               SEQUENCE LISTING

<110> SPLICEBIO S.L.

<120> Split inteins and their uses

<130> 905 992

<140> EPPCT/2021/058016
<141> 2020-03-26

<160> 108

<170> BiSSAP 1.3.6

<210> 1
<211> 1272
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaN-3FT

<400> 1
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Leu Ser 
            1140                1145                1150        
Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly 
        1155                1160                1165            
Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys 
    1170                1175                1180                
Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly 
1185                1190                1195                1200
Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg 
                1205                1210                1215    
Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro 
            1220                1225                1230        
Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly 
        1235                1240                1245            
Leu Pro Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
    1250                1255                1260                
Asp Tyr Lys Asp Asp Asp Asp Lys 
1265                1270        

<210> 2
<211> 1182
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaC-3FT

<400> 2
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg 
        35                  40                  45              
Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys 
    50                  55                  60                  
Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp 
65                  70                  75                  80  
Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met 
                85                  90                  95      
Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile 
            100                 105                 110         
Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg 
        115                 120                 125             
Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu 
    130                 135                 140                 
Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe 
145                 150                 155                 160 
Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly 
                165                 170                 175     
Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly 
            180                 185                 190         
Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser 
        195                 200                 205             
Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro 
    210                 215                 220                 
Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln 
225                 230                 235                 240 
His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser 
                245                 250                 255     
His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe 
            260                 265                 270         
Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro 
        275                 280                 285             
Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe 
    290                 295                 300                 
Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val 
305                 310                 315                 320 
Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp 
                325                 330                 335     
Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser 
            340                 345                 350         
Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln 
        355                 360                 365             
Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr 
    370                 375                 380                 
Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln 
385                 390                 395                 400 
Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn 
                405                 410                 415     
Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser 
            420                 425                 430         
Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser 
        435                 440                 445             
Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val 
    450                 455                 460                 
Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro 
465                 470                 475                 480 
Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu 
                485                 490                 495     
Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His 
            500                 505                 510         
Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala 
        515                 520                 525             
Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile 
    530                 535                 540                 
Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val 
545                 550                 555                 560 
Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser 
                565                 570                 575     
Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg 
            580                 585                 590         
Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr 
        595                 600                 605             
Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val 
    610                 615                 620                 
Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala 
625                 630                 635                 640 
Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu 
                645                 650                 655     
Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe 
            660                 665                 670         
Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe 
        675                 680                 685             
Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu 
    690                 695                 700                 
Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu 
705                 710                 715                 720 
Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala 
                725                 730                 735     
Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His 
            740                 745                 750         
Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala 
        755                 760                 765             
Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln 
    770                 775                 780                 
Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro 
785                 790                 795                 800 
Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile 
                805                 810                 815     
Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys 
            820                 825                 830         
Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly 
        835                 840                 845             
Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly 
    850                 855                 860                 
Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser 
865                 870                 875                 880 
Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu 
                885                 890                 895     
Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu 
            900                 905                 910         
Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly 
        915                 920                 925             
Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser 
    930                 935                 940                 
Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly 
945                 950                 955                 960 
Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro 
                965                 970                 975     
Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala 
            980                 985                 990         
Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg 
        995                 1000                1005            
Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys 
    1010                1015                1020                
Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr 
1025                1030                1035                1040
Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met 
                1045                1050                1055    
Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val 
            1060                1065                1070        
Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg 
        1075                1080                1085            
His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg 
    1090                1095                1100                
Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu 
1105                1110                1115                1120
Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala 
                1125                1130                1135    
Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala 
            1140                1145                1150        
Gly Ala Ser Arg Gln Ala Gln Asp Asp Tyr Lys Asp His Asp Gly Asp 
        1155                1160                1165            
Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    1170                1175                1180        

<210> 3
<211> 1262
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaN-3FT

<400> 3
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
            1140                1145                1150        
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
        1155                1160                1165            
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
    1170                1175                1180                
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
1185                1190                1195                1200
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
                1205                1210                1215    
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
            1220                1225                1230        
Leu Lys Gln Val Asp Gly Leu Pro Asp Tyr Lys Asp His Asp Gly Asp 
        1235                1240                1245            
Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    1250                1255                1260        

<210> 4
<211> 1192
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaCmut-3FT

<400> 4
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe 
        35                  40                  45              
Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln 
    50                  55                  60                  
Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly 
65                  70                  75                  80  
Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln 
                85                  90                  95      
Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His 
            100                 105                 110         
Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe 
        115                 120                 125             
Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe 
    130                 135                 140                 
Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 
145                 150                 155                 160 
Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp 
                165                 170                 175     
Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu 
            180                 185                 190         
Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly 
        195                 200                 205             
Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala 
    210                 215                 220                 
His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln 
225                 230                 235                 240 
Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu 
                245                 250                 255     
Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala 
            260                 265                 270         
Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
        275                 280                 285             
Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro 
    290                 295                 300                 
Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly 
305                 310                 315                 320 
Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly 
                325                 330                 335     
Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys 
            340                 345                 350         
Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr 
        355                 360                 365             
Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser 
    370                 375                 380                 
Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 
385                 390                 395                 400 
Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr 
                405                 410                 415     
Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val 
            420                 425                 430         
Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp 
        435                 440                 445             
Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro 
    450                 455                 460                 
Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu 
465                 470                 475                 480 
Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser 
                485                 490                 495     
Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile 
            500                 505                 510         
Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu 
        515                 520                 525             
Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg 
    530                 535                 540                 
Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu 
545                 550                 555                 560 
Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp 
                565                 570                 575     
Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala 
            580                 585                 590         
Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His 
        595                 600                 605             
Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn 
    610                 615                 620                 
Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 
625                 630                 635                 640 
Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn 
                645                 650                 655     
Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile 
            660                 665                 670         
Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala 
        675                 680                 685             
Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser 
    690                 695                 700                 
Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu 
705                 710                 715                 720 
Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe 
                725                 730                 735     
Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr 
            740                 745                 750         
Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His 
        755                 760                 765             
Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val 
    770                 775                 780                 
Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser 
785                 790                 795                 800 
Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp 
                805                 810                 815     
Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr 
            820                 825                 830         
Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser 
        835                 840                 845             
Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys 
    850                 855                 860                 
Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 
865                 870                 875                 880 
Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala 
                885                 890                 895     
Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly 
            900                 905                 910         
Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu 
        915                 920                 925             
His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile 
    930                 935                 940                 
Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr 
945                 950                 955                 960 
Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu 
                965                 970                 975     
Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp 
            980                 985                 990         
Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn 
        995                 1000                1005            
Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser 
    1010                1015                1020                
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met 
1025                1030                1035                1040
Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser 
                1045                1050                1055    
Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys 
            1060                1065                1070        
Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly 
        1075                1080                1085            
Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln 
    1090                1095                1100                
Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 
1105                1110                1115                1120
Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr 
                1125                1130                1135    
Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser 
            1140                1145                1150        
His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala 
        1155                1160                1165            
Gln Asp Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
    1170                1175                1180                
Asp Tyr Lys Asp Asp Asp Asp Lys 
1185                1190        

<210> 5
<211> 1310
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1188-CfaN-3FT

<400> 5
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
1185                1190                1195                1200
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
                1205                1210                1215    
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
            1220                1225                1230        
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
        1235                1240                1245            
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
    1250                1255                1260                
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
1265                1270                1275                1280
Leu Lys Gln Val Asp Gly Leu Pro Asp Tyr Lys Asp His Asp Gly Asp 
                1285                1290                1295    
Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            1300                1305                1310

<210> 6
<211> 1144
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1188-Cfacmut-3FT

<400> 6
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln 
        35                  40                  45              
Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His 
    50                  55                  60                  
Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe 
65                  70                  75                  80  
Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe 
                85                  90                  95      
Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 
            100                 105                 110         
Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp 
        115                 120                 125             
Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu 
    130                 135                 140                 
Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly 
145                 150                 155                 160 
Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala 
                165                 170                 175     
His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln 
            180                 185                 190         
Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu 
        195                 200                 205             
Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala 
    210                 215                 220                 
Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
225                 230                 235                 240 
Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro 
                245                 250                 255     
Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly 
            260                 265                 270         
Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly 
        275                 280                 285             
Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys 
    290                 295                 300                 
Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr 
305                 310                 315                 320 
Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser 
                325                 330                 335     
Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 
            340                 345                 350         
Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr 
        355                 360                 365             
Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val 
    370                 375                 380                 
Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp 
385                 390                 395                 400 
Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro 
                405                 410                 415     
Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu 
            420                 425                 430         
Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser 
        435                 440                 445             
Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile 
    450                 455                 460                 
Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu 
465                 470                 475                 480 
Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg 
                485                 490                 495     
Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu 
            500                 505                 510         
Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp 
        515                 520                 525             
Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala 
    530                 535                 540                 
Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His 
545                 550                 555                 560 
Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn 
                565                 570                 575     
Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 
            580                 585                 590         
Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn 
        595                 600                 605             
Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile 
    610                 615                 620                 
Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala 
625                 630                 635                 640 
Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser 
                645                 650                 655     
Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu 
            660                 665                 670         
Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe 
        675                 680                 685             
Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr 
    690                 695                 700                 
Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His 
705                 710                 715                 720 
Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val 
                725                 730                 735     
Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser 
            740                 745                 750         
Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp 
        755                 760                 765             
Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr 
    770                 775                 780                 
Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser 
785                 790                 795                 800 
Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys 
                805                 810                 815     
Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 
            820                 825                 830         
Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala 
        835                 840                 845             
Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly 
    850                 855                 860                 
Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu 
865                 870                 875                 880 
His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile 
                885                 890                 895     
Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr 
            900                 905                 910         
Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu 
        915                 920                 925             
Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp 
    930                 935                 940                 
Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn 
945                 950                 955                 960 
Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser 
                965                 970                 975     
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met 
            980                 985                 990         
Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser 
        995                 1000                1005            
Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys 
    1010                1015                1020                
Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly 
1025                1030                1035                1040
Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln 
                1045                1050                1055    
Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 
            1060                1065                1070        
Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr 
        1075                1080                1085            
Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser 
    1090                1095                1100                
His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala 
1105                1110                1115                1120
Gln Asp Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
                1125                1130                1135    
Asp Tyr Lys Asp Asp Asp Asp Lys 
            1140                

<210> 7
<211> 2295
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-3FT

<400> 7
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val 
1185                1190                1195                1200
Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val 
                1205                1210                1215    
Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu 
            1220                1225                1230        
Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg 
        1235                1240                1245            
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile 
    1250                1255                1260                
Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser 
1265                1270                1275                1280
Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn 
                1285                1290                1295    
Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln 
            1300                1305                1310        
Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His 
        1315                1320                1325            
Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu 
    1330                1335                1340                
Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val 
1345                1350                1355                1360
Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln 
                1365                1370                1375    
Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile 
            1380                1385                1390        
Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp 
        1395                1400                1405            
Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser 
    1410                1415                1420                
Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe 
1425                1430                1435                1440
Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly 
                1445                1450                1455    
Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln 
            1460                1465                1470        
Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys 
        1475                1480                1485            
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu 
    1490                1495                1500                
Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu 
1505                1510                1515                1520
Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys 
                1525                1530                1535    
Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val 
            1540                1545                1550        
Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val 
        1555                1560                1565            
Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly 
    1570                1575                1580                
Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys 
1585                1590                1595                1600
Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys 
                1605                1610                1615    
Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn 
            1620                1625                1630        
Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser 
        1635                1640                1645            
Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr 
    1650                1655                1660                
Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala 
1665                1670                1675                1680
Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser 
                1685                1690                1695    
Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu 
            1700                1705                1710        
Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe 
        1715                1720                1725            
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly 
    1730                1735                1740                
Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu 
1745                1750                1755                1760
Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro 
                1765                1770                1775    
Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr 
            1780                1785                1790        
Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala 
        1795                1800                1805            
Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg 
    1810                1815                1820                
Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys 
1825                1830                1835                1840
Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp 
                1845                1850                1855    
Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp 
            1860                1865                1870        
Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val 
        1875                1880                1885            
Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln 
    1890                1895                1900                
Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp 
1905                1910                1915                1920
Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp 
                1925                1930                1935    
Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser 
            1940                1945                1950        
Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe 
        1955                1960                1965            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met 
    1970                1975                1980                
Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly 
1985                1990                1995                2000
Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr 
                2005                2010                2015    
Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His 
            2020                2025                2030        
Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu 
        2035                2040                2045            
Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala 
    2050                2055                2060                
Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser 
2065                2070                2075                2080
Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu 
                2085                2090                2095    
Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val 
            2100                2105                2110        
Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His 
        2115                2120                2125            
Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val 
    2130                2135                2140                
Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys 
2145                2150                2155                2160
Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp 
                2165                2170                2175    
Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn 
            2180                2185                2190        
Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe 
        2195                2200                2205            
Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser 
    2210                2215                2220                
His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr 
2225                2230                2235                2240
Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His 
                2245                2250                2255    
Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln 
            2260                2265                2270        
Asp Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
        2275                2280                2285            
Tyr Lys Asp Asp Asp Asp Lys 
    2290                2295

<210> 8
<211> 1273
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-NpuN-3FT

<400> 8
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Leu Ser 
            1140                1145                1150        
Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly 
        1155                1160                1165            
Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn 
    1170                1175                1180                
Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly 
1185                1190                1195                1200
Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg 
                1205                1210                1215    
Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro 
            1220                1225                1230        
Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn 
        1235                1240                1245            
Leu Pro Asn Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
    1250                1255                1260                
Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
1265                1270            

<210> 9
<211> 1182
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-NpuC-3FT

