                               SEQUENCE LISTING

<110> THE BROAD INSTITUTE, INC.
      THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> COMPOSITIONS AND METHODS FOR TREATING A NEURODEGENERATIVE OR 
      DEVELOPMENTAL DISORDER

<130> 167741.022901/PCT

<140> PCT/US2021/024082
<141> 2021-03-25

<150> 63/000,244
<151> 2020-03-26

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 770
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210> 2
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 2
agagcaagga cgcggcggat cccactcgca cagcagcgca ctcggtgccc cgcgcagggt       60

cgcagatgct gcccggtttg gcactgctcc tgctggccgc ctggacggct cgggcgctgg      120

aggtacccac tgatggtaat gctggcctgc tggctgaacc ccagattgcc atgttctgtg      180

gcagactgaa catgcacatg aatgtccaga atgggaagtg ggattcagat ccatcaggga      240

ccaaaacctg cattgatacc aaggaaggca tcctgcagta ttgccaagaa gtctaccctg      300

aactgcagat caccaatgtg gtagaagcca accaaccagt gaccatccag aactggtgca      360

agcggggccg caagcagtgc aagacccatc cccactttgt gattccctac cgctgcttag      420

ttggtgagtt tgtaagtgat gcccttctcg ttcctgacaa gtgcaaattc ttacaccagg      480

agaggatgga tgtttgcgaa actcatcttc actggcacac cgtcgccaaa gagacatgca      540

gtgagaagag taccaacttg catgactacg gcatgttgct gccctgcgga attgacaagt      600

tccgaggggt agagtttgtg tgttgcccac tggctgaaga aagtgacaat gtggattctg      660

ctgatgcgga ggaggatgac tcggatgtct ggtggggcgg agcagacaca gactatgcag      720

atgggagtga agacaaagta gtagaagtag cagaggagga agaagtggct gaggtggaag      780

aagaagaagc cgatgatgac gaggacgatg aggatggtga tgaggtagag gaagaggctg      840

aggaacccta cgaagaagcc acagagagaa ccaccagcat tgccaccacc accaccacca      900

ccacagagtc tgtggaagag gtggttcgag aggtgtgctc tgaacaagcc gagacggggc      960

cgtgccgagc aatgatctcc cgctggtact ttgatgtgac tgaagggaag tgtgccccat     1020

tcttttacgg cggatgtggc ggcaaccgga acaactttga cacagaagag tactgcatgg     1080

ccgtgtgtgg cagcgccatg tcccaaagtt tactcaagac tacccaggaa cctcttgccc     1140

gagatcctgt taaactccct acaacagcag ccagtacccc tgatgccgtt gacaagtatc     1200

tcgagacacc tggggatgag aatgaacatg cccatttcca gaaagccaaa gagaggcttg     1260

aggccaagca ccgagagaga atgtcccagg tcatgagaga atgggaagag gcagaacgtc     1320

aagcaaagaa cttgcctaaa gctgataaga aggcagttat ccagcatttc caggagaaag     1380

tggaatcttt ggaacaggaa gcagccaacg agagacagca gctggtggag acacacatgg     1440

ccagagtgga agccatgctc aatgaccgcc gccgcctggc cctggagaac tacatcaccg     1500

ctctgcaggc tgttcctcct cggcctcgtc acgtgttcaa tatgctaaag aagtatgtcc     1560

gcgcagaaca gaaggacaga cagcacaccc taaagcattt cgagcatgtg cgcatggtgg     1620

atcccaagaa agccgctcag atccggtccc aggttatgac acacctccgt gtgatttatg     1680

agcgcatgaa tcagtctctc tccctgctct acaacgtgcc tgcagtggcc gaggagattc     1740

aggatgaagt tgatgagctg cttcagaaag agcaaaacta ttcagatgac gtcttggcca     1800

acatgattag tgaaccaagg atcagttacg gaaacgatgc tctcatgcca tctttgaccg     1860

aaacgaaaac caccgtggag ctccttcccg tgaatggaga gttcagcctg gacgatctcc     1920

agccgtggca ttcttttggg gctgactctg tgccagccaa cacagaaaac gaagttgagc     1980

ctgttgatgc ccgccctgct gccgaccgag gactgaccac tcgaccaggt tctgggttga     2040

caaatatcaa gacggaggag atctctgaag tgaagatgga tgcagaattc cgacatgact     2100

caggatatga agttcatcat caaaaattgg tgttctttgc agaagatgtg ggttcaaaca     2160

aaggtgcaat cattggactc atggtgggcg gtgttgtcat agcgacagtg atcgtcatca     2220

ccttggtgat gctgaagaag aaacagtaca catccattca tcatggtgtg gtggaggttg     2280

acgccgctgt caccccagag gagcgccacc tgtccaagat gcagcagaac ggctacgaaa     2340

atccaaccta caagttcttt gagcagatgc agaactag                             2378


<210> 3
<211> 763
<212> PRT
<213> Homo sapiens

<400> 3
Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ser Ser Gly Thr Ser Asn Ser Gly Arg Ala Arg 
        515                 520                 525             


Ser Asp Pro Thr His Gln His Arg His Ser Gly Gly His Phe Thr Ala 
    530                 535                 540                 


Ala Val Gln Ala Met Asp Cys Glu Thr His Ser Pro Gln Val Arg Gln 
545                 550                 555                 560 


Gln Phe Pro Ala Pro Leu Gly Trp Ser Gly Thr Glu Ala Pro Thr Gln 
                565                 570                 575     


Val Thr Val Glu Thr His Pro Val Gln Glu Thr Thr Phe His Val Ala 
            580                 585                 590         


Pro Gln Gln Asn Ala Leu His His His His Gly Asn Ser Ser His His 
        595                 600                 605             


His His His His His His His His His His His Gly Gln Gln Ala Leu 
    610                 615                 620                 


Gly Asn Arg Thr Arg Pro Arg Val Tyr Asn Ser Pro Thr Asn Ser Ser 
625                 630                 635                 640 


Ser Thr Gln Asp Ser Met Glu Val Gly His Ser His His Ser Met Thr 
                645                 650                 655     


Ser Leu Ser Ser Ser Thr Thr Ser Ser Ser Thr Ser Ser Ser Ser Thr 
            660                 665                 670         


Gly Asn Gln Gly Asn Gln Ala Tyr Gln Asn Arg Pro Val Ala Ala Asn 
        675                 680                 685             


Thr Leu Asp Phe Gly Gln Asn Gly Ala Met Asp Val Asn Leu Thr Val 
    690                 695                 700                 


Tyr Ser Asn Pro Arg Gln Glu Thr Gly Ile Ala Gly His Pro Thr Tyr 
705                 710                 715                 720 


Gln Phe Ser Ala Asn Thr Gly Pro Ala His Tyr Met Thr Glu Gly His 
                725                 730                 735     


Leu Thr Met Arg Gln Gly Ala Asp Arg Glu Glu Ser Pro Met Thr Gly 
            740                 745                 750         


Val Cys Val Gln Gln Ser Pro Val Ala Ser Ser 
        755                 760             


<210> 4
<211> 2422
<212> DNA
<213> Homo sapiens

<400> 4
gttatagttt tgccgctgga ctcttccctc ccttccccca ccccatcagg atgatatgag       60

