                         SEQUENCE LISTING

<110>  Ohio State Innovation Foundation
 
<120>  DESIGNER EXTRACELLULAR VESICLES FOR TREATING EXCITOTOXICITY

<130>  321501-2470

<150>  US 62/990,783
<151>  2020-03-17

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2496
<212>  DNA
<213>  Mus musculus

<400>  1
atgtccggga agggaggctg ggcctggtgg tgggcccggc tgcccctctg cctactcctc       60

agcctttatg gctcctgggt gccttcatcc ctaggaaagc ccaagggtca cccccacatg      120

aactctatcc gtatcgatgg agacatcacc ctgggaggcc tgtttcccgt ccacggtcgc      180

ggctccgagg gcaaggcctg cggcgagttg aagaaggaga aaggtatcca ccggctggag      240

gccatgctct ttgccctgga ccgcatcaac aacgacccgg acctactgcc caacatcacg      300

ttgggcgccc gcattctgga cacctgctca agggataccc acgccctgga gcagtccctg      360

acctttgtgc aggcgctcat cgagaaggac ggcacggagg tccgctgcgg cagcgggggc      420

ccacccatca tcaccaagcc tgaacgagtg gtgggtgtca tcggagcttc ggggagctcc      480

gtctcgatca tggtggccaa catcctccgc ctcttcaaga tcccccagat cagctacgcc      540

tccacggctc ccgacttgag tgataacagc cgctatgact tcttctcccg ggtcgtgccc      600

tcggacacat accaggccca ggccatggtg gacatcgtcc gggccctcaa gtggaactat      660

gtgtccacgc tggcctcaga gggtagctac ggcgagagcg gcgtggaggc ctttatccag      720

aagtcccgag agaacggagg cgtgtgcatt gcccagtcgg tgaagattcc acgggaaccc      780

aagaccgggg agtttgacaa gatcatcaaa cgccttctgg aaacgtccaa tgccagagcc      840

atcatcatct ttgccaacga ggatgatatc aggagggtgc tggaggcagc gcgcagggcc      900

aaccagaccg gccacttctt ttggatgggt tctgatagct ggggctccaa gagcgccccc      960

gtgctgcgcc ttgaggaagt ggctgaaggt gcagtcacca ttcttcccaa gaggacgtct     1020

gtgcgagggt ttgaccgata cttctccagc cgcacgcttg acaacaacag gcgcaacatc     1080

tggtttgctg agttctggga ggacaacttc cattgcaagt tgagccgcca cgcgctcaag     1140

aagggaagcc acatcaagaa gtgcaccaac cgagagcgca tcgggcagga ctcggcctac     1200

gaacaggagg ggaaggtgca gtttgtgatc gacgccgtgt acgccatggg ccatgctctg     1260

cacgccatgc atcgtgacct gtgtcccggc cgcgtaggac tctgccctcg aatggaccct     1320

gtggatggca cccagctgct taagtacatc agaaacgtca acttctcagg catcgccggg     1380

aacccggtga ccttcaacga gaacggagac gcgccagggc gttatgacat ctaccagtac     1440

caacgtcgca acggctcggc tgagtacaag gtcatcggct catggacaga ccacttgcac     1500

ctcagaatag agcggatgca gtggccaggg agtggccagc agctgccacg ctccatctgc     1560

agcctgccct gccagccagg cgagcggaag aagacggtga agggcatggc ttgctgctgg     1620

cactgcgagc cctgcacggg gtaccagtac caggtggacc gctacacctg taagacctgc     1680

ccctatgaca tgcggcccac ggagaaccgc acgagctgcc agcccatacc cattgtcaag     1740

ttggagtggg actcaccctg ggctgtgctg cccctcttcc tggctgtggt gggcattgct     1800

gccacgctgt tcgtggtggt cacttttgtg cgctacaacg acactccgat cgtcaaggcc     1860

tcgggccggg agctgagcta cgtcctgctg gcgggcatct ttctctgcta tgccaccacc     1920

ttcctcatga tcgcagagcc tgacctgggg acctgttcac tccgccgcat cttcctgggg     1980

cttggcatga gcatcagcta cgcggccctg ctgaccaaga ccaaccgcat ctaccgcatc     2040

tttgagcagg gcaagcggtc ggtcagcgcc ccacggttca tcagccccgc ctcgcagctg     2100

gccatcacct tcgtcctcat ctcgctgcag ttgcttggca tctgcgtgtg gttcgtggtg     2160

gacccctccc actcggtggt ggacttccag gaccagcgga cacttgaccc ccgcttcgcc     2220

cggggtgtgc tcaagtgtga catctcggac ctgtcgctca tctgcctcct gggctacagc     2280

atgctgctga tggtcacgtg tactgtgtat gccatcaaga ctcgaggcgt gcctgagacc     2340

ttcaatgagg ccaagcccat cggcttcacc atgtacacca cctgcatcgt ctggctggcc     2400

ttcatcccca tcttttttgg cacctcgcag tcggctgaca aggtaacctc tgaggccctg     2460

cccgtggaat tcagcccgcc attgctggca cataat                               2496


<210>  2
<211>  832
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Gly Lys Gly Gly Trp Ala Trp Trp Trp Ala Arg Leu Pro Leu 
1               5                   10                  15      


Cys Leu Leu Leu Ser Leu Tyr Gly Ser Trp Val Pro Ser Ser Leu Gly 
            20                  25                  30          


Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
        35                  40                  45              


Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
    50                  55                  60                  


Lys Ala Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
        115                 120                 125             


Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
    130                 135                 140                 


Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
225                 230                 235                 240 


Lys Ser Arg Glu Asn Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                245                 250                 255     


