                         SEQUENCE LISTING

<110>  Genentech, Inc.
 
<120>  TIE2-BINDING AGENTS AND METHODS OF USE

<130>  P35891-WO

<150>  62/993930
<151>  2020-03-24

<150>  63/046318
<151>  2020-06-30

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  1
Met Phe Thr Met Thr Arg Ala Met Glu Glu Ala Leu Phe Gln His Phe 
1               5                   10                  15      

Met His Gln Lys Leu Gly Ile Ala Tyr Ala Ile His Lys Pro Phe Pro 
            20                  25                  30          

Phe Phe Glu Gly Leu Leu Asp Asn Ser Ile Ile Thr Lys Arg Met Tyr 
        35                  40                  45              

Met Glu Ser Leu Glu Ala Cys Arg Asn Leu Ile Pro Val Ser Arg Val 
    50                  55                  60                  

Val His Asn Ile Leu Thr Gln Leu Glu Arg Thr Phe Asn Leu Ser Leu 
65                  70                  75                  80  

Leu Val Thr Leu Phe Ser Gln Ile Asn Leu Arg Glu Tyr Pro Asn Leu 
                85                  90                  95      

Val Thr Ile Tyr Arg Ser Phe Lys Arg Val Gly Ala Ser Tyr Glu Trp 
            100                 105                 110         

Gln Ser Arg Asp Thr Pro Ile Leu Leu Glu Ala Pro Thr Gly Leu Ala 
        115                 120                 125             

Glu Gly Ser Ser Leu His Thr Pro Leu Ala Leu Pro Pro Pro Gln Pro 
    130                 135                 140                 

Pro Gln Pro Ser Cys Ser Pro Cys Ala Pro Arg Val Ser Glu Pro Gly 
145                 150                 155                 160 

Thr Ser Ser Gln Gln Ser Asp Glu Ile Leu Ser Glu Ser Pro Ser Pro 
                165                 170                 175     

Ser Asp Pro Val Leu Pro Leu Pro Ala Leu Ile Gln Glu Gly Arg Ser 
            180                 185                 190         

Thr Ser Val Thr Asn Asp Lys Leu Thr Ser Lys Met Asn Ala Glu Glu 
        195                 200                 205             

Asp Ser Glu Glu Met Pro Ser Leu Leu Thr Ser Thr Val Gln Val Ala 
    210                 215                 220                 

Ser Asp Asn Leu Ile Pro Gln Ile Arg Asp Lys Glu Asp Pro Gln Glu 
225                 230                 235                 240 

Met Pro His Ser Pro Leu Gly Ser Met Pro Glu Ile Arg Asp Asn Ser 
                245                 250                 255     

Pro Glu Pro Asn Asp Pro Glu Glu Pro Gln Glu Val Ser Ser Thr Pro 
            260                 265                 270         

Ser Asp Lys Lys Gly Lys Lys Arg Lys Arg Cys Ile Trp Ser Thr Pro 
        275                 280                 285             

Lys Arg Arg His Lys Lys Lys Ser Leu Pro Gly Gly Thr Ala Ser Ser 
    290                 295                 300                 

Arg His Gly Ile Gln Lys Lys Leu Lys Arg Val Asp Gln Val Pro Gln 
305                 310                 315                 320 

Lys Lys Asp Asp Ser Thr Cys Asn Ser Thr Val Glu Thr Arg Ala Gln 
                325                 330                 335     

Lys Ala Arg Thr Glu Cys Ala Arg Lys Ser Arg Ser Glu Glu Ile Ile 
            340                 345                 350         

Asp Gly Thr Ser Glu Met Asn Glu Gly Lys Arg Ser Gln Lys Thr Pro 
        355                 360                 365             

Ser Thr Pro Arg Arg Val Thr Gln Gly Ala Ala Ser Pro Gly His Gly 
    370                 375                 380                 

