                         б

<110>  ݿƼ޹˾

<120>  һƱεϸķ

<130>  0141-PA-020

<160>  59

<170>  PatentIn version 3.5

<210>  1
<211>  1110
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-01

<400>  1
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctccgtttct ctgttgttaa acggggcaga      660

aagaagctcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag      720

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg      780

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      840

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      900

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg      960

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1020

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1080

gcccttcaca tgcaggccct gccccctcgc                                      1110


<210>  2
<211>  366
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ¡41D12ɱ

<400>  2
gaggtgcagc tcgtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt gtctactaca tgaactgggt ccgccaggct      120

ccagggaagg ggctcgagtg ggtctcagat attaataatg aaggtggtac tacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca actctaagaa cagcctgtat      240

ctgcaaatga acagcctgcg cgccgaggac acggccgtgt actactgcgc gagagatgcc      300

ggatatagca accatgtacc catctttgat tcttggggcc aggggaccct ggtcactgtc      360

tcctca                                                                 366


<210>  3
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ¡41D12ɱ

<400>  3
caggcagtgg tgacccagga gccttccctg acagtgtctc caggagggac ggtcacgctc       60

acctgcggcc tcaaatctgg gtctgtcact tccgataact tccccacttg gtaccagcag      120

acaccaggcc aggctccccg attgcttatc tacaacacaa acacccgtca ctctggcgtc      180

cccgaccgct tctccggatc catcctgggc aacaaagccg ccctcaccat cacgggggcc      240

caggccgacg acgaggccga atatttctgt gctctgttca taagtaatcc tagtgttgag      300

ttcggcggag ggacccaact gaccgtccta ggt                                   333


<210>  4
<211>  1518
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-02

<400>  4
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcggca gcgactacaa agacgatgac gacaagggtg gctccgaggt gcagctcgtg      120

gagtctgggg gaggcttggt gcagcctggg gggtctctga gactctcctg tgcagcctct      180

ggattcacct tcagtgtcta ctacatgaac tgggtccgcc aggctccagg gaaggggctc      240

gagtgggtct cagatattaa taatgaaggt ggtactacat actatgcaga ctccgtgaag      300

ggccgattca ccatctccag agacaactct aagaacagcc tgtatctgca aatgaacagc      360

ctgcgcgccg aggacacggc cgtgtactac tgcgcgagag atgccggata tagcaaccat      420

gtacccatct ttgattcttg gggccagggg accctggtca ctgtctcctc aggtggcggt      480

ggctcgggcg gtggtgggtc gggtggcggc ggatctcagg cagtggtgac ccaggagcct      540

tccctgacag tgtctccagg agggacggtc acgctcacct gcggcctcaa atctgggtct      600

gtcacttccg ataacttccc cacttggtac cagcagacac caggccaggc tccccgattg      660

cttatctaca acacaaacac ccgtcactct ggcgtccccg accgcttctc cggatccatc      720

ctgggcaaca aagccgccct caccatcacg ggggcccagg ccgacgacga ggccgaatat      780

ttctgtgctc tgttcataag taatcctagt gttgagttcg gcggagggac ccaactgacc      840

gtcctaggta ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      900

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      960

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1020

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1080

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1140

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1200

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1260

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1320

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1380

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1440

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1500

caggccctgc cccctcgc                                                   1518


<210>  5
<211>  1518
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-03

<400>  5
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcggca gcgactacaa agacgatgac gacaagggtg gctcccaggc agtggtgacc      120

caggagcctt ccctgacagt gtctccagga gggacggtca cgctcacctg cggcctcaaa      180

tctgggtctg tcacttccga taacttcccc acttggtacc agcagacacc aggccaggct      240

ccccgattgc ttatctacaa cacaaacacc cgtcactctg gcgtccccga ccgcttctcc      300

ggatccatcc tgggcaacaa agccgccctc accatcacgg gggcccaggc cgacgacgag      360

gccgaatatt tctgtgctct gttcataagt aatcctagtg ttgagttcgg cggagggacc      420

caactgaccg tcctaggtgg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      480

