                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD38

<130>  1

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  3013
<212>  DNA
<213>  Mus musculus

<400>  1
gcaggctctg acccagtcag ccctgtgctc tcttcctgcc tagcctgggc cagtcttcgg       60

gagcccaatg gctaactatg aatttagcca ggtgtctggg gacagacctg gctgccgcct      120

ctctaggaaa gcccagatcg gtctcggagt gggtctcctg gtcctgatcg ccttggtagt      180

agggatcgtg gtcatacttc tgaggccgcg ctcactcctg gtgtggactg gagagcctac      240

cacgaagcac ttttctgaca tcttcctggg acgctgcctc atctacactc agatcctccg      300

gccggagatg agagatcaga actgccagga gatactgagt acattcaaag gagcatttgt      360

ttccaagaac ccttgcaaca tcacaagaga agactacgcc ccacttgtta aattggtcac      420

tcaaaccata ccatgtaaca agactctctt ttggagcaaa tccaaacacc tggcccatca      480

atatacttgg atccagggaa agatgttcac cctggaggac accctgctgg gctacattgc      540

tgatgatctc aggtggtgtg gagaccctag tacttctgat atgaactatg tctcttgccc      600

acattggagt gaaaactgtc ccaacaaccc tattactgtg ttctggaaag tgatttccca      660

aaagtttgca gaagatgcct gtggtgtggt ccaagtgatg ctcaatgggt ccctccgtga      720

gccattttac aaaaacagca cctttggaag tgtggaagtc tttagtttgg acccaaataa      780

ggttcataaa ctacaggcct gggtgatgca cgacatcgaa ggagcttcca gtaacgcatg      840

ttcaagctcc tccttaaatg agctgaagat gattgtgcag aaaaggaata tgatatttgc      900

ctgcgtggat aactacaggc ctgccaggtt tcttcagtgt gtgaagaacc ctgagcaccc      960

atcgtgtaga cttaatacgt gaaggatctg gatcttagat cacctgtagc ctggactgag     1020

atgaaggggc tcagaagcaa cactggtgga aagctgaaac tgtcagggag aagcctctac     1080

tacagtgtta acaccagaga tggaagaact tcccaattct ctgtgtacta ccaacattca     1140

agaaaaatta ctccataaac cagagttaaa cttctatatt gttatattag tctaactttc     1200

tcatgtggtg cttctgtatt gtttatatat tgcttacatc cttttattcc tcttttaatg     1260

atctctcttt tctctctctc tctctctctc tctctctctc aatgaggctg agaatccaac     1320

ctgagaactt tcatacatgg tggataagcc tatataccac tgagctaaat cctcagcaca     1380

gctgataaca tcatttttgc tgaaaaatgg ccaatcaaac ttcccattag acaaagaaag     1440

tcaaatgtca agtatatcga aatgaatgac cctttttttt ttttatgttt tttcattctt     1500

cccacagata ttcacatggt aaacctgagg tcatagggtc attataggga aggtgctgtg     1560

tgggaactac ccacgtgccc tgtgctttaa tctttaactc aacacatccc tgataacttt     1620

gagcattctt ttcttttctt ttctttcctt ttcttttctt ttcttttctt tttctttttt     1680

ttaaacagaa gaaaatggag tttagagaga taattgattt tcctaaagtc acattcttaa     1740

gatcatggtt acatctagaa ttaaatcagt tctgtcaaag tccacaacat atgatagttt     1800

ttttcttttc cgagctttta ttgccaaatt ggtagtagcc tgtgttgtcg tctagcaaat     1860

gctattgcat tagattgaat ataatagaat ctgaaatgtg atctttatgg aagatcacaa     1920

aactaattac ttgcaccctc tttctcttcc acttcattct tggtgccttt tataggcagt     1980

caagagttaa catatatttg ttgctaatat tggcaattta tgttttctat cctttttttc     2040

ttagatcagt cttgctcaga atcactggtt ttgttatgtt gttgttgttg ctattgttat     2100

tgttcttgtc tttttcaaag ctcaaatctt taactttcct catttattta tttaattgag     2160

ctttagtctt tatttttaga aacatagaaa tttcttctag ctatctggaa tatcttcagt     2220

tttttgaggc aaatgcttag accattgata tttcagtctg ttttctacac atgtacttta     2280

ggattctagg tttctccctg agccctgctt tcgatgtaac actgaatttc tgtatgtctt     2340

tactggttag ttactttgat agtttgtata tgcttgaccc agtgagtggc aggattagaa     2400

ggtatggcct tgctggaata ggtgtgccac tgtgggtgta gtcttaagac ccttacccta     2460

gctgcctgga ggccactatt ccactaacag ccttcaaatg aaaatataaa actctcagct     2520

ctgcctgtgc catgcctgcc tggatgctgc catgctccca ccttgatgat aatggactga     2580

acctctgaac ctgtaagcca gccccaattt gttgtcctta taaaagactt gctttggtca     2640

tggtatctgt tcacagcaga aagaacctaa ctaagacagt taccattcag ttcaaaataa     2700

ttcttgattt tattgttatt tagacatgtg atatttactt ttcaacatct ggagaattgt     2760

ttaggttttt tttgtgtgtg tgtctttagt aggtattaat aaactaaatt gagacaactc     2820

caaagtattt gcttggttta ttgaaaatag cataaacaga gccaggtgct tctgtattca     2880

tgttttgaca ccagtttgtg attgttgaac aatatatctt atttctaaac ttttaaaaag     2940

ctacttaaag acattaactt gctcccttac aatatgttga tggttcagtc cattaaatgc     3000

ttactttgta agt                                                        3013


<210>  2
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Asn Tyr Glu Phe Ser Gln Val Ser Gly Asp Arg Pro Gly Cys 
1               5                   10                  15      


Arg Leu Ser Arg Lys Ala Gln Ile Gly Leu Gly Val Gly Leu Leu Val 
            20                  25                  30          


Leu Ile Ala Leu Val Val Gly Ile Val Val Ile Leu Leu Arg Pro Arg 
        35                  40                  45              


Ser Leu Leu Val Trp Thr Gly Glu Pro Thr Thr Lys His Phe Ser Asp 
    50                  55                  60                  


Ile Phe Leu Gly Arg Cys Leu Ile Tyr Thr Gln Ile Leu Arg Pro Glu 
65                  70                  75                  80  


Met Arg Asp Gln Asn Cys Gln Glu Ile Leu Ser Thr Phe Lys Gly Ala 
                85                  90                  95      


Phe Val Ser Lys Asn Pro Cys Asn Ile Thr Arg Glu Asp Tyr Ala Pro 
            100                 105                 110         


Leu Val Lys Leu Val Thr Gln Thr Ile Pro Cys Asn Lys Thr Leu Phe 
        115                 120                 125             


Trp Ser Lys Ser Lys His Leu Ala His Gln Tyr Thr Trp Ile Gln Gly 
    130                 135                 140                 


Lys Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Ile Ala Asp Asp 
145                 150                 155                 160 


Leu Arg Trp Cys Gly Asp Pro Ser Thr Ser Asp Met Asn Tyr Val Ser 
                165                 170                 175     


Cys Pro His Trp Ser Glu Asn Cys Pro Asn Asn Pro Ile Thr Val Phe 
            180                 185                 190         


Trp Lys Val Ile Ser Gln Lys Phe Ala Glu Asp Ala Cys Gly Val Val 
        195                 200                 205             


Gln Val Met Leu Asn Gly Ser Leu Arg Glu Pro Phe Tyr Lys Asn Ser 
    210                 215                 220                 


Thr Phe Gly Ser Val Glu Val Phe Ser Leu Asp Pro Asn Lys Val His 
225                 230                 235                 240 


Lys Leu Gln Ala Trp Val Met His Asp Ile Glu Gly Ala Ser Ser Asn 
                245                 250                 255     


Ala Cys Ser Ser Ser Ser Leu Asn Glu Leu Lys Met Ile Val Gln Lys 
            260                 265                 270         


Arg Asn Met Ile Phe Ala Cys Val Asp Asn Tyr Arg Pro Ala Arg Phe 
        275                 280                 285             


Leu Gln Cys Val Lys Asn Pro Glu His Pro Ser Cys Arg Leu Asn Thr 
    290                 295                 300                 


<210>  3
<211>  5620
<212>  DNA
<213>  Homo sapiens

<400>  3
gcagtttcag aacccagcca gcctctctct tgctgcctag cctcctgccg gcctcatctt       60

