                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  CHIMERIC ANTIGEN RECEPTORS TARGETING CD33

<130>  F053-0128PCT / 20-098-WO-PCT

<150>  US 63/003,213
<151>  2020-03-31

<160>  378   

<170>  PatentIn version 3.5

<210>  1
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7 scFv coding sequence

<400>  1
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccaag tacaacttca acaaagtgga gccgaactgg taaaacccgg agcgtctgtg      120

aagattagtt gcaaggcatc cggttacgcc ttctcaaatt attggatgaa ctgggtaaag      180

cagcggcccg gaaagggtct cgagtggatt gggcaaatca acccagggga cggggatacg      240

aactacaacg gtaagttcaa aggcaaggct acgttgacgg ctgataagag ctcaagcacc      300

gcttacatgc agttgtcttc tttgacaagt gaggatagtg ccgtttactt ctgcgcccga      360

gaggaccgag attattttga ttattggggc cagggaacaa ctctcaccgt cagctccgga      420

ggcggaggat ctggcggagg gggctctgga ggaggaggat ctgatattca gatgacccaa      480

actacgagtt ccctgtctgc cagccttggc gaccgggtca caattagttg cagggcttct      540

caggatatca actactattt gaactggtac cagcagaaac ctgatgggac ggtcaaactt      600

ctcatctact attcatccag actgcacagt ggcgtaccgt ctagattctc aggaagcggc      660

agtggtacgg attttagtct taccattagt aatctggaac aggaggacat cgccacgtat      720

ttttgccagc aggatgacgc actgccctat accttcggcg gaggcactaa gttggagata      780

aaa                                                                    783


<210>  2
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6H9 scFv coding sequence, codon optimized

<400>  2
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaag ttatgctcgt tgaaagcggt ggaggtctcg tcaaacccgg tggcagtctg      120

aagttgagct gtgcagcttc aggtttcact ttcagcagct acacaatgtc atgggttcgg      180

cagacaccag agaagcgctt ggaatgggtc gctacgattt ccggcgatgg aggcaacacc      240

tattattcag actcagtgaa aggacgattt acaatttcac gggacaacgc gaaaaatacg      300

ctttaccttc aaatgtcctc acttcgatct gaagataccg ctctttacta ttgcgctcga      360

caaggaactg gaacggatta cttcgactac tggggacaag gcaccactct tacggtctct      420

tctggaggcg gaggatctgg cggagggggc tctggaggag gaggatctga tatacagatg      480

acacagacca catcatcctt gtctgccagt ctgggcgacc gggtaactat cagttgcaga      540

gcgtctcagg atataaacat ttatctcaat tggtatcaac agaaaccgga cggtacagta      600

aagttgctca tttactacac aagcagattg cacagtggcg tgccgagtag attttctggg      660

tcaggtagcg gaactgatta cagtttgacc atctctaatt tggaacagga ggatattgcg      720

acttactttt gtcaacaggg agatacactt ccatggacat ttggcggggg gaccaaactc      780

gaaattaag                                                              789


<210>  3
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9G2 scFv coding sequence

<400>  3
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgagg tcaagcttgt cgagtcagag ggaggtttgg tccagccggg ttcttctatg      120

aaactctcct gcacagccag tggctttaca tttagtgatt actacatgag ttgggtgaga      180

caggtgcctg agaaagggct ggagtgggta gcttccatta actacgacgg aggtagcacc      240

tattacttgg actccttgaa aagcagattc ataatttcca gggataatac gaaaaacata      300

ctttatcttc aaatgtcctc tttgaagagc gaggacacag ccacatacta ttgcgccagg      360

gatagaggcg atggtgatta ttttgactat tggggacagg gcacaacact cacggtcagc      420

agcggaggcg gaggatctgg cggagggggc tctggaggag gaggatctga tatacaaatg      480

actcagacaa cgagcagttt gtccgcatct cttggcgatc gagtaactat tagctgcaag      540

acatcccagg acatatataa ttatttgaat tggtatcagc agaaaccgga cggaactgtc      600

aaactcctca tttattatac ctccaggctt catagtgggg ttccttcccg atttagtgga      660

ggaggctcag gtacggacta cagcctgacg atttccaacc ttgaacaaga agatatagct      720

acatacttct gtcagcaagg tgacaccttg ccctggacat tcggtggggg tacaaaactc      780

gaaataaag                                                              789


<210>  4
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D5 scFv coding sequence