<400> 9
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          
Ile Ala Ser Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg 
        35                  40                  45              
Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys 
    50                  55                  60                  
Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp 
65                  70                  75                  80  
Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met 
                85                  90                  95      
Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile 
            100                 105                 110         
Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg 
        115                 120                 125             
Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu 
    130                 135                 140                 
Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe 
145                 150                 155                 160 
Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly 
                165                 170                 175     
Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly 
            180                 185                 190         
Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser 
        195                 200                 205             
Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro 
    210                 215                 220                 
Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln 
225                 230                 235                 240 
His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser 
                245                 250                 255     
His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe 
            260                 265                 270         
Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro 
        275                 280                 285             
Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe 
    290                 295                 300                 
Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val 
305                 310                 315                 320 
Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp 
                325                 330                 335     
Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser 
            340                 345                 350         
Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln 
        355                 360                 365             
Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr 
    370                 375                 380                 
Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln 
385                 390                 395                 400 
Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn 
                405                 410                 415     
Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser 
            420                 425                 430         
Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser 
        435                 440                 445             
Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val 
    450                 455                 460                 
Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro 
465                 470                 475                 480 
Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu 
                485                 490                 495     
Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His 
            500                 505                 510         
Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala 
        515                 520                 525             
Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile 
    530                 535                 540                 
Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val 
545                 550                 555                 560 
Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser 
                565                 570                 575     
Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg 
            580                 585                 590         
Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr 
        595                 600                 605             
Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val 
    610                 615                 620                 
Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala 
625                 630                 635                 640 
Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu 
                645                 650                 655     
Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe 
            660                 665                 670         
Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe 
        675                 680                 685             
Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu 
    690                 695                 700                 
Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu 
705                 710                 715                 720 
Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala 
                725                 730                 735     
Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His 
            740                 745                 750         
Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala 
        755                 760                 765             
Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln 
    770                 775                 780                 
Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro 
785                 790                 795                 800 
Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile 
                805                 810                 815     
Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys 
            820                 825                 830         
Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly 
        835                 840                 845             
Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly 
    850                 855                 860                 
Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser 
865                 870                 875                 880 
Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu 
                885                 890                 895     
Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu 
            900                 905                 910         
Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly 
        915                 920                 925             
Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser 
    930                 935                 940                 
Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly 
945                 950                 955                 960 
Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro 
                965                 970                 975     
Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala 
            980                 985                 990         
Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg 
        995                 1000                1005            
Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys 
    1010                1015                1020                
Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr 
1025                1030                1035                1040
Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met 
                1045                1050                1055    
Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val 
            1060                1065                1070        
Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg 
        1075                1080                1085            
His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg 
    1090                1095                1100                
Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu 
1105                1110                1115                1120
Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala 
                1125                1130                1135    
Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala 
            1140                1145                1150        
Gly Ala Ser Arg Gln Ala Gln Asp Asp Tyr Lys Asp His Asp Gly Asp 
        1155                1160                1165            
Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    1170                1175                1180        

<210> 10
<211> 1263
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-NpuN-3FT

<400> 10
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 
            1140                1145                1150        
Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 
        1155                1160                1165            
Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 
    1170                1175                1180                
Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
1185                1190                1195                1200
Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 
                1205                1210                1215    
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 
            1220                1225                1230        
Leu Met Arg Val Asp Asn Leu Pro Asn Asp Tyr Lys Asp His Asp Gly 
        1235                1240                1245            
Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    1250                1255                1260            

<210> 11
<211> 1192
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-NpuC-3FT

<400> 11
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          
Ile Ala Ser Asn Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe 
        35                  40                  45              
Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln 
    50                  55                  60                  
Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly 
65                  70                  75                  80  
Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln 
                85                  90                  95      
Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His 
            100                 105                 110         
Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe 
        115                 120                 125             
Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe 
    130                 135                 140                 
Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 
145                 150                 155                 160 
Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp 
                165                 170                 175     
Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu 
            180                 185                 190         
Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly 
        195                 200                 205             
Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala 
    210                 215                 220                 
His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln 
225                 230                 235                 240 
Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu 
                245                 250                 255     
Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala 
            260                 265                 270         
Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
        275                 280                 285             
Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro 
    290                 295                 300                 
Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly 
305                 310                 315                 320 
Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly 
                325                 330                 335     
Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys 
            340                 345                 350         
Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr 
        355                 360                 365             
Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser 
    370                 375                 380                 
Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 
385                 390                 395                 400 
Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr 
                405                 410                 415     
Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val 
            420                 425                 430         
Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp 
        435                 440                 445             
Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro 
    450                 455                 460                 
Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu 
465                 470                 475                 480 
Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser 
                485                 490                 495     
Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile 
            500                 505                 510         
Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu 
        515                 520                 525             
Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg 
    530                 535                 540                 
Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu 
545                 550                 555                 560 
Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp 
                565                 570                 575     
Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala 
            580                 585                 590         
Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His 
        595                 600                 605             
Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn 
    610                 615                 620                 
Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 
625                 630                 635                 640 
Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn 
                645                 650                 655     
Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile 
            660                 665                 670         
Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala 
        675                 680                 685             
Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser 
    690                 695                 700                 
Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu 
705                 710                 715                 720 
Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe 
                725                 730                 735     
Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr 
            740                 745                 750         
Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His 
        755                 760                 765             
Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val 
    770                 775                 780                 
Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser 
785                 790                 795                 800 
Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp 
                805                 810                 815     
Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr 
            820                 825                 830         
Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser 
        835                 840                 845             
Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys 
    850                 855                 860                 
Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 
865                 870                 875                 880 
Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala 
                885                 890                 895     
Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly 
            900                 905                 910         
Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu 
        915                 920                 925             
His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile 
    930                 935                 940                 
Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr 
945                 950                 955                 960 
Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu 
                965                 970                 975     
Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp 
            980                 985                 990         
Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn 
        995                 1000                1005            
Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser 
    1010                1015                1020                
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met 
1025                1030                1035                1040
Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser 
                1045                1050                1055    
Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys 
            1060                1065                1070        
Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly 
        1075                1080                1085            
Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln 
    1090                1095                1100                
Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 
1105                1110                1115                1120
Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr 
                1125                1130                1135    
Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser 
            1140                1145                1150        
His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala 
        1155                1160                1165            
Gln Asp Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
    1170                1175                1180                
Asp Tyr Lys Asp Asp Asp Asp Lys 
1185                1190        

<210> 12
<211> 1311
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1188-NpuN-3FT

<400> 12
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 
1185                1190                1195                1200
Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 
                1205                1210                1215    
Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 
            1220                1225                1230        
Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
        1235                1240                1245            
Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 
    1250                1255                1260                
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 
1265                1270                1275                1280
Leu Met Arg Val Asp Asn Leu Pro Asn Asp Tyr Lys Asp His Asp Gly 
                1285                1290                1295    
Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            1300                1305                1310    

<210> 13
<211> 1144
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1188-NpuC-3FT

<400> 13
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          
Ile Ala Ser Asn Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln 
        35                  40                  45              
Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His 
    50                  55                  60                  
Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe 
65                  70                  75                  80  
Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe 
                85                  90                  95      
Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 
            100                 105                 110         
Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp 
        115                 120                 125             
Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu 
    130                 135                 140                 
Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly 
145                 150                 155                 160 
Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala 
                165                 170                 175     
His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln 
            180                 185                 190         
Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu 
        195                 200                 205             
Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala 
    210                 215                 220                 
Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
225                 230                 235                 240 
Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro 
                245                 250                 255     
Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly 
            260                 265                 270         
Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly 
        275                 280                 285             
Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys 
    290                 295                 300                 
Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr 
305                 310                 315                 320 
Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser 
                325                 330                 335     
Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 
            340                 345                 350         
Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr 
        355                 360                 365             
Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val 
    370                 375                 380                 
Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp 
385                 390                 395                 400 
Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro 
                405                 410                 415     
Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu 
            420                 425                 430         
Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser 
        435                 440                 445             
Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile 
    450                 455                 460                 
Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu 
465                 470                 475                 480 
Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg 
                485                 490                 495     
Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu 
            500                 505                 510         
Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp 
        515                 520                 525             
Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala 
    530                 535                 540                 
Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His 
545                 550                 555                 560 
Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn 
                565                 570                 575     
Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 
            580                 585                 590         
Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn 
        595                 600                 605             
Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile 
    610                 615                 620                 
Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala 
625                 630                 635                 640 
Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser 
                645                 650                 655     
Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu 
            660                 665                 670         
Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe 
        675                 680                 685             
Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr 
    690                 695                 700                 
Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His 
705                 710                 715                 720 
Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val 
                725                 730                 735     
Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser 
            740                 745                 750         
Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp 
        755                 760                 765             
Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr 
    770                 775                 780                 
Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser 
785                 790                 795                 800 
Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys 
                805                 810                 815     
Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 
            820                 825                 830         
Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala 
        835                 840                 845             
Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly 
    850                 855                 860                 
Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu 
865                 870                 875                 880 
His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile 
                885                 890                 895     
Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr 
            900                 905                 910         
Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu 
        915                 920                 925             
Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp 
    930                 935                 940                 
Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn 
945                 950                 955                 960 
Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser 
                965                 970                 975     
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met 
            980                 985                 990         
Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser 
        995                 1000                1005            
Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys 
    1010                1015                1020                
Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly 
1025                1030                1035                1040
Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln 
                1045                1050                1055    
Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 
            1060                1065                1070        
Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr 
        1075                1080                1085            
Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser 
    1090                1095                1100                
His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala 
1105                1110                1115                1120
Gln Asp Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
                1125                1130                1135    
Asp Tyr Lys Asp Asp Asp Asp Lys 
            1140                

<210> 14
<211> 179
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71- CfaN

<400> 14
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr 
65                  70                  75                  80  
Val Glu Tyr Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile 
                85                  90                  95      
Glu Cys Thr Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln 
            100                 105                 110         
Pro Ile Ala Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr 
        115                 120                 125             
Cys Leu Glu Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe 
    130                 135                 140                 
Met Thr Thr Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg 
145                 150                 155                 160 
Gly Leu Asp Leu Lys Gln Val Asp Gly Leu Pro Gly His His His His 
                165                 170                 175     
His His Gly 
            

<210> 15
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71- CfaC

<400> 15
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
        35                  40                  45              
Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
    50                  55                  60                  
Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
65                  70                  75                  80  
Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
                85                  90                  95      
Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
            100                 105                 110         
Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
        115                 120                 125             
Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
    130                 135                 140                 
Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
145                 150                 155                 160 
Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                165                 170                 175     
Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
            180                 185                 190         
Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly His His 
        195                 200                 205             
His His His His Gly 
    210             

<210> 16
<211> 247
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP

<400> 16
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 
His His His His His His Gly 
                245         

<210> 17
<211> 180
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71- NpuN

<400> 17
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr 
65                  70                  75                  80  
Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile 
                85                  90                  95      
Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln 
            100                 105                 110         
Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr 
        115                 120                 125             
Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe 
    130                 135                 140                 
Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg 
145                 150                 155                 160 
Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn Gly His His His 
                165                 170                 175     
His His His Gly 
            180 

<210> 18
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71- NpuC

<400> 18
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          
Ile Ala Ser Asn Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
        35                  40                  45              
Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
    50                  55                  60                  
Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
65                  70                  75                  80  
Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
                85                  90                  95      
Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
            100                 105                 110         
Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
        115                 120                 125             
Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
    130                 135                 140                 
Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
145                 150                 155                 160 
Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                165                 170                 175     
Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
            180                 185                 190         
Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly His His 
        195                 200                 205             
His His His His Gly 
    210             

<210> 19
<211> 1371
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaN-3FT-SopE

<400> 19
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Leu Ser 
            1140                1145                1150        
Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly 
        1155                1160                1165            
Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys 
    1170                1175                1180                
Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly 
1185                1190                1195                1200
Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg 
                1205                1210                1215    
Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro 
            1220                1225                1230        
Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly 
        1235                1240                1245            
Leu Pro Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
    1250                1255                1260                
Asp Tyr Lys Asp Asp Asp Asp Lys Thr Lys Ile Thr Leu Ser Pro Gln 
1265                1270                1275                1280
Asn Phe Arg Ile Gln Lys Gln Glu Thr Thr Leu Leu Lys Glu Lys Ser 
                1285                1290                1295    
Thr Glu Lys Asn Ser Leu Ala Lys Ser Ile Leu Ala Val Lys Asn His 
            1300                1305                1310        
Phe Ile Glu Leu Arg Ser Lys Leu Ser Glu Arg Phe Ile Ser His Lys 
        1315                1320                1325            
Asn Thr Glu Ser Ser Ala Thr His Phe His Arg Gly Ser Ala Ser Glu 
    1330                1335                1340                
Gly Arg Ala Val Leu Thr Asn Lys Val Val Lys Asp Phe Met Leu Gln 
1345                1350                1355                1360
Thr Leu Asn Asp Ile Asp Ile Arg Gly Ser Ala 
                1365                1370    

<210> 20
<211> 1281
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaC-3FT-SopE