acttgaaaga agacgatgca tacaggagga gagacttcag catgcaaacc ttcatctgtt      120

cggcttgcac cgtcattttc attccatgct gctggccttc agatggctgg acagatgccc      180

cattcacatc agtacagtga ccgtcgccag ccaaacataa gtgaccaaca ggtttctgcc      240

ttatcatatt ctgaccagat tcagcaacct ctaactaacc aggtgatgcc tgatattgtc      300

atgttacaga ggcggatgcc ccaaaccttc cgtgacccag caactgctcc cctgagaaaa      360

ctttctgttg acttgatcaa aacatacaag catattaatg aggtttacta tgcaaaaaag      420

aagcgaagac accaacaggg ccagggagac gattctagtc ataagaagga acggaaggtt      480

tacaatgatg gttatgatga tgataactat gattatattg taaaaaacgg agaaaagtgg      540

atggatcgtt acgaaattga ctccttgata ggcaaaggtt cctttggaca ggttgtaaag      600

gcatatgatc gtgtggagca agaatgggtt gccattaaaa taataaagaa caagaaggct      660

tttctgaatc aagcacagat agaagtgcga cttcttgagc tcatgaacaa acatgacact      720

gaaatgaaat actacatagt gcatttgaaa cgccacttta tgtttcgaaa ccatctctgt      780

ttagtttttg aaatgctgtc ctacaacctc tatgacttgc tgagaaacac caatttccga      840

ggggtctctt tgaacctaac acgaaagttt gcgcaacaga tgtgcactgc actgcttttc      900

cttgcgactc cagaacttag tatcattcac tgtgatctaa aacctgaaaa tatccttctt      960

tgtaacccca aacgcagtgc aatcaagata gttgactttg gcagttcttg tcagttgggg     1020

cagaggatat accagtatat tcagagtcgc ttttatcggt ctccagaggt gctactggga     1080

atgccttatg accttgccat tgatatgtgg tccctcgggt gtattttggt tgaaatgcac     1140

actggagaac ctctgttcag tggtgccaat gaggtagatc agatgaataa aatagtggaa     1200

gttctgggta ttccacctgc tcatattctt gaccaagcac caaaagcaag aaagttcttt     1260

gagaagttgc cagatggcac ttggaactta aagaagacca aagatggaaa acgggagtac     1320

aaaccaccag gaacccgtaa acttcataac attcttggag tggaaacagg aggacctggt     1380

gggcgacgtg ctggggagtc aggtcatacg gtcgctgact acttgaagtt caaagacctc     1440

attttaagga tgcttgatta tgaccccaaa actcgaattc aaccttatta tgctctgcag     1500

cacagtttct tcaagaaaac agctgatgaa ggtacaaata caagtaatag tgtatctaca     1560

agccccgcca tggagcagtc tcagtcttcg ggcaccacct ccagtacatc gtcaagctca     1620

ggtggctcat cggggacaag caacagtggg agagcccggt cggatccgac gcaccagcat     1680

cggcacagtg gtgggcactt cacagctgcc gtgcaggcca tggactgcga gacacacagt     1740

ccccaggtgc gtcagcaatt tcctgctcct cttggttggt caggcactga agctcctaca     1800

caggtcactg ttgaaactca tcctgttcaa gaaacaacct ttcatgtagc ccctcaacag     1860

aatgcattgc atcatcacca tggtaacagt tcccatcatc accaccacca ccaccaccat     1920

caccaccacc atggacaaca agccttgggt aaccggacca ggccaagggt ctacaattct     1980

ccaacgaata gctcctctac ccaagattct atggaggttg gccacagtca ccactccatg     2040

acatccctgt cttcctcaac gacttcttcc tcgacatctt cctcctctac tggtaaccaa     2100

ggcaatcagg cctaccacaa tcgcccagtg gctgctaata ccttggactt tggacagaat     2160

ggagctatgg acgttaattt gaccgtctac tccaatcccc gccaagagac tggcatagct     2220

ggacatccaa cataccaatt ttctgctaat acaggtcctg cacattacat gactgaagga     2280

catctgacga tgaggcaagg ggctgataga gaagagtccc ccatgacagg agtttgtgtg     2340

caacagagtc ctgtagctag ctcgtgacta cattgaaact tgagtttgtt tcttgtgtgt     2400

ttttatagaa gtggtgtttt tt                                              2422


<210> 5
<211> 632
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Glu Leu Val Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Phe Val Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg 
        35                  40                  45              


Phe Pro Pro Pro Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Glu Lys Glu Pro Cys Cys Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Ile Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Ile Glu Arg Leu 
            100                 105                 110         


Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp Thr Phe His Lys 
        115                 120                 125             


Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met Cys Ala Lys Glu 
    130                 135                 140                 


Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Phe Ser Val Thr 
145                 150                 155                 160 


Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser Ile Asn Glu Val 
                165                 170                 175     


Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His Phe Arg Ser Leu 
            180                 185                 190         


Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu Ala Ser Lys Gln 
        195                 200                 205             


Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His Glu Gln Phe Ile 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ala Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp Gln Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp Val Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Leu Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Ala 
305                 310                 315                 320 


Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile Met Pro Pro Asn 
                325                 330                 335     


Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn Ala Pro Glu Glu 
            340                 345                 350         


Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His Phe Ser Gln Pro 
        355                 360                 365             


Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser Ser Val Val Ala 
    370                 375                 380                 


Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln Gly Met Val Pro 
385                 390                 395                 400 


Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu 
                405                 410                 415     


Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu 
            420                 425                 430         


Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser 
        435                 440                 445             


Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp 
    450                 455                 460                 


Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly 
465                 470                 475                 480 


His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala 
                485                 490                 495     


Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp 
            500                 505                 510         


Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg 
        515                 520                 525             


Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg 
    530                 535                 540                 


Gly Arg Gly Gly Gly Phe Lys Gly Asn Asp Asp His Ser Arg Thr Asp 
545                 550                 555                 560 


Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly 
                565                 570                 575     


Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr 
            580                 585                 590         


Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly 
        595                 600                 605             


Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln 
    610                 615                 620                 


Gln Pro Leu Val Asn Gly Val Pro 
625                 630         


<210> 6
<211> 4362
<212> DNA
<213> Homo sapiens

<400> 6
acggcgagcg cgggcggcgg cggtgacgga ggcgccgctg ccagggggcg tgcggcagcg       60

