                         SEQUENCE LISTING

<110>  Navigo Proteins GmbH
 
<120>  AFFINITY LIGAND FOR THE SOLUBLE PART OF FIBROBLAST GROWTH FACTOR 
       RECEPTOR 3 (sFGFR3)

<130>  NP46 WO

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 1 (204815 monomer)

<400>  1

Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile 
1               5                   10                  15      


Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys 
    50                  55              


<210>  2
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 2 (204783 monomer)

<400>  2

Ile Ala Ala Lys Phe Asp Gln His Gln Ser Thr Ala Asp Glu Ile Ile 
1               5                   10                  15      


Leu Lys Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Thr Ser Val Ser Arg Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Leu Trp Leu Asn Ala Ser Gln Ala Pro Lys 
    50                  55              


<210>  3
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 3 (206146 monomer)

<400>  3

Ile Ala Ala Lys Phe Asp Tyr Val Gln Ser Met Ala Asp Ala Gln Ile 
1               5                   10                  15      


Leu Gln Leu Ile Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Met Val Val Leu Tyr Arg Ala 
        35                  40                  45              


Asp Trp Leu Asn Glu His Gln Ala Pro Lys 
    50                  55              


<210>  4
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 4 (206142 monomer)

<400>  4

Ile Ala Ala Lys Phe Asp Tyr Ile Gln His Met Ala Asp Asp Tyr Ile 
1               5                   10                  15      


Leu Gln Leu Arg Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Met Val Val Leu Tyr Arg Ala 
        35                  40                  45              


Asp Trp Leu Asn Glu His Gln Ala Pro Lys 
    50                  55              


<210>  5
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 5 (206141 monomer)

<400>  5

Ile Ala Ala Lys Phe Asp Tyr Ile Gln Glu Met Ala Asp Lys His Ile 
1               5                   10                  15      


Leu Met Leu His Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Met Leu Val Leu Tyr Lys Ala 
        35                  40                  45              


His Trp Leu Asn Gln Ser Gln Ala Pro Lys 
    50                  55              


<210>  6
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 6 (206137 monomer)

<400>  6

Ile Ala Ala Lys Phe Asp Asp Ile Gln Met Met Ala Asp Ala Gln Ile 
1               5                   10                  15      


Leu Ile Leu Tyr Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Val Val Leu Tyr Lys Ala 
        35                  40                  45              


Asp Trp Leu Asn Arg His Gln Ala Pro Lys 
    50                  55              


<210>  7
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 7 (206136 monomer)

<400>  7

Ile Ala Ala Lys Phe Asp Gln Ile Gln Ala Met Ala Asp Gln Tyr Ile 
1               5                   10                  15      


Leu His Leu Met Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Met Ile Val Leu Tyr Lys Ala 
        35                  40                  45              


Asp Trp Leu Asn Asp Lys Gln Ala Pro Lys 
    50                  55              


<210>  8
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 8 (206121 monomer)

<400>  8

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Tyr His Arg Ile Gln His Arg Tyr 
            20                  25                  30          


Trp Leu Val Trp Asp Pro Ser Val Ser Gln Phe Thr Leu Arg Asp Ala 
        35                  40                  45              


Gln Ala Leu Asn Asp Trp Gln Ala Pro Lys 
    50                  55              


<210>  9
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein 9 (206113 monomer)

<400>  9

Asn Ala Ala Ser Glu Asp Trp Ala Gln Phe Ser Ala Met Tyr Glu Ile 
1               5                   10                  15      


Asp His Leu Pro Asn Leu Thr Met Arg Gln Ala Ile Trp Phe Ile His 
            20                  25                  30          


Ser Leu Tyr His Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  10
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein  (consensus sequence for SEQs 1 - 7)


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa may be selected from any amino acid, preferably H, Q, Y, or D

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa may be selected from any amino acid, preferably H, K, V, or I

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa may be selected from any amino acid, preferably S, H, E, M, 
       or A

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa may be selected from any amino acid, preferably T or M

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa may be selected from any amino acid, preferably T or E

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa may be selected from any amino acid, preferably K or E

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa may be selected from any amino acid, preferably P, I, R, H, 
       Y, or M

<220>
<221>  Xaa
<222>  (38)..(38)
<223>  Xaa may be selected from any amino acid, preferably P or T