cgcccagcca accccgcctg gagccctatg gccaactgcg agttcagccc ggtgtccggg      120

gacaaaccct gctgccggct ctctaggaga gcccaactct gtcttggcgt cagtatcctg      180

gtcctgatcc tcgtcgtggt gctcgcggtg gtcgtcccga ggtggcgcca gcagtggagc      240

ggtccgggca ccaccaagcg ctttcccgag accgtcctgg cgcgatgcgt caagtacact      300

gaaattcatc ctgagatgag acatgtagac tgccaaagtg tatgggatgc tttcaagggt      360

gcatttattt caaaacatcc ttgcaacatt actgaagaag actatcagcc actaatgaag      420

ttgggaactc agaccgtacc ttgcaacaag attcttcttt ggagcagaat aaaagatctg      480

gcccatcagt tcacacaggt ccagcgggac atgttcaccc tggaggacac gctgctaggc      540

taccttgctg atgacctcac atggtgtggt gaattcaaca cttccaaaat aaactatcaa      600

tcttgcccag actggagaaa ggactgcagc aacaaccctg tttcagtatt ctggaaaacg      660

gtttcccgca ggtttgcaga agctgcctgt gatgtggtcc atgtgatgct caatggatcc      720

cgcagtaaaa tctttgacaa aaacagcact tttgggagtg tggaagtcca taatttgcaa      780

ccagagaagg ttcagacact agaggcctgg gtgatacatg gtggaagaga agattccaga      840

gacttatgcc aggatcccac cataaaagag ctggaatcga ttataagcaa aaggaatatt      900

caattttcct gcaagaatat ctacagacct gacaagtttc ttcagtgtgt gaaaaatcct      960

gaggattcat cttgcacatc tgagatctga gccagtcgct gtggttgttt tagctccttg     1020

actccttgtg gtttatgtca tcatacatga ctcagcatac ctgctggtgc agagctgaag     1080

attttggagg gtcctccaca ataaggtcaa tgccagagac ggaagccttt ttccccaaag     1140

tcttaaaata acttatatca tcagcatacc tttattgtga tctatcaata gtcaagaaaa     1200

attattgtat aagattagaa tgaaaattgt atgttaagtt acttcacttt aattctcatg     1260

tgatcctttt atgttattta tatattggta acatcctttc tattgaaaaa tcaccacacc     1320

aaacctctct tattagaaca ggcaagtgaa gaaaagtgaa tgctcaagtt tttcagaaag     1380

cattacattt ccaaatgaat gaccttgttg catgatgtat ttttgtaccc ttcctacaga     1440

tagtcaaacc ataaacttca tggtcatggg tcatgttggt gaaaattatt ctgtaggata     1500

taagctaccc acgtacttgg tgctttaccc caacccttcc aacagtgctg tgaggttggt     1560

attatttcat tttttagatg agaaaatggg agctcagaga ggttatatat ttaagttggt     1620

gcaaaagtaa ttgcaagttt tgccaccgaa aggaatggca aaaccacaat tatttttgaa     1680

ccaacctaat aatttaccgt aagtcctaca tttagtatca agctagagac tgaatttgaa     1740

ctcaactctg tccaactcca aaattcatgt gctttttcct tctaggcctt tcataccaaa     1800

ctaatagtag tttatattct cttccaacaa atgcatattg gattaaattg actagaatgg     1860

aatctggaat atagttcttc tggatggctc caaaacacat gtttttcttc ccccgtcttc     1920

ctcctcctct tcatgctcag tgttttatat atgtagtata cagttaaaat atacttgttg     1980

ctggtactgg cagcttatat tttctctctt ttttcatgga ttaaccttgc ttgagggctt     2040

taacaattgt attacttttt caaagaacta agctttagct tcattgattt ttttctattt     2100

aattgggttt tgctcttctc tttagcattg gaaacataga aatgctttct gatttctttg     2160

ggtagattta cgtattcagc ttcttgagat ggaagtttag atcactgatc cttcagcttg     2220

ttttcttttt tgtatacata gattttagga cgatatattt tcccttgagt tctgctttag     2280

ctgcagctct tatgttttga tatgcctctc tttattatcc ttcagttaaa aatatctttc     2340

aattcattgt tatataaaaa tatgtgccta gtttttaaca tctggagatt ttctagtttt     2400

gaaaaaaaca taagccaggc atggtggctc acacctgtat ccccagcact ttgggaggcc     2460

gagacgggag gatcgcctga gctcaggagt ttttacacca gcctgggaat aacagtgaga     2520

cattatctcc aaaaaaatta cctgggtatg gtgttgtgca cctgtagtcc cagctactct     2580

ggagactgag gtgggaggat tgtttgagct tgggaggttg aggctgcagg gagctgtgat     2640

cacaccactg cactctggcc tgagtgacag attgagaccc tgtctcaata aaagcaaaaa     2700

taaagaaaat aaaccatatg tgttgaacaa aggattaata aattaatttg agactccttc     2760

agggaatgac cacaatttat tgaaaatagc ctaaatgttg gagtcaggca tttctggatt     2820

catattttga catcatgctg tcatcttgaa caaaatgcct aacctttctg aacttcaact     2880

tccttgccac tcaaataagg attacaaaac ttaaaatgtg gtaagtacta aagacgacag     2940

caaaaattga gtccagcaca gagcttccta aataagcaag cactcaacag agttggttcc     3000

tttcttcctc ccctgcttga caatccagtt tcccacagga gcctttgtag ctgtagccac     3060

catggtcagt ccagggattc ttcactagcc ccttctcccc tggcagacat ccttgtggga     3120

gtttagtctt ggctcgacat gaggatgggg gtttgggacc agttctgagt gagaatcaga     3180

cttgccccaa gttgccatta gctccccctg cagaatgtct tcagaatcgg ggcccggtca     3240

gtctcctggg tgacctgctg ttttcctctt aagatccttt ccactttggt tgctgctttc     3300

gggactcatc gagtccttgc tcaacaggat accccttgaa gtggctgcct gggccacatc     3360

cccttccaaa caagaaatca aaatattaga aatcaatttt tgaaatttcc cctaggaaga     3420

ctcatttgag tgttcaagtt cagagccagt ggagacctta ggggagggtg gtcacaagga     3480

ttttgcacag tgctttagag ggtcccaggg agccacagag gtggtgaggg gctgggtgct     3540

cttttctccg tgcatgacct tgtgtgtcta tcttcattac cacaatgcct catctctacc     3600

tcctttcccc ctgtagttcc aacgtgggta tctttgccat ctctggcccg aaggactttc     3660

tgacctacat gtataaatac cccctcacaa tatatattac ttttcctata agtgacttct     3720

ctactggatt actggttgct catacacctc atattttact cgtaaatcta ctactccctg     3780

tctgcctact ccattctcat ttgctgtaga aaattctctt accatcccaa ctttcaccca     3840

ccatcatgct tacccaaagg ctgtgggaat gacctgggcc ctaatgcccc ttttctaaat     3900

tcctaaggct caccattttc ctattgtaat ggttcttgac cttataatgt ttgaggcacc     3960

ttttcaaata tagtcctttg atttcagact gaatacttga aaggacacac acacacatac     4020

gtaagtgcat atgactgcat acacccacac acacacacgt gcctgtatac agtcatatga     4080

tacatacaca aacacacgca cacaagcctg catacatcat atgccaacag tggggatatg     4140

ttctgagaaa tgcatcatta gatgattttg tcattgtgtg aacatcatag agtgtactta     4200

cactaaccta gatggtctaa cctactacac acccaggcta catggtatca cctattcctc     4260

ctaggctaca agcctgtaca gcgtgtgtct gtactaaatg ctgtgggcaa ttttaacctg     4320

atggtaaatg tttgtgtatc taaacatatc taaacataga aaaggtacag taaacatgca     4380

gtattataat cttatgagac cgtcatcata tatgtggtcc actgtttggg ccatcattgg     4440

ctgaaaagtg gttatgcgac acatgactgt atatatactt tcctgttaca acaacagtgt     4500

ctctcaatcc acagtaattg cagcatccag taggtcttac tttagccctg agtcaccatt     4560

tgtgtcaacg tgtttagtgc catgtccacg tctctcatgt aactggcaga gctatcaaat     4620

attttggcaa aacacattgt ttctttggct ttgccttggt aactttctgt gccttttgta     4680

gctcttgttt ggaagaagct caacccatgt ctgcacactg tgatacaagg gggacagcat     4740

cgacatcgac ttacttcttg gtgccttatt cctccttaga acaattccta aatctgtaac     4800

ttaagtttct caggaagatt ccatactgca cagaaaactg cttttgtggg tttttaaaag     4860

gcaagttgtt atatgtgctg gatagttttt aagtatgaca taaaaattgt ataaagtaaa     4920

atattaaaat acacctagaa tactgtataa ctttaagtca ttttatcaac acattgctaa     4980

tccagatatt ttcccgcagt ttttctttga ataacagagc aattaattta cttttactat     5040

gaagagtcat cattttagta tgtattttaa gcaatccacc aagaactcag taggcagctg     5100

agaggtgctg cccagagaag tggtgattag cttggcctta gctcacccac acaaagcaca     5160

acaggctttg aactattccc taacggggca tttattcttt tttttttttt tttttgggag     5220

acggagtctc gctgtcgccc aggctagagt gcagtggcgc gatctcggct cactgcaggc     5280

tccaccccct ggggttcacg ccattctcct gcctcagcct cccaagtagc tgggactgca     5340

ggcgcccgcc atctcgcccg gctaattttt tgtattttta gtagagacgg ggtttcaccg     5400

tgttagccag gatagggcat ttattcttga acttgattca gagaggcaca cattaccatt     5460

ctctaatcag aatgcaagta gcgcaaggcg gtggaaacta tggaattcgg aggcaggtga     5520

tgcattgggc gagtttatta acatctgtga ctctctagtt tgaaatttat ttgtaacaga     5580

caaaaatgaa ttaaacaaac aataaaagta taataaagaa                           5620


<210>  4
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  5
<211>  1349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP STOP sequence