Ile Gln Glu Lys Leu Gln Val Val Asp Lys Val Thr Gln Arg Lys Asp 
385                 390                 395                 400 

Asp Ser Thr Trp Asn Ser Glu Val Met Met Arg Val Gln Lys Ala Arg 
                405                 410                 415     

Thr Lys Cys Ala Arg Lys Ser Arg Leu Lys Glu Lys Lys Lys Glu Lys 
            420                 425                 430         

Asp Ile Cys Ser Ser Ser Lys Arg Arg Phe Gln Lys Asn Ile His Arg 
        435                 440                 445             

Arg Gly Lys Pro Lys Ser Asp Thr Val Asp Phe His Cys Ser Lys Leu 
    450                 455                 460                 

Pro Val Thr Cys Gly Glu Ala Lys Gly Ile Leu Tyr Lys Lys Lys Met 
465                 470                 475                 480 

Lys His Gly Ser Ser Val Lys Cys Ile Arg Asn Glu Asp Gly Thr Trp 
                485                 490                 495     

Leu Thr Pro Asn Glu Phe Glu Val Glu Gly Lys Gly Arg Asn Ala Lys 
            500                 505                 510         

Asn Trp Lys Arg Asn Ile Arg Cys Glu Gly Met Thr Leu Gly Glu Leu 
        515                 520                 525             

Leu Lys Arg Lys Asn Ser Asp Glu Cys Glu Val Cys Cys Gln Gly Gly 
    530                 535                 540                 

Gln Leu Leu Cys Cys Gly Thr Cys Pro Arg Val Phe His Glu Asp Cys 
545                 550                 555                 560 

His Ile Pro Pro Val Glu Ala Lys Arg Met Leu Trp Ser Cys Thr Phe 
                565                 570                 575     

Cys Arg Met Lys Arg Ser Ser Gly Ser Gln Gln Cys His His Val Ser 
            580                 585                 590         

Lys Thr Leu Glu Arg Gln Met Gln Pro Gln Asp Gln Leu Ile Arg Asp 
        595                 600                 605             

Tyr Gly Glu Pro Phe Gln Glu Ala Met Trp Leu Asp Leu Val Lys Glu 
    610                 615                 620                 

Arg Leu Ile Thr Glu Met Tyr Thr Val Ala Trp Phe Val Arg Asp Met 
625                 630                 635                 640 

Arg Leu Met Phe Arg Asn His Lys Thr Phe Tyr Lys Ala Ser Asp Phe 
                645                 650                 655     

Gly Gln Val Gly Leu Asp Leu Glu Ala Glu Phe Glu Lys Asp Leu Lys 
            660                 665                 670         

Asp Val Leu Gly Phe His Glu Ala Asn Asp Gly Gly Phe Trp Thr Leu 
        675                 680                 685             

Pro 
    
<210>  2
<211>  1124
<212>  PRT
<213>  Macaca fascicularis

<400>  2
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      

Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          

Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              

Trp His Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  

Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  

Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      

Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         

Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             

Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 

Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 

Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     

His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         

Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             

Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn Arg Leu Cys 
    210                 215                 220                 

Thr Val Cys Val Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 

Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     

Arg His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Asp 
            260                 265                 270         

Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             

Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His His 
    290                 295                 300                 

Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Ser Asn Gly 
305                 310                 315                 320 

Glu Thr Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Arg Gln 
                325                 330                 335     

Gly Leu Gln Cys Glu Arg Glu Gly Ile Pro Arg Met Thr Pro Lys Ile 
            340                 345                 350         

Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro 
        355                 360                 365             

Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr 
    370                 375                 380                 

Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His 
385                 390                 395                 400 

Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro 
                405                 410                 415     

Pro Asp Ser Gly Val Trp Val Cys Ser Ala Asn Thr Val Ala Gly Met 
            420                 425                 430         

Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu 
        435                 440                 445             

Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn 
    450                 455                 460                 

Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys 
465                 470                 475                 480 

Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Arg His Ile Gln 
                485                 490                 495     