tctgaggtgc agctcgtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      540

ctctcctgtg cagcctctgg attcaccttc agtgtctact acatgaactg ggtccgccag      600

gctccaggga aggggctcga gtgggtctca gatattaata atgaaggtgg tactacatac      660

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaactctaa gaacagcctg      720

tatctgcaaa tgaacagcct gcgcgccgag gacacggccg tgtactactg cgcgagagat      780

gccggatata gcaaccatgt acccatcttt gattcttggg gccaggggac cctggtcact      840

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      900

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      960

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1020

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1080

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1140

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1200

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1260

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1320

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1380

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1440

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1500

caggccctgc cccctcgc                                                   1518


<210>  6
<211>  579
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70

<400>  6
atgccggagg agggttcggg ctgctcggtg cggcgcaggc cctatgggtg cgtcctgcgg       60

gctgctttgg tcccattggt cgcgggcttg gtgatctgcc tcgtggtgtg catccagcgc      120

ttcgcacagg ctcagcagca gctgccgctc gagtcacttg ggtgggacgt agctgagctg      180

cagctgaatc acacaggacc tcagcaggac cccaggctat actggcaggg gggcccagca      240

ctgggccgct ccttcctgca tggaccagag ctggacaagg ggcagctacg tatccatcgt      300

gatggcatct acatggtaca catccaggtg acgctggcca tctgctcctc cacgacggcc      360

tccaggcacc accccaccac cctggccgtg ggaatctgct ctcccgcctc ccgtagcatc      420

agcctgctgc gtctcagctt ccaccaaggt tgtaccattg cctcccagcg cctgacgccc      480

ctggcccgag gggacacact ctgcaccaac ctcactggga cacttttgcc ttcccgaaac      540

actgatgaga ccttctttgg agtgcagtgg gtgcgcccc                             579


<210>  7
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-19 17ָ

<400>  7
gcuggaugca caccacg                                                      17


<210>  8
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-17 17ָ

<400>  8
gugcggcgca ggcccua                                                      17


<210>  9
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-8 17ָ

<400>  9
cgcaggacgc acccaua                                                        17


<210>  10
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-7 17ָ

<400>  10
cauccagcgc uucgcac                                                        17


<210>  11
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-13 17ָ

<400>  11
gaucgccgcg gcgaugc                                                      17


<210>  12
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-18 17ָ

<400>  12
accccaagug acucgag                                                      17


<210>  13
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-4 17ָ

<400>  13
cuacguaucc aucguga                                                      17


<210>  14
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-6 17ָ

<400>  14
uuggucccau uggucgc                                                      17


<210>  15
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-24 17ָ

<400>  15
ggcugcuuug gucccau                                                      17


<210>  16
<211>  21
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Lenti-For

<400>  16
tcaagcctca gacagtggtt c                                                 21


<210>  17
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Lenti-Rev

<400>  17
cctcataaag agacagcaac cagg                                              24


<210>  18
<211>  370
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-01

<400>  18

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu 
    210                 215                 220                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
225                 230                 235                 240 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                245                 250                 255     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            260                 265                 270         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        275                 280                 285             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    290                 295                 300                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                325                 330                 335     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            340                 345                 350         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        355                 360                 365             


Pro Arg 
    370 


<210>  19
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ¡41D12ɱ

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Asn Glu Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Gly Tyr Ser Asn His Val Pro Ile Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ¡41D12ɱ

<400>  20

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Lys Ser Gly Ser Val Thr Ser Asp 
            20                  25                  30          


Asn Phe Pro Thr Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asn Thr Asn Thr Arg His Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Glu Tyr Phe Cys Ala Leu Phe Ile Ser Asn 
                85                  90                  95      