<400>  4
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca gcagagcggc gcggaactgg tgcgcccggg cgcgagcgtg      120

accctgagct gcaaagcgag cggctatacc tttaccgatt atgatatgca ttgggtgaaa      180

cagaccccgg tgcatggcct ggaatggatt ggcgcgattg atccggaaac cggcggcacc      240

gcgtataacc agaactttaa aggcaaagcg attctgaccg tggataaaag cagccgcatt      300

gcgtatatgg aactgcgcag cctgaccagc gaagatagcg cggtgtttta ttgcaccagc      360

gattatgatt attttggcgt gtggggcacc ggcaccaccg tgaccgtgag cagcggaggc      420

ggaggatctg gcggaggggg ctctggagga ggaggatctg atattgtgat gacccagagc      480

cagaaattta tgagcaccag cgtgggcgat cgcgtgagcg tgacctgcaa agcgagccag      540

aacgtgggca ccaacgtggt gtggtatcat aaaaaaccgg gccagagccc gaaaggcctg      600

atttatagcg cgagcgatcg ctatagcggc gtgccggatc gctttaccgg cagcggcagc      660

ggcaccgatt ttaccctgac cattaacaac gtgcagagcg aagatctggc ggaatatttt      720

tgccagcagt ataacattta tccgtatacc tttggcggcg gcaccaaact ggaaattaaa      780


<210>  5
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D12 scFv coding sequence

<400>  5
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccaag ttcagttgca acaatcaggt gctgaggtgg taaagccagg tgccagtgtc      120

aaaatatctt gccgggcgtc tggttatgcg ttctccaact attggatgaa ctgggtaaaa      180

caacgcccag gtaagggact cgagtggata ggacaaatat acccaggcaa cttcaacaca      240

gactacaatg gtcaattcaa gggaaaggct actcttacag tcgataaatc ttcaaacacg      300

gcttacatgc agttgtcctc cttgacctcc gaggattcag cagtctattt ctgtgcccga      360

ttctttgatt ttggcgctta ttttacgttg gattattggg gccaagggac atctgtcaca      420

gtttcctccg gaggcggagg atctggcgga gggggctctg gaggaggagg atctgatata      480

aagatgactc agtcacccag cagtatatac gctagtctgg gagaaagggt cacgataaat      540

tgtaaggctt cacaagacat aaaaagttat ctttcatggt atcaacagaa accctggaaa      600

agccccaaga cccttatcta ctacgctacg actcttgcag atggtgtacc aagtcggttt      660

tccgggagcg gctccgggca agactattct ttgacaattt cctctttgga gtccgatgat      720

accgcaacct actactgcct gcatcacggt gagtcaccat ggacatttgg cgaagggaca      780

aagcttgaaa taaag                                                       795


<210>  6
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge coding sequence-A

<400>  6
gagtctaagt acggaccgcc ctgcccccct tgccct                                 36


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge coding sequence-B

<400>  7
gagtctaagt acggaccgcc ttgcccaccg tgccca                                 36


<210>  8
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4-int(DS) coding sequence

<400>  8
ggccagccta gagaacccca ggtgtacacc ctgcctccca gccaggaaga gatgaccaag       60

aaccaggtgt ccctgacctg cctggtcaaa ggcttctacc ccagcgatat cgccgtggaa      120

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc      180

gacggcagct tcttcctgta ctcccggctg accgtggaca agagccggtg gcaggaaggc      240

aacgtcttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc      300

ctgagcctga gcctgggcaa g                                                321


<210>  9
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4-long coding sequence