<400> 20
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  
Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      
Arg Gly Ser Ala Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln 
            100                 105                 110         
Asn Val Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys 
        115                 120                 125             
Asn Gly Leu Val Ala Ser Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr 
    130                 135                 140                 
Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu 
145                 150                 155                 160 
Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala 
                165                 170                 175     
His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn 
            180                 185                 190         
Glu Leu Met Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val 
        195                 200                 205             
Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe 
    210                 215                 220                 
Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu 
225                 230                 235                 240 
Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu 
                245                 250                 255     
Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe 
            260                 265                 270         
Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro 
        275                 280                 285             
Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn 
    290                 295                 300                 
Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro 
305                 310                 315                 320 
Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu 
                325                 330                 335     
Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr 
            340                 345                 350         
Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr 
        355                 360                 365             
Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly 
    370                 375                 380                 
Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr 
385                 390                 395                 400 
Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu 
                405                 410                 415     
Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys 
            420                 425                 430         
Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys 
        435                 440                 445             
Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys 
    450                 455                 460                 
Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu 
465                 470                 475                 480 
Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro 
                485                 490                 495     
Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr 
            500                 505                 510         
Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile 
        515                 520                 525             
Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly 
    530                 535                 540                 
Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu 
545                 550                 555                 560 
Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser 
                565                 570                 575     
Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu 
            580                 585                 590         
Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys 
        595                 600                 605             
Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile 
    610                 615                 620                 
Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile 
625                 630                 635                 640 
Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu 
                645                 650                 655     
Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val 
            660                 665                 670         
Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile 
        675                 680                 685             
Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val 
    690                 695                 700                 
Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn 
705                 710                 715                 720 
Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln 
                725                 730                 735     
Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu 
            740                 745                 750         
Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser 
        755                 760                 765             
Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala 
    770                 775                 780                 
Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu 
785                 790                 795                 800 
Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg 
                805                 810                 815     
Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile 
            820                 825                 830         
Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly 
        835                 840                 845             
Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn 
    850                 855                 860                 
Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu 
865                 870                 875                 880 
Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr 
                885                 890                 895     
Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln 
            900                 905                 910         
Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu 
        915                 920                 925             
Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu 
    930                 935                 940                 
Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn 
945                 950                 955                 960 
Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr 
                965                 970                 975     
Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn 
            980                 985                 990         
Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala 
        995                 1000                1005            
Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg 
    1010                1015                1020                
Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser 
1025                1030                1035                1040
Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr 
                1045                1050                1055    
Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile 
            1060                1065                1070        
Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp 
        1075                1080                1085            
Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg 
    1090                1095                1100                
Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu 
1105                1110                1115                1120
Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys 
                1125                1130                1135    
Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile 
            1140                1145                1150        
Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu 
        1155                1160                1165            
Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln 
    1170                1175                1180                
Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser 
1185                1190                1195                1200
Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu 
                1205                1210                1215    
Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val 
            1220                1225                1230        
Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro 
        1235                1240                1245            
Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp Asp Tyr Lys Asp His 
    1250                1255                1260                
Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
1265                1270                1275                1280
Lys 
    

<210> 21
<211> 1361
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaN-3FT-SopE

<400> 21
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
            1140                1145                1150        
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
        1155                1160                1165            
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
    1170                1175                1180                
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
1185                1190                1195                1200
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
                1205                1210                1215    
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
            1220                1225                1230        
Leu Lys Gln Val Asp Gly Leu Pro Asp Tyr Lys Asp His Asp Gly Asp 
        1235                1240                1245            
Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr Lys 
    1250                1255                1260                
Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln Glu Thr Thr 
1265                1270                1275                1280
Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala Lys Ser Ile 
                1285                1290                1295    
Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys Leu Ser Glu 
            1300                1305                1310        
Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr His Phe His 
        1315                1320                1325            
Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn Lys Val Val 
    1330                1335                1340                
Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile Arg Gly Ser 
1345                1350                1355                1360
Ala 
    

<210> 22
<211> 1291
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaC-3FT-SopE

<400> 22
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  
Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      
Arg Gly Ser Ala Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln 
            100                 105                 110         
Asn Val Tyr Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys 
        115                 120                 125             
Asn Gly Leu Val Ala Ser Asn Cys Ser Gly Thr Pro Leu Phe Leu Lys 
    130                 135                 140                 
Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys 
145                 150                 155                 160 
Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser 
                165                 170                 175     
Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr 
            180                 185                 190         
Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val 
        195                 200                 205             
Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu 
    210                 215                 220                 
Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala 
225                 230                 235                 240 
Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser 
                245                 250                 255     
Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val 
            260                 265                 270         
Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln 
        275                 280                 285             
Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu 
    290                 295                 300                 
Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala 
305                 310                 315                 320 
Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro 
                325                 330                 335     
Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln 
            340                 345                 350         
Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp 
        355                 360                 365             
Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu 
    370                 375                 380                 
Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr 
385                 390                 395                 400 
Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp 
                405                 410                 415     
Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn 
            420                 425                 430         
Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu 
        435                 440                 445             
Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro 
    450                 455                 460                 
Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro 
465                 470                 475                 480 
Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro 
                485                 490                 495     
Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln 
            500                 505                 510         
Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp 
        515                 520                 525             
Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser 
    530                 535                 540                 
Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly 
545                 550                 555                 560 
Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu 
                565                 570                 575     
Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg 
            580                 585                 590         
Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu 
        595                 600                 605             
Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val 
    610                 615                 620                 
Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro 
625                 630                 635                 640 
Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro 
                645                 650                 655     
Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr 
            660                 665                 670         
Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe 
        675                 680                 685             
Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys 
    690                 695                 700                 
Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp 
705                 710                 715                 720 
Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly 
                725                 730                 735     
Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser 
            740                 745                 750         
Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp 
        755                 760                 765             
Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro 
    770                 775                 780                 
Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile 
785                 790                 795                 800 
Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg 
                805                 810                 815     
Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe 
            820                 825                 830         
Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln 
        835                 840                 845             
Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn 
    850                 855                 860                 
Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val 
865                 870                 875                 880 
Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe 
                885                 890                 895     
Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp 
            900                 905                 910         
Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly 
        915                 920                 925             
Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro 
    930                 935                 940                 
Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro 
945                 950                 955                 960 
Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr 
                965                 970                 975     
Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala 
            980                 985                 990         
Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln 
        995                 1000                1005            
Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr 
    1010                1015                1020                
Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala 
1025                1030                1035                1040
Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu 
                1045                1050                1055    
Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys 
            1060                1065                1070        
Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val 
        1075                1080                1085            
Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met 
    1090                1095                1100                
Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val 
1105                1110                1115                1120
Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu 
                1125                1130                1135    
Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His 
            1140                1145                1150        
Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys 
        1155                1160                1165            
Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe 
    1170                1175                1180                
Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn 
1185                1190                1195                1200
Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln 
                1205                1210                1215    
Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val 
            1220                1225                1230        
Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln 
        1235                1240                1245            
Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser 
    1250                1255                1260                
Arg Gln Ala Gln Asp Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
1265                1270                1275                1280
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
                1285                1290    

<210> 23
<211> 278
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71-CfaN-SopE

<400> 23
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr 
65                  70                  75                  80  
Val Glu Tyr Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile 
                85                  90                  95      
Glu Cys Thr Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln 
            100                 105                 110         
Pro Ile Ala Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr 
        115                 120                 125             
Cys Leu Glu Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe 
    130                 135                 140                 
Met Thr Thr Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg 
145                 150                 155                 160 
Gly Leu Asp Leu Lys Gln Val Asp Gly Leu Pro Gly His His His His 
                165                 170                 175     
His His Gly Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln 
            180                 185                 190         
Lys Gln Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser 
        195                 200                 205             
Leu Ala Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg 
    210                 215                 220                 
Ser Lys Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser 
225                 230                 235                 240 
Ala Thr His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu 
                245                 250                 255     
Thr Asn Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile 
            260                 265                 270         
Asp Ile Arg Gly Ser Ala 
        275             

<210> 24
<211> 312
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71-CfaC-SopE

<400> 24
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  
Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      
Arg Gly Ser Ala Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln 
            100                 105                 110         
Asn Val Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys 
        115                 120                 125             
Asn Gly Leu Val Ala Ser Asn Cys Phe Ser Arg Tyr Pro Asp His Met 
    130                 135                 140                 
Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
145                 150                 155                 160 
Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                165                 170                 175     
Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            180                 185                 190         
Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
        195                 200                 205             
Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
    210                 215                 220                 
Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
225                 230                 235                 240 
Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
                245                 250                 255     
Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
            260                 265                 270         
Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
        275                 280                 285             
Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
    290                 295                 300                 
Gly His His His His His His Gly 
305                 310         

<210> 25
<211> 192
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71-CfaN-DD1

<400> 25
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr 
65                  70                  75                  80  
Val Glu Tyr Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile 
                85                  90                  95      
Glu Cys Thr Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln 
            100                 105                 110         
Pro Ile Ala Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr 
        115                 120                 125             
Cys Leu Glu Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe 
    130                 135                 140                 
Met Thr Thr Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg 
145                 150                 155                 160 
Gly Leu Asp Leu Lys Gln Val Asp Gly Leu Pro Gly His His His His 
                165                 170                 175     
His His Gly Arg Ile Ser Phe Gly Ser Pro Pro Pro Met Ala Gly Gly 
            180                 185                 190         



<210> 26
<211> 226
<212> PRT
<213> Artificial Sequence


<220> 
<223> EGFP-71-CfaC-DD1

<400> 26
Met Arg Ile Ser Phe Gly Ser Pro Pro Pro Met Ala Gly Gly Val Lys 
1               5                   10                  15      
Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp Ile Gly 
            20                  25                  30          
Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu Val Ala Ser 
        35                  40                  45              
Asn Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
    50                  55                  60                  
Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
65                  70                  75                  80  
Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
                85                  90                  95      
Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
            100                 105                 110         
Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
        115                 120                 125             
Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
    130                 135                 140                 
Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
145                 150                 155                 160 
His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
                165                 170                 175     
Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
            180                 185                 190         
Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
        195                 200                 205             
Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly His His His His His 
    210                 215                 220                 
His Gly 
225     

<210> 27
<211> 101
<212> PRT
<213> Artificial Sequence


<220> 
<223> CfaN

<400> 27
Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      
Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          
Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              
Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  
Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  
Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      
Val Asp Gly Leu Pro 
            100     

<210> 28
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> CfaC

<400> 28
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn 
        35      

<210> 29
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> CfaCmut

<400> 29
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn 
        35      

<210> 30
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> CatN

<400> 30
Cys Leu Ser Gly Asp Thr Met Ile Glu Ile Leu Asp Asp Asp Gly Ile 
1               5                   10                  15      
Ile Gln Lys Ile Ser Met Glu Asp Leu Tyr Gln Arg Leu Ala 
            20                  25                  30  

<210> 31
<211> 104
<212> PRT
<213> Artificial Sequence


<220> 
<223> CatC

<400> 31
Met Phe Lys Leu Asn Thr Lys Asn Ile Lys Val Leu Thr Pro Ser Gly 
1               5                   10                  15      
Phe Lys Ser Phe Ser Gly Ile Gln Lys Val Tyr Lys Pro Phe Tyr His 
            20                  25                  30          
His Ile Ile Phe Asp Asp Gly Ser Glu Ile Lys Cys Ser Asp Asn His 
        35                  40                  45              
Ser Phe Gly Lys Asp Lys Ile Lys Ala Ser Thr Ile Lys Val Gly Asp 
    50                  55                  60                  
Tyr Leu Gln Gly Lys Lys Val Leu Tyr Asn Glu Ile Val Glu Glu Gly 
65                  70                  75                  80  
Ile Tyr Leu Tyr Asp Leu Leu Asn Val Gly Glu Asp Asn Leu Tyr Tyr 
                85                  90                  95      
Thr Asn Gly Ile Val Ser His Asn 
            100                 

<210> 32
<211> 102
<212> PRT
<213> Artificial Sequence


<220> 
<223> NpuN

<400> 32
Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      
Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          
Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              
Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  
Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  
Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      
Val Asp Asn Leu Pro Asn 
            100         

<210> 33
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> NpuC

<400> 33
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          
Ile Ala Ser Asn 
        35      

<210> 34
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> M3

<400> 34
Lys Ser Val Thr Leu Glu Ser Arg Ser Pro Lys Phe Leu Asn Trp Phe 
1               5                   10                  15      
Ser Val Phe Ser Leu Phe Lys Val Ile Thr Thr Gly 
            20                  25              

<210> 35
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> M4

<400> 35
Tyr Met Ser Ile Leu Arg Cys Ala Ser Gly Lys Ile Ser Ile Ala Ala 
1               5                   10                  15      
Pro Pro Tyr Ile Phe 
            20      

<210> 36
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> NpuCmut

<400> 36
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          
Ile Ala Ser Asn 
        35      

<210> 37
<211> 34
<212> PRT
<213> Artificial Sequence


<220> 
<223> M5

<400> 37
Ala Gly Glu Ser Phe Asn Phe Met Val Lys Leu Leu Tyr Lys His Pro 
1               5                   10                  15      
Ile Leu Pro Cys Leu Lys Thr Leu Leu Ser Ile Arg Ser Ser Cys Ser 
            20                  25                  30          
Pro Arg 
        

<210> 38
<211> 88
<212> PRT
<213> Artificial Sequence


<220> 
<223> GP41N

<400> 38
Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly Met Lys Glu 
1               5                   10                  15      
Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn Thr Gly Tyr 
            20                  25                  30          
Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys Ser Tyr Lys 
        35                  40                  45              
Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu His Leu 
    50                  55                  60                  
Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly Leu Lys Glu 
65                  70                  75                  80  
Gly Met Cys Leu Tyr Val Lys Glu 
                85              

<210> 39
<211> 102
<212> PRT
<213> Artificial Sequence


<220> 
<223> ConN

<400> 39
Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Ala Val 
1               5                   10                  15      
Pro Ile Gly Lys Ile Val Glu Glu Asn Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          
Val Asp Glu Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              
Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  
Thr Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Glu Asp Gly Glu 
65                  70                  75                  80  
Met Leu Pro Ile Asp Glu Ile Phe Glu Gln Gly Leu Asp Leu Lys Gln 
                85                  90                  95      
Val Lys Gly Leu Pro Asp 
            100         

<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> CL1

<400> 40
Ala Cys Lys Asn Trp Phe Ser Ser Leu Ser His Phe Val Ile His Leu 
1               5                   10                  15      



<210> 41
<211> 62
<212> PRT
<213> Artificial Sequence


<220> 
<223> Deg1

<400> 41
Met Asn Lys Ile Pro Ile Lys Asp Leu Leu Asn Pro Gln Ile Thr Asp 
1               5                   10                  15      
Glu Phe Lys Ser Ser Ile Leu Asp Ile Asn Lys Lys Leu Phe Ser Ile 
            20                  25                  30          
Cys Cys Asn Leu Pro Lys Leu Pro Glu Ser Val Thr Thr Glu Glu Glu 
        35                  40                  45              
Val Glu Leu Arg Asp Ile Leu Gly Phe Leu Ser Arg Ala Asn 
    50                  55                  60          