<220>
<221>  Xaa
<222>  (42)..(42)
<223>  Xaa may be selected from any amino acid, preferably K, R, M, or L

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  Xaa may be selected from any amino acid, preferably E, V, L, or I

<220>
<221>  Xaa
<222>  (47)..(47)
<223>  Xaa may be selected from any amino acid, preferably E, R, or K

<220>
<221>  Xaa
<222>  (49)..(49)
<223>  Xaa may be selected from any amino acid, preferably I, L, D, or H

<220>
<221>  Xaa
<222>  (53)..(53)
<223>  Xaa may be selected from any amino acid, preferably W, A, E, Q, 
       R, or D

<400>  10

Ile Ala Ala Lys Phe Asp Xaa Xaa Gln Xaa Xaa Ala Asp Xaa Xaa Ile 
1               5                   10                  15      


Leu Xaa Leu Xaa Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Xaa Ser Val Ser Xaa Xaa Val Leu Tyr Xaa Ala 
        35                  40                  45              


Xaa Trp Leu Asn Xaa Ser Gln Ala Pro Lys 
    50                  55              


<210>  11
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein  (tetramer of SEQ ID NO: 1; CID206078)

<400>  11

Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile 
1               5                   10                  15      


Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala 
        115                 120                 125             


Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val 
145                 150                 155                 160 


Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Cys 
                165                 170                 175 


<210>  12
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID204815 (SEQ ID NO: 1 with PAdelFc)

<400>  12

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  13
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID204783 (SEQ ID NO: 2 with PAdelFc)

<400>  13

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Gln His Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Thr 
                85                  90                  95      


Ser Val Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp Leu Asn Ala Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  14
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID204815 (SEQ ID NO: 1 with PAdelFc; Streptag, 
       Cys)

<400>  14

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  15
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID204783 (SEQ ID NO: 2 with PAdelFc; Streptag, 
       Cys)

<400>  15

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Gln His Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Thr 
                85                  90                  95      


Ser Val Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp Leu Asn Ala Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  16
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206113 (SEQ ID NO: 9 with PAdelFc)

<400>  16

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Asn Ala Ala Ser Glu Asp 
    50                  55                  60                  


Trp Ala Gln Phe Ser Ala Met Tyr Glu Ile Asp His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Met Arg Gln Ala Ile Trp Phe Ile His Ser Leu Tyr His Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  17
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206121 (SEQ ID NO: 8 with PAdelFc)

<400>  17

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Tyr His Arg Ile Gln His Arg Tyr Trp Leu Val Trp Asp Pro 
                85                  90                  95      


Ser Val Ser Gln Phe Thr Leu Arg Asp Ala Gln Ala Leu Asn Asp Trp 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  18
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206136 (SEQ ID NO: 7 with PAdelFc)

<400>  18

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Gln Ile Gln Ala Met Ala Asp Gln Tyr Ile Leu His Leu Met Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Ile Val Leu Tyr Lys Ala Asp Trp Leu Asn Asp Lys 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  19
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206137 (SEQ ID NO: 6 with PAdelFc)

<400>  19

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Asp Ile Gln Met Met Ala Asp Ala Gln Ile Leu Ile Leu Tyr Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Val Val Leu Tyr Lys Ala Asp Trp Leu Asn Arg His 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  20
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206141 (SEQ ID NO: 5 with PAdelFc)

<400>  20

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Tyr Ile Gln Glu Met Ala Asp Lys His Ile Leu Met Leu His Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Leu Val Leu Tyr Lys Ala His Trp Leu Asn Gln Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  21
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206142 (SEQ ID NO: 4 with PAdelFc)

<400>  21

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Tyr Ile Gln His Met Ala Asp Asp Tyr Ile Leu Gln Leu Arg Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Val Val Leu Tyr Arg Ala Asp Trp Leu Asn Glu His 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  22
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206146 (SEQ ID NO: 3 with PAdelFc)

<400>  22

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Tyr Val Gln Ser Met Ala Asp Ala Gln Ile Leu Gln Leu Ile Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Val Val Leu Tyr Arg Ala Asp Trp Leu Asn Glu His 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
                165                 170                 


<210>  23
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206113 (SEQ ID NO: 9 with PAdelFc; Streptag, 
       Cys)

<400>  23

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Asn Ala Ala Ser Glu Asp 
    50                  55                  60                  