cggcggcggc ggcggcggcg gcggcggcgg aggcggcggc ggcggcggcg gcggcggcgg      120

aggcggcggc ggcggcggcg gcggcggcgg ctgggcctcg agcgcccgca gcccacctct      180

cgggggcggg ctcccggcgc tagcagggct gaagagaaga tggaggagct ggtggtggaa      240

gtgcggggct ccaatggcgc tttctacaag gcatttgtaa aggatgttca tgaagattca      300

ataacagttg catttgaaaa caactggcag cctgataggc agattccatt tcatgatgtc      360

agattcccac ctcctgtagg ttataataaa gatataaatg aaagtgatga agttgaggtg      420

tattccagag caaatgaaaa agagccttgc tgttggtggt tagctaaagt gaggatgata      480

aagggtgagt tttatgtgat agaatatgca gcatgtgatg caacttacaa tgaaattgtc      540

acaattgaac gtctaagatc tgttaatccc aacaaacctg ccacaaaaga tactttccat      600

aagatcaagc tggatgtgcc agaagactta cggcaaatgt gtgccaaaga ggcggcacat      660

aaggatttta aaaaggcagt tggtgccttt tctgtaactt atgatccaga aaattatcag      720

cttgtcattt tgtccatcaa tgaagtcacc tcaaagcgag cacatatgct gattgacatg      780

cactttcgga gtctgcgcac taagttgtct ctgataatga gaaatgaaga agctagtaag      840

cagctggaga gttcaaggca gcttgcctcg agatttcatg aacagtttat cgtaagagaa      900

gatctgatgg gtctagctat tggtactcat ggtgctaata ttcagcaagc tagaaaagta      960

cctggggtca ctgctattga tctagatgaa gatacctgca catttcatat ttatggagag     1020

gatcaggatg cagtgaaaaa agctagaagc tttctcgaat ttgctgaaga tgtaatacaa     1080

gttccaagga acttagtagg caaagtaata ggaaaaaatg gaaagctgat tcaggagatt     1140

gtggacaagt caggagttgt gagggtgagg attgaggctg aaaatgagaa aaatgttcca     1200

caagaagagg aaattatgcc accaaattcc cttccttcca ataattcaag ggttggacct     1260

aatgccccag aagaaaaaaa acatttagat ataaaggaaa acagcaccca tttttctcaa     1320

cctaacagta caaaagtcca gagggtgtta gtggcttcat cagttgtagc aggggaatcc     1380

cagaaacctg aactcaaggc ttggcagggt atggtaccat ttgtttttgt gggaacaaag     1440

gacagcatcg ctaatgccac tgttcttttg gattatcacc tgaactattt aaaggaagta     1500

gaccagttgc gtttggagag attacaaatt gatgagcagt tgcgacagat tggagctagt     1560

tctagaccac caccaaatcg tacagataag gaaaaaagct atgtgactga tgatggtcaa     1620

ggaatgggtc gaggtagtag accttacaga aatagggggc acggcagacg cggtcctgga     1680

tatacttcag gaactaattc tgaagcatca aatgcttctg aaacagaatc tgaccacaga     1740

gacgaactca gtgattggtc attagctcca acagaggaag agagggagag cttcctgcgc     1800

agaggagacg gacggcggcg tggaggggga ggaagaggac aaggaggaag aggacgtgga     1860

ggaggcttca aaggaaacga cgatcactcc cgaacagata atcgtccacg taatccaaga     1920

gaggctaaag gaagaacaac agatggatcc cttcagatca gagttgactg caataatgaa     1980

aggagtgtcc acactaaaac attacagaat acctccagtg aaggtagtcg gctgcgcacg     2040

ggtaaagatc gtaaccagaa gaaagagaag ccagacagcg tggatggtca gcaaccactc     2100

gtgaatggag taccctaaac tgcataattc tgaagttata tttcctatac catttccgta     2160

attcttattc catattagaa aactttgtta ggccaaagac aaatagtagg caagatggca     2220

cagggcatga aatgaacaca aattatgcta agaatttttt attttttggt attggccata     2280

agcaacaatt ttcagatttg cacaaaaaga taccttaaaa tttgaaacat tgcttttaaa     2340

actacttagc acttcagggc agattttagt tttattttct aaagtactga gcagtgatat     2400

tctttgttaa tttggaccat tttcctgcat tgggtgatca ttcaccagta cattctcagt     2460

ttttcttaat atatagcatt tatggtaatc atattagact tctgttttca atctcgtata     2520

gaagtcttca tgaaatgcta tgtcatttca tgtcctgtgt cagtttatgt tttggtccac     2580

ttttccagta ttttagtgga ccctgaaatg tgtgtgatgt gacatttgtc attttcatta     2640

gcaaaaaaag ttgtatgatc tgtgcctttt ttatatcttg gcaggtagga atattatatt     2700

tggatgcaga gttcagggaa gataagttgg aaacactaaa tgttaaagat gtagcaaacc     2760

ctgtcaaaca ttagtacttt atagaagaat gcatgctttc catatttttt tccttacata     2820

aacatcaggt taggcagtat aaagaatagg acttgttttt gtttttgttt tgttgcactg     2880

aagtttgata aatagtgtta ttgagagaga tgtgtaattt ttctgtatag acaggagaag     2940

aaagaactat cttcatctga gagaggctaa aatgttttca gctaggaaca aatcttcctg     3000

gtcgaaagtt agtaggatat gcctgctctt tggcctgatg accaatttta acttagagct     3060

ttttttttta attttgtctg ccccaagttt tgtgaaattt ttcatatttt aatttcaagc     3120

ttattttgga gagataggaa ggtcatttcc atgtatgcat aataatcctg caaagtacag     3180

gtactttgtc taagaaacat tggaagcagg ttaaatgttt tgtaaacttt gaaatatatg     3240

gtctaatgtt taagcagaat tggaaaagac taagatcggt taacaaataa caactttttt     3300

ttcttttttt cttttgtttt ttgaagtgtt ggggtttggt tttgtttttt gagtcttttt     3360

tttttaagtg aaatttattg aggaaaaata tgtgaaggac cttcactcta agatgttata     3420

tttttcttaa aaagtaactc ctagtagggg taccactgaa tctgtacaga gccgtaaaaa     3480

ctgaagttct gcctctgatg tattttgtga gtttgtttct ttgaattttc attttacagt     3540

tacttttcct tgcatacaaa caagcatata aaatggcaac aaactgcaca tgatttcaca     3600

aatattaaaa agtcttttaa aaagtattgc caaacattaa tgttgatttc tagttattta     3660

ttctgggaat gtatagtatt tgaaaacaga aattggtacc ttgcacacat catctgtaag     3720

ctgtttggtt ttaaaatact gtagataatt aaccaaggta gaatgacctt gtaatgtaac     3780

tgctcttggg caatattctc tgtacatatt agcgacaaca gattggattt tatgttgaca     3840

tttgtttggt tatagtgcaa tatattttgt atgcaagcag tttcaataaa gtttgatctt     3900

cctctgctaa attgatgttg atgcaatcct tacaaatgat tgcttttaaa attttaagct     3960

aggaaaagaa atctatagaa agtgttctgt tacaaaatgt aactgttacc attggaaatt     4020

tcacgtcata ggaagttagc ctttatctac ccaactttca agaaggttct ttaataaagc     4080

gaaaactcaa ccaaatggta cttttccaca gtgtaccatt aaaatatgca ctagtctctt     4140

tttacaaggc tgtattcagc aagggcctaa cttgcttaaa gtgtaattac taacttctaa     4200

aactgtactt tgattcacat gttttcaaat ggagttggag ttcattcata ttacaatatt     4260

tgtgtgctaa acgtgtatgt ttttcagttc aaagtcatga tgtttttaaa atcttattaa     4320

agtttcaaaa atctgaagat tgtttatcta gatgtaaatt tt                        4362


<210> 7
<211> 852
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210> 8
<211> 3085
<212> DNA
<213> Homo sapiens

<400> 8
ggcgcgtgcg tacgcgacgg cggttggcgg cgcgcgggca gcgtgaagcg aggcgaggca       60

