1817
ctagccaaca ttgttttgtg                                                   20


<210>  1818
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1818
tggctcaaac cagaggcttc                                                   20


<210>  1819
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1819
gaacaatcta caagggaaag                                                   20


<210>  1820
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1820
gacagaggga gtactcggcg                                                   20


<210>  1821
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1821
tccggagcag catccacaca                                                   20


<210>  1822
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1822
gaagaggcag ctggttccac                                                   20


<210>  1823
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1823
ggactacaga gtagtccggc                                                   20


<210>  1824
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1824
cccactcctg gatcaaataa                                                   20


<210>  1825
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1825
aaggacgaca gaggtttgcc                                                   20


<210>  1826
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1826
tggcctgaca cgttctcatg                                                   20


<210>  1827
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1827
tgcttaagag aggtagaagg                                                   20


<210>  1828
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1828
gtttcaataa gcccgacgga                                                   20


<210>  1829
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1829
caaaggacac agagccaaat                                                   20


<210>  1830
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1830
tgctcccagg catacacatc                                                   20


<210>  1831
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1831
tgactgatgt aaatacaatg                                                   20


<210>  1832
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1832
tgaccttata tgttggtgtg                                                   20


<210>  1833
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1833
ctcagctgac cgatcgcttc                                                   20


<210>  1834
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1834
gctgaaccaa atggcatccc                                                   20


<210>  1835
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1835
tggtatccct ttggatttga                                                   20


<210>  1836
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1836
gcatccacta tcccagtaag                                                   20


<210>  1837
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1837
caaaccaccc actgggctgc                                                   20


<210>  1838
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1838
ggtccccagg gcctcaaggt                                                   20


<210>  1839
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1839
cgcaggctga agggcgaccg                                                   20


<210>  1840
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1840
agccaagtca gcgctgctcg                                                   20


<210>  1841
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1841
ttagtaatac ttgtgggcca                                                   20


<210>  1842
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1842
cctgatgaac ctgggcaagc                                                   20


<210>  1843
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1843
cacggacgtg gcggccgccg                                                   20


<210>  1844
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1844
agaactactc cacagggttc                                                   20


<210>  1845
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1845
gtccaaggct tgcagctgcc                                                   20


<210>  1846
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1846
aataatgcca gagcattaga                                                   20


<210>  1847
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1847
ccagaggtga agggtcaaag                                                   20


<210>  1848
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1848
tactggagaa cggcaaccac                                                   20


<210>  1849
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1849
ggacaccatt cagcggactg                                                   20


<210>  1850
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1850
acctagtgtg gttggtgctg                                                   20


<210>  1851
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1851
aggcccaaga tgagcacaca                                                   20


<210>  1852
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1852
ggttctagca catggagatg                                                   20


<210>  1853
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1853
ggtggcatgg ctcgggcctg                                                   20


<210>  1854
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1854
aaccagatgg acagccacac                                                   20


<210>  1855
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1855
ccatctcaac ctggggctcc                                                   20


<210>  1856
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1856
tggtctgcta gatggacagc                                                   20


<210>  1857
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1857
tgcgtcagat tctttctaga                                                   20


<210>  1858
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1858
tagttctcac tcagtggaca                                                   20


<210>  1859
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1859
tctcaacagc ctgtgggaga                                                   20


<210>  1860
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1860
agcagcaacg attgttggtg                                                   20


<210>  1861
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1861
ttcttattga gggctatgcc                                                   20


<210>  1862
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1862
agggccaaca cagtggaggg                                                   20


<210>  1863
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1863
cccagggacc tcggacctgt                                                   20


<210>  1864
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1864
accaaccacc actttctgat                                                   20


<210>  1865
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1865
aaggggcagg tgacaggctg                                                   20


<210>  1866
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1866
ccccaagttc ctgagatacc                                                   20


<210>  1867
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1867
gaaagtggaa tcacactgag                                                   20


<210>  1868
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1868
cctgaaattc caggacctcc                                                   20


<210>  1869
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1869
gcctaagtcc agggttcagg                                                   20


<210>  1870
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1870
gcaaaggtac cagcttagac                                                   20


<210>  1871
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1871
gccgatccta ctggtcctat                                                   20


<210>  1872
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1872
ctcaagtatg gctatgatgc                                                   20


<210>  1873
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1873
gacgcacatc aatgccaccc                                                   20


<210>  1874
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1874
gagggagaac gggccacagc                                                   20


<210>  1875
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1875
agagatgacc aaggacgtga                                                   20


<210>  1876
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1876
gccagtgcta ctggtgccag                                                   20


<210>  1877
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1877
gctgatcgcc ctggggagcc                                                   20


<210>  1878
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1878
tcaggcagcc ttgggctgct                                                   20


<210>  1879
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1879
gtactagaag atgcagtccc                                                   20


<210>  1880
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1880
agcgttatat attctctgtg                                                   20


<210>  1881
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1881
aaagatgaaa gaggatttcc                                                   20


<210>  1882
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1882
aagtccgagc aacggggccg                                                   20


<210>  1883
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1883
ggactatgac cagcatagaa                                                   20


<210>  1884
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1884
gggccacttg ttggctggct                                                   20


<210>  1885
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1885
ggcccaagag agtcttgccc                                                   20


<210>  1886
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1886
acgtgaaaca tctcgttcgc                                                   20


<210>  1887
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1887
agtcacagat cttcacttcc                                                   20


<210>  1888
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1888
agtcagagat gttcttgcac                                                   20


<210>  1889
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1889
accaagtgtt gctggtgctg                                                   20


<210>  1890
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1890
aagagtgaaa caggtgctcc                                                   20


<210>  1891
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1891
ctggaggggc gggaggcccc                                                   20


<210>  1892
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1892
aagagaagaa cctggacctc                                                   20


<210>  1893
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1893
cctagagaga aaggtgtgcc                                                   20


<210>  1894
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1894
ttgcaaacaa catgttggga                                                   20


<210>  1895
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1895
ggtggcaaga agcagagaat                                                   20


<210>  1896
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1896
tgtgctccat ggtgatggcc                                                   20


<210>  1897
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1897
atgtcgcagg gggcggcccc                                                   20


<210>  1898
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1898
agacagagca gccgtcgtgc                                                   20


<210>  1899
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1899
aaggaagaca tcggagtccc                                                   20


<210>  1900
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1900
aagaggccca gaggtcttcc                                                   20


<210>  1901
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1901
cccagacgac ctggagagcg                                                   20


<210>  1902
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1902
cgctactcgc agaggccgcc                                                   20


<210>  1903
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1903
cccagtgaaa aggggcccag                                                   20


<210>  1904
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1904
ataggcaacc tgcactggtg                                                   20


<210>  1905
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1905
tttttaggtt cacgctgctg                                                   20


<210>  1906
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1906
gctactggta gagctggtca                                                   20


<210>  1907
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1907
cgtgcaagac aggaagaggc                                                   20


<210>  1908
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1908
cccggaagcc cacagcacca                                                   20


<210>  1909
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1909
agtcagcccc aagggcccca                                                   20


<210>  1910
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1910
cgcagcaacc atggtggcat                                                   20


<210>  1911
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1911
tctgctagga gaagtagagg                                                   20


<210>  1912
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1912
gttattggta ttcagtattc                                                   20


<210>  1913
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1913
cttcaaagag caaggttgcc                                                   20


<210>  1914
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1914
gctcagatga tggtgtctgc                                                   20


<210>  1915
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1915
ccgccacctg gcggttggcg                                                   20


<210>  1916
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1916
caagcccaac aggcagagcc                                                   20


<210>  1917
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1917
ccagaagcta acggtctcag                                                   20


<210>  1918
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1918
gcagggcgac catggctctc                                                   20


<210>  1919
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1919
tgggagccat gaggtggggc                                                   20


<210>  1920
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1920
cccccatgat ggggacgact                                                   20


<210>  1921
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1921
gttgaaccca gtggacctcc                                                   20


<210>  1922
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1922
gatgatcgca ctggacatcc                                                   20


<210>  1923
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1923
tcctgaagac cctggcctgc                                                   20


<210>  1924
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1924
gggcggcagc tacgtgctct                                                   20


<210>  1925
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1925
actcaagatg actttgtgcg                                                   20


<210>  1926
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1926
atgccaggtg gcatgtttcc                                                   20


<210>  1927
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1927
aacagatgct cctggattaa                                                   20


<210>  1928
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1928
gccccagatg tcatcctcct                                                   20


<210>  1929
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1929
cgatgaacga aatggagaaa                                                   20


<210>  1930
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1930
gaaaagagat gaagggccta                                                   20


<210>  1931
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1931
ctcaccagac tacgagaccg                                                   20


<210>  1932
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1932
gaacgacatg aagtactacc                                                   20


<210>  1933
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1933
gccagaacca cctcctccgt                                                   20


<210>  1934
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1934
cctgacccaa ttggcccagc                                                   20


<210>  1935
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1935
tgccatgact gtggcctgcc                                                   20


<210>  1936
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1936
cgtagcgata agggagagcc                                                   20


<210>  1937
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1937
gttttaacag ctctccaccc                                                   20


<210>  1938
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1938
aaagaggaca ttggccctcc                                                   20


<210>  1939
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1939
accgcaggga ggccgccagc                                                   20


<210>  1940
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1940
tcaggaacct cctggaccac                                                   20


<210>  1941
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1941
ccccagaggt gttcacacac                                                   20


<210>  1942
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1942
gtcctagcag gtgcccccgt                                                   20


<210>  1943
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1943
cctctccacg gcgcggccat                                                   20


<210>  1944
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1944
tctagagaaa tggccagcgg                                                   20


<210>  1945
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1945
agaactattt gtttagttct                                                   20


<210>  1946
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1946
cgctcattta gggaaggaga                                                   20


<210>  1947
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1947
gcggtcagcc acctggctgg                                                   20


<210>  1948
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1948
tggttgattt gtcagcaatc                                                   20


<210>  1949
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1949
gacgaccaga atggcgtgcc                                                   20


<210>  1950
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1950
aactaagcga atttggataa                                                   20


<210>  1951
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1951
ttcctcgtga tcgcaggctt                                                   20


<210>  1952
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1952
aaagatcatg ctggtcttgc                                                   20


<210>  1953
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1953
cctagacaaa gaggagaacc                                                   20


<210>  1954
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1954
tccctaacag agcccgggga                                                   20


<210>  1955
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1955
agaaccacag agctaagcaa                                                   20


<210>  1956
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1956
acatcagcaa gcctttactt                                                   20


<210>  1957
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1957
ccagaccaac cctgctctgg                                                   20


<210>  1958
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1958
gcaaccagtt gtaccgcgag                                                   20


<210>  1959
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1959
taatcacttg gccatgtagt                                                   20


<210>  1960
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1960
ctttcacaca cagtagtccc                                                   20


<210>  1961
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1961
cgtccaggta gtgcgtcttc                                                   20


<210>  1962
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1962
tctcatcctc gggggccaac                                                   20


<210>  1963
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1963
cctcaagggc ctgtctgacc                                                   20


<210>  1964
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1964
cccaggtttc cagggagcaa                                                   20


<210>  1965
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1965
tgcaagcacc tgcaagaatg                                                   20


<210>  1966
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1966
ctaggcagga cacatctcac                                                   20


<210>  1967
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1967
cacacagagc tcattgtaga                                                   20


<210>  1968
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1968
gtgatgaaaa actctcccgc                                                   20


<210>  1969
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1969
tccccctgca catgcgggac                                                   20


<210>  1970
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1970
ttcactccag gtagggcaga                                                   20


<210>  1971
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1971
aaggatgaaa caggtgctcc                                                   20


<210>  1972
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1972
aaggtttaat aggcagctga                                                   20


<210>  1973
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1973
tctgatccta gtggactccc                                                   20


<210>  1974
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1974
tagagcttga ggttcacatc                                                   20


<210>  1975
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1975
atacattttt accaagaagt                                                   20


<210>  1976
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1976
ttgggaaggt tcttacatga                                                   20


<210>  1977
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1977
tatccactac aacccgctgc                                                   20


<210>  1978
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1978
cccgaccccc cagggccgcc                                                   20


<210>  1979
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1979
gcagtgctga gcagagcagc                                                   20


<210>  1980
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1980
cattcttaag tgtgaaggtc                                                   20


<210>  1981
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1981
gtgccggaag acggggctgc                                                   20


<210>  1982
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1982
aaggcagtag tttttagtaa                                                   20


<210>  1983
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1983
tgaagttgtc caggtgagcc                                                   20


<210>  1984
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1984
ccgatgatac cagtttcgag                                                   20


<210>  1985
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1985
ttacgtatat tcatggagta                                                   20


<210>  1986
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1986
cccaggttgc caggggctcc                                                   20


<210>  1987
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1987
cataggcatc atgtccatcc                                                   20


<210>  1988
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1988
tgaaagagcc acatataaag                                                   20


<210>  1989
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1989
ctcttctaca atatgtagct                                                   20


<210>  1990
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1990
attttatgca tctggtggaa                                                   20


<210>  1991
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1991
gcagctgtag tttagtccta                                                   20


<210>  1992
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1992
atgaaatctg gccagctttg                                                   20


<210>  1993
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1993
ttgcaagcaa aatagttctg                                                   20


<210>  1994
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1994
ccattatgtt gagattgggg                                                   20


<210>  1995
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1995
cagagagagc tggggcggat                                                   20


<210>  1996
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1996
gcagaacccc ctggaggttc                                                   20


<210>  1997
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1997
gcctagccct cggccatcgc                                                   20


<210>  1998
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1998
tgttgagtac cagggaatga                                                   20


<210>  1999
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1999
gctgcagcgc attgccagcc                                                   20


<210>  2000
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2000
catctcagta gacttttacc                                                   20


<210>  2001
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2001
ggaagctagg agctggggga                                                   20


<210>  2002
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2002
cgacctctac atggtctctc                                                   20


<210>  2003
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2003
ttggccaagt gcctgtgcgg                                                   20


<210>  2004
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2004
tcctagcact ccaggtcctc                                                   20


<210>  2005
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2005
gggctagaga aggacctgga                                                   20


<210>  2006
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2006
gttgaacgtg agccgcttct                                                   20


<210>  2007
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2007
gctcagcagg gcctgcaatt                                                   20


<210>  2008
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2008
accagaaagc atggggaaca                                                   20


<210>  2009
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2009
acaacagcat gccactggcc                                                   20


<210>  2010
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2010
gtatactgtt gatgtgtatg                                                   20


<210>  2011
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2011
ttaatcacag cttttggtcc                                                   20


<210>  2012
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2012
actttagtca gtttcctcat                                                   20


<210>  2013
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2013
gtcgcagtag ggcgcacgct                                                   20


<210>  2014
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2014
gcaagggccc caggacttag                                                   20


<210>  2015
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2015
ctagggggcc atggatgcta                                                   20


<210>  2016
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2016
cccagagaaa gatggcccaa                                                   20


<210>  2017
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2017
cagagtcttc ctggtctggc                                                   20


<210>  2018
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2018
cacatgatac gacctgcaga                                                   20


<210>  2019
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2019
gggctagaag aagcagtgca                                                   20


<210>  2020
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2020
gcggacacgg tacctgggct                                                   20


<210>  2021
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2021
ccagaacctc ctggtgctat                                                   20


<210>  2022
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2022
tctgccagaa gtccccgtag                                                   20


<210>  2023
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2023
ccagaagaga agggagaagc                                                   20


<210>  2024
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2024
tgctgacatt cgaggccctc                                                   20


<210>  2025
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2025
ttcgagggta tacatgggct                                                   20


<210>  2026
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2026
caccaaggat ctgatttagt                                                   20


<210>  2027
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2027
aatctaggat atatgtttct                                                   20


<210>  2028
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2028
aagagtgaaa acggtgttgt                                                   20


<210>  2029
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2029
gcagggcatg tctctgcaaa                                                   20


<210>  2030
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2030
tctcaggaga tgaagtcttc                                                   20


<210>  2031
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2031
ttctcctaag aatgggaata                                                   20


<210>  2032
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2032
cagcaaggcc tgcaggctgt                                                   20


<210>  2033
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2033
gactgagatg gtgatctcgt                                                   20


<210>  2034
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2034
gccagtgcta atggtgctcc                                                   20


<210>  2035
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2035
acactaattt ccgccaggta                                                   20


<210>  2036
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2036
ccacaaagac aatgtggtag                                                   20


<210>  2037
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2037
cgacagggac cagtcggtgg                                                   20


<210>  2038
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2038
taagatgcag gctctagagg                                                   20


<210>  2039
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2039
ggaagtgacg tgctgtgctg                                                   20


<210>  2040
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2040
aagcgttaaa tatcggcatc                                                   20


<210>  2041
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2041
aagctgcaat ctgaaaacaa                                                   20


<210>  2042
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2042
ccctggtgag acacctcctc                                                   20


<210>  2043
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2043
gtgaatgtag aggtctacag                                                   20


<210>  2044
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2044
tttcaacgcc cccgccaccg                                                   20


<210>  2045
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2045
atactacatc aggattttgc                                                   20


<210>  2046
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2046
tcctagcatt ccaggaaagg                                                   20


<210>  2047
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2047
accttagcac cttcttccac                                                   20


<210>  2048
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2048
gtcacgggaa actgatcctc                                                   20


<210>  2049
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2049
ggccaaccac aggtcggagg                                                   20


<210>  2050
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2050
gcgttccaag gaggacggcc                                                   20


<210>  2051
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2051
ccaccatgta ctctgcaggg                                                   20


<210>  2052
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2052
ctcaagggta aaattcgctg                                                   20


<210>  2053
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2053
atactacagg agagagaaga                                                   20


<210>  2054
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2054
ctaatcccct aaggaaacag                                                   20


<210>  2055
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2055
gttcaagaag aagtcgctgg                                                   20


<210>  2056
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2056
cggagtcttg caggaccacc                                                   20


<210>  2057
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2057
gtccggtatc taaaagacta                                                   20


<210>  2058
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2058
aaacaaaggt gcttcaataa                                                   20


<210>  2059
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2059
agttctcagg ctgtgtaata                                                   20


<210>  2060
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2060
taattcattc taattggttc                                                   20


<210>  2061
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2061
ggagggtaag gagtgcaggt                                                   20


<210>  2062
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2062
cctaggggcg ctcggccgcc                                                   20


<210>  2063
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2063
cccagggaga aggggagcat                                                   20


<210>  2064
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2064
gatagacagc ctgcactggt                                                   20


<210>  2065
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2065
cacaagcact ttttctgatt                                                   20


<210>  2066
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2066
tgtttcaagt gctggcagtg                                                   20


<210>  2067
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2067
gcccaagcct tgccggacgc                                                   20


<210>  2068
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2068
atctcattct gcaggcagca                                                   20


<210>  2069
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2069
cgggagtaga tgattagaaa                                                   20


<210>  2070
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2070
tggtgagaca ggatgtggcc                                                   20


<210>  2071
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2071
gctagtccag gggcagcacc                                                   20


<210>  2072
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2072
cactctattt ctgctggctg                                                   20


<210>  2073
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2073
cacccaccaa attccagctt                                                   20


<210>  2074
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2074
ggaggaaaaa gatgaacctt                                                   20


<210>  2075
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2075
caggagtctc ccctggggga                                                   20


<210>  2076
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2076
cctgacccag ctggccagcc                                                   20


<210>  2077
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2077
ccgtggagca gagctcgcag                                                   20


<210>  2078
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2078
aggaacagtt cattgatagc                                                   20


<210>  2079
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2079
tcttacagaa tgtagccttt                                                   20


<210>  2080
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2080
gtctcaaaca ttgtcctgaa                                                   20


<210>  2081
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2081
actaaggact ggcaggcact                                                   20


<210>  2082
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2082
cttcaggctg ccccggctgc                                                   20


<210>  2083
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2083
gcctgaccat caggaacatg                                                   20


<210>  2084
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2084
tcacactgac ccagacctgg                                                   20


<210>  2085
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2085
cagaagtgaa agaggatctg                                                   20


<210>  2086
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2086
ggcactgtga catcgatgag                                                   20


<210>  2087
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2087
ccagaattgg atggcatccc                                                   20


<210>  2088
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2088
gatcgaaaac gcggcggcgg                                                   20


<210>  2089
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2089
aaacgtccac gcggtgcggg                                                   20


<210>  2090
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2090
agcacacacc ttgtccaggt                                                   20


<210>  2091
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2091
ccttaggggc tttgcccctg                                                   20


<210>  2092
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2092
gaatgagctt cttgcagcaa                                                   20


<210>  2093
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2093
ctggcagtag taggggctga                                                   20


<210>  2094
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2094
ggagtcatga ggtacctgca                                                   20


<210>  2095
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2095
atgagcacga tgtagctata                                                   20


<210>  2096
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2096
ttccacttca ccggcacctg                                                   20


<210>  2097
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2097
ggcacacatc gaggagctgg                                                   20


<210>  2098
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2098
acaccaagcc ggctggctgc                                                   20


<210>  2099
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2099
ctcaggccac actgattcgc                                                   20


<210>  2100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2100
tctctaataa gcagtactgt                                                   20


<210>  2101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2101
tggtttgaac tggatatcgg                                                   20


<210>  2102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2102
cccagtcaag atggtattcc                                                   20


<210>  2103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2103
tccactatac tctcaaggat                                                   20


<210>  2104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2104
aagtcacaga cgcttctttt                                                   20


<210>  2105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2105
agcacagcat cgtcaccaac                                                   20


<210>  2106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2106
atgtgaagat tgccacctac                                                   20


<210>  2107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2107
tgcatgagcc gctctagcat                                                   20


<210>  2108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2108
gaaacagggt ttcaccatgt                                                   20


<210>  2109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2109
gaagaaaaga gaggccctaa                                                   20


<210>  2110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2110
tagtgcagca aaagcgcgcc                                                   20


<210>  2111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2111
caaagaagag tgcggcagcg                                                   20


<210>  2112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2112
agaaacatag gcacatccac                                                   20


<210>  2113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2113
tctcgcccaa ccccaacctc                                                   20


<210>  2114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2114
tttgattggt cctgttggct                                                   20


<210>  2115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2115
ttctcatgtg gaattttcca                                                   20


<210>  2116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2116
cctccaggag gggtaggggt                                                   20


<210>  2117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2117
gagtaccaga agagatacag                                                   20


<210>  2118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2118
cgatgaggta cttcagggtg                                                   20


<210>  2119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2119
attgaaccac cagggcctcg                                                   20


<210>  2120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2120
cgagtagcaa gaggtggaga                                                   20


<210>  2121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2121
ctgagtcagc atctgccagc                                                   20


<210>  2122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2122
tccagatagg tgtgctttgt                                                   20


<210>  2123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2123
tgatgacacc aagggagaaa                                                   20


<210>  2124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2124
agcactgacg tctgggggag                                                   20


<210>  2125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2125
ctgagattga gaaacctggg                                                   20


<210>  2126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2126
aagctttcaa catctgtgaa                                                   20


<210>  2127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2127
ggagcaaggt cctgctccga                                                   20


<210>  2128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2128
ctatcttttc ctctagagtc                                                   20


<210>  2129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2129
aagtcattgc tgtatgagcc                                                   20


<210>  2130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2130
agtccagcta aagccctggc                                                   20


<210>  2131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2131
cccaagtttt cctggcctcc                                                   20


<210>  2132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2132
catgaccatc cagaacgccc                                                   20


<210>  2133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2133
cctagagaac aaggaccccc                                                   20


<210>  2134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2134
tttgggtcaa ctgtccacct                                                   20


<210>  2135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2135
ggcctacatg tgtcctgcct                                                   20


<210>  2136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2136
ataccaccgg gcggcaaagc                                                   20


<210>  2137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2137
agatgagaaa gcttatctaa                                                   20


<210>  2138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2138
cgagacaagc cggggctccc                                                   20


<210>  2139
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2139
accctgctat gccagctggg                                                   20


<210>  2140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2140
tccaggttag gccacttcac                                                   20


<210>  2141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2141
cctgatgcta taggtccatc                                                   20


<210>  2142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2142
catccagctc ataaccctaa                                                   20


<210>  2143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2143
cttcaaggaa tgtgaggtat                                                   20


<210>  2144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2144
aggaccagag ggacctggga                                                   20


<210>  2145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2145
tattgtcaca gatactccag                                                   20


<210>  2146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2146
gggcctaggt tcggaatgcc                                                   20


<210>  2147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2147
tctacaggga cttccggcag                                                   20


<210>  2148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2148
tagccatgac ctaattattt                                                   20


<210>  2149
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2149
gctcaaagct gacccaccgt                                                   20


<210>  2150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2150
acaacataca aagtggggat                                                   20


<210>  2151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2151
cacaacactt ttgggggtga                                                   20


<210>  2152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2152
acagaacccc ctggtccaca                                                   20


<210>  2153
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2153
cagccatgcc ttgtcgcaga                                                   20


<210>  2154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2154
gagagtcaga agagatgcac                                                   20


<210>  2155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2155
ttcaatatgt tgatggagag                                                   20


<210>  2156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2156
aaaataaagt aggagtactc                                                   20


<210>  2157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2157
tgcagcagga gggaggtagg                                                   20


<210>  2158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2158
ccagaagaga agggatcgcc                                                   20


<210>  2159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2159
cgcgactact gcgcgcggga                                                   20


<210>  2160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2160
catcaacacc aacgtgcagg                                                   20


<210>  2161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2161
ttgttaaggg ctatgccggg                                                   20


<210>  2162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2162
gatggagaca ctgtacctgc                                                   20


<210>  2163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2163
ggggcacagg tagagctggg                                                   20


<210>  2164
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2164
cagagatgaa agaggatctg                                                   20


<210>  2165
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2165
aaatgacatc ccaggagaaa                                                   20


<210>  2166
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2166
gctagcccca atggatttgc                                                   20


<210>  2167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2167
ctaccttgcc catgaaatct                                                   20