Val Thr Asn Glu Ile Val Thr Leu Asn His Leu Glu Pro Arg Thr Glu 
            500                 505                 510         

Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly 
        515                 520                 525             

His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro 
    530                 535                 540                 

Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn 
545                 550                 555                 560 

Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val 
                565                 570                 575     

Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys 
            580                 585                 590         

Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg 
        595                 600                 605             

Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu 
    610                 615                 620                 

Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro 
625                 630                 635                 640 

Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val 
                645                 650                 655     

Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile 
            660                 665                 670         

Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Ile Asp Val Lys 
        675                 680                 685             

Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro 
    690                 695                 700                 

Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser 
705                 710                 715                 720 

Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Glu 
                725                 730                 735     

Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
            740                 745                 750         

Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile 
        755                 760                 765             

Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala 
    770                 775                 780                 

Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr 
785                 790                 795                 800 

Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr 
                805                 810                 815     

Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
            820                 825                 830         

Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
        835                 840                 845             

Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
    850                 855                 860                 

Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
865                 870                 875                 880 

His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
                885                 890                 895     

Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
            900                 905                 910         

Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
        915                 920                 925             

Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
    930                 935                 940                 

Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
945                 950                 955                 960 

Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
                965                 970                 975     

Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
            980                 985                 990         

Val Lys Lys Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
        995                 1000                 1005             

Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Asn Ser Asp  Val Trp Ser 
    1010                 1015                 1020             

Tyr Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1025                 1030                 1035             

Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1040                 1045                 1050             

Gly Tyr  Arg Leu Glu Lys Pro  Leu Asn Cys Asp Asp  Glu Val Phe 
    1055                 1060                 1065             

Asp Leu  Met Arg Gln Cys Trp  Arg Glu Lys Pro Tyr  Glu Arg Pro 
    1070                 1075                 1080             

Ser Phe  Ala Gln Ile Leu Val  Ser Leu Asn Arg Met  Leu Glu Glu 
    1085                 1090                 1095             

Arg Lys  Thr Tyr Val Asn Thr  Thr Leu Tyr Glu Lys  Phe Thr Tyr 
    1100                 1105                 1110             

Ala Gly  Ile Asp Cys Ser Ala  Glu Glu Ala Ala 
    1115                 1120                 


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
Asn Thr Asp Ile Ser 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Met, Leu, Lys, Phe, Tyr, Arg, Asn, Gln, His, of Trp

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Phe, Tyr, Leu, Gln, Ile, Lys, or His

<400>  5

Arg Thr Arg Trp Ala Ser Xaa Ala Xaa Asp Tyr 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Arg Thr Arg Trp Ala Ser Trp Ala Met Asp Tyr 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
Gln Gln Ser Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
Phe Gly Gln Gly Thr Lys Val Glu Ile 
1               5                   


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<400>  19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Xaa Ala Xaa Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  24
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Cys Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  25
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Cys Lys Val Asp Lys 
                85                  90                  95      

Lys Val Glu Pro Lys Ser Cys Asp 
            100                 


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
Ser Tyr Trp Ile His 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
Ala Ile Ser Pro Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
Ser Arg Tyr Tyr Gly Gln Arg Leu Val Tyr Tyr Val Met Asp Tyr 
1               5                   10                  15  


<210>  31
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Ala Ile Ser Pro Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ser Arg Tyr Tyr Gly Gln Arg Leu Val Tyr Tyr Val Met Asp 
            100                 105                 110         

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  32
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Ala Ile Ser Pro Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ser Arg Tyr Tyr Gly Gln Arg Leu Val Tyr Tyr Val Met Asp 
            100                 105                 110         

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             

Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 

Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 

Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     

Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         

Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             

Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 

Lys Ser Cys Asp 
225             


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
Ser Ser Gly Ile Ser 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
Thr Ile Asn Pro Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
Phe Tyr Arg Phe Leu Ser Ser Gly Met Asp Tyr 
1               5                   10      