Trp Ala Gln Phe Ser Ala Met Tyr Glu Ile Asp His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Met Arg Gln Ala Ile Trp Phe Ile His Ser Leu Tyr His Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  24
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206121 (SEQ ID NO: 8 with PAdelFc; Streptag, 
       Cys)

<400>  24

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Tyr His Arg Ile Gln His Arg Tyr Trp Leu Val Trp Asp Pro 
                85                  90                  95      


Ser Val Ser Gln Phe Thr Leu Arg Asp Ala Gln Ala Leu Asn Asp Trp 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  25
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206136 (SEQ ID NO: 7 with PAdelFc; Streptag, 
       Cys)

<400>  25

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Gln Ile Gln Ala Met Ala Asp Gln Tyr Ile Leu His Leu Met Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Ile Val Leu Tyr Lys Ala Asp Trp Leu Asn Asp Lys 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  26
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206137 (SEQ ID NO: 6 with PAdelFc; Streptag, 
       Cys)

<400>  26

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Asp Ile Gln Met Met Ala Asp Ala Gln Ile Leu Ile Leu Tyr Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Val Val Leu Tyr Lys Ala Asp Trp Leu Asn Arg His 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  27
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206141 (SEQ ID NO: 5 with PAdelFc; Streptag, 
       Cys)

<400>  27

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Tyr Ile Gln Glu Met Ala Asp Lys His Ile Leu Met Leu His Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Leu Val Leu Tyr Lys Ala His Trp Leu Asn Gln Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  28
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206142 (SEQ ID NO: 4 with PAdelFc; Streptag, 
       Cys)

<400>  28

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Tyr Ile Gln His Met Ala Asp Asp Tyr Ile Leu Gln Leu Arg Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Val Val Leu Tyr Arg Ala Asp Trp Leu Asn Glu His 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  29
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein CID206146 (SEQ ID NO: 3 with PAdelFc; Streptag, 
       Cys)

<400>  29

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Tyr Val Gln Ser Met Ala Asp Ala Gln Ile Leu Gln Leu Ile Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Met Val Val Leu Tyr Arg Ala Asp Trp Leu Asn Glu His 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala 
        115                 120                 125             


Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Cys Ser 
                165                 170                 175     


Ala Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  30
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAdelFc

<400>  30

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  31
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR3 Genbank Accession number NP 000133

<400>  31

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  32
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain (ECD) of Genbank Accession Number NP000133 
       (amino acids 23-375)

<400>  32

Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val Pro 
1               5                   10                  15      


Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly Asp 
            20                  25                  30          


Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly Pro 
        35                  40                  45              


Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg Val 
    50                  55                  60                  


Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu Asp 
65                  70                  75                  80  


Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu Cys 
                85                  90                  95      


His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp Glu 
            100                 105                 110         


Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala Pro 
        115                 120                 125             


Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro 
    130                 135                 140                 


Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr 
145                 150                 155                 160 


Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu His 
                165                 170                 175     


Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met 
            180                 185                 190         


Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu 
        195                 200                 205             


Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu 
    210                 215                 220                 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln 
225                 230                 235                 240 


Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser 
                245                 250                 255     


Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly 
            260                 265                 270         


Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr 
        275                 280                 285             


Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His 
    290                 295                 300                 


Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
305                 310                 315                 320 


Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala 
                325                 330                 335     


Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly 
            340                 345                 350         


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  streptag

<400>  33

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  34
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C27

<400>  34

Asn Ala Ala Lys Phe Asp Glu Ala Gln Gln Ser Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  35
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence 206078 (tetramer of SEQ ID NO: 1)

<400>  35
atgatcgcag ccaaattcga tcataaacag agcaccgcag ataccattat tctggaactg       60

ccgaatctga ccgaagaaca gcgtaatgca tttcgtcaga gcctgagtga tgatccgagc      120

gttagcaaag aagttctgta cgaagccatt tggctgaatt ggagccaggc accgaaaatt      180

gcagcaaaat ttgaccacaa acagtcaaca gccgatacaa tcattttaga actgcctaac      240

ttaacagagg aacagcgcaa cgcctttcgc cagtcactgt cagatgatcc gtcagtttca      300

aaagaggtgc tgtacgaggc aatctggtta aattggtcac aagcccctaa aatcgctgcg      360

aagtttgatc ataagcagtc tacagcggat acgataatcc tggaattacc gaatttaacg      420

gaagaacaac gcaatgcgtt ccgccagagt ctgagcgacg atccttcagt gagtaaagaa      480

gtgttatacg aggcgatatg gctgaactgg tcacaggctc caaaaatagc cgcaaagttc      540

gatcacaagc aatcaaccgc tgacacaatc atcctggaac ttccaaacct taccgaggaa      600

caaagaaatg ccttccgtca aagcctgtcc gacgatccga gtgtgtccaa agaggtttta      660

tacgaagcta tatggttaaa ttggagtcaa gctccgaaat gctaatga                   708


<210>  36
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAdelFc

<400>  36

Ile Ala Ala Gln His Asp Lys Asp Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Ile Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  37
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAdelFc

<400>  37

Ile Ala Ala Gln His Asp Lys Asp Gln Gln Ala Ala Asp Lys Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Ala Glu Ile Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  38
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence coding for SEQ ID NO: 1

<400>  38
atcgcagcca aattcgatca taaacagagc accgcagata ccattattct ggaactgccg       60

aatctgaccg aagaacagcg taatgcattt cgtcagagcc tgagtgatga tccgagcgtt      120

agcaaagaag ttctgtacga agccatttgg ctgaattgga gccaggcacc gaaa            174


<210>  39
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of sFGFR3 binding protein and non-Ig binding 
       protein (SEQ ID NO: 1 del2N - SEQ ID NO: 1 - PAdelFc2N - PAdelFc 
       - Cys)

<400>  39

Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
            20                  25                  30          


Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp 
        35                  40                  45              


Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp His Lys 
    50                  55                  60                  


Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu Thr Glu 
65                  70                  75                  80  


Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val 
                85                  90                  95      


Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser Gln Ala 
            100                 105                 110         


Pro Lys Ala Gln His Asp Lys Ile Gln Gln Ala Ala Asp Lys Glu Ile 
        115                 120                 125             


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln 
    130                 135                 140                 


Ser Leu Arg Asp Asp Pro Ser Val Ser Ala Glu Ile Leu Ala Glu Ala 
145                 150                 155                 160 


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ile Ala Ala Gln His Asp 
                165                 170                 175     


Lys Ile Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu 
            180                 185                 190         


Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln Ser Leu Arg Asp Asp Pro 
        195                 200                 205             


Ser Val Ser Ala Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
    210                 215                 220                 


Gln Ala Pro Lys Cys 
225                 


<210>  40
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of sFGFR3 binding protein and non-Ig binding 
       protein (SEQ ID NO: 1 dimer - PAdelFc dimer), CID 206079

<400>  40

Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile 
1               5                   10                  15      


Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala 
        115                 120                 125             


Asp Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Arg Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala 
                165                 170                 175     


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His 
            180                 185                 190         


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
        195                 200                 205             


Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
    210                 215                 220                 


Leu Asn Asp Ser Gln Ala Pro Lys Cys 
225                 230             


<210>  41
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of sFGFR3 binding protein and non-Ig binding 
       protein (SEQ ID NO: 2 del2N - SEQ ID NO: 2 - PAdelFc2N - PAdelFc 
       - Cys)

<400>  41

Ala Lys Phe Asp Gln His Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
            20                  25                  30          


Ser Asp Asp Thr Ser Val Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp 
        35                  40                  45              


Leu Asn Ala Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Gln His 
    50                  55                  60                  


Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys Leu Pro Asn Leu Thr Glu 
65                  70                  75                  80  


Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Thr Ser Val 
                85                  90                  95      


Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp Leu Asn Ala Ser Gln Ala 
            100                 105                 110         


Pro Lys Ala Gln His Asp Lys Ile Gln Gln Ala Ala Asp Lys Glu Ile 
        115                 120                 125             


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln 
    130                 135                 140                 


Ser Leu Arg Asp Asp Pro Ser Val Ser Ala Glu Ile Leu Ala Glu Ala 
145                 150                 155                 160 


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ile Ala Ala Gln His Asp 
                165                 170                 175     


Lys Ile Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu 
            180                 185                 190         


Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln Ser Leu Arg Asp Asp Pro 
        195                 200                 205             


Ser Val Ser Ala Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
    210                 215                 220                 


Gln Ala Pro Lys Cys 
225                 


<210>  42
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of sFGFR3 binding protein and non-Ig binding 
       protein (SEQ ID NO: 2 dimer - PAdelFc dimer - Cys)