<400>  9
gcaccacctg tggcaggacc gtcagtcttc ctcttcccac caaaacccaa ggacaccctg       60

atgatcagcc ggacccccga ggtgacctgc gtggtggtgg acgtgagcca ggaagatccc      120

gaggtccagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      180

agagaggaac agttccaaag cacctaccgg gtggtgtctg tgctgaccgt gctgcaccag      240

gactggctga acggcaaaga atacaagtgc aaggtgtcca acaagggcct gcccagcagc      300

atcgaaaaga ccatcagcaa ggccaagggc cagcctcgcg agccccaggt gtacaccctg      360

cctccctccc aggaagagat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc      420

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac      480

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag ccggctgacc      540

gtggacaaga gccggtggca ggaaggcaac gtctttagct gcagcgtgat gcacgaggcc      600

ctgcacaacc actacaccca gaagagcctg agcctgtccc tgggcaag                   648


<210>  10
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3z coding sequence

<400>  10
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg       60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc      120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc ccaagg                                336


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z protein - A

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z protein -B

<400>  12

Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            20                  25                  30          


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        35                  40                  45              


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  13
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB signaling coding sequence-A

<400>  13
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  14
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB signaling coding sequence-B

<400>  14
gtgaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta       60

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga      120

tgtgaactg                                                              129


<210>  15
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB protein-A

<400>  15

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40              


<210>  16
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB protein-B

<400>  16

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        35                  40      


<210>  17
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28TM coding sequence-A

<400>  17
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc       60

gtggccttca tcatcttttg ggtg                                              84


<210>  18
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28TM coding sequence-B

<400>  18
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc       60

gtggccttca tcatcttttg g                                                 81


<210>  19
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28TM coding sequence-C

<400>  19
atgttctggg tgctggtggt ggtgggcggg gtgctggcct gctacagcct gctggtgaca       60

gtggccttca tcatcttttg g                                                 81


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28TM protein-A

<400>  20

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25          


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28TM protein-B

<400>  21

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25      


<210>  22
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tCD19 coding sequence

<400>  22
atgccacctc caagactcct cttcttcctc ctcttcctga caccaatgga agtcaggcct       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgttaca gtgcctcaag      120

ggaacctcag atggacccac tcagcagctg acctggtctc gggagtctcc gcttaaaccc      180

ttcctgaaac tcagccttgg actgccaggt ctgggaatcc acatgaggcc actggctatc      240

tggctgttca tcttcaacgt ctctcaacag atgggaggct tctacctgtg tcagcctgga      300

ccaccttctg agaaggcatg gcagcctggt tggacagtca atgtggaggg ttctggtgag      360

ctgttccggt ggaatgtttc ggacctaggt ggactgggat gtggtctgaa gaacaggtcc      420

tcagagggac ctagctctcc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gccctgccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagat ga                                                          972


<210>  23
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A coding sequence

<400>  23
ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat       60

ccaggcccta gg                                                           72


<210>  24
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  24

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  25
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  25

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  26

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  27
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  27

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  28
<211>  544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1 promoter-A

<400>  28
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctac                                                                   544


<210>  29
<211>  545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1 promoter-B

<400>  29
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacg                                                                  545


<210>  30
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Psi

<400>  30
ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg agtacgccaa       60

aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc agt             113


<210>  31
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RRE

<400>  31
gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt       60

gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag      120

gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag      180

gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc      240

ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga      300

aaactcattt gcaccactgc tgtgccttgg atc                                   333


<210>  32
<211>  179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flap

<400>  32
tacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg       60

caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac      120

aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccagtttgg       179


<210>  33
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GM-CSFR encoding sequence

<400>  33
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccc                                                                  66