<400>  5
attaagggtt ccggatcctc ggggacacca aatatggcga tctcggcctt ttcgtttctt       60

ggagctggga catgtttgcc atcgatccat ctaccaccag aacggccgtt agatctgctg      120

ccaccgttgt ttccaccgaa gaaaccaccg ttgccgtaac caccacgacg gttgttgcta      180

aagaagctgc caccgccacg gccaccgttg tagccgccgt tgttgttatt gtagttgctc      240

atgttatttc tggcacttct tggttttcct cttaagtgag gaggaacata accattctcg      300

ttgttgtcgt tgatgcttaa attttgcact tgttcgctca gttcagccat aatatgaaat      360

gcttttcttg ttgttcttac ggaataccac ttgccaccta tcaccacaac taactttttc      420

ccgttcctcc atctctttta tatttttttt ctcgagggat ctttgtgaag gaaccttact      480

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata      540

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga      600

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc      660

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt      720

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc      780

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca      840

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct      900

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc      960

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     1020

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     1080

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     1140

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     1200

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     1260

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg acatggtaag     1320

taagcttggg ctgcaggtcg agggaccta                                       1349


<210>  6
<211>  3936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  6
gttatacagt gaaatgttgt tcagccttta aaagggagga aatttaatac atacgtggag       60

gtttgaatgg gaatgacccc cacaggctca aatatgtgaa tttttggttt ccagttgaac      120

tatttaggaa tgactgggaa gtgtggcctt attggaggcg tgtccctggg agtgggtttt      180

aatgtttcaa aagtccatgc cagactcaga ctccccccca caaacacacc cccaccaccc      240

gctccttgca gattagaatg tgcattctta gttactgctc cagcgtgatg ctctctgtcc      300

tctgagactc tccctctgaa accctaagca agctcccaat taaaagcttt cttctatcag      360

ctgctttggt catgatgtaa cctgatcata gcaggagcga ccctaattaa gatgtaatat      420

agctgggaac atcatgctaa gtaaaattag ccatttacaa agattccagg tttgtgagat      480

gcctatcaga ttgaaggaaa tagaaagaat tgtggtagcc agggactggg taaaggaggg      540

gtggggtgtt aatacggatg agttacaaac atcctgacta tttacctgga cacttaaaca      600

gagtcaagca gaaggtgcat ctcagtggta gagcacttgc ctagcatgtg tgatactgta      660

tttagttcct agtactaaac aaaacaaaac aaaacaaaac aaaacaaaac aaaacaaaac      720

aaaacaaaac aaaacaaaac aaaactaccc agtactgtta ggtgtcatag tcccaaaact      780

cataaattct gttattataa ccaaagtaga gtttgcatct tgatgattgc aaactaaaga      840

caagcacagc tgagaaataa gatcagagaa agagttgctg caagcagcag gctcaagaag      900

aaaagatagt agacactttt gaggcatgct taggtaaaaa ttgtgaagca tatttttgca      960

ggattacagt ggtggatgag aacaattttg ggggtgctca ccttgaatca taaagatggt     1020

aaccagtatc acttggcatg ctcaactgtc tttaaagaaa gaaaagtttt agctggaaaa     1080

aggaaaggat attttaaatg tcttactgta gaactttgcc cctaaaagtt agatcttaac     1140

attattttta atttgttaca aggtaaaaaa aattcaaata catagagaaa tttaaaaagt     1200

attagaaaac aaaacaacaa caacaataac aacaataaac gaacaaaaca aaacattatt     1260

tcctggagca gccaggaaaa agacacctaa gtgcccagag ctactcccct gagtgaatat     1320

gtgaagaaca ggggaaagag ggagaagaga gagtacttag tggagagaca gaagagagga     1380

gggtggagct gagcaaatca tgtactgtag agagaagtgg aactggatag cagttagaaa     1440

caggcagaca tgaggagcca tggtgatgtc tgagcccggg tgctaccaag ggccgtgtct     1500

gcttctgtgg cactgctcca gccagagtct gtgctgatgt ctgtggccag agttaacacc     1560

aaagaccatg aggatgtctc tggcatgggc tgccacttaa ggccctgttg atgtccaagc     1620

actatacaag gctggctctg cctcttgcct aggcaccatg ggagagctgg ctctggtgct     1680

ggggatgctg aagagctggt cccagtagga tgagtgtggg agagctggcc ctgtgtccct     1740

caccaaatgc agcactcaga tccccacatc tcttcccctg ggcagcaccg tataactggt     1800

cgtggtaatg agagcaaggg tgagtggcca gagggcatgt gagcaggaga gctggacctg     1860

cccctggctt ggttaaagta ggagagttgg tcccagtggt acatgtatgg gagagctggt     1920

gagctgacca actcagtttc cacctaggcc cagatccagg ggtctgagtt ggcccaccag     1980

aacatccacc ccatctatga actgctggag caaatgaaga ggctggtcct gcagatcccg     2040

agctgtgggc actccatgac acagggtgac aacaggataa ctgagaagag ttccagtgag     2100

ggtccaatat tgatgatgtg acaaaagcta gaggctttgg gaaagaccaa tcaatgactt     2160

attgcaatga acatttgcaa ggaaagatgt gtggacaaat gcgtatactg tggtatgtgc     2220

catgacaggc ggcaacttcc acagcaagat ttttatttaa ttcattttat tttttgttca     2280

cttttgggta gggggaggct gccggactga agggtaaaat gggtgggttt ggaatgcatg     2340

gtgtgaaatt cacaaaggac caataatttt tttttaattt taaaaactgt acttataatg     2400

tatgcaagat gtttttgtta ttctctgcaa attaccaact cttccaagaa tcaagtcttc     2460

caagtcatgt tcagcagtac tactccagtc tcctctcctg agcagacagc cctcctccag     2520

tgggtatctt gaatctttat tacttcttgt actggaatat aagacctaag agaagcatag     2580

aaataatttg tgaaggacgt gagtttcagc acttaaataa gagtttgctg atgagaaggt     2640

ctgctgtgtg gcagggtctc agggcaggat aactgctctt tcccaccacg cttccagaag     2700

tggaaaatgt tctctccttc ttccatcttc ttctgtttca agtcctgcag atgctccaaa     2760

ggaaagacgt agagattttt atgacggttg ggacttagaa cagagagttc ttgagaaggc     2820

cactgcatta attaccagaa agaaaacata aaccctggaa gccgggaagc cgccaaacgt     2880

ctattttctc aattgcctgt gatggtactc tataaatttt gattgacact aaagtacatg     2940

atgtcatcac ttttcctttt tatgtatgta aacggtacgg aaggagaggg ccctaatggt     3000

ttcctggcat cgttttcaaa ggcaggtgct gatgaactta agcttctcag tctagactct     3060

ggaaagaaac cccatcaaac ctttcacatt ttcatttgta tcccctgatt ctcaacccga     3120

actagggtca gaactgcctg gggtgggggt gggggtgggg tggaagtggg aggtatgaat     3180

gccactgatg atcccgccca acattaccaa gcccacctgc agtaacccta cctacttaaa     3240

gttttagtct gacacagagt aattggacat atttatgagt acaatgtggc atttggccta     3300

tgtatacact gtataaagaa cagtgacaga cagctctatc gcctcaggtg ctcatgactt     3360

ctctgtgttg ggaacattcg gtcctctcta cttgctgttt tgaaacattg cccttactgg     3420

gggtactaaa gaaccttaag gacttttttt atacaaggtg tagtatgaga cagaaaacgc     3480

tggtgtcttc ctattttctt cttaatgtta ttagatgctt gggtcatttt aatttcacag     3540

agcctcagcc tcaggtaatt ttcatctcac agggacattt tacacagcta ataggatggt     3600

gtcaagaact gactgcccct gggtatatga ttccagatga agggtatttc ttgttgctat     3660

ctatgttcca aaaatatttt ttaaactttt tcaatgtctt tctttttttc ttttatttat     3720

tttttttata tgttcctaag attgatattt attttacatg tagagttgtt ttgtctgtag     3780

atatgttcat gcaccatgta tgtgcagtga ctgtggaagc cagatggagg tgttagctct     3840

ggaaactgaa cacactgttg ggagccaccg tgagccatct ctccagactc ttcaaaaata     3900

tttttaaaat ctgttttcca tctttcattt tataga                               3936


<210>  7
<211>  5392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  7
taagacatcc ccaaatccag tctctccctc actttccctc tctacatcct tcctgttctc       60