Pro Arg Glu Pro Lys Thr Gly Glu Phe Asp Lys Ile Ile Lys Arg Leu 
            260                 265                 270         


Leu Glu Thr Ser Asn Ala Arg Ala Ile Ile Ile Phe Ala Asn Glu Asp 
        275                 280                 285             


Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
    290                 295                 300                 


His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ser Ala Pro 
305                 310                 315                 320 


Val Leu Arg Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                325                 330                 335     


Lys Arg Thr Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
            340                 345                 350         


Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
        355                 360                 365             


Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
    370                 375                 380                 


Ile Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
385                 390                 395                 400 


Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                405                 410                 415     


Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
            420                 425                 430         


Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
        435                 440                 445             


Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
    450                 455                 460                 


Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
465                 470                 475                 480 


Gln Arg Arg Asn Gly Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                485                 490                 495     


Asp His Leu His Leu Arg Ile Glu Arg Met Gln Trp Pro Gly Ser Gly 
            500                 505                 510         


Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
        515                 520                 525             


Arg Lys Lys Thr Val Lys Gly Met Ala Cys Cys Trp His Cys Glu Pro 
    530                 535                 540                 


Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
545                 550                 555                 560 


Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Ser Cys Gln Pro Ile 
                565                 570                 575     


Pro Ile Val Lys Leu Glu Trp Asp Ser Pro Trp Ala Val Leu Pro Leu 
            580                 585                 590         


Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Val Thr 
        595                 600                 605             


Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
    610                 615                 620                 


Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
625                 630                 635                 640 


Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                645                 650                 655     


Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
            660                 665                 670         


Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
        675                 680                 685             


Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
    690                 695                 700                 


Val Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
705                 710                 715                 720 


Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                725                 730                 735     


Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
            740                 745                 750         


Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
        755                 760                 765             


Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
    770                 775                 780                 


Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
785                 790                 795                 800 


Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Val Thr 
                805                 810                 815     


Ser Glu Ala Leu Pro Val Glu Phe Ser Pro Pro Leu Leu Ala His Asn 
            820                 825                 830         


