                               SEQUENCE LISTING

<110> MOMENTA PHARMACEUTICALS, INC.
 
<120> METHODS OF MAKING HYPER-SIALYLATED IMMUNOGLOBULIN

<130> 14131-0226WO1

<140> PCT/US2021/020898
<141> 2021-03-04

<150> 63/026,805
<151> 2020-05-19

<150> 62/985,467
<151> 2020-03-05

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 398
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210> 2
<211> 385
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Gly Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val 
1               5                   10                  15      


Cys Ala Leu His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg 
            20                  25                  30          


Asp Leu Ser Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln 
        35                  40                  45              


Gly Gly Ser Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu 
    50                  55                  60                  


Arg Thr Gly Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln 
65                  70                  75                  80  


Pro Arg Pro Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly 
                85                  90                  95      


Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu 
            100                 105                 110         


Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met 
        115                 120                 125             


Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln 
    130                 135                 140                 


Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val 
145                 150                 155                 160 


Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu 
                165                 170                 175     


His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln 
            180                 185                 190         


Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile 
        195                 200                 205             


Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys 
    210                 215                 220                 


Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro 
225                 230                 235                 240 


Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile 
                245                 250                 255     


Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr 
            260                 265                 270         


Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn 
        275                 280                 285             


Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile 
    290                 295                 300                 


Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala 
305                 310                 315                 320 


Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn 
                325                 330                 335     


Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr 
            340                 345                 350         


Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val 
        355                 360                 365             


Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro 
    370                 375                 380                 


Ser 
385 


<210> 3
<211> 357
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Arg Leu Val Phe Arg Gly Met Ser Ile Ser 
        275                 280                 285             


Arg Pro Asn Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg 
    290                 295                 300                 


Asp Lys Lys Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His 
305                 310                 315                 320 


Thr Lys Glu Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln 
                325                 330                 335     


Val Leu Asp Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp 
            340                 345                 350         


Ile Gly Thr Pro Ser 
        355         


<210> 4
<211> 225
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Tyr Glu Lys Ile Arg Arg Leu Leu 
    210                 215                 220                 


Trp 
225 


<210> 5
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg 
            20                  


<210> 6
<211> 20
<212> PRT
<213> Homo sapiens

<400> 6
Leu Leu Val Ala Val Cys Ala Leu His Leu Gly Val Thr Leu Val Tyr 
1               5                   10                  15      


Tyr Leu Ala Gly 
            20  


<210> 7
<211> 354
<212> PRT
<213> Homo sapiens

<400> 7
Arg Asp Leu Ser Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu 
1               5                   10                  15      


Gln Gly Gly Ser Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu 
            20                  25                  30          


Leu Arg Thr Gly Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser 
        35                  40                  45              


Gln Pro Arg Pro Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro 
    50                  55                  60                  


Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala 
65                  70                  75                  80  


Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
                85                  90                  95      


Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys 
            100                 105                 110         


Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys 
        115                 120                 125             


Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln 
    130                 135                 140                 


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg 
145                 150                 155                 160 


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr 
                165                 170                 175     


Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu 
            180                 185                 190         


Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
        195                 200                 205             


Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His 
    210                 215                 220                 


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
225                 230                 235                 240 


Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile 
                245                 250                 255     


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
            260                 265                 270         


Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn 
        275                 280                 285             


Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
    290                 295                 300                 


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
305                 310                 315                 320 


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp 
                325                 330                 335     


Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr 
            340                 345                 350         


Pro Ser 
        


<210> 8
<211> 290
<212> PRT
<213> Homo sapiens

<400> 8
Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala 
1               5                   10                  15      


Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
            20                  25                  30          


Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys 
        35                  40                  45              


Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys 
    50                  55                  60                  


Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln 
65                  70                  75                  80  


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg 
                85                  90                  95      


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr 
            100                 105                 110         


Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu 
        115                 120                 125             


Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
    130                 135                 140                 


Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His 
145                 150                 155                 160 


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
                165                 170                 175     


Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile 
            180                 185                 190         


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
        195                 200                 205             


Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn 
    210                 215                 220                 


Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
225                 230                 235                 240 


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
                245                 250                 255     


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp 
            260                 265                 270         


Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr 
        275                 280                 285             


Pro Ser 
    290 


<210> 9
<211> 406
<212> PRT
<213> Homo sapiens

<400> 9
Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210> 10
<211> 175
<212> PRT
<213> Homo sapiens

<400> 10
Met Asn Ser Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys Asp Ser 
1               5                   10                  15      


Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val Tyr His 
            20                  25                  30          


Ser Asp Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe Asn 
        35                  40                  45              


Asn Tyr Lys Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe Tyr Ile 
    50                  55                  60                  


Leu Lys Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu Ile 
65                  70                  75                  80  


Ser Pro Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met Leu Gly 
                85                  90                  95      


Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu Phe 
            100                 105                 110         


Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys Phe 
        115                 120                 125             


Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu Tyr Glu 
    130                 135                 140                 


Lys Asn Leu Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp Ile Tyr 
145                 150                 155                 160 


Leu Leu Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
                165                 170                 175 


<210> 11
<211> 9
<212> PRT
<213> Homo sapiens

<400> 11
Met Ile His Thr Asn Leu Lys Lys Lys 
1               5                   


<210> 12
<211> 17
<212> PRT
<213> Homo sapiens

<400> 12
Phe Ser Cys Cys Val Leu Val Phe Leu Leu Phe Ala Val Ile Cys Val 
1               5                   10                  15      


Trp 
    


<210> 13
<211> 380
<212> PRT
<213> Homo sapiens

<400> 13
Lys Glu Lys Lys Lys Gly Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr 
1               5                   10                  15      


Lys Glu Phe Gln Val Leu Lys Ser Leu Gly Lys Leu Ala Met Gly Ser 
            20                  25                  30          


Asp Ser Gln Ser Val Ser Ser Ser Ser Thr Gln Asp Pro His Arg Gly 
        35                  40                  45              


Arg Gln Thr Leu Gly Ser Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu 
    50                  55                  60                  


Ala Ser Phe Gln Val Trp Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile 
65                  70                  75                  80  


Pro Arg Leu Gln Lys Ile Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr 
                85                  90                  95      


Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu 
            100                 105                 110         


Ala Leu Arg Cys His Leu Arg Asp His Val Asn Val Ser Met Val Glu 
        115                 120                 125             


Val Thr Asp Phe Pro Phe Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro 
    130                 135                 140                 


Lys Glu Ser Ile Arg Thr Lys Ala Gly Pro Trp Gly Arg Cys Ala Val 
145                 150                 155                 160 


Val Ser Ser Ala Gly Ser Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile 
                165                 170                 175     


Asp Asp His Asp Ala Val Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn 
            180                 185                 190         


Phe Gln Gln Asp Val Gly Thr Lys Thr Thr Ile Arg Leu Met Asn Ser 
        195                 200                 205             


Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn 
    210                 215                 220                 


Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val Tyr His Ser Asp Ile 
225                 230                 235                 240 


Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys 
                245                 250                 255     


Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro 
            260                 265                 270         


Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu 
        275                 280                 285             


Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met Leu Gly Ile Ile Ile 
    290                 295                 300                 


Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser 
305                 310                 315                 320 


Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser 
                325                 330                 335     


Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu 
            340                 345                 350         


Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly 
        355                 360                 365             


Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
    370                 375                 380 


<210> 14
<211> 320
<212> PRT
<213> Homo sapiens

<400> 14
Ala Lys Pro Glu Ala Ser Phe Gln Val Trp Asn Lys Asp Ser Ser Ser 
1               5                   10                  15      


Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile Trp Lys Asn Tyr Leu Ser 
            20                  25                  30          


Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly Ile Lys 
        35                  40                  45              


Phe Ser Ala Glu Ala Leu Arg Cys His Leu Arg Asp His Val Asn Val 
    50                  55                  60                  


Ser Met Val Glu Val Thr Asp Phe Pro Phe Asn Thr Ser Glu Trp Glu 
65                  70                  75                  80  


Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr Lys Ala Gly Pro Trp Gly 
                85                  90                  95      


Arg Cys Ala Val Val Ser Ser Ala Gly Ser Leu Lys Ser Ser Gln Leu 
            100                 105                 110         


Gly Arg Glu Ile Asp Asp His Asp Ala Val Leu Arg Phe Asn Gly Ala 
        115                 120                 125             


Pro Thr Ala Asn Phe Gln Gln Asp Val Gly Thr Lys Thr Thr Ile Arg 
    130                 135                 140                 


Leu Met Asn Ser Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys Asp 
145                 150                 155                 160 


Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val Tyr 
                165                 170                 175     


His Ser Asp Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe 
            180                 185                 190         


Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe Tyr 
        195                 200                 205             


Ile Leu Lys Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu 
    210                 215                 220                 


Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met Leu 
225                 230                 235                 240 


Gly Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu 
                245                 250                 255     


Phe Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys 
            260                 265                 270         


Phe Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu Tyr 
        275                 280                 285             


Glu Lys Asn Leu Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp Ile 
    290                 295                 300                 


Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
305                 310                 315                 320 


<210> 15
<211> 339
<212> PRT
<213> Homo sapiens

<400> 15
Gly Ser Ser Pro Leu Leu Asp Met Leu Glu His His His His His His 
1               5                   10                  15      


His His Met Ala Lys Pro Glu Ala Ser Phe Gln Val Trp Asn Lys Asp 
            20                  25                  30          


Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile Trp Lys Asn 
        35                  40                  45              


Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro 
    50                  55                  60                  


Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu Arg Asp His 
65                  70                  75                  80  


Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe Asn Thr Ser 
                85                  90                  95      


Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr Lys Ala Gly 
            100                 105                 110         


Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser Leu Lys Ser 
        115                 120                 125             


Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val Leu Arg Phe 
    130                 135                 140                 


Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly Thr Lys Thr 
145                 150                 155                 160 


Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu Lys Arg Phe 
                165                 170                 175     


Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro 
            180                 185                 190         


Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr 
        195                 200                 205             


Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His Pro Asn Gln 
    210                 215                 220                 


Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu Trp Asp Ile 
225                 230                 235                 240 


Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser 
                245                 250                 255     


Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp 
            260                 265                 270         


Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr 
        275                 280                 285             


Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro 
    290                 295                 300                 


Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln Gly Thr Asp 
305                 310                 315                 320 


Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr 
                325                 330                 335     


Ile His Cys 
            


<210> 16
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210> 17
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp 
    210                 215                 220 


<210> 18
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Ser Met Lys Ile Glu Glu Gly Lys Leu Val 
            20                  25                  30          


Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly 
        35                  40                  45              


Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro 
    50                  55                  60                  


Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly 
65                  70                  75                  80  


Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln 
                85                  90                  95      


Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys 
            100                 105                 110         


Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile 
        115                 120                 125             


Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp 
    130                 135                 140                 


Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp 
145                 150                 155                 160 


Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln 
                165                 170                 175     


Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala 
            180                 185                 190         


Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp 
        195                 200                 205             


Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys 
    210                 215                 220                 


Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala 
225                 230                 235                 240 


Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp 
                245                 250                 255     


Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro 
            260                 265                 270         


Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala 
        275                 280                 285             


Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu 
    290                 295                 300                 


Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp 
305                 310                 315                 320 


Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala 
                325                 330                 335     


Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu 
            340                 345                 350         


Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg 
        355                 360                 365             


Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala 
    370                 375                 380                 


Leu Lys Asp Ala Gln Thr Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn 
385                 390                 395                 400 


Asn Asn Asn Asn Leu Gly Ile Glu Gly Arg 
                405                 410 


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 21
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210> 22
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys Gly Ser Met Gly Trp Asp Leu Thr Val Lys Met 
145                 150                 155                 160 


Leu Ala Gly Asn Glu Phe Gln Val Ser Leu Ser Ser Ser Met Ser Val 
                165                 170                 175     


Ser Glu Leu Lys Ala Gln Ile Thr Gln Lys Ile Gly Val His Ala Phe 
            180                 185                 190         


Gln Gln Arg Leu Ala Val His Pro Ser Gly Val Ala Leu Gln Asp Arg 
        195                 200                 205             


Val Pro Leu Ala Ser Gln Gly Leu Gly Pro Gly Ser Thr Val Leu Leu 
    210                 215                 220                 


Val Val Asp Lys Cys Asp Glu Pro Leu Asn Ile Leu Val Arg Asn Asn 
225                 230                 235                 240 


Lys Gly Arg Ser Ser Thr Tyr Glu Val Arg Leu Thr Gln Thr Val Ala 
                245                 250                 255     


His Leu Lys Gln Gln Val Ser Gly Leu Glu Gly Val Gln Asp Asp Leu 
            260                 265                 270         


Phe Trp Leu Thr Phe Glu Gly Lys Pro Leu Glu Asp Gln Leu Pro Leu 
        275                 280                 285             


Gly Glu Tyr Gly Leu Lys Pro Leu Ser Thr Val Phe Met Asn Leu Arg 
    290                 295                 300                 


Leu Arg Gly Gly 
305             


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 26
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      4xHis tag

<400> 26
His His His His 
1               


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      5xHis tag

<400> 27
His His His His His 
1               5   


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 28
His His His His His His 
1               5       


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      7xHis tag

<400> 29
His His His His His His His 
1               5           


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      8xHis tag

<400> 30
His His His His His His His His 
1               5               


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      9xHis tag

<400> 31
His His His His His His His His His 
1               5                   


<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 32
His His His His His His His His His His 
1               5                   10  


<210> 33
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Pro Arg Asp 
1           


<210> 34
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Pro Gly Gly 
1           


<210> 35
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala 
1               5                   10                  15      


Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
            20                  25                  30          


Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys 
        35                  40                  45              


Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys 
    50                  55                  60                  


Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln 
65                  70                  75                  80  


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg 
                85                  90                  95      


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr 
            100                 105                 110         


Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu 
        115                 120                 125             


Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
    130                 135                 140                 


Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His 
145                 150                 155                 160 


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
                165                 170                 175     


Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile 
            180                 185                 190         


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
        195                 200                 205             


Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn 
    210                 215                 220                 


Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
225                 230                 235                 240 


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
                245                 250                 255     


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp 
            260                 265                 270         


Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr 
        275                 280                 285             


Pro Ser Pro Arg Asp 
    290             


<210> 36
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala 
1               5                   10                  15      


Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
            20                  25                  30          


Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys 
        35                  40                  45              


Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys 
    50                  55                  60                  


Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln 
65                  70                  75                  80  


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg 
                85                  90                  95      


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr 
            100                 105                 110         


Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu 
        115                 120                 125             


Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
    130                 135                 140                 


Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His 
145                 150                 155                 160 


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
                165                 170                 175     


Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile 
            180                 185                 190         


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
        195                 200                 205             


Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn 
    210                 215                 220                 


Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
225                 230                 235                 240 


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
                245                 250                 255     


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp 
            260                 265                 270         


Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr 
        275                 280                 285             


Pro Ser Pro Gly Gly 
    290             


<210> 37
<211> 302
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr 
1               5                   10                  15      


Ala Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly 
            20                  25                  30          


Pro Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala 
        35                  40                  45              


Lys Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp 
    50                  55                  60                  


Cys Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg 
65                  70                  75                  80  


Gln Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln 
                85                  90                  95      


Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp 
            100                 105                 110         


Thr Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala 
        115                 120                 125             


Leu Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu 
    130                 135                 140                 


Ile Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg 
145                 150                 155                 160 


His Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val 
                165                 170                 175     


Gln Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr 
            180                 185                 190         


Ile Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp 
        195                 200                 205             


Asp Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro 
    210                 215                 220                 


Asn Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys 
225                 230                 235                 240 


Lys Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys 
                245                 250                 255     


Glu Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu 
            260                 265                 270         


Asp Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly 
        275                 280                 285             


Thr Pro Ser Pro Gly Gly His His His His His His His His 
    290                 295                 300         


<210> 38
<211> 301
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr 
1               5                   10                  15      


Ala Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly 
            20                  25                  30          


Pro Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala 
        35                  40                  45              


Lys Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp 
    50                  55                  60                  


Cys Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg 
65                  70                  75                  80  


Gln Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln 
                85                  90                  95      


Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp 
            100                 105                 110         


Thr Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala 
        115                 120                 125             


Leu Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu 
    130                 135                 140                 


Ile Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg 
145                 150                 155                 160 


His Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val 
                165                 170                 175     


Gln Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr 
            180                 185                 190         


Ile Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp 
        195                 200                 205             


Asp Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro 
    210                 215                 220                 


Asn Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys 
225                 230                 235                 240 


Lys Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys 
                245                 250                 255     


Glu Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu 
            260                 265                 270         


Asp Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly 
        275                 280                 285             


Thr Pro Ser Pro Arg Asp His His His His His His His 
    290                 295                 300     


<210> 39
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr 
1               5                   10                  15      


Ala Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly 
            20                  25                  30          


Pro Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala 
        35                  40                  45              


Lys Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp 
    50                  55                  60                  


Cys Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg 
65                  70                  75                  80  


Gln Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln 
                85                  90                  95      


Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp 
            100                 105                 110         


Thr Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala 
        115                 120                 125             


Leu Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu 
    130                 135                 140                 


Ile Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg 
145                 150                 155                 160 


His Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val 
                165                 170                 175     


Gln Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr 
            180                 185                 190         


Ile Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp 
        195                 200                 205             


Asp Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro 
    210                 215                 220                 


Asn Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys 
225                 230                 235                 240 


Lys Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys 
                245                 250                 255     


Glu Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu 
            260                 265                 270         


Asp Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly 
        275                 280                 285             


Thr Pro Ser Pro Gly Gly 
    290                 


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
1               5                   


<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Glu Glu Gln Phe Asn Ser Thr Phe Arg 
1               5                   


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Glu Glu Gln Tyr Asn Ser Thr Phe Arg 
1               5                   


<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
1               5                   


<210> 44
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(20)
<223> This sequence may encompass 3-20 residues

<400> 44
His His His His His His His His His His His His His His His His 
1               5                   10                  15      


His His His His 
            20  


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(8)
<223> This sequence may encompass 7-8 residues

<400> 45
His His His His His His His His 
1               5               


<210> 46
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Gly Ser Ser Pro Leu Leu Asp Met Gly Pro Ala Ser Asn Leu Thr Ser 
1               5                   10                  15      


Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro Ala Cys Pro Glu 
            20                  25                  30          


Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu Phe Asn Met Pro 
        35                  40                  45              


Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn Val Lys Met Gly 
    50                  55                  60                  


Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His Lys Val Ala Ile 
65                  70                  75                  80  


Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys Tyr Trp Leu Tyr 
                85                  90                  95      


Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr 
            100                 105                 110         


Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg Ala Lys Leu Leu 
        115                 120                 125             


Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp Tyr Thr Cys Phe 
    130                 135                 140                 


Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp His Asn Ala Tyr 
145                 150                 155                 160 


Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala Met Asp Lys Phe 
                165                 170                 175     


Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly Val Ser Ala Leu 
            180                 185                 190         


Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro Asn Asn Tyr Trp 
        195                 200                 205             


Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg Leu Val Phe Arg 
    210                 215                 220                 


Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly Arg Cys Arg Met 
225                 230                 235                 240 


Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn Pro Gln Arg Phe 
                245                 250                 255     


Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser Asp Gly Leu Asn 
            260                 265                 270         


Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr Pro Leu Tyr Thr 
        275                 280                 285             


Gln Ile Thr Val Asp Ile Gly Thr Pro Ser Pro Arg Asp His His His 
    290                 295                 300                 


His His His His 
305             