cccttttcct gcctcttcca ctttcctctt ttccctcctc cctctccact ttcttctttc      120

tcttctgcac ttttggcaag aaatctcctc cttaaccttt atatatgtat ttacacacac      180

acacacacac acacacacac acacacacgt tatatattct tgaacataac tctaagtcat      240

ttttttaaaa aaatttaaat taaaattata tatattttta tctgtacaga gtaatattgg      300

atataaatag acatagtgaa cggattgtta tctgtgagct atttaacatg gacaactttg      360

ggtaccatct taaggtgatc tctttctttc cccttcatag ccagtgatga tctatttgcc      420

tagagagcca tctgtgcatc tcccctcaca ctgcctttta gcaccatcac accctctcca      480

tcctgctggg aatgctataa ggttttactg gtcactcttt accctcctag gtcagtctcc      540

atctgacacc atagtttttc tcagagtgaa aatgggatga tgtcgatctc cctctagaac      600

ctaacaatct ctcttttgac tctaggctaa tggtctaaag acctgacctc tgtgtttcag      660

atgcctcacc ttctcattcc cttctccatc ctcttttctg atcaaagctc atcatggctc      720

tttgcctttg caccgtgcca taggcacaag gtgcccttct ctttagagtc tgtctgaaga      780

cagtgattct tcttcaaagt aaatttcaac gtgaatctgt ctctgattat ttgacttcac      840

tacatcacat gtcctatgag gcagggctcc cacctgattc aaccctctat ctccagaacc      900

taaccttcag taaatgttta tatatatatg tgtgtgtgtg tgtgtgtgtg tttatatata      960

tatgtatata tatatgtata tatatatata tatgcaaata accttgagaa cagtgtcata     1020

gaaaccatgc ttctactcta tactttgcac cacactaagg gctaaacctg ttttggtagg     1080

gttgactata gaaagcctga gatcacctga gcccccaaat ttatggaggt tgaaaaggaa     1140

actctccata aaagagaatt gccaggaatc agaggactat ctgggggaaa gtgtcttctt     1200

cccgaaaagg cctggccttc tccctaagtg ttcctggact ccaggggagt gagaggggcc     1260

ggtgtcttta gggtgcactt ttgttgccat ttcccagaat ggtgagtcaa aacccatcac     1320

agtgttcctg tctgggatct ggacggggag gtaaagagtt ggaaggaaat caggggacac     1380

ttacttaaat tgggttgagc tgtgtccatt ctccagcctc tgtcttggca cagatgctgt     1440

tggaaagttc tcctatgggg attggacagc caagaacgga gcccaaaggt acatttcctt     1500

tccatttaac tgttttctat aaacgatgtg ttttagatat gaactatgtc tcttgcccac     1560

attggagtga aaactgtccc aacaacccta ttactgtgtt ctggaaagtg atttcccaaa     1620

aggtaagtca caaatagtta aattctagag ttttcactga agatactgtt cagtccatga     1680

ctggttgact tctggccctt tgggtggggg gtacagatga ttttaggtgt aaaagtatga     1740

aaggaaatca tgccagaaga tttttctaca caacttcaga acacccagga aggcttggga     1800

gctcagggga agaaacctaa cccagtgagg aggtaacact cactggctgt gtctaccagg     1860

atgctaggct tggcttagtc ctgggaccca ggtattgact tgatttctgg aacagtctta     1920

ataattggca tttgtagacc acttgatgtg tgtccaactc tttgcaggag ttaagaactc     1980

tagcctcaca acagccatat gaaacaccat caatatcacg actacttgta aaaatctttt     2040

ttaaaatttg tttaccttta tttttatatg aattggtgtt tttgcctgca tgtctgtcta     2100

tgtgagagtg tcagatcttg gagttacaaa ctgccatatg ggtattagga tttgaaccca     2160

ggttctctgg tagatctgtc agtgccttta actgctgcac tatatttcca acccccaaaa     2220

ccaattttct tagacattct gatcagtttc cttatttcat cttcaccaaa tggaaattaa     2280

cacataccta gtctagatag ctattggtgc attcaaataa aatatcacta gcttgttaag     2340

taatggaacc cacctacaca acaaatgttt attgaagact tactgcatgt tttaaaaact     2400

caaagacgct gtatattttt gtttgctcgc ttttacagag aatgttttcc atttgtgtta     2460

tcactttggg atatgtttta cagccacatc atctctgaaa ccccctacag cagttcatgt     2520

tttatataaa ctaaatgctt ccttgtatca catctcagcc ttggtaccaa ggctaagatg     2580

ctgagggtga ttggaggcac cttggcttct gagacactgt gcacctgtac cttgttctag     2640

gatctctttg aggaagacaa acaaactagt ccctcttttt gacaataagg atggttcttc     2700

ttacaggttt gaattcccag atcaccttgt tgctaagttg tgtgaccttg aggccaacgg     2760

tgccaatgct tactttgtgt cagaggactt gtgagaattc tcctttatag ggttcaggac     2820

tcttctgggt cagtgcttaa tgattaatca taaggagtag gacttggtcc ctctgtggtt     2880

acacaagcac cactggactt cataataaag ctctgaatct atctgtagtg tagaagtcac     2940

ccgcagagta aagtgcaggt tccccaacaa agtacaaggc catctatgaa ctgaatattc     3000

aatatcgact gcaactttcc ccacaaacta ctgttctcct aaaccaaggg ccccttccag     3060

tcacagcttc accagtggag tcctgaccgc tctttgggac gtgggttctg tttgctatac     3120

agcactttct tggtctttcc tagtgtccag tgcagagtat cttcttttct cctgtcatcc     3180

ttttcatccc tggaatttta ctgagtaaaa catacctgtg tcatgcacta ggtataaagc     3240

actgaaagtt ctagaagcac ataggaatcc aagctctttg ttctcacaaa gctcttcgta     3300

ctgacggcta aaactgttca acccgccata acaatgaaat gttgttaagt aatgtgcaca     3360

gatgtcgtgg aaggagaccc acgtcccaga ggtctgtctc caaaggaagc tgaacagtac     3420

tccgttcaca tggtgacctc cagtgcttag cagacctccc agctgaaagt tggttgcatg     3480

aagaaataaa actccttgtt caaccatgtt cttttattca agcaccacac tccctccttc     3540

tttatgcctt tctagagcct caggatcact gcctcttacc tgggcttccc tttctacagt     3600

gttcccctaa attgtccacc ttacttctgc taaataagat gtagcatcta cagaacatga     3660

taccaagtga gtgctttcat tcatgcaaat tgccatggct gcattaagaa ttcatacaaa     3720

gtaaattctt cctgtggctt agactattgg atagattcac cattcttgta ctagaactag     3780

ggaggctatt ctctctccct ctctagttag tactaagtac tctttggatg gaattgctga     3840

agaataatga tgaacttcct tttcttcctc ctcttcttcc tcttcctcct ctttctcctc     3900

ctcctcctct tcctcttctt ccttctcttc ttggttttgg tctttgacag ggtttctctg     3960

tatagctttg gctgtcctgg acatcactct gtagaccagg ctactccaaa ctagcagaga     4020

tccaaccacc tgcctttgcc tcccaagtgc tgcaatcaaa ggcatgtgtc accactcagt     4080

ctggctgacg gacttctttt ttaagtttgc agaagatgcc tgtggtgtgg tccaagtgat     4140

gctcaatggg tccctccgtg agccatttta caaaaacagg tactcatttc ctttctttgt     4200

gcaagggtta attatcacag ttaccatagt ctcctgatgg acatggcatt cctagaaagg     4260

atgtactttc catgtttcat atcagtcctg aagtgctgag cttttaaaag ggaaagctta     4320

tggattcgct cctttctggg tcaatgtttg gtctggttca tctaagatcc tccaaagttc     4380

ctaaaggcca ttgcaggttc ccagtcattg cccttgactt tttgaggtct cacataattt     4440

tcttagcttc cttccccctg cattctatgc tctcatttca tcgatactgt ctaccctgca     4500

tctacccgtc tccctgttag catcctcacc atggctctct cctgtgtgaa gagcaggaat     4560

cccacgtcat tggaacatca gaaaccatgc agggctgtga tcctcctcct cctcttttgg     4620

aagtgttgcc agcaaagtcc tgtagtgata taatggtgaa gacaccagag gtccttatac     4680

atactatatg tgaccttgtg caggcatcta gcctctaggt tgaggatgca tagaaagaaa     4740

ctgagataaa gtgtgaacag tgctgcactc catgcctatt gaaaattctc tagtacatat     4800

tagctttttt ttttcttttt catttaatcc tcagggctga gttggtccac actcaagcct     4860

tccttctctg gcctccttct cgccttagtt tctatcatca tcatggtctt gttctctaat     4920

ctttctctga tgagaatgct tctaaaaatg agagcacata ttaattttct tcaggcactg     4980

tagataccct caattaattg ttcctttctt ctgctttagt atttagtatt ataaagccac     5040

atttaccttt tttccttctt ctggaccttt ttttgggggt ggggtggggg gggctttggg     5100

tgaaagtgct ggtgttcaaa atctcaccct ctgatgttgg agacccaagt ccttgcctca     5160

ggatgggtag ctgtccacac taacaagaaa ggatctagaa agatgttgtt gaatggacag     5220

tctctgtttc taactagctc tctggtaatg ctactctttg agcagcaagt atttttttaa     5280

tgtatcagtc agcatcgatg tacagttaaa actcttatct tgaaaatctc ataaccaaga     5340

gtcatgttga aagaggaaca gtgggaagca agggaggttc tgttcaatcg tg             5392


<210>  8
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the nucleotide sequence 322-990 of NCBI accession number 
       NM_001775.4

<400>  8
catgtagact gccaaagtgt atgggatgct ttcaagggtg catttatttc aaaacatcct       60

tgcaacatta ctgaagaaga ctatcagcca ctaatgaagt tgggaactca gaccgtacct      120

tgcaacaaga ttcttctttg gagcagaata aaagatctgg cccatcagtt cacacaggtc      180

cagcgggaca tgttcaccct ggaggacacg ctgctaggct accttgctga tgacctcaca      240

tggtgtggtg aattcaacac ttccaaaata aactatcaat cttgcccaga ctggagaaag      300

gactgcagca acaaccctgt ttcagtattc tggaaaacgg tttcccgcag gtttgcagaa      360

gctgcctgtg atgtggtcca tgtgatgctc aatggatccc gcagtaaaat ctttgacaaa      420

aacagcactt ttgggagtgt ggaagtccat aatttgcaac cagagaaggt tcagacacta      480

gaggcctggg tgatacatgg tggaagagaa gattccagag acttatgcca ggatcccacc      540

ataaaagagc tggaatcgat tataagcaaa aggaatattc aattttcctg caagaatatc      600

tacagacctg acaagtttct tcagtgtgtg aaaaatcctg aggattcatc ttgcacatct      660

gagatctga                                                              669


<210>  9
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the human CD38 gene sequence 
       and the mouse CD38 gene locus

<400>  9
aatattttta aaatctgttt tccatctttc attttataga catgtagact gccaaagtgt       60

atgggatgct ttcaagggtg                                                   80


<210>  10
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the Neo cassette and the 
       downstream of the loxP STOP sequence

<400>  10
gacatggtaa gtaagcttgg gctgcaggtc gagggaccta gaattccgaa gttcctattc       60

tctagaaagt ataggaactt                                                   80


<210>  11
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the downstream of the Neo cassette and the 
       mouse sequence

<400>  11
gtataggaac ttcatcagtc aggtacataa tggtggatcc taagacatcc ccaaatccag       60

tctctccctc actttccctc                                                   80


<210>  12
<211>  3013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the engineered mouse CD38 after humanization