<210>  2168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2168
aacaatacag cttttagaaa                                                   20


<210>  2169
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2169
cagctgtcag gctttggagc                                                   20


<210>  2170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2170
atctcagcca ggggggcctg                                                   20


<210>  2171
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2171
ggagcgacca ggaggccatc                                                   20


<210>  2172
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2172
ggcgccgtag gccacggccc                                                   20


<210>  2173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2173
tctagtccag gacccggtgc                                                   20


<210>  2174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2174
caggccacag ccaggggagg                                                   20


<210>  2175
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2175
ggagacgtag agggacagca                                                   20


<210>  2176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2176
gacaatgatg ttagatgcag                                                   20


<210>  2177
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2177
gttttagata gaccttaatg                                                   20


<210>  2178
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2178
cccagcgttg ctggggctcc                                                   20


<210>  2179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2179
gccgagcagg ctggccacca                                                   20


<210>  2180
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2180
catgaagtca tgtccccgga                                                   20


<210>  2181
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2181
agataagcag tccctccaaa                                                   20


<210>  2182
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2182
gttgataacg ctggtcctgc                                                   20


<210>  2183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2183
cagccacacc agtacttcat                                                   20


<210>  2184
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2184
ccacaggcac caggtgggcc                                                   20


<210>  2185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2185
ggaaccacca gacgttggcc                                                   20


<210>  2186
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2186
cctggcagta ggcacccagc                                                   20


<210>  2187
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2187
tacttacaag ctaaggatca                                                   20


<210>  2188
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2188
aagttcttaa agttcctggt                                                   20


<210>  2189
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2189
aagatagaaa attaattatt                                                   20


<210>  2190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2190
aaagatgaca aaggaaatcc                                                   20


<210>  2191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2191
tggttaaact gctctgatca                                                   20


<210>  2192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2192
ctctcagaat tggtcaaaga                                                   20


<210>  2193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2193
gagcaaattt ggataaagga                                                   20


<210>  2194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2194
gaagaaaaga actgtgaatt                                                   20


<210>  2195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2195
cctctcagta ttcttggacc                                                   20


<210>  2196
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2196
cagcagaaga aaaggtgaga                                                   20


<210>  2197
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2197
gctgatgaga agggtccctc                                                   20


<210>  2198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2198
ctagggccgg cagcagtgac                                                   20


<210>  2199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2199
atgggctaag cgctcagttt                                                   20


<210>  2200
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2200
ggtcagggtg gcttatgcaa                                                   20


<210>  2201
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2201
tctgagtttc gagtcagggg                                                   20


<210>  2202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2202
gcactaagag cactgcgaac                                                   20


<210>  2203
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2203
catggaccca tgtgctggtg                                                   20


<210>  2204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2204
cggaggcggc ccacgatgga                                                   20


<210>  2205
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2205
tggccgtcac attgttgtcc                                                   20


<210>  2206
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2206
ggtccagacc cactggctgc                                                   20


<210>  2207
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2207
cctccaggat tccagaacct                                                   20


<210>  2208
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2208
gaagggcaca tgccagacac                                                   20


<210>  2209
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2209
acctgatgtg gttggtgctg                                                   20


<210>  2210
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2210
ttgctaaggg gtatctacag                                                   20


<210>  2211
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2211
ccctgattca agcgcaccct                                                   20


<210>  2212
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2212
gctagtcctc agacttcacg                                                   20


<210>  2213
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2213
gaacatggtc gctctggaca                                                   20


<210>  2214
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2214
ggatcaagcc ttcacgttgc                                                   20


<210>  2215
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2215
ctgggacact tcttcttctc                                                   20


<210>  2216
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2216
gctgcagccg ggagagttcg                                                   20


<210>  2217
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2217
gcgcgagcag cgcaatggtc                                                   20


<210>  2218
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2218
aatcagttga agcgccattc                                                   20


<210>  2219
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2219
ctacccgtcc gtgaacttcc                                                   20


<210>  2220
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2220
ctgaggggcc atggatgcta                                                   20


<210>  2221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2221
ccggatgaga aaggtgaagg                                                   20


<210>  2222
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2222
tggggaccca gcgcacgcag                                                   20


<210>  2223
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2223
gccatgcgcg cctggagagc                                                   20


<210>  2224
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2224
aagctcactc catgcagtac                                                   20


<210>  2225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2225
ctgtggcaga gggacaggac                                                   20


<210>  2226
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2226
gagcctcagg tggcagcccc                                                   20


<210>  2227
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2227
caggctagcc tggtgggccc                                                   20


<210>  2228
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2228
ctcgaggcac tctggcagca                                                   20


<210>  2229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2229
ccgcccacac ctgcagggag                                                   20


<210>  2230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2230
cagtatgtgc aggtaccctg                                                   20


<210>  2231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2231
gcatggtgaa cacgtcctgc                                                   20


<210>  2232
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2232
ggacatgagt ttcagcacgc                                                   20


<210>  2233
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2233
agagatgaaa ctggccctcc                                                   20


<210>  2234
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2234
ggcttagacc tgggaggcgg                                                   20


<210>  2235
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2235
aagctacact ccagctggat                                                   20


<210>  2236
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2236
cctgaccctg ttggtgctgc                                                   20


<210>  2237
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2237
cctgtcgatg taaaccacga                                                   20


<210>  2238
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2238
tcgctattca atttcctgtt                                                   20


<210>  2239
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2239
aatagtgccc ctggacaaag                                                   20


<210>  2240
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2240
cctaggagcc cgggaatacc                                                   20


<210>  2241
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2241
atttgcagtg gacgatggaa                                                   20


<210>  2242
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2242
gcggctaggg cttggtctgg                                                   20


<210>  2243
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2243
ctgggcaggg atggctgcct                                                   20


<210>  2244
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2244
tcttcacagg gaagttttgg                                                   20


<210>  2245
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2245
tccagcctag gccttgaacc                                                   20


<210>  2246
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2246
atcctacagg tgcagcacca                                                   20


<210>  2247
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2247
cacctgagaa gtcggctgag                                                   20


<210>  2248
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2248
tgcggcagaa ggctgatagg                                                   20


<210>  2249
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2249
cccgatcccc ctggtacatc                                                   20


<210>  2250
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2250
ccgtgacagt gatggaagtg                                                   20


<210>  2251
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2251
cccagtcctg ctggaagtcg                                                   20


<210>  2252
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2252
aatgcgccac aaaaccctgc                                                   20


<210>  2253
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2253
cactcaatcc caggggctct                                                   20


<210>  2254
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2254
tgtacgaaaa atgtgagtta                                                   20


<210>  2255
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2255
cgctatccag caataccttg                                                   20


<210>  2256
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2256
agtgatgaag aaggaaagag                                                   20


<210>  2257
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2257
ccctagtggg acacctcctc                                                   20


<210>  2258
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2258
gatcctgatg tcggaggacc                                                   20


<210>  2259
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2259
ccactacaaa cttgttggtg                                                   20


<210>  2260
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2260
gtattaccgc ccccggtagt                                                   20


<210>  2261
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2261
gactatgtgc attttaggcc                                                   20


<210>  2262
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2262
ggccgcagca agtgtgaatg                                                   20


<210>  2263
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2263
ccctgaggag cctggtctca                                                   20


<210>  2264
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2264
tgtctatcct aggtgtttgt                                                   20


<210>  2265
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2265
aaagatgatg ctggccaacc                                                   20


<210>  2266
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2266
gtaagagtcc acaccagctg                                                   20


<210>  2267
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2267
gctgatcctg ctggtcccgc                                                   20


<210>  2268
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2268
gtgggtatga accactgtat                                                   20


<210>  2269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2269
caaagcattc ggtgatgaag                                                   20


<210>  2270
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2270
acctcagcta gcgagctctc                                                   20


<210>  2271
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2271
atgggaaccg ctacttcaag                                                   20


<210>  2272
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2272
gcagcacgac actgtggcca                                                   20


<210>  2273
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2273
gagtcatccc ctcttgttca                                                   20


<210>  2274
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2274
cgatgtctac tgccctctgg                                                   20


<210>  2275
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2275
gacctgcacc acaccttcat                                                   20


<210>  2276
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2276
cacccactac ctggtgttag                                                   20


<210>  2277
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2277
cgcccatgtg cactcggatg                                                   20


<210>  2278
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2278
ccctagcttc gctggtgaga                                                   20


<210>  2279
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2279
ggtggcccat gtagcctggg                                                   20


<210>  2280
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2280
ccagcaaggc ggcaaagagc                                                   20


<210>  2281
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2281
ccactttctc atgtgcaacc                                                   20


<210>  2282
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2282
tgggccactt gacgcggtcc                                                   20


<210>  2283
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2283
ggaacgaagc cgcccaggaa                                                   20


<210>  2284
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2284
tcgagttcct ggaaagataa                                                   20


<210>  2285
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2285
agctctagtc catgatgagg                                                   20


<210>  2286
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2286
gccattcgct aaaccccaac                                                   20


<210>  2287
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2287
agcccgccac tgaggaggcc                                                   20


<210>  2288
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2288
agtaggaaac caggagctaa                                                   20


<210>  2289
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2289
ttggtcctat cggttcatga                                                   20


<210>  2290
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2290
cgagcaggtg cacaaggtca                                                   20


<210>  2291
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2291
gtgtaatgga gggccagggg                                                   20


<210>  2292
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2292
cagctagtct cctgagaaga                                                   20


<210>  2293
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2293
cagcccctac ttcctgcata                                                   20


<210>  2294
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2294
ggggactggt ttgccatccg                                                   20


<210>  2295
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2295
aatgactctc ctggtgcccc                                                   20


<210>  2296
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2296
ttggcagatg gcaccagtgc                                                   20


<210>  2297
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2297
cctgaacccc gcggtattcc                                                   20


<210>  2298
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2298
tactgctagg gtgggcggac                                                   20


<210>  2299
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2299
acgagtttct ctgggggcac                                                   20


<210>  2300
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2300
gcctgctagg ccacttcacg                                                   20


<210>  2301
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2301
gtgtgagaac gacctctctc                                                   20


<210>  2302
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2302
gctctactcg ccgccgaggt                                                   20


<210>  2303
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2303
cctgatcctg ctggagccac                                                   20


<210>  2304
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2304
gctacttgcg cttctcgtgc                                                   20


<210>  2305
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2305
gtcggaccaa gtggcgcaag                                                   20


<210>  2306
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2306
ctcagaagtc agatgcacca                                                   20


<210>  2307
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2307
cctcattctc cattcttacc                                                   20


<210>  2308
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2308
ggatgctggt gaagccacct                                                   20


<210>  2309
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2309
ctacttctca gtcaagagct                                                   20


<210>  2310
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2310
aaagatccag ctgggatacc                                                   20


<210>  2311
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2311
tcctgagttg ctgtccccca                                                   20


<210>  2312
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2312
cctagagtca acggtgctcc                                                   20


<210>  2313
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2313
gttagtcccc ctggcttcgc                                                   20


<210>  2314
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2314
agtgtgagcc gccatcggcg                                                   20


<210>  2315
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2315
ccactagaaa ctttccccca                                                   20


<210>  2316
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2316
tgcgcaggcg ccgctgctgc                                                   20


<210>  2317
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2317
tctgcaaaca ccttttctat                                                   20


<210>  2318
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2318
ggtttaaatg gtttccccag                                                   20


<210>  2319
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2319
ccccagagac gatgtaagtg                                                   20


<210>  2320
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2320
caggatcccc ctggtcctcc                                                   20


<210>  2321
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2321
tccccactcc attgtggccc                                                   20


<210>  2322
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2322
tggcgtatgg aaaaagcaac                                                   20


<210>  2323
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2323
ctcagctgga gagaagtcga                                                   20


<210>  2324
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2324
cacctagctc ttgaatgaca                                                   20


<210>  2325
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2325
cgtagtcttc ctggagctga                                                   20


<210>  2326
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2326
ggacgtcccg ccggggtcgc                                                   20


<210>  2327
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2327
cagggctaca gcagcagcat                                                   20


<210>  2328
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2328
gcctcccagc aggtgcgatg                                                   20


<210>  2329
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2329
tcttactcga gatgtgatga                                                   20


<210>  2330
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2330
gatgaccctc ctggactccc                                                   20


<210>  2331
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2331
actggcctag agcggccagg                                                   20


<210>  2332
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2332
acctcaaagg gagaagccaa                                                   20


<210>  2333
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2333
tcaggctaag gggacagatg                                                   20


<210>  2334
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2334
cagcacctcc cagttctgag                                                   20


<210>  2335
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2335
gctgaggctc ccggcctccc                                                   20


<210>  2336
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2336
gactcttatg caggttcggg                                                   20


<210>  2337
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2337
cctatgcagc cagcacacct                                                   20


<210>  2338
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2338
ggatcagctt cattgtgctg                                                   20


<210>  2339
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2339
tcttaagggc tggatggtgg                                                   20


<210>  2340
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2340
catctatgtg gcctgtctcc                                                   20


<210>  2341
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2341
ccatcagcct gggcaacgtc                                                   20


<210>  2342
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2342
agtccagcca gaaggcgtgc                                                   20


<210>  2343
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2343
aaggatgatg ccggtgcacc                                                   20


<210>  2344
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2344
gctaggggga actgagcacc                                                   20


<210>  2345
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2345
tcctttatgg agttttaaat                                                   20


<210>  2346
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2346
tccaactaca gcgtctcctt                                                   20


<210>  2347
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2347
atgccctagg gcccctgggg                                                   20


<210>  2348
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2348
ggactatgaa ataatgctgt                                                   20


<210>  2349
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2349
gggcctagtc ttccagggtg                                                   20


<210>  2350
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2350
ggctacgcag gggcccccgt                                                   20


<210>  2351
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2351
actgatttcc ctggtgctgc                                                   20


<210>  2352
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2352
ccccaatgac ggccagcagg                                                   20


<210>  2353
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2353
actggagccc cggaactcaa                                                   20


<210>  2354
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2354
gcatcatccc atgtctttag                                                   20


<210>  2355
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2355
cgtgagcttc ctggtgagag                                                   20


<210>  2356
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2356
gctctcagag caccgggtgc                                                   20


<210>  2357
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2357
catgcactcc aggtgggcgc                                                   20


<210>  2358
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2358
acctgaccca cctggacatt                                                   20


<210>  2359
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2359
ccagagcctc gaggtaacag                                                   20


<210>  2360
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2360
cttgaccttg aaggtcatgt                                                   20


<210>  2361
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2361
cctgatgctg ctggtactcc                                                   20


<210>  2362
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2362
tgaccacctg gcctcctacc                                                   20


<210>  2363
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2363
tgtggctgca gatggtgtgt                                                   20


<210>  2364
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2364
ggggggcaag cagctgctgc                                                   20


<210>  2365
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2365
aatctaggtc tggtctccat                                                   20


<210>  2366
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2366
actacctatt atctgagctc                                                   20


<210>  2367
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2367
ccgagagccc caggtcgaga                                                   20


<210>  2368
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2368
cttccagagg tgcttgaatc                                                   20


<210>  2369
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2369
gtggatcctg ctggcaaaca                                                   20


<210>  2370
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2370
ccgggcagat ggtctcagtg                                                   20


<210>  2371
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2371
ccaggagcct gtggggctcc                                                   20


<210>  2372
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2372
tcctagtcca aagggtgaca                                                   20


<210>  2373
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2373
gctgcaggtg accgagggct                                                   20


<210>  2374
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2374
ggagaccctc ctggagttgc                                                   20


<210>  2375
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2375
gccgatgcac ctggagctcc                                                   20


<210>  2376
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2376
catggatgct cagcgtgatg                                                   20


<210>  2377
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2377
tgggggatca cttccgcatg                                                   20


<210>  2378
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2378
gatccggaca ggggcctccc                                                   20


<210>  2379
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2379
cactcaggag aaagggtcgg                                                   20


<210>  2380
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2380
tctccctcta cacactgcct                                                   20


<210>  2381
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2381
cccaggctgg caggacacaa                                                   20


<210>  2382
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2382
agattagatg aaccgcatgg                                                   20


<210>  2383
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2383
cccaagtgcc cctggcccca                                                   20


<210>  2384
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2384
gggcccttag tgcgtcatcc                                                   20


<210>  2385
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2385
gccagccctc caggacctcc                                                   20


<210>  2386
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2386
tgctactgct gttgttgctg                                                   20


<210>  2387
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2387
cttactcgcc ggagtcccct                                                   20


<210>  2388
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2388
cttcgcttca tcctctcctc                                                   20


<210>  2389
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2389
gtcctactgg tccagggggc                                                   20


<210>  2390
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2390
tccggtagaa cagggactcc                                                   20


<210>  2391
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2391
cctgaacccc agggtcttcc                                                   20


<210>  2392
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2392
cgtcgtgcta caagccaacg                                                   20


<210>  2393
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2393
attgctggat gactggatgg                                                   20


<210>  2394
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2394
caagtactcg tgctagaact                                                   20


<210>  2395
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2395
accacctggt acttgctggc                                                   20


<210>  2396
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2396
ggcccagcct gccaagagga                                                   20


<210>  2397
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2397
gagttactgc attgctgacc                                                   20


<210>  2398
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2398
cgtctcagtc atggtacctg                                                   20


<210>  2399
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2399
agctcgtacc caaccaggtt                                                   20


<210>  2400
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2400
cttcagggag cgcttttcta                                                   20


<210>  2401
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2401
ccaccatgag gctaggagga                                                   20


<210>  2402
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2402
tcactcccca ttcaccctga                                                   20


<210>  2403
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2403
cgtgatccac caggctcaag                                                   20


<210>  2404
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2404
ccacatgtcc atcatcgtgc                                                   20


<210>  2405
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2405
ggcccccacc gcgggtaggt                                                   20


<210>  2406
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2406
ccagagcccc ccggccccaa                                                   20


<210>  2407
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2407
gacagtgctc gaggcagtga                                                   20


<210>  2408
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2408
gggctagaga cccccaaggc                                                   20


<210>  2409
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2409
gcactcaggg cgcctctgcc                                                   20


<210>  2410
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2410
tctagccctg cgtggagccc                                                   20


<210>  2411
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2411
agctctatcg ctgggcaaag                                                   20


<210>  2412
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2412
ccagagcaac caggccctcc                                                   20


<210>  2413
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2413
tcagcctagt tccaggggat                                                   20


<210>  2414
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2414
tgtacccgta aggggaagta                                                   20


<210>  2415
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2415
tctgaggagg ctgtagggtt                                                   20


<210>  2416
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2416
tcgctctaga ggtcgtggaa                                                   20


<210>  2417
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2417
gtaagtggcc tctttatatg                                                   20


<210>  2418
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2418
cactacgaaa aggcctgtgg                                                   20


<210>  2419
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2419
cgctggcaag tatggtgcgg                                                   20


<210>  2420
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2420
actttactgt tcggaactac                                                   20


<210>  2421
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2421
cactactgca tcatagatga                                                   20


<210>  2422
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2422
catccagagt gggccttgcc                                                   20


<210>  2423
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2423
aggatagtaa acttatcatc                                                   20


<210>  2424
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2424
agagctagtc acggtggaag                                                   20


<210>  2425
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2425
cctaggcgtc ctcacgactt                                                   20


<210>  2426
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2426
accaggctgc gtgagtgtga                                                   20


<210>  2427
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2427
gtgttcaatg cagatgaaat                                                   20


<210>  2428
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2428
gctcactggt ataccaaact                                                   20


<210>  2429
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2429
ctcatggtgc tctggaccga                                                   20


<210>  2430
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2430
cctagacctc caggtgtaag                                                   20


<210>  2431
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2431
cccactgcag gatgtggtgc                                                   20


<210>  2432
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2432
cggcattcag ctgactcgca                                                   20


<210>  2433
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2433
tttgctaaga ctgattactt                                                   20


<210>  2434
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2434
tcatttagaa cagtctacaa                                                   20


<210>  2435
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2435
gtccctccac cacagtggag                                                   20


<210>  2436
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2436
gcagcagggt ctcggagatc                                                   20


<210>  2437
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2437
gtggcacatg cagcacagga                                                   20


<210>  2438
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2438
gggctctagc ccacgtacgg                                                   20


<210>  2439
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2439
agaacttgcc aagtgcccgc                                                   20


<210>  2440
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2440
cctgagttcc gaggacctgc                                                   20


<210>  2441
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2441
cctccagaaa tgctggtagc                                                   20


<210>  2442
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2442
ttaattcaca attcttgatg                                                   20


<210>  2443
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2443
ctgccagggc gatgggggca                                                   20


<210>  2444
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2444
ccttagcggc cagtgggtcc                                                   20


<210>  2445
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2445
ggtaggctct ggcccacgta                                                   20


<210>  2446
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2446
tgcacttgaa ccaggggtgc                                                   20


<210>  2447
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2447
cgcctcgagc ctgctcatgg                                                   20


<210>  2448
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2448
ctccatctcg cagtagtcgc                                                   20


<210>  2449
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2449
ctggtagaca ggcctggcag                                                   20


<210>  2450
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2450
gggggatgcc cacggcacgc                                                   20


<210>  2451
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2451
agtgctgcac tgcctgggtc                                                   20


<210>  2452
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2452
ggccatgcat gtgttcagaa                                                   20


<210>  2453
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2453
ggtggactca tcctgggggg                                                   20


<210>  2454
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2454
tcaaagtgct cctggctccg                                                   20


<210>  2455
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2455
tgtctcagtt ctcactggtc                                                   20


<210>  2456
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2456
agctgactgg ctacacagcc                                                   20


<210>  2457
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2457
ccgccaccag gcgcaggtcg                                                   20


<210>  2458
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2458
ggtggtccag gagcgagcag                                                   20


<210>  2459
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2459
gtatgatgtg gtggtggcag                                                   20


<210>  2460
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2460
agcactcctc agcatctgcc                                                   20


<210>  2461
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2461
atctaggaac ctgatgacgc                                                   20


<210>  2462
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2462
cttggatggg gtccacaccg                                                   20


<210>  2463
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2463
acttgctact gctgttgtcc                                                   20


<210>  2464
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2464
agccactggg tcatggtctc                                                   20


<210>  2465
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2465
cccaatgctg cctgcattcg                                                   20


<210>  2466
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2466
acacccatcg cattggagaa                                                   20


<210>  2467
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2467
gttagtgctg ccggtgctac                                                   20


<210>  2468
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2468
gggaggctag aagccgcgcg                                                   20


<210>  2469
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2469
tgttcaaggt gaaccattaa                                                   20


<210>  2470
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2470
ctgcaggcct cgtctggggg                                                   20


<210>  2471
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2471
tggctaggac tgagagacca                                                   20


<210>  2472
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2472
tcctgctcag tccgccttcc                                                   20


<210>  2473
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2473
tccctatggg gggccactgg                                                   20


<210>  2474
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2474
gcggctgcta ccctagacgc                                                   20


<210>  2475
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2475
agcctaccat tcatggaatt                                                   20


<210>  2476
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2476
acatatcctt ggccctgaat                                                   20


<210>  2477
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2477
cccagcctcc ctggaccccg                                                   20


<210>  2478
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2478
cgtggaccgt ggtacctggg                                                   20


<210>  2479
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2479
cagctacagc caccttagtt                                                   20


<210>  2480
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2480
cgatgagacc cagacaaggc                                                   20


<210>  2481
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2481
ctagttctcg aggcccgctg                                                   20


<210>  2482
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2482
agctgctata aagagcccat                                                   20


<210>  2483
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2483
tctcttagcg cacaaagccc                                                   20


<210>  2484
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2484
ctggagccgg cagcagtgac                                                   20


<210>  2485
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2485
agtgaacctc ctggcaaaga                                                   20


<210>  2486
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2486
cccagacgtg cctggaccca                                                   20


<210>  2487
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2487
cctgttagct cggaatggct                                                   20


<210>  2488
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2488
accgagctgc gtgagtgtga                                                   20


<210>  2489
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2489
aggccctcaa ggcgagctgc                                                   20


<210>  2490
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2490
ttggtagcaa cagacccgtc                                                   20


<210>  2491
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2491
gtctatgtga cagatgcctc                                                   20


<210>  2492
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2492
atgtctcacg gtaccttgtc                                                   20


<210>  2493
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2493
ggctctaccg gactgcatcc                                                   20


<210>  2494
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2494
tgtatggacc tctttgcccc                                                   20


<210>  2495
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2495
cttcagggag gtgaaccagc                                                   20


<210>  2496
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2496
ccccagaccc cctggcccca                                                   20


<210>  2497
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2497
gacgcagatc tggacaccag                                                   20


<210>  2498
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2498
agcctacctc tgggcctcct                                                   20


<210>  2499
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2499
gctagtcctc ctgggccacc                                                   20


<210>  2500
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2500
cctagcgcca gcagatccaa                                                   20


<210>  2501
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2501
cgtgaagctg ctggcatcaa                                                   20


<210>  2502
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2502
ccggcaagcc aacaccttct                                                   20


<210>  2503
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2503
gccaggtcag cgaaggtcag                                                   20


<210>  2504
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2504
cctgctacac cagggcctgg                                                   20


<210>  2505
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2505
gctcctcagg ggcgctcccc                                                   20


<210>  2506
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2506
gcaaccactg cctgaaggaa                                                   20


<210>  2507
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2507
cctcaaggcc ctgggggacc                                                   20


<210>  2508
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2508
ctcctagaac ccacccaaaa                                                   20


<210>  2509
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2509
tggctacagc tgcagagagc                                                   20


<210>  2510
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2510
gggctacgcg cacgacttga                                                   20


<210>  2511
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2511
caaggtctat gtcttttcct                                                   20


<210>  2512
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2512
cctagtccag ctggctccaa                                                   20


<210>  2513
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2513
ctgggagaat ggccaccact                                                   20


<210>  2514
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2514
agagaagctg ctggagaacc                                                   20


<210>  2515
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2515
cctgacgctc ctggtcatcc                                                   20