<210>  34
<211>  601
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  34
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcatcga      600

t                                                                      601


<210>  35
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  delU3

<400>  35
gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt tttaaaagaa       60

aaggggggac tggaagggct aattcactcc caaagaagac aagat                      105


<210>  36
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R

<400>  36
ctgctttttg cctgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct       60

ggctaactag ggaacccact g                                                 81


<210>  37
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U5

<400>  37
cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt       60

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctct            114


<210>  38
<211>  859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AmpR

<400>  38
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattggt                                                   859


<210>  39
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoE1 origin

<400>  39
aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag       60

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct      120

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt      180

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg      240

cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct      300

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc      360

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg      420

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa      480

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg      540

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg      600

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga      660

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt      720

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct      780

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga      840

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag ag                         882


<210>  40
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40

<400>  40
ggtcgagatc cggtcgacca gcaaccatag tcccgcccct aactccgccc atcccgcccc       60

taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg      120

cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg      180

gaggcctagg cttttgcaaa                                                  200


<210>  41
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV

<400>  41
atcgattggc tcatgtccaa cattaccgcc atgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggaattc      600


<210>  42
<211>  3285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7-intDS-41bb-3z-T-CD19t Top Strand

<400>  42
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaagtacaa cttcaacaaa gtggagccga actggtaaaa      660