<400>  12
gcaggctctg acccagtcag ccctgtgctc tcttcctgcc tagcctgggc cagtcttcgg       60

gagcccaatg gctaactatg aatttagcca ggtgtctggg gacagacctg gctgccgcct      120

ctctaggaaa gcccagatcg gtctcggagt gggtctcctg gtcctgatcg ccttggtagt      180

agggatcgtg gtcatacttc tgaggccgcg ctcactcctg gtgtggactg gagagcctac      240

cacgaagcac ttttctgaca tcttcctggg acgctgcctc atctacactc agatcctccg      300

gccggagatg agacatgtag actgccaaag tgtatgggat gctttcaagg gtgcatttat      360

ttcaaaacat ccttgcaaca ttactgaaga agactatcag ccactaatga agttgggaac      420

tcagaccgta ccttgcaaca agattcttct ttggagcaga ataaaagatc tggcccatca      480

gttcacacag gtccagcggg acatgttcac cctggaggac acgctgctag gctaccttgc      540

tgatgacctc acatggtgtg gtgaattcaa cacttccaaa ataaactatc aatcttgccc      600

agactggaga aaggactgca gcaacaaccc tgtttcagta ttctggaaaa cggtttcccg      660

caggtttgca gaagctgcct gtgatgtggt ccatgtgatg ctcaatggat cccgcagtaa      720

aatctttgac aaaaacagca cttttgggag tgtggaagtc cataatttgc aaccagagaa      780

ggttcagaca ctagaggcct gggtgataca tggtggaaga gaagattcca gagacttatg      840

ccaggatccc accataaaag agctggaatc gattataagc aaaaggaata ttcaattttc      900

ctgcaagaat atctacagac ctgacaagtt tcttcagtgt gtgaaaaatc ctgaggattc      960

atcttgcaca tctgagatct gaaggatctg gatcttagat cacctgtagc ctggactgag     1020

atgaaggggc tcagaagcaa cactggtgga aagctgaaac tgtcagggag aagcctctac     1080

tacagtgtta acaccagaga tggaagaact tcccaattct ctgtgtacta ccaacattca     1140

agaaaaatta ctccataaac cagagttaaa cttctatatt gttatattag tctaactttc     1200

tcatgtggtg cttctgtatt gtttatatat tgcttacatc cttttattcc tcttttaatg     1260

atctctcttt tctctctctc tctctctctc tctctctctc aatgaggctg agaatccaac     1320

ctgagaactt tcatacatgg tggataagcc tatataccac tgagctaaat cctcagcaca     1380

gctgataaca tcatttttgc tgaaaaatgg ccaatcaaac ttcccattag acaaagaaag     1440

tcaaatgtca agtatatcga aatgaatgac cctttttttt ttttatgttt tttcattctt     1500

cccacagata ttcacatggt aaacctgagg tcatagggtc attataggga aggtgctgtg     1560

tgggaactac ccacgtgccc tgtgctttaa tctttaactc aacacatccc tgataacttt     1620

gagcattctt ttcttttctt ttctttcctt ttcttttctt ttcttttctt tttctttttt     1680

ttaaacagaa gaaaatggag tttagagaga taattgattt tcctaaagtc acattcttaa     1740

gatcatggtt acatctagaa ttaaatcagt tctgtcaaag tccacaacat atgatagttt     1800

ttttcttttc cgagctttta ttgccaaatt ggtagtagcc tgtgttgtcg tctagcaaat     1860

gctattgcat tagattgaat ataatagaat ctgaaatgtg atctttatgg aagatcacaa     1920

aactaattac ttgcaccctc tttctcttcc acttcattct tggtgccttt tataggcagt     1980

caagagttaa catatatttg ttgctaatat tggcaattta tgttttctat cctttttttc     2040

ttagatcagt cttgctcaga atcactggtt ttgttatgtt gttgttgttg ctattgttat     2100

tgttcttgtc tttttcaaag ctcaaatctt taactttcct catttattta tttaattgag     2160

ctttagtctt tatttttaga aacatagaaa tttcttctag ctatctggaa tatcttcagt     2220

tttttgaggc aaatgcttag accattgata tttcagtctg ttttctacac atgtacttta     2280

ggattctagg tttctccctg agccctgctt tcgatgtaac actgaatttc tgtatgtctt     2340

tactggttag ttactttgat agtttgtata tgcttgaccc agtgagtggc aggattagaa     2400

ggtatggcct tgctggaata ggtgtgccac tgtgggtgta gtcttaagac ccttacccta     2460

gctgcctgga ggccactatt ccactaacag ccttcaaatg aaaatataaa actctcagct     2520

ctgcctgtgc catgcctgcc tggatgctgc catgctccca ccttgatgat aatggactga     2580

acctctgaac ctgtaagcca gccccaattt gttgtcctta taaaagactt gctttggtca     2640

tggtatctgt tcacagcaga aagaacctaa ctaagacagt taccattcag ttcaaaataa     2700

ttcttgattt tattgttatt tagacatgtg atatttactt ttcaacatct ggagaattgt     2760

ttaggttttt tttgtgtgtg tgtctttagt aggtattaat aaactaaatt gagacaactc     2820

caaagtattt gcttggttta ttgaaaatag cataaacaga gccaggtgct tctgtattca     2880

tgttttgaca ccagtttgtg attgttgaac aatatatctt atttctaaac ttttaaaaag     2940

ctacttaaag acattaactt gctcccttac aatatgttga tggttcagtc cattaaatgc     3000

ttactttgta agt                                                        3013


<210>  13
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  encoded protein sequence of the engineered mouse CD38 after 
       humanization

<400>  13

Met Ala Asn Tyr Glu Phe Ser Gln Val Ser Gly Asp Arg Pro Gly Cys 
1               5                   10                  15      


Arg Leu Ser Arg Lys Ala Gln Ile Gly Leu Gly Val Gly Leu Leu Val 
            20                  25                  30          


Leu Ile Ala Leu Val Val Gly Ile Val Val Ile Leu Leu Arg Pro Arg 
        35                  40                  45              


Ser Leu Leu Val Trp Thr Gly Glu Pro Thr Thr Lys His Phe Ser Asp 
    50                  55                  60                  


Ile Phe Leu Gly Arg Cys Leu Ile Tyr Thr Gln Ile Leu Arg Pro Glu 
65                  70                  75                  80  


Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 
                85                  90                  95      


Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 
            100                 105                 110         


Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 
        115                 120                 125             


Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 
    130                 135                 140                 


Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 
145                 150                 155                 160 


Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser 
                165                 170                 175     


Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 
            180                 185                 190         


Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val 
        195                 200                 205             


His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser 
    210                 215                 220                 


Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 
225                 230                 235                 240 


Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 
                245                 250                 255     


Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 
            260                 265                 270         


Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 
        275                 280                 285             


Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300                 


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
attctctgca aattaccaac tcttcca                                           27


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
gttacatcga aagcagggct cagg                                              24


<210>  16
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
atcagtcttg ctcagaatca ctggtt                                            26


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ggttgttggg acagttttca ctcca                                             25


<210>  18
<211>  1370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  18
taagagaagc atagaaataa tttgtgaagg acgtgagttt cagcacttaa ataagagttt       60

gctgatgaga aggtctgctg tgtggcaggg tctcagggca ggataactgc tctttcccac      120

cacgcttcca gaagtggaaa atgttctctc cttcttccat cttcttctgt ttcaagtcct      180

gcagatgctc caaaggaaag acgtagagat ttttatgacg gttgggactt agaacagaga      240

gttcttgaga aggccactgc attaattacc agaaagaaaa cataaaccct ggaagccggg      300

aagccgccaa acgtctattt tctcaattgc ctgtgatggt actctataaa ttttgattga      360

cactaaagta catgatgtca tcacttttcc tttttatgta tgtaaacggt acggaaggag      420

agggccctaa tggtttcctg gcatcgtttt caaaggcagg tgctgatgaa cttaagcttc      480

tcagtctaga ctctggaaag aaaccccatc aaacctttca cattttcatt tgtatcccct      540

gattctcaac ccgaactagg gtcagaactg cctggggtgg gggtgggggt ggggtggaag      600

tgggaggtat gaatgccact gatgatcccg cccaacatta ccaagcccac ctgcagtaac      660

cctacctact taaagtttta gtctgacaca gagtaattgg acatatttat gagtacaatg      720

tggcatttgg cctatgtata cactgtataa agaacagtga cagacagctc tatcgcctca      780

ggtgctcatg acttctctgt gttgggaaca ttcggtcctc tctacttgct gttttgaaac      840

attgccctta ctgggggtac taaagaacct taaggacttt ttttatacaa ggtgtagtat      900

gagacagaaa acgctggtgt cttcctattt tcttcttaat gttattagat gcttgggtca      960

ttttaatttc acagagcctc agcctcaggt aattttcatc tcacagggac attttacaca     1020

gctaatagga tggtgtcaag aactgactgc ccctgggtat atgattccag atgaagggta     1080

tttcttgttg ctatctatgt tccaaaaata ttttttaaac tttttcaatg tctttctttt     1140

tttcttttat ttattttttt tatatgttcc taagattgat atttatttta catgtagagt     1200

tgttttgtct gtagatatgt tcatgcacca tgtatgtgca gtgactgtgg aagccagatg     1260

gaggtgttag ctctggaaac tgaacacact gttgggagcc accgtgagcc atctctccag     1320

actcttcaaa aatattttta aaatctgttt tccatctttc attttataga                1370


<210>  19
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  19
taagacatcc ccaaatccag tctctccctc actttccctc tctacatcct tcctgttctc       60