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Asn Pro Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Phe Tyr Arg Phe Leu Ser Ser Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Asn Pro Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Phe Tyr Arg Phe Leu Ser Ser Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
Gly Ser Trp Ile Ser 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
Arg Ile Asn Pro Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
Asn Asn Arg Phe Pro Thr Trp Phe Asp Tyr 
1               5                   10  


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          

Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Arg Ile Asn Pro Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asn Asn Arg Phe Pro Thr Trp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  42
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          

Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Arg Ile Asn Pro Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asn Asn Arg Phe Pro Thr Trp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220             


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
Asp Thr Tyr Ile His 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
Val Ile Tyr Pro Asp Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
Glu Phe Ala Cys Ala Arg Cys Val Tyr Gly 
1               5                   10  


<210>  46
<211>  235
<212>  PRT
<213>  Artificial Sequence

<400>  46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Thr 
            20                  25                  30          

Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Tyr Pro Asp Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
65                  70                  75                  80  

Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
                85                  90                  95      

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Phe Ala Cys Ala 
            100                 105                 110         

Arg Cys Val Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             

Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 

Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 

Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     

Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         

Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             

Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 

Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235 


<210>  47
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Thr 
            20                  25                  30          

Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Tyr Pro Asp Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
65                  70                  75                  80  

Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
                85                  90                  95      

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Phe Ala Cys Ala 
            100                 105                 110         

Arg Cys Val Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             

Val Ser Ser 
    130     


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
Asn Ser Ala Ile His 
1               5   


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
Ser Ile Thr Pro Tyr Asn Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
Arg Gln Ser Tyr Ser Tyr Val Met Asp Tyr 
1               5                   10  


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          

Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Ser Ile Thr Pro Tyr Asn Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Gln Ser Tyr Ser Tyr Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          

Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Ser Ile Thr Pro Tyr Asn Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Gln Ser Tyr Ser Tyr Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220             


<210>  53
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  54
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu Val 
225                 230                 235                 240 

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     

Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser Ala Ile His Trp Val 
            260                 265                 270         

Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Thr Pro 
        275                 280                 285             

Tyr Asn Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    290                 295                 300                 

Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 

Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gln Ser 
                325                 330                 335     

Tyr Ser Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            340                 345                 350         

Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        355                 360                 365             

Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    370                 375                 380                 

Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
385                 390                 395                 400 

Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                405                 410                 415     

Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            420                 425                 430         

Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        435                 440                 445             

Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    450                 455                 460                 

Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
465                 470                 475                 480 

Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg Thr Pro Glu Val 
                485                 490                 495     

Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            500                 505                 510         

Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        515                 520                 525             

Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    530                 535                 540                 

Val Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
545                 550                 555                 560 

Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                565                 570                 575     

Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            580                 585                 590         

Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        595                 600                 605             

Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    610                 615                 620                 

Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
625                 630                 635                 640 

Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                645                 650                 655     

Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala 
            660                 665                 670         

Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 


<210>  55
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Cys Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Cys Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  57
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Ser Pro Pro Cys 
225                 230         


<210>  58
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  59
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Cys Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  60
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Cys Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  61
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Cys Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  62
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Cys Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  63
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Cys Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  64
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Cys Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  65
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Cys Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  66
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Cys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  67
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Cys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  68
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Cys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  69
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69
Glu Arg Thr Phe Val Met Ile Lys Pro Asp Gly Val Gln Arg Gly Leu 
1               5                   10                  15      

Ile Gly Glu Ile Ile Ser Arg Phe Glu Arg Lys Gly Leu Lys Ile Val 
            20                  25                  30          

Ala Met Lys Met Met Arg Ile Ser Arg Glu Met Ala Glu Lys His Tyr 
        35                  40                  45              

Ala Glu His Arg Glu Lys Pro Phe Phe Ser Ala Leu Val Asp Tyr Ile 
    50                  55                  60                  

Thr Ser Gly Pro Val Val Ala Met Val Leu Glu Gly Lys Asn Ala Val 
65                  70                  75                  80  

Glu Val Val Arg Lys Met Val Gly Ala Thr Asn Pro Lys Glu Ala Ala 
                85                  90                  95      