<210> 42
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> PEST

<400> 42
Arg Ser Ser Ser Pro Ser Asp Ser Asp Thr Ser Gly Phe Ser Ser Gly 
1               5                   10                  15      
Ser Asp His Leu Ser Asp Leu Ile Ser Ser Leu Arg Ile Ser 
            20                  25                  30  

<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD1

<220> 
<221> VARIANT
<222> 12
<223> X= any aminoacid, preferably Gly

<400> 43
Arg Ile Ser Phe Gly Ser Pro Pro Pro Met Ala Xaa Gly 
1               5                   10              

<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD2

<220> 
<221> VARIANT
<222> 8
<223> X= any aminoacid, preferably Gly

<400> 44
Gly Ser Pro Pro Pro Met Ala Xaa Gly 
1               5                   

<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD3

<400> 45
Thr Asn Gly Ile Leu Lys Leu Gly Cys Gln Gly 
1               5                   10      

<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> M1

<400> 46
Cys Ser Glu Ile Ile Pro Met Ser Arg Ser Thr Pro Ile Ser Thr Met 
1               5                   10                  15      
Gly 
    

<210> 47
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> M2

<400> 47
Val Ser Phe Ala Phe Asn Leu Asn Ser Leu Ile Val Gly Ile Leu Arg 
1               5                   10                  15      
Phe His Trp 
            

<210> 48
<211> 100
<212> PRT
<213> Artificial Sequence


<220> 
<223> SopE

<400> 48
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  
Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      
Arg Gly Ser Ala 
            100 

<210> 49
<211> 78
<212> PRT
<213> Artificial Sequence


<220> 
<223> SopE-1-78

<400> 49
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu 
65                  70                  75              

<210> 50
<211> 63
<212> PRT
<213> Artificial Sequence


<220> 
<223> SopE-15-78

<400> 50
Gln Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu 
1               5                   10                  15      
Ala Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser 
            20                  25                  30          
Lys Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala 
        35                  40                  45              
Thr His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu 
    50                  55                  60              

<210> 51
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> SopE-15-50

<400> 51
Gln Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu 
1               5                   10                  15      
Ala Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser 
            20                  25                  30          
Lys Leu Ser 
        35  

<210> 52
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> L2

<400> 52
Ser Leu Ile Ser Leu Pro Leu Pro Thr Arg Val Lys Phe Ser Ser Leu 
1               5                   10                  15      
Leu Leu Ile Arg Ile Met Lys Ile Ile Thr Met Thr Phe Pro Lys Lys 
            20                  25                  30          
Leu Arg Ser 
        35  

<210> 53
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> L6

<400> 53
Phe Tyr Tyr Pro Ile Trp Phe Ala Arg Val Leu Leu Val His Tyr Gln 
1               5                   10                  15      



<210> 54
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<223> L9

<400> 54
Ser Asn Pro Phe Ser Ser Leu Phe Gly Ala Ser Leu Leu Ile Asp Ser 
1               5                   10                  15      
Val Ser Leu Lys Ser Asn Trp Asp Thr Ser Ser Ser Ser Cys Leu Ile 
            20                  25                  30          
Ser Phe Phe Ser Ser Val Met Phe Ser Ser Thr Thr Arg Ser 
        35                  40                  45      

<210> 55
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> L10

<400> 55
Cys Arg Gln Arg Phe Ser Cys His Leu Thr Ala Ser Tyr Pro Gln Ser 
1               5                   10                  15      
Thr Val Thr Pro Phe Leu Ala Phe Leu Arg Arg Asp Phe Phe Phe Leu 
            20                  25                  30          
Arg His Asn Ser Ser Ala Asp 
        35                  

<210> 56
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<223> L11

<400> 56
Gly Ala Pro His Val Val Leu Phe Asp Phe Glu Leu Arg Ile Thr Asn 
1               5                   10                  15      
Pro Leu Ser His Ile Gln Ser Val Ser Leu Gln Ile Thr Leu Ile Phe 
            20                  25                  30          
Cys Ser Leu Pro Ser Leu Ile Leu Ser Lys Phe Leu Gln Val 
        35                  40                  45      

<210> 57
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> L12

<400> 57
Asn Thr Pro Leu Phe Ser Lys Ser Phe Ser Thr Thr Cys Gly Val Ala 
1               5                   10                  15      
Lys Lys Thr Leu Leu Leu Ala Gln Ile Ser Ser Leu Phe Phe Leu Leu 
            20                  25                  30          
Leu Ser Ser Asn Ile Ala Val 
        35                  

<210> 58
<211> 45
<212> PRT
<213> Artificial Sequence


<220> 
<223> L15

<400> 58
Pro Thr Val Lys Asn Ser Pro Lys Ile Phe Cys Leu Ser Ser Ser Pro 
1               5                   10                  15      
Tyr Leu Ala Phe Asn Leu Glu Tyr Leu Ser Leu Arg Ile Phe Ser Thr 
            20                  25                  30          
Leu Ser Lys Cys Ser Asn Thr Leu Leu Thr Ser Leu Ser 
        35                  40                  45  

<210> 59
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> L16

<400> 59
Ser Asn Gln Leu Lys Arg Leu Trp Leu Trp Leu Leu Glu Val Arg Ser 
1               5                   10                  15      
Phe Asp Arg Thr Leu Arg Arg Pro Trp Ile His Leu Pro Ser 
            20                  25                  30  

<210> 60
<211> 1149
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1150

<400> 60
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn 
            1140                1145                

<210> 61
<211> 1124
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1150

<400> 61
Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn 
1               5                   10                  15      
Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser 
            20                  25                  30          
Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro 
        35                  40                  45              
Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu 
    50                  55                  60                  
His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu 
65                  70                  75                  80  
Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser 
                85                  90                  95      
Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser 
            100                 105                 110         
Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr 
        115                 120                 125             
Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys 
    130                 135                 140                 
Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys 
145                 150                 155                 160 
Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro 
                165                 170                 175     
Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly 
            180                 185                 190         
Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala 
        195                 200                 205             
Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe 
    210                 215                 220                 
Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met 
225                 230                 235                 240 
Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu 
                245                 250                 255     
His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu 
            260                 265                 270         
Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys 
        275                 280                 285             
Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr 
    290                 295                 300                 
Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn 
305                 310                 315                 320 
Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser 
                325                 330                 335     
Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu 
            340                 345                 350         
Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg 
        355                 360                 365             
Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe 
    370                 375                 380                 
Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys 
385                 390                 395                 400 
Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys 
                405                 410                 415     
Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser 
            420                 425                 430         
Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu 
        435                 440                 445             
Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp 
    450                 455                 460                 
Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser 
465                 470                 475                 480 
Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys 
                485                 490                 495     
Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu 
            500                 505                 510         
Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser 
        515                 520                 525             
Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val 
    530                 535                 540                 
Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser 
545                 550                 555                 560 
Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val 
                565                 570                 575     
Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu 
            580                 585                 590         
Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro 
        595                 600                 605             
Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala 
    610                 615                 620                 
Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser 
625                 630                 635                 640 
Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn 
                645                 650                 655     
Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr 
            660                 665                 670         
Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro 
        675                 680                 685             
His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala 
    690                 695                 700                 
Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro 
705                 710                 715                 720 
Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu 
                725                 730                 735     
Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe 
            740                 745                 750         
Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu 
        755                 760                 765             
Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn 
    770                 775                 780                 
Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly 
785                 790                 795                 800 
Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly 
                805                 810                 815     
Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr 
            820                 825                 830         
Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr 
        835                 840                 845             
Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn 
    850                 855                 860                 
Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly 
865                 870                 875                 880 
Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu 
                885                 890                 895     
Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr 
            900                 905                 910         
Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg 
        915                 920                 925             
Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu 
    930                 935                 940                 
Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu 
945                 950                 955                 960 
Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu 
                965                 970                 975     
Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala 
            980                 985                 990         
Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu 
        995                 1000                1005            
Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser 
    1010                1015                1020                
Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe 
1025                1030                1035                1040
Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met 
                1045                1050                1055    
Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu 
            1060                1065                1070        
Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr 
        1075                1080                1085            
Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr 
    1090                1095                1100                
Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg 
1105                1110                1115                1120
Gln Ala Gln Asp 
                

<210> 62
<211> 1139
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1140

<400> 62
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr 
            

<210> 63
<211> 1134
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1140

<400> 63
Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly Leu 
1               5                   10                  15      
Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg Lys 
            20                  25                  30          
Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr 
        35                  40                  45              
Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly 
    50                  55                  60                  
Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val Pro Glu Ala 
65                  70                  75                  80  
Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn 
                85                  90                  95      
Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu 
            100                 105                 110         
Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr 
        115                 120                 125             
Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly 
    130                 135                 140                 
Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro 
145                 150                 155                 160 
Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln 
                165                 170                 175     
Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly 
            180                 185                 190         
Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly 
        195                 200                 205             
Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe 
    210                 215                 220                 
Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu 
225                 230                 235                 240 
Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro 
                245                 250                 255     
Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly 
            260                 265                 270         
Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe 
        275                 280                 285             
Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg 
    290                 295                 300                 
Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr 
305                 310                 315                 320 
Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln 
                325                 330                 335     
Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser 
            340                 345                 350         
Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly 
        355                 360                 365             
Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln 
    370                 375                 380                 
Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro 
385                 390                 395                 400 
Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln 
                405                 410                 415     
Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile 
            420                 425                 430         
Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met 
        435                 440                 445             
Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro 
    450                 455                 460                 
Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe 
465                 470                 475                 480 
Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His 
                485                 490                 495     
Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu 
            500                 505                 510         
Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln 
        515                 520                 525             
Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala 
    530                 535                 540                 
Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu 
545                 550                 555                 560 
Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile 
                565                 570                 575     
Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp 
            580                 585                 590         
Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile 
        595                 600                 605             
Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu 
    610                 615                 620                 
Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr 
625                 630                 635                 640 
Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu 
                645                 650                 655     
Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe 
            660                 665                 670         
Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala 
        675                 680                 685             
Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg 
    690                 695                 700                 
Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala 
705                 710                 715                 720 
Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile 
                725                 730                 735     
Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu 
            740                 745                 750         
Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala 
        755                 760                 765             
Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu 
    770                 775                 780                 
Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg 
785                 790                 795                 800 
Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val 
                805                 810                 815     
Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu 
            820                 825                 830         
Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly 
        835                 840                 845             
Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile 
    850                 855                 860                 
Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln 
865                 870                 875                 880 
Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu 
                885                 890                 895     
Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala 
            900                 905                 910         
Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu 
        915                 920                 925             
Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile 
    930                 935                 940                 
Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr 
945                 950                 955                 960 
Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser 
                965                 970                 975     
Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu 
            980                 985                 990         
Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala 
        995                 1000                1005            
Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp 
    1010                1015                1020                
Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu 
1025                1030                1035                1040
Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly 
                1045                1050                1055    
Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser 
            1060                1065                1070        
Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp 
        1075                1080                1085            
Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln 
    1090                1095                1100                
Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro 
1105                1110                1115                1120
Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
                1125                1130                

<210> 64
<211> 1187
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1188

<400> 64
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr 
1185        

<210> 65
<211> 1086
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1188

<400> 65
Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly 
1               5                   10                  15      
Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val Pro Glu Ala 
            20                  25                  30          
Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn 
        35                  40                  45              
Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu 
    50                  55                  60                  
Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr 
65                  70                  75                  80  
Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly 
                85                  90                  95      
Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro 
            100                 105                 110         
Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln 
        115                 120                 125             
Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly 
    130                 135                 140                 
Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly 
145                 150                 155                 160 
Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe 
                165                 170                 175     
Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu 
            180                 185                 190         
Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro 
        195                 200                 205             
Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly 
    210                 215                 220                 
Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe 
225                 230                 235                 240 
Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg 
                245                 250                 255     
Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr 
            260                 265                 270         
Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln 
        275                 280                 285             
Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser 
    290                 295                 300                 
Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly 
305                 310                 315                 320 
Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln 
                325                 330                 335     
Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro 
            340                 345                 350         
Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln 
        355                 360                 365             
Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile 
    370                 375                 380                 
Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met 
385                 390                 395                 400 
Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro 
                405                 410                 415     
Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe 
            420                 425                 430         
Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His 
        435                 440                 445             
Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu 
    450                 455                 460                 
Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln 
465                 470                 475                 480 
Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala 
                485                 490                 495     
Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu 
            500                 505                 510         
Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile 
        515                 520                 525             
Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp 
    530                 535                 540                 
Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile 
545                 550                 555                 560 
Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu 
                565                 570                 575     
Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr 
            580                 585                 590         
Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu 
        595                 600                 605             
Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe 
    610                 615                 620                 
Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala 
625                 630                 635                 640 
Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg 
                645                 650                 655     
Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala 
            660                 665                 670         
Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile 
        675                 680                 685             
Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu 
    690                 695                 700                 
Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala 
705                 710                 715                 720 
Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu 
                725                 730                 735     
Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg 
            740                 745                 750         
Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val 
        755                 760                 765             
Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu 
    770                 775                 780                 
Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly 
785                 790                 795                 800 
Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile 
                805                 810                 815     
Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln 
            820                 825                 830         
Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu 
        835                 840                 845             
Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala 
    850                 855                 860                 
Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu 
865                 870                 875                 880 
Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile 
                885                 890                 895     
Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr 
            900                 905                 910         
Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser 
        915                 920                 925             
Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu 
    930                 935                 940                 
Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala 
945                 950                 955                 960 
Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp 
                965                 970                 975     
Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu 
            980                 985                 990         
Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly 
        995                 1000                1005            
Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser 
    1010                1015                1020                
Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp 
1025                1030                1035                1040
Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln 
                1045                1050                1055    
Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro 
            1060                1065                1070        
Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
        1075                1080                1085    