aggcttttcg gacccacgga gcgacagagc gagcggcccc tacggccgtc ggcggcccgg      120

cggcccgaga tgttatctgg gaagaaggcg gcagccgcgg cggcggcggc tgcagcggca      180

gcaaccggga cggaggctgg ccctgggaca gcaggcggct ccgagaacgg gtctgaggtg      240

gccgcgcagc ccgcgggcct gtcgggccca gccgaggtcg ggccgggggc ggtgggggag      300

cgcacacccc gcaagaaaga gcctccgcgg gcctcgcccc ccgggggcct ggcggaaccg      360

ccggggtccg cagggcctca ggccggccct actgtcgtgc ctgggtctgc gacccccatg      420

gaaactggaa tagcagagac tccggagggg cgtcggacca gccggcgcaa gcgggcgaag      480

gtagagtaca gagagatgga tgaaagcttg gccaacctct cagaagatga gtattattca      540

gaagaagaga gaaatgccaa agcagagaag gaaaagaagc ttcccccacc accccctcaa      600

gccccacctg aggaagaaaa tgaaagtgag cctgaagaac catcggggca agcaggagga      660

cttcaagacg acagttctgg agggtatgga gacggccaag catcaggtgt ggagggcgca      720

gctttccaga gccgacttcc tcatgaccgg atgacttctc aagaagcagc ctgttttcca      780

gatattatca gtggaccaca acagacccag aaggtttttc ttttcattag aaaccgcaca      840

ctgcagttgt ggttggataa tccaaagatt cagctgacat ttgaggctac tctccaacaa      900

ttagaagcac cttataacag tgatactgtg cttgtccacc gagttcacag ttatttagag      960

cgtcatggtc ttatcaactt cggcatctat aagaggataa aacccctacc aactaaaaag     1020

acaggaaagg taattattat aggctctggg gtctcaggct tggcagcagc tcgacagtta     1080

caaagttttg gaatggatgt cacacttttg gaagccaggg atcgtgtggg tggacgagtt     1140

gccacatttc gcaaaggaaa ctatgtagct gatcttggag ccatggtggt aacaggtctt     1200

ggagggaatc ctatggctgt ggtcagcaaa caagtaaata tggaactggc caagatcaag     1260

caaaaatgcc cactttatga agccaacgga caagctgaca ctgtcaaggt tcctaaagag     1320

aaagatgaaa tggtagagca agagtttaac cggttgctag aagctacatc ttaccttagt     1380

catcaactag acttcaatgt cctcaataat aagcctgtgt cccttggcca ggcattggaa     1440

gttgtcattc agttacaaga gaagcatgtc aaagatgagc agattgaaca ttggaagaag     1500

atagtgaaaa ctcaggaaga attgaaagaa cttcttaata agatggtaaa tttgaaagag     1560

aaaattaaag aactccatca gcaatacaaa gaagcatctg aagtaaagcc acccagagat     1620

attactgccg agttcttagt gaaaagcaaa cacagggatc tgaccgccct atgcaaggaa     1680

tatgatgaat tagctgaaac acaaggaaag ctagaagaaa aacttcagga gttggaagcg     1740

aatcccccaa gtgatgtata tctctcatca agagacagac aaatacttga ttggcatttt     1800

gcaaatcttg aatttgctaa tgccacacct ctctcaactc tctcccttaa gcactgggat     1860

caggatgatg actttgagtt cactggcagc cacctgacag taaggaatgg ctactcgtgt     1920

gtgcctgtgg ctttagcaga aggcctagac attaaactga atacagcagt gcgacaggtt     1980

cgctacacgg cttcaggatg tgaagtgata gctgtgaata cccgctccac gagtcaaacc     2040

tttatttata aatgcgacgc agttctctgt acccttcccc tgggtgtgct gaagcagcag     2100

ccaccagccg ttcagtttgt gccacctctc cctgagtgga aaacatctgc agtccaaagg     2160

atgggatttg gcaaccttaa caaggtggtg ttgtgttttg atcgggtgtt ctgggatcca     2220

agtgtcaatt tgttcgggca tgttggcagt acgactgcca gcaggggtga gctcttcctc     2280

ttctggaacc tctataaagc tccaatactg ttggcactag tggcaggaga agctgctggt     2340

atcatggaaa acataagtga cgatgtgatt gttggccgat gcctggccat tctcaaaggg     2400

atttttggta gcagtgcagt acctcagccc aaagaaactg tggtgtctcg ttggcgtgct     2460

gatccctggg ctcggggctc ttattcctat gttgctgcag gatcatctgg aaatgactat     2520

gatttaatgg ctcagccaat cactcctggc ccctcgattc caggtgcccc acagccgatt     2580

ccacgactct tctttgcggg agaacatacg atccgtaact acccagccac agtgcatggt     2640

gctctgctga gtgggctgcg agaagcggga agaattgcag accagttttt gggggccatg     2700

tatacgctgc ctcgccaggc cacaccaggt gttcctgcac agcagtcccc aagcatgtga     2760

gacagatgca ttctaaggga agaggcccat gtgcctgttt ctgccatgta aggaaggctc     2820

ttctagcaat actagatccc actgagaaaa tccaccctgg catctgggct cctgatcagc     2880

tgatggagct cctgatttga caaaggagct tgcctccttt gaatgaccta gagcacaggg     2940

aggaacttgt ccattagttt ggaattgtgt tcttcgtaaa gactgaggca agcaagtgct     3000

gtgaaataac atcatcttag tcccttggtg tgtggggttt ttgttttttt tttatatttt     3060

gagaataaaa cttcatataa aattg                                           3085


<210> 9
<211> 3142
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
    50                  55                  60                  


Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val 
65                  70                  75                  80  


Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys 
                85                  90                  95      


Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala 
            100                 105                 110         


Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala 
        115                 120                 125             


Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg 
    130                 135                 140                 


Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp 
145                 150                 155                 160 


Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys 
                165                 170                 175     


Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu 
            180                 185                 190         


Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn 
        195                 200                 205             


Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val 
    210                 215                 220                 


Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly 
225                 230                 235                 240 


Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile 
                245                 250                 255     


Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly 
            260                 265                 270         


Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr 
        275                 280                 285             


Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp 
    290                 295                 300                 


Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr 
305                 310                 315                 320 


Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly 
                325                 330                 335     


Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu 
            340                 345                 350         


Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln 
        355                 360                 365             


Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe 
    370                 375                 380                 


Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly 
385                 390                 395                 400 


Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg 
                405                 410                 415     


Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser 
            420                 425                 430         


Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu 
        435                 440                 445             


Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser 
    450                 455                 460                 


Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala 
465                 470                 475                 480 


Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr 
                485                 490                 495     


Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu 
            500                 505                 510         


Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp 
        515                 520                 525             


Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro 
    530                 535                 540                 


Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp 
545                 550                 555                 560 


Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser 
                565                 570                 575     


Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly 
            580                 585                 590         


Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile 
        595                 600                 605             


Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu 
    610                 615                 620                 


Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser 
625                 630                 635                 640 


Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro 
                645                 650                 655     


Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln 
            660                 665                 670         


Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu 
        675                 680                 685             


Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp 
    690                 695                 700                 


Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly 
705                 710                 715                 720 


Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys 
                725                 730                 735     


Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp 
            740                 745                 750         


Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr 
        755                 760                 765             


Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg 
    770                 775                 780                 


Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn 
785                 790                 795                 800 


Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys 
                805                 810                 815     


Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn 
            820                 825                 830         


Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln 
        835                 840                 845             


Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val 
    850                 855                 860                 


Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val 
865                 870                 875                 880 


Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His 
                885                 890                 895     


Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val 
            900                 905                 910         


Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala 
        915                 920                 925             


Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln 
    930                 935                 940                 


Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val 
945                 950                 955                 960 


Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser 
                965                 970                 975     


Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser 
            980                 985                 990         


Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg Val  Ile Ala Ala 
        995                 1000                 1005             


Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg Ala  Leu Thr Phe 
    1010                 1015                 1020             


Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr Ala  Phe Pro Val 
    1025                 1030                 1035             


Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val Pro  Pro Leu Ser 
    1040                 1045                 1050             


Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val Gly  Met Ala Thr 
    1055                 1060                 1065             


Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe Pro  Leu Asp Leu 
    1070                 1075                 1080             


Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly Asn  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp Ala  Ser Glu Glu 
    1100                 1105                 1110             


Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu Val  Trp Pro Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu Gln  Leu Phe Ser 
    1130                 1135                 1140             


His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His Val  Leu Asp Asp 
    1145                 1150                 1155             


Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu Pro  Ser Leu Thr 
    1160                 1165                 1170             


Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys Gly  Lys Glu Lys 
    1175                 1180                 1185             


Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser Pro  Lys Lys Gly 
    1190                 1195                 1200             


Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp Thr  Ser Gly Pro 
    1205                 1210                 1215             


Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser Phe  Tyr His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys Ala  Thr His Ala 
    1235                 1240                 1245             


Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser Thr  Glu Lys Phe 
    1250                 1255                 1260             


Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu Ser  Gln Ile Leu 
    1265                 1270                 1275             


Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys Val  Glu Glu Ile 
    1280                 1285                 1290             


Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu Pro  Met Met Ala 
    1295                 1300                 1305             


Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu Phe  Gly Thr Asn 
    1310                 1315                 1320             


Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn Pro  Ser Lys Ser 
    1325                 1330                 1335             


Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser Val  Arg Pro Gly 
    1340                 1345                 1350             


Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr His  Phe Thr Gln 
    1355                 1360                 1365             


Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val Gln  Ala Glu Gln 
    1370                 1375                 1380             


Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu Gln  Lys Val Ser 
    1385                 1390                 1395             


Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr Lys  Asn Arg Ala 
    1400                 1405                 1410             


Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu Phe  Glu Pro Leu 
    1415                 1420                 1425             


Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr Thr  Cys Val Gln 
    1430                 1435                 1440             


Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln Leu  Val Gln Leu 
    1445                 1450                 1455             


Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln Val  Phe Ile Gly 
    1460                 1465                 1470             


Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val Gly  Gln Phe Arg 
    1475                 1480                 1485             


Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe Phe  Leu Val Leu 
    1490                 1495                 1500             


Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile Ile  Gly Ile Pro 
    1505                 1510                 1515             


Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala Ser  Gly Arg Lys 
    1520                 1525                 1530             


Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro Ile  Val His Asp 
    1535                 1540                 1545             


Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp Ala  Gly Lys Glu 
    1550                 1555                 1560             


Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met Leu  Leu Arg Leu 
    1565                 1570                 1575             


Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile Leu  Val Leu Gln 
    1580                 1585                 1590             


Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys Arg  Leu Ser Arg 
    1595                 1600                 1605             


Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala Lys  Gln Gln Met 
    1610                 1615                 1620             


His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu Asn  Thr Leu Phe 
    1625                 1630                 1635             


Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val Asp  Met Leu Leu 
    1640                 1645                 1650             


Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala Ser  Val Ser Thr 
    1655                 1660                 1665             


Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile Leu  Arg Val Leu 
    1670                 1675                 1680             


Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser Arg  Ile Gln Glu 
    1685                 1690                 1695             


Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr Val  Ile Asn Arg 
    1700                 1705                 1710             


Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu Glu  His Ser Glu 
    1715                 1720                 1725             


Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr Phe  Ser Arg Phe 
    1730                 1735                 1740             


Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp Ile  Val Thr Lys 
    1745                 1750                 1755             


Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His Thr  Phe Tyr Cys 
    1760                 1765                 1770             


Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile His  Ile Phe Lys 
    1775                 1780                 1785             


Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala Thr  Arg Leu Phe 
    1790                 1795                 1800             


Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr Leu  Asp Ser Leu 
    1805                 1810                 1815             


Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His Pro  Ala Leu Val 
    1820                 1825                 1830             


Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn His  Thr Asp Tyr 
    1835                 1840                 1845             


Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys Arg  His Ser Leu 
    1850                 1855                 1860             


Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser Gly  Glu Glu Glu 
    1865                 1870                 1875             


Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys Asn  Arg Glu Ile 
    1880                 1885                 1890             


Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp Tyr  Val Cys Gln 
    1895                 1900                 1905             


Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu Ile  Val Asn His 
    1910                 1915                 1920             


Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro Pro  Val Gln Asp 
    1925                 1930                 1935             


Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala Ser  Gly Leu Phe 
    1940                 1945                 1950             


Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu Ser  Thr Pro Thr 
    1955                 1960                 1965             


Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly Ile  His Leu Ser 
    1970                 1975                 1980             


Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp Arg  Leu Leu Cys 
    1985                 1990                 1995             


Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp Ile  Leu Ala Cys 
    2000                 2005                 2010             


Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu Gln  Ser Ser Met 
    2015                 2020                 2025             


Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile Gln  Glu Tyr Leu 
    2030                 2035                 2040             


Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg Leu  Tyr Ser Leu 
    2045                 2050                 2055             


Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp Ser  Leu Ser Pro 
    2060                 2065                 2070             


Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly Asp  Gly His Val 
    2075                 2080                 2085             


Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp Tyr  Val His Leu 
    2090                 2095                 2100             


Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser Ala  Leu Leu Glu 
    2105                 2110                 2115             


Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu Asp  Met Asn Ala 
    2120                 2125                 2130             


Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu Leu  Ala Pro Cys 
    2135                 2140                 2145             


Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly Gln  Lys Ser Ala 
    2150                 2155                 2160             


Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala Arg  Val Ser Gly 
    2165                 2170                 2175             


Thr Val  Gln Gln Leu Pro Ala  Val His His Val Phe  Gln Pro Glu 
    2180                 2185                 2190             


Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys Leu  Asn Asp Leu 
    2195                 2200                 2205             


Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro Thr  Leu Ala Arg 
    2210                 2215                 2220             


Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys Leu  Pro Ser His 
    2225                 2230                 2235             


Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile Val  Lys Phe Val 
    2240                 2245                 2250             


Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu Ile  His Glu Gln 
    2255                 2260                 2265             


Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu Asp  Cys Cys Cys 
    2270                 2275                 2280             


Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val Val  Ser Ser Thr 
    2285                 2290                 2295             


Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr Cys  Val His Phe 
    2300                 2305                 2310             


Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu Gln  Leu Leu Ser 
    2315                 2320                 2325             


Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile Ser  Glu Glu Glu 
    2330                 2335                 2340             


Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys Tyr  Ile Thr Ala 
    2345                 2350                 2355             


Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser Leu  Gln Ser Val 
    2360                 2365                 2370             


Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val Pro  Ala Phe Leu 
    2375                 2380                 2385             


Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu Ala  Arg Leu Pro 
    2390                 2395                 2400             


Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu Val  Trp Lys Leu 
    2405                 2410                 2415             


Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly Thr  Ala Phe Pro 
    2420                 2425                 2430             


Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu Val  Phe Lys Glu 
    2435                 2440                 2445             


Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr Ser  Arg Thr Gln 
    2450                 2455                 2460             


Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val Leu  Val Thr Gln 
    2465                 2470                 2475             


Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro Glu  Glu Asp Thr 
    2480                 2485                 2490             


Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln Ala  Ile Thr Ser 
    2495                 2500                 2505             


Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala Gly  Asn Pro Ala 
    2510                 2515                 2520             


Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys Pro  Leu Lys Ala 
    2525                 2530                 2535             


Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile Ile  Arg Gly Ile 
    2540                 2545                 2550             


Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys Arg  Glu Asn Ile 
    2555                 2560                 2565             


Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro Val  Pro Ser Leu 
    2570                 2575                 2580             


Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His Glu  Lys Leu Leu 
    2585                 2590                 2595             


Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser Met  Ser Tyr Lys 
    2600                 2605                 2610             


Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu Gly  Asn Ser Ile 
    2615                 2620                 2625             


Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu Glu  Glu Glu Glu 
    2630                 2635                 2640             


Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr Ser  Pro Val Asn 
    2645                 2650                 2655             


Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His Ser  Cys Ser Gln 
    2660                 2665                 2670             


Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu Pro  Ser Ser Ser 
    2675                 2680                 2685             


Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu Val  Val Arg Ser 
    2690                 2695                 2700             


Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg Asn  Gln Phe Glu 
    2705                 2710                 2715             


Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg Val  His Pro Ser 
    2720                 2725                 2730             


Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro Ala  Thr Cys Lys 
    2735                 2740                 2745             


Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val Ala  Glu Pro Val 
    2750                 2755                 2760             


Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser His  Leu Pro Ser 
    2765                 2770                 2775             


Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val Leu  Glu Cys Asp 
    2780                 2785                 2790             


Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro Val  Ile Ser Asp 
    2795                 2800                 2805             


Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His Cys  Val Asn Ile 
    2810                 2815                 2820             


His Ser  Gln Gln His Val Leu  Val Met Cys Ala Thr  Ala Phe Tyr 
    2825                 2830                 2835             


Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro Glu  Phe Ser Ala 
    2840                 2845                 2850             


Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser Gly  Ser Glu Glu 
    2855                 2860                 2865             


Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu Arg  Gly Leu Glu 
    2870                 2875                 2880             


Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu Asp  Ala Glu Ser 
    2885                 2890                 2895             


Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val His  Ser Pro His 
    2900                 2905                 2910             


Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr Cys  Met Tyr Thr 
    2915                 2920                 2925             


Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser Asp  Pro Asn Pro 
    2930                 2935                 2940             


Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala Met  Glu Arg Val 
    2945                 2950                 2955             


Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe Pro  Cys Glu Ala 
    2960                 2965                 2970             


Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu Asp  Asp Phe Phe 
    2975                 2980                 2985             


Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly Glu  Phe Leu Ser 
    2990                 2995                 3000             


Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr Val  Val Tyr Lys 
    3005                 3010                 3015             


Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser Ser  Met Val Arg 
    3020                 3025                 3030             


Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr Gln  Arg Ala Pro 
    3035                 3040                 3045             


Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe Phe  Val Ser Ala 
    3050                 3055                 3060             


Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro His  Val Ile Ser 
    3065                 3070                 3075             


Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn Leu  Phe Cys Leu 
    3080                 3085                 3090             


Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu Glu  Glu Leu Asp 
    3095                 3100                 3105             


Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val Ala  Ala Pro Gly 
    3110                 3115                 3120             


Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg Asn  Val His Lys 
    3125                 3130                 3135             