cccggagcgt ctgtgaagat tagttgcaag gcatccggtt acgccttctc aaattattgg      720

atgaactggg taaagcagcg gcccggaaag ggtctcgagt ggattgggca aatcaaccca      780

ggggacgggg atacgaacta caacggtaag ttcaaaggca aggctacgtt gacggctgat      840

aagagctcaa gcaccgctta catgcagttg tcttctttga caagtgagga tagtgccgtt      900

tacttctgcg cccgagagga ccgagattat tttgattatt ggggccaggg aacaactctc      960

accgtcagct ccggaggcgg aggatctggc ggagggggct ctggaggagg aggatctgat     1020

attcagatga cccaaactac gagttccctg tctgccagcc ttggcgaccg ggtcacaatt     1080

agttgcaggg cttctcagga tatcaactac tatttgaact ggtaccagca gaaacctgat     1140

gggacggtca aacttctcat ctactattca tccagactgc acagtggcgt accgtctaga     1200

ttctcaggaa gcggcagtgg tacggatttt agtcttacca ttagtaatct ggaacaggag     1260

gacatcgcca cgtatttttg ccagcaggat gacgcactgc cctatacctt cggcggaggc     1320

actaagttgg agataaaaga gtctaagtac ggaccgccct gccccccttg ccctggccag     1380

cctagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag     1440

gtgtccctga cctgcctggt caaaggcttc taccccagcg atatcgccgt ggaatgggag     1500

agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1560

agcttcttcc tgtactcccg gctgaccgtg gacaagagcc ggtggcagga aggcaacgtc     1620

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1680

ctgagcctgg gcaagatgtt ctgggtgctg gtggtggtcg gaggcgtgct ggcctgctac     1740

agcctgctgg tcaccgtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     1800

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1860

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     1920

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     1980

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     2040

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     2100

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     2160

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     2220

atgcaggccc tgcccccaag gctcgagggc ggcggagagg gcagaggaag tcttctaaca     2280

tgcggtgacg tggaggagaa tccaggccct aggatgccac ctccaagact cctcttcttc     2340

ctcctcttcc tgacaccaat ggaagtcagg cctgaggaac ctctagtggt gaaggtggaa     2400

gagggagata acgctgtgtt acagtgcctc aagggaacct cagatggacc cactcagcag     2460

ctgacctggt ctcgggagtc tccgcttaaa cccttcctga aactcagcct tggactgcca     2520

ggtctgggaa tccacatgag gccactggct atctggctgt tcatcttcaa cgtctctcaa     2580

cagatgggag gcttctacct gtgtcagcct ggaccacctt ctgagaaggc atggcagcct     2640

ggttggacag tcaatgtgga gggttctggt gagctgttcc ggtggaatgt ttcggaccta     2700

ggtggactgg gatgtggtct gaagaacagg tcctcagagg gacctagctc tccttccggg     2760

aagctcatga gccccaagct gtatgtgtgg gccaaagacc gccctgagat ctgggaggga     2820

gagcctccgt gtgtcccacc gagggacagc ctgaaccaga gcctcagcca ggacctcacc     2880

atggcccctg gctccacact ctggctgtcc tgtggggtac cccctgactc tgtgtccagg     2940

ggccccctct cctggaccca tgtgcacccc aaggggccta agtcattgct gagcctagag     3000

ctgaaggacg atcgccctgc cagagatatg tgggtaatgg agacgggtct gttgttgccc     3060

cgggccacag ctcaagacgc tggaaagtat tattgtcacc gtggcaacct gaccatgtca     3120

ttccacctgg agatcactgc tcggccagta ctatggcact ggctgctgag gactggtggc     3180

tggaaggtct cagctgtgac tttggcttat ctgatcttct gcctgtgttc ccttgtgggc     3240

attcttcatc ttcaaagagc cctggtcctg aggaggaaaa gatga                     3285


<210>  43
<211>  3612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7-long-41bb-3z-T-CD19t Top Strand

<400>  43
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaagtacaa cttcaacaaa gtggagccga actggtaaaa      660

cccggagcgt ctgtgaagat tagttgcaag gcatccggtt acgccttctc aaattattgg      720

atgaactggg taaagcagcg gcccggaaag ggtctcgagt ggattgggca aatcaaccca      780

ggggacgggg atacgaacta caacggtaag ttcaaaggca aggctacgtt gacggctgat      840

aagagctcaa gcaccgctta catgcagttg tcttctttga caagtgagga tagtgccgtt      900

tacttctgcg cccgagagga ccgagattat tttgattatt ggggccaggg aacaactctc      960

accgtcagct ccggaggcgg aggatctggc ggagggggct ctggaggagg aggatctgat     1020

attcagatga cccaaactac gagttccctg tctgccagcc ttggcgaccg ggtcacaatt     1080

agttgcaggg cttctcagga tatcaactac tatttgaact ggtaccagca gaaacctgat     1140

gggacggtca aacttctcat ctactattca tccagactgc acagtggcgt accgtctaga     1200

ttctcaggaa gcggcagtgg tacggatttt agtcttacca ttagtaatct ggaacaggag     1260

gacatcgcca cgtatttttg ccagcaggat gacgcactgc cctatacctt cggcggaggc     1320

actaagttgg agataaaaga gtctaagtac ggaccgcctt gcccaccgtg cccagcacca     1380

cctgtggcag gaccgtcagt cttcctcttc ccaccaaaac ccaaggacac cctgatgatc     1440

agccggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccaggaaga tcccgaggtc     1500

cagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag     1560

gaacagttcc aaagcaccta ccgggtggtg tctgtgctga ccgtgctgca ccaggactgg     1620

ctgaacggca aagaatacaa gtgcaaggtg tccaacaagg gcctgcccag cagcatcgaa     1680

aagaccatca gcaaggccaa gggccagcct cgcgagcccc aggtgtacac cctgcctccc     1740

tcccaggaag agatgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac     1800

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1860

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagccggct gaccgtggac     1920