<210> 66
<211> 1250
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaN

<400> 66
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Leu Ser 
            1140                1145                1150        
Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly 
        1155                1160                1165            
Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys 
    1170                1175                1180                
Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly 
1185                1190                1195                1200
Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg 
                1205                1210                1215    
Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro 
            1220                1225                1230        
Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly 
        1235                1240                1245            
Leu Pro 
    1250

<210> 67
<211> 1160
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaC

<400> 67
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg 
        35                  40                  45              
Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys 
    50                  55                  60                  
Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp 
65                  70                  75                  80  
Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met 
                85                  90                  95      
Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile 
            100                 105                 110         
Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg 
        115                 120                 125             
Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu 
    130                 135                 140                 
Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe 
145                 150                 155                 160 
Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly 
                165                 170                 175     
Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly 
            180                 185                 190         
Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser 
        195                 200                 205             
Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro 
    210                 215                 220                 
Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln 
225                 230                 235                 240 
His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser 
                245                 250                 255     
His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe 
            260                 265                 270         
Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro 
        275                 280                 285             
Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe 
    290                 295                 300                 
Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val 
305                 310                 315                 320 
Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp 
                325                 330                 335     
Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser 
            340                 345                 350         
Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln 
        355                 360                 365             
Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr 
    370                 375                 380                 
Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln 
385                 390                 395                 400 
Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn 
                405                 410                 415     
Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser 
            420                 425                 430         
Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser 
        435                 440                 445             
Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val 
    450                 455                 460                 
Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro 
465                 470                 475                 480 
Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu 
                485                 490                 495     
Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His 
            500                 505                 510         
Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala 
        515                 520                 525             
Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile 
    530                 535                 540                 
Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val 
545                 550                 555                 560 
Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser 
                565                 570                 575     
Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg 
            580                 585                 590         
Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr 
        595                 600                 605             
Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val 
    610                 615                 620                 
Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala 
625                 630                 635                 640 
Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu 
                645                 650                 655     
Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe 
            660                 665                 670         
Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe 
        675                 680                 685             
Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu 
    690                 695                 700                 
Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu 
705                 710                 715                 720 
Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala 
                725                 730                 735     
Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His 
            740                 745                 750         
Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala 
        755                 760                 765             
Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln 
    770                 775                 780                 
Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro 
785                 790                 795                 800 
Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile 
                805                 810                 815     
Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys 
            820                 825                 830         
Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly 
        835                 840                 845             
Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly 
    850                 855                 860                 
Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser 
865                 870                 875                 880 
Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu 
                885                 890                 895     
Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu 
            900                 905                 910         
Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly 
        915                 920                 925             
Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser 
    930                 935                 940                 
Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly 
945                 950                 955                 960 
Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro 
                965                 970                 975     
Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala 
            980                 985                 990         
Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg 
        995                 1000                1005            
Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys 
    1010                1015                1020                
Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr 
1025                1030                1035                1040
Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met 
                1045                1050                1055    
Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val 
            1060                1065                1070        
Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg 
        1075                1080                1085            
His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg 
    1090                1095                1100                
Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu 
1105                1110                1115                1120
Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala 
                1125                1130                1135    
Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala 
            1140                1145                1150        
Gly Ala Ser Arg Gln Ala Gln Asp 
        1155                1160

<210> 68
<211> 1240
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaN

<400> 68
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
            1140                1145                1150        
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
        1155                1160                1165            
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
    1170                1175                1180                
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
1185                1190                1195                1200
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
                1205                1210                1215    
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
            1220                1225                1230        
Leu Lys Gln Val Asp Gly Leu Pro 
        1235                1240

<210> 69
<211> 1170
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaCmut

<400> 69
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe 
        35                  40                  45              
Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln 
    50                  55                  60                  
Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly 
65                  70                  75                  80  
Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln 
                85                  90                  95      
Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His 
            100                 105                 110         
Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe 
        115                 120                 125             
Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe 
    130                 135                 140                 
Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 
145                 150                 155                 160 
Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp 
                165                 170                 175     
Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu 
            180                 185                 190         
Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly 
        195                 200                 205             
Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala 
    210                 215                 220                 
His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln 
225                 230                 235                 240 
Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu 
                245                 250                 255     
Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala 
            260                 265                 270         
Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
        275                 280                 285             
Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro 
    290                 295                 300                 
Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly 
305                 310                 315                 320 
Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly 
                325                 330                 335     
Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys 
            340                 345                 350         
Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr 
        355                 360                 365             
Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser 
    370                 375                 380                 
Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 
385                 390                 395                 400 
Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr 
                405                 410                 415     
Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val 
            420                 425                 430         
Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp 
        435                 440                 445             
Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro 
    450                 455                 460                 
Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu 
465                 470                 475                 480 
Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser 
                485                 490                 495     
Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile 
            500                 505                 510         
Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu 
        515                 520                 525             
Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg 
    530                 535                 540                 
Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu 
545                 550                 555                 560 
Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp 
                565                 570                 575     
Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala 
            580                 585                 590         
Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His 
        595                 600                 605             
Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn 
    610                 615                 620                 
Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 
625                 630                 635                 640 
Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn 
                645                 650                 655     
Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile 
            660                 665                 670         
Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala 
        675                 680                 685             
Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser 
    690                 695                 700                 
Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu 
705                 710                 715                 720 
Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe 
                725                 730                 735     
Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr 
            740                 745                 750         
Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His 
        755                 760                 765             
Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val 
    770                 775                 780                 
Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser 
785                 790                 795                 800 
Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp 
                805                 810                 815     
Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr 
            820                 825                 830         
Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser 
        835                 840                 845             
Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys 
    850                 855                 860                 
Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 
865                 870                 875                 880 
Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala 
                885                 890                 895     
Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly 
            900                 905                 910         
Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu 
        915                 920                 925             
His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile 
    930                 935                 940                 
Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr 
945                 950                 955                 960 
Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu 
                965                 970                 975     
Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp 
            980                 985                 990         
Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn 
        995                 1000                1005            
Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser 
    1010                1015                1020                
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met 
1025                1030                1035                1040
Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser 
                1045                1050                1055    
Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys 
            1060                1065                1070        
Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly 
        1075                1080                1085            
Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln 
    1090                1095                1100                
Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 
1105                1110                1115                1120
Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr 
                1125                1130                1135    
Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser 
            1140                1145                1150        
His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala 
        1155                1160                1165            
Gln Asp 
    1170

<210> 70
<211> 1288
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1188-CfaN

<400> 70
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
1185                1190                1195                1200
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
                1205                1210                1215    
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
            1220                1225                1230        
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
        1235                1240                1245            
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
    1250                1255                1260                
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
1265                1270                1275                1280
Leu Lys Gln Val Asp Gly Leu Pro 
                1285            

<210> 71
<211> 1122
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1188-Cfacmut

<400> 71
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln 
        35                  40                  45              
Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His 
    50                  55                  60                  
Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe 
65                  70                  75                  80  
Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe 
                85                  90                  95      
Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 
            100                 105                 110         
Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp 
        115                 120                 125             
Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu 
    130                 135                 140                 
Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly 
145                 150                 155                 160 
Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala 
                165                 170                 175     
His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln 
            180                 185                 190         
Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu 
        195                 200                 205             
Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala 
    210                 215                 220                 
Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
225                 230                 235                 240 
Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro 
                245                 250                 255     
Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly 
            260                 265                 270         
Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly 
        275                 280                 285             
Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys 
    290                 295                 300                 
Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr 
305                 310                 315                 320 
Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser 
                325                 330                 335     
Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 
            340                 345                 350         
Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr 
        355                 360                 365             
Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val 
    370                 375                 380                 
Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp 
385                 390                 395                 400 
Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro 
                405                 410                 415     
Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu 
            420                 425                 430         
Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser 
        435                 440                 445             
Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile 
    450                 455                 460                 
Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu 
465                 470                 475                 480 
Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg 
                485                 490                 495     
Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu 
            500                 505                 510         
Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp 
        515                 520                 525             
Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala 
    530                 535                 540                 
Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His 
545                 550                 555                 560 
Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn 
                565                 570                 575     
Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 
            580                 585                 590         
Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn 
        595                 600                 605             
Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile 
    610                 615                 620                 
Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala 
625                 630                 635                 640 
Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser 
                645                 650                 655     
Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu 
            660                 665                 670         
Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe 
        675                 680                 685             
Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr 
    690                 695                 700                 
Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His 
705                 710                 715                 720 
Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val 
                725                 730                 735     
Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser 
            740                 745                 750         
Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp 
        755                 760                 765             
Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr 
    770                 775                 780                 
Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser 
785                 790                 795                 800 
Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys 
                805                 810                 815     
Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 
            820                 825                 830         
Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala 
        835                 840                 845             
Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly 
    850                 855                 860                 
Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu 
865                 870                 875                 880 
His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile 
                885                 890                 895     
Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr 
            900                 905                 910         
Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu 
        915                 920                 925             
Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp 
    930                 935                 940                 
Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn 
945                 950                 955                 960 
Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser 
                965                 970                 975     
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met 
            980                 985                 990         
Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser 
        995                 1000                1005            
Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys 
    1010                1015                1020                
Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly 
1025                1030                1035                1040
Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln 
                1045                1050                1055    
Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 
            1060                1065                1070        
Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr 
        1075                1080                1085            
Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser 
    1090                1095                1100                
His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala 
1105                1110                1115                1120
Gln Asp 
        

<210> 72
<211> 1349
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaN-SopE

<400> 72
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Leu Ser 
            1140                1145                1150        
Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly 
        1155                1160                1165            
Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys 
    1170                1175                1180                
Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly 
1185                1190                1195                1200
Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg 
                1205                1210                1215    
Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro 
            1220                1225                1230        
Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly 
        1235                1240                1245            
Leu Pro Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys 
    1250                1255                1260                
Gln Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu 
1265                1270                1275                1280
Ala Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser 
                1285                1290                1295    
Lys Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala 
            1300                1305                1310        
Thr His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr 
        1315                1320                1325            
Asn Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp 
    1330                1335                1340                
Ile Arg Gly Ser Ala 
1345                

<210> 73
<211> 1259
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaC-SopE

<400> 73
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  
Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      
Arg Gly Ser Ala Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln 
            100                 105                 110         
Asn Val Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys 
        115                 120                 125             
Asn Gly Leu Val Ala Ser Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr 
    130                 135                 140                 
Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu 
145                 150                 155                 160 
Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala 
                165                 170                 175     
His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn 
            180                 185                 190         
Glu Leu Met Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val 
        195                 200                 205             
Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe 
    210                 215                 220                 
Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu 
225                 230                 235                 240 
Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu 
                245                 250                 255     
Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe 
            260                 265                 270         
Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro 
        275                 280                 285             
Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn 
    290                 295                 300                 
Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro 
305                 310                 315                 320 
Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu 
                325                 330                 335     
Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr 
            340                 345                 350         
Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr 
        355                 360                 365             
Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly 
    370                 375                 380                 
Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr 
385                 390                 395                 400 
Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu 
                405                 410                 415     
Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys 
            420                 425                 430         
Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys 
        435                 440                 445             
Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys 
    450                 455                 460                 
Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu 
465                 470                 475                 480 
Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro 
                485                 490                 495     
Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr 
            500                 505                 510         
Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile 
        515                 520                 525             
Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly 
    530                 535                 540                 
Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu 
545                 550                 555                 560 
Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser 
                565                 570                 575     
Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu 
            580                 585                 590         
Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys 
        595                 600                 605             
Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile 
    610                 615                 620                 
Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile 
625                 630                 635                 640 
Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu 
                645                 650                 655     
Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val 
            660                 665                 670         
Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile 
        675                 680                 685             
Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val 
    690                 695                 700                 
Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn 
705                 710                 715                 720 
Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln 
                725                 730                 735     
Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu 
            740                 745                 750         
Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser 
        755                 760                 765             
Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala 
    770                 775                 780                 
Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu 
785                 790                 795                 800 
Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg 
                805                 810                 815     
Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile 
            820                 825                 830         
Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly 
        835                 840                 845             
Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn 
    850                 855                 860                 
Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu 
865                 870                 875                 880 
Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr 
                885                 890                 895     
Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln 
            900                 905                 910         
Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu 
        915                 920                 925             
Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu 
    930                 935                 940                 
Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn 
945                 950                 955                 960 
Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr 
                965                 970                 975     
Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn 
            980                 985                 990         
Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala 
        995                 1000                1005            
Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg 
    1010                1015                1020                
Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser 
1025                1030                1035                1040
Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr 
                1045                1050                1055    
Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile 
            1060                1065                1070        
Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp 
        1075                1080                1085            
Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg 
    1090                1095                1100                
Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu 
1105                1110                1115                1120
Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys 
                1125                1130                1135    
Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile 
            1140                1145                1150        
Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu 
        1155                1160                1165            
Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln 
    1170                1175                1180                
Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser 
1185                1190                1195                1200
Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu 
                1205                1210                1215    
Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val 
            1220                1225                1230        
Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro 
        1235                1240                1245            
Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
    1250                1255                