Pro Ser Val Glu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  21
<211>  506
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-02

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        35                  40                  45              


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    50                  55                  60                  


Ser Val Tyr Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
65                  70                  75                  80  


Glu Trp Val Ser Asp Ile Asn Asn Glu Gly Gly Thr Thr Tyr Tyr Ala 
                85                  90                  95      


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            100                 105                 110         


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        115                 120                 125             


Tyr Tyr Cys Ala Arg Asp Ala Gly Tyr Ser Asn His Val Pro Ile Phe 
    130                 135                 140                 


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
                165                 170                 175     


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
            180                 185                 190         


Thr Cys Gly Leu Lys Ser Gly Ser Val Thr Ser Asp Asn Phe Pro Thr 
        195                 200                 205             


Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asn 
    210                 215                 220                 


Thr Asn Thr Arg His Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 
225                 230                 235                 240 


Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp 
                245                 250                 255     


Glu Ala Glu Tyr Phe Cys Ala Leu Phe Ile Ser Asn Pro Ser Val Glu 
            260                 265                 270         


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  22
<211>  506
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-03

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
        35                  40                  45              


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Lys Ser Gly Ser Val 
    50                  55                  60                  


Thr Ser Asp Asn Phe Pro Thr Trp Tyr Gln Gln Thr Pro Gly Gln Ala 
65                  70                  75                  80  


Pro Arg Leu Leu Ile Tyr Asn Thr Asn Thr Arg His Ser Gly Val Pro 
                85                  90                  95      


Asp Arg Phe Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile 
            100                 105                 110         


Thr Gly Ala Gln Ala Asp Asp Glu Ala Glu Tyr Phe Cys Ala Leu Phe 
        115                 120                 125             


Ile Ser Asn Pro Ser Val Glu Phe Gly Gly Gly Thr Gln Leu Thr Val 
    130                 135                 140                 


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val 
            180                 185                 190         


Tyr Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                 200                 205             


Val Ser Asp Ile Asn Asn Glu Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Asp Ala Gly Tyr Ser Asn His Val Pro Ile Phe Asp Ser 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  23
<211>  193
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70

<400>  23

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  24
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8aź

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  25
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  -Flag-

<400>  25

Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser 
1               5                   10                  


<210>  26
<211>  248
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ-(GGGGS)3-ɱ

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Asn Glu Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Gly Tyr Ser Asn His Val Pro Ile Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu 
    130                 135                 140                 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
145                 150                 155                 160 


Leu Lys Ser Gly Ser Val Thr Ser Asp Asn Phe Pro Thr Trp Tyr Gln 
                165                 170                 175     


Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asn Thr Asn Thr 
            180                 185                 190         


Arg His Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Asn 
        195                 200                 205             


Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ala Glu 
    210                 215                 220                 


Tyr Phe Cys Ala Leu Phe Ile Ser Asn Pro Ser Val Glu Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Gln Leu Thr Val Leu Gly 
                245             


<210>  27
<211>  248
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ-(GGGGS)3-ɱ

<400>  27

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Lys Ser Gly Ser Val Thr Ser Asp 
            20                  25                  30          


Asn Phe Pro Thr Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asn Thr Asn Thr Arg His Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Glu Tyr Phe Cys Ala Leu Phe Ile Ser Asn 
                85                  90                  95      


Pro Ser Val Glu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr Tyr Met 
145                 150                 155                 160 


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Asp 
                165                 170                 175     


Ile Asn Asn Glu Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Asp Ala Gly Tyr Ser Asn His Val Pro Ile Phe Asp Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  28
<211>  22
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  TRAC ָ

<400>  28
gagucucuca gcugguacac gg                                                22


<210>  29
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-24sgRNA-6sgRNA-4 sgRNA-18sgRNA-13sgRNA-7 sgRNA-8sgRNA-17sgRNA-19 17ָͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n = acgu