<210>  2516
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2516
aatgccactg tgaccgcaag                                                   20


<210>  2517
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2517
gctagcccac cttgctgctc                                                   20


<210>  2518
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2518
ggccgtgtag aatgcccagg                                                   20


<210>  2519
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2519
cgtagtgcaa gtggccctgc                                                   20


<210>  2520
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2520
ctcctgatgc attgaggcac                                                   20


<210>  2521
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2521
ctcgtgctac agcccccctg                                                   20


<210>  2522
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2522
tctagggagc tatgccagga                                                   20


<210>  2523
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2523
ccggctgcag gataggcagg                                                   20


<210>  2524
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2524
ttcacctagt ccagatgccc                                                   20


<210>  2525
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2525
ctcagttccg gatcaggatc                                                   20


<210>  2526
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2526
tgctcactga tagaaagctt                                                   20


<210>  2527
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2527
gccagggagc ctggaaagcc                                                   20


<210>  2528
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2528
tttccccaga ttccctggac                                                   20


<210>  2529
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2529
tccacttcac ccccggcttg                                                   20


<210>  2530
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2530
gtagatgccc ctggtcctgc                                                   20


<210>  2531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2531
tcctcagtga gatcattgaa                                                   20


<210>  2532
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2532
tacctatgca gaacccaaag                                                   20


<210>  2533
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2533
agagggggta gcacatgggc                                                   20


<210>  2534
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2534
tttgctactg acacataaaa                                                   20


<210>  2535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2535
ccagacttcc caggtgcccc                                                   20


<210>  2536
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2536
cacctagctc gtctccgtct                                                   20


<210>  2537
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2537
gctagttgga gctgacgctt                                                   20


<210>  2538
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2538
acctgaccgt gaacccacag                                                   20


<210>  2539
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2539
ccaaggcctc ccggtctccc                                                   20


<210>  2540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2540
ccggcaggtc tacattgagc                                                   20


<210>  2541
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2541
cggggtatgg tggagtactt                                                   20


<210>  2542
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2542
ggtctgatct ctgatccagc                                                   20


<210>  2543
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2543
aatgaattgc aaggtctgcc                                                   20


<210>  2544
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2544
tactagggag gctctgggcc                                                   20


<210>  2545
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2545
accctactgt gccagctggg                                                   20


<210>  2546
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2546
cgccagtccc cgtggtgaag                                                   20


<210>  2547
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2547
tcccacgggc gcccgtgcgc                                                   20


<210>  2548
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2548
caagtagctg gccaacttct                                                   20


<210>  2549
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2549
ggcttacgct tccagagctt                                                   20


<210>  2550
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2550
gaactacctc ttgagtcttt                                                   20


<210>  2551
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2551
cactacaggc ccggcacgtc                                                   20


<210>  2552
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2552
tccccagccg cctgcaagga                                                   20


<210>  2553
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2553
agaagtgaac gtggtctacc                                                   20


<210>  2554
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2554
tttggagagc cactccaaga                                                   20


<210>  2555
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2555
cctactcccg gatgttcttg                                                   20


<210>  2556
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2556
gccccactca cacctgagag                                                   20


<210>  2557
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2557
gctgatcccc ctggtcccga                                                   20


<210>  2558
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2558
gtcaggccag tgctcgccac                                                   20


<210>  2559
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2559
tggacagctg gtgggtcatc                                                   20


<210>  2560
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2560
gactaggctc ccagggcaca                                                   20


<210>  2561
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2561
cgtagtgagg tcggtcctgc                                                   20


<210>  2562
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2562
atcatgggcc gcgtgtggat                                                   20


<210>  2563
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2563
ggggccccat gagggagaca                                                   20


<210>  2564
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2564
gcccagcctc ccgggtcccc                                                   20


<210>  2565
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2565
tcctagggaa gctgacaaag                                                   20


<210>  2566
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2566
gtatcggggg cggcccacga                                                   20


<210>  2567
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2567
cctaggcaat gatggcaatg                                                   20


<210>  2568
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2568
ggcatggctg cttggtctcc                                                   20


<210>  2569
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2569
gtgtctactg tctaagtgct                                                   20


<210>  2570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2570
cgcaaggtcc tcttcaccac                                                   20


<210>  2571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2571
ggggcaagcg gctgcgcgcg                                                   20


<210>  2572
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2572
agaggcatgt ggccagcagc                                                   20


<210>  2573
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2573
ctgctagctc aggctcttga                                                   20


<210>  2574
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2574
ggtgccaggc ctccgtggtg                                                   20


<210>  2575
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2575
cacccactgc atcacaccca                                                   20


<210>  2576
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2576
aatagcccaa agaatctcaa                                                   20


<210>  2577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2577
tactaggttg accctaacca                                                   20


<210>  2578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2578
ccactatcag tgggtagatg                                                   20


<210>  2579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2579
tgccataagc cttcacctta                                                   20


<210>  2580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2580
ccagacccac ctggtcctgt                                                   20


<210>  2581
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2581
cctagtcccc ctggccctcc                                                   20


<210>  2582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2582
ggaccacttc ctcattcatc                                                   20


<210>  2583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2583
cctgattctc gtggtcttcc                                                   20


<210>  2584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2584
tccgttacct cagcagccgc                                                   20


<210>  2585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2585
gctatgactc ttgagacttg                                                   20


<210>  2586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2586
tgatcctgcc ggaggcgtag                                                   20


<210>  2587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2587
caaccccacc agctgcttgt                                                   20


<210>  2588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2588
acgatatgtc gccagatcaa                                                   20


<210>  2589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2589
ccttattcca atcccaggta                                                   20


<210>  2590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2590
catgcagcct ctgtccaaca                                                   20


<210>  2591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2591
gctagttcac gcccgcgccc                                                   20


<210>  2592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2592
ccagaccctc ctggacctcc                                                   20


<210>  2593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2593
ctacctgcac atctgggtgc                                                   20


<210>  2594
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2594
ctgctagggc atcatggcag                                                   20


<210>  2595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2595
tccttctgag ctcgctgctg                                                   20


<210>  2596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2596
aaggcagcgt ggcactagga                                                   20


<210>  2597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2597
acccatctcc actggggttt                                                   20


<210>  2598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2598
caagacccac gtggtgacaa                                                   20


<210>  2599
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2599
aaacccagcc ccagctccca                                                   20


<210>  2600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2600
ccttcaccct gacgctctcc                                                   20


<210>  2601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2601
tgatcactgt gaggctccat                                                   20


<210>  2602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2602
aggttatcca caggtccttg                                                   20


<210>  2603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2603
ggtgcacgca aacaccatct                                                   20


<210>  2604
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2604
cgcagccatg gagggtgatc                                                   20


<210>  2605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2605
ctcccagcag cccctgggaa                                                   20


<210>  2606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2606
tgctaggcat ggactggggc                                                   20


<210>  2607
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2607
tcttagaagt cctggtccaa                                                   20


<210>  2608
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2608
ctctagggag gagaaatccc                                                   20


<210>  2609
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2609
tcttatgcaa tgaacatcaa                                                   20


<210>  2610
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2610
catagttgca gcccaagtca                                                   20


<210>  2611
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2611
ccctcaagga cgccgacctg                                                   20


<210>  2612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2612
tctaggtcat tccaaccccc                                                   20


<210>  2613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2613
ttcctaggag agatggatgg                                                   20


<210>  2614
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2614
gcaagtgatg gcgacctagt                                                   20


<210>  2615
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2615
ggcctagctg ccctgtgagc                                                   20


<210>  2616
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2616
ccgggaccag cctgcaggaa                                                   20


<210>  2617
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2617
caactataat ccagctccag                                                   20


<210>  2618
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2618
ctgaccgccc tcggcgtccg                                                   20


<210>  2619
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2619
gtcgttccac agccgtctgg                                                   20


<210>  2620
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2620
agactagaaa cgctcaaata                                                   20


<210>  2621
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2621
cgctgatgca ttcatccagg                                                   20


<210>  2622
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2622
catagcgatc cgcgagagcg                                                   20


<210>  2623
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2623
cctggtcagc caggggtacc                                                   20


<210>  2624
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2624
cgtactcgat ggggtacttc                                                   20


<210>  2625
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2625
tcaggctagg gggacaggtg                                                   20


<210>  2626
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2626
ctattgcaat cccttaagca                                                   20


<210>  2627
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2627
agccggactt acagtcacag                                                   20


<210>  2628
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2628
gcagaggccc caggacttag                                                   20


<210>  2629
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2629
cttacaggcc agcctgccta                                                   20


<210>  2630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2630
gaatgattct tcaccaaggt                                                   20


<210>  2631
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2631
ggtggcctat ggagttgcta                                                   20


<210>  2632
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2632
aaagatgaag gaggccctcc                                                   20


<210>  2633
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2633
ccgctacagc ttgtcctgag                                                   20


<210>  2634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2634
ccactacctg ctggtgaccc                                                   20


<210>  2635
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2635
gccgcaccac tacgacgacc                                                   20


<210>  2636
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2636
cttacctgcc tgacacttgc                                                   20


<210>  2637
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2637
cacgtagctt gcgcggcgcg                                                   20


<210>  2638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2638
ggttaggcaa tactgccttt                                                   20


<210>  2639
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2639
tctggaaccc aggggatcac                                                   20


<210>  2640
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2640
cctgatgccc ctggtgaaaa                                                   20


<210>  2641
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2641
caccagaagc actactgacc                                                   20


<210>  2642
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2642
gttaggggcc cagaaggttc                                                   20


<210>  2643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2643
gtgagtcttc caggcctctc                                                   20


<210>  2644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2644
ggcatctgga ctctgtcacc                                                   20


<210>  2645
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2645
gtcagtcctg ctggccccaa                                                   20


<210>  2646
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2646
ggagctaaac aacaaatgtt                                                   20


<210>  2647
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2647
gcctgaccct cggccatcgc                                                   20


<210>  2648
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2648
tgttttattc cttgcccgtc                                                   20


<210>  2649
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2649
ctcacatcca gattcaccag                                                   20


<210>  2650
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2650
ctctcaggag atctgaacga                                                   20


<210>  2651
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2651
gaggacctct ttttcaccaa                                                   20


<210>  2652
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2652
cttgaggcgg ccgggcccgg                                                   20


<210>  2653
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2653
gcaggtaggc gatggcctcg                                                   20


<210>  2654
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2654
gtctcatgcc tgctcatggt                                                   20


<210>  2655
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2655
gtcctagcca taccacctgc                                                   20


<210>  2656
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2656
cctgatgtca aaggagaagc                                                   20


<210>  2657
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2657
gcgctccagg tgtgccgccg                                                   20


<210>  2658
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2658
ggcgccctta tgcattctcg                                                   20


<210>  2659
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2659
aaactacagc agcagcctgc                                                   20


<210>  2660
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2660
gtgttcatgc agctgaagta                                                   20


<210>  2661
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2661
cagctagatt acatgcttcc                                                   20


<210>  2662
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2662
tccatacgtg gcaggcgtgg                                                   20


<210>  2663
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2663
ggcagaaagg ccaggagaga                                                   20


<210>  2664
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2664
agaagggctc ctggtgagcg                                                   20


<210>  2665
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2665
catgcagttg accgtataga                                                   20


<210>  2666
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2666
acactagaag actgtcagca                                                   20


<210>  2667
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2667
ggactagaca tcttttaacc                                                   20


<210>  2668
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2668
gaatatcccc ccaacttcac                                                   20


<210>  2669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2669
gtccacgggc tacaccaaac                                                   20


<210>  2670
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2670
actgacgtga ttggacttac                                                   20


<210>  2671
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2671
ttcttgatgg aaagatggga                                                   20


<210>  2672
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2672
ggttgacctt gggattgagg                                                   20


<210>  2673
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2673
ctactgcagc ttctgccagg                                                   20


<210>  2674
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2674
gccggagctc ccaggagaga                                                   20


<210>  2675
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2675
cggcttccac ctcaggctcg                                                   20


<210>  2676
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2676
tgcagttggc gtggctgagc                                                   20


<210>  2677
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2677
cacccacatc cccctgcaga                                                   20


<210>  2678
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2678
tcctcagggt ccctcctggc                                                   20


<210>  2679
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2679
gcccctgatc cttgctgtgg                                                   20


<210>  2680
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2680
agcccctcta gccatgccat                                                   20


<210>  2681
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2681
ccatgaccag tgcagctgtg                                                   20


<210>  2682
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2682
agagctagca ttcagacctc                                                   20


<210>  2683
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2683
gctgcagcaa caacggtttt                                                   20


<210>  2684
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2684
gaccctactg ctgttgctgc                                                   20


<210>  2685
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2685
cctgatcccc aaggtgtcaa                                                   20


<210>  2686
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2686
caaccgcaag aagatgaccc                                                   20


<210>  2687
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2687
tgcccacaac ctcctgacag                                                   20


<210>  2688
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2688
tgtgaccagc tttcaggcag                                                   20


<210>  2689
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2689
cttagtctcc acctggatgc                                                   20


<210>  2690
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2690
catctaacct ggcagctgga                                                   20


<210>  2691
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2691
gaagaggctg atgatgctgg                                                   20


<210>  2692
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2692
tcacttccag aaaggcagca                                                   20


<210>  2693
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2693
acaccccggc ctaagcagcg                                                   20


<210>  2694
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2694
cagccactgc ttctggcctc                                                   20


<210>  2695
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2695
aatccatgtc tgggcaggga                                                   20


<210>  2696
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2696
gatcagaccc cctgggcttc                                                   20


<210>  2697
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2697
cgaggacccc agcgaccctc                                                   20


<210>  2698
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2698
atgcaagtga aacggctacg                                                   20


<210>  2699
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2699
gaccgaggcg tgtctccagc                                                   20


<210>  2700
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2700
acgcctgtag tatgttatgc                                                   20


<210>  2701
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2701
gtggcagcta actttccttc                                                   20


<210>  2702
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2702
cctaggcagg gggtggctcc                                                   20


<210>  2703
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2703
gctcaccttc gggatcagct                                                   20


<210>  2704
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2704
ccgtagtcct cctggtgctg                                                   20


<210>  2705
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2705
tgaacctact catccacatt                                                   20


<210>  2706
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2706
cgggatcttg caggaccacc                                                   20


<210>  2707
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2707
ggccatgcgg gaaagagcag                                                   20


<210>  2708
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2708
cctccatgat gttgatgcca                                                   20


<210>  2709
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2709
tcaccacagt caccctggcg                                                   20


<210>  2710
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2710
cacctgccag gccctgggcg                                                   20


<210>  2711
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2711
ccagatctcc ctggaactcc                                                   20


<210>  2712
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2712
cagggaaccc aagggctaca                                                   20


<210>  2713
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2713
cggctagaag ttcgagaagc                                                   20


<210>  2714
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2714
tttcctagat cacctccaac                                                   20


<210>  2715
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2715
tcctactctg ggtcctcctc                                                   20


<210>  2716
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2716
tcagcctgct ggcgggtacg                                                   20


<210>  2717
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2717
gggggatcag ataggcctgg                                                   20


<210>  2718
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2718
gaggcaaagc acctctcgga                                                   20


<210>  2719
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2719
tatggagcgc tcagcagctg                                                   20


<210>  2720
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2720
caagtcctca gaaatccatc                                                   20


<210>  2721
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2721
tgatgaaaac aatggtgctc                                                   20


<210>  2722
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2722
agcagcctcc tgctctacaa                                                   20


<210>  2723
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2723
gggctcagtg gcccacggtc                                                   20


<210>  2724
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2724
cacaggcagc ttcaggaggc                                                   20


<210>  2725
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2725
cctgaatcag atggtcttcc                                                   20


<210>  2726
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2726
tggttcttga tgtccttagt                                                   20


<210>  2727
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2727
agagtatgct cctttctgcc                                                   20


<210>  2728
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2728
agctgcacag caggggcagg                                                   20


<210>  2729
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2729
cgactcagcc agcagcacca                                                   20


<210>  2730
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2730
taggagaagc cctggccctc                                                   20


<210>  2731
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2731
tttcactagg gttcacttga                                                   20


<210>  2732
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2732
caggtacacc cagagaggca                                                   20


<210>  2733
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2733
tttcactgcg ctcatcatga                                                   20


<210>  2734
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2734
aaactagagg gctccatgat                                                   20


<210>  2735
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2735
cggtagcgct gtcagcggcg                                                   20


<210>  2736
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2736
tgttcctagc cacctggggc                                                   20


<210>  2737
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2737
gctctgctag ggggcgctgg                                                   20


<210>  2738
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2738
ctggagagtg gtctctgtgc                                                   20


<210>  2739
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2739
atggcatggc gaaaaagtgg                                                   20


<210>  2740
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2740
tgtgctatga agggggtgtg                                                   20


<210>  2741
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2741
cagcagccgg gatgccggcg                                                   20


<210>  2742
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2742
ggagcatgag gtaatcagcc                                                   20


<210>  2743
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2743
cgcccaccgc agcagcttca                                                   20


<210>  2744
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2744
acactcatgt atcttcattc                                                   20


<210>  2745
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2745
cacagccagg gctggaggtg                                                   20


<210>  2746
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2746
ctgtatggag gctccatcat                                                   20


<210>  2747
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2747
gcagtacctg gccatgggct                                                   20


<210>  2748
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2748
ccccaccccg gcaaggctgg                                                   20


<210>  2749
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2749
tagccctatg acttatcctg                                                   20


<210>  2750
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2750
tgagctgcta gtcccagctg                                                   20


<210>  2751
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2751
cgttgagcac ggtcccaaag                                                   20


<210>  2752
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2752
atcgacaggc gcattgtgga                                                   20


<210>  2753
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2753
cacctcagtc tgcagctaca                                                   20


<210>  2754
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2754
cctgatcctc ttggcattgc                                                   20


<210>  2755
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2755
tgctatttcc ggacctaaca                                                   20


<210>  2756
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2756
actccccaca gaggtccagc                                                   20


<210>  2757
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2757
gacccctagc tgccttggat                                                   20


<210>  2758
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2758
atccattccc gtacttcctt                                                   20


<210>  2759
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2759
tgccttgacc agtgccccag                                                   20


<210>  2760
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2760
tggcttaagg gctgatgtgt                                                   20


<210>  2761
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2761
gaggctgagc agccacagga                                                   20


<210>  2762
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2762
cctgaatcca aaggagagca                                                   20


<210>  2763
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2763
gatctacccg ccctgaggcc                                                   20


<210>  2764
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2764
gccaggttgc caggactgcg                                                   20


<210>  2765
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2765
tgcccaccga ctccatacct                                                   20


<210>  2766
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2766
gatcgcagcc cgccaggtcc                                                   20


<210>  2767
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2767
gtccagggag gctgcgcctc                                                   20


<210>  2768
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2768
gcgcatggcc gtggaggagg                                                   20


<210>  2769
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2769
cctgattccc tgaggaccag                                                   20


<210>  2770
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2770
cactcacttc ttcagggcag                                                   20


<210>  2771
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2771
cccagttctc ctggccagaa                                                   20


<210>  2772
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2772
ctggatcatc ttctcgcggt                                                   20


<210>  2773
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2773
gatatggggc ccaggatgac                                                   20


<210>  2774
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2774
gcacgtggcc tcgtagccca                                                   20


<210>  2775
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2775
tagccaggag cacgatctgt                                                   20


<210>  2776
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2776
tccaccgacc acctccagcc                                                   20


<210>  2777
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2777
tatctaagcc cggtagccac                                                   20


<210>  2778
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2778
aaagagccta agggtgaaaa                                                   20


<210>  2779
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2779
tgtgcagtcg aacagcatga                                                   20


<210>  2780
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2780
cgtctacaag tgagcggccc                                                   20


<210>  2781
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2781
agccctactg caccagggcc                                                   20


<210>  2782
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2782
taggccctag ggtggctctg                                                   20


<210>  2783
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2783
cagcgtgaag gctactgctc                                                   20


<210>  2784
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2784
cctgagccac ctggtgctgc                                                   20


<210>  2785
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2785
cgtgatttcc ctggagacgc                                                   20


<210>  2786
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2786
atccatgccc gtcaggtagt                                                   20


<210>  2787
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2787
gtttcatgcc tgctcatggc                                                   20


<210>  2788
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2788
tgcgctagac cagggggttc                                                   20


<210>  2789
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2789
gagttaggtg ccaaaacttg                                                   20


<210>  2790
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2790
cgtagtgacc aaggtccagt                                                   20


<210>  2791
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2791
tctagctctc agcctgctac                                                   20


<210>  2792
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2792
tcgctaaaga cctatttcta                                                   20


<210>  2793
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2793
cactcagaac cttaggcatt                                                   20


<210>  2794
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2794
cctgatgctg ctggacggac                                                   20


<210>  2795
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2795
agcctaggcc aggagaccta                                                   20


<210>  2796
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2796
gagagtaggc aaatgacctg                                                   20


<210>  2797
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2797
cgtagtcctc gtggtgacca                                                   20


<210>  2798
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2798
ccagcctagg tgaacatgta                                                   20


<210>  2799
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2799
ttcatagacg gccacctaga                                                   20


<210>  2800
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2800
agcttctatg tgtcctcttt                                                   20


<210>  2801
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2801
gaggctcact cctctgtgat                                                   20


<210>  2802
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2802
cctgatctgc aaggaatgcc                                                   20


<210>  2803
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2803
cctaggggga ggacgaggag                                                   20


<210>  2804
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2804
cggaatgctg agcggtgtgg                                                   20


<210>  2805
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2805
cttccctatc tctacagccc                                                   20


<210>  2806
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2806
gtccagtccc caggaggaaa                                                   20


<210>  2807
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2807
cagccaccag tcataggggg                                                   20


<210>  2808
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2808
tggtgttagg taaatccggg                                                   20


<210>  2809
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2809
ctccagagtg cataaatcag                                                   20


<210>  2810
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2810
aggttagccg tcagcaccct                                                   20


<210>  2811
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2811
tgaggctgcg cgggcccttg                                                   20


<210>  2812
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2812
gatctaggca tcaataatca                                                   20


<210>  2813
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2813
acgggcccag gggcgcggac                                                   20


<210>  2814
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2814
aaagtgtaga tctatcccga                                                   20


<210>  2815
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2815
cagatgctgg gagtcctgcc                                                   20


<210>  2816
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2816
ctctcagctc tgccttggtc                                                   20


<210>  2817
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2817
tgacctcacc tgggtgttcg                                                   20


<210>  2818
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2818
ggcctattcc acctgtcccc                                                   20


<210>  2819
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2819
gtatcagaca gatgaagtag                                                   20


<210>  2820
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2820
ggagcacctg gccaagctgc                                                   20


<210>  2821
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2821
cgctcgtact ccgtgcccga                                                   20


<210>  2822
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2822
ctcacttgcc ggccttgatc                                                   20


<210>  2823
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2823
tggctccagt atcgtcaaca                                                   20


<210>  2824
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2824
cccagacctg ccaggctgca                                                   20


<210>  2825
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2825
aaggcccagc tcaacagtca                                                   20


<210>  2826
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2826
actagtccta ttggtcctcc                                                   20


<210>  2827
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2827
ggatccgcac gggccgggtc                                                   20


<210>  2828
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2828
ctggcagcag gtatcacaca                                                   20


<210>  2829
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2829
ccgggacgac cccggctttg                                                   20


<210>  2830
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2830
agctgacccg cagggtgatc                                                   20


<210>  2831
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2831
actttacaga tcagaggtgg                                                   20


<210>  2832
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2832
cctgactgga cagccaccac                                                   20


<210>  2833
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2833
aagaggcatc catttcaggt                                                   20


<210>  2834
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2834
catagtgagt ttggtctccc                                                   20


<210>  2835
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2835
cagagctaac acagtctgaa                                                   20


<210>  2836
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2836
agcatgagct ctgccttctc                                                   20


<210>  2837
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2837
caaccaccgg gacgtacggc                                                   20


<210>  2838
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2838
aatgcagtcc ccaaggaggt                                                   20


<210>  2839
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2839
tgtttagctg gaaacagacc                                                   20


<210>  2840
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2840
ctctgcagga aaaatggtgg                                                   20


<210>  2841
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2841
aatgaggaag ctggatctgc                                                   20


<210>  2842
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2842
tcctcagtct tcctcattca                                                   20


<210>  2843
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2843
ggccggtcag tcagtcttac                                                   20


<210>  2844
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2844
ggtaggctag ctcgccgctt                                                   20


<210>  2845
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2845
ggctactgct gctgcggcgg                                                   20


<210>  2846
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2846
aaacaagggg atgcctgtga                                                   20


<210>  2847
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2847
gtgaccatgg cctgcgagga                                                   20


<210>  2848
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2848
gtctcaggcg tccctccaag                                                   20


<210>  2849
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2849
cgactgtgcg tggcgagcag                                                   20


<210>  2850
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2850
cgagggctgt ggacgccctg                                                   20


<210>  2851
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2851
ggccttctga gcagaatgga                                                   20


<210>  2852
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2852
ccagatccca ttggaccacc                                                   20


<210>  2853
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2853
cattggccta ttcccggcgc                                                   20


<210>  2854
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2854
ccgcgtcagg tgccagcaca                                                   20


<210>  2855
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2855
cagctaggca gccacgtaga                                                   20


<210>  2856
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2856
atgtgatgat gtccaccgcg                                                   20


<210>  2857
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2857
agtcatctct ctgtgcagtt                                                   20


<210>  2858
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2858
gtctcatcca ggggaacctt                                                   20


<210>  2859
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2859
gcgtaggagc agtcaagaga                                                   20


<210>  2860
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2860
agactaatgc ctcatttgtt                                                   20


<210>  2861
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2861
agagatggag ctggtccccc                                                   20


<210>  2862
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2862
ggctaaccca tctctcctcg                                                   20


<210>  2863
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2863
aacgatctca gtggagaacg                                                   20


<210>  2864
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2864
ccctcagggc aggctgagcg                                                   20


