                         SEQUENCE LISTING

<110>  MeiraGTx UK II Limited
       Xuecui, Guo
       Alexandria, Forbes
       Kevin G., Liu
       Ji-In, Kim
 
<120>  APTAMERS THAT BIND THIAMINE ANALOGS AND DERIVATIVES

<130>  162027.48976

<140>  US 62/994,135
<141>  2020-03-24

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is C or no nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is T or no nucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is C, G, or T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is A or T

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is C or T

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is C or T

<400>  1
acnggggtcc ggcntnttca tttggcnccg gtgagannan acccttnnnn cctgttnacg       60

gataatgccg cngcagggag t                                                 81


<210>  2
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is C or no nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is T or no nucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is G or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is C or T

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is C or T

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is G or T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is A, G, or T

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is A or T

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is C or T

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is C or T

<400>  2
acnggggtcc ggcntnttca tttggcgccg gtgagannan acccttnnnn cctgttnacg       60

gataatgccg cngcagggag t                                                 81


<210>  3
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is C or T

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is C or T

<400>  3
acaggggtcc ggccttttca tttggcgccg gtgagagcac accctttgaa cctgttnacg       60

gataatgccg cngcagggag t                                                 81


<210>  4
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is G or T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is A, G, or T

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is A or T

<400>  4
acnggggtcc ggccttttca tttggcgccg gtgagagcac acccttnnnn cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  5
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is G or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is C or T

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is C or T

<400>  5
acaggggtcc ggccttttca tttggcgccg gtgagannan accctttgaa cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  6
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is C or G

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is a, c, g, or t

<400>  6
acaggggtcc ggccttttca tttggcnccg gtgagannan acccttnnna cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  7
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14G4

<400>  7
acaggggtcc ggccttttca tttggcgccg gtgagagcac accctttgaa cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  8
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1D10

<400>  8
acaggggtcc ggccttttca tttggcgccg gtgagattat accctttgaa cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  9
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3H4

<400>  9
acaggggtcc ggccttttca tttggcgccg gtgagagcac accctttgaa cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  10
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F10

<400>  10
acgggggtcc ggccttttca tttggcgccg gtgagagcac acccttcgga cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  11
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3H9

<400>  11
acaggggtcc ggcttttcat ttggcgccgg tgagagcaca cccttatgac ctgtttacgg       60

ataatgccgc cgcagggagt                                                   80


<210>  12
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G2

<400>  12
acgggggtcc ggccttttca tttggcgccg gtgagagcac accctttgga cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  13
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6D2

<400>  13
acgggggtcc ggccttttca tttggcgccg gtgagagcac accctttgtt cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  14
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6B4

<400>  14
acaggggtcc ggccttttca tttggcgccg gtgagagcac acccttgtga cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  15
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4H2

<400>  15
acaggggtcc ggccttttca tttggcgccg gtgagagcac acccttcgga cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  16
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6C4

<400>  16
acgggggtcc ggccttttca tttggcgccg gtgagagcac acccttcgaa cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  17
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6G12

<400>  17
acaggggtcc ggccttttca tttggcgccg gtgagagcac accctttgga cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  18
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8F1

<400>  18
acgggggtcc ggcctttcat ttggcgccgg tgagagcaca cccttcggac ctgtttacgg       60

ataatgccgc cgcagggagt                                                   80


<210>  19
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10A7

<400>  19
acaggggtcc ggccttttca tttggcgccg gtgagatgat accctttgga cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  20
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12D5

<400>  20
acaggggtcc ggccttttca tttggcgccg gtgagagcac accctttgga cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  21
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12G7

<400>  21
acaggggtcc ggccttttca tttggcgccg gtgagattat acccttcgga cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  22
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12H3

<400>  22
acaggggtcc ggccttttca tttggcgccg gtgagatcac acccttacta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  23
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13H7

<400>  23
acaggggtcc ggccttttca tttggcgccg gtgagaacag accctttgca cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  24
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13B6

<400>  24
acaggggtcc ggccttttca tttggcgccg gtgagaacac accctttgta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  25
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15A5

<400>  25
acaggggtcc ggccttttca tttggcgccg gtgagattat acccttacta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  26
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D10

<400>  26
acaggggtcc ggccttttca tttggcaccg gtgagaacat acccttcgga cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  27
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15F9

<400>  27
acaggggtcc ggccttttca tttggcgccg gtgagattac acccttagca cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  28
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16E5

<400>  28
acaggggtcc ggccttttca tttggcgccg gtgagatcaa acccttggca cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  29
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16G8

<400>  29
acaggggtcc ggccttttca tttggcgccg gtgagagtac acccttcgca cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  30
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16G6

<400>  30
acaggggtcc ggccttttca tttggcgccg gtgagatcac acccttggta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  31
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17E2

<400>  31
acaggggtcc ggccttttca tttggcgccg gtgagattac accctttgga cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  32
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17G1

<400>  32
acaggggtcc ggccttttca tttggcgccg gtgagatcac acccttggaa cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  33
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17D3

<400>  33
acaggggtcc ggccttttca tttggcgccg gtgagaggat acccttcgga cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  34
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17F5

<400>  34
acaggggtcc ggccttttca tttggcgccg gtgagagtat acccttagta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  35
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17G3

<400>  35
acaggggtcc ggccttttca tttggcaccg gtgagacaat acccttggta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  36
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  18G9

<400>  36
acaggggtcc ggccttttca tttggcgccg gtgagagaat acccttggta cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  37
<211>  563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G17 riboswitch


<220>
<221>  misc_feature
<222>  (317)..(317)
<223>  n is aptamer encoding sequence

<400>  37
gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240

ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300

cagtagaagg taatgtnaca ttacgcacca ttctaaagaa taacagtgat aatttctggg      360

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt      420

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttat      480

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcatgttca      540

tacctcttat cttcctccca cag                                              563


<210>  38
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  14G4 with P1 stem

<400>  38
guaauguaca gggguccggc cuuuucauuu ggcgccggug agagcacacc cuuugaaccu       60

guuuacggau aaugccgccg cagggaguac auuac                                  95


<210>  39
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library A1


<220>
<221>  misc_feature
<222>  (55)..(57)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (70)..(71)
<223>  n is a, c, g, or t

<400>  39
acaggggtcc ggccttttca tttggcgccg gtgagagcac accctttgaa cctgnnncgg       60

ataatgccgn ngcagggagt                                                   80


<210>  40
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library A2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (46)..(50)
<223>  n is a, c, g, or t

<400>  40
acnggggtcc ggccttttca tttggcgccg gtgagagcac accctnnnnn cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  41
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library A3


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (37)..(41)
<223>  n is a, c, g, or t

<400>  41
acaggggncc ggccttttca tttggcgccg gtgagannnn nccctttgaa cctgtttacg       60

gataatgccg ccgcagggag t                                                 81


<210>  42
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library A4


<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(49)
<223>  n is a, c, g, or t

<400>  42
acaggggtcc ggccttttca tttggcgccg gtgagannan acccttnnna cctgttcacg       60

gataatgccg ctgcagggag t                                                 81


<210>  43
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is C or no nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is U or no nucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is C, G, or U

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is A or U

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is C or U

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is C or U

<400>  43
acnggggucc ggcnunuuca uuuggcnccg gugagannan acccuunnnn ccuguunacg       60

gauaaugccg cngcagggag u                                                 81


<210>  44
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is C or no nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is U or no nucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is G or U

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is C or U

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is C or U

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is G or U

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is A, G, or U

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is A or U

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is C or U

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is C or U

<400>  44
acnggggucc ggcnunuuca uuuggcgccg gugagannan acccuunnnn ccuguunacg       60

gauaaugccg cngcagggag u                                                 81


<210>  45
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  n is C or U

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is C or U

<400>  45
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuugaa ccuguunacg       60

gauaaugccg cngcagggag u                                                 81


<210>  46
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is G or U

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is A, G, or U

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is A or U

<400>  46
acnggggucc ggccuuuuca uuuggcgccg gugagagcac acccuunnnn ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  47
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is G or U

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is C or U

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is C or U

<400>  47
acaggggucc ggccuuuuca uuuggcgccg gugagannan acccuuugaa ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  48
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer motif


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is A or G

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is C or G

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is a, c, g, or u

<400>  48
acaggggucc ggccuuuuca uuuggcnccg gugagannan acccuunnna ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  49
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  14G4

<400>  49
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuugaa ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  50
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1D10

<400>  50
acaggggucc ggccuuuuca uuuggcgccg gugagauuau acccuuugaa ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  51
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3H4

<400>  51
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuugaa ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  52
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3F10

<400>  52
acgggggucc ggccuuuuca uuuggcgccg gugagagcac acccuucgga ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  53
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3H9

<400>  53
acaggggucc ggcuuuucau uuggcgccgg ugagagcaca cccuuaugac cuguuuacgg       60

auaaugccgc cgcagggagu                                                   80


<210>  54
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  4G2

<400>  54
acgggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuugga ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  55
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  6D2

<400>  55
acgggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuuguu ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  56
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  6B4

<400>  56
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuguga ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  57
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  4H2

<400>  57
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuucgga ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  58
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  6C4

<400>  58
acgggggucc ggccuuuuca uuuggcgccg gugagagcac acccuucgaa ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  59
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  6G12

<400>  59
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuugga ccuguuuacg       60

gauaaugccg ccgcagggag u                                                 81


<210>  60
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  8F1

<400>  60
acgggggucc ggccuuucau uuggcgccgg ugagagcaca cccuucggac cuguuuacgg       60

auaaugccgc cgcagggagu                                                   80


<210>  61
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  10A7

<400>  61
acaggggucc ggccuuuuca uuuggcgccg gugagaugau acccuuugga ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  62
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  12D5

<400>  62
acaggggucc ggccuuuuca uuuggcgccg gugagagcac acccuuugga ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  63
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  12G7

<400>  63
acaggggucc ggccuuuuca uuuggcgccg gugagauuau acccuucgga ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  64
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  12H3

<400>  64
acaggggucc ggccuuuuca uuuggcgccg gugagaucac acccuuacua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  65
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  13H7

<400>  65
acaggggucc ggccuuuuca uuuggcgccg gugagaacag acccuuugca ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  66
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  13B6

<400>  66
acaggggucc ggccuuuuca uuuggcgccg gugagaacac acccuuugua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  67
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  15A5

<400>  67
acaggggucc ggccuuuuca uuuggcgccg gugagauuau acccuuacua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  68
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  15D10

<400>  68
acaggggucc ggccuuuuca uuuggcaccg gugagaacau acccuucgga ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  69
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  15F9

<400>  69
acaggggucc ggccuuuuca uuuggcgccg gugagauuac acccuuagca ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  70
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  16E5

<400>  70
acaggggucc ggccuuuuca uuuggcgccg gugagaucaa acccuuggca ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  71
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  16G8

<400>  71
acaggggucc ggccuuuuca uuuggcgccg gugagaguac acccuucgca ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  72
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  16G6

<400>  72
acaggggucc ggccuuuuca uuuggcgccg gugagaucac acccuuggua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  73
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17E2

<400>  73
acaggggucc ggccuuuuca uuuggcgccg gugagauuac acccuuugga ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  74
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17G1

<400>  74
acaggggucc ggccuuuuca uuuggcgccg gugagaucac acccuuggaa ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  75
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17D3

<400>  75
acaggggucc ggccuuuuca uuuggcgccg gugagaggau acccuucgga ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  76
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17F5

<400>  76
acaggggucc ggccuuuuca uuuggcgccg gugagaguau acccuuagua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  77
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  17G3

<400>  77
acaggggucc ggccuuuuca uuuggcaccg gugagacaau acccuuggua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  78
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  18G9

<400>  78
acaggggucc ggccuuuuca uuuggcgccg gugagagaau acccuuggua ccuguucacg       60

gauaaugccg cugcagggag u                                                 81


<210>  79
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified DHFR exon 2

<400>  79
gaatgaattc agatatttcc agagaatgaa aaaaaaatct tcagtagaag                  50


<210>  80
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1 snRNP binding site (consensus site)

<400>  80
caggtaagta                                                              10


<210>  81
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  U1 snRNP binding site (consensus site)

<400>  81
cagguaagua                                                              10


<210>  82
<211>  2305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPPz riboswitch

<400>  82
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gccgagtaac gctgtttctc     1260

taacttgtag gaatgaattc agatatttcc agagaatgaa aaaaaaatct tcagtagaag     1320

gtaatgtgtc ggagtgcctt agggattatt cccctaaagc tgagaccgca ttgcgggatc     1380

cgttgaacct gatcaggcta atacctgcga agggaacaca ttacgcacca ttctaaagaa     1440

taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc     1500

atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta     1560

ccattctgct tttattttat ggttgggata aggctggatt attctgagtc caagctaggc     1620

ccttttgcta atcatgttca tacctcttat cttcctccca cagcaaggat atgggctcac     1680

tgagactaca tcagctattc tgattacacc cgagggggat gataaaccgg gcgcggtcgg     1740

taaagttgtt ccattttttg aagcgaaggt tgtggatctg gataccggga aaacgctggg     1800

cgttaatcaa agaggcgaac tgtgtgtgag aggtcctatg attatgtccg gttatgtaaa     1860

caatccggaa gcgaccaacg ccttgattga caaggatgga tggctacatt ctggagacat     1920

agcttactgg gacgaagacg aacacttctt catcgttgac cgcctgaagt ctctgattaa     1980

gtacaaaggc tatcaggtgg ctcccgctga attggaatcc atcttgctcc aacaccccaa     2040

catcttcgac gcaggtgtcg caggtcttcc cgacgatgac gccggtgaac ttcccgccgc     2100

cgttgttgtt ttggagcacg gaaagacgat gacggaaaaa gagatcgtgg attacgtcgc     2160

cagtcaagta acaaccgcga aaaagttgcg cggaggagtt gtgtttgtgg acgaagtacc     2220

gaaaggtctt accggaaaac tcgacgcaag aaaaatcaga gagatcctca taaaggccaa     2280

gaagggcgga aagatcgccg tgtaa                                           2305


<210>  83
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPPm riboswitch

<400>  83
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gccgagtaac gctgtttctc     1260

taacttgtag gaatgaattc agatatttcc agagaatgaa aaaaaaatct tcagtagaag     1320

gtaatgtctc ggggtgccct tctgcgtgaa ggctgagaaa tacccgtatc acctgatctg     1380

gataatgcca gcgtagggaa gacattacgc accattctaa agaataacag tgataatttc     1440

tgggttaagg caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg     1500

atgtaagagg tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt     1560

ttatggttgg gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg     1620

ttcatacctc ttatcttcct cccacagcaa ggatatgggc tcactgagac tacatcagct     1680

attctgatta cacccgaggg ggatgataaa ccgggcgcgg tcggtaaagt tgttccattt     1740

tttgaagcga aggttgtgga tctggatacc gggaaaacgc tgggcgttaa tcaaagaggc     1800

gaactgtgtg tgagaggtcc tatgattatg tccggttatg taaacaatcc ggaagcgacc     1860

aacgccttga ttgacaagga tggatggcta cattctggag acatagctta ctgggacgaa     1920

gacgaacact tcttcatcgt tgaccgcctg aagtctctga ttaagtacaa aggctatcag     1980

gtggctcccg ctgaattgga atccatcttg ctccaacacc ccaacatctt cgacgcaggt     2040

gtcgcaggtc ttcccgacga tgacgccggt gaacttcccg ccgccgttgt tgttttggag     2100

cacggaaaga cgatgacgga aaaagagatc gtggattacg tcgccagtca agtaacaacc     2160

gcgaaaaagt tgcgcggagg agttgtgttt gtggacgaag taccgaaagg tcttaccgga     2220

aaactcgacg caagaaaaat cagagagatc ctcataaagg ccaagaaggg cggaaagatc     2280

gccgtgtaa                                                             2289


<210>  84
<211>  2296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14G4 riboswitch

<400>  84
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gccgagtaac gctgtttctc     1260

taacttgtag gaatgaattc agatatttcc agagaatgaa aaaaaaatct tcagtagaag     1320

gtaatgtaca ggggtccggc cttttcattt ggcgccggtg agagcacacc ctttgaacct     1380

gtttacggat aatgccgccg cagggagtac attacgcacc attctaaaga ataacagtga     1440

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1500

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1560

ttttatttta tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1620

aatcatgttc atacctctta tcttcctccc acagcaagga tatgggctca ctgagactac     1680

atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg gtaaagttgt     1740

tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg gcgttaatca     1800

aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa acaatccgga     1860

agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca tagcttactg     1920

ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta agtacaaagg     1980

ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca acatcttcga     2040

cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg ccgttgttgt     2100

tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg ccagtcaagt     2160

aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac cgaaaggtct     2220

taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca agaagggcgg     2280

aaagatcgcc gtgtaa                                                     2296


<210>  85
<211>  579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Con8-Epo

<400>  85
atgggggtgc ccgaacgtcc caccctgctg cttttactct ccttgctact gattcctctg       60

ggcctcccag tcctctgtgc tcccccacgc ctcatctgcg acagtcgagt tctggagagg      120

tacatcttag aggccaagga ggcagaaaat gtcacgatgg gttgtgcaga aggtcccaga      180

ctgagtgaaa atattacagt cccagatacc aaagtcaact tctatgcttg gaaaagaatg      240

gaggtggaag aacaggccat agaagtttgg caaggcctgt ccctgctctc agaagccatc      300

ctgcaggccc aggccctgct agccaattcc tcccagccac cagagaccct tcagcttcat      360

atagacaaag ccatcagtgg tctacgtagc ctcacttcac tgcttcgggt actgggagct      420

cagaaggaat tgatgtcgcc tccagatacc accccacctg ctccactccg aacactcaca      480

gtggatactt tctgcaagct cttccgggtc tacgccaact tcctccgggg gaaactgaag      540

ctgtacacgg gagaggtctg caggagaggg gacaggtga                             579


<210>  86
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epo-3H4

<400>  86
atgggggtgc ccgaacgtcc caccctgctg cttttactct ccttgctact gattcctctg       60

ggcctcccag tcctctgtgc tcccccacgc ctcatctgcg acagtcgagt tctggagagg      120

tacatcttag aggccaagga ggcagaaaat gtcacgatgg gttgtgcaga aggtcccaga      180

ctgagtgaaa atattacagt cccagatacc aaagtcaact tctatgcttg gaaaagaatg      240

gaggtggaag aacaggccat agaagtttgg caaggcctgt ccctgctctc agaagccatc      300

ctgcagggtg agtctatggg acccttgatg ttttctttcc ccttcttttc tatggttaag      360

ttcatgtcat aggaagggga gaagtaacag ggtacacata ttgaccaaat cagggtaatt      420

ttgcatttgt aattttaaaa aatgctttct tcttttaata tacttttttg tttatcttat      480

ttctaatact ttccctaatc tctttctttc agggcaataa tgatacaatg tatcatgccg      540

agtaacgctg tttctctaac ttgtaggaat gaattcagat atttccagag aatgaaaaaa      600

aatcttcagt agaaggtaat gtacaggggt ccggcctttt catttggcgc cggtgagagc      660

acaccctttg aacctgttca cggataatgc cgctgcaggg agtacattac gcaccattct      720

aaagaataac agtgataatt tctgggttaa ggcaatagca atatttctgc atataaatat      780

ttctgcatat aaattgtaac tgatgtaaga ggtttcatat tgctaatagc agctacaatc      840

cagctaccat tctgctttta ttttatggtt gggataaggc tggattattc tgagtccaag      900

ctaggccctt ttgctaatca tgttcatacc tcttatcttc ctcccacagc ccaggccctg      960

ctagccaatt cctcccagcc accagagacc cttcagcttc atatagacaa agccatcagt     1020

ggtctacgta gcctcacttc actgcttcgg gtactgggag ctcagaagga attgatgtcg     1080

cctccagata ccaccccacc tgctccactc cgaacactca cagtggatac tttctgcaag     1140

ctcttccggg tctacgccaa cttcctccgg gggaaactga agctgtacac gggagaggtc     1200

tgcaggagag gggacaggtg a                                               1221


<210>  87
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epo-15D10

<400>  87
atgggggtgc ccgaacgtcc caccctgctg cttttactct ccttgctact gattcctctg       60

ggcctcccag tcctctgtgc tcccccacgc ctcatctgcg acagtcgagt tctggagagg      120

tacatcttag aggccaagga ggcagaaaat gtcacgatgg gttgtgcaga aggtcccaga      180

ctgagtgaaa atattacagt cccagatacc aaagtcaact tctatgcttg gaaaagaatg      240

gaggtggaag aacaggccat agaagtttgg caaggcctgt ccctgctctc agaagccatc      300

ctgcagggtg agtctatggg acccttgatg ttttctttcc ccttcttttc tatggttaag      360

ttcatgtcat aggaagggga gaagtaacag ggtacacata ttgaccaaat cagggtaatt      420

ttgcatttgt aattttaaaa aatgctttct tcttttaata tacttttttg tttatcttat      480

ttctaatact ttccctaatc tctttctttc agggcaataa tgatacaatg tatcatgccg      540

agtaacgctg tttctctaac ttgtaggaat gaattcagat atttccagag aatgaaaaaa      600

aatcttcagt agaaggtaat gtacaggggt ccggcctttt catttggcac cggtgagaac      660

atacccttcg gacctgttca cggataatgc cgctgcaggg agtacattac gcaccattct      720

aaagaataac agtgataatt tctgggttaa ggcaatagca atatttctgc atataaatat      780

ttctgcatat aaattgtaac tgatgtaaga ggtttcatat tgctaatagc agctacaatc      840

cagctaccat tctgctttta ttttatggtt gggataaggc tggattattc tgagtccaag      900

ctaggccctt ttgctaatca tgttcatacc tcttatcttc ctcccacagc ccaggccctg      960

ctagccaatt cctcccagcc accagagacc cttcagcttc atatagacaa agccatcagt     1020

ggtctacgta gcctcacttc actgcttcgg gtactgggag ctcagaagga attgatgtcg     1080

cctccagata ccaccccacc tgctccactc cgaacactca cagtggatac tttctgcaag     1140

ctcttccggg tctacgccaa cttcctccgg gggaaactga agctgtacac gggagaggtc     1200

tgcaggagag gggacaggtg a                                               1221


<210>  88
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFP-6B4

<400>  88
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaagggtgag tctatgggac ccttgatgtt      300

ttctttcccc ttcttttcta tggttaagtt catgtcatag gaaggggaga agtaacaggg      360

tacacatatt gaccaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc      420

ttttaatata cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag      480

ggcaataatg atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga      540

attcagatat ttccagagaa tgaaaaaaaa tcttcagtag aaggtaatgt acaggggtcc      600

ggccttttca tttggcgccg gtgagagcac acccttgtga cctgtttacg gataatgccg      660

ccgcagggag tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      720

caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg      780

tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt ttatggttgg      840

gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc      900

ttatcttcct cccacagcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac      960

tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg     1020

aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac     1080

aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc     1140

aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac     1200

acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc     1260

gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc     1320

gccgccggga tcactctcgg catggacgag ctgtacaagt aa                        1362


<210>  89
<211>  1055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epo-Con1

<400>  89
atgggggtgc ccgaacgtcc caccctgctg cttttactct ccttgctact gattcctctg       60

ggcctcccag tcctctgtgc tcccccacgc ctcatctgcg acagtcgagt tctggagagg      120

tacatcttag aggccaagga ggcagaaaat gtcacgatgg gttgtgcaga aggtcccaga      180

ctgagtgaaa atattacagt cccagatacc aaagtcaact tctatgcttg gaaaagaatg      240

gaggtggaag aacaggccat agaagtttgg caaggcctgt ccctgctctc agaagccatc      300

ctgcagggtg agtctatggg acccttgatg ttttctttcc ccttcttttc tatggttaag      360

ttcatgtcat aggaagggga gaagtaacag ggtacacata ttgaccaaat cagggtaatt      420

ttgcatttgt aattttaaaa aatgctttct tcttttaata tacttttttg tttatcttat      480

ttctaatact ttccctaatc tctttctttc agggcaataa tgatacaatg tatcatgcct      540

ctttgcacca ttctaaagaa taacagtgat aatttctggg ttaaggcaat agcaatattt      600

ctgcatataa atatttctgc atataaattg taactgatgt aagaggtttc atattgctaa      660

tagcagctac aatccagcta ccattctgct tttattttat ggttgggata aggctggatt      720

attctgagtc caagctaggc ccttttgcta atcatgttca tacctcttat cttcctccca      780

cagcccaggc cctgctagcc aattcctccc agccaccaga gacccttcag cttcatatag      840

acaaagccat cagtggtcta cgtagcctca cttcactgct tcgggtactg ggagctcaga      900

aggaattgat gtcgcctcca gataccaccc cacctgctcc actccgaaca ctcacagtgg      960

atactttctg caagctcttc cgggtctacg ccaacttcct ccgggggaaa ctgaagctgt     1020

acacgggaga ggtctgcagg agaggggaca ggtga                                1055


<210>  90
<211>  2129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  luci-Con1