cccttttcct gcctcttcca ctttcctctt ttccctcctc cctctccact ttcttctttc      120

tcttctgcac ttttggcaag aaatctcctc cttaaccttt atatatgtat ttacacacac      180

acacacacac acacacacac acacacacgt tatatattct tgaacataac tctaagtcat      240

ttttttaaaa aaatttaaat taaaattata tatattttta tctgtacaga gtaatattgg      300

atataaatag acatagtgaa cggattgtta tctgtgagct atttaacatg gacaactttg      360

ggtaccatct taaggtgatc tctttctttc cccttcatag ccagtgatga tctatttgcc      420

tagagagcca tctgtgcatc tcccctcaca ctgcctttta gcaccatcac accctctcca      480

tcctgctggg aatgctataa ggttttactg gtcactcttt accctcctag gtcagtctcc      540

atctgacacc atagtttttc tcagagtgaa aatgggatga tgtcgatctc cctctagaac      600

ctaacaatct ctcttttgac tctaggctaa tggtctaaag acctgacctc tgtgtttcag      660

atgcctcacc ttctcattcc cttctccatc ctcttttctg atcaaagctc atcatggctc      720

tttgcctttg caccgtgcca taggcacaag gtgcccttct ctttagagtc tgtctgaaga      780

cagtgattct tcttcaaagt aaatttcaac gtgaatctgt ctctgattat ttgacttcac      840

tacatcacat gtcctatgag gcagggctcc cacctgattc aaccctctat ctccagaacc      900

taaccttcag taaatgttta tatatatatg tgtgtgtgtg tgtgtgtgtg tttatatata      960

tatgtatata tatatgtata tatatatata tatgcaaata accttgagaa cagtgtcata     1020

gaaaccatgc ttctactcta tactttgcac cacactaagg gctaaacctg ttttggtagg     1080

gttgactata gaaagcctga gatcacctga gcccccaaat ttatggaggt tgaaaaggaa     1140

actctccata aaagagaatt gccaggaatc agaggactat ctgggggaaa gtgtcttctt     1200

cccgaaaagg cctggccttc tccctaagtg ttcctggact ccaggggagt gagaggggcc     1260

ggtgtcttta gggtgcactt ttgttgccat ttcccagaat ggtgagtcaa aacccatcac     1320

agtgttcctg tctgggatct ggacggggag gtaaagagtt ggaaggaaat caggggacac     1380

ttacttaaat tgggt                                                      1395


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  20
tgagtgacca atttaacaag tgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  21
tgaatgtact cagtatctcc tgg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  22
tgtgatgttg caagggttct tgg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  23
gccctcatta ccttgttaca tgg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  24
gagtgaccaa tttaacaagt ggg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  25
tcaaaccata ccatgtaaca agg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  26
gagatactga gtacattcaa agg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  27
tcttctcttg tgatgttgca agg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  28
agggaattta cccccatgaa tgg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  29
atgagctcaa ctccatttag agg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  30
gctactttat aaggctgttg agg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  31
taaatggagt tgagctcatg agg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  32
ctagattagt gatcacaaaa agg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  33
attcagctta atgggaacat tgg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting site

<400>  34
ggattaaaaa tccattcatg ggg                                               23


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 upstream sequence

<400>  35
tgaatgtact cagtatctcc                                                   20


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 forward oligonucleotide

<400>  36
taggtgaatg tactcagtat ctcc                                              24


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 downstream sequence

<400>  37
ggagatactg agtacattca                                                   20


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 reverse oligonucleotide

<400>  38
aaacggagat actgagtaca ttca                                              24


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA11 upstream sequence

<400>  39
gctactttat aaggctgttg                                                   20


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA11 forward oligonucleotide

<400>  40
taggctactt tataaggctg ttg                                               23


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA11 downstream sequence

<400>  41
caacagcctt ataaagtag                                                    19


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA11 reverse oligonucleotide

<400>  42
aaaccaacag ccttataaag tag                                               23


<210>  43
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA fragment containing the T7 promoter and sgRNA scaffold

<400>  43
gaattctaat acgactcact atagggggtc ttcgagaaga cctgttttag agctagaaat       60

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      120

tttaaaggat cc                                                          132


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
ctaggcactt agcaggatgc ccttg                                             25


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
cctgaagccc aaggatgtga aagga                                             25


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46
aactgatgaa tgggagcagt ggt                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
gcagacactc tatgcctgtg tgg                                               23


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
accatgtatg tgcagtgact gtgga                                             25


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
cacagataac aatccgttca ctat                                              24


<210>  50
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the downstream of the mouse 3'UTR and the 
       upstream of the LoxP STOP sequence

<400>  50
gatggttcag tccattaaat gcttactttg taagtgtcga cattaagggt tccggatcct       60

cggggacacc aaatat                                                       76


<210>  51
<211>  1594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of the humanized mouse CD38 gene (chimeric CD38 gene
       DNA)

<400>  51
gtcccgaggt ggcgccagca gtggagcggt ccgggcacca ccaagcgctt tcccgagacc       60

gtcctggcgc gatgcgtcaa gtacactgaa attcatcctg agatgagaca tgtagactgc      120

caaagtgtat gggatgcttt caagggtgca tttatttcaa aacatccttg caacattact      180

gaagaagact atcagccact aatgaagttg ggaactcaga ccgtaccttg caacaagatt      240

cttctttgga gcagaataaa agatctggcc catcagttca cacaggtcca gcgggacatg      300

ttcaccctgg aggacacgct gctaggctac cttgctgatg acctcacatg gtgtggtgaa      360

ttcaacactt ccaaaataaa ctatcaatct tgcccagact ggagaaagga ctgcagcaac      420

aaccctgttt cagtattctg gaaaacggtt tcccgcaggt ttgcagaagc tgcctgtgat      480

gtggtccatg tgatgctcaa tggatcccgc agtaaaatct ttgacaaaaa cagcactttt      540

gggagtgtgg aagtccataa tttgcaacca gagaaggttc agacactaga ggcctgggtg      600

atacatggtg gaagagaaga ttccagagac ttatgccagg atcccaccat aaaagagctg      660

gaatcgatta taagcaaaag gaatattcaa ttttcctgca agaatatcta cagacctgac      720

aagtttcttc agtgtgtgaa aaatcctgag gattcatctt gcacatctga gatctgaaat      780

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct      840

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg      900

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg      960

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     1020

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     1080

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     1140

ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc     1200

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     1260

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     1320

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg ataccgtcga     1380

cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     1440

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     1500

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     1560

aggattggga agacaatagc aggcatgctg ggga                                 1594


<210>  52
<211>  4730
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  52
ctgctgtgac ggttaatatc gactctggaa tcatctagga gacatgtcat tggcatgttt       60

tcggaagatt tttctagatt gagctagttg aagtagaaag actaatcata agtaaggata      120

atatggataa atatcccaac cattctatca tttgggaacc ctagtctaaa taaaaagaat      180

gtgaactgaa cgatagtttt cattgctcta agcttcctga ccaaagacca gctctctcat      240

gctccctcca tatcgcctct gccacggtgg acaagactaa tgttgagttt gacctgtgaa      300

gtcacggaag gataaatgtc ctgggctctt ataatcctgc agtcccatta gaatcatggc      360

agcaataact tgtgtctttt cactgttttt tatctttctt ttgtgctgga ggatttagga      420

gccatggtct attatttaaa tctatccttg ctcaaatttc agtttggtgt ttacccagtg      480

ttaaggataa caggacttca tgacaactcc cataattctt aggtctaagc cctaaacttc      540

atgtctcaaa aggcagctgt attagaagat agcccagtta cctgtataga ataattaaac      600

tgagaccatg gagggaggga aggctcaaat ccatcacctg gtggtttcat acaaactgga      660

aattagatcg cagactgtta cagacatacc tgctcagcga ataaagacga agagaagggc      720

agactgaaag ccgagtggac aggcctcaga acgagccacc catgcagaaa ccttgatcct      780

gaacatccag tagtgcaaga caatacattt cttttgctta agacacccag tgtgtgtgat      840

actgtgctat ggcatctcca acagactggc tgactgagct tagacctttg tccattttct      900

tttgttgttg ttgttttgtt ttgttttttg tttttgtcta ggcagtgggt gtggttgcac      960

aaacgggggt ggggttgggg gtggggcggg agggggcggg gttcactaac tggcctttct     1020

ttgaactttt aaccatttaa tgacaccctg aagacttgtc tactccccag cctgactagt     1080

agtctccatc agtgttccaa acagttcctc acaggagtgt tctctttcta cttcatgaaa     1140

gaagcaatca ggagacaact tccttgtcaa aacccccacc cttgcatatt ctccacctct     1200

ttttgtaagg agctggagct tcagcccaca tccccaccgt gcctcagctt cctctcccca     1260

tctcctgcat ttgtcaagtg ttactgtgtg agtcatcttg tcagcctcca aaagtcctgt     1320

gagaagtctg gtctcagaac aggatgctgt ttcctgactc ccaggctatt gttactttct     1380

cattgttgag gaaaaaatat ccaacgtgac aactgaaaag aaggaaattt cactttggtt     1440

caggttttag aggatttggt ccatggtctc ttggcttcat ggtttttttg tttgtttgtt     1500

tgttttggtt ttttttggtt tttgtttttg gtttttcaag acagggtttc tctgtgtagc     1560

cctgactgtc ctagaactca ctttgtagac caggctggcc tcgaactcag aaatccgcct     1620

gcctctgcct cccgagtgct gggattaaag gcatgcgcca ccacgcccgg caacttcatg     1680

cttttggtag agcattatat ggcatagagg aatagttcac atcatgacca accagaaggc     1740

agagaactgg acaggaagtt gtcagggata gcacagtaca gcatcaaaga cttttaacga     1800

gtaacccaag tcctccatct tggcccatcc tcctaaattc ataaaccttc taaaatagtt     1860

ccccaacctg aggtccaaga gttctaaaat catgatccta tagagaattt tacatatcca     1920

catcataatg cccagcatct tccaattgca tccttatttc tctgttcctt ttgacactaa     1980

gcaagcaaac aaacaaacaa acaaaatggc tccctttttc aacacaactg caccctaact     2040

tactaagaga accttcaaac cttctcttga acctacctgc tggactgtgt ccttctcatt     2100

ccctgaaaat ctgaaaatgt tccctctcga ggacggaaag aagcatttaa gactttgctg     2160

ttcttgcaga aaactggact taggccctag catccgcatc aggcagctta cagccattta     2220

cgacttcaat tctgagggac ctgatgccct actttggccc atatggccat cccacataag     2280

agcctacaca tacatgcaca aataatatgt tgttttttaa aattaattaa ttaatttttt     2340

gttagttaag aacttctttc tttttcatga gtcacccttc caagtttcct ttgctgggat     2400

tttcacactt ttctgactct tacgtcaaga atgttcccca aggttttaaa acttctccat     2460

tccatctgtt acatagtctt tctgtgacat gacgaccctc tttacaaact gtgctgaaac     2520

ttcatgtgcc aggtcattta aggtcactga tcttaaacag gttaaaacag aattctgtgc     2580

tgataaaatg gcctgacctg ttcagtcttc tctgctgtca gacctgatga ccccagttta     2640

atgccttgga cacacatggc agagagagag aaaggacccc tcaaaggtgt ccttggtcct     2700

ccattcatgt cctgtggcat atattcacac acacacacac acacacacac acacacacac     2760

acacacacac agagagagag agagagagag agagagagag agagagagag agagagagag     2820

aaccaaagaa ctgcaggaac aaaaatgaag gtccagttaa caggcccagc tcaaggggag     2880

gctccaaggc ctgacattat tactgatgct atggagtgct tacaaacaag ggcctaacat     2940

gactgccttt cgaaaggccc aacaagcagc tgaatgagtc cgatgcagat atttacaccc     3000

aatcaatgca cagaagctgg tgacccctgt ggttaaatta gggaaaagct agaagaagct     3060

gaggaggagg gcaaccctat aagaacagca gtctcaacta acctggacct tcgagaccac     3120

tcagacactg agccaccaac caggcagcac acaccagctg atatgaggtc cctaacacat     3180

atacagcaga agagtgctgg gtctggactc agtcagagaa gatgcaccta accctctaga     3240

tacttggggc cccagggagt gaggaagtct ggtggggtgg ggggtaggga taggggtggg     3300

gacatcctct tggagagggg gtggggagga ggaggtgagg gaatgtacca ggagggagat     3360

gaagtctgga ctgtaaaaaa agattaaaga atgtattttt aaaaaagaaa aagaaaacac     3420

aggaaaaaaa agaaagagag ggagagaggc acacaaaatg aataagcaaa atgacagcaa     3480

acgtttaaaa aaaaatgaaa tgcacagtct aaaaaagtcc tcctgacata cggagctgca     3540

gagacttact ctcctgctgc cttcggaagg attctctgtc atcctgtagt atagctgcaa     3600

tgctgctttc ccgcatctta aaacagaaca aggggctttc ctgccccagc tcttgcatcc     3660

agtaccctct gcctgaaaag tgtcccgtga aaatcctgtg tcatgatcca ttctgtgaca     3720

agtctctgtt taagcagaag agtgcggggt cttcttggga aggagagcca ggaagagcct     3780

ttgtatttgg ggttcccatg tgggatgaag tattactgca catgagatgg gttgcgagca     3840

tcctatcaac tctaaaatcc tacctttgtc aaccccctag agtaagcagc aataacttac     3900

atttattgag taatcggttg ttatgtctta gggattatgc taaacaccta ggaggtatta     3960

agccatctaa tcaaagcaag ctttgatgta atgaatgtga ggctctgctc acatctatct     4020

agttcagaga ggtaagttta tcttaacagc actttaccat ctggggctgg gtttgaactg     4080

atacctcctg agaagagggg cagagtaaag ctgagacttt aaagatactt gggcaggatt     4140

tttatcaaag ctcagaagta gaggtaagca ggccattcat tgccaggcat ttgggtgaac     4200

agagagagag agggagggag gagagggaga gggagaataa ttttacacac acacatacac     4260

acacacctga gcataagtag caaacatgtc aagtgtcaag gttgttggtc aggagtattc     4320

tgaagctgtt gtttgtgtac cagcagaggc taaagtgctg tcttctcttg gagagagagg     4380

ttctggtcag tttgctctgg agtctggaag taagcagttg gagtgcctgt tgacaaccca     4440

agagccttat tagtccagtc acctccgtgg aactttggag caggagtagg gggtgggaaa     4500

ggaagcagat aaaagcaagt gaaaaaaagg aggaggggca ggctctgacc cagtcagccc     4560

tgtgctctct tcctgcctag cctgggccag tcttcgggag cccaatggct aactatgaat     4620

ttagccaggt gtctggggac agacctggct gccgcctctc taggaaagcc cagatcggtc     4680

tcggagtggg tctcctggtc ctgatcgcct tggtagtagg gatcgtggtc                4730


<210>  53
<211>  3783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  53
aggtgagttg gcttctgagg ctcactctag gcacagtgcg cagcgggaca ccggggaagc       60

aggctgtgac tcagctggag ctctcgcggc gggggggaat cttccagatt gtcccaaaca      120

aagaatcttg tgttgtggat cagctggaag ccgaagggca gtgctgagcg gaaggtctcc      180

tgttcaagtt accagaacac cgcctgcaca atgcctcctc cgttttggca gtgtctgtga      240

tgggggcgcc gatccttgct gagctctgca aagatgctcg cttcccacag agggtcctga      300

actctgaagg aacccttagg gctatctttg gccacagcca tgcttctggg acaaagatta      360

ctctcaggca caggaacttc acattgtctt ttggcttgtg gtttccatca gacaccgccc      420

ctgcccagaa agttaaggtc acaggcgaca tttaactagg tggcttgctc agcttgctgt      480

gggggtggaa ggggccagga ggatttttgt gaattcaagg ttaacaaggg ctgcacagca      540

acattgtaaa ttccaggaca agcttgggtt acaaagagag acctgactca aaataagtta      600

attaatttta attaattaca acacaaagaa aacaaaaaac aagcccaaac agcatcctgg      660

tctttttttt tttttgcacc tgatcattaa taaaaacaaa acaagacaga ctgtcaaaac      720

tgaaatatta ctcatcaggt aagcgaaatc cacttggtga tcctgtgtag acccttggga      780

acatcatctt cattggtcaa tagagtcagc ccatagaacc ccttccaccc actacctgcc      840

ccagagggaa tgatttatgt tgcttctccc tggcatcatt ttaacgtaga actgatttct      900

gaagtcaaac agaaagccca gcaggctggg aaggcacacg cagaaaccca acttcacatt      960

ctgtcttcag atgcacacac ttcccgggtg ctcgaatgct cagtggtttg ggtcctggtc     1020

ttacttgaaa atgttggagt ataaacactc tcagggtcct gataaatatt ttgtttacag     1080

atgtttaaat gatattggtt gttcagccat tttgatagct tgtaaatttt ctgtgcttag     1140

caaaccagat gcatggcact ggcatgatgt gtgcttagca ttaaccatgt ggtgtagacg     1200

gtaagcactt cttcaaccta tccactcatg tgtatatgtg tgcattcagc aagaattaat     1260

tatttgtgtt tatcaaataa taatcaatct aaaaataaca ggattaacta ataaaagtat     1320

atatatttac tctgtgtgtg tacatgtgtg tgtgtgtgtg cacacacgct cgtaagtgcg     1380

tgagtgcctg ttccacagta cacgtgcaga aatcatggaa ttcagttctt tgcttccact     1440

ctgtagcttc tgggaatcaa attcagataa ttagaggttt ggaagcaagc atccctacct     1500

gctagtctgt atcatttgcc taacatatta ctattgtgat gagcatcttt tcagacatct     1560

cacacacaca cacacacaca cacacacaca cacacacaca cacacacact ttatatgaat     1620

agattagtgg caggtacatc tcatgtgtca ggcacttatg tcaggagctg aggtgcagct     1680

cagtgataga gctctggcct ggtttacaaa gtgccctggg ttcaccctca gcatcgcagt     1740

agaggaatga gtggaacaga atcaaccagg acagaaggca acgatacata gacggttgct     1800

attgatatct ccattttata gataagaaaa gggagtcaaa agctgaaccc tgttgagccc     1860

tgaagccaga tcattggagc tggaatcttg gctctgttgc gacctcagac cccgccctca     1920

gtgtatctgc gctgtggtgt gttcccacct tgtaaaatgg gaacgttaat ggcagcactc     1980

ggcatctaga gtaaacgaag aggactaaga tgaataatct tgtcatggta aatgctcaaa     2040

atgttactgc tgtgtaaatg gagtgttgca gatacctctc cacaatagca aatataaaat     2100

aagtacaggc gttcatgcat tagaacattg ttgtataatt cagtcctcca gtgctgaaag     2160

ttacatcgtt tcgaatcttg ttcacctaac acttggtggt gatagggtct ctcatattgc     2220

tacacccaaa tctaccttat tttttatagc gtagatgtaa ccatttccag tcatcaaaaa     2280

tttaatttcc aattttaaat tacatatctc tgttacattt aggggatggg aggattgcca     2340

tagggcatgc atggaagttg gttctttctt cccctatgta ggttctggga atcaaactca     2400

ggtctttagg cttggcagca atcaccttta tttaaatgag acatcgtgct ggcccatttt     2460

ctaatttttc aatcccattc attcattcat tagatatttt tgagcctctg ctgggttcca     2520

ggtgggtgat ctggctactg gtggcacagg aggggtagtg tcctgattct tgtccagctt     2580

tcccttacag taaacatctt caacttatac cttcatgtgt gcactggagc gttctgtatg     2640

acagactccc actgatagaa tgagattgta catgttttag ttagggtttc tattgctatg     2700

aagagatacc acgagcacag catatcttgt aaatgaaaat atttaattgg ggctgactta     2760

cagttcagaa gttttagttc attatcatga tgatggcata caggcagaca tagtgatgga     2820

gaaggagctg agagttctac atctggactg acatacaaca ggaagacaga cagacacttg     2880

gcctgccttg agcatctaaa aaccacaaag cccactcaca cacttcctcc aataaggcca     2940

cgcctactcc aacaagacca cacctcctaa tagtaccact ctctatggac ctttgggggc     3000

cattttcact caggtcacca cagtgcatat tttgtttgag tggctttcaa attgcacatg     3060

tttctaaatc ctctgtgaaa tagttttatt agttatttat taactctcat atcagtctac     3120

agggcccact tctccatgat atgaccatta ttaaatgtct taaatctttt taaattatga     3180

gaaagatgga aagataacat ataaccattc cctgtttgcc agcaagtctt ctgtctggct     3240

tttgtccatt taaactttgt tcagatcttc actctttctg ttgagttaat tacatatgtg     3300

attttgggtt gttcatattc tagataatat ttatacacac agacacaaag tatctcacag     3360

ctacatcact aaggcctcca ccccaaggac acattttact gacaacaccc tgagtttcat     3420

tattatattg gggctacttc ttattttgat acccttacta agaagcaccg agaaagccag     3480

ttttattttc aaacctagtg cactggaaat gtttactctc tgttctgcac tatgaatcag     3540

gaattctttc ctctctgggt ctgcactttc tcttgcacag ctagaaagca aagaagcgac     3600

cctcagcttc tgcactaaga gtttgagcca cagctttggg ttcctagggg gagttatgca     3660

tcttcccttt ggcagttgac aagagttaca tcttacatca cttctgcaag gggctgtgtt     3720

tcttccagcc tccaatgacc acttcctgtg tgtccatcag gttagcatga acagtccctc     3780

ctt                                                                   3783


<210>  54
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the nucleotide sequence 214-990 of NCBI accession number 
       NM_001775.4

<400>  54
gtcccgaggt ggcgccagca gtggagcggt ccgggcacca ccaagcgctt tcccgagacc       60

gtcctggcgc gatgcgtcaa gtacactgaa attcatcctg agatgagaca tgtagactgc      120

caaagtgtat gggatgcttt caagggtgca tttatttcaa aacatccttg caacattact      180

gaagaagact atcagccact aatgaagttg ggaactcaga ccgtaccttg caacaagatt      240

cttctttgga gcagaataaa agatctggcc catcagttca cacaggtcca gcgggacatg      300

ttcaccctgg aggacacgct gctaggctac cttgctgatg acctcacatg gtgtggtgaa      360

ttcaacactt ccaaaataaa ctatcaatct tgcccagact ggagaaagga ctgcagcaac      420

aaccctgttt cagtattctg gaaaacggtt tcccgcaggt ttgcagaagc tgcctgtgat      480

gtggtccatg tgatgctcaa tggatcccgc agtaaaatct ttgacaaaaa cagcactttt      540

gggagtgtgg aagtccataa tttgcaacca gagaaggttc agacactaga ggcctgggtg      600

atacatggtg gaagagaaga ttccagagac ttatgccagg atcccaccat aaaagagctg      660

gaatcgatta taagcaaaag gaatattcaa ttttcctgca agaatatcta cagacctgac      720

aagtttcttc agtgtgtgaa aaatcctgag gattcatctt gcacatctga gatctga         777


<210>  55
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   connection between the upstream of the human CD38 gene sequence 
       and the mouse CD38 gene locus

<400>  55
ctcctggtcc tgatcgcctt ggtagtaggg atcgtggtcg tcccgaggtg gcgccagcag       60

tggagcggtc cgggcaccac                                                   80


<210>  56
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the downstream of the Neo cassette and the 
       mouse CD38 gene locus

<400>  56
gaacttcatc agtcaggtac ataatggtgg atccccatgg aggtgagttg gcttctgagg       60

ctcactctag gcacagtgcg                                                   80


<210>  57
<211>  1787
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the engineered mouse CD38 after humanization

<400>  57
gcaggctctg acccagtcag ccctgtgctc tcttcctgcc tagcctgggc cagtcttcgg       60

gagcccaatg gctaactatg aatttagcca ggtgtctggg gacagacctg gctgccgcct      120

ctctaggaaa gcccagatcg gtctcggagt gggtctcctg gtcctgatcg ccttggtagt      180

agggatcgtg gtcgtcccga ggtggcgcca gcagtggagc ggtccgggca ccaccaagcg      240

ctttcccgag accgtcctgg cgcgatgcgt caagtacact gaaattcatc ctgagatgag      300

acatgtagac tgccaaagtg tatgggatgc tttcaagggt gcatttattt caaaacatcc      360

ttgcaacatt actgaagaag actatcagcc actaatgaag ttgggaactc agaccgtacc      420

ttgcaacaag attcttcttt ggagcagaat aaaagatctg gcccatcagt tcacacaggt      480

ccagcgggac atgttcaccc tggaggacac gctgctaggc taccttgctg atgacctcac      540

atggtgtggt gaattcaaca cttccaaaat aaactatcaa tcttgcccag actggagaaa      600

ggactgcagc aacaaccctg tttcagtatt ctggaaaacg gtttcccgca ggtttgcaga      660

agctgcctgt gatgtggtcc atgtgatgct caatggatcc cgcagtaaaa tctttgacaa      720

aaacagcact tttgggagtg tggaagtcca taatttgcaa ccagagaagg ttcagacact      780

agaggcctgg gtgatacatg gtggaagaga agattccaga gacttatgcc aggatcccac      840

cataaaagag ctggaatcga ttataagcaa aaggaatatt caattttcct gcaagaatat      900

ctacagacct gacaagtttc ttcagtgtgt gaaaaatcct gaggattcat cttgcacatc      960

tgagatctga aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     1020

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     1080

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     1140

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     1200

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     1260

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     1320

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     1380

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     1440

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     1500

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     1560

tcgataccgt cgacctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     1620

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     1680

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     1740

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctgggga                   1787


<210>  58
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  encoded protein sequence of the engineered mouse CD38 after 
       humanization

<400>  58

Met Ala Asn Tyr Glu Phe Ser Gln Val Ser Gly Asp Arg Pro Gly Cys 
1               5                   10                  15      


Arg Leu Ser Arg Lys Ala Gln Ile Gly Leu Gly Val Gly Leu Leu Val 
            20                  25                  30          


Leu Ile Ala Leu Val Val Gly Ile Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  59
<211>  303
<212>  PRT
<213>  Rattus norvegicus

<400>  59

Met Ala Asn Tyr Glu Phe Ser Gln Val Ser Glu Asp Arg Pro Gly Cys 
1               5                   10                  15      


Arg Leu Thr Arg Lys Ala Gln Ile Gly Leu Gly Val Gly Leu Leu Leu 
            20                  25                  30          


Leu Val Ala Leu Val Val Val Val Val Ile Val Leu Trp Pro Arg Ser 
        35                  40                  45              


Pro Leu Val Trp Lys Gly Lys Pro Thr Thr Lys His Phe Ala Asp Ile 
    50                  55                  60                  


Ile Leu Gly Arg Cys Leu Ile Tyr Thr Gln Ile Leu Arg Pro Glu Met 
65                  70                  75                  80  


Arg Asp Gln Asp Cys Lys Lys Ile Leu Ser Thr Phe Lys Arg Gly Phe 
                85                  90                  95      


Ile Ser Lys Asn Pro Cys Asn Ile Thr Asn Glu Asp Tyr Ala Pro Leu 
            100                 105                 110         


Val Lys Leu Val Thr Gln Thr Ile Pro Cys Asn Lys Thr Leu Phe Trp 
        115                 120                 125             


Ser Lys Ser Lys His Leu Ala His Gln Tyr Thr Trp Ile Gln Gly Lys 
    130                 135                 140                 


Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Ile Ala Asp Asp Leu 
145                 150                 155                 160 


Arg Trp Cys Gly Asp Pro Ser Thr Ser Asp Met Asn Tyr Asp Ser Cys 
                165                 170                 175     


Pro His Trp Ser Glu Asn Cys Pro Asn Asn Pro Val Ala Val Phe Trp 
            180                 185                 190         


Asn Val Ile Ser Gln Lys Phe Ala Glu Asp Ala Cys Gly Val Val Gln 
        195                 200                 205             


Val Met Leu Asn Gly Ser Leu Ser Glu Pro Phe Tyr Arg Asn Ser Thr 
    210                 215                 220                 


Phe Gly Ser Val Glu Val Phe Asn Leu Asp Pro Asn Lys Val His Lys 
225                 230                 235                 240 


Leu Gln Ala Trp Val Met His Asp Ile Lys Gly Thr Ser Ser Asn Ala 
                245                 250                 255     


Cys Ser Ser Pro Ser Ile Asn Glu Leu Lys Ser Ile Val Asn Lys Arg 
            260                 265                 270         


Asn Met Ile Phe Ala Cys Gln Asp Asn Tyr Arg Pro Val Arg Phe Leu 
        275                 280                 285             


Gln Cys Val Lys Asn Pro Glu His Pro Ser Cys Arg Leu Asn Val 
    290                 295                 300             