<210>  2865
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2865
gcctgcccat ctgctgaacc                                                   20


<210>  2866
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2866
caatcattgg gcaggtggag                                                   20


<210>  2867
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2867
cctagaaagc caggcctccc                                                   20


<210>  2868
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2868
gcactacttg gcaacctcct                                                   20


<210>  2869
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2869
aaggctagtg gagacctggg                                                   20


<210>  2870
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2870
agattcattg gtgccgaggg                                                   20


<210>  2871
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2871
ggcaacggcg gcagtgggcg                                                   20


<210>  2872
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2872
ctttgaccgg taagtaggag                                                   20


<210>  2873
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2873
cctcacaggc cacgctctcc                                                   20


<210>  2874
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2874
caagaaatgc ctggagaaag                                                   20


<210>  2875
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2875
cctaactaac actggatccc                                                   20


<210>  2876
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2876
tctttatctt cctccagtgc                                                   20


<210>  2877
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2877
gccagccctc ctggggcccg                                                   20


<210>  2878
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2878
tggcaggcag cggcagttgt                                                   20


<210>  2879
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2879
aacgatgata aaggtcatgc                                                   20


<210>  2880
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2880
catgtctatc aagtcagaac                                                   20


<210>  2881
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2881
ggactagatt ctcagagctc                                                   20


<210>  2882
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2882
attcagcggg gcacgacaaa                                                   20


<210>  2883
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2883
cctccaagtg taagcggtgg                                                   20


<210>  2884
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2884
gacgcactgc agctcggcct                                                   20


<210>  2885
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2885
aagccacctt gttgttagga                                                   20


<210>  2886
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2886
aagttcaact ctggtttaaa                                                   20


<210>  2887
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2887
cctagccctc tgccagattt                                                   20


<210>  2888
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2888
gagcattcct ccttgttatc                                                   20


<210>  2889
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2889
agggcctcta cagtggcgta                                                   20


<210>  2890
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2890
cctgatcctg tcggtccagc                                                   20


<210>  2891
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2891
gcagctgcag gctgcgcacc                                                   20


<210>  2892
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2892
gctaggggct gaagtccctc                                                   20


<210>  2893
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2893
gagctagaag atcctcgcca                                                   20


<210>  2894
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2894
agagcatttc ttgaatccag                                                   20


<210>  2895
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2895
ggcccagacc ccatagccaa                                                   20


<210>  2896
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2896
gggacagccg cctgaccagc                                                   20


<210>  2897
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2897
agacatacct cttgtccttg                                                   20


<210>  2898
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2898
caggcgagca gcatggtgtc                                                   20


<210>  2899
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2899
tgacacccac aacatgtcag                                                   20


<210>  2900
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2900
aagtgttaaa gaggctttgc                                                   20


<210>  2901
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2901
ggcctgagtg cgggcgcggg                                                   20


<210>  2902
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2902
gcggctatgc tgggagcatg                                                   20


<210>  2903
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2903
gctgatcctg ctggtcctgc                                                   20


<210>  2904
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2904
ccacatattt gtgctggagc                                                   20


<210>  2905
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2905
cccccagaga gagagtggtg                                                   20


<210>  2906
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2906
gaggtatgtc tccagcaggt                                                   20


<210>  2907
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2907
caagatgcgt gctctggagg                                                   20


<210>  2908
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2908
tgcgaacttt tcaccaccat                                                   20


<210>  2909
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2909
gctagtgctc ccggtcctgc                                                   20


<210>  2910
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2910
tggtagctgg acaacaaaaa                                                   20


<210>  2911
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2911
ccatcagtga cggcctgggt                                                   20


<210>  2912
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2912
gtctcatgcc tgctcgtggt                                                   20


<210>  2913
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2913
ggcttcatgc ccatgtatgt                                                   20


<210>  2914
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2914
ctcacggccc tggcagtcct                                                   20


<210>  2915
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2915
ctggctagag gcgaggcttc                                                   20


<210>  2916
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2916
gatgatcccc caggtcgcga                                                   20


<210>  2917
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2917
cctcaggggc caacaggtcc                                                   20


<210>  2918
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2918
cggctacaga tgccattgag                                                   20


<210>  2919
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2919
gaaatggttc tccttgcttg                                                   20


<210>  2920
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2920
gtaccttcag cttggaagtc                                                   20


<210>  2921
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2921
gctgcaggtc cccccggccc                                                   20


<210>  2922
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2922
catgatgatc aaggtgctcc                                                   20


<210>  2923
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2923
ccctgaccct cagggtgtca                                                   20


<210>  2924
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2924
gcctatctcc tgggttcccg                                                   20


<210>  2925
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2925
atggagagat tgatcctaaa                                                   20


<210>  2926
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2926
agtctaggag aatttactac                                                   20


<210>  2927
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2927
atcccttaaa aagcatttcc                                                   20


<210>  2928
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2928
cgcagtcccc caggtgagag                                                   20


<210>  2929
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2929
gtctcatgcc tgcttgtggt                                                   20


<210>  2930
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2930
tgggctattg ggggcccaga                                                   20


<210>  2931
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2931
tggctatgcc accagtagca                                                   20


<210>  2932
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2932
cctggtgact gtgcgttctg                                                   20


<210>  2933
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2933
caccaccgtg ctgggcaatc                                                   20


<210>  2934
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2934
tatctagcgg aaggcctctg                                                   20


<210>  2935
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2935
aagagacgag ccagcgcaag                                                   20


<210>  2936
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2936
cctgaacctc ctggtgcccc                                                   20


<210>  2937
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2937
aatgatgctc ctggactgcg                                                   20


<210>  2938
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2938
tgaacctact ccacgcccac                                                   20


<210>  2939
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2939
cctgctagtc ctagggtagg                                                   20


<210>  2940
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2940
ttcaggagct tcagttgttc                                                   20


<210>  2941
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2941
ctgctatctg cttgcattcg                                                   20


<210>  2942
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2942
tcctaccgct cactcggcag                                                   20


<210>  2943
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2943
ctgactccag ctgtcgtcac                                                   20


<210>  2944
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2944
cctgaaaagc ctggtattcc                                                   20


<210>  2945
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2945
acctgatcct catggccccg                                                   20


<210>  2946
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2946
gatcacctct cagagtcctc                                                   20


<210>  2947
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2947
actccatgac agtgtaattt                                                   20


<210>  2948
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2948
ctgctagtcc agggggctgg                                                   20


<210>  2949
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2949
ctgccagact gcatccaggc                                                   20


<210>  2950
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2950
tctaggagcc tctgtttact                                                   20


<210>  2951
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2951
gtgttccaac ctgagaatgc                                                   20


<210>  2952
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2952
cgagatatga tgaaggagat                                                   20


<210>  2953
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2953
acaagccccg ttggagctgc                                                   20


<210>  2954
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2954
gtcccagaag gaggcccagc                                                   20


<210>  2955
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2955
ggcctcgagt cagttcgagt                                                   20


<210>  2956
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2956
ccaaaggcta catttcatga                                                   20


<210>  2957
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2957
ttatccggga gccccctgta                                                   20


<210>  2958
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2958
ttaaggagca ctggaaccgg                                                   20


<210>  2959
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2959
ctacagtccc ctcatccagc                                                   20


<210>  2960
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2960
cggcgttgca ctggcacact                                                   20


<210>  2961
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2961
cgggcacatt gtggagggct                                                   20


<210>  2962
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2962
tgacgtcgtg gtgagcagct                                                   20


<210>  2963
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2963
gattcccagt tatgtccaat                                                   20


<210>  2964
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2964
tggtgggaac atctggtgga                                                   20


<210>  2965
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2965
ttcatccaag taatggcatc                                                   20


<210>  2966
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2966
gcggggagtg gctgggggac                                                   20


<210>  2967
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2967
gatgaacgcg atgtagctat                                                   20


<210>  2968
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2968
agaagggctc cgggtgagaa                                                   20


<210>  2969
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2969
ctagctggac tccggacctg                                                   20


<210>  2970
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2970
agagggggct gcagggccag                                                   20


<210>  2971
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2971
gctcgcccac ctgctggccc                                                   20


<210>  2972
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2972
aaggattagc cccacagatg                                                   20


<210>  2973
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2973
caaggacaac actgatcgcc                                                   20


<210>  2974
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2974
aagtagatgc tgctgtcaga                                                   20


<210>  2975
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2975
tcccactaga tctccttcct                                                   20


<210>  2976
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2976
gcattctcca ggaaagccga                                                   20


<210>  2977
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2977
ttctgccaat gtgaaattaa                                                   20


<210>  2978
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2978
ggcaagggtc ttctacatgt                                                   20


<210>  2979
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2979
cgccaggtat ttcggggtgc                                                   20


<210>  2980
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2980
agctgaacat ggtgcagaac                                                   20


<210>  2981
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2981
gggctacaag tcaccaccgt                                                   20


<210>  2982
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2982
gagctgtcac acatccagat                                                   20


<210>  2983
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2983
tccagtcagt aaagagtaga                                                   20


<210>  2984
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2984
acagagctag ccgccccagt                                                   20


<210>  2985
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2985
gccccgccat tctccacgat                                                   20


<210>  2986
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2986
atgaggcctc cagggcttcc                                                   20


<210>  2987
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2987
aaggacgacc gtggagaccc                                                   20


<210>  2988
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2988
gcatgtccca aaatatattt                                                   20


<210>  2989
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2989
gttacgtgac aaaattctgc                                                   20


<210>  2990
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2990
tgaccgacta cagcaggtgc                                                   20


<210>  2991
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2991
ccttgggcat ggtgtgcggg                                                   20


<210>  2992
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2992
gtctctgtag atgattgact                                                   20


<210>  2993
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2993
gaagagtaca gaaagagaga                                                   20


<210>  2994
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2994
gggtaagggc atgacgctga                                                   20


<210>  2995
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2995
gcgtccagcc ctgcacgttc                                                   20


<210>  2996
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2996
cgagccgccc agcgagctca                                                   20


<210>  2997
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2997
gttgaagaag cacttgatct                                                   20


<210>  2998
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2998
ctagctggga ctgagagacc                                                   20


<210>  2999
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2999
aaaagagagc cgtggggaga                                                   20


<210>  3000
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3000
ctctttcagc ccaggccctc                                                   20


<210>  3001
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3001
cgggataatg acggtgctcg                                                   20


<210>  3002
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3002
ggttccacta gtagtgctgg                                                   20


<210>  3003
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3003
gtttcctcag acagcaggtg                                                   20


<210>  3004
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3004
ccttacatgc cctggtaagt                                                   20


<210>  3005
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3005
ggccagctag tcgcgttcgg                                                   20


<210>  3006
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3006
cgcttcctga tgctgggccc                                                   20


<210>  3007
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3007
cctcaattct agaaaggcag                                                   20


<210>  3008
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3008
ccgggagcac acggaggagc                                                   20


<210>  3009
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3009
cctgacatga tactgcttcc                                                   20


<210>  3010
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3010
ctactcccac aacaaggctc                                                   20


<210>  3011
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3011
ctcaaggacc ctcttgtccg                                                   20


<210>  3012
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3012
atcagccttt accaacttgc                                                   20


<210>  3013
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3013
cctgaagccc ccggaccacc                                                   20


<210>  3014
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3014
gtatttactg agttccccac                                                   20


<210>  3015
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3015
tgcatgctag ctgcacatat                                                   20


<210>  3016
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3016
ggagggcaag gagtgcaggt                                                   20


<210>  3017
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3017
tccaatatgc tgagaggcat                                                   20


<210>  3018
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3018
cagcaaggtg gccacacaga                                                   20


<210>  3019
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3019
gtaagtgcag ttggtccccc                                                   20


<210>  3020
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3020
atcactgttc aatttcctgt                                                   20


<210>  3021
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3021
ggaagtgcac acctgacagg                                                   20


<210>  3022
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3022
caaagtcctc ctggtcccag                                                   20


<210>  3023
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3023
tccaagaggc aaatttccag                                                   20


<210>  3024
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3024
actgacaccc tatatcccca                                                   20


<210>  3025
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3025
cgatgcacta cagcagggcc                                                   20


<210>  3026
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3026
ctcaataggc acgagcagac                                                   20


<210>  3027
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3027
gtgcaacatg gctcgcattg                                                   20


<210>  3028
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3028
cgggtacagg agggctctgg                                                   20


<210>  3029
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3029
gatcctcacc agggaggagg                                                   20


<210>  3030
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3030
cagcagccta gatcattgcc                                                   20


<210>  3031
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3031
gcaggcctcc ggaatcaccc                                                   20


<210>  3032
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3032
ggactgcaaa accaaaccaa                                                   20


<210>  3033
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3033
ctcaaggccg ccgtctgcgc                                                   20


<210>  3034
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3034
cccacctcat gatcgttctg                                                   20


<210>  3035
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3035
atgtctaagt gagtaggcat                                                   20


<210>  3036
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3036
attgctttta cctagtgcta                                                   20


<210>  3037
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3037
ctggcttcta ggtttctgct                                                   20


<210>  3038
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3038
caagcgggac aaggcccacg                                                   20


<210>  3039
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3039
ggagggctag ccggccggcc                                                   20


<210>  3040
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3040
cagcagcacc ttctgtgagc                                                   20


<210>  3041
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3041
cctcaaggcc tgggtgctgc                                                   20


<210>  3042
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3042
tacgcctcca gcaggaccac                                                   20


<210>  3043
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3043
tgggaagcta gagccacacc                                                   20


<210>  3044
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3044
tctttcccac acggccgtcc                                                   20


<210>  3045
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3045
tgcaggttag ttcctgtccc                                                   20


<210>  3046
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3046
ttctagaatg atgacggtga                                                   20


<210>  3047
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3047
tctcagcgtt tatcactgtc                                                   20


<210>  3048
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3048
agctacagag agctgggctg                                                   20


<210>  3049
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3049
gatctccagc tgtgcaaact                                                   20


<210>  3050
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3050
acgaccaggt atggtgcggc                                                   20


<210>  3051
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3051
ccacatactg tccgagctgg                                                   20


<210>  3052
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3052
aacagcatct gggaaagtag                                                   20


<210>  3053
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3053
ccattggaaa cagcgcatgg                                                   20


<210>  3054
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3054
cgaagcggcc ccgggcgcga                                                   20


<210>  3055
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3055
agagaagccc ctggatggcc                                                   20


<210>  3056
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3056
attagaagag taggaagatt                                                   20


<210>  3057
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3057
ctcttcctca tatctccaca                                                   20


<210>  3058
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3058
ctacttgttg tcccggtaga                                                   20


<210>  3059
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3059
ttccacagag catgtctcag                                                   20


<210>  3060
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3060
gtgaccactg atcggaaacg                                                   20


<210>  3061
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3061
actatagcac agctttatcc                                                   20


<210>  3062
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3062
agacaccatg aaagctgcca                                                   20


<210>  3063
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3063
cggccagatg accatccaat                                                   20


<210>  3064
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3064
aaagctgaaa agggacgaac                                                   20


<210>  3065
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3065
aagttagcaa accaggagaa                                                   20


<210>  3066
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3066
ccaaggcctg atggtgaacc                                                   20


<210>  3067
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3067
cagctacagc tccctgccat                                                   20


<210>  3068
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3068
ataaaagaag gccaggacat                                                   20


<210>  3069
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3069
ctcaggaatc agatgcacca                                                   20


<210>  3070
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3070
tcacctcttg gcagctcttt                                                   20


<210>  3071
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3071
aacagccagc tggggtagaa                                                   20


<210>  3072
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3072
gtcactggtt ctcgtggtcc                                                   20


<210>  3073
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3073
ataatcctag tttacttcag                                                   20


<210>  3074
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3074
cgcagatctg atactcaaag                                                   20


<210>  3075
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3075
gctaccagaa atgccgagcc                                                   20


<210>  3076
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3076
gcgtgagcta cgggtcccac                                                   20


<210>  3077
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3077
aatctgattc cagaacagga                                                   20


<210>  3078
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3078
ggaccccctg gccgactacc                                                   20


<210>  3079
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3079
tggaagccct gagggtggag                                                   20


<210>  3080
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3080
gatggcattt caagactggt                                                   20


<210>  3081
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3081
aatccctgta aagatattat                                                   20


<210>  3082
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3082
agggcaagga gtgcaggtga                                                   20


<210>  3083
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3083
cagtggatac atctcgggca                                                   20


<210>  3084
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3084
ccttggctca cttcagcagc                                                   20


<210>  3085
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3085
cacaacatgc ccatttatga                                                   20


<210>  3086
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3086
gctagtgaag ttggcaaacc                                                   20


<210>  3087
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3087
cccttcccaa ttgtctggaa                                                   20


<210>  3088
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3088
tgactataaa tggagtgaga                                                   20


<210>  3089
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3089
ctgagttctc catgagtgtt                                                   20


<210>  3090
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3090
aggcagaaga ctctgggtct                                                   20


<210>  3091
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3091
cgagtggtgc cgcacgaagc                                                   20


<210>  3092
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3092
ctgactgaag tggacggaca                                                   20


<210>  3093
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3093
ggatgaacag ggcccagcac                                                   20


<210>  3094
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3094
actgaagcac ggggtcttgc                                                   20


<210>  3095
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3095
atcagccccg ctggaaaaga                                                   20


<210>  3096
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3096
agaagccaca caatatcaag                                                   20


<210>  3097
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3097
gtacgctctt gaggttgtaa                                                   20


<210>  3098
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3098
ccaccttcat gccaatgtca                                                   20


<210>  3099
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3099
gcttggccaa cttcccaaac                                                   20


<210>  3100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3100
actcagagtt gccgtattcg                                                   20


<210>  3101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3101
ctgtctttta gaacaggatg                                                   20


<210>  3102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3102
cgtcgagctt ctgcttctcc                                                   20


<210>  3103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3103
tcttcaagat atcaaagaac                                                   20


<210>  3104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3104
gggctagagc atctttgagc                                                   20


<210>  3105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3105
cgagggggcc cctctcccca                                                   20


<210>  3106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3106
ggctcacagg gcacagagca                                                   20


<210>  3107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3107
ccactggggc ccccgagacc                                                   20


<210>  3108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3108
ccaaggcctc gaggtaacag                                                   20


<210>  3109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3109
aaaagtgaac agggtccccc                                                   20


<210>  3110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3110
tggtgttgga taaatccggg                                                   20


<210>  3111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3111
cagctcagtt cgtggacgcc                                                   20


<210>  3112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3112
ttcactccta gaagttcttc                                                   20


<210>  3113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3113
agcatggatg ggatgtgctg                                                   20


<210>  3114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3114
gatagggagt tgccaggaga                                                   20


<210>  3115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3115
cgagaacctg ctggaccaaa                                                   20


<210>  3116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3116
ggacttggca gctgcgcggc                                                   20


<210>  3117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3117
ggtcttgcta gtgctcgggt                                                   20


<210>  3118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3118
cagcaccatg acccaggtga                                                   20


<210>  3119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3119
agaagcacat ggcttcataa                                                   20


<210>  3120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3120
ctcaaggtcc aggttaaatc                                                   20


<210>  3121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3121
ccgtgctgag gctgttcgtg                                                   20


<210>  3122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3122
ggctgtcatc accaatccca                                                   20


<210>  3123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3123
gagagcagtc atctttcccc                                                   20


<210>  3124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3124
gccaagaccc acttcaaaga                                                   20


<210>  3125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3125
aaagatgaaa caggtgaacg                                                   20


<210>  3126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3126
ttcaccctga gagacctctc                                                   20


<210>  3127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3127
cccagaaaag atggtgttcc                                                   20


<210>  3128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3128
gggcatccta gggaatgtcc                                                   20


<210>  3129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3129
cgcacaagga gctctacaag                                                   20


<210>  3130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3130
gctacaccca gggcgctagc                                                   20


<210>  3131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3131
tctacagctc tgggaggctc                                                   20


<210>  3132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3132
gtatggcaaa ggtgcccttg                                                   20


<210>  3133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3133
ctggcagaag gcctctgtgg                                                   20


<210>  3134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3134
gctaggggtg gtggctgttg                                                   20


<210>  3135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3135
gatccggttc tggctccagt                                                   20


<210>  3136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3136
acagggcctt agtgtatcac                                                   20


<210>  3137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3137
caggatgacc caggacttaa                                                   20


<210>  3138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3138
agtgctccag tttacctaaa                                                   20


<210>  3139
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3139
ctgggagatg atgctgatcc                                                   20


<210>  3140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3140
acctacaccc tagccaagtg                                                   20


<210>  3141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3141
tgactagaag gacgtcctgt                                                   20


<210>  3142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3142
cagagtggta ggagtgtgga                                                   20


<210>  3143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3143
catccagtag atcaaggaga                                                   20


<210>  3144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3144
actgaatcac caggaattcc                                                   20


<210>  3145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3145
atcaagtctc cgctgatacc                                                   20


<210>  3146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3146
taataactca agcaaccttc                                                   20


<210>  3147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3147
agcacttgat gtgcttggct                                                   20


<210>  3148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3148
gcgctagtgg tacggggaga                                                   20


<210>  3149
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3149
cactagtggt tgacgaactc                                                   20


<210>  3150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3150
gatggactac ttcaggcgtg                                                   20


<210>  3151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3151
aactgctaga tgccgttcaa                                                   20


<210>  3152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3152
gtgaagtgtc tatctttcat                                                   20


<210>  3153
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3153
cacatggaga agatcttctc                                                   20


<210>  3154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3154
agctgtctaa cagttggcct                                                   20


<210>  3155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3155
gagctagatc cggtccatca                                                   20


<210>  3156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3156
ggttctaatt tggaataggc                                                   20


<210>  3157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3157
cggaaggtct aagagatggt                                                   20


<210>  3158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3158
gtctaaagaa cacccccagg                                                   20


<210>  3159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3159
gaagctagcg agtcagtaac                                                   20


<210>  3160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3160
cccagactct accatttttc                                                   20


<210>  3161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3161
gaaactaggt gaggccgcca                                                   20


<210>  3162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3162
aagcaaagag aggccctaat                                                   20


<210>  3163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3163
agacgaagta caactgaagg                                                   20


<210>  3164
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3164
tctaagtgtt gggtccgtcc                                                   20


<210>  3165
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3165
aatgactatg cctacctcaa                                                   20


<210>  3166
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3166
cctgaacgag agctttggct                                                   20


<210>  3167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3167
cctagaggga gacggtgcgc                                                   20


<210>  3168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3168
ggctaaaaac ggggtctctg                                                   20


<210>  3169
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3169
ggactagtga atgcttcctg                                                   20


<210>  3170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3170
acagagctag ctaacgatct                                                   20


<210>  3171
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3171
cttgaactag cggtccccat                                                   20


<210>  3172
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3172
agcactatgc cttaacagat                                                   20


<210>  3173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3173
gtccccaaaa ccgttgttgc                                                   20


<210>  3174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3174
gaagactgca ggtcagccct                                                   20


<210>  3175
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3175
tctccccctt ctccctgaaa                                                   20


<210>  3176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3176
gacccctgcc agcgtcatgg                                                   20


<210>  3177
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3177
gcactgctaa gcgccagcct                                                   20


<210>  3178
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3178
aaagaactct gaattaggta                                                   20


<210>  3179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3179
gacctgctag aggaagtcga                                                   20


<210>  3180
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3180
gaactaatgc gccctgttca                                                   20


<210>  3181
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3181
gaggcacata taggtcttga                                                   20


<210>  3182
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3182
gggaagctag gccaaagtgc                                                   20


<210>  3183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3183
tccctaggtg aagatggaaa                                                   20


<210>  3184
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3184
gccccaacat agtaattcct                                                   20


<210>  3185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3185
ctctgagcta gttgatctcg                                                   20


<210>  3186
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3186
gtagtactat acgccatggc                                                   20


<210>  3187
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3187
acagtgctaa gaggaggacc                                                   20


<210>  3188
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3188
ctgaagctga agtagagcgc                                                   20


<210>  3189
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3189
cacgtctaaa gaacaccccc                                                   20


<210>  3190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3190
ggttacccta cttggagagc                                                   20


<210>  3191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3191
attcactcta aagctggaaa                                                   20


<210>  3192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3192
agccagctac atgtaggggt                                                   20


<210>  3193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3193
gctctaagtg ccattgccgt                                                   20


<210>  3194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3194
gcgtacttct aacaggtcag                                                   20


<210>  3195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3195
gctggggatc taggggccgg                                                   20


<210>  3196
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3196
gccgctgtgg tgcaccacgc                                                   20


<210>  3197
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3197
ctctagggca tggggtggct                                                   20


<210>  3198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3198
ggaaggtcta agagatggta                                                   20


<210>  3199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3199
gaggacgacg acgtcaccaa                                                   20


<210>  3200
<211>  1859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3200

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile 
        275                 280                 285             


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val 
    290                 295                 300                 


Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile 
305                 310                 315                 320 


Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala 
                325                 330                 335     


Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
            340                 345                 350         


Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala 
        355                 360                 365             


Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val 
    370                 375                 380                 


Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val 
385                 390                 395                 400 


Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg 
                405                 410                 415     


Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr 
            420                 425                 430         


Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu 
        435                 440                 445             


Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln 
    450                 455                 460                 


Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala 
465                 470                 475                 480 


Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser 
                485                 490                 495     


Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn 
            500                 505                 510         


Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn 
        515                 520                 525             


Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser 
    530                 535                 540                 


Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly 
545                 550                 555                 560 


Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala 
                565                 570                 575     


Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala 
            580                 585                 590         


Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp 
        595                 600                 605             


Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr 
    610                 615                 620                 


Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile 
625                 630                 635                 640 


Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile 
                645                 650                 655     


Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg 
            660                 665                 670         


Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
        675                 680                 685             


His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu 
    690                 695                 700                 


Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile 
705                 710                 715                 720 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
                725                 730                 735     


Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro 
            740                 745                 750         


Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe 
        755                 760                 765             


Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val 
    770                 775                 780                 


Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu 
785                 790                 795                 800 


Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe 
                805                 810                 815     


Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr 
            820                 825                 830         


Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys 
        835                 840                 845             


Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe 
    850                 855                 860                 


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp 
865                 870                 875                 880 


Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile 
                885                 890                 895     


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg 
            900                 905                 910         


Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu 
        915                 920                 925             


Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile 
    930                 935                 940                 


Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu 
945                 950                 955                 960 


Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp 
                965                 970                 975     


Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly 
            980                 985                 990         


Gln Gly Asp Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
        995                 1000                 1005             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1010                 1015                 1020             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1025                 1030                 1035             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1040                 1045                 1050             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1055                 1060                 1065             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1070                 1075                 1080             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1085                 1090                 1095             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1100                 1105                 1110             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1115                 1120                 1125             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1130                 1135                 1140             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1145                 1150                 1155             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1160                 1165                 1170             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1175                 1180                 1185             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1190                 1195                 1200             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1205                 1210                 1215             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1220                 1225                 1230             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1235                 1240                 1245             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1250                 1255                 1260             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1265                 1270                 1275             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1280                 1285                 1290             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1295                 1300                 1305             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1310                 1315                 1320             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1325                 1330                 1335             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1340                 1345                 1350             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1355                 1360                 1365             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1370                 1375                 1380             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1385                 1390                 1395             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1400                 1405                 1410             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1415                 1420                 1425             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1430                 1435                 1440             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1445                 1450                 1455             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1460                 1465                 1470             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1475                 1480                 1485             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1490                 1495                 1500             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1505                 1510                 1515             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1520                 1525                 1530             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1535                 1540                 1545             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1550                 1555                 1560             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1565                 1570                 1575             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1580                 1585                 1590             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1595                 1600                 1605             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1610                 1615                 1620             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1625                 1630                 1635             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1640                 1645                 1650             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1655                 1660                 1665             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1670                 1675                 1680             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1685                 1690                 1695             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1700                 1705                 1710             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1715                 1720                 1725             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1730                 1735                 1740             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1745                 1750                 1755             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1760                 1765                 1770             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1775                 1780                 1785             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1790                 1795                 1800             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1805                 1810                 1815             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1820                 1825                 1830             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Lys Arg Thr  Ala Asp Gly 
    1835                 1840                 1845             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1850                 1855                 


<210>  3201
<211>  1859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3201

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg Glu Ala Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile 
        275                 280                 285             


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val 
    290                 295                 300                 


Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile 
305                 310                 315                 320 


Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala 
                325                 330                 335     


Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
            340                 345                 350         


Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala 
        355                 360                 365             


Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val 
    370                 375                 380                 


Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val 
385                 390                 395                 400 


Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg 
                405                 410                 415     


Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr 
            420                 425                 430         


Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu 
        435                 440                 445             


Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln 
    450                 455                 460                 


Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala 
465                 470                 475                 480 


Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser 
                485                 490                 495     


Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn 
            500                 505                 510         


Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn 
        515                 520                 525             


Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser 
    530                 535                 540                 


Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly 
545                 550                 555                 560 


Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala 
                565                 570                 575     


Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala 
            580                 585                 590         


Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp 
        595                 600                 605             


Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr 
    610                 615                 620                 


Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile 
625                 630                 635                 640 


Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile 
                645                 650                 655     


Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg 
            660                 665                 670         


Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
        675                 680                 685             


His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu 
    690                 695                 700                 


Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile 
705                 710                 715                 720 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
                725                 730                 735     


Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro 
            740                 745                 750         


Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe 
        755                 760                 765             


Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val 
    770                 775                 780                 


Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu 
785                 790                 795                 800 


Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe 
                805                 810                 815     


Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr 
            820                 825                 830         


Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys 
        835                 840                 845             


Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe 
    850                 855                 860                 


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp 
865                 870                 875                 880 


Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile 
                885                 890                 895     


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg 
            900                 905                 910         


Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu 
        915                 920                 925             


Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile 
    930                 935                 940                 


Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu 
945                 950                 955                 960 


Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp 
                965                 970                 975     


Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly 
            980                 985                 990         


Gln Gly Asp Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
        995                 1000                 1005             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1010                 1015                 1020             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1025                 1030                 1035             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1040                 1045                 1050             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1055                 1060                 1065             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1070                 1075                 1080             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1085                 1090                 1095             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1100                 1105                 1110             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1115                 1120                 1125             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1130                 1135                 1140             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1145                 1150                 1155             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1160                 1165                 1170             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1175                 1180                 1185             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1190                 1195                 1200             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1205                 1210                 1215             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1220                 1225                 1230             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1235                 1240                 1245             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1250                 1255                 1260             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1265                 1270                 1275             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1280                 1285                 1290             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1295                 1300                 1305             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1310                 1315                 1320             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1325                 1330                 1335             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1340                 1345                 1350             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1355                 1360                 1365             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1370                 1375                 1380             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1385                 1390                 1395             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1400                 1405                 1410             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1415                 1420                 1425             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1430                 1435                 1440             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1445                 1450                 1455             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1460                 1465                 1470             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1475                 1480                 1485             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1490                 1495                 1500             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1505                 1510                 1515             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1520                 1525                 1530             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1535                 1540                 1545             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1550                 1555                 1560             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1565                 1570                 1575             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1580                 1585                 1590             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1595                 1600                 1605             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1610                 1615                 1620             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1625                 1630                 1635             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1640                 1645                 1650             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1655                 1660                 1665             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1670                 1675                 1680             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1685                 1690                 1695             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1700                 1705                 1710             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1715                 1720                 1725             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1730                 1735                 1740             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1745                 1750                 1755             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1760                 1765                 1770             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1775                 1780                 1785             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1790                 1795                 1800             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1805                 1810                 1815             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1820                 1825                 1830             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Lys Arg Thr  Ala Asp Gly 
    1835                 1840                 1845             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1850                 1855                 


<210>  3202
<211>  1828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3202

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln 
            20                  25                  30          


Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
        35                  40                  45              


Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe 
    50                  55                  60                  


Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu 
65                  70                  75                  80  


Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val 
                85                  90                  95      


Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val 
            100                 105                 110         


Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr 
        115                 120                 125             


Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu 
    130                 135                 140                 


Arg Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys 
145                 150                 155                 160 


Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr 
                165                 170                 175     


Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg 
            180                 185                 190         


Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg 
        195                 200                 205             


Asp Ala Phe Arg Thr Leu Gly Leu Ser Gly Gly Ser Ser Gly Gly Ser 
    210                 215                 220                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
225                 230                 235                 240 


Ser Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
                245                 250                 255     


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
            260                 265                 270         


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
        275                 280                 285             


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
    290                 295                 300                 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
305                 310                 315                 320 


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
                325                 330                 335     


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
            340                 345                 350         


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
        355                 360                 365             


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
    370                 375                 380                 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
385                 390                 395                 400 


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
                405                 410                 415     


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
            420                 425                 430         


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
        435                 440                 445             


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
    450                 455                 460                 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
465                 470                 475                 480 


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
                485                 490                 495     


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
            500                 505                 510         


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
        515                 520                 525             


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
    530                 535                 540                 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
545                 550                 555                 560 


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
                565                 570                 575     


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
            580                 585                 590         


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
        595                 600                 605             


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
    610                 615                 620                 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
625                 630                 635                 640 


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
                645                 650                 655     


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
            660                 665                 670         


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
        675                 680                 685             


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
    690                 695                 700                 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
705                 710                 715                 720 


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
                725                 730                 735     


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
            740                 745                 750         


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
        755                 760                 765             


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
    770                 775                 780                 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
785                 790                 795                 800 


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
                805                 810                 815     


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
            820                 825                 830         


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
        835                 840                 845             


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
    850                 855                 860                 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
865                 870                 875                 880 


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
                885                 890                 895     


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
            900                 905                 910         


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
        915                 920                 925             


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
    930                 935                 940                 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
945                 950                 955                 960 


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
                965                 970                 975     


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
            980                 985                 990         


Leu Val Lys Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
        995                 1000                 1005             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1010                 1015                 1020             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1025                 1030                 1035             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1040                 1045                 1050             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1055                 1060                 1065             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1070                 1075                 1080             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1085                 1090                 1095             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1100                 1105                 1110             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1115                 1120                 1125             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1130                 1135                 1140             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1145                 1150                 1155             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1160                 1165                 1170             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1175                 1180                 1185             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1190                 1195                 1200             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1205                 1210                 1215             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1220                 1225                 1230             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1235                 1240                 1245             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1250                 1255                 1260             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1265                 1270                 1275             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1280                 1285                 1290             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1295                 1300                 1305             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1310                 1315                 1320             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1325                 1330                 1335             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1340                 1345                 1350             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1355                 1360                 1365             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1370                 1375                 1380             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1385                 1390                 1395             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1400                 1405                 1410             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1415                 1420                 1425             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1430                 1435                 1440             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1445                 1450                 1455             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1460                 1465                 1470             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1475                 1480                 1485             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1490                 1495                 1500             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1505                 1510                 1515             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1520                 1525                 1530             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1535                 1540                 1545             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1550                 1555                 1560             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1565                 1570                 1575             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1580                 1585                 1590             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1595                 1600                 1605             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1610                 1615                 1620             


Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln 
    1625                 1630                 1635             


Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu 
    1640                 1645                 1650             


Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp Ile Leu  Val His Thr 
    1655                 1660                 1665             


Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser 
    1670                 1675                 1680             


Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser 
    1685                 1690                 1695             


Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser Gly Gly  Ser Gly Gly 
    1700                 1705                 1710             


Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1715                 1720                 1725             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1730                 1735                 1740             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1745                 1750                 1755             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1760                 1765                 1770             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1775                 1780                 1785             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly 
    1790                 1795                 1800             


Ser Pro  Lys Lys Lys Arg Lys  Val Lys Arg Thr Ala  Asp Gly Ser 
    1805                 1810                 1815             


Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1820                 1825             


<210>  3203
<211>  1838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3203

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp 
            20                  25                  30          


Ile Tyr Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser 
        35                  40                  45              


His Arg Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg 
    50                  55                  60                  


Ala Cys Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu 
65                  70                  75                  80  


Arg Gly Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr 
                85                  90                  95      


Leu Arg Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp 
            100                 105                 110         


Ser Pro Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln 
        115                 120                 125             


Glu Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu 
    130                 135                 140                 


Tyr Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg 
145                 150                 155                 160 


Asp Asn Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys 
                165                 170                 175     


Cys Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn 
            180                 185                 190         


Arg Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu 
        195                 200                 205             


Leu Ser Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro 
    210                 215                 220                 


Ala Val Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
                245                 250                 255     


Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            260                 265                 270         


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        275                 280                 285             


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    290                 295                 300                 


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
305                 310                 315                 320 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                325                 330                 335     


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            340                 345                 350         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        355                 360                 365             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    370                 375                 380                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
385                 390                 395                 400 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                405                 410                 415     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            420                 425                 430         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        435                 440                 445             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    450                 455                 460                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
465                 470                 475                 480 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                485                 490                 495     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            500                 505                 510         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        515                 520                 525             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    530                 535                 540                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
545                 550                 555                 560 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                565                 570                 575     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            580                 585                 590         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        595                 600                 605             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    610                 615                 620                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
625                 630                 635                 640 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                645                 650                 655     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            660                 665                 670         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        675                 680                 685             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    690                 695                 700                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
705                 710                 715                 720 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                725                 730                 735     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            740                 745                 750         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        755                 760                 765             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    770                 775                 780                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
785                 790                 795                 800 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                805                 810                 815     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            820                 825                 830         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        835                 840                 845             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    850                 855                 860                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
865                 870                 875                 880 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                885                 890                 895     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            900                 905                 910         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        915                 920                 925             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    930                 935                 940                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
945                 950                 955                 960 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                965                 970                 975     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            980                 985                 990         


Ile Leu Gln Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
        995                 1000                 1005             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1010                 1015                 1020             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1025                 1030                 1035             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1040                 1045                 1050             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1055                 1060                 1065             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1070                 1075                 1080             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1085                 1090                 1095             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1100                 1105                 1110             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1115                 1120                 1125             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1130                 1135                 1140             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1145                 1150                 1155             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1160                 1165                 1170             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1175                 1180                 1185             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1190                 1195                 1200             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1205                 1210                 1215             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1220                 1225                 1230             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1235                 1240                 1245             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1250                 1255                 1260             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1265                 1270                 1275             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1280                 1285                 1290             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1295                 1300                 1305             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1310                 1315                 1320             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1325                 1330                 1335             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1340                 1345                 1350             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1355                 1360                 1365             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1370                 1375                 1380             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1385                 1390                 1395             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1400                 1405                 1410             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1415                 1420                 1425             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1430                 1435                 1440             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1445                 1450                 1455             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1460                 1465                 1470             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1475                 1480                 1485             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1490                 1495                 1500             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1505                 1510                 1515             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1520                 1525                 1530             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1535                 1540                 1545             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1550                 1555                 1560             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1565                 1570                 1575             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1580                 1585                 1590             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1625                 1630                 1635             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1640                 1645                 1650             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1655                 1660                 1665             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1670                 1675                 1680             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1685                 1690                 1695             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1700                 1705                 1710             


Ile Lys  Met Leu Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1715                 1720                 1725             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1730                 1735                 1740             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1745                 1750                 1755             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1760                 1765                 1770             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1775                 1780                 1785             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1790                 1795                 1800             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Pro  Lys Lys Lys 
    1805                 1810                 1815             


Arg Lys  Val Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1820                 1825                 1830             


Lys Lys  Arg Lys Val 
    1835             


<210>  3204
<211>  1858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3204

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg 
            20                  25                  30          


Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu 
        35                  40                  45              


Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg 
    50                  55                  60                  


His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu 
65                  70                  75                  80  


Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn 
                85                  90                  95      


Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu 
            100                 105                 110         


Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro Asn Val Thr 
        115                 120                 125             


Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His Leu Ala Asn Pro Arg Asn 
    130                 135                 140                 


Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile 
145                 150                 155                 160 


Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp His Asn Phe Val Asn Tyr 
                165                 170                 175     


Ser Pro Ser Asn Glu Ser His Trp Pro Arg Tyr Pro His Leu Trp Val 
            180                 185                 190         


Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro 
        195                 200                 205             


Cys Leu Asn Ile Leu Arg Arg Lys Gln Ser Gln Leu Thr Ser Phe Thr 
    210                 215                 220                 


Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu 
225                 230                 235                 240 


Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
                245                 250                 255     


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
            260                 265                 270         


Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
        275                 280                 285             


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
    290                 295                 300                 


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
305                 310                 315                 320 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
                325                 330                 335     


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
            340                 345                 350         


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
        355                 360                 365             


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
    370                 375                 380                 


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
385                 390                 395                 400 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
                405                 410                 415     


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
            420                 425                 430         


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
        435                 440                 445             


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
    450                 455                 460                 


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
465                 470                 475                 480 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
                485                 490                 495     


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
            500                 505                 510         


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
        515                 520                 525             


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
    530                 535                 540                 


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
545                 550                 555                 560 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
                565                 570                 575     


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
            580                 585                 590         


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
        595                 600                 605             


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
    610                 615                 620                 


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
625                 630                 635                 640 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
                645                 650                 655     


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
            660                 665                 670         


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
        675                 680                 685             


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
    690                 695                 700                 


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
705                 710                 715                 720 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
                725                 730                 735     


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
            740                 745                 750         


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
        755                 760                 765             


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
    770                 775                 780                 


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
785                 790                 795                 800 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
                805                 810                 815     


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
            820                 825                 830         


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
        835                 840                 845             


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
    850                 855                 860                 


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
865                 870                 875                 880 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
                885                 890                 895     


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
            900                 905                 910         


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
        915                 920                 925             


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
    930                 935                 940                 


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
945                 950                 955                 960 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
                965                 970                 975     


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
            980                 985                 990         


Gly Asp Ser Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
        995                 1000                 1005             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1010                 1015                 1020             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1025                 1030                 1035             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1040                 1045                 1050             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1055                 1060                 1065             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1070                 1075                 1080             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1085                 1090                 1095             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1100                 1105                 1110             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1115                 1120                 1125             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1130                 1135                 1140             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1145                 1150                 1155             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1160                 1165                 1170             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1175                 1180                 1185             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1190                 1195                 1200             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1205                 1210                 1215             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1220                 1225                 1230             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1235                 1240                 1245             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1250                 1255                 1260             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1265                 1270                 1275             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1280                 1285                 1290             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1295                 1300                 1305             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1310                 1315                 1320             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1325                 1330                 1335             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1340                 1345                 1350             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1355                 1360                 1365             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1370                 1375                 1380             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1385                 1390                 1395             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1400                 1405                 1410             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1415                 1420                 1425             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1430                 1435                 1440             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1445                 1450                 1455             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1460                 1465                 1470             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1475                 1480                 1485             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1490                 1495                 1500             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1505                 1510                 1515             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1520                 1525                 1530             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1535                 1540                 1545             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1550                 1555                 1560             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1565                 1570                 1575             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1580                 1585                 1590             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1595                 1600                 1605             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1610                 1615                 1620             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1625                 1630                 1635             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1640                 1645                 1650             


Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln 
    1655                 1660                 1665             


Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu 
    1670                 1675                 1680             


Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp Ile Leu  Val His Thr 
    1685                 1690                 1695             


Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser 
    1700                 1705                 1710             


Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser 
    1715                 1720                 1725             


Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser Gly Gly  Ser Gly Gly 
    1730                 1735                 1740             


Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1745                 1750                 1755             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1760                 1765                 1770             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1775                 1780                 1785             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1790                 1795                 1800             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1805                 1810                 1815             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly 
    1820                 1825                 1830             


Ser Pro  Lys Lys Lys Arg Lys  Val Lys Arg Thr Ala  Asp Gly Ser 
    1835                 1840                 1845             


Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1850                 1855             


<210>  3205
<211>  1829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3205

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp 
            20                  25                  30          


Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys 
        35                  40                  45              


Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val 
    50                  55                  60                  


Lys Met Asp Gln His Arg Gly Phe Leu His Gly Gln Ala Lys Asn Leu 
65                  70                  75                  80  


Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu 
                85                  90                  95      


Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp 
            100                 105                 110         


Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val 
        115                 120                 125             


Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala 
    130                 135                 140                 


Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met 
145                 150                 155                 160 


Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe 
                165                 170                 175     


Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln 
            180                 185                 190         


Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu 
        195                 200                 205             


Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
225                 230                 235                 240 


Ser Ser Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu 
                245                 250                 255     


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            260                 265                 270         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        275                 280                 285             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    290                 295                 300                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
305                 310                 315                 320 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                325                 330                 335     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            340                 345                 350         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        355                 360                 365             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    370                 375                 380                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
385                 390                 395                 400 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                405                 410                 415     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            420                 425                 430         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        435                 440                 445             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    450                 455                 460                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
465                 470                 475                 480 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                485                 490                 495     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            500                 505                 510         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        515                 520                 525             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    530                 535                 540                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
545                 550                 555                 560 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                565                 570                 575     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            580                 585                 590         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        595                 600                 605             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    610                 615                 620                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
625                 630                 635                 640 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                645                 650                 655     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            660                 665                 670         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        675                 680                 685             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    690                 695                 700                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
705                 710                 715                 720 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                725                 730                 735     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            740                 745                 750         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        755                 760                 765             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    770                 775                 780                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
785                 790                 795                 800 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                805                 810                 815     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            820                 825                 830         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        835                 840                 845             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    850                 855                 860                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
865                 870                 875                 880 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                885                 890                 895     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            900                 905                 910         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        915                 920                 925             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    930                 935                 940                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
945                 950                 955                 960 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                965                 970                 975     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            980                 985                 990         


Glu Leu Val Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
        995                 1000                 1005             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1010                 1015                 1020             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1025                 1030                 1035             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1040                 1045                 1050             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1055                 1060                 1065             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1070                 1075                 1080             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1085                 1090                 1095             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1100                 1105                 1110             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1115                 1120                 1125             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1130                 1135                 1140             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1145                 1150                 1155             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1160                 1165                 1170             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1175                 1180                 1185             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1190                 1195                 1200             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1205                 1210                 1215             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1220                 1225                 1230             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1235                 1240                 1245             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1250                 1255                 1260             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1265                 1270                 1275             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1280                 1285                 1290             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1295                 1300                 1305             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1310                 1315                 1320             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1325                 1330                 1335             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1340                 1345                 1350             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1355                 1360                 1365             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1370                 1375                 1380             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1385                 1390                 1395             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1400                 1405                 1410             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1415                 1420                 1425             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1430                 1435                 1440             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1445                 1450                 1455             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1460                 1465                 1470             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1475                 1480                 1485             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1490                 1495                 1500             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1505                 1510                 1515             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1520                 1525                 1530             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1535                 1540                 1545             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1550                 1555                 1560             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1565                 1570                 1575             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1580                 1585                 1590             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1595                 1600                 1605             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1610                 1615                 1620             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1625                 1630                 1635             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1640                 1645                 1650             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1655                 1660                 1665             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1670                 1675                 1680             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1685                 1690                 1695             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1700                 1705                 1710             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1715                 1720                 1725             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1730                 1735                 1740             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1745                 1750                 1755             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1760                 1765                 1770             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1775                 1780                 1785             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1790                 1795                 1800             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Lys Arg Thr  Ala Asp Gly 
    1805                 1810                 1815             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1820                 1825                 


<210>  3206
<211>  1829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3206

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp 
            20                  25                  30          


Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys 
        35                  40                  45              


Ala Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val 
    50                  55                  60                  


Lys Met Asp Gln His Arg Gly Phe Leu His Gly Gln Ala Lys Asn Leu 
65                  70                  75                  80  


Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu 
                85                  90                  95      


Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp 
            100                 105                 110         


Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val 
        115                 120                 125             


Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala 
    130                 135                 140                 


Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met 
145                 150                 155                 160 


Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe 
                165                 170                 175     


Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln 
            180                 185                 190         


Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu 
        195                 200                 205             


Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
225                 230                 235                 240 


Ser Ser Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu 
                245                 250                 255     


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            260                 265                 270         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        275                 280                 285             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    290                 295                 300                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
305                 310                 315                 320 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                325                 330                 335     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            340                 345                 350         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        355                 360                 365             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    370                 375                 380                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
385                 390                 395                 400 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                405                 410                 415     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            420                 425                 430         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        435                 440                 445             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    450                 455                 460                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
465                 470                 475                 480 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                485                 490                 495     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            500                 505                 510         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        515                 520                 525             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    530                 535                 540                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
545                 550                 555                 560 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                565                 570                 575     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            580                 585                 590         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        595                 600                 605             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    610                 615                 620                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
625                 630                 635                 640 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                645                 650                 655     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            660                 665                 670         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        675                 680                 685             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    690                 695                 700                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
705                 710                 715                 720 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                725                 730                 735     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            740                 745                 750         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        755                 760                 765             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    770                 775                 780                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
785                 790                 795                 800 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                805                 810                 815     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            820                 825                 830         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        835                 840                 845             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    850                 855                 860                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
865                 870                 875                 880 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                885                 890                 895     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            900                 905                 910         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        915                 920                 925             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    930                 935                 940                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
945                 950                 955                 960 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                965                 970                 975     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            980                 985                 990         


Glu Leu Val Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
        995                 1000                 1005             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1010                 1015                 1020             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1025                 1030                 1035             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1040                 1045                 1050             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1055                 1060                 1065             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1070                 1075                 1080             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1085                 1090                 1095             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1100                 1105                 1110             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1115                 1120                 1125             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1130                 1135                 1140             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1145                 1150                 1155             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1160                 1165                 1170             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1175                 1180                 1185             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1190                 1195                 1200             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1205                 1210                 1215             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1220                 1225                 1230             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1235                 1240                 1245             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1250                 1255                 1260             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1265                 1270                 1275             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1280                 1285                 1290             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1295                 1300                 1305             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1310                 1315                 1320             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1325                 1330                 1335             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1340                 1345                 1350             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1355                 1360                 1365             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1370                 1375                 1380             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1385                 1390                 1395             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1400                 1405                 1410             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1415                 1420                 1425             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1430                 1435                 1440             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1445                 1450                 1455             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1460                 1465                 1470             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1475                 1480                 1485             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1490                 1495                 1500             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1505                 1510                 1515             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1520                 1525                 1530             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1535                 1540                 1545             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1550                 1555                 1560             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1565                 1570                 1575             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1580                 1585                 1590             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1595                 1600                 1605             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1610                 1615                 1620             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1625                 1630                 1635             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1640                 1645                 1650             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1655                 1660                 1665             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1670                 1675                 1680             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1685                 1690                 1695             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1700                 1705                 1710             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1715                 1720                 1725             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1730                 1735                 1740             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1745                 1750                 1755             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1760                 1765                 1770             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1775                 1780                 1785             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1790                 1795                 1800             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Lys Arg Thr  Ala Asp Gly 
    1805                 1810                 1815             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1820                 1825                 


<210>  3207
<211>  1829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3207

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp 
            20                  25                  30          


Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys 
        35                  40                  45              


Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Asp Ala Val 
    50                  55                  60                  


Lys Met Asp Gln His Arg Gly Phe Leu His Gly Gln Ala Lys Asn Leu 
65                  70                  75                  80  


Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu 
                85                  90                  95      


Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp 
            100                 105                 110         


Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val 
        115                 120                 125             


Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala 
    130                 135                 140                 


Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met 
145                 150                 155                 160 


Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe 
                165                 170                 175     


Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln 
            180                 185                 190         


Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu 
        195                 200                 205             


Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
225                 230                 235                 240 


Ser Ser Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu 
                245                 250                 255     