Pro Gly Thr Ile Arg Gly Asp Phe Gly Leu Asp Val Gly Lys Asn Val 
            100                 105                 110         

Ile Phe Ala Ser Asp Ser Pro Glu Ser Ala Glu Arg Glu Ile Ser Leu 
        115                 120                 125             

Phe Phe Lys Asp Glu Glu Leu Val Glu Trp 
    130                 135             


<210>  70
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70
Glu Arg Thr Phe Val Met Ile Lys Pro Asp Gly Val Gln Arg Gly Leu 
1               5                   10                  15      

Ile Gly Glu Ile Ile Ser Arg Phe Glu Arg Lys Gly Phe Lys Ile Val 
            20                  25                  30          

Ala Met Lys Leu Met Arg Ile Ser Gln Glu Leu Ala Glu Lys His Tyr 
        35                  40                  45              

Ala Glu His Arg Glu Lys Pro Phe Phe Ser Gly Leu Val Asp Phe Ile 
    50                  55                  60                  

Thr Ser Gly Pro Val Val Ala Met Val Leu Glu Gly Lys Asn Val Val 
65                  70                  75                  80  

Glu Val Val Arg Lys Met Ile Gly Ala Thr Asn Pro Lys Glu Ala Ala 
                85                  90                  95      

Pro Gly Thr Ile Arg Gly Asp Phe Gly Met Ser Val Gly Lys Asn Val 
            100                 105                 110         

Ile Phe Gly Ser Asp Ser Leu Glu Ser Ala Glu Arg Glu Ile Ser Leu 
        115                 120                 125             

Phe Phe Lys Asp Glu Glu Leu Val Glu Trp 
    130                 135             


<210>  71
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71
Ser Thr Asn Lys Val Asn Lys Glu Arg Thr Phe Leu Ala Val Lys Pro 
1               5                   10                  15      

Asp Gly Val Ala Arg Gly Leu Val Gly Glu Ile Ile Ala Arg Tyr Glu 
            20                  25                  30          

Lys Lys Gly Phe Val Leu Val Gly Leu Lys Gln Leu Val Pro Thr Lys 
        35                  40                  45              

Asp Leu Ala Glu Ser His Tyr Ala Glu His Lys Glu Arg Pro Phe Phe 
    50                  55                  60                  

Gly Gly Leu Val Ser Phe Ile Thr Ser Gly Pro Val Val Ala Met Val 
65                  70                  75                  80  

Phe Glu Gly Lys Gly Val Val Ala Ser Ala Arg Leu Met Ile Gly Val 
                85                  90                  95      

Thr Asn Pro Leu Ala Ser Ala Pro Gly Ser Ile Arg Gly Asp Phe Gly 
            100                 105                 110         

Val Asp Val Gly Arg Asn Ile Ile Phe Gly Ser Asp Ser Val Glu Ser 
        115                 120                 125             

Ala Asn Arg Glu Ile Ala Leu Trp Phe Lys Pro Glu Glu Leu Leu Thr 
    130                 135                 140                 

Glu Val Lys Pro Asn Pro Asn Leu Tyr Glu 
145                 150                 


<210>  72
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72
Ala Asn Ser Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln 
1               5                   10                  15      

Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe 
            20                  25                  30          

Arg Leu Val Gly Leu Lys Phe Leu Gln Ala Ser Glu Asp Leu Leu Lys 
        35                  40                  45              

Glu His Tyr Thr Asp Leu Lys Asp Arg Pro Phe Phe Thr Gly Leu Val 
    50                  55                  60                  

Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Leu 
65                  70                  75                  80  

Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro Ala 
                85                  90                  95      

Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val Gly 
            100                 105                 110         

Arg Asn Ile Ile Phe Gly Ser Asp Ser Val Lys Ser Ala Glu Lys Glu 
        115                 120                 125             

Ile Ser Leu Trp Phe Gln Pro Glu Glu Leu Val Glu Tyr Lys Ser Cys 
    130                 135                 140                 