<210>  3
<211>  2724
<212>  DNA
<213>  Mus musculus

<400>  3
atggtttgtg agggaaagcg ctcaacctct tgcccttgtt tcttcctttt gactgccaag       60

ttctactgga tcctcacaat gatgcaaaga actcacagcc aggagtatgc gcattccatc      120

cgcctggatg gggacatcat tttggggggt ctttttcctg ttcatgccaa gggagaaaga      180

ggggtgcctt gtggggacct gaagaaggaa aagggcatcc acagacttga ggccatgctt      240

tatgcaatcg accagattaa taaggacccc gatctcctct ccaatatcac tctgggtgtc      300

cggatccttg acacatgttc cagggacacc tatgctttgg agcagtcact aaccttcgtg      360

caggcactga tagagaaaga cgcgtctgac gtgaagtgtg ctaatggaga cccacccata      420

ttcaccaagc ccgacaagat ttctggtgtc ataggtgctg cagcaagctc cgtgtccatc      480

atggtggcta acattttaag actttttaag atacctcaga ttagctatgc atctacagcc      540

ccagagctaa gtgacaacac caggtatgat ttcttttctc gggtggtccc gcctgactcc      600

taccaagccc aagccatggt ggacattgtg acagccctgg gatggaatta tgtgtcaaca      660

ctggcttccg aggggaacta tggagagagt ggtgttgagg ccttcactca gatctcaagg      720

gagattggtg gtgtttgcat tgctcaatca cagaaaatcc cacgtgaacc aagacctgga      780

gaattcgaaa aaattatcaa acgcctgctg gagacaccca acgctcgcgc agtgattatg      840

tttgccaatg aggatgacat caggaggata ttggaagcag caaaaaaatt aaaccagagt      900

gggcattttc tatggattgg ctcagatagt tggggatcca aaatagcacc tgtctatcag      960

caggaggaga tcgccgaagg agctgtgaca attttgccca aaagagcatc aattgatggg     1020

tttgaccgat actttagaag ccgaactctt gccaataatc gaagaaatgt gtggtttgca     1080

gaattttggg aggagaattt tggatgcaaa ttaggatcac atgggaagag gaacagtcat     1140

ataaagaaat gcacagggct ggagcgaatt gcacgggatt catcttacga acaagaagga     1200

aaggttcaat ttgtaattga tgcagtgtat tccatggctt atgcactgca caacatgcac     1260

aaagaactct gccctggtta cataggcctt tgcccaagga tggttaccat cgatgggaaa     1320

gagctactgg gttacatcag ggccgtgaat tttaatggca gcgctggtac acctgtcact     1380

tttaatgaga atggagatgc tccgggacgc tacgatatct tccaatatca gataaacaac     1440

aaaagtacag aatacaaaat catcggccac tggaccaatc aacttcacct aaaagtggaa     1500

gacatgcagt gggctaatag agagcacacg cacccagcat ctgtctgcag cctgccgtgc     1560

aagcctgggg agaggaagaa aaccgtgaaa ggggtccctt gctgctggca ctgtgaacgc     1620

tgcgagggtt ataactacca ggtggacgaa ctctcctgtg aactctgccc tttggatcag     1680

agaccaaaca tcaaccgcac tggctgccag aggattccca tcatcaagtt ggagtggcat     1740

tcaccctggg ccgtggtacc tgtgttcata gcaatattgg gaatcattgc caccaccttt     1800

gtgattgtga cctttgtccg ctataatgac acaccaatcg tgagagcttc tgggcgggaa     1860

cttagttatg tgctcctaac ggggattttt ctctgttact caatcacttt tttgatgatt     1920

gcggcacctg acacaatcat ctgctctttc cgaaggatct tcctgggact tggtatgtgt     1980

ttcagctatg cagcactttt gaccaaaaca aaccgtatcc accgaatatt cgagcaaggg     2040

aagaaatctg tcacagcacc taagttcatc agcccagcat cccagctggt gatcaccttc     2100

agcctcatct ccgtacagct ccttggagtg tttgtgtggt ttgtcgtgga tcccccccac     2160

accatcattg actatggaga acagcgaaca ctggatcccg agaacgccag gggagtgctc     2220

aagtgtgaca tttccgatct gtcactcatt tgttcactgg gatacagtat cctcctgatg     2280

gtcacttgta ctgtttatgc cattaaaacc agaggggttc cagaaacgtt caatgaagcc     2340

aaacctattg gatttaccat gtacaccacg tgcatcattt ggttagcttt cattcccatc     2400

ttttttggta cagcccagtc agcagaaaag atgtacatcc agacaacaac acttactgtc     2460

tccatgagtt taagtgcttc agtgtctctg ggaatgctct atatgcccaa agtttatatt     2520

ataatttttc atccagagca gaacgttcaa aaacgcaaga gaagcttcaa ggctgtggtc     2580

acggccgcta ccatgcaaag caaactgatc caaaagggaa atgacagacc aaacggcgag     2640

gtgaaaagtg aactctgtga gagtcttgaa accaacagta agtcatctgt agactttcag     2700

atggtcaaga gcgggagcac ttcc                                            2724


<210>  4
<211>  908
<212>  PRT
<213>  Mus musculus

<400>  4

Met Val Cys Glu Gly Lys Arg Ser Thr Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Leu Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Asp Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Glu Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Val Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Asn Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Ile Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala Asn Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Ile Asn Arg Thr Gly Cys Gln Arg Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Ile Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Ile Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Thr Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Asn Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Ser Lys Ser Ser 
                885                 890                 895     


Val Asp Phe Gln Met Val Lys Ser Gly Ser Thr Ser 
            900                 905             


<210>  5
<211>  2736
<212>  DNA
<213>  Homo sapiens

<400>  5
atgcctggga agagaggctt gggctggtgg tgggcccggc tgcccctttg cctgctcctc       60