<400>  42

Ile Ala Ala Lys Phe Asp Gln His Gln Ser Thr Ala Asp Glu Ile Ile 
1               5                   10                  15      


Leu Lys Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Thr Ser Val Ser Arg Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Leu Trp Leu Asn Ala Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Gln His Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Thr 
                85                  90                  95      


Ser Val Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp Leu Asn Ala Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala 
        115                 120                 125             


Asp Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Arg Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala 
                165                 170                 175     


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His 
            180                 185                 190         


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
        195                 200                 205             


Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
    210                 215                 220                 


Leu Asn Asp Ser Gln Ala Pro Lys Cys 
225                 230             


<210>  43
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein PAdelFc-SEQ1-SEQ1-PAdelFc; CID 206080

<400>  43

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala 
        115                 120                 125             


Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val 
145                 150                 155                 160 


Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala 
                165                 170                 175     


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His 
            180                 185                 190         


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
        195                 200                 205             


Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
    210                 215                 220                 


Leu Asn Asp Ser Gln Ala Pro Lys Cys 
225                 230             


<210>  44
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein of SEQ ID NO: 1 - SEQ ID NO: 2- PAdelFc-PAdelFc; 
       CID206081

<400>  44

Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile 
1               5                   10                  15      


Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Gln His Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Thr 
                85                  90                  95      


Ser Val Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp Leu Asn Ala Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala 
        115                 120                 125             


Asp Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Arg Asp Asp Pro Ser Val Ser Leu Glu Val 
145                 150                 155                 160 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala 
                165                 170                 175     


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His 
            180                 185                 190         


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
        195                 200                 205             


Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
    210                 215                 220                 


Leu Asn Asp Ser Gln Ala Pro Lys Cys 
225                 230             


<210>  45
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein of SEQ ID NO: 1 - PAdelFc - SEQ ID NO: 2- PAdelFc;
       CID206082

<400>  45

Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile 
1               5                   10                  15      


Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Gln His Gln Ser Thr Ala 
        115                 120                 125             


Asp Glu Ile Ile Leu Lys Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Thr Ser Val Ser Arg Glu Val 
145                 150                 155                 160 


Leu Tyr Glu Ala Leu Trp Leu Asn Ala Ser Gln Ala Pro Lys Ile Ala 
                165                 170                 175     


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His 
            180                 185                 190         


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
        195                 200                 205             


Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
    210                 215                 220                 


Leu Asn Asp Ser Gln Ala Pro Lys Cys 
225                 230             


<210>  46
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein of SEQ ID NO: 2 - PAdelFc - SEQ ID NO: 1 - 
       PAdelFc; CID206083

<400>  46

Ile Ala Ala Lys Phe Asp Gln His Gln Ser Thr Ala Asp Glu Ile Ile 
1               5                   10                  15      


Leu Lys Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Thr Ser Val Ser Arg Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Leu Trp Leu Asn Ala Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp His Lys Gln Ser Thr Ala 
        115                 120                 125             


Asp Thr Ile Ile Leu Glu Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn 
    130                 135                 140                 


Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val 
145                 150                 155                 160 


Leu Tyr Glu Ala Ile Trp Leu Asn Trp Ser Gln Ala Pro Lys Ile Ala 
                165                 170                 175     


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Tyr Glu Ile Leu His 
            180                 185                 190         


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
        195                 200                 205             


Arg Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
    210                 215                 220                 


Leu Asn Asp Ser Gln Ala Pro Lys Cys 
225                 230             


<210>  47
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 binding protein (204815 delN2)

<400>  47

Ala Lys Phe Asp His Lys Gln Ser Thr Ala Asp Thr Ile Ile Leu Glu 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
            20                  25                  30          


Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Tyr Glu Ala Ile Trp 
        35                  40                  45              


Leu Asn Trp Ser Gln Ala Pro Lys 
    50                  55      


<210>  48
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3 bindng protein (204783 delN2)

<400>  48

Ala Lys Phe Asp Gln His Gln Ser Thr Ala Asp Glu Ile Ile Leu Lys 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
            20                  25                  30          


Ser Asp Asp Thr Ser Val Ser Arg Glu Val Leu Tyr Glu Ala Leu Trp 
        35                  40                  45              


Leu Asn Ala Ser Gln Ala Pro Lys 
    50                  55      