<210> 74
<211> 1339
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaN-SopE

<400> 74
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
            1140                1145                1150        
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
        1155                1160                1165            
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
    1170                1175                1180                
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
1185                1190                1195                1200
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
                1205                1210                1215    
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
            1220                1225                1230        
Leu Lys Gln Val Asp Gly Leu Pro Thr Lys Ile Thr Leu Ser Pro Gln 
        1235                1240                1245            
Asn Phe Arg Ile Gln Lys Gln Glu Thr Thr Leu Leu Lys Glu Lys Ser 
    1250                1255                1260                
Thr Glu Lys Asn Ser Leu Ala Lys Ser Ile Leu Ala Val Lys Asn His 
1265                1270                1275                1280
Phe Ile Glu Leu Arg Ser Lys Leu Ser Glu Arg Phe Ile Ser His Lys 
                1285                1290                1295    
Asn Thr Glu Ser Ser Ala Thr His Phe His Arg Gly Ser Ala Ser Glu 
            1300                1305                1310        
Gly Arg Ala Val Leu Thr Asn Lys Val Val Lys Asp Phe Met Leu Gln 
        1315                1320                1325            
Thr Leu Asn Asp Ile Asp Ile Arg Gly Ser Ala 
    1330                1335                

<210> 75
<211> 1269
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaCmut-SopE

<400> 75
Met Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      
Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          
Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              
Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  
His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  
Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      
Arg Gly Ser Ala Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln 
            100                 105                 110         
Asn Val Tyr Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys 
        115                 120                 125             
Asn Gly Leu Val Ala Ser Asn Cys Ser Gly Thr Pro Leu Phe Leu Lys 
    130                 135                 140                 
Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys 
145                 150                 155                 160 
Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser 
                165                 170                 175     
Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr 
            180                 185                 190         
Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val 
        195                 200                 205             
Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu 
    210                 215                 220                 
Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala 
225                 230                 235                 240 
Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser 
                245                 250                 255     
Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val 
            260                 265                 270         
Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln 
        275                 280                 285             
Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu 
    290                 295                 300                 
Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala 
305                 310                 315                 320 
Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro 
                325                 330                 335     
Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln 
            340                 345                 350         
Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp 
        355                 360                 365             
Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu 
    370                 375                 380                 
Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr 
385                 390                 395                 400 
Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp 
                405                 410                 415     
Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn 
            420                 425                 430         
Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu 
        435                 440                 445             
Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro 
    450                 455                 460                 
Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro 
465                 470                 475                 480 
Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro 
                485                 490                 495     
Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln 
            500                 505                 510         
Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp 
        515                 520                 525             
Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser 
    530                 535                 540                 
Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly 
545                 550                 555                 560 
Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu 
                565                 570                 575     
Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg 
            580                 585                 590         
Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu 
        595                 600                 605             
Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val 
    610                 615                 620                 
Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro 
625                 630                 635                 640 
Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro 
                645                 650                 655     
Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr 
            660                 665                 670         
Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe 
        675                 680                 685             
Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys 
    690                 695                 700                 
Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp 
705                 710                 715                 720 
Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly 
                725                 730                 735     
Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser 
            740                 745                 750         
Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp 
        755                 760                 765             
Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro 
    770                 775                 780                 
Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile 
785                 790                 795                 800 
Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg 
                805                 810                 815     
Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe 
            820                 825                 830         
Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln 
        835                 840                 845             
Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn 
    850                 855                 860                 
Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val 
865                 870                 875                 880 
Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe 
                885                 890                 895     
Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp 
            900                 905                 910         
Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly 
        915                 920                 925             
Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro 
    930                 935                 940                 
Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro 
945                 950                 955                 960 
Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr 
                965                 970                 975     
Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala 
            980                 985                 990         
Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln 
        995                 1000                1005            
Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr 
    1010                1015                1020                
Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala 
1025                1030                1035                1040
Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu 
                1045                1050                1055    
Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys 
            1060                1065                1070        
Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val 
        1075                1080                1085            
Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met 
    1090                1095                1100                
Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val 
1105                1110                1115                1120
Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu 
                1125                1130                1135    
Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His 
            1140                1145                1150        
Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys 
        1155                1160                1165            
Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe 
    1170                1175                1180                
Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn 
1185                1190                1195                1200
Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln 
                1205                1210                1215    
Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val 
            1220                1225                1230        
Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln 
        1235                1240                1245            
Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser 
    1250                1255                1260                
Arg Gln Ala Gln Asp 
1265                

<210> 76
<211> 1263
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaN-DD1

<400> 76
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Leu Ser 
            1140                1145                1150        
Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly 
        1155                1160                1165            
Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys 
    1170                1175                1180                
Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly 
1185                1190                1195                1200
Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg 
                1205                1210                1215    
Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro 
            1220                1225                1230        
Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly 
        1235                1240                1245            
Leu Pro Arg Ile Ser Phe Gly Ser Pro Pro Pro Met Ala Gly Gly 
    1250                1255                1260            

<210> 77
<211> 1173
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1150-CfaC-DD1

<400> 77
Met Arg Ile Ser Phe Gly Ser Pro Pro Pro Met Ala Gly Gly Val Lys 
1               5                   10                  15      
Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp Ile Gly 
            20                  25                  30          
Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu Val Ala Ser 
        35                  40                  45              
Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys 
    50                  55                  60                  
Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser 
65                  70                  75                  80  
Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr 
                85                  90                  95      
Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val 
            100                 105                 110         
Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu 
        115                 120                 125             
Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala 
    130                 135                 140                 
Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser 
145                 150                 155                 160 
Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val 
                165                 170                 175     
Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln 
            180                 185                 190         
Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu 
        195                 200                 205             
Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala 
    210                 215                 220                 
Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro 
225                 230                 235                 240 
Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln 
                245                 250                 255     
Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp 
            260                 265                 270         
Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu 
        275                 280                 285             
Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr 
    290                 295                 300                 
Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp 
305                 310                 315                 320 
Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn 
                325                 330                 335     
Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu 
            340                 345                 350         
Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro 
        355                 360                 365             
Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro 
    370                 375                 380                 
Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro 
385                 390                 395                 400 
Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln 
                405                 410                 415     
Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp 
            420                 425                 430         
Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser 
        435                 440                 445             
Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly 
    450                 455                 460                 
Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu 
465                 470                 475                 480 
Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg 
                485                 490                 495     
Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu 
            500                 505                 510         
Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val 
        515                 520                 525             
Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro 
    530                 535                 540                 
Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro 
545                 550                 555                 560 
Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr 
                565                 570                 575     
Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe 
            580                 585                 590         
Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys 
        595                 600                 605             
Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp 
    610                 615                 620                 
Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly 
625                 630                 635                 640 
Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser 
                645                 650                 655     
Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp 
            660                 665                 670         
Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro 
        675                 680                 685             
Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile 
    690                 695                 700                 
Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg 
705                 710                 715                 720 
Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe 
                725                 730                 735     
Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln 
            740                 745                 750         
Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn 
        755                 760                 765             
Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val 
    770                 775                 780                 
Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe 
785                 790                 795                 800 
Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp 
                805                 810                 815     
Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly 
            820                 825                 830         
Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro 
        835                 840                 845             
Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro 
    850                 855                 860                 
Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr 
865                 870                 875                 880 
Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala 
                885                 890                 895     
Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln 
            900                 905                 910         
Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr 
        915                 920                 925             
Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala 
    930                 935                 940                 
Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu 
945                 950                 955                 960 
Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys 
                965                 970                 975     
Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val 
            980                 985                 990         
Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met 
        995                 1000                1005            
Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val 
    1010                1015                1020                
Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu 
1025                1030                1035                1040
Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His 
                1045                1050                1055    
Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys 
            1060                1065                1070        
Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe 
        1075                1080                1085            
Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn 
    1090                1095                1100                
Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln 
1105                1110                1115                1120
Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val 
                1125                1130                1135    
Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln 
            1140                1145                1150        
Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser 
        1155                1160                1165            
Arg Gln Ala Gln Asp 
    1170            

<210> 78
<211> 1253
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaN-DD1

<400> 78
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr 
            1140                1145                1150        
Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr 
        1155                1160                1165            
Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala 
    1170                1175                1180                
Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 
1185                1190                1195                1200
Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr 
                1205                1210                1215    
Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp 
            1220                1225                1230        
Leu Lys Gln Val Asp Gly Leu Pro Arg Ile Ser Phe Gly Ser Pro Pro 
        1235                1240                1245            
Pro Met Ala Gly Gly 
    1250            

<210> 79
<211> 1183
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1140-CfaCmut-DD1

<400> 79
Met Arg Ile Ser Phe Gly Ser Pro Pro Pro Met Ala Gly Gly Val Lys 
1               5                   10                  15      
Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp Ile Gly 
            20                  25                  30          
Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu Val Ala Ser 
        35                  40                  45              
Asn Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly 
    50                  55                  60                  
Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg 
65                  70                  75                  80  
Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr 
                85                  90                  95      
Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp 
            100                 105                 110         
Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val Pro Glu 
        115                 120                 125             
Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro 
    130                 135                 140                 
Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu 
145                 150                 155                 160 
Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp 
                165                 170                 175     
Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser 
            180                 185                 190         
Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn 
        195                 200                 205             
Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro 
    210                 215                 220                 
Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu 
225                 230                 235                 240 
Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr 
                245                 250                 255     
Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg 
            260                 265                 270         
Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val 
        275                 280                 285             
Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile 
    290                 295                 300                 
Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr 
305                 310                 315                 320 
Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln 
                325                 330                 335     
Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn 
            340                 345                 350         
Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser 
        355                 360                 365             
Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe 
    370                 375                 380                 
Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys 
385                 390                 395                 400 
Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala 
                405                 410                 415     
Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu 
            420                 425                 430         
Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr 
        435                 440                 445             
Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu 
    450                 455                 460                 
Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro 
465                 470                 475                 480 
Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile 
                485                 490                 495     
Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile 
            500                 505                 510         
Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp 
        515                 520                 525             
Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala 
    530                 535                 540                 
His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu 
545                 550                 555                 560 
Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu 
                565                 570                 575     
Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val 
            580                 585                 590         
Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val 
        595                 600                 605             
Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe 
    610                 615                 620                 
Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp 
625                 630                 635                 640 
Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe 
                645                 650                 655     
Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala 
            660                 665                 670         
Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met 
        675                 680                 685             
Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala 
    690                 695                 700                 
Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr 
705                 710                 715                 720 
Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn 
                725                 730                 735     
Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly 
            740                 745                 750         
Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr 
        755                 760                 765             
Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu 
    770                 775                 780                 
Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe 
785                 790                 795                 800 
Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile 
                805                 810                 815     
Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala 
            820                 825                 830         
Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu 
        835                 840                 845             
Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala 
    850                 855                 860                 
Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu 
865                 870                 875                 880 
Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr 
                885                 890                 895     
Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser 
            900                 905                 910         
Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro 
        915                 920                 925             
Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr 
    930                 935                 940                 
Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val 
945                 950                 955                 960 
Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys 
                965                 970                 975     
Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala 
            980                 985                 990         
Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr 
        995                 1000                1005            
Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val 
    1010                1015                1020                
Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met 
1025                1030                1035                1040
Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly 
                1045                1050                1055    
Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly 
            1060                1065                1070        
Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu 
        1075                1080                1085            
Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro 
    1090                1095                1100                
Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val 
1105                1110                1115                1120
Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys 
                1125                1130                1135    
Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp 
            1140                1145                1150        
Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu 
        1155                1160                1165            
Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
    1170                1175                1180            

<210> 80
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD4

<220> 
<221> VARIANT
<222> 12
<223> X= any aminoacid, preferably Gly

<400> 80
Arg Asp Ser Phe Gly Ser Pro Pro Pro Met Ala Xaa Gly 
1               5                   10              

<210> 81
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD5

<400> 81
Gly Phe Trp Ile 
1               

<210> 82
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD6

<400> 82
Arg Phe Lys Gly 
1               

<210> 83
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD7

<400> 83
Lys Phe Tyr Lys 
1               

<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Hexahistidine

<400> 84
Gly His His His His His His Gly 
1               5               

<210> 85
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> V12

<400> 85
Thr Asn Gly Ser Val Leu Arg Glu Phe Thr Leu Leu Glu Leu Glu Val 
1               5                   10                  15      
Val Thr Arg Asn Thr Glu Leu 
            20              

<210> 86
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> T1

<400> 86
Ser Val Leu Glu Glu Asn Arg Pro Phe Ala Gln Gln Leu Ser Asn Val 
1               5                   10                  15      
Tyr Phe Thr Ile Leu 
            20      

<210> 87
<211> 1176
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1177

<400> 87
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr 
    1170                1175    

<210> 88
<211> 1097
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1177

<400> 88
Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val 
1               5                   10                  15      
Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu 
            20                  25                  30          
Met Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys 
        35                  40                  45              
Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His 
    50                  55                  60                  
Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp 
65                  70                  75                  80  
Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile 
                85                  90                  95      
Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly 
            100                 105                 110         
Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu 
        115                 120                 125             
Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys 
    130                 135                 140                 
Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu 
145                 150                 155                 160 
Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu 
                165                 170                 175     
Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg 
            180                 185                 190         
Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val 
        195                 200                 205             
Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr 
    210                 215                 220                 
Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe 
225                 230                 235                 240 
Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp 
                245                 250                 255     
Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly 
            260                 265                 270         
Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro 
        275                 280                 285             
Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr 
    290                 295                 300                 
Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu 
305                 310                 315                 320 
Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro 
                325                 330                 335     
Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg 
            340                 345                 350         
Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser 
        355                 360                 365             
Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile 
    370                 375                 380                 
Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu 
385                 390                 395                 400 
Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly 
                405                 410                 415     
Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His 
            420                 425                 430         
Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp 
        435                 440                 445             
His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg 
    450                 455                 460                 
Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val 
465                 470                 475                 480 
Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr 
                485                 490                 495     
Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe 
            500                 505                 510         
Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu 
        515                 520                 525             
Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro 
    530                 535                 540                 
Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser 
545                 550                 555                 560 
Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys 
                565                 570                 575     
Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu 
            580                 585                 590         
Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu 
        595                 600                 605             
Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu 
    610                 615                 620                 
Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe 
625                 630                 635                 640 
Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu 
                645                 650                 655     
Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu 
            660                 665                 670         
Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu 
        675                 680                 685             
His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe 
    690                 695                 700                 
Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val 
705                 710                 715                 720 
Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu 
                725                 730                 735     
Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile 
            740                 745                 750         
Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr 
        755                 760                 765             
Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val 
    770                 775                 780                 
Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala 
785                 790                 795                 800 
Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr 
                805                 810                 815     
Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser 
            820                 825                 830         
Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp 
        835                 840                 845             
Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg 
    850                 855                 860                 
Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys 
865                 870                 875                 880 
Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser 
                885                 890                 895     
Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys 
            900                 905                 910         
Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln 
        915                 920                 925             
Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly 
    930                 935                 940                 
Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu 
945                 950                 955                 960 
Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly 
                965                 970                 975     
Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr 
            980                 985                 990         
Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro 
        995                 1000                1005            
Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu 
    1010                1015                1020                
Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala 
1025                1030                1035                1040
Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu 
                1045                1050                1055    
Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe 
            1060                1065                1070        
Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala 
        1075                1080                1085            
Ala Gly Ala Ser Arg Gln Ala Gln Asp 
    1090                1095        