agcctttacg gcccctggat gccttcctcc ctgggaaagc ccaaaggcca ccctcacatg      120

aattccatcc gcatagatgg ggacatcaca ctgggaggcc tgttcccggt gcatggccgg      180

ggctcagagg gcaagccctg tggagaactt aagaaggaaa agggcatcca ccggctggag      240

gccatgctgt tcgccctgga tcgcatcaac aacgacccgg acctgctgcc taacatcacg      300

ctgggcgccc gcattctgga cacctgctcc agggacaccc atgccctcga gcagtcgctg      360

acctttgtgc aggcgctcat cgagaaggat ggcacagagg tccgctgtgg cagtggcggc      420

ccacccatca tcaccaagcc tgaacgtgtg gtgggtgtca tcggtgcttc agggagctcg      480

gtctccatca tggtggccaa catccttcgc ctcttcaaga taccccagat cagctacgcc      540

tccacagcgc cagacctgag tgacaacagc cgctacgatt tcttctcccg cgtggtgccc      600

tcggacacgt accaggccca ggccatggtg gacatcgtcc gtgccctcaa gtggaactat      660

gtgtccacag tggcctcgga gggcagctat ggtgagagcg gtgtggaggc cttcatccag      720

aagtcccgtg aggacggggg cgtgtgcatc gcccagtcgg tgaagatacc acgggagccc      780

aaggcaggcg agttcgacaa gatcatccgc cgcctcctgg agacttcgaa cgccagggca      840

gtcatcatct ttgccaacga ggatgacatc aggcgtgtgc tggaggcagc acgaagggcc      900

aaccagacag gccatttctt ctggatgggc tctgacagct ggggctccaa gattgcacct      960

gtgctgcacc tggaggaggt ggctgagggt gctgtcacga tcctccccaa gaggatgtcc     1020

gtacgaggct tcgaccgcta cttctccagc cgcacgctgg acaacaaccg gcgcaacatc     1080

tggtttgccg agttctggga ggacaacttc cactgcaagc tgagccgcca cgccctcaag     1140

aagggcagcc acgtcaagaa gtgcaccaac cgtgagcgaa ttgggcagga ttcagcttat     1200

gagcaggagg ggaaggtgca gtttgtgatc gatgccgtgt acgccatggg ccacgcgctg     1260

cacgccatgc accgtgacct gtgtcccggc cgcgtggggc tctgcccgcg catggaccct     1320

gtagatggca cccagctgct taagtacatc cgaaacgtca acttctcagg catcgcaggg     1380

aaccctgtga ccttcaatga gaatggagat gcgcctgggc gctatgacat ctaccaatac     1440

cagctgcgca acgattctgc cgagtacaag gtcattggct cctggactga ccacctgcac     1500

cttagaatag agcggatgca ctggccgggg agcgggcagc agctgccccg ctccatctgc     1560

agcctgccct gccaaccggg tgagcggaag aagacagtga agggcatgcc ttgctgctgg     1620

cactgcgagc cttgcacagg gtaccagtac caggtggacc gctacacctg taagacgtgt     1680

ccctatgaca tgcggcccac agagaaccgc acgggctgcc ggcccatccc catcatcaag     1740

cttgagtggg gctcgccctg ggccgtgctg cccctcttcc tggccgtggt gggcatcgct     1800

gccacgttgt tcgtggtgat cacctttgtg cgctacaacg acacgcccat cgtcaaggcc     1860

tcgggccgtg aactgagcta cgtgctgctg gcaggcatct tcctgtgcta tgccaccacc     1920

ttcctcatga tcgctgagcc cgaccttggc acctgctcgc tgcgccgaat cttcctggga     1980

ctagggatga gcatcagcta tgcagccctg ctcaccaaga ccaaccgcat ctaccgcatc     2040

ttcgagcagg gcaagcgctc ggtcagtgcc ccacgcttca tcagccccgc ctcacagctg     2100

gccatcacct tcagcctcat ctcgctgcag ctgctgggca tctgtgtgtg gtttgtggtg     2160

gacccctccc actcggtggt ggacttccag gaccagcgga cactcgaccc ccgcttcgcc     2220

aggggtgtgc tcaagtgtga catctcggac ctgtcgctca tctgcctgct gggctacagc     2280

atgctgctca tggtcacgtg caccgtgtat gccatcaaga cacgcggcgt gcccgagacc     2340

ttcaatgagg ccaagcccat tggcttcacc atgtacacca cttgcatcgt ctggctggcc     2400

ttcatcccca tcttctttgg cacctcgcag tcggccgaca agctgtacat ccagacgacg     2460

acgctgacgg tctcggtgag tctgagcgcc tcggtgtccc tgggaatgct ctacatgccc     2520

aaagtctaca tcatcctctt ccacccggag cagaatgtgc ccaagcgcaa gcgcagcctc     2580

aaagccgtcg ttacggcggc caccatgtcc aacaagttca cgcagaaggg caacttccgg     2640

cccaacggag aggccaagtc tgagctctgc gagaaccttg aggccccagc gctggccacc     2700

aaacagactt acgtcactta caccaaccat gcaatc                               2736


<210>  6
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
1               5                   10                  15      


Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
            20                  25                  30          


Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
        35                  40                  45              


Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
    50                  55                  60                  


Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
        115                 120                 125             


Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
    130                 135                 140                 


Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
225                 230                 235                 240 


Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                245                 250                 255     


Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
            260                 265                 270         


Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
        275                 280                 285             


Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
    290                 295                 300                 


His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
305                 310                 315                 320 


Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                325                 330                 335     


Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
            340                 345                 350         


Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
        355                 360                 365             


Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
    370                 375                 380                 


Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
385                 390                 395                 400 


Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                405                 410                 415     


Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
            420                 425                 430         


Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
        435                 440                 445             


Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
    450                 455                 460                 


Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
465                 470                 475                 480 


Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                485                 490                 495     


Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
            500                 505                 510         


Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
        515                 520                 525             


Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
    530                 535                 540                 


Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
545                 550                 555                 560 


Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                565                 570                 575     


Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
            580                 585                 590         


Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
        595                 600                 605             


Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
    610                 615                 620                 


Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
625                 630                 635                 640 


Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                645                 650                 655     


Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
            660                 665                 670         


Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
        675                 680                 685             


Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
    690                 695                 700                 


Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
705                 710                 715                 720 


Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                725                 730                 735     


Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
            740                 745                 750         


Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
        755                 760                 765             


Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
    770                 775                 780                 


Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
785                 790                 795                 800 


Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                805                 810                 815     


Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
            820                 825                 830         


Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
        835                 840                 845             


Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
    850                 855                 860                 


Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
865                 870                 875                 880 


Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                885                 890                 895     


Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
            900                 905                 910         


<210>  7
<211>  2724
<212>  DNA
<213>  Homo sapiens

<400>  7
atggtatgcg agggaaagcg atcagcctct tgcccttgtt tcttcctctt gaccgccaag       60

ttctactgga tcctcacaat gatgcaaaga actcacagcc aggagtatgc ccattccata      120

cgggtggatg gggacattat tttggggggt ctcttccctg tccacgcaaa gggagagaga      180

ggggtgcctt gtggggagct gaagaaggaa aaggggattc acagactgga ggccatgctt      240

tatgcaattg accagattaa caaggaccct gatctccttt ccaacatcac tctgggtgtc      300

cgcatcctcg acacgtgctc tagggacacc tatgctttgg agcagtctct aacattcgtg      360

caggcattaa tagagaaaga tgcttcggat gtgaagtgtg ctaatggaga tccacccatt      420

ttcaccaagc ccgacaagat ttctggcgtc ataggtgctg cagcaagctc cgtgtccatc      480

atggttgcta acattttaag actttttaag atacctcaaa tcagctatgc atccacagcc      540

ccagagctaa gtgataacac caggtatgac tttttctctc gagtggttcc gcctgactcc      600

taccaagccc aagccatggt ggacatcgtg acagcactgg gatggaatta tgtttcgaca      660

ctggcttctg aggggaacta tggtgagagc ggtgtggagg ccttcaccca gatctcgagg      720

gagattggtg gtgtttgcat tgctcagtca cagaaaatcc cacgtgaacc aagacctgga      780

gaatttgaaa aaattatcaa acgcctgcta gaaacaccta atgctcgagc agtgattatg      840

tttgccaatg aggatgacat caggaggata ttggaagcag caaaaaaact aaaccaaagt      900

gggcattttc tctggattgg ctcagatagt tggggatcca aaatagcacc tgtctatcag      960

caagaggaga ttgcagaagg ggctgtgaca attttgccca aacgagcatc aattgatgga     1020

tttgatcgat actttagaag ccgaactctt gccaataatc gaagaaatgt gtggtttgca     1080

gaattctggg aggagaattt tggctgcaag ttaggatcac atgggaaaag gaacagtcat     1140

ataaagaaat gcacagggct ggagcgaatt gctcgggatt catcttatga acaggaagga     1200

aaggtccaat ttgtaattga tgctgtatat tccatggctt acgccctgca caatatgcac     1260

aaagatctct gccctggata cattggcctt tgtccacgaa tgagtaccat tgatgggaaa     1320

gagctacttg gttatattcg ggctgtaaat tttaatggca gtgctggcac tcctgtcact     1380

tttaatgaaa acggagatgc tcctggacgt tatgatatct tccagtatca aataaccaac     1440

aaaagcacag agtacaaagt catcggccac tggaccaatc agcttcatct aaaagtggaa     1500

gacatgcagt gggctcatag agaacatact cacccggcgt ctgtctgcag cctgccgtgt     1560

aagccagggg agaggaagaa aacggtgaaa ggggtccctt gctgctggca ctgtgaacgc     1620

tgtgaaggtt acaactacca ggtggatgag ctgtcctgtg aactttgccc tctggatcag     1680

agacccaaca tgaaccgcac aggctgccag cttatcccca tcatcaaatt ggagtggcat     1740

tctccctggg ctgtggtgcc tgtgtttgtt gcaatattgg gaatcatcgc caccaccttt     1800

gtgatcgtga cctttgtccg ctataatgac acacctatcg tgagggcttc aggacgcgaa     1860

cttagttacg tgctcctaac ggggattttt ctctgttatt caatcacgtt tttaatgatt     1920

gcagcaccag atacaatcat atgctccttc cgacgggtct tcctaggact tggcatgtgt     1980

ttcagctatg cagcccttct gaccaaaaca aaccgtatcc accgaatatt tgagcagggg     2040