Val Thr  Thr Cys 
    3140         


<210> 10
<211> 13472
<212> DNA
<213> Homo sapiens

<400> 10
gctgccggga cgggtccaag atggacggcc gctcaggttc tgcttttacc tgcggcccag       60

agccccattc attgccccgg tgctgagcgg cgccgcgagt cggcccgagg cctccgggga      120

ctgccgtgcc gggcgggaga ccgccatggc gaccctggaa aagctgatga aggccttcga      180

gtccctcaag tccttccagc agcagcagca gcagcagcag cagcagcagc agcagcagca      240

gcagcagcag cagcaacagc cgccaccgcc gccgccgccg ccgccgcctc ctcagcttcc      300

tcagccgccg ccgcaggcac agccgctgct gcctcagccg cagccgcccc cgccgccgcc      360

cccgccgcca cccggcccgg ctgtggctga ggagccgctg caccgaccaa agaaagaact      420

ttcagctacc aagaaagacc gtgtgaatca ttgtctgaca atatgtgaaa acatagtggc      480

acagtctgtc agaaattctc cagaatttca gaaacttctg ggcatcgcta tggaactttt      540

tctgctgtgc agtgatgacg cagagtcaga tgtcaggatg gtggctgacg aatgcctcaa      600

caaagttatc aaagctttga tggattctaa tcttccaagg ttacagctcg agctctataa      660

ggaaattaaa aagaatggtg cccctcggag tttgcgtgct gccctgtgga ggtttgctga      720

gctggctcac ctggttcggc ctcagaaatg caggccttac ctggtgaacc ttctgccgtg      780

cctgactcga acaagcaaga gacccgaaga atcagtccag gagaccttgg ctgcagctgt      840

tcccaaaatt atggcttctt ttggcaattt tgcaaatgac aatgaaatta aggttttgtt      900

aaaggccttc atagcgaacc tgaagtcaag ctcccccacc attcggcgga cagcggctgg      960

atcagcagtg agcatctgcc agcactcaag aaggacacaa tatttctata gttggctact     1020

aaatgtgctc ttaggcttac tcgttcctgt cgaggatgaa cactccactc tgctgattct     1080

tggcgtgctg ctcaccctga ggtatttggt gcccttgctg cagcagcagg tcaaggacac     1140

aagcctgaaa ggcagcttcg gagtgacaag gaaagaaatg gaagtctctc cttctgcaga     1200

gcagcttgtc caggtttatg aactgacgtt acatcataca cagcaccaag accacaatgt     1260

tgtgaccgga gccctggagc tgttgcagca gctcttcaga acgcctccac ccgagcttct     1320

gcaaaccctg accgcagtcg ggggcattgg gcagctcacc gctgctaagg aggagtctgg     1380

tggccgaagc cgtagtggga gtattgtgga acttatagct ggagggggtt cctcatgcag     1440

ccctgtcctt tcaagaaaac aaaaaggcaa agtgctctta ggagaagaag aagccttgga     1500

ggatgactct gaatcgagat cggatgtcag cagctctgcc ttaacagcct cagtgaagga     1560

tgagatcagt ggagagctgg ctgcttcttc aggggtttcc actccagggt cagcaggtca     1620

tgacatcatc acagaacagc cacggtcaca gcacacactg caggcggact cagtggatct     1680

ggccagctgt gacttgacaa gctctgccac tgatggggat gaggaggata tcttgagcca     1740

cagctccagc caggtcagcg ccgtcccatc tgaccctgcc atggacctga atgatgggac     1800

ccaggcctcg tcgcccatca gcgacagctc ccagaccacc accgaagggc ctgattcagc     1860

tgttacccct tcagacagtt ctgaaattgt gttagacggt accgacaacc agtatttggg     1920

cctgcagatt ggacagcccc aggatgaaga tgaggaagcc acaggtattc ttcctgatga     1980

agcctcggag gccttcagga actcttccat ggcccttcaa caggcacatt tattgaaaaa     2040

catgagtcac tgcaggcagc cttctgacag cagtgttgat aaatttgtgt tgagagatga     2100

agctactgaa ccgggtgatc aagaaaacaa gccttgccgc atcaaaggtg acattggaca     2160

gtccactgat gatgactctg cacctcttgt ccattgtgtc cgccttttat ctgcttcgtt     2220

tttgctaaca gggggaaaaa atgtgctggt tccggacagg gatgtgaggg tcagcgtgaa     2280

ggccctggcc ctcagctgtg tgggagcagc tgtggccctc cacccggaat ctttcttcag     2340

caaactctat aaagttcctc ttgacaccac ggaataccct gaggaacagt atgtctcaga     2400

catcttgaac tacatcgatc atggagaccc acaggttcga ggagccactg ccattctctg     2460

tgggaccctc atctgctcca tcctcagcag gtcccgcttc cacgtgggag attggatggg     2520

caccattaga accctcacag gaaatacatt ttctttggcg gattgcattc ctttgctgcg     2580

gaaaacactg aaggatgagt cttctgttac ttgcaagtta gcttgtacag ctgtgaggaa     2640

ctgtgtcatg agtctctgca gcagcagcta cagtgagtta ggactgcagc tgatcatcga     2700

tgtgctgact ctgaggaaca gttcctattg gctggtgagg acagagcttc tggaaaccct     2760

tgcagagatt gacttcaggc tggtgagctt tttggaggca aaagcagaaa acttacacag     2820

aggggctcat cattatacag ggcttttaaa actgcaagaa cgagtgctca ataatgttgt     2880

catccatttg cttggagatg aagaccccag ggtgcgacat gttgccgcag catcactaat     2940

taggcttgtc ccaaagctgt tttataaatg tgaccaagga caagctgatc cagtagtggc     3000

cgtggcaaga gatcaaagca gtgtttacct gaaacttctc atgcatgaga cgcagcctcc     3060

atctcatttc tccgtcagca caataaccag aatatataga ggctataacc tactaccaag     3120

cataacagac gtcactatgg aaaataacct ttcaagagtt attgcagcag tttctcatga     3180

actaatcaca tcaaccacca gagcactcac atttggatgc tgtgaagctt tgtgtcttct     3240

ttccactgcc ttcccagttt gcatttggag tttaggttgg cactgtggag tgcctccact     3300

gagtgcctca gatgagtcta ggaagagctg taccgttggg atggccacaa tgattctgac     3360

cctgctctcg tcagcttggt tcccattgga tctctcagcc catcaagatg ctttgatttt     3420

ggccggaaac ttgcttgcag ccagtgctcc caaatctctg agaagttcat gggcctctga     3480

agaagaagcc aacccagcag ccaccaagca agaggaggtc tggccagccc tgggggaccg     3540

ggccctggtg cccatggtgg agcagctctt ctctcacctg ctgaaggtga ttaacatttg     3600

tgcccacgtc ctggatgacg tggctcctgg acccgcaata aaggcagcct tgccttctct     3660

aacaaacccc ccttctctaa gtcccatccg acgaaagggg aaggagaaag aaccaggaga     3720

acaagcatct gtaccgttga gtcccaagaa aggcagtgag gccagtgcag cttctagaca     3780

atctgatacc tcaggtcctg ttacaacaag taaatcctca tcactgggga gtttctatca     3840

tcttccttca tacctcaaac tgcatgatgt cctgaaagct acacacgcta actacaaggt     3900

cacgctggat cttcagaaca gcacggaaaa gtttggaggg tttctccgct cagccttgga     3960

tgttctttct cagatactag agctggccac actgcaggac attgggaagt gtgttgaaga     4020

gatcctagga tacctgaaat cctgctttag tcgagaacca atgatggcaa ctgtttgtgt     4080

tcaacaattg ttgaagactc tctttggcac aaacttggcc tcccagtttg atggcttatc     4140

ttccaacccc agcaagtcac aaggccgagc acagcgcctt ggctcctcca gtgtgaggcc     4200

aggcttgtac cactactgct tcatggcccc gtacacccac ttcacccagg ccctcgctga     4260

cgccagcctg aggaacatgg tgcaggcgga gcaggagaac gacacctcgg gatggtttga     4320

tgtcctccag aaagtgtcta cccagttgaa gacaaacctc acgagtgtca caaagaaccg     4380

tgcagataag aatgctattc ataatcacat tcgtttgttt gaacctcttg ttataaaagc     4440

tttaaaacag tacacgacta caacatgtgt gcagttacag aagcaggttt tagatttgct     4500

ggcgcagctg gttcagttac gggttaatta ctgtcttctg gattcagatc aggtgtttat     4560