<210> 89
<211> 1178
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1179

<400> 89
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser 
    1170                1175            

<210> 90
<211> 1095
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1179

<400> 90
Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His Val Asp Asp 
1               5                   10                  15      
Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp 
            20                  25                  30          
Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly 
        35                  40                  45              
Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala 
    50                  55                  60                  
Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly 
65                  70                  75                  80  
Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu 
                85                  90                  95      
Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala 
            100                 105                 110         
Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro 
        115                 120                 125             
Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro 
    130                 135                 140                 
Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu 
145                 150                 155                 160 
Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His 
                165                 170                 175     
Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser His 
            180                 185                 190         
Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu 
        195                 200                 205             
Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala 
    210                 215                 220                 
Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser 
225                 230                 235                 240 
Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu 
                245                 250                 255     
Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu 
            260                 265                 270         
Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val 
        275                 280                 285             
Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val 
    290                 295                 300                 
Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met 
305                 310                 315                 320 
Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg 
                325                 330                 335     
Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile 
            340                 345                 350         
Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu 
        355                 360                 365             
Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile 
    370                 375                 380                 
Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly 
385                 390                 395                 400 
Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile 
                405                 410                 415     
Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu 
            420                 425                 430         
Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala 
        435                 440                 445             
Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser 
    450                 455                 460                 
Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser 
465                 470                 475                 480 
Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu 
                485                 490                 495     
Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met 
            500                 505                 510         
Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val 
        515                 520                 525             
Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr 
    530                 535                 540                 
Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser 
545                 550                 555                 560 
Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr 
                565                 570                 575     
Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr 
            580                 585                 590         
Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp 
        595                 600                 605             
Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile 
    610                 615                 620                 
Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn 
625                 630                 635                 640 
Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile 
                645                 650                 655     
Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu 
            660                 665                 670         
Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser 
        675                 680                 685             
Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met 
    690                 695                 700                 
Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg 
705                 710                 715                 720 
His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile 
                725                 730                 735     
Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr 
            740                 745                 750         
Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile 
        755                 760                 765             
Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val 
    770                 775                 780                 
Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys 
785                 790                 795                 800 
Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly 
                805                 810                 815     
Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val 
            820                 825                 830         
His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu 
        835                 840                 845             
Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val 
    850                 855                 860                 
Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu 
865                 870                 875                 880 
Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly 
                885                 890                 895     
Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro 
            900                 905                 910         
Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg 
        915                 920                 925             
Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala 
    930                 935                 940                 
Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr 
945                 950                 955                 960 
Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile 
                965                 970                 975     
Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys 
            980                 985                 990         
Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu 
        995                 1000                1005            
Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His 
    1010                1015                1020                
Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile 
1025                1030                1035                1040
Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr 
                1045                1050                1055    
Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys 
            1060                1065                1070        
Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly 
        1075                1080                1085            
Ala Ser Arg Gln Ala Gln Asp 
    1090                1095

<210> 91
<211> 1277
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1177-CfaN

<400> 91
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Leu Ser Tyr Asp Thr Glu Ile 
    1170                1175                1180                
Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly Lys Ile Val Glu Glu 
1185                1190                1195                1200
Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys Asn Gly Phe Val Tyr 
                1205                1210                1215    
Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly Glu Gln Glu Val Phe 
            1220                1225                1230        
Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg Ala Thr Lys Asp His 
        1235                1240                1245            
Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe 
    1250                1255                1260                
Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly Leu Pro 
1265                1270                1275        

<210> 92
<211> 1133
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1177-CfaCmut

<400> 92
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys 
        35                  40                  45              
Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp 
    50                  55                  60                  
Val Asn Glu Leu Met Asp Val Val Leu His His Val Pro Glu Ala Lys 
65                  70                  75                  80  
Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys 
                85                  90                  95      
Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu 
            100                 105                 110         
Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro 
        115                 120                 125             
Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro 
    130                 135                 140                 
Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg 
145                 150                 155                 160 
His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp 
                165                 170                 175     
Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln 
            180                 185                 190         
Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr 
        195                 200                 205             
Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln 
    210                 215                 220                 
His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro 
225                 230                 235                 240 
Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro 
                245                 250                 255     
Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln 
            260                 265                 270         
Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr 
        275                 280                 285             
Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys 
    290                 295                 300                 
Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro 
305                 310                 315                 320 
Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys 
                325                 330                 335     
Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr 
            340                 345                 350         
Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly 
        355                 360                 365             
Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp 
    370                 375                 380                 
Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala 
385                 390                 395                 400 
Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg 
                405                 410                 415     
Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr 
            420                 425                 430         
Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn 
        435                 440                 445             
Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp 
    450                 455                 460                 
Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn 
465                 470                 475                 480 
Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn 
                485                 490                 495     
Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr 
            500                 505                 510         
Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu 
        515                 520                 525             
Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile 
    530                 535                 540                 
Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr 
545                 550                 555                 560 
Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser 
                565                 570                 575     
Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile 
            580                 585                 590         
Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly 
        595                 600                 605             
Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val 
    610                 615                 620                 
Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro 
625                 630                 635                 640 
Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser 
                645                 650                 655     
Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile 
            660                 665                 670         
Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val 
        675                 680                 685             
Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly 
    690                 695                 700                 
Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg 
705                 710                 715                 720 
Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly 
                725                 730                 735     
Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu 
            740                 745                 750         
Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu 
        755                 760                 765             
Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu 
    770                 775                 780                 
Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu 
785                 790                 795                 800 
His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp 
                805                 810                 815     
Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly 
            820                 825                 830         
Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp 
        835                 840                 845             
Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu 
    850                 855                 860                 
Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe 
865                 870                 875                 880 
Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr 
                885                 890                 895     
Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn 
            900                 905                 910         
Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala 
        915                 920                 925             
Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala 
    930                 935                 940                 
Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly 
945                 950                 955                 960 
Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile 
                965                 970                 975     
Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu 
            980                 985                 990         
Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe 
        995                 1000                1005            
Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly 
    1010                1015                1020                
Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro 
1025                1030                1035                1040
Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser 
                1045                1050                1055    
Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser 
            1060                1065                1070        
Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser 
        1075                1080                1085            
Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val 
    1090                1095                1100                
Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu 
1105                1110                1115                1120
His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
                1125                1130            

<210> 93
<211> 1279
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1179-CfaN

<400> 93
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Leu Ser Tyr Asp Thr 
    1170                1175                1180                
Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu Pro Ile Gly Lys Ile Val 
1185                1190                1195                1200
Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys Asn Gly Phe 
                1205                1210                1215    
Val Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly Glu Gln Glu 
            1220                1225                1230        
Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Ile Ile Arg Ala Thr Lys 
        1235                1240                1245            
Asp His Lys Phe Met Thr Thr Asp Gly Gln Met Leu Pro Ile Asp Glu 
    1250                1255                1260                
Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln Val Asp Gly Leu Pro 
1265                1270                1275                

<210> 94
<211> 1131
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1179-CfaCmut

<400> 94
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          
Val Ala Ser Asn Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala 
        35                  40                  45              
His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn 
    50                  55                  60                  
Glu Leu Met Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val 
65                  70                  75                  80  
Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe 
                85                  90                  95      
Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu 
            100                 105                 110         
Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu 
        115                 120                 125             
Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe 
    130                 135                 140                 
Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro 
145                 150                 155                 160 
Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn 
                165                 170                 175     
Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro 
            180                 185                 190         
Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu 
        195                 200                 205             
Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr 
    210                 215                 220                 
Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr 
225                 230                 235                 240 
Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly 
                245                 250                 255     
Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr 
            260                 265                 270         
Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu 
        275                 280                 285             
Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys 
    290                 295                 300                 
Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys 
305                 310                 315                 320 
Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys 
                325                 330                 335     
Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu 
            340                 345                 350         
Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro 
        355                 360                 365             
Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr 
    370                 375                 380                 
Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile 
385                 390                 395                 400 
Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly 
                405                 410                 415     
Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu 
            420                 425                 430         
Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser 
        435                 440                 445             
Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu 
    450                 455                 460                 
Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys 
465                 470                 475                 480 
Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile 
                485                 490                 495     
Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile 
            500                 505                 510         
Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu 
        515                 520                 525             
Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val 
    530                 535                 540                 
Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile 
545                 550                 555                 560 
Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val 
                565                 570                 575     
Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn 
            580                 585                 590         
Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln 
        595                 600                 605             
Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu 
    610                 615                 620                 
Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser 
625                 630                 635                 640 
Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala 
                645                 650                 655     
Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu 
            660                 665                 670         
Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg 
        675                 680                 685             
Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile 
    690                 695                 700                 
Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly 
705                 710                 715                 720 
Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn 
                725                 730                 735     
Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu 
            740                 745                 750         
Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr 
        755                 760                 765             
Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln 
    770                 775                 780                 
Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu 
785                 790                 795                 800 
Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu 
                805                 810                 815     
Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn 
            820                 825                 830         
Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr 
        835                 840                 845             
Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn 
    850                 855                 860                 
Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala 
865                 870                 875                 880 
Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg 
                885                 890                 895     
Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser 
            900                 905                 910         
Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr 
        915                 920                 925             
Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile 
    930                 935                 940                 
Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp 
945                 950                 955                 960 
Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg 
                965                 970                 975     
Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu 
            980                 985                 990         
Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys 
        995                 1000                1005            
Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile 
    1010                1015                1020                
Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu 
1025                1030                1035                1040
Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln 
                1045                1050                1055    
Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser 
            1060                1065                1070        
Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu 
        1075                1080                1085            
Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val 
    1090                1095                1100                
Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro 
1105                1110                1115                1120
Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
                1125                1130    

<210> 95
<211> 1095
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1096

<400> 95
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr 
    1090                1095

<210> 96
<211> 1178
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1096

<400> 96
Ser Arg Arg Ser Ile Trp Asp Leu Leu Leu Lys Tyr Arg Ser Gly Arg 
1               5                   10                  15      
Thr Ile Ile Met Ser Thr His His Met Asp Glu Ala Asp Leu Leu Gly 
            20                  25                  30          
Asp Arg Ile Ala Ile Ile Ala Gln Gly Arg Leu Tyr Cys Ser Gly Thr 
        35                  40                  45              
Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu 
    50                  55                  60                  
Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu Gly 
65                  70                  75                  80  
Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala His 
                85                  90                  95      
Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu 
            100                 105                 110         
Leu Met Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu 
        115                 120                 125             
Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys 
    130                 135                 140                 
His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala 
145                 150                 155                 160 
Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu 
                165                 170                 175     
Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala 
            180                 185                 190         
Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys 
        195                 200                 205             
Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val 
    210                 215                 220                 
Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro 
225                 230                 235                 240 
Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val 
                245                 250                 255     
Leu Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile 
            260                 265                 270         
Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe 
        275                 280                 285             
Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu 
    290                 295                 300                 
Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr 
305                 310                 315                 320 
Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala 
                325                 330                 335     
Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu 
            340                 345                 350         
Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr 
        355                 360                 365             
Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp 
    370                 375                 380                 
Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys 
385                 390                 395                 400 
Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro 
                405                 410                 415     
Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp 
            420                 425                 430         
Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg 
        435                 440                 445             
Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly 
    450                 455                 460                 
Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala 
465                 470                 475                 480 
Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly 
                485                 490                 495     
Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys 
            500                 505                 510         
His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly 
        515                 520                 525             
Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu 
    530                 535                 540                 
Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr 
545                 550                 555                 560 
Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile 
                565                 570                 575     
Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile 
            580                 585                 590         
Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln 
        595                 600                 605             
Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser 
    610                 615                 620                 
Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr 
625                 630                 635                 640 
Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys 
                645                 650                 655     
Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu 
            660                 665                 670         
Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe 
        675                 680                 685             
Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn 
    690                 695                 700                 
Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu 
705                 710                 715                 720 
Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys 
                725                 730                 735     
Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp 
            740                 745                 750         
Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu 
        755                 760                 765             
Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu 
    770                 775                 780                 
Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu 
785                 790                 795                 800 
Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys 
                805                 810                 815     
Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg 
            820                 825                 830         
Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu 
        835                 840                 845             
Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys 
    850                 855                 860                 
Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly 
865                 870                 875                 880 
Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val 
                885                 890                 895     
Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile 
            900                 905                 910         
Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile 
        915                 920                 925             
Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu 
    930                 935                 940                 
Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile 
945                 950                 955                 960 
Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr 
                965                 970                 975     
Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly 
            980                 985                 990         
Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro 
        995                 1000                1005            
Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu 
    1010                1015                1020                
Gly Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala 
1025                1030                1035                1040
Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met 
                1045                1050                1055    
Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val 
            1060                1065                1070        
Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn 
        1075                1080                1085            
Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg 
    1090                1095                1100                
Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu 
1105                1110                1115                1120
Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile 
                1125                1130                1135    
Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn 
            1140                1145                1150        
Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg 
        1155                1160                1165            
Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
    1170                1175            

<210> 97
<211> 1184
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4N-1185

<400> 97
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                



<210> 98
<211> 1089
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4C-1185

<400> 98
Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val 
1               5                   10                  15      
Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val 
            20                  25                  30          
Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu 
        35                  40                  45              
Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg 
    50                  55                  60                  
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile 
65                  70                  75                  80  
Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser 
                85                  90                  95      
Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn 
            100                 105                 110         
Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln 
        115                 120                 125             
Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His 
    130                 135                 140                 
Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu 
145                 150                 155                 160 
Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val 
                165                 170                 175     
Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln 
            180                 185                 190         
Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile 
        195                 200                 205             
Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp 
    210                 215                 220                 
Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser 
225                 230                 235                 240 
Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe 
                245                 250                 255     
Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly 
            260                 265                 270         
Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln 
        275                 280                 285             
Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys 
    290                 295                 300                 
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu 
305                 310                 315                 320 
Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu 
                325                 330                 335     
Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys 
            340                 345                 350         
Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val 
        355                 360                 365             
Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val 
    370                 375                 380                 
Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly 
385                 390                 395                 400 
Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys 
                405                 410                 415     
Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys 
            420                 425                 430         
Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn 
        435                 440                 445             
Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser 
    450                 455                 460                 
Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr 
465                 470                 475                 480 
Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala 
                485                 490                 495     
Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser 
            500                 505                 510         
Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu 
        515                 520                 525             
Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe 
    530                 535                 540                 
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly 
545                 550                 555                 560 
Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu 
                565                 570                 575     
Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro 
            580                 585                 590         
Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr 
        595                 600                 605             
Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala 
    610                 615                 620                 
Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg 
625                 630                 635                 640 
Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys 
                645                 650                 655     
Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp 
            660                 665                 670         
Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp 
        675                 680                 685             
Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val 
    690                 695                 700                 
Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln 
705                 710                 715                 720 
Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp 
                725                 730                 735     
Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp 
            740                 745                 750         
Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser 
        755                 760                 765             
Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe 
    770                 775                 780                 
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met 
785                 790                 795                 800 
Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly 
                805                 810                 815     
Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr 
            820                 825                 830         
Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His 
        835                 840                 845             
Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu 
    850                 855                 860                 
Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala 
865                 870                 875                 880 
Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser 
                885                 890                 895     
Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu 
            900                 905                 910         
Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val 
        915                 920                 925             
Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His 
    930                 935                 940                 
Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val 
945                 950                 955                 960 
Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys 
                965                 970                 975     
Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp 
            980                 985                 990         
Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn 
        995                 1000                1005            
Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe 
    1010                1015                1020                
Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser 
1025                1030                1035                1040
His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr 
                1045                1050                1055    
Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His 
            1060                1065                1070        
Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln 
        1075                1080                1085            
Asp 
    

<210> 99
<211> 1183
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1096-gp41N

<400> 99
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Cys Leu Asp Leu Lys Thr Gln Val Gln 
    1090                1095                1100                
Thr Pro Gln Gly Met Lys Glu Ile Ser Asn Ile Gln Val Gly Asp Leu 
1105                1110                1115                1120
Val Leu Ser Asn Thr Gly Tyr Asn Glu Val Leu Asn Val Phe Pro Lys 
                1125                1130                1135    
Ser Lys Lys Lys Ser Tyr Lys Ile Thr Leu Glu Asp Gly Lys Glu Ile 
            1140                1145                1150        
Ile Cys Ser Glu Glu His Leu Phe Pro Thr Gln Thr Gly Glu Met Asn 
        1155                1160                1165            
Ile Ser Gly Gly Leu Lys Glu Gly Met Cys Leu Tyr Val Lys Glu 
    1170                1175                1180            

<210> 100
<211> 1215
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1096-gp41C

<400> 100
Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      
Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          
Ile Leu Thr His Asn Ser Arg Arg Ser Ile Trp Asp Leu Leu Leu Lys 
        35                  40                  45              
Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met Asp Glu 
    50                  55                  60                  
Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly Arg Leu 
65                  70                  75                  80  
Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly 
                85                  90                  95      
Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg 
            100                 105                 110         
Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr 
        115                 120                 125             
Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val Leu Asp 
    130                 135                 140                 
Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val Pro Glu 
145                 150                 155                 160 
Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro 
                165                 170                 175     
Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu 
            180                 185                 190         
Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp 
        195                 200                 205             
Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser Asp Ser 
    210                 215                 220                 
Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn Val Asn 
225                 230                 235                 240 
Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro 
                245                 250                 255     
Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His Pro Glu 
            260                 265                 270         
Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr 
        275                 280                 285             
Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val Lys Arg 
    290                 295                 300                 
Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln Ile Val 
305                 310                 315                 320 
Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile 
                325                 330                 335     
Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr 
            340                 345                 350         
Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln 
        355                 360                 365             
Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn 
    370                 375                 380                 
Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser 
385                 390                 395                 400 
Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe 
                405                 410                 415     
Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys 
            420                 425                 430         
Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala 
        435                 440                 445             
Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu 
    450                 455                 460                 
Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr 
465                 470                 475                 480 
Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu 
                485                 490                 495     
Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro 
            500                 505                 510         
Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile 
        515                 520                 525             
Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile 
    530                 535                 540                 
Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp 
545                 550                 555                 560 
Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala 
                565                 570                 575     
His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu 
            580                 585                 590         
Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu 
        595                 600                 605             
Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val 
    610                 615                 620                 
Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val 
625                 630                 635                 640 
Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe 
                645                 650                 655     
Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp 
            660                 665                 670         
Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe 
        675                 680                 685             
Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala 
    690                 695                 700                 
Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met 
705                 710                 715                 720 
Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala 
                725                 730                 735     
Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr 
            740                 745                 750         
Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn 
        755                 760                 765             
Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly 
    770                 775                 780                 
Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr 
785                 790                 795                 800 
Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu 
                805                 810                 815     
Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe 
            820                 825                 830         
Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile 
        835                 840                 845             
Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala 
    850                 855                 860                 
Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu 
865                 870                 875                 880 
Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala 
                885                 890                 895     
Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu 
            900                 905                 910         
Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr 
        915                 920                 925             
Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser 
    930                 935                 940                 
Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro 
945                 950                 955                 960 
Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr 
                965                 970                 975     
Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val 
            980                 985                 990         
Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys 
        995                 1000                1005            
Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala 
    1010                1015                1020                
Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr 
1025                1030                1035                1040
Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val 
                1045                1050                1055    
Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met 
            1060                1065                1070        
Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Lys Gly 
        1075                1080                1085            
Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys Phe Gly 
    1090                1095                1100                
Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp Asp Leu 
1105                1110                1115                1120
Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro 
                1125                1130                1135    
Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe Gln Val 
            1140                1145                1150        
Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser His Lys 
        1155                1160                1165            
Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr Leu Asp 
    1170                1175                1180                
Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His Asp Leu 
1185                1190                1195                1200
Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln Asp 
                1205                1210                1215

<210> 101
<211> 1272
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1185-gp41N

<400> 101
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly Met Lys Glu 
1185                1190                1195                1200
Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn Thr Gly Tyr 
                1205                1210                1215    
Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys Ser Tyr Lys 
            1220                1225                1230        
Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu His Leu 
        1235                1240                1245            
Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly Leu Lys Glu 
    1250                1255                1260                
Gly Met Cys Leu Tyr Val Lys Glu 
1265                1270        

<210> 102
<211> 1126
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4-1185-gp41C

<400> 102
Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      
Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          
Ile Leu Thr His Asn Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu 
        35                  40                  45              
Thr Pro Glu Gln Val Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val 
    50                  55                  60                  
Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln 
65                  70                  75                  80  
Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr 
                85                  90                  95      
Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu 
            100                 105                 110         
Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys 
        115                 120                 125             
Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln 
    130                 135                 140                 
Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg 
145                 150                 155                 160 
Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly 
                165                 170                 175     
Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys 
            180                 185                 190         
Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln His Val 
        195                 200                 205             
Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg Ser His Lys 
    210                 215                 220                 
Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala 
225                 230                 235                 240 
Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu 
                245                 250                 255     
Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met 
            260                 265                 270         
Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu 
        275                 280                 285             
Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro 
    290                 295                 300                 
Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser 
305                 310                 315                 320 
Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn 
                325                 330                 335     
Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu 
            340                 345                 350         
Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr 
        355                 360                 365             
Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser 
    370                 375                 380                 
Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys 
385                 390                 395                 400 
Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly 
                405                 410                 415     
Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe 
            420                 425                 430         
Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr 
        435                 440                 445             
Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr 
    450                 455                 460                 
Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu 
465                 470                 475                 480 
Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu 
                485                 490                 495     
Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln 
            500                 505                 510         
Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr 
        515                 520                 525             
Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser 
    530                 535                 540                 
Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn 
545                 550                 555                 560 
Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr 
                565                 570                 575     
Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala 
            580                 585                 590         
Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr 
        595                 600                 605             
Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly 
    610                 615                 620                 
Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val 
625                 630                 635                 640 
Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly 
                645                 650                 655     
Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn 
            660                 665                 670         
Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val 
        675                 680                 685             
Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser 
    690                 695                 700                 
Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala 
705                 710                 715                 720 
Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val 
                725                 730                 735     
Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His 
            740                 745                 750         
Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val 
        755                 760                 765             
Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly 
    770                 775                 780                 
Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr 
785                 790                 795                 800 
Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg 
                805                 810                 815     
Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr 
            820                 825                 830         
Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp 
        835                 840                 845             
Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His 
    850                 855                 860                 
Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu 
865                 870                 875                 880 
Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro 
                885                 890                 895     
Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly 
            900                 905                 910         
Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn 
        915                 920                 925             
Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu 
    930                 935                 940                 
Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg 
945                 950                 955                 960 
Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val 
                965                 970                 975     
Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg 
            980                 985                 990         
Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln 
        995                 1000                1005            
His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile 
    1010                1015                1020                
Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln 
1025                1030                1035                1040
Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr 
                1045                1050                1055    
Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe 
            1060                1065                1070        
Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser 
        1075                1080                1085            
Val Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln 
    1090                1095                1100                
Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala 
1105                1110                1115                1120
Ser Arg Gln Ala Gln Asp 
                1125    

<210> 103
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> 3FT

<400> 103
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      
Lys Asp Asp Asp Asp Lys 
            20          

<210> 104
<211> 37
<212> PRT
<213> Artificial Sequence


<220> 
<223> GP41C

<400> 104
Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      
Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          
Ile Leu Thr His Asn 
        35          

<210> 105
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> ConC

<400> 105
Met Val Lys Ile Ile Ser Arg Gln Ser Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      
Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Ala Asn Gly Leu 
            20                  25                  30          
Ile Ala Ser Asn 
        35      

<210> 106
<211> 2273
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABCA4

<400> 106
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val 
1185                1190                1195                1200
Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val 
                1205                1210                1215    
Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu 
            1220                1225                1230        
Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg 
        1235                1240                1245            
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile 
    1250                1255                1260                
Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser 
1265                1270                1275                1280
Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn 
                1285                1290                1295    
Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln 
            1300                1305                1310        
Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His 
        1315                1320                1325            
Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu 
    1330                1335                1340                
Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val 
1345                1350                1355                1360
Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln 
                1365                1370                1375    
Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile 
            1380                1385                1390        
Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp 
        1395                1400                1405            
Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser 
    1410                1415                1420                
Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe 
1425                1430                1435                1440
Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly 
                1445                1450                1455    
Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln 
            1460                1465                1470        
Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys 
        1475                1480                1485            
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu 
    1490                1495                1500                
Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu 
1505                1510                1515                1520
Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys 
                1525                1530                1535    
Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val 
            1540                1545                1550        
Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val 
        1555                1560                1565            
Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly 
    1570                1575                1580                
Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys 
1585                1590                1595                1600
Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys 
                1605                1610                1615    
Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn 
            1620                1625                1630        
Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser 
        1635                1640                1645            
Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr 
    1650                1655                1660                
Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala 
1665                1670                1675                1680
Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser 
                1685                1690                1695    
Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu 
            1700                1705                1710        
Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe 
        1715                1720                1725            
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly 
    1730                1735                1740                
Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu 
1745                1750                1755                1760
Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro 
                1765                1770                1775    
Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr 
            1780                1785                1790        
Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala 
        1795                1800                1805            
Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg 
    1810                1815                1820                
Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys 
1825                1830                1835                1840
Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp 
                1845                1850                1855    
Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp 
            1860                1865                1870        
Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val 
        1875                1880                1885            
Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln 
    1890                1895                1900                
Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp 
1905                1910                1915                1920
Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp 
                1925                1930                1935    
Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser 
            1940                1945                1950        
Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe 
        1955                1960                1965            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met 
    1970                1975                1980                
Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly 
1985                1990                1995                2000
Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr 
                2005                2010                2015    
Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His 
            2020                2025                2030        
Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu 
        2035                2040                2045            
Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala 
    2050                2055                2060                
Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser 
2065                2070                2075                2080
Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu 
                2085                2090                2095    
Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val 
            2100                2105                2110        
Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His 
        2115                2120                2125            
Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val 
    2130                2135                2140                
Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys 
2145                2150                2155                2160
Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp 
                2165                2170                2175    
Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn 
            2180                2185                2190        
Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe 
        2195                2200                2205            
Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser 
    2210                2215                2220                
His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr 
2225                2230                2235                2240
Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His 
                2245                2250                2255    
Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln 
            2260                2265                2270        
Asp 
    

<210> 107
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> T2

<400> 107
Lys Leu Lys Gly Leu Gly Lys Arg Cys Lys Arg Arg Glu Asp Leu Glu 
1               5                   10                  15      
Ile Arg Phe Ile Leu 
            20      

<210> 108
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> T3

<400> 108
Trp Lys Leu Leu Leu Trp Val Gly Leu Val Leu Val Leu Lys His His 
1               5                   10                  15      
Asp Gly Ala Ala His 
            20      