aagaaatctg tcacagcgcc caagttcatt agtccagcat ctcagctggt gatcaccttc     2100

agcctcatct ccgtccagct ccttggagtg tttgtctggt ttgttgtgga tcccccccac     2160

atcatcattg actatggaga gcagcggaca ctagatccag agaaggccag gggagtgctc     2220

aagtgtgaca tttctgatct ctcactcatt tgttcacttg gatacagtat cctcttgatg     2280

gtcacttgta ctgtttatgc cattaaaacg agaggtgtcc cagagacttt caatgaagcc     2340

aaacctattg gatttaccat gtataccacc tgcatcattt ggttagcttt catccccatc     2400

ttttttggta cagcccagtc agcagaaaag atgtacatcc agacaacaac acttactgtc     2460

tccatgagtt taagtgcttc agtatctctg ggcatgctct atatgcccaa ggtttatatt     2520

ataatttttc atccagaaca gaatgttcaa aaacgcaaga ggagcttcaa ggctgtggtg     2580

acagctgcca ccatgcaaag caaactgatc caaaaaggaa atgacagacc aaatggcgag     2640

gtgaaaagtg aactctgtga gagtcttgaa accaacactt cctctaccaa gacaacatat     2700

atcagttaca gcaatcattc aatc                                            2724


<210>  8
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr Ser Ser Thr 
                885                 890                 895     


Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile 
            900                 905             


<210>  9
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210>  10
<211>  1246
<212>  DNA
<213>  Homo sapiens

<400>  10
gaccagccta cagccgcctg catctgtatc cagcgccagg tcccgccagt cccagctgcg       60

cgcgcccccc agtcccgcac ccgttcggcc caggctaagt tagccctcac catgccggtc      120

aaaggaggca ccaagtgcat caaatacctg ctgttcggat ttaacttcat cttctggctt      180

gccgggattg ctgtccttgc cattggacta tggctccgat tcgactctca gaccaagagc      240

atcttcgagc aagaaactaa taataataat tccagcttct acacaggagt ctatattctg      300

atcggagccg gcgccctcat gatgctggtg ggcttcctgg gctgctgcgg ggctgtgcag      360

gagtcccagt gcatgctggg actgttcttc ggcttcctct tggtgatatt cgccattgaa      420

atagctgcgg ccatctgggg atattcccac aaggatgagg tgattaagga agtccaggag      480

ttttacaagg acacctacaa caagctgaaa accaaggatg agccccagcg ggaaacgctg      540

aaagccatcc actatgcgtt gaactgctgt ggtttggctg ggggcgtgga acagtttatc      600

tcagacatct gccccaagaa ggacgtactc gaaaccttca ccgtgaagtc ctgtcctgat      660

gccatcaaag aggtcttcga caataaattc cacatcatcg gcgcagtggg catcggcatt      720

gccgtggtca tgatatttgg catgatcttc agtatgatct tgtgctgtgc tatccgcagg      780

aaccgcgaga tggtctagag tcagcttaca tccctgagca ggaaagttta cccatgaaga      840

ttggtgggat tttttgtttg tttgttttgt tttgtttgtt gtttgttgtt tgtttttttg      900

ccactaattt tagtattcat tctgcattgc tagataaaag ctgaagttac tttatgtttg      960

tcttttaatg cttcattcaa tattgacatt tgtagttgag cggggggttt ggtttgcttt     1020

ggtttatatt ttttcagttg tttgtttttg cttgttatat taagcagaaa tcctgcaatg     1080

aaaggtacta tatttgctag actctagaca agatattgta cataaaagaa tttttttgtc     1140

tttaaataga tacaaatgtc tatcaacttt aatcaagttg taacttatat tgaagacaat     1200

ttgatacata ataaaaaatt atgacaatgt caaaaaaaaa aaaaaa                    1246


<210>  11
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  12
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  12
atggcggtgg aaggaggaat gaaatgtgtg aagttcttgc tctacgtcct cctgctggcc       60