aagagccggt ggcaggaagg caacgtcttt agctgcagcg tgatgcacga ggccctgcac     1980

aaccactaca cccagaagag cctgagcctg tccctgggca agatgttctg ggtgctggtg     2040

gtggtgggcg gggtgctggc ctgctacagc ctgctggtga cagtggcctt catcatcttt     2100

tgggtgaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     2160

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     2220

ggatgtgaac tgcgggtgaa gttcagcaga agcgccgacg cccctgccta ccagcagggc     2280

cagaatcagc tgtacaacga gctgaacctg ggcagaaggg aagagtacga cgtcctggat     2340

aagcggagag gccgggaccc tgagatgggc ggcaagcctc ggcggaagaa cccccaggaa     2400

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     2460

aagggcgagc ggaggcgggg caagggccac gacggcctgt atcagggcct gtccaccgcc     2520

accaaggata cctacgacgc cctgcacatg caggccctgc ccccaaggct cgagggcggc     2580

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc aggccctagg     2640

atgccacctc caagactcct cttcttcctc ctcttcctga caccaatgga agtcaggcct     2700

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgttaca gtgcctcaag     2760

ggaacctcag atggacccac tcagcagctg acctggtctc gggagtctcc gcttaaaccc     2820

ttcctgaaac tcagccttgg actgccaggt ctgggaatcc acatgaggcc actggctatc     2880

tggctgttca tcttcaacgt ctctcaacag atgggaggct tctacctgtg tcagcctgga     2940

ccaccttctg agaaggcatg gcagcctggt tggacagtca atgtggaggg ttctggtgag     3000

ctgttccggt ggaatgtttc ggacctaggt ggactgggat gtggtctgaa gaacaggtcc     3060

tcagagggac ctagctctcc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc     3120

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg     3180

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt     3240

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag     3300

gggcctaagt cattgctgag cctagagctg aaggacgatc gccctgccag agatatgtgg     3360

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat     3420

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta     3480

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg     3540

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg     3600

aggaaaagat ga                                                         3612


<210>  44
<211>  2964
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7-sh-41bb-3z-T-CD19t Top Strand

<400>  44
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaagtacaa cttcaacaaa gtggagccga actggtaaaa      660