<400>  90
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gcctctttgc accattctaa     1260

agaataacag tgataatttc tgggttaagg caatagcaat atttctgcat ataaatattt     1320

ctgcatataa attgtaactg atgtaagagg tttcatattg ctaatagcag ctacaatcca     1380

gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg agtccaagct     1440

aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacagcaa ggatatgggc     1500

tcactgagac tacatcagct attctgatta cacccgaggg ggatgataaa ccgggcgcgg     1560

tcggtaaagt tgttccattt tttgaagcga aggttgtgga tctggatacc gggaaaacgc     1620

tgggcgttaa tcaaagaggc gaactgtgtg tgagaggtcc tatgattatg tccggttatg     1680

taaacaatcc ggaagcgacc aacgccttga ttgacaagga tggatggcta cattctggag     1740

acatagctta ctgggacgaa gacgaacact tcttcatcgt tgaccgcctg aagtctctga     1800

ttaagtacaa aggctatcag gtggctcccg ctgaattgga atccatcttg ctccaacacc     1860

ccaacatctt cgacgcaggt gtcgcaggtc ttcccgacga tgacgccggt gaacttcccg     1920

ccgccgttgt tgttttggag cacggaaaga cgatgacgga aaaagagatc gtggattacg     1980

tcgccagtca agtaacaacc gcgaaaaagt tgcgcggagg agttgtgttt gtggacgaag     2040

taccgaaagg tcttaccgga aaactcgacg caagaaaaat cagagagatc ctcataaagg     2100

ccaagaaggg cggaaagatc gccgtgtaa                                       2129


<210>  91
<211>  2295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  luci-3H4

<400>  91
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gccgagtaac gctgtttctc     1260

taacttgtag gaatgaattc agatatttcc agagaatgaa aaaaaatctt cagtagaagg     1320

taatgtacag gggtccggcc ttttcatttg gcgccggtga gagcacaccc tttgaacctg     1380

ttcacggata atgccgctgc agggagtaca ttacgcacca ttctaaagaa taacagtgat     1440

aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg     1500

taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct     1560

tttattttat ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta     1620

atcatgttca tacctcttat cttcctccca cagcaaggat atgggctcac tgagactaca     1680

tcagctattc tgattacacc cgagggggat gataaaccgg gcgcggtcgg taaagttgtt     1740

ccattttttg aagcgaaggt tgtggatctg gataccggga aaacgctggg cgttaatcaa     1800

agaggcgaac tgtgtgtgag aggtcctatg attatgtccg gttatgtaaa caatccggaa     1860

gcgaccaacg ccttgattga caaggatgga tggctacatt ctggagacat agcttactgg     1920

gacgaagacg aacacttctt catcgttgac cgcctgaagt ctctgattaa gtacaaaggc     1980

tatcaggtgg ctcccgctga attggaatcc atcttgctcc aacaccccaa catcttcgac     2040

gcaggtgtcg caggtcttcc cgacgatgac gccggtgaac ttcccgccgc cgttgttgtt     2100

ttggagcacg gaaagacgat gacggaaaaa gagatcgtgg attacgtcgc cagtcaagta     2160

acaaccgcga aaaagttgcg cggaggagtt gtgtttgtgg acgaagtacc gaaaggtctt     2220

accggaaaac tcgacgcaag aaaaatcaga gagatcctca taaaggccaa gaagggcgga     2280

aagatcgccg tgtaa                                                      2295


<210>  92
<211>  2295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  luci-6B4

<400>  92
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gccgagtaac gctgtttctc     1260

taacttgtag gaatgaattc agatatttcc agagaatgaa aaaaaatctt cagtagaagg     1320

taatgtacag gggtccggcc ttttcatttg gcgccggtga gagcacaccc ttgtgacctg     1380

tttacggata atgccgccgc agggagtaca ttacgcacca ttctaaagaa taacagtgat     1440

aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg     1500

taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct     1560

tttattttat ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta     1620

atcatgttca tacctcttat cttcctccca cagcaaggat atgggctcac tgagactaca     1680

tcagctattc tgattacacc cgagggggat gataaaccgg gcgcggtcgg taaagttgtt     1740

ccattttttg aagcgaaggt tgtggatctg gataccggga aaacgctggg cgttaatcaa     1800

agaggcgaac tgtgtgtgag aggtcctatg attatgtccg gttatgtaaa caatccggaa     1860

gcgaccaacg ccttgattga caaggatgga tggctacatt ctggagacat agcttactgg     1920

gacgaagacg aacacttctt catcgttgac cgcctgaagt ctctgattaa gtacaaaggc     1980

tatcaggtgg ctcccgctga attggaatcc atcttgctcc aacaccccaa catcttcgac     2040

gcaggtgtcg caggtcttcc cgacgatgac gccggtgaac ttcccgccgc cgttgttgtt     2100

ttggagcacg gaaagacgat gacggaaaaa gagatcgtgg attacgtcgc cagtcaagta     2160

acaaccgcga aaaagttgcg cggaggagtt gtgtttgtgg acgaagtacc gaaaggtctt     2220

accggaaaac tcgacgcaag aaaaatcaga gagatcctca taaaggccaa gaagggcgga     2280

aagatcgccg tgtaa                                                      2295


<210>  93
<211>  2295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Luci-15D10

<400>  93
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag ggtgagtcta     1020

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     1080

gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt     1140

aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct     1200

aatctctttc tttcagggca ataatgatac aatgtatcat gccgagtaac gctgtttctc     1260

taacttgtag gaatgaattc agatatttcc agagaatgaa aaaaaatctt cagtagaagg     1320

taatgtacag gggtccggcc ttttcatttg gcaccggtga gaacataccc ttcggacctg     1380

ttcacggata atgccgctgc agggagtaca ttacgcacca ttctaaagaa taacagtgat     1440

aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg     1500

taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct     1560

tttattttat ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta     1620

atcatgttca tacctcttat cttcctccca cagcaaggat atgggctcac tgagactaca     1680

tcagctattc tgattacacc cgagggggat gataaaccgg gcgcggtcgg taaagttgtt     1740

ccattttttg aagcgaaggt tgtggatctg gataccggga aaacgctggg cgttaatcaa     1800

agaggcgaac tgtgtgtgag aggtcctatg attatgtccg gttatgtaaa caatccggaa     1860

gcgaccaacg ccttgattga caaggatgga tggctacatt ctggagacat agcttactgg     1920

gacgaagacg aacacttctt catcgttgac cgcctgaagt ctctgattaa gtacaaaggc     1980

tatcaggtgg ctcccgctga attggaatcc atcttgctcc aacaccccaa catcttcgac     2040

gcaggtgtcg caggtcttcc cgacgatgac gccggtgaac ttcccgccgc cgttgttgtt     2100

ttggagcacg gaaagacgat gacggaaaaa gagatcgtgg attacgtcgc cagtcaagta     2160

acaaccgcga aaaagttgcg cggaggagtt gtgtttgtgg acgaagtacc gaaaggtctt     2220

accggaaaac tcgacgcaag aaaaatcaga gagatcctca taaaggccaa gaagggcgga     2280

aagatcgccg tgtaa                                                      2295


<210>  94
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  thiC aptamer with stem

<400>  94
guaauguguc ggagugccuu agggauuauu ccccuaaagc ugagaccgca uugcgggauc       60

cguugaaccu gaucaggcua auaccugcga agggaacaca uuac                       104


<210>  95
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  thiM aptamer with stem

<400>  95
guaaugucuc ggggugcccu ucugcgugaa ggcugagaaa uacccguauc accugaucug       60

gauaaugcca gcguagggaa gacauuac                                          88


<210>  96
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  thiC aptamer encoding sequence

<400>  96
gtcggagtgc cttagggatt attcccctaa agctgagacc gcattgcggg atccgttgaa       60

cctgatcagg ctaatacctg cgaagggaac                                        90


<210>  97
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  thiM aptamer encoding sequence

<400>  97
ctcggggtgc ccttctgcgt gaaggctgag aaatacccgt atcacctgat ctggataatg       60

ccagcgtagg gaag                                                         74


<210>  98
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified DHFR exon 2

<400>  98
gaatgaattc agatatttcc agagaatgaa aaaaaatctt cagtagaag                   49