ttttgcgcct gtgcagtggg actgattgcc gtgggtgtcg gggcacagct tgtcctgagt      120

cagaccataa tccagggggc tacccctggc tctctgttgc cagtggtcat catcgcagtg      180

ggtgtcttcc tcttcctggt ggcttttgtg ggctgctgcg gggcctgcaa ggagaactat      240

tgtcttatga tcacgtttgc catctttctg tctcttatca tgttggtgga ggtggccgca      300

gccattgctg gctatgtgtt tagagataag gtgatgtcag agtttaataa caacttccgg      360

cagcagatgg agaattaccc gaaaaacaac cacactgctt cgatcctgga caggatgcag      420

gcagatttta agtgctgtgg ggctgctaac tacacagatt gggagaaaat cccttccatg      480

tcgaagaacc gagtccccga ctcctgctgc attaatgtta ctgtgggctg tgggattaat      540

ttcaacgaga aggcgatcca taaggagggc tgtgtggaga agattggggg ctggctgagg      600

aaaaatgtgc tggtggtagc tgcagcagcc cttggaattg cttttgtcga ggttttggga      660

attgtctttg cctgctgcct cgtgaagagt atcagaagtg gctacgaggt gatg            714


<210>  13
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  14
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  14
ggccagagag cgagcgcgca acggcggcga cggcggcgac cccaccgcgc atcctgccag       60

gcctccggcg cccagcgccc cacgcgcccc cgcgcccccg cgcccccgcg cccctttctt      120

cgcgcccccg cccctcggcc cgccaggccc ccttgccggc cacccgccag gccccgcgcc      180

ggcccgcccg ccgcccagga ccggcccgcg ccccgcaggc cgcccgccgc ccgcgccgcc      240

atgggagtgg agggctgcac caagtgcatc aagtacctgc tcttcgtctt caatttcgtc      300

ttctggctgg ctggaggcgt gatcctgggt gtggccctgt ggctccgcca tgacccgcag      360

accaccaacc tcctgtatct ggagctggga gacaagcccg cgcccaacac cttctatgta      420

ggcatctaca tcctcatcgc tgtgggcgct gtcatgatgt tcgttggctt cctgggctgc      480

tacggggcca tccaggaatc ccagtgcctg ctggggacgt tcttcacctg cctggtcatc      540

ctgtttgcct gtgaggtggc cgccggcatc tggggctttg tcaacaagga ccagatcgcc      600

aaggatgtga agcagttcta tgaccaggcc ctacagcagg ccgtggtgga tgatgacgcc      660

aacaacgcca aggctgtggt gaagaccttc cacgagacgc ttgactgctg tggctccagc      720

acactgactg ctttgaccac ctcagtgctc aagaacaatt tgtgtccctc gggcagcaac      780

atcatcagca acctcttcaa ggaggactgc caccagaaga tcgatgacct cttctccggg      840

aagctgtacc tcatcggcat tgctgccatc gtggtcgctg tgatcatgat cttcgagatg      900

atcctgagca tggtgctgtg ctgtggcatc cggaacagct ccgtgtactg aggccccgca      960

gctctggcca cagggacctc tgcagtgccc cctaagtgac ccggacactt ccgagggggc     1020

catcaccgcc tgtgtatata acgtttccgg tattactctg ctacacgtag cctttttact     1080

tttggggttt tgtttttgtt ctgaactttc ctgttacctt ttcagggctg acgtcacatg     1140

taggtggcgt gtatgagtgg agacgggcct gggtcttggg gactggaggg caggggtcct     1200

tctgccctgg ggtcccaggg tgctctgcct gctcagccag gcctctcctg ggagccactc     1260

gcccagagac tcagcttggc caacttgggg ggctgtgtcc acccagcccg cccgtcctgt     1320

gggctgcaca gctcaccttg ttccctcctg ccccggttcg agagccgagt ctgtgggcac     1380

tctctgcctt catgcacctg tcctttctaa cacgtcgcct tcaactgtaa tcacaacatc     1440

ctgactccgt catttaataa agaaggaaca tcaggcatgc ta                        1482