tggctttgta ttgaaacagt ttgaatacat tgaagtgggc cagttcaggg aatcagaggc     4620

aatcattcca aacatctttt tcttcttggt attactatct tatgaacgct atcattcaaa     4680

acagatcatt ggaattccta aaatcattca gctctgtgat ggcatcatgg ccagtggaag     4740

gaaggctgtg acacatgcca taccggctct gcagcccata gtccacgacc tctttgtatt     4800

aagaggaaca aataaagctg atgcaggaaa agagcttgaa acccaaaaag aggtggtggt     4860

gtcaatgtta ctgagactca tccagtacca tcaggtgttg gagatgttca ttcttgtcct     4920

gcagcagtgc cacaaggaga atgaagacaa gtggaagcga ctgtctcgac agatagctga     4980

catcatcctc ccaatgttag ccaaacagca gatgcacatt gactctcatg aagcccttgg     5040

agtgttaaat acattatttg agattttggc cccttcctcc ctccgtccgg tagacatgct     5100

tttacggagt atgttcgtca ctccaaacac aatggcgtcc gtgagcactg ttcaactgtg     5160

gatatcggga attctggcca ttttgagggt tctgatttcc cagtcaactg aagatattgt     5220

tctttctcgt attcaggagc tctccttctc tccgtattta atctcctgta cagtaattaa     5280

taggttaaga gatggggaca gtacttcaac gctagaagaa cacagtgaag ggaaacaaat     5340

aaagaatttg ccagaagaaa cattttcaag gtttctatta caactggttg gtattctttt     5400

agaagacatt gttacaaaac agctgaaggt ggaaatgagt gagcagcaac atactttcta     5460

ttgccaggaa ctaggcacac tgctaatgtg tctgatccac atcttcaagt ctggaatgtt     5520

ccggagaatc acagcagctg ccactaggct gttccgcagt gatggctgtg gcggcagttt     5580

ctacaccctg gacagcttga acttgcgggc tcgttccatg atcaccaccc acccggccct     5640

ggtgctgctc tggtgtcaga tactgctgct tgtcaaccac accgactacc gctggtgggc     5700

agaagtgcag cagaccccga aaagacacag tctgtccagc acaaagttac ttagtcccca     5760

gatgtctgga gaagaggagg attctgactt ggcagccaaa cttggaatgt gcaatagaga     5820

aatagtacga agaggggctc tcattctctt ctgtgattat gtctgtcaga acctccatga     5880

ctccgagcac ttaacgtggc tcattgtaaa tcacattcaa gatctgatca gcctttccca     5940

cgagcctcca gtacaggact tcatcagtgc cgttcatcgg aactctgctg ccagcggcct     6000

gttcatccag gcaattcagt ctcgttgtga aaacctttca actccaacca tgctgaagaa     6060

aactcttcag tgcttggagg ggatccatct cagccagtcg ggagctgtgc tcacgctgta     6120

tgtggacagg cttctgtgca cccctttccg tgtgctggct cgcatggtcg acatccttgc     6180

ttgtcgccgg gtagaaatgc ttctggctgc aaatttacag agcagcatgg cccagttgcc     6240

aatggaagaa ctcaacagaa tccaggaata ccttcagagc agcgggctcg ctcagagaca     6300

ccaaaggctc tattccctgc tggacaggtt tcgtctctcc accatgcaag actcacttag     6360

tccctctcct ccagtctctt cccacccgct ggacggggat gggcacgtgt cactggaaac     6420

agtgagtccg gacaaagact ggtacgttca tcttgtcaaa tcccagtgtt ggaccaggtc     6480

agattctgca ctgctggaag gtgcagagct ggtgaatcgg attcctgctg aagatatgaa     6540

tgccttcatg atgaactcgg agttcaacct aagcctgcta gctccatgct taagcctagg     6600

gatgagtgaa atttctggtg gccagaagag tgcccttttt gaagcagccc gtgaggtgac     6660

tctggcccgt gtgagcggca ccgtgcagca gctccctgct gtccatcatg tcttccagcc     6720

cgagctgcct gcagagccgg cggcctactg gagcaagttg aatgatctgt ttggggatgc     6780

tgcactgtat cagtccctgc ccactctggc ccgggccctg gcacagtacc tggtggtggt     6840

ctccaaactg cccagtcatt tgcaccttcc tcctgagaaa gagaaggaca ttgtgaaatt     6900

cgtggtggca acccttgagg ccctgtcctg gcatttgatc catgagcaga tcccgctgag     6960

tctggatctc caggcagggc tggactgctg ctgcctggcc ctgcagctgc ctggcctctg     7020

gagcgtggtc tcctccacag agtttgtgac ccacgcctgc tccctcatct actgtgtgca     7080

cttcatcctg gaggccgttg cagtgcagcc tggagagcag cttcttagtc cagaaagaag     7140

gacaaatacc ccaaaagcca tcagcgagga ggaggaggaa gtagatccaa acacacagaa     7200

tcctaagtat atcactgcag cctgtgagat ggtggcagaa atggtggagt ctctgcagtc     7260

ggtgttggcc ttgggtcata aaaggaatag cggcgtgccg gcgtttctca cgccattgct     7320

aaggaacatc atcatcagcc tggcccgcct gccccttgtc aacagctaca cacgtgtgcc     7380

cccactggtg tggaagcttg gatggtcacc caaaccggga ggggattttg gcacagcatt     7440

ccctgagatc cccgtggagt tcctccagga aaaggaagtc tttaaggagt tcatctaccg     7500

catcaacaca ctaggctgga ccagtcgtac tcagtttgaa gaaacttggg ccaccctcct     7560

tggtgtcctg gtgacgcagc ccctcgtgat ggagcaggag gagagcccac cagaagaaga     7620

cacagagagg acccagatca acgtcctggc cgtgcaggcc atcacctcac tggtgctcag     7680

tgcaatgact gtgcctgtgg ccggcaaccc agctgtaagc tgcttggagc agcagccccg     7740

gaacaagcct ctgaaagctc tcgacaccag gtttgggagg aagctgagca ttatcagagg     7800

gattgtggag caagagattc aagcaatggt ttcaaagaga gagaatattg ccacccatca     7860

tttatatcag gcatgggatc ctgtcccttc tctgtctccg gctactacag gtgccctcat     7920

cagccacgag aagctgctgc tacagatcaa ccccgagcgg gagctgggga gcatgagcta     7980

caaactcggc caggtgtcca tacactccgt gtggctgggg aacagcatca cacccctgag     8040

ggaggaggaa tgggacgagg aagaggagga ggaggccgac gcccctgcac cttcgtcacc     8100

acccacgtct ccagtcaact ccaggaaaca ccgggctgga gttgacatcc actcctgttc     8160

gcagtttttg cttgagttgt acagccgctg gatcctgccg tccagctcag ccaggaggac     8220

cccggccatc ctgatcagtg aggtggtcag atcccttcta gtggtctcag acttgttcac     8280

cgagcgcaac cagtttgagc tgatgtatgt gacgctgaca gaactgcgaa gggtgcaccc     8340

ttcagaagac gagatcctcg ctcagtacct ggtgcctgcc acctgcaagg cagctgccgt     8400

ccttgggatg gacaaggccg tggcggagcc tgtcagccgc ctgctggaga gcacgctcag     8460

gagcagccac ctgcccagca gggttggagc cctgcacggc gtcctctatg tgctggagtg     8520

cgacctgctg gacgacactg ccaagcagct catcccggtc atcagcgact atctcctctc     8580

caacctgaaa gggatcgccc actgcgtgaa cattcacagc cagcagcacg tactggtcat     8640

gtgtgccact gcgttttacc tcattgagaa ctatcctctg gacgtagggc cggaattttc     8700

agcatcaata atacagatgt gtggggtgat gctgtctgga agtgaggagt ccaccccctc     8760

catcatttac cactgtgccc tcagaggcct ggagcgcctc ctgctctctg agcagctctc     8820

ccgcctggat gcagaatcgc tggtcaagct gagtgtggac agagtgaacg tgcacagccc     8880

gcaccgggcc atggcggctc tgggcctgat gctcacctgc atgtacacag gaaaggagaa     8940

agtcagtccg ggtagaactt cagaccctaa tcctgcagcc cccgacagcg agtcagtgat     9000

tgttgctatg gagcgggtat ctgttctttt tgataggatc aggaaaggct ttccttgtga     9060

agccagagtg gtggccagga tcctgcccca gtttctagac gacttcttcc caccccagga     9120

catcatgaac aaagtcatcg gagagtttct gtccaaccag cagccatacc cccagttcat     9180

ggccaccgtg gtgtataagg tgtttcagac tctgcacagc accgggcagt cgtccatggt     9240

ccgggactgg gtcatgctgt ccctctccaa cttcacgcag agggccccgg tcgccatggc     9300

cacgtggagc ctctcctgct tctttgtcag cgcgtccacc agcccgtggg tcgcggcgat     9360

cctcccacat gtcatcagca ggatgggcaa gctggagcag gtggacgtga accttttctg     9420

cctggtcgcc acagacttct acagacacca gatagaggag gagctcgacc gcagggcctt     9480

ccagtctgtg cttgaggtgg ttgcagcccc aggaagccca tatcaccggc tgctgacttg     9540

tttacgaaat gtccacaagg tcaccacctg ctgagcgcca tggtgggaga gactgtgagg     9600

cggcagctgg ggccggagcc tttggaagtc tgcgcccttg tgccctgcct ccaccgagcc     9660

agcttggtcc ctatgggctt ccgcacatgc cgcgggcggc caggcaacgt gcgtgtctct     9720

gccatgtggc agaagtgctc tttgtggcag tggccaggca gggagtgtct gcagtcctgg     9780

tggggctgag cctgaggcct tccagaaagc aggagcagct gtgctgcacc ccatgtgggt     9840

gaccaggtcc tttctcctga tagtcacctg ctggttgttg ccaggttgca gctgctcttg     9900

catctgggcc agaagtcctc cctcctgcag gctggctgtt ggcccctctg ctgtcctgca     9960

gtagaaggtg ccgtgagcag gctttgggaa cactggcctg ggtctccctg gtggggtgtg    10020

catgccacgc cccgtgtctg gatgcacaga tgccatggcc tgtgctgggc cagtggctgg    10080

gggtgctaga cacccggcac cattctccct tctctctttt cttctcagga tttaaaattt    10140

aattatatca gtaaagagat taattttaac gtaactcttt ctatgcccgt gtaaagtatg    10200

tgaatcgcaa ggcctgtgct gcatgcgaca gcgtccgggg tggtggacag ggcccccggc    10260

cacgctccct ctcctgtagc cactggcata gccctcctga gcacccgctg acatttccgt    10320

tgtacatgtt cctgtttatg cattcacaag gtgactggga tgtagagagg cgttagtggg    10380

caggtggcca cagcaggact gaggacaggc ccccattatc ctaggggtgc gctcacctgc    10440

agcccctcct cctcgggcac agacgactgt cgttctccac ccaccagtca gggacagcag    10500

cctccctgtc actcagctga gaaggccagc cctccctggc tgtgagcagc ctccactgtg    10560

tccagagaca tgggcctccc actcctgttc cttgctagcc ctggggtggc gtctgcctag    10620

gagctggctg gcaggtgttg ggacctgctg ctccatggat gcatgcccta agagtgtcac    10680

tgagctgtgt tttgtctgag cctctctcgg tcaacagcaa agcttggtgt cttggcactg    10740

ttagtgacag agcccagcat cccttctgcc cccgttccag ctgacatctt gcacggtgac    10800

cccttttagt caggagagtg cagatctgtg ctcatcggag actgccccac ggccctgtca    10860

gagccgccac tcctatcccc aggccaggtc cctggaccag cctcctgttt gcaggcccag    10920

aggagccaag tcattaaaat ggaagtggat tctggatggc cgggctgctg ctgatgtagg    10980

agctggattt gggagctctg cttgccgact ggctgtgaga cgaggcaggg gctctgcttc    11040

ctcagcccta gaggcgagcc aggcaaggtt ggcgactgtc atgtggcttg gtttggtcat    11100

gcccgtcgat gttttgggta ttgaatgtgg taagtggagg aaatgttgga actctgtgca    11160

ggtgctgcct tgagaccccc aagcttccac ctgtccctct cctatgtggc agctggggag    11220

cagctgagat gtggacttgt atgctgccca catacgtgag ggggagctga aagggagccc    11280

ctcctctgag cagcctctgc caggcctgta tgaggctttt cccaccagct cccaacagag    11340

gcctccccca gccaggacca cctcgtcctc gtggcggggc agcaggagcg gtagaaaggg    11400

gtccgatgtt tgaggaggcc cttaagggaa gctactgaat tataacacgt aagaaaatca    11460

ccattccgta ttggttgggg gctcctgttt ctcatcctag ctttttcctg gaaagcccgc    11520

tagaaggttt gggaacgagg ggaaagttct cagaactgtt ggctgctccc cacccgcctc    11580

ccgcctcccc cgcaggttat gtcagcagct ctgagacagc agtatcacag gccagatgtt    11640

gttcctggct agatgtttac atttgtaaga aataacactg tgaatgtaaa acagagccat    11700

tcccttggaa tgcatatcgc tgggctcaac atagagtttg tcttcctctt gtttacgacg    11760

tgatctaaac cagtccttag caaggggctc agaacacccc gctctggcag taggtgtccc    11820

ccacccccaa agacctgcct gtgtgctccg gagatgaata tgagctcatt agtaaaaatg    11880

acttcaccca cgcatataca taaagtatcc atgcatgtgc atatagacac atctataatt    11940

ttacacacac acctctcaag acggagatgc atggcctcta agagtgcccg tgtcggttct    12000

tcctggaagt tgactttcct tagacccgcc aggtcaagtt agccgcgtga cggacatcca    12060

ggcgtgggac gtggtcaggg cagggctcat tcattgccca ctaggatccc actggcgaag    12120

atggtctcca tatcagctct ctgcagaagg gaggaagact ttatcatgtt cctaaaaatc    12180

tgtggcaagc acccatcgta ttatccaaat tttgttgcaa atgtgattaa tttggttgtc    12240

aagttttggg ggtgggctgt ggggagattg cttttgtttt cctgctggta atatcgggaa    12300

agattttaat gaaaccaggg tagaattgtt tggcaatgca ctgaagcgtg tttctttccc    12360

aaaatgtgcc tcccttccgc tgcgggccca gctgagtcta tgtaggtgat gtttccagct    12420

gccaagtgct ctttgttact gtccaccctc atttctgcca gcgcatgtgt cctttcaagg    12480

ggaaaatgtg aagctgaacc ccctccagac acccagaatg tagcatctga gaaggccctg    12540

tgccctaaag gacacccctc gcccccatct tcatggaggg ggtcatttca gagccctcgg    12600

agccaatgaa cagctcctcc tcttggagct gagatgagcc ccacgtggag ctcgggacgg    12660

atagtagaca gcaataactc ggtgtgtggc cgcctggcag gtggaacttc ctcccgttgc    12720

ggggtggagt gaggttagtt ctgtgtgtct ggtgggtgga gtcaggcttc tcttgctacc    12780

tgtgagcatc cttcccagca gacatcctca tcgggctttg tccctccccc gcttcctccc    12840

tctgcgggga ggacccggga ccacagctgc tggccagggt agacttggag ctgtcctcca    12900

gaggggtcac gtgtaggagt gagaagaagg aagatcttga gagctgctga gggaccttgg    12960

agagctcagg atggctcaga cgaggacact cgcttgccgg gcctgggcct cctgggaagg    13020

agggagctgc tcagaatgcc gcatgacaac tgaaggcaac ctggaaggtt caggggccgc    13080

tcttccccca tgtgcctgtc acgctctggt gcagtcaaag gaacgccttc ccctcagttg    13140

tttctaagag cagagtctcc cgctgcaatc tgggtggtaa ctgccagcct tggaggatcg    13200

tggccaacgt ggacctgcct acggagggtg ggctctgacc caagtggggc ctccttgtcc    13260

aggtctcact gctttgcacc gtggtcagag ggactgtcag ctgagcttga gctcccctgg    13320

agccagcagg gctgtgatgg gcgagtcccg gagccccacc cagacctgaa tgcttctgag    13380

agcaaaggga aggactgacg agagatgtat atttaatttt ttaactgctg caaacattgt    13440

acatccaaat taaaggaaaa aaatggaaac ca                                  13472


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
agctcaatgg cggtaactcc                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gcgctgctgg gaaccggccg                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
caggtcgcac tgcctcgcga                                                   20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
agaccagaca ccccctcccg                                                   20