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            260                 265                 270         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        275                 280                 285             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    290                 295                 300                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
305                 310                 315                 320 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                325                 330                 335     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            340                 345                 350         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        355                 360                 365             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    370                 375                 380                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
385                 390                 395                 400 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                405                 410                 415     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            420                 425                 430         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        435                 440                 445             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    450                 455                 460                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
465                 470                 475                 480 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                485                 490                 495     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            500                 505                 510         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        515                 520                 525             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    530                 535                 540                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
545                 550                 555                 560 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                565                 570                 575     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            580                 585                 590         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        595                 600                 605             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    610                 615                 620                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
625                 630                 635                 640 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                645                 650                 655     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            660                 665                 670         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        675                 680                 685             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    690                 695                 700                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
705                 710                 715                 720 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                725                 730                 735     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            740                 745                 750         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        755                 760                 765             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    770                 775                 780                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
785                 790                 795                 800 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                805                 810                 815     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            820                 825                 830         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        835                 840                 845             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    850                 855                 860                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
865                 870                 875                 880 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                885                 890                 895     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            900                 905                 910         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        915                 920                 925             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    930                 935                 940                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
945                 950                 955                 960 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                965                 970                 975     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            980                 985                 990         


Glu Leu Val Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
        995                 1000                 1005             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1010                 1015                 1020             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1025                 1030                 1035             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1040                 1045                 1050             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1055                 1060                 1065             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1070                 1075                 1080             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1085                 1090                 1095             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1100                 1105                 1110             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1115                 1120                 1125             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1130                 1135                 1140             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1145                 1150                 1155             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1160                 1165                 1170             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1175                 1180                 1185             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1190                 1195                 1200             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1205                 1210                 1215             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1220                 1225                 1230             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1235                 1240                 1245             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1250                 1255                 1260             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1265                 1270                 1275             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1280                 1285                 1290             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1295                 1300                 1305             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1310                 1315                 1320             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1325                 1330                 1335             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1340                 1345                 1350             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1355                 1360                 1365             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1370                 1375                 1380             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1385                 1390                 1395             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1400                 1405                 1410             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1415                 1420                 1425             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1430                 1435                 1440             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1445                 1450                 1455             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1460                 1465                 1470             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1475                 1480                 1485             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1490                 1495                 1500             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1505                 1510                 1515             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1520                 1525                 1530             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1535                 1540                 1545             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1550                 1555                 1560             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1565                 1570                 1575             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1580                 1585                 1590             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1595                 1600                 1605             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1610                 1615                 1620             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1625                 1630                 1635             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1640                 1645                 1650             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1655                 1660                 1665             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1670                 1675                 1680             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1685                 1690                 1695             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1700                 1705                 1710             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1715                 1720                 1725             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1730                 1735                 1740             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1745                 1750                 1755             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1760                 1765                 1770             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1775                 1780                 1785             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1790                 1795                 1800             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Lys Arg Thr  Ala Asp Gly 
    1805                 1810                 1815             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1820                 1825                 


<210>  3208
<211>  1880
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3208

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe 
        275                 280                 285             


Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 
    290                 295                 300                 


Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr 
305                 310                 315                 320 


Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys 
                325                 330                 335     


Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln 
            340                 345                 350         


Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp 
        355                 360                 365             


Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly 
    370                 375                 380                 


Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val 
385                 390                 395                 400 


Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly 
                405                 410                 415     


Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe 
            420                 425                 430         


Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys 
        435                 440                 445             


Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met 
    450                 455                 460                 


Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro 
465                 470                 475                 480 


Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu 
                485                 490                 495     


Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln 
            500                 505                 510         


His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser 
        515                 520                 525             


Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 
    530                 535                 540                 


Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile 
545                 550                 555                 560 


Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys 
                565                 570                 575     


Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu 
            580                 585                 590         


Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu 
        595                 600                 605             


Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met 
625                 630                 635                 640 


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
                645                 650                 655     


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            660                 665                 670         


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        675                 680                 685             


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    690                 695                 700                 


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
705                 710                 715                 720 


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                725                 730                 735     


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            740                 745                 750         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        755                 760                 765             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    770                 775                 780                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
785                 790                 795                 800 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                805                 810                 815     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            820                 825                 830         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        835                 840                 845             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    850                 855                 860                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
865                 870                 875                 880 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                885                 890                 895     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            900                 905                 910         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        915                 920                 925             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    930                 935                 940                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
945                 950                 955                 960 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                965                 970                 975     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            980                 985                 990         


Gln Ser Lys Asn Gly Tyr Ala Gly  Tyr Ile Asp Gly Gly  Ala Ser Gln 
        995                 1000                 1005             


Glu Glu  Phe Tyr Lys Phe Ile  Lys Pro Ile Leu Glu  Lys Met Asp 
    1010                 1015                 1020             


Gly Thr  Glu Glu Leu Leu Val  Lys Leu Asn Arg Glu  Asp Leu Leu 
    1025                 1030                 1035             


Arg Lys  Gln Arg Thr Phe Asp  Asn Gly Ser Ile Pro  His Gln Ile 
    1040                 1045                 1050             


His Leu  Gly Glu Leu His Ala  Ile Leu Arg Arg Gln  Glu Asp Phe 
    1055                 1060                 1065             


Tyr Pro  Phe Leu Lys Asp Asn  Arg Glu Lys Ile Glu  Lys Ile Leu 
    1070                 1075                 1080             


Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro Leu Ala  Arg Gly Asn 
    1085                 1090                 1095             


Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser Glu Glu  Thr Ile Thr 
    1100                 1105                 1110             


Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys Gly Ala  Ser Ala Gln 
    1115                 1120                 1125             


Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp Lys Asn  Leu Pro Asn 
    1130                 1135                 1140             


Glu Lys  Val Leu Pro Lys His  Ser Leu Leu Tyr Glu  Tyr Phe Thr 
    1145                 1150                 1155             


Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr Val Thr  Glu Gly Met 
    1160                 1165                 1170             


Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln Lys Lys  Ala Ile Val 
    1175                 1180                 1185             


Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val Thr Val  Lys Gln Leu 
    1190                 1195                 1200             


Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys Phe Asp  Ser Val Glu 
    1205                 1210                 1215             


Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
    1220                 1225                 1230             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1235                 1240                 1245             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1250                 1255                 1260             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1265                 1270                 1275             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1280                 1285                 1290             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1295                 1300                 1305             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1310                 1315                 1320             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1325                 1330                 1335             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1340                 1345                 1350             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1355                 1360                 1365             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1370                 1375                 1380             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1385                 1390                 1395             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1400                 1405                 1410             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1415                 1420                 1425             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1430                 1435                 1440             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1445                 1450                 1455             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1460                 1465                 1470             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1475                 1480                 1485             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1490                 1495                 1500             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1505                 1510                 1515             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1520                 1525                 1530             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1535                 1540                 1545             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1550                 1555                 1560             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1565                 1570                 1575             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1580                 1585                 1590             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1595                 1600                 1605             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1610                 1615                 1620             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1625                 1630                 1635             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1640                 1645                 1650             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Ser Gly 
    1655                 1660                 1665             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1670                 1675                 1680             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1685                 1690                 1695             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1700                 1705                 1710             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1715                 1720                 1725             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1730                 1735                 1740             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1745                 1750                 1755             


Leu Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1760                 1765                 1770             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1775                 1780                 1785             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1790                 1795                 1800             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1805                 1810                 1815             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1820                 1825                 1830             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1835                 1840                 1845             


Ile Lys  Met Leu Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1850                 1855                 1860             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    1865                 1870                 1875             


Lys Val  
    1880 


<210>  3209
<211>  1859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3209

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile 
        275                 280                 285             


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val 
    290                 295                 300                 


Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile 
305                 310                 315                 320 


Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala 
                325                 330                 335     


Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
            340                 345                 350         


Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala 
        355                 360                 365             


Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val 
    370                 375                 380                 


Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val 
385                 390                 395                 400 


Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg 
                405                 410                 415     


Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr 
            420                 425                 430         


Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu 
        435                 440                 445             


Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln 
    450                 455                 460                 


Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala 
465                 470                 475                 480 


Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser 
                485                 490                 495     


Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn 
            500                 505                 510         


Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn 
        515                 520                 525             


Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser 
    530                 535                 540                 


Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly 
545                 550                 555                 560 


Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala 
                565                 570                 575     


Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala 
            580                 585                 590         


Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp 
        595                 600                 605             


Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr 
    610                 615                 620                 


Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile 
625                 630                 635                 640 


Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile 
                645                 650                 655     


Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg 
            660                 665                 670         


Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
        675                 680                 685             


His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu 
    690                 695                 700                 


Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile 
705                 710                 715                 720 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
                725                 730                 735     


Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro 
            740                 745                 750         


Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe 
        755                 760                 765             


Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val 
    770                 775                 780                 


Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu 
785                 790                 795                 800 


Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe 
                805                 810                 815     


Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr 
            820                 825                 830         


Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys 
        835                 840                 845             


Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe 
    850                 855                 860                 


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp 
865                 870                 875                 880 


Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile 
                885                 890                 895     


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg 
            900                 905                 910         


Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu 
        915                 920                 925             


Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile 
    930                 935                 940                 


Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu 
945                 950                 955                 960 


Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp 
                965                 970                 975     


Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly 
            980                 985                 990         


Gln Gly Asp Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
        995                 1000                 1005             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1010                 1015                 1020             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1025                 1030                 1035             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1040                 1045                 1050             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1055                 1060                 1065             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1070                 1075                 1080             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1085                 1090                 1095             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1100                 1105                 1110             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1115                 1120                 1125             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1130                 1135                 1140             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1145                 1150                 1155             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1160                 1165                 1170             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1175                 1180                 1185             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1190                 1195                 1200             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1205                 1210                 1215             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1220                 1225                 1230             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1235                 1240                 1245             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1250                 1255                 1260             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1265                 1270                 1275             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1280                 1285                 1290             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1295                 1300                 1305             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1310                 1315                 1320             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1325                 1330                 1335             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1340                 1345                 1350             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1355                 1360                 1365             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1370                 1375                 1380             


Lys Glu  Ser Ile Arg Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1385                 1390                 1395             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Val Ser 
    1400                 1405                 1410             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1415                 1420                 1425             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1430                 1435                 1440             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1445                 1450                 1455             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1460                 1465                 1470             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1475                 1480                 1485             


Arg Met  Leu Ala Ser Ala Arg  Phe Leu Gln Lys Gly  Asn Glu Leu 
    1490                 1495                 1500             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1505                 1510                 1515             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1520                 1525                 1530             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1535                 1540                 1545             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1550                 1555                 1560             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1565                 1570                 1575             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1580                 1585                 1590             


Asn Leu  Gly Ala Pro Arg Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1595                 1600                 1605             


Asp Arg  Lys Val Tyr Arg Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1610                 1615                 1620             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1625                 1630                 1635             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1640                 1645                 1650             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1655                 1660                 1665             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1670                 1675                 1680             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1685                 1690                 1695             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1700                 1705                 1710             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1715                 1720                 1725             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1730                 1735                 1740             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1745                 1750                 1755             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1760                 1765                 1770             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1775                 1780                 1785             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1790                 1795                 1800             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1805                 1810                 1815             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1820                 1825                 1830             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Lys Arg Thr  Ala Asp Gly 
    1835                 1840                 1845             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    1850                 1855                 


<210>  3210
<211>  1996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3210

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Gly 
    1775                 1780                 1785             


Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1790                 1795                 1800             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1805                 1810                 1815             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1820                 1825                 1830             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1835                 1840                 1845             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1850                 1855                 1860             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly 
    1865                 1870                 1875             


Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu 
    1880                 1885                 1890             


Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met 
    1895                 1900                 1905             


Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser 
    1910                 1915                 1920             


Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn 
    1925                 1930                 1935             


Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala 
    1940                 1945                 1950             


Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu 
    1955                 1960                 1965             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val Lys  Arg Thr Ala 
    1970                 1975                 1980             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1985                 1990                 1995     


<210>  3211
<211>  2016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3211

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn 
                405                 410                 415     


Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile 
            420                 425                 430         


Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val 
        435                 440                 445             


Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met 
    450                 455                 460                 


Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe 
465                 470                 475                 480 


Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala 
                485                 490                 495     


Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro 
            500                 505                 510         


Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys 
        515                 520                 525             


Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met 
    530                 535                 540                 


Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys 
545                 550                 555                 560 


Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr 
                565                 570                 575     


Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala 
            580                 585                 590         


Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 
        595                 600                 605             


Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 
    610                 615                 620                 


Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr 
625                 630                 635                 640 


Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile 
                645                 650                 655     


Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His 
            660                 665                 670         


Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe 
        675                 680                 685             


Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr 
    690                 695                 700                 


Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala 
705                 710                 715                 720 


Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 
                725                 730                 735     


Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            740                 745                 750         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser 
        755                 760                 765             


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
    770                 775                 780                 


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
785                 790                 795                 800 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
                805                 810                 815     


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
            820                 825                 830         


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
        835                 840                 845             


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
    850                 855                 860                 


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
865                 870                 875                 880 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
                885                 890                 895     


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
            900                 905                 910         


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
        915                 920                 925             


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
    930                 935                 940                 


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
945                 950                 955                 960 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
                965                 970                 975     


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
            980                 985                 990         


Gly Glu Lys Lys Asn Gly Leu Phe  Gly Asn Leu Ile Ala  Leu Ser Leu 
        995                 1000                 1005             


Gly Leu  Thr Pro Asn Phe Lys  Ser Asn Phe Asp Leu  Ala Glu Asp 
    1010                 1015                 1020             


Ala Lys  Leu Gln Leu Ser Lys  Asp Thr Tyr Asp Asp  Asp Leu Asp 
    1025                 1030                 1035             


Asn Leu  Leu Ala Gln Ile Gly  Asp Gln Tyr Ala Asp  Leu Phe Leu 
    1040                 1045                 1050             


Ala Ala  Lys Asn Leu Ser Asp  Ala Ile Leu Leu Ser  Asp Ile Leu 
    1055                 1060                 1065             


Arg Val  Asn Thr Glu Ile Thr  Lys Ala Pro Leu Ser  Ala Ser Met 
    1070                 1075                 1080             


Ile Lys  Arg Tyr Asp Glu His  His Gln Asp Leu Thr  Leu Leu Lys 
    1085                 1090                 1095             


Ala Leu  Val Arg Gln Gln Leu  Pro Glu Lys Tyr Lys  Glu Ile Phe 
    1100                 1105                 1110             


Phe Asp  Gln Ser Lys Asn Gly  Tyr Ala Gly Tyr Ile  Asp Gly Gly 
    1115                 1120                 1125             


Ala Ser  Gln Glu Glu Phe Tyr  Lys Phe Ile Lys Pro  Ile Leu Glu 
    1130                 1135                 1140             


Lys Met  Asp Gly Thr Glu Glu  Leu Leu Val Lys Leu  Asn Arg Glu 
    1145                 1150                 1155             


Asp Leu  Leu Arg Lys Gln Arg  Thr Phe Asp Asn Gly  Ser Ile Pro 
    1160                 1165                 1170             


His Gln  Ile His Leu Gly Glu  Leu His Ala Ile Leu  Arg Arg Gln 
    1175                 1180                 1185             


Glu Asp  Phe Tyr Pro Phe Leu  Lys Asp Asn Arg Glu  Lys Ile Glu 
    1190                 1195                 1200             


Lys Ile  Leu Thr Phe Arg Ile  Pro Tyr Tyr Val Gly  Pro Leu Ala 
    1205                 1210                 1215             


Arg Gly  Asn Ser Arg Phe Ala  Trp Met Thr Arg Lys  Ser Glu Glu 
    1220                 1225                 1230             


Thr Ile  Thr Pro Trp Asn Phe  Glu Glu Val Val Asp  Lys Gly Ala 
    1235                 1240                 1245             


Ser Ala  Gln Ser Phe Ile Glu  Arg Met Thr Asn Phe  Asp Lys Asn 
    1250                 1255                 1260             


Leu Pro  Asn Glu Lys Val Leu  Pro Lys His Ser Leu  Leu Tyr Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Val Tyr Asn Glu  Leu Thr Lys Val Lys  Tyr Val Thr 
    1280                 1285                 1290             


Glu Gly  Met Arg Lys Pro Ala  Phe Leu Ser Gly Glu  Gln Lys Lys 
    1295                 1300                 1305             


Ala Ile  Val Asp Leu Leu Phe  Lys Thr Asn Arg Lys  Val Thr Val 
    1310                 1315                 1320             


Lys Gln  Leu Lys Glu Asp Tyr  Phe Lys Lys Ile Glu  Cys Phe Asp 
    1325                 1330                 1335             


Ser Val  Glu Ile Ser Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu 
    1340                 1345                 1350             


Gly Thr  Tyr His Asp Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe 
    1355                 1360                 1365             


Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu 
    1370                 1375                 1380             


Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu 
    1385                 1390                 1395             


Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu 
    1400                 1405                 1410             


Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu 
    1415                 1420                 1425             


Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp 
    1430                 1435                 1440             


Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu 
    1445                 1450                 1455             


Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala 
    1460                 1465                 1470             


Gln Val  Ser Gly Gln Gly Asp  Ser Leu His Glu His  Ile Ala Asn 
    1475                 1480                 1485             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1490                 1495                 1500             


Lys Val  Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
    1505                 1510                 1515             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1520                 1525                 1530             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1535                 1540                 1545             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1550                 1555                 1560             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1565                 1570                 1575             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1580                 1585                 1590             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1595                 1600                 1605             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1610                 1615                 1620             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1625                 1630                 1635             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1640                 1645                 1650             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1655                 1660                 1665             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1670                 1675                 1680             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1685                 1690                 1695             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1700                 1705                 1710             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1715                 1720                 1725             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1730                 1735                 1740             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1745                 1750                 1755             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1760                 1765                 1770             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1775                 1780                 1785             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Ser 
    1790                 1795                 1800             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1805                 1810                 1815             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1820                 1825                 1830             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1835                 1840                 1845             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1850                 1855                 1860             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1865                 1870                 1875             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1880                 1885                 1890             


Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu 
    1895                 1900                 1905             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1910                 1915                 1920             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1925                 1930                 1935             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1940                 1945                 1950             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1955                 1960                 1965             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1970                 1975                 1980             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1985                 1990                 1995             


Val Lys  Arg Thr Ala Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys 
    2000                 2005                 2010             


Arg Lys  Val 
    2015     


<210>  3212

<400>  3212
000

<210>  3213
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3213
gagtcctaga gtgttatctt taggcacgat acaggtacat gaatccgctc atctaggtga       60

cctactcctg ccctggtagc agccttaatg acgatcgttg                            100


<210>  3214
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3214
gcacgataca ggtacatgaa                                                   20


<210>  3215
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3215
tatagcatat ttattacatc gg                                                22


<210>  3216
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3216
ccgtcatgtg ggtcctgaat tgg                                               23


<210>  3217
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3217
acactgaaag actccaggtc agg                                               23


<210>  3218
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3218
tttaaagtga agcagcatct ggg                                               23


<210>  3219
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3219
atttaaagtg aagcagcatc tgg                                               23


<210>  3220
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3220
actccatgac agtgtaattt tgg                                               23


<210>  3221
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3221
gcctggagaa gccatccagc agg                                               23


<210>  3222
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3222
ctcagacaca ctcattgatg agg                                               23


<210>  3223
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3223
gaggcactgc ccccaccatg agcg                                              24


<210>  3224
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3224
caccgtggtt tacaccgaca                                                   20


<210>  3225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3225
cttccatggg ggccatgagg                                                   20


<210>  3226
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3226
gtgtgacact gatatccgca                                                   20


<210>  3227
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3227
ctacccgtta aagaatcatc                                                   20


<210>  3228
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3228
tgtagcaggt gaagatgatc                                                   20


<210>  3229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3229
cttgcgttat gatggattca                                                   20


<210>  3230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3230
gaatttgccg gtgaccgggg                                                   20


<210>  3231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3231
atgtgacgga agaggttgaa                                                   20


<210>  3232
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3232
ggagcagggg ctcagcaggg                                                   20


<210>  3233
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3233
caaggatccg gaggaggtga                                                   20


<210>  3234
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3234
atgtcggagg cttggaactc                                                   20


<210>  3235
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3235
gaggttcctt gagtcctttg                                                   20


<210>  3236
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3236
tgaacgcaga ttcttgttct                                                   20


<210>  3237
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3237
gttcactgat agcaggaagg                                                   20


<210>  3238
<211>  171
<212>  PRT
<213>  Streptococcus pyogenes

<400>  3238

Met Pro Tyr Ser Leu Glu Glu Gln Thr Tyr Phe Met Gln Glu Ala Leu 
1               5                   10                  15      


Lys Glu Ala Glu Lys Ser Leu Gln Lys Ala Glu Ile Pro Ile Gly Cys 
            20                  25                  30          


Val Ile Val Lys Asp Gly Glu Ile Ile Gly Arg Gly His Asn Ala Arg 
        35                  40                  45              


Glu Glu Ser Asn Gln Ala Ile Met His Ala Glu Ile Met Ala Ile Asn 
    50                  55                  60                  


Glu Ala Asn Ala His Glu Gly Asn Trp Arg Leu Leu Asp Thr Thr Leu 
65                  70                  75                  80  


Phe Val Thr Ile Glu Pro Cys Val Met Cys Ser Gly Ala Ile Gly Leu 
                85                  90                  95      


Ala Arg Ile Pro His Val Ile Tyr Gly Ala Ser Asn Gln Lys Phe Gly 
            100                 105                 110         


Gly Ala Asp Ser Leu Tyr Gln Ile Leu Thr Asp Glu Arg Leu Asn His 
        115                 120                 125             


Arg Val Gln Val Glu Arg Gly Leu Leu Ala Ala Asp Cys Ala Asn Ile 
    130                 135                 140                 


Met Gln Thr Phe Phe Arg Gln Gly Arg Glu Arg Lys Lys Ile Ala Lys 
145                 150                 155                 160 


His Leu Ile Lys Glu Gln Ser Asp Pro Phe Asp 
                165                 170     


<210>  3239
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3239

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  3240
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3240

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Val 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Leu 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Cys Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Ile Lys Val Met  Gly Gly His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Glu Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Ala Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asn Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Ser Val Leu His  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Ser Glu Asp  Asn Lys Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Ser  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Gly Arg Lys Leu Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  3241
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3241

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ile Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Leu Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Cys Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Ile Lys Val Met Gly Gly His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Glu Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Ala Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Gly  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asn Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Gly Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Ser Val  Leu His Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Ser  Glu Asp Asn Lys Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Ser Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Gly 
    1535                 1540                 1545             


Arg Lys  Leu Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  3242
<211>  1795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3242

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Ile Gln  Thr Val Gly 
    1505                 1510                 1515             


Gln Asn  Gly Gly Leu Phe Asp  Asp Asn Pro Lys Ser  Pro Leu Glu 
    1520                 1525                 1530             


Val Thr  Pro Ser Lys Leu Val  Pro Leu Lys Lys Glu  Leu Asn Pro 
    1535                 1540                 1545             


Lys Lys  Tyr Gly Gly Tyr Gln  Lys Pro Thr Thr Ala  Tyr Pro Val 
    1550                 1555                 1560             


Leu Leu  Ile Thr Asp Thr Lys  Gln Leu Ile Pro Ile  Ser Val Met 
    1565                 1570                 1575             


Asn Lys  Lys Gln Phe Glu Gln  Asn Pro Val Lys Phe  Leu Arg Asp 
    1580                 1585                 1590             


Arg Gly  Tyr Gln Gln Val Gly  Lys Asn Asp Phe Ile  Lys Leu Pro 
    1595                 1600                 1605             


Lys Tyr  Thr Leu Val Asp Ile  Gly Asp Gly Ile Lys  Arg Leu Trp 
    1610                 1615                 1620             


Ala Ser  Ser Lys Glu Ile His  Lys Gly Asn Gln Leu  Val Val Ser 
    1625                 1630                 1635             


Lys Lys  Ser Gln Ile Leu Leu  Tyr His Ala His His  Leu Asp Ser 
    1640                 1645                 1650             


Asp Leu  Ser Asn Asp Tyr Leu  Gln Asn His Asn Gln  Gln Phe Asp 
    1655                 1660                 1665             


Val Leu  Phe Asn Glu Ile Ile  Ser Phe Ser Lys Lys  Cys Lys Leu 
    1670                 1675                 1680             


Gly Lys  Glu His Ile Gln Lys  Ile Glu Asn Val Tyr  Ser Asn Lys 
    1685                 1690                 1695             


Lys Asn  Ser Ala Ser Ile Glu  Glu Leu Ala Glu Ser  Phe Ile Lys 
    1700                 1705                 1710             


Leu Leu  Gly Phe Thr Gln Leu  Gly Ala Thr Ser Pro  Phe Asn Phe 
    1715                 1720                 1725             


Leu Gly  Val Lys Leu Asn Gln  Lys Gln Tyr Lys Gly  Lys Lys Asp 
    1730                 1735                 1740             


Tyr Ile  Leu Pro Cys Thr Glu  Gly Thr Leu Ile Arg  Gln Ser Ile 
    1745                 1750                 1755             


Thr Gly  Leu Tyr Glu Thr Arg  Val Asp Leu Ser Lys  Ile Gly Glu 
    1760                 1765                 1770             


Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1775                 1780                 1785             


Pro Lys  Lys Lys Arg Lys Val  
    1790                 1795 


<210>  3243
<211>  1597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3243

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Thr Val Gly  Gln Asn Gly 
    1310                 1315                 1320             


Gly Leu  Phe Asp Asp Asn Pro  Lys Ser Pro Leu Glu  Val Thr Pro 
    1325                 1330                 1335             


Ser Lys  Leu Val Pro Leu Lys  Lys Glu Leu Asn Pro  Lys Lys Tyr 
    1340                 1345                 1350             


Gly Gly  Tyr Gln Lys Pro Thr  Thr Ala Tyr Pro Val  Leu Leu Ile 
    1355                 1360                 1365             


Thr Asp  Thr Lys Gln Leu Ile  Pro Ile Ser Val Met  Asn Lys Lys 
    1370                 1375                 1380             


Gln Phe  Glu Gln Asn Pro Val  Lys Phe Leu Arg Asp  Arg Gly Tyr 
    1385                 1390                 1395             


Gln Gln  Val Gly Lys Asn Asp  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1400                 1405                 1410             


Leu Val  Asp Ile Gly Asp Gly  Ile Lys Arg Leu Trp  Ala Ser Ser 
    1415                 1420                 1425             


Lys Glu  Ile His Lys Gly Asn  Gln Leu Val Val Ser  Lys Lys Ser 
    1430                 1435                 1440             


Gln Ile  Leu Leu Tyr His Ala  His His Leu Asp Ser  Asp Leu Ser 
    1445                 1450                 1455             


Asn Asp  Tyr Leu Gln Asn His  Asn Gln Gln Phe Asp  Val Leu Phe 
    1460                 1465                 1470             


Asn Glu  Ile Ile Ser Phe Ser  Lys Lys Cys Lys Leu  Gly Lys Glu 
    1475                 1480                 1485             


His Ile  Gln Lys Ile Glu Asn  Val Tyr Ser Asn Lys  Lys Asn Ser 
    1490                 1495                 1500             


Ala Ser  Ile Glu Glu Leu Ala  Glu Ser Phe Ile Lys  Leu Leu Gly 
    1505                 1510                 1515             


Phe Thr  Gln Leu Gly Ala Thr  Ser Pro Phe Asn Phe  Leu Gly Val 
    1520                 1525                 1530             


Lys Leu  Asn Gln Lys Gln Tyr  Lys Gly Lys Lys Asp  Tyr Ile Leu 
    1535                 1540                 1545             


Pro Cys  Thr Glu Gly Thr Leu  Ile Arg Gln Ser Ile  Thr Gly Leu 
    1550                 1555                 1560             


Tyr Glu  Thr Arg Val Asp Leu  Ser Lys Ile Gly Glu  Asp Ser Gly 
    1565                 1570                 1575             


Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys 
    1580                 1585                 1590             


Lys Arg  Lys Val 
    1595         


<210>  3244
<211>  1823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3244

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn 
                405                 410                 415     


Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile 
            420                 425                 430         


Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val 
        435                 440                 445             


Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met 
    450                 455                 460                 


Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe 
465                 470                 475                 480 


Ser Lys Glu Ser Ile Arg Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala 
                485                 490                 495     


Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Val Ser Pro 
            500                 505                 510         


Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys 
        515                 520                 525             


Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met 
    530                 535                 540                 


Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys 
545                 550                 555                 560 


Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr 
                565                 570                 575     


Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala 
            580                 585                 590         


Arg Phe Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 
        595                 600                 605             


Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 
    610                 615                 620                 


Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr 
625                 630                 635                 640 


Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile 
                645                 650                 655     


Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His 
            660                 665                 670         


Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe 
        675                 680                 685             


Thr Leu Thr Asn Leu Gly Ala Pro Arg Ala Phe Lys Tyr Phe Asp Thr 
    690                 695                 700                 


Thr Ile Asp Arg Lys Val Tyr Arg Ser Thr Lys Glu Val Leu Asp Ala 
705                 710                 715                 720 


Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 
                725                 730                 735     


Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            740                 745                 750         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser 
        755                 760                 765             


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
    770                 775                 780                 


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
785                 790                 795                 800 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
                805                 810                 815     


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
            820                 825                 830         


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
        835                 840                 845             


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
    850                 855                 860                 


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
865                 870                 875                 880 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
                885                 890                 895     


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
            900                 905                 910         


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
        915                 920                 925             


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
    930                 935                 940                 


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
945                 950                 955                 960 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
                965                 970                 975     


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
            980                 985                 990         


Gly Glu Lys Lys Asn Gly Leu Phe  Gly Asn Leu Ile Ala  Leu Ser Leu 
        995                 1000                 1005             


Gly Leu  Thr Pro Asn Phe Lys  Ser Asn Phe Asp Leu  Ala Glu Asp 
    1010                 1015                 1020             


Ala Lys  Leu Gln Leu Ser Lys  Asp Thr Tyr Asp Asp  Asp Leu Asp 
    1025                 1030                 1035             


Asn Leu  Leu Ala Gln Ile Gly  Asp Gln Tyr Ala Asp  Leu Phe Leu 
    1040                 1045                 1050             


Ala Ala  Lys Asn Leu Ser Asp  Ala Ile Leu Leu Ser  Asp Ile Leu 
    1055                 1060                 1065             


Arg Val  Asn Thr Glu Ile Thr  Lys Ala Pro Leu Ser  Ala Ser Met 
    1070                 1075                 1080             


Ile Lys  Arg Tyr Asp Glu His  His Gln Asp Leu Thr  Leu Leu Lys 
    1085                 1090                 1095             


Ala Leu  Val Arg Gln Gln Leu  Pro Glu Lys Tyr Lys  Glu Ile Phe 
    1100                 1105                 1110             


Phe Asp  Gln Ser Lys Asn Gly  Tyr Ala Gly Tyr Ile  Asp Gly Gly 
    1115                 1120                 1125             


Ala Ser  Gln Glu Glu Phe Tyr  Lys Phe Ile Lys Pro  Ile Leu Glu 
    1130                 1135                 1140             


Lys Met  Asp Gly Thr Glu Glu  Leu Leu Val Lys Leu  Asn Arg Glu 
    1145                 1150                 1155             


Asp Leu  Leu Arg Lys Gln Arg  Thr Phe Asp Asn Gly  Ser Ile Pro 
    1160                 1165                 1170             


His Gln  Ile His Leu Gly Glu  Leu His Ala Ile Leu  Arg Arg Gln 
    1175                 1180                 1185             


Glu Asp  Phe Tyr Pro Phe Leu  Lys Asp Asn Arg Glu  Lys Ile Glu 
    1190                 1195                 1200             


Lys Ile  Leu Thr Phe Arg Ile  Pro Tyr Tyr Val Gly  Pro Leu Ala 
    1205                 1210                 1215             


Arg Gly  Asn Ser Arg Phe Ala  Trp Met Thr Arg Lys  Ser Glu Glu 
    1220                 1225                 1230             


Thr Ile  Thr Pro Trp Asn Phe  Glu Glu Val Val Asp  Lys Gly Ala 
    1235                 1240                 1245             


Ser Ala  Gln Ser Phe Ile Glu  Arg Met Thr Asn Phe  Asp Lys Asn 
    1250                 1255                 1260             


Leu Pro  Asn Glu Lys Val Leu  Pro Lys His Ser Leu  Leu Tyr Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Val Tyr Asn Glu  Leu Thr Lys Val Lys  Tyr Val Thr 
    1280                 1285                 1290             


Glu Gly  Met Arg Lys Pro Ala  Phe Leu Ser Gly Glu  Gln Lys Lys 
    1295                 1300                 1305             


Ala Ile  Val Asp Leu Leu Phe  Lys Thr Asn Arg Lys  Val Thr Val 
    1310                 1315                 1320             


Lys Gln  Leu Lys Glu Asp Tyr  Phe Lys Lys Ile Glu  Cys Phe Asp 
    1325                 1330                 1335             


Ser Val  Glu Ile Ser Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu 
    1340                 1345                 1350             


Gly Thr  Tyr His Asp Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe 
    1355                 1360                 1365             


Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu 
    1370                 1375                 1380             


Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu 
    1385                 1390                 1395             


Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu 
    1400                 1405                 1410             


Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu 
    1415                 1420                 1425             


Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp 
    1430                 1435                 1440             


Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu 
    1445                 1450                 1455             


Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala 
    1460                 1465                 1470             


Gln Val  Ser Gly Gln Gly Asp  Ser Leu His Glu His  Ile Ala Asn 
    1475                 1480                 1485             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1490                 1495                 1500             


Lys Val  Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
    1505                 1510                 1515             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1520                 1525                 1530             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1535                 1540                 1545             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1550                 1555                 1560             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1565                 1570                 1575             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1580                 1585                 1590             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1595                 1600                 1605             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1610                 1615                 1620             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1625                 1630                 1635             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1640                 1645                 1650             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1655                 1660                 1665             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1670                 1675                 1680             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1685                 1690                 1695             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1700                 1705                 1710             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1715                 1720                 1725             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1730                 1735                 1740             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1745                 1750                 1755             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1760                 1765                 1770             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1775                 1780                 1785             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Ser 
    1790                 1795                 1800             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1805                 1810                 1815             


Lys Lys  Arg Lys Val 
    1820             


<210>  3245
<211>  1625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3245

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Ile Met Asn Phe Phe Lys 
    210                 215                 220                 


Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile 
225                 230                 235                 240 


Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp 
                245                 250                 255     


Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val 
            260                 265                 270         


Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Arg 
        275                 280                 285             


Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp 
    290                 295                 300                 


Pro Lys Lys Tyr Gly Gly Phe Val Ser Pro Thr Val Ala Tyr Ser Val 
305                 310                 315                 320 


Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser 
                325                 330                 335     


Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu 
            340                 345                 350         


Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys 
        355                 360                 365             


Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu 
    370                 375                 380                 


Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Arg Phe Leu Gln Lys Gly 
385                 390                 395                 400 


Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala 
                405                 410                 415     


Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys 
            420                 425                 430         


Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu 
        435                 440                 445             


Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu 
    450                 455                 460                 


Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg 
465                 470                 475                 480 


Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly 
                485                 490                 495     


Ala Pro Arg Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Val 
            500                 505                 510         


Tyr Arg Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser 
        515                 520                 525             


Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly 
    530                 535                 540                 


Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                565                 570                 575     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            580                 585                 590         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        595                 600                 605             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    610                 615                 620                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
625                 630                 635                 640 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                645                 650                 655     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            660                 665                 670         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        675                 680                 685             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    690                 695                 700                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
705                 710                 715                 720 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                725                 730                 735     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            740                 745                 750         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        755                 760                 765             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    770                 775                 780                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
785                 790                 795                 800 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                805                 810                 815     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            820                 825                 830         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        835                 840                 845             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    850                 855                 860                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
865                 870                 875                 880 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                885                 890                 895     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            900                 905                 910         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        915                 920                 925             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    930                 935                 940                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
945                 950                 955                 960 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                965                 970                 975     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            980                 985                 990         


Phe Tyr Pro Phe Leu Lys Asp Asn  Arg Glu Lys Ile Glu  Lys Ile Leu 
        995                 1000                 1005             


Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro Leu Ala  Arg Gly Asn 
    1010                 1015                 1020             


Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser Glu Glu  Thr Ile Thr 
    1025                 1030                 1035             


Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys Gly Ala  Ser Ala Gln 
    1040                 1045                 1050             


Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp Lys Asn  Leu Pro Asn 
    1055                 1060                 1065             


Glu Lys  Val Leu Pro Lys His  Ser Leu Leu Tyr Glu  Tyr Phe Thr 
    1070                 1075                 1080             


Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr Val Thr  Glu Gly Met 
    1085                 1090                 1095             


Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln Lys Lys  Ala Ile Val 
    1100                 1105                 1110             


Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val Thr Val  Lys Gln Leu 
    1115                 1120                 1125             


Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys Phe Asp  Ser Val Glu 
    1130                 1135                 1140             


Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
    1145                 1150                 1155             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1160                 1165                 1170             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1175                 1180                 1185             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1190                 1195                 1200             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1205                 1210                 1215             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1220                 1225                 1230             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1235                 1240                 1245             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1250                 1255                 1260             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1265                 1270                 1275             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1280                 1285                 1290             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1295                 1300                 1305             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1310                 1315                 1320             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1325                 1330                 1335             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1340                 1345                 1350             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1355                 1360                 1365             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1370                 1375                 1380             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1385                 1390                 1395             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1400                 1405                 1410             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1415                 1420                 1425             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1430                 1435                 1440             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1445                 1450                 1455             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1460                 1465                 1470             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1475                 1480                 1485             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1490                 1495                 1500             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1505                 1510                 1515             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1520                 1525                 1530             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1535                 1540                 1545             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1550                 1555                 1560             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1565                 1570                 1575             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1580                 1585                 1590             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Ser  Gly Gly Ser 
    1595                 1600                 1605             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg 
    1610                 1615                 1620             


Lys Val  
    1625 


<210>  3246
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3246

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Val 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Leu 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Cys Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Ile Lys Val Met  Gly Gly His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Glu Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Ala Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asn Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Val Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asn Arg Lys Gln Tyr  Asn Thr Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile Arg Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  3247
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3247

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ile Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Leu Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Cys Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Ile Lys Val Met Gly Gly His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Glu Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Ala Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Gly  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asn Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Val  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asn 
    1535                 1540                 1545             


Arg Lys  Gln Tyr Asn Thr Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile Arg  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  3248
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3248

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Val 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Leu 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Cys Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Ile Lys Val Met  Gly Gly His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Glu Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Ala Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asn Ser  Pro Thr Ala Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Val Leu His  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Val Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Lys Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  3249
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3249

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ile Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Leu Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Cys Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Ile Lys Val Met Gly Gly His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Glu Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Ala Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Gly  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asn Ser Pro 
    1340                 1345                 1350             


Thr Ala  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Gly Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Val  Leu His Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Val Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Lys Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  3250
<211>  1489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3250

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly 
                405                 410                 415     


Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val Gly 
            420                 425                 430         


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
        435                 440                 445             


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
    450                 455                 460                 


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
465                 470                 475                 480 


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
                485                 490                 495     


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
            500                 505                 510         


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
        515                 520                 525             


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
    530                 535                 540                 


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
545                 550                 555                 560 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
                565                 570                 575     


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
            580                 585                 590         


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
        595                 600                 605             


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
    610                 615                 620                 


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
625                 630                 635                 640 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
                645                 650                 655     


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
            660                 665                 670         


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
        675                 680                 685             


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
    690                 695                 700                 


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
705                 710                 715                 720 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
                725                 730                 735     


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
            740                 745                 750         


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
        755                 760                 765             


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
    770                 775                 780                 


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
785                 790                 795                 800 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
                805                 810                 815     


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
            820                 825                 830         


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
        835                 840                 845             


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
    850                 855                 860                 


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
865                 870                 875                 880 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
                885                 890                 895     


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
            900                 905                 910         


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
        915                 920                 925             


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
    930                 935                 940                 


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
945                 950                 955                 960 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
                965                 970                 975     


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
            980                 985                 990         


Glu Glu Asn Ser Lys Lys Gly Asn  Arg Thr Pro Phe Gln  Tyr Leu Ser 
        995                 1000                 1005             


Ser Ser  Asp Ser Lys Ile Ser  Tyr Glu Thr Phe Lys  Lys His Ile 
    1010                 1015                 1020             


Leu Asn  Leu Ala Lys Gly Lys  Gly Arg Ile Ser Lys  Thr Lys Lys 
    1025                 1030                 1035             


Glu Tyr  Leu Leu Glu Glu Arg  Asp Ile Asn Arg Phe  Ser Val Gln 
    1040                 1045                 1050             


Lys Asp  Phe Ile Asn Arg Asn  Leu Val Asp Thr Arg  Tyr Ala Thr 
    1055                 1060                 1065             


Arg Gly  Leu Met Asn Leu Leu  Arg Ser Tyr Phe Arg  Val Asn Asn 
    1070                 1075                 1080             


Leu Asp  Val Lys Val Lys Ser  Ile Asn Gly Gly Phe  Thr Ser Phe 
    1085                 1090                 1095             


Leu Arg  Arg Lys Trp Lys Phe  Lys Lys Glu Arg Asn  Lys Gly Tyr 
    1100                 1105                 1110             


Lys His  His Ala Glu Asp Ala  Leu Ile Ile Ala Asn  Ala Asp Phe 
    1115                 1120                 1125             


Ile Phe  Lys Glu Trp Lys Lys  Leu Asp Lys Ala Lys  Lys Val Met 
    1130                 1135                 1140             


Glu Asn  Gln Met Phe Glu Glu  Lys Gln Ala Glu Ser  Met Pro Glu 
    1145                 1150                 1155             


Ile Glu  Thr Glu Gln Glu Tyr  Lys Glu Ile Phe Ile  Thr Pro His 
    1160                 1165                 1170             


Gln Ile  Lys His Ile Lys Asp  Phe Lys Asp Tyr Lys  Tyr Ser His 
    1175                 1180                 1185             


Arg Val  Asp Lys Lys Pro Asn  Arg Lys Leu Ile Asn  Asp Thr Leu 
    1190                 1195                 1200             


Tyr Ser  Thr Arg Lys Asp Asp  Lys Gly Asn Thr Leu  Ile Val Asn 
    1205                 1210                 1215             


Asn Leu  Asn Gly Leu Tyr Asp  Lys Asp Asn Asp Lys  Leu Lys Lys 
    1220                 1225                 1230             


Leu Ile  Asn Lys Ser Pro Glu  Lys Leu Leu Met Tyr  His His Asp 
    1235                 1240                 1245             


Pro Gln  Thr Tyr Gln Lys Leu  Lys Leu Ile Met Glu  Gln Tyr Gly 
    1250                 1255                 1260             


Asp Glu  Lys Asn Pro Leu Tyr  Lys Tyr Tyr Glu Glu  Thr Gly Asn 
    1265                 1270                 1275             


Tyr Leu  Thr Lys Tyr Ser Lys  Lys Asp Asn Gly Pro  Val Ile Lys 
    1280                 1285                 1290             


Lys Ile  Lys Tyr Tyr Gly Asn  Lys Leu Asn Ala His  Leu Asp Ile 
    1295                 1300                 1305             


Thr Asp  Asp Tyr Pro Asn Ser  Arg Asn Lys Val Val  Lys Leu Ser 
    1310                 1315                 1320             


Leu Lys  Pro Tyr Arg Phe Asp  Val Tyr Leu Asp Asn  Gly Val Tyr 
    1325                 1330                 1335             


Lys Phe  Val Thr Val Lys Asn  Leu Asp Val Ile Lys  Lys Glu Asn 
    1340                 1345                 1350             


Tyr Tyr  Glu Val Asn Ser Lys  Cys Tyr Glu Glu Ala  Lys Lys Leu 
    1355                 1360                 1365             


Lys Lys  Ile Ser Asn Gln Ala  Glu Phe Ile Ala Ser  Phe Tyr Lys 
    1370                 1375                 1380             


Asn Asp  Leu Ile Lys Ile Asn  Gly Glu Leu Tyr Arg  Val Ile Gly 
    1385                 1390                 1395             


Val Asn  Asn Asp Leu Leu Asn  Arg Ile Glu Val Asn  Met Ile Asp 
    1400                 1405                 1410             


Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met Asn Asp  Lys Arg Pro 
    1415                 1420                 1425             


Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys Thr Gln  Ser Ile Lys 
    1430                 1435                 1440             


Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu Tyr Glu  Val Lys Ser 
    1445                 1450                 1455             


Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly Ser Gly  Gly Ser Lys 
    1460                 1465                 1470             


Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys 
    1475                 1480                 1485             


Val 
    


<210>  3251
<211>  1291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3251

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu 
    210                 215                 220                 


Gly Leu Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr 
225                 230                 235                 240 


Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala 
                245                 250                 255     


Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg 
            260                 265                 270         


Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu 
        275                 280                 285             


Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn 
    290                 295                 300                 


Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu 
305                 310                 315                 320 


Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His 
                325                 330                 335     


Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys 
            340                 345                 350         


Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala 
        355                 360                 365             


Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser 
    370                 375                 380                 


Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu 
385                 390                 395                 400 


Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp 
                405                 410                 415     


Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro 
            420                 425                 430         


Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu 
        435                 440                 445             


Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val 
    450                 455                 460                 


Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn 
465                 470                 475                 480 


Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu 
                485                 490                 495     


Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr 
            500                 505                 510         


Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys 
        515                 520                 525             


Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys 
    530                 535                 540                 


Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu 
545                 550                 555                 560 


Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln 
                565                 570                 575     


Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu 
            580                 585                 590         


Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly 
        595                 600                 605             


Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu 
    610                 615                 620                 


Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu 
625                 630                 635                 640 


Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr 
                645                 650                 655     


Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile 
            660                 665                 670         


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro 
        675                 680                 685             


Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala 
    690                 695                 700                 


Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu 
705                 710                 715                 720 


Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr 
                725                 730                 735     


Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu 
            740                 745                 750         


Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe 
        755                 760                 765             


Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn 
    770                 775                 780                 


Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys 
785                 790                 795                 800 


Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile 
                805                 810                 815     


Ser Tyr Glu Thr Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys 
            820                 825                 830         


Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp 
        835                 840                 845             


Ile Asn Arg Phe Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val 
    850                 855                 860                 


Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr 
865                 870                 875                 880 


Phe Arg Val Asn Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly 
                885                 890                 895     


Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn 
            900                 905                 910         


Lys Gly Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala 
        915                 920                 925             


Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val 
    930                 935                 940                 


Met Glu Asn Gln Met Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu 
945                 950                 955                 960 


Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile Phe Ile Thr Pro His Gln 
                965                 970                 975     


Ile Lys His Ile Lys Asp Phe Lys Asp Tyr Lys Tyr Ser His Arg Val 
            980                 985                 990         


Asp Lys Lys Pro Asn Arg Lys Leu  Ile Asn Asp Thr Leu  Tyr Ser Thr 
        995                 1000                 1005             


Arg Lys  Asp Asp Lys Gly Asn  Thr Leu Ile Val Asn  Asn Leu Asn 
    1010                 1015                 1020             


Gly Leu  Tyr Asp Lys Asp Asn  Asp Lys Leu Lys Lys  Leu Ile Asn 
    1025                 1030                 1035             


Lys Ser  Pro Glu Lys Leu Leu  Met Tyr His His Asp  Pro Gln Thr 
    1040                 1045                 1050             


Tyr Gln  Lys Leu Lys Leu Ile  Met Glu Gln Tyr Gly  Asp Glu Lys 
    1055                 1060                 1065             


Asn Pro  Leu Tyr Lys Tyr Tyr  Glu Glu Thr Gly Asn  Tyr Leu Thr 
    1070                 1075                 1080             


Lys Tyr  Ser Lys Lys Asp Asn  Gly Pro Val Ile Lys  Lys Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Gly Asn Lys Leu Asn  Ala His Leu Asp Ile  Thr Asp Asp 
    1100                 1105                 1110             


Tyr Pro  Asn Ser Arg Asn Lys  Val Val Lys Leu Ser  Leu Lys Pro 
    1115                 1120                 1125             


Tyr Arg  Phe Asp Val Tyr Leu  Asp Asn Gly Val Tyr  Lys Phe Val 
    1130                 1135                 1140             


Thr Val  Lys Asn Leu Asp Val  Ile Lys Lys Glu Asn  Tyr Tyr Glu 
    1145                 1150                 1155             


Val Asn  Ser Lys Cys Tyr Glu  Glu Ala Lys Lys Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ser Asn  Gln Ala Glu Phe Ile  Ala Ser Phe Tyr Lys  Asn Asp Leu 
    1175                 1180                 1185             


Ile Lys  Ile Asn Gly Glu Leu  Tyr Arg Val Ile Gly  Val Asn Asn 
    1190                 1195                 1200             


Asp Leu  Leu Asn Arg Ile Glu  Val Asn Met Ile Asp  Ile Thr Tyr 
    1205                 1210                 1215             


Arg Glu  Tyr Leu Glu Asn Met  Asn Asp Lys Arg Pro  Pro His Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Ala Ser Lys  Thr Gln Ser Ile Lys  Lys Tyr Ser 
    1235                 1240                 1245             


Thr Asp  Ile Leu Gly Asn Leu  Tyr Glu Val Lys Ser  Lys Lys His 
    1250                 1255                 1260             


Pro Gln  Ile Ile Lys Lys Gly  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1265                 1270                 1275             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1280                 1285                 1290     


<210>  3252
<211>  1823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3252

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn 
                405                 410                 415     


Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile 
            420                 425                 430         


Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val 
        435                 440                 445             


Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met 
    450                 455                 460                 


Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe 
465                 470                 475                 480 


Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala 
                485                 490                 495     


Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro 
            500                 505                 510         


Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys 
        515                 520                 525             


Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met 
    530                 535                 540                 


Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys 
545                 550                 555                 560 


Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr 
                565                 570                 575     


Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala 
            580                 585                 590         


Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 
        595                 600                 605             


Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 
    610                 615                 620                 


Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr 
625                 630                 635                 640 


Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile 
                645                 650                 655     


Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His 
            660                 665                 670         


Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe 
        675                 680                 685             


Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr 
    690                 695                 700                 


Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala 
705                 710                 715                 720 


Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 
                725                 730                 735     


Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            740                 745                 750         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser 
        755                 760                 765             


Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
    770                 775                 780                 


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
785                 790                 795                 800 


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
                805                 810                 815     


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
            820                 825                 830         


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
        835                 840                 845             


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
    850                 855                 860                 


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
865                 870                 875                 880 


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
                885                 890                 895     


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
            900                 905                 910         


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
        915                 920                 925             


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
    930                 935                 940                 


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
945                 950                 955                 960 


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
                965                 970                 975     


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
            980                 985                 990         


Gly Glu Lys Lys Asn Gly Leu Phe  Gly Asn Leu Ile Ala  Leu Ser Leu 
        995                 1000                 1005             


Gly Leu  Thr Pro Asn Phe Lys  Ser Asn Phe Asp Leu  Ala Glu Asp 
    1010                 1015                 1020             


Ala Lys  Leu Gln Leu Ser Lys  Asp Thr Tyr Asp Asp  Asp Leu Asp 
    1025                 1030                 1035             


Asn Leu  Leu Ala Gln Ile Gly  Asp Gln Tyr Ala Asp  Leu Phe Leu 
    1040                 1045                 1050             


Ala Ala  Lys Asn Leu Ser Asp  Ala Ile Leu Leu Ser  Asp Ile Leu 
    1055                 1060                 1065             


Arg Val  Asn Thr Glu Ile Thr  Lys Ala Pro Leu Ser  Ala Ser Met 
    1070                 1075                 1080             


Ile Lys  Arg Tyr Asp Glu His  His Gln Asp Leu Thr  Leu Leu Lys 
    1085                 1090                 1095             


Ala Leu  Val Arg Gln Gln Leu  Pro Glu Lys Tyr Lys  Glu Ile Phe 
    1100                 1105                 1110             


Phe Asp  Gln Ser Lys Asn Gly  Tyr Ala Gly Tyr Ile  Asp Gly Gly 
    1115                 1120                 1125             


Ala Ser  Gln Glu Glu Phe Tyr  Lys Phe Ile Lys Pro  Ile Leu Glu 
    1130                 1135                 1140             


Lys Met  Asp Gly Thr Glu Glu  Leu Leu Val Lys Leu  Asn Arg Glu 
    1145                 1150                 1155             


Asp Leu  Leu Arg Lys Gln Arg  Thr Phe Asp Asn Gly  Ser Ile Pro 
    1160                 1165                 1170             


His Gln  Ile His Leu Gly Glu  Leu His Ala Ile Leu  Arg Arg Gln 
    1175                 1180                 1185             


Glu Asp  Phe Tyr Pro Phe Leu  Lys Asp Asn Arg Glu  Lys Ile Glu 
    1190                 1195                 1200             


Lys Ile  Leu Thr Phe Arg Ile  Pro Tyr Tyr Val Gly  Pro Leu Ala 
    1205                 1210                 1215             


Arg Gly  Asn Ser Arg Phe Ala  Trp Met Thr Arg Lys  Ser Glu Glu 
    1220                 1225                 1230             


Thr Ile  Thr Pro Trp Asn Phe  Glu Glu Val Val Asp  Lys Gly Ala 
    1235                 1240                 1245             


Ser Ala  Gln Ser Phe Ile Glu  Arg Met Thr Asn Phe  Asp Lys Asn 
    1250                 1255                 1260             


Leu Pro  Asn Glu Lys Val Leu  Pro Lys His Ser Leu  Leu Tyr Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Val Tyr Asn Glu  Leu Thr Lys Val Lys  Tyr Val Thr 
    1280                 1285                 1290             


Glu Gly  Met Arg Lys Pro Ala  Phe Leu Ser Gly Glu  Gln Lys Lys 
    1295                 1300                 1305             


Ala Ile  Val Asp Leu Leu Phe  Lys Thr Asn Arg Lys  Val Thr Val 
    1310                 1315                 1320             


Lys Gln  Leu Lys Glu Asp Tyr  Phe Lys Lys Ile Glu  Cys Phe Asp 
    1325                 1330                 1335             


Ser Val  Glu Ile Ser Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu 
    1340                 1345                 1350             


Gly Thr  Tyr His Asp Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe 
    1355                 1360                 1365             


Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu 
    1370                 1375                 1380             


Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu 
    1385                 1390                 1395             


Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu 
    1400                 1405                 1410             


Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu 
    1415                 1420                 1425             


Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp 
    1430                 1435                 1440             


Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu 
    1445                 1450                 1455             


Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala 
    1460                 1465                 1470             


Gln Val  Ser Gly Gln Gly Asp  Ser Leu His Glu His  Ile Ala Asn 
    1475                 1480                 1485             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1490                 1495                 1500             


Lys Val  Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
    1505                 1510                 1515             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1520                 1525                 1530             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1535                 1540                 1545             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1550                 1555                 1560             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1565                 1570                 1575             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1580                 1585                 1590             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1595                 1600                 1605             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1610                 1615                 1620             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1625                 1630                 1635             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1640                 1645                 1650             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1655                 1660                 1665             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1670                 1675                 1680             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1685                 1690                 1695             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1700                 1705                 1710             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1715                 1720                 1725             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1730                 1735                 1740             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1745                 1750                 1755             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1760                 1765                 1770             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1775                 1780                 1785             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Ser 
    1790                 1795                 1800             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1805                 1810                 1815             


Lys Lys  Arg Lys Val 
    1820             


<210>  3253
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3253

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Gln Tyr  Arg Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  3254
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3254

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Val Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Arg Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Gln Tyr Arg Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  3255
<211>  1534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3255

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Ser Gly  Gly Ser Lys 
    1505                 1510                 1515             


Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys 
    1520                 1525                 1530             


Val 
    


<210>  3256
<211>  1336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3256

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1310                 1315                 1320             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1325                 1330                 1335     


<210>  3257
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (51)..(65)
<223>  n is a, c, g, or t

<400>  3257
tttttgtttt gtctgtgttc cgttgtccgt gctgtaacga aaggtgcagt nnnnnnnnnn       60

nnnnngatgg gtgcgacgcg tcat                                              84


<210>  3258
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3258
gttgataacg gactagcctt atttaaactt gctatgctgt ttccagcata gctcttaaac       60


<210>  3259
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3259
gtttaagagc tatgctggaa acagc                                             25


<210>  3260
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3260
actgcacctt tcgttacagc acggacaacg gaacacagac aaaacaaaaa agcaccgact       60

c                                                                       61


<210>  3261
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3261
taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg       60


<210>  3262
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3262
ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgctcgaagc ggccgtacct       60

ctagacactc tttccctaca cgacgctctt                                        90


<210>  3263
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3263
aatgatacgg cgaccaccga gatctacaca cactctttcc ctacacgac                   49


<210>  3264
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3264
gtgactggag ttcagacgtg tgctcttccg atctgtggaa aggacgaaac accg             54


<210>  3265
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3265
aatgatacgg cgaccaccga gatctacac                                         29


<210>  3266
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3266
caagcagaag acggcatacg agatgtgact ggagttcaga cgtgtgctct tc               52


<210>  3267
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3267
gaacacaaag catagactgc                                                   20


<210>  3268
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3268
ggcactgcgg ctggaggtgg                                                   20


<210>  3269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3269
ggcgtactcc atgacaaagc                                                   20


<210>  3270
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3270
gagtccgagc agaagaagaa                                                   20


<210>  3271
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3271
ccagccccat ctgtcaaact                                                   20


<210>  3272
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3272
tgaatggatt ccttggaaac aatga                                             25


<210>  3273
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3273
atgtgggctg cctagaaagg                                                   20


<210>  3274
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3274
cccagccaaa cttgtcaacc                                                   20


<210>  3275
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3275
gaacccaggt agccagagac                                                   20


<210>  3276
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3276
tcctttcaac ccgaacggag                                                   20


<210>  3277
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3277
gtctggtgcc atggagagta g                                                 21


<210>  3278
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3278
ggtatcaggc gacgtggtat                                                   20


<210>  3279
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3279
cagctcagcc tgagtgttga                                                   20


<210>  3280
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3280
ctcgtgggtt tgtggttgc                                                    19


<210>  3281
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3281
tgctggacct gtgcccccgc                                                   20


<210>  3282
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3282
attgtcgagg aatgccgaaa tgctggacct gtgcccccgc gtggacctac                  50


<210>  3283
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3283
attgtcgagg aatgccgaaa tgctggatct gtgcccccgc gtggacctac                  50


<210>  3284
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3284
attgtcgagg aatgccgaaa tgctggattt gtgcccccgc gtggacctac                  50


<210>  3285
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3285
attgtcgagg aatgccgaaa tgctggactt gtgcccccgc gtggacctac                  50


<210>  3286
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3286
attgtcgagg aatgccgaaa tgttggattt gtgcccccgc gtggacctac                  50


<210>  3287
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3287
attgtcgagg aatgccgaaa tgctggaact gtgcccccgc gtggacctac                  50


<210>  3288
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3288
attgtcgagg aatgccgaaa tgttggacct gtgcccccgc gtggacctac                  50


<210>  3289
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3289
attgtcgagg aatgccgaaa tgttggatct gtgcccccgc gtggacctac                  50


<210>  3290
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3290
attgtcgagg aatgccgaaa tgctggagct gtgcccccgc gtggacctac                  50


<210>  3291
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3291
attgtcgagg aatgccgaaa tgctggacat gtgcccccgc gtggacctac                  50


<210>  3292
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3292
attgtcgagg aatgccgaaa tgctggatat gtgcccccgc gtggacctac                  50


<210>  3293
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3293

Asn Asp Leu Phe Ala Ser Ile Ser Ser Arg His Gly Arg Thr Ser Arg 
1               5                   10                  15      


<210>  3294
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3294

Asn Asp Leu Phe Ala Ser Ile Ser Ser Lys His Gly Arg Thr Ser Arg 
1               5                   10                  15      


<210>  3295
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3295

Asn Asp Leu Phe Ala Ser Ile Asn Ser Arg His Gly Arg Thr Ser Arg 
1               5                   10                  15      


<210>  3296
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3296

Asn Asp Leu Phe Ala Ser Ile Ser Ser Ser His Gly Arg Thr Ser Arg 
1               5                   10                  15      


<210>  3297
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3297
tgaagcagcg gt                                                           12


<210>  3298
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3298
aggagcagcc ac                                                           12


<210>  3299
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3299
cggagcagcc ca                                                           12


<210>  3300
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3300
agaagcagag gc                                                           12


<210>  3301
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3301
acagactttt ct                                                           12


<210>  3302
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3302
aagtgcgtcc tt                                                           12


<210>  3303
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3303
tggtgcttct gc                                                           12


<210>  3304
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3304
ctgtgcgtcc cc                                                           12


<210>  3305
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3305
ctttgctgtc gt                                                           12


<210>  3306
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  n is a, c, g, or t

<400>  3306
ncncnnnnn                                                                9


<210>  3307
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3307
gacgcaggtg                                                              10


<210>  3308
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3308
tgcacgtttg                                                              10


<210>  3309
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3309
ggcacgggtg                                                              10


<210>  3310
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3310
gacacaggtg                                                              10


<210>  3311
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3311
gacacggtgg                                                              10


<210>  3312
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3312
ggcacagtgg                                                              10


<210>  3313
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3313
tgcacggagt                                                              10


<210>  3314
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3314
gacacgatta                                                              10


<210>  3315
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3315
agcacagagg                                                              10


<210>  3316
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3316
gacacagggg                                                              10


<210>  3317
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3317
aacactgagt                                                              10


<210>  3318
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3318
agctcgaaga                                                              10


<210>  3319
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3319
tgcacaggga                                                              10


<210>  3320
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3320
tgcactgaag                                                              10


<210>  3321
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3321
gacacggtag                                                              10


<210>  3322
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3322
agcactgaga                                                              10


<210>  3323
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3323
cacacagatg                                                              10


<210>  3324
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3324
gacactgatg                                                              10


<210>  3325
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3325
cacgcggggg                                                              10


<210>  3326
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3326
gacacgaagg                                                              10


<210>  3327
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3327
tacgcgagtg                                                              10


<210>  3328
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3328
ttcactgagg                                                              10


<210>  3329
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3329
ttcactggag                                                              10


<210>  3330
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3330
ttcactgtgg                                                              10


<210>  3331
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3331
ctcacggttg                                                              10


<210>  3332
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3332
atcactgggg                                                              10


<210>  3333
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3333
ctcactgatg                                                              10


<210>  3334
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3334
gtcactgagg                                                              10


<210>  3335
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3335
atcacggaag                                                              10


<210>  3336
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3336
ttcacgtgtg                                                              10


<210>  3337
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  n is a, c, g, or t

<400>  3337
nnnnanann                                                                9


<210>  3338
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3338
ggtttacacc                                                              10


<210>  3339
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3339
accttacagg                                                              10


<210>  3340
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3340
ggcctagact                                                              10


<210>  3341
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3341
cctttagagc                                                              10


<210>  3342
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3342
gctgcacagc                                                              10


<210>  3343
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3343
ggtccagagt                                                              10


<210>  3344
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3344
atttcagatg                                                              10


<210>  3345
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3345
gtctcagatg                                                              10


<210>  3346
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3346
tcgtcagagc                                                              10


<210>  3347
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3347
tgcctacagg                                                              10


<210>  3348
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3348
ctggcacatg                                                              10


<210>  3349
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3349
ggttgacatt                                                              10


<210>  3350
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3350
tccccacagc                                                              10


<210>  3351
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3351
ggcctacatg                                                              10


<210>  3352
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3352
gcggcacagt                                                              10


<210>  3353
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3353
cttctagagg                                                              10


<210>  3354
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3354
ggtggacagc                                                              10


<210>  3355
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3355
ccttcacagc                                                              10


<210>  3356
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3356
tgctcacacc                                                              10


<210>  3357
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3357
gcgctagatg                                                              10


<210>  3358
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3358
gggctagagc                                                              10


<210>  3359
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3359
ctgctatagc                                                              10


<210>  3360
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3360
ccgccagacg                                                              10


<210>  3361
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3361
agcgcacacg                                                              10


<210>  3362
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3362
atgtgacacc                                                              10


<210>  3363
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3363
ctcggagatg                                                              10


<210>  3364
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3364
gtggcacatc                                                              10


<210>  3365
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3365
actcgatatt                                                              10


<210>  3366
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3366
cccctatacc                                                              10


<210>  3367
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3367
ttttcatact                                                              10


<210>  3368
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3368
ggccagctcg aagacccg                                                     18


<210>  3369
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3369
ctttgacaca ggggattt                                                     18


<210>  3370
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3370
aggtgacaca ggtgcgac                                                     18


<210>  3371
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3371
cgttggcacg ggtgacgg                                                     18


<210>  3372
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3372
ggcggtcact gaggttct                                                     18


<210>  3373
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3373
ccagttcact gaggctag                                                     18


<210>  3374
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3374
ctggctcact gatgggca                                                     18


<210>  3375
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3375
gcagatcact ggggtgga                                                     18


<210>  3376
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3376
tccagacact gatgaatg                                                     18


<210>  3377
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3377
acccaacact gagtggta                                                     18


<210>  3378
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3378
gctgtgcaca gggaattc                                                     18


<210>  3379
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3379
caggtgcacg tttgccta                                                     18


<210>  3380
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3380
cccagacacg aagggaga                                                     18


<210>  3381
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3381
cgcaagcaca gaggccgg                                                     18


<210>  3382
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3382
ggagctcacg gttggttg                                                     18


<210>  3383
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3383
caatgacacg gtagatga                                                     18


<210>  3384
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3384
tgaggacacg gtggtgga                                                     18


<210>  3385
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3385
agtggacgca ggtgttga                                                     18


<210>  3386
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  n is a, c, g, or t

<400>  3386
nncnncnnn                                                                9


<210>  3387
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3387
acgctgactg cggtccct                                                     18


<210>  3388
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3388
aagcggactt cgtggcgg                                                     18


<210>  3389
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3389
ctcaggactt cgagttca                                                     18


<210>  3390
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3390
cccagggcgt cgaaggcg                                                     18


<210>  3391
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3391
tgctgttcaa ctgatggg                                                     18


<210>  3392
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3392
ctgctatcaa cgaactgt                                                     18


<210>  3393
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3393
agggcggcaa cggtgtag                                                     18


<210>  3394
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3394
agttctgcag cgtgccac                                                     18


<210>  3395
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3395
agcatgactg cggggcgc                                                     18


<210>  3396
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3396
catctgacgg caagcaac                                                     18


<210>  3397
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  3397

Arg Arg Glu Thr Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala 
1               5                   10                  15      


Thr Ser Phe Ser Leu Asp Phe Gly Tyr Leu 
            20                  25      


<210>  3398
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3398

Arg His Glu Thr Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala 
1               5                   10                  15      


Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
            20                  25  


<210>  3399
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3399

Arg His Glu Thr Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala 
1               5                   10                  15      


Thr Ser Phe Ser Leu Asp Phe Gly His Leu 
            20                  25      


<210>  3400
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  3400

Arg His Glu Thr Tyr Leu Cys Tyr Val Val Lys Gln Arg Asn Ser Ala 
1               5                   10                  15      


Thr Ser Cys Ser Leu Asp Phe Gly Tyr Leu 
            20                  25      


<210>  3401
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3401

Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly 
1               5                   10                  15      


Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His Asn 
            20                  25                  30  


<210>  3402
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3402

Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly 
1               5                   10                  15      


Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His Gly 
            20                  25                  30  


<210>  3403
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3403

Arg His Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly 
1               5                   10                  15      


Thr Trp Val Pro Met Asp Gln His Trp Gly Phe Leu Cys Asn 
            20                  25                  30  


<210>  3404
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3404

Arg His Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly 
1               5                   10                  15      


Thr Trp Val Leu Met Asp Arg His Met Gly Phe Leu Cys Asn 
            20                  25                  30  


<210>  3405
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3405

Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu His Asn Asp 
1               5                   10                  15      


Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
            20                  25                  30  


<210>  3406
<211>  25
<212>  PRT
<213>  Rattus norvegicus

<400>  3406

Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
1               5                   10                  15      


Ser Ile Trp Arg His Thr Ser Gln Asn 
            20                  25  


<210>  3407
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3407

Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
1               5                   10                  15      


Ser Val Trp Arg His Thr Ser Gln Asn 
            20                  25  


<210>  3408
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3408

Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser His 
1               5                   10                  15      


Asn Ile Trp Arg Tyr Ser Gly Lys Asn 
            20                  25  


<210>  3409
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3409

Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Gln Trp Gly Thr Ser Arg 
1               5                   10                  15      


Lys Ile Trp Arg Asn Ser Ser Lys Asn 
            20                  25  


<210>  3410
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3410

Arg Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala 
1               5                   10                  15      


Cys Phe Trp Gly Tyr Ala Val Asn 
            20                  


<210>  3411
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3411
ggtgatatct tggatagcgg                                                   20


<210>  3412
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3412
ggtgatatct tggaagccag                                                   20


<210>  3413
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3413
ggttgttctt tgaaaaccgt                                                   20


<210>  3414
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3414
ggtgaggtcc tagaagtgca                                                   20


<210>  3415
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3415
ggggatgtcc ttgaagccgc                                                   20


<210>  3416
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3416
ggagatgtcc tggaatcgct                                                   20


<210>  3417
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3417
gccttaacgg gcactctgtc                                                   20


<210>  3418
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3418
ggagatatct tggaaacatc                                                   20


<210>  3419
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3419
ggtgatgtcc ttgagccgag                                                   20


<210>  3420
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3420
gagtcctaga gtgttatctt taggcacga                                         29


<210>  3421
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3421
taggcacgat acaggtacat                                                   20


<210>  3422
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3422
gagtcctaga gtgttatctt taggcacgat acaggtacat gaatccgctc                  50


<210>  3423
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3423
gagtcctaga gtgttatctt taggcatgat acaggtacat gaatccgctc                  50


<210>  3424
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3424
gagtcctaga gtgttatttt taggcatgat acaggtacat gaatccgctc                  50


<210>  3425
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3425
gagtcctaga gtgttatctt taggtatgat acaggtacat gaatccgctc                  50


<210>  3426
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3426
gagtcctaga gtgttatttt taggtatgat acaggtacat gaatccgctc                  50


<210>  3427
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3427
gagtcctaga gtgttatttt taggcacgat acaggtacat gaatccgctc                  50


<210>  3428
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3428
gagtcctaga gtgttatctt taggtacgat acaggtacat gaatccgctc                  50


<210>  3429
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3429
gagtcctaga gtgttatttt taggtacgat acaggtacat gaatccgctc                  50


<210>  3430
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3430
gagtcctaga gtgttatctt taggcaggat acaggtacat gaatccgctc                  50


<210>  3431
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3431
gagtcctaga gtgttatgtt taggcacgat acaggtacat gaatccgctc                  50


<210>  3432
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3432
gagtcctaga gtgttatgtt taggcatgat acaggtacat gaatccgctc                  50


<210>  3433
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3433
aggcacgata caggtacatg                                                   20


<210>  3434
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3434
ggcacgatac aggtacatga                                                   20


<210>  3435
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3435
cacgatacag gtacatgaat                                                   20


<210>  3436
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3436
acgatacagg tacatgaatc                                                   20


<210>  3437
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3437
gagtcctaga gtgttaatga atccgctc                                          28


<210>  3438
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3438
tcctagagtg ttatctttag gcacgataca ggtacatgaa tccgctcatc                  50


<210>  3439
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3439
tcctagagtg ttatctttag gcatgataca ggtacatgaa tccgctcatc                  50


<210>  3440
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3440
tcctagagtg ttatctttag gcacgatata ggtacatgaa tccgctcatc                  50


<210>  3441
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3441
tcctagagtg ttatctttag gcatgatata ggtacatgaa tccgctcatc                  50


<210>  3442
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3442
tcctagagtg ttatttttag gcacgataca ggtacatgaa tccgctcatc                  50


<210>  3443
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3443
tcctagagtg ttatctttag gcaggataca ggtacatgaa tccgctcatc                  50


<210>  3444
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3444
tcctagagtg ttatctttag gcaagataca ggtacatgaa tccgctcatc                  50


<210>  3445
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3445
tcctagagtg ttatctttag gcacgataga ggtacatgaa tccgctcatc                  50


<210>  3446
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3446
tcctagagtg ttatctttag gcacgataca ggtatatgaa tccgctcatc                  50


<210>  3447
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3447
tcctagagtg ttatatttag gcacgataca ggtacatgaa tccgctcatc                  50


<210>  3448
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3448
tcctagagtg ttatctttag gcatgataca ggtatatgaa tccgctcatc                  50


<210>  3449
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3449
gagtccagag tgttatcttt aggcacga                                          28


<210>  3450
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3450
tcctagagtg ttatctttag gcacgatata ggtatatgaa tccgctcatc                  50


<210>  3451
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3451
tcctagagtg ttatctttag gcatgatata ggtatatgaa tccgctcatc                  50


<210>  3452
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3452
tcctagagtg ttatctttag gcacgataaa ggtacatgaa tccgctcatc                  50


<210>  3453
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3453
gctcagggcg gcaacggtgt agcggcgggg g                                      31


<210>  3454
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3454
gctcagggcg gcaatggtgt agcggcgggg g                                      31


<210>  3455
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3455
gttacttacg aacgtacgag cgtta                                             25


<210>  3456
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3456
atattgagcg tacca                                                        15


<210>  3457
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3457
atattgggcg tacca                                                        15


<210>  3458
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3458
atgttgagcg tacca                                                        15


<210>  3459
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3459
atattgagcg tgcca                                                        15


<210>  3460
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3460
atattgggcg tgcca                                                        15


<210>  3461
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3461
atgttgggcg tacca                                                        15


<210>  3462
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3462
atgttgggcg tgcca                                                        15


<210>  3463
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3463
atgttgagcg tgcca                                                        15


<210>  3464
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3464
gtattgagcg tacca                                                        15


<210>  3465
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3465
atattgagcg taccg                                                        15


<210>  3466
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3466
ttctaggcta gcgc                                                         14


<210>  3467
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3467
ttttaggcta gcgc                                                         14


<210>  3468
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3468
ttgtaggcta gcgc                                                         14


<210>  3469
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3469
ttttaggtta gcgc                                                         14


<210>  3470
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3470
ttctagggta gcgc                                                         14


<210>  3471
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3471
ttttaggtta gtgc                                                         14


<210>  3472
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3472
ttctaggtta gcgc                                                         14


<210>  3473
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3473
ttataggcta gcgc                                                         14


<210>  3474
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3474
ttttagggta gcgc                                                         14


<210>  3475
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3475
ttctaggata gcgc                                                         14


<210>  3476
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3476

Leu Glu Cys Tyr Leu Ala Arg Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  15  


<210>  3477
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3477

Leu Glu Cys Tyr Leu Ala Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  


<210>  3478
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3478

Leu Glu Cys Tyr Leu Ala Arg Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  


<210>  3479
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3479

Leu Glu Cys Tyr Phe Ala Arg Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  15  


<210>  3480
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3480
agtcctagag tgttatcttt aggcacgata caggtacatg aatccgctca                  50


<210>  3481
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3481
agtcctagag tgttatcttt aggcatgata caggtacatg aatccgctca                  50


<210>  3482
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3482
agtcctagag tgttatcttt aggtatgata caggtacatg aatccgctca                  50


<210>  3483
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3483
agtcctagag tgttatcttt aggcaggata caggtacatg aatccgctca                  50


<210>  3484
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3484
agtcctagag tgttatcttt aggtacgata caggtacatg aatccgctca                  50


<210>  3485
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3485
agtcctagag tgttatcttt aggtatgata taggtacatg aatccgctca                  50


<210>  3486
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3486
agtcctagag tgttattttt aggcatgata caggtacatg aatccgctca                  50


<210>  3487
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3487
agtcctagag tgttatcttt aggcaagata caggtacatg aatccgctca                  50


<210>  3488
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3488
agtcctagag tgttattttt aggtatgata caggtacatg aatccgctca                  50


<210>  3489
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3489
agtcctagag tgttatcttt aggcatgata taggtacatg aatccgctca                  50


<210>  3490
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3490
agtcctagag tgttattttt aggcacgata caggtacatg aatccgctca                  50


<210>  3491
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3491

Ser Pro Arg Val Leu Ser Leu Gly Thr Ile Gln Val His Glu Ser Ala 
1               5                   10                  15      


<210>  3492
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3492

Ser Pro Arg Val Leu Ser Leu Gly Met Ile Gln Val His Glu Ser Ala 
1               5                   10                  15      


<210>  3493
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3493

Ser Pro Arg Val Leu Ser Leu Gly Arg Ile Gln Val His Glu Ser Ser 
1               5                   10                  15      


Ala 
    


<210>  3494
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3494

Ser Pro Arg Val Leu Ser Leu Gly Met Ile Val His Glu Ser Ala 
1               5                   10                  15  


<210>  3495
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3495

Ser Pro Arg Val Leu Phe Leu Gly Met Ile Gln Val His Glu Ser Ala 
1               5                   10                  15      


<210>  3496
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3496

Ser Pro Arg Val Leu Ser Leu Gly Lys Ile Gln Val His Glu Ser Ala 
1               5                   10                  15      


<210>  3497
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3497
tcctagagtg t                                                            11


<210>  3498
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3498

Leu Glu Cys Tyr Leu Ala Gly Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  15  


<210>  3499
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3499

Leu Glu Cys Tyr Leu Ala Arg Tyr Arg Met Asn Pro Leu Ile 
1               5                   10                  


<210>  3500
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3500

Leu Glu Cys Tyr Leu Val Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  


<210>  3501
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3501

Leu Glu Cys Tyr Leu Ala Arg Tyr Met Asn Pro Leu Ile 
1               5                   10              


<210>  3502
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3502

Leu Glu Cys Tyr Val Ala Arg Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  15  


<210>  3503
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3503

Leu Glu Cys Tyr Ile Ala Arg Tyr Arg Tyr Met Asn Pro Leu Ile 
1               5                   10                  15  


<210>  3504
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3504
tcctagagtg ttatcttt                                                     18