<400>  29
nnnnnnnnnn nnnnnnn                                                      17


<210>  30
<211>  17
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-19sgRNA-17sgRNA-8 sgRNA-7sgRNA-13sgRNA-18 sgRNA-4 17ָͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = cg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n = acg

<400>  30
nnnnnnnnnn nnnnnnn                                                      17

<210>  31
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-66 ָ

<400>  31
ugcgucucag cuuccacca                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-15 ָ

<400>  32
cauguagaug ccaucacga                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  B2M sgRNA-1 ָ

<400>  33
cucacgcugg auagccucc                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  B2M sgRNA-2 ָ

<400>  34
aguagcgcga gcacagcua                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  B2M sgRNA-3 ָ

<400>  35
gccacggagc gagacaucu                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  B2M sgRNA-4 ָ

<400>  36
aaguugacuu acugaagaa                                                    19


<210>  37
<211>  90
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ1

<400>  37
guuuuagagc uaugcuggaa acagcauagc aaguuaaaau aaggcuaguc cguuaucaac        60
uugaaaaagu ggcaccgagu cggugcuuuu                                         90

<210>  38
<211>  80
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ2

<400>  38
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  39
<211>  82
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ3

<400>  39
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uu                                                82


<210>  40
<211>  50
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ4

<400>  40
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuuuuuuu                  50


<210>  41
<211>  56
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ5

<400>  41
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucauu uuuuuu           56


<210>  42
<211>  69
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ6

<400>  42
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

guuuuuuuu                                                               69


<210>  43
<211>  92
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ7

<400>  43
guuuuagagc uaugcuggaa acagcauagc aaguuaaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


<210>  44
<211>  92
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ8

<400>  44
guuucagagc uaugcuggaa acagcauagc aaguugaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


<210>  45
<211>  84
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ9

<400>  45
guuuuagagc uaugaaaaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa       60

guggcaccga gucggugcuu uuuu                                              84


<210>  46
<211>  88
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ10

<400>  46
guuuuagagc uaugcgaaag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gcuuuuuu                                          88


<210>  47
<211>  98
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ11

<400>  47
guuuuagagc uaugcuguuu gaaaaaacag cauagcaagu uaaaauaagg cuaguccguu       60

aucaacuuga aaaaguggca ccgagucggu gcuuuuuu                               98


<210>  48
<211>  102
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ12

<400>  48
guuuuagagc uaugcuguuu uggaaacaaa acagcauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uu                         102


<210>  49
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-19 19ָ

<400>  49
gcgcuggaug cacaccacg                                                    19


<210>  50
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-17 19ָ

<400>  50
cggugcggcg caggcccua                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-8 19ָ

<400>  51
cccgcaggac gcacccaua                                                    19


<210>  52
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-7 19ָ

<400>  52
ugcauccagc gcuucgcac                                                    19


<210>  53
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-13 19ָ

<400>  53
gugaucgccg cggcgaugc                                                    19


<210>  54
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-18 19ָ

<400>  54
ucaccccaag ugacucgag                                                    19


<210>  55
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-4 19ָ

<400>  55
agcuacguau ccaucguga                                                    19


<210>  56
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-6 19ָ

<400>  56
cuuugguccc auuggucgc                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-24 19ָ

<400>  57
cgggcugcuu uggucccau                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-19; sgRNA-17; sgRNA-8; sgRNA-7; sgRNA-13 ; sgRNA-18; sgRNA-4; sgRNA-6; sgRNA-24 19ָͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n = acgu

<400>  58
nnnnnnnnnn nnnnnnnnn                                                    19


<210>  59
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  sgRNA-19; sgRNA-17; sgRNA-8; sgRNA-7; sgRNA-13; sgRNA-18; sgRNA-4 19ָͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = cg

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n = cgu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n = acg

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n = acgu

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n = acg

<400>  59
nnnnnnnnnn nnnnnnnnn                                                    19