                         SEQUENCE LISTING

<110>  Universitt Heidelberg
       Panda-Jonas, Songhomitra
 
<120>  AGENTS FOR USE IN THE THERAPEUTIC OR PROPHYLACTIC TREATMENT OF 
       RETINAL PIGMENT EPITHELIUM ASSOCIATED DISEASES

<130>  3834/P/1002-WO

<150>  EP 20 167 033.8
<151>  2020-03-31

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(8)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(13)
<223>  Xaa may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa may be any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(25)
<223>  Xaa may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(28)
<223>  Xaa may be any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(36)
<223>  Xaa may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa may be any amino acid

<400>  1

Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Cys Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Gly Xaa Arg Cys 
        35                  40  


<210>  2
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  2

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  3
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  3

Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met 
1               5                   10                  15      


Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr 
            20                  25                  30          


Ile Gly Glu Arg Cys 
        35          


<210>  4
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln Asn Lys Thr Glu 
1               5                   10                  15      


Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys Lys Gly Gly Lys 
            20                  25                  30          


Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn Pro Cys Asn Ala 
        35                  40                  45              


Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys Tyr Ile Glu His 
    50                  55                  60                  


Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr Phe Gly Glu Arg 
65                  70                  75                  80  


Cys Gly Glu Lys Ser Met Lys 
                85          


<210>  5
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys Tyr 
1               5                   10                  15      


Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr Phe 
            20                  25                  30          


Gly Glu Arg Cys 
        35      


<210>  6
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys 
1               5                   10                  15      


Pro Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys 
            20                  25                  30          


Lys Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys 
        35                  40                  45              


Tyr Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu 
    50                  55                  60                  


Arg Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys 
65                  70                  75                  80  


His Gly Leu Ser Leu 
                85  


<210>  7
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Leu Arg Lys Tyr Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr 
1               5                   10                  15      


Val Lys Glu Leu Arg Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His 
            20                  25                  30          


Gly Glu Arg Cys 
        35      


<210>  8
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


<210>  9
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Pro Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe 
1               5                   10                  15      


Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val 
            20                  25                  30          


Gly Ala Arg Cys 
        35      


<210>  10
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ala Val Thr Val Thr Pro Pro Ile Thr Ala Gln Gln Gly Asn Trp 
1               5                   10                  15      


Thr Val Asn Lys Thr Glu Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu 
            20                  25                  30          


Lys Phe Ser His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn 
        35                  40                  45              


Gly Ala Cys Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys 
    50                  55                  60                  


Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu His Leu Thr Leu Thr Ser 
65                  70                  75                  80  


Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile Ala Ile Gly Ile Gly Val 
                85                  90                  95      


Gly Leu Leu Leu Ser Gly Phe Leu Val Ile Phe Tyr Cys Tyr Ile Arg 
            100                 105                 110         


Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu 
        115                 120                 125             


Arg Arg Pro Leu 
    130         


<210>  11
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe 
1               5                   10                  15      


His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr 
            20                  25                  30          


Gly Glu Arg Cys 
        35      


<210>  12
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly 
1               5                   10                  15      


Asp Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys 
            20                  25                  30          


Gly His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys 
        35                  40                  45              


Gly Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys 
    50                  55                  60                  


Asp Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr 
65                  70                  75                  80  


<210>  13
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly Arg Cys Arg Phe 
1               5                   10                  15      


Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp Glu Gly Tyr Ile 
            20                  25                  30          


Gly Ala Arg Cys 
        35      


<210>  14
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro Ala Leu 
1               5                   10                  15      


Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser 
            20                  25                  30          


Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg 
        35                  40                  45              


Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro 
    50                  55                  60                  


Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile 
65                  70                  75                  80  


Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile 
                85                  90                  95      


Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu 
            100                 105                 110         


Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr 
        115                 120                 125             


Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala 
    130                 135                 140                 


Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu 
145                 150                 155                 160 


Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu 
                165                 170                 175     


Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys 
            180                 185                 190         


Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val Pro Met 
        195                 200                 205             


Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln Lys 
    210                 215                 220         


<210>  15
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe 
1               5                   10                  15      


Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln 
            20                  25                  30          


Pro Gly Phe Thr Gly Ala Arg Cys 
        35                  40  


<210>  16
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala 
1               5                   10                  15      


Pro Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly 
            20                  25                  30          


Ser Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala 
        35                  40                  45              


Leu Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln 
    50                  55                  60                  


Arg Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn 
65                  70                  75                  80  


Gln Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe 
                85                  90                  95      


Lys Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys 
            100                 105                 110         


Glu Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu 
        115                 120                 125             


Lys Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu 
    130                 135                 140                 


Lys Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe 
145                 150                 155                 160 


Lys Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr 
                165                 170                 175     


Gly Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val 
            180                 185                 190         


Glu Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys 
        195                 200                 205             


Asp Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu 
    210                 215                 220                 


Ser Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser 
225                 230                 235                 240 


Tyr Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln 
                245                 250                 255     


Leu Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu 
            260                 265                 270         


Lys Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys Ala Glu 
        275                 280                 285             


Glu Leu Tyr Gln Lys 
    290             


<210>  17
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Asn Glu Thr Ala Lys Ser Tyr Cys Val Asn Gly Gly Val Cys Tyr 
1               5                   10                  15      


Tyr Ile Glu Gly Ile Asn Gln Leu Ser Cys Lys Cys Pro Asn Gly Phe 
            20                  25                  30          


Phe Gly Gln Arg Cys 
        35          


<210>  18
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Glu Gly Ala Ala Ala Ala Ser Pro Pro Gly Ala Ala Ser Ala 
1               5                   10                  15      


Ala Ala Ala Ser Ala Glu Glu Gly Thr Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Gly Gly Gly Pro Asp Gly Gly Gly Glu Gly Ala Ala Glu Pro 
        35                  40                  45              


Pro Arg Glu Leu Arg Cys Ser Asp Cys Ile Val Trp Asn Arg Gln Gln 
    50                  55                  60                  


Thr Trp Leu Cys Val Val Pro Leu Phe Ile Gly Phe Ile Gly Leu Gly 
65                  70                  75                  80  


Leu Ser Leu Met Leu Leu Lys Trp Ile Val Val Gly Ser Val Lys Glu 
                85                  90                  95      


Tyr Val Pro Thr Asp Leu Val Asp Ser Lys Gly Met Gly Gln Asp Pro 
            100                 105                 110         


Phe Phe Leu Ser Lys Pro Ser Ser Phe Pro Lys Ala Met Glu Thr Thr 
        115                 120                 125             


Thr Thr Thr Thr Ser Thr Thr Ser Pro Ala Thr Pro Ser Ala Gly Gly 
    130                 135                 140                 


Ala Ala Ser Ser Arg Thr Pro Asn Arg Ile Ser Thr Arg Leu Thr Thr 
145                 150                 155                 160 


Ile Thr Arg Ala Pro Thr Arg Phe Pro Gly His Arg Val Pro Ile Arg 
                165                 170                 175     


Ala Ser Pro Arg Ser Thr Thr Ala Arg Asn Thr Ala Ala Pro Ala Thr 
            180                 185                 190         


Val Pro Ser Thr Thr Ala Pro Phe Phe Ser Ser Ser Thr Leu Gly Ser 
        195                 200                 205             


Arg Pro Pro Val Pro Gly Thr Pro Ser Thr Gln Ala Met Pro Ser Trp 
    210                 215                 220                 


Pro Thr Ala Ala Tyr Ala Thr Ser Ser Tyr Leu His Asp Ser Thr Pro 
225                 230                 235                 240 


Ser Trp Thr Leu Ser Pro Phe Gln Asp Ala Ala Ser Ser Ser Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Ala Thr Thr Thr Thr Pro Glu Thr Ser Ser Pro Lys 
            260                 265                 270         


Phe His Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu His Phe Lys Pro 
        275                 280                 285             


Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp Gly Glu Cys Phe 
    290                 295                 300                 


Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys Arg Cys Lys Glu 
305                 310                 315                 320 


Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro Lys Thr Asp Ser 
                325                 330                 335     


Ile Leu Ser Asp Pro Thr Asp His Leu Gly Ile Glu Phe Met Glu Ser 
            340                 345                 350         


Glu Glu Val Tyr Gln Arg 
        355             


<210>  19
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp Gly Glu Cys Phe 
1               5                   10                  15      


Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys Arg Cys Lys Glu 
            20                  25                  30          


Gly Tyr Gln Gly Val Arg Cys 
        35                  


<210>  20
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Thr Asp His Glu Glu Pro Cys Gly Pro Ser His Lys Ser Phe 
1               5                   10                  15      


Cys Leu Asn Gly Gly Leu Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro 
            20                  25                  30          


Phe Cys Arg Cys Val Glu Asn Tyr Thr Gly Ala Arg Cys Glu Glu Val 
        35                  40                  45              


Phe Leu Pro Gly Ser Ser Ile Gln Thr Lys Ser Asn Leu 
    50                  55                  60      


<210>  21
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Gly Pro Ser His Lys Ser Phe Cys Leu Asn Gly Gly Leu Cys Tyr 
1               5                   10                  15      


Val Ile Pro Thr Ile Pro Ser Pro Phe Cys Arg Cys Val Glu Asn Tyr 
            20                  25                  30          


Thr Gly Ala Arg Cys 
        35          