Ala Gln Asn Trp Ile Tyr Glu 
145                 150     


<210>  73
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73
Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln 
1               5                   10                  15      

Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe 
            20                  25                  30          

Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu Lys 
        35                  40                  45              

Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu Val 
    50                  55                  60                  

Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Leu 
65                  70                  75                  80  

Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro Ala 
                85                  90                  95      

Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val Gly 
            100                 105                 110         

Arg Asn Ile Ile Phe Gly Ser Asp Ser Val Glu Ser Ala Glu Lys Glu 
        115                 120                 125             

Ile His Leu Trp Phe Lys Pro Glu Glu Leu Ile Asp Tyr Lys Ser Cys 
    130                 135                 140                 

Ala His Asp Trp Val Tyr Glu 
145                 150     


<210>  74
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Gly Gly Gly Gly Ser Thr Asn Lys Val Asn Lys Glu 
225                 230                 235                 240 

Arg Thr Phe Leu Ala Val Lys Pro Asp Gly Val Ala Arg Gly Leu Val 
                245                 250                 255     

Gly Glu Ile Ile Ala Arg Tyr Glu Lys Lys Gly Phe Val Leu Val Gly 
            260                 265                 270         

Leu Lys Gln Leu Val Pro Thr Lys Asp Leu Ala Glu Ser His Tyr Ala 
        275                 280                 285             

Glu His Lys Glu Arg Pro Phe Phe Gly Gly Leu Val Ser Phe Ile Thr 
    290                 295                 300                 

Ser Gly Pro Val Val Ala Met Val Phe Glu Gly Lys Gly Val Val Ala 
305                 310                 315                 320 

Ser Ala Arg Leu Met Ile Gly Val Thr Asn Pro Leu Ala Ser Ala Pro 
                325                 330                 335     

Gly Ser Ile Arg Gly Asp Phe Gly Val Asp Val Gly Arg Asn Ile Ile 
            340                 345                 350         

Phe Gly Ser Asp Ser Val Glu Ser Ala Asn Arg Glu Ile Ala Leu Trp 
        355                 360                 365             

Phe Lys Pro Glu Glu Leu Leu Thr Glu Val Lys Pro Asn Pro Asn Leu 
    370                 375                 380                 

Tyr Glu 
385     


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75
Cys Asp Lys Thr His Thr 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76
Cys Asp Lys Thr His Leu 
1               5       


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77
Cys Asp Lys Thr His 
1               5   


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78
Cys Asp Lys Thr 
1               


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any amino acid other than Thr

<400>  79
Cys Asp Lys Thr His Xaa 
1               5       


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80
Cys Asp Lys Thr His Thr Cys 
1               5           


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81
Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82
Cys Asp Lys Thr His Thr Cys Pro Pro Ser 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83
Cys Asp Lys Thr His Thr Ser Pro Pro Cys 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84
Cys Asp Lys Thr His Thr Ala Pro Pro Cys 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85
Cys Asp Lys Thr His Thr Ser Gly Gly Cys 
1               5                   10  


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86
Cys Tyr Gly Pro Pro Cys 
1               5       

<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87
Cys Pro Pro Cys 
1                     

<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88
Ser Pro Pro Ser
1                     


<210>  89
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Ser Pro Pro Cys 
225                 230         


<210>  90
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Trp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  91
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is Met, Leu, Lys, Phe, Tyr, Arg, Asn, Gln, His, of Trp

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Phe, Tyr, Leu, Gln, Ile, Lys, or His

<400>  91
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Xaa Ala Xaa Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


<210>  92
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is Met, Leu, Lys, Phe, Tyr, Arg, Asn, Gln, His, of Trp

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Phe, Tyr, Leu, Gln, Ile, Lys, or His

<400>  92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 
            20                  25                  30          

Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Arg Ile Ser Pro Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Thr Arg Trp Ala Ser Xaa Ala Xaa Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Cys Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