cccggagcgt ctgtgaagat tagttgcaag gcatccggtt acgccttctc aaattattgg      720

atgaactggg taaagcagcg gcccggaaag ggtctcgagt ggattgggca aatcaaccca      780

ggggacgggg atacgaacta caacggtaag ttcaaaggca aggctacgtt gacggctgat      840

aagagctcaa gcaccgctta catgcagttg tcttctttga caagtgagga tagtgccgtt      900

tacttctgcg cccgagagga ccgagattat tttgattatt ggggccaggg aacaactctc      960

accgtcagct ccggaggcgg aggatctggc ggagggggct ctggaggagg aggatctgat     1020

attcagatga cccaaactac gagttccctg tctgccagcc ttggcgaccg ggtcacaatt     1080

agttgcaggg cttctcagga tatcaactac tatttgaact ggtaccagca gaaacctgat     1140

gggacggtca aacttctcat ctactattca tccagactgc acagtggcgt accgtctaga     1200

ttctcaggaa gcggcagtgg tacggatttt agtcttacca ttagtaatct ggaacaggag     1260

gacatcgcca cgtatttttg ccagcaggat gacgcactgc cctatacctt cggcggaggc     1320

actaagttgg agataaaaga gtctaagtac ggaccgccct gccccccttg ccctatgttc     1380

tgggtgctgg tggtggtcgg aggcgtgctg gcctgctaca gcctgctggt caccgtggcc     1440

ttcatcatct tttgggtgaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1500

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1560

gaagaagaag gaggatgtga actgcgggtg aagttcagca gaagcgccga cgcccctgcc     1620

taccagcagg gccagaatca gctgtacaac gagctgaacc tgggcagaag ggaagagtac     1680

gacgtcctgg ataagcggag aggccgggac cctgagatgg gcggcaagcc tcggcggaag     1740

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1800

gagatcggca tgaagggcga gcggaggcgg ggcaagggcc acgacggcct gtatcagggc     1860

ctgtccaccg ccaccaagga tacctacgac gccctgcaca tgcaggccct gcccccaagg     1920

ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat     1980

ccaggcccta ggatgccacc tccaagactc ctcttcttcc tcctcttcct gacaccaatg     2040

gaagtcaggc ctgaggaacc tctagtggtg aaggtggaag agggagataa cgctgtgtta     2100

cagtgcctca agggaacctc agatggaccc actcagcagc tgacctggtc tcgggagtct     2160

ccgcttaaac ccttcctgaa actcagcctt ggactgccag gtctgggaat ccacatgagg     2220

ccactggcta tctggctgtt catcttcaac gtctctcaac agatgggagg cttctacctg     2280

tgtcagcctg gaccaccttc tgagaaggca tggcagcctg gttggacagt caatgtggag     2340

ggttctggtg agctgttccg gtggaatgtt tcggacctag gtggactggg atgtggtctg     2400

aagaacaggt cctcagaggg acctagctct ccttccggga agctcatgag ccccaagctg     2460

tatgtgtggg ccaaagaccg ccctgagatc tgggagggag agcctccgtg tgtcccaccg     2520

agggacagcc tgaaccagag cctcagccag gacctcacca tggcccctgg ctccacactc     2580

tggctgtcct gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat     2640

gtgcacccca aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgccctgcc     2700

agagatatgt gggtaatgga gacgggtctg ttgttgcccc gggccacagc tcaagacgct     2760

ggaaagtatt attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct     2820

cggccagtac tatggcactg gctgctgagg actggtggct ggaaggtctc agctgtgact     2880

ttggcttatc tgatcttctg cctgtgttcc cttgtgggca ttcttcatct tcaaagagcc     2940

ctggtcctga ggaggaaaag atga                                            2964


<210>  45
<211>  3291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6H9-intDS-41bb-3z-T-CD19t Top Strand

<400>  45
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgaagttatg ctcgttgaaa gcggtggagg tctcgtcaaa      660

cccggtggca gtctgaagtt gagctgtgca gcttcaggtt tcactttcag cagctacaca      720

atgtcatggg ttcggcagac accagagaag cgcttggaat gggtcgctac gatttccggc      780

gatggaggca acacctatta ttcagactca gtgaaaggac gatttacaat ttcacgggac      840

aacgcgaaaa atacgcttta ccttcaaatg tcctcacttc gatctgaaga taccgctctt      900

tactattgcg ctcgacaagg aactggaacg gattacttcg actactgggg acaaggcacc      960

actcttacgg tctcttctgg aggcggagga tctggcggag ggggctctgg aggaggagga     1020

tctgatatac agatgacaca gaccacatca tccttgtctg ccagtctggg cgaccgggta     1080

actatcagtt gcagagcgtc tcaggatata aacatttatc tcaattggta tcaacagaaa     1140

ccggacggta cagtaaagtt gctcatttac tacacaagca gattgcacag tggcgtgccg     1200

agtagatttt ctgggtcagg tagcggaact gattacagtt tgaccatctc taatttggaa     1260

caggaggata ttgcgactta cttttgtcaa cagggagata cacttccatg gacatttggc     1320

ggggggacca aactcgaaat taaggagtct aagtacggac cgccctgccc cccttgccct     1380

ggccagccta gagaacccca ggtgtacacc ctgcctccca gccaggaaga gatgaccaag     1440

aaccaggtgt ccctgacctg cctggtcaaa ggcttctacc ccagcgatat cgccgtggaa     1500

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1560

gacggcagct tcttcctgta ctcccggctg accgtggaca agagccggtg gcaggaaggc     1620

aacgtcttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1680

ctgagcctga gcctgggcaa gatgttctgg gtgctggtgg tggtcggagg cgtgctggcc     1740

tgctacagcc tgctggtcac cgtggccttc atcatctttt gggtgaaacg gggcagaaag     1800

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1860

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgggtgaag     1920

ttcagcagaa gcgccgacgc ccctgcctac cagcagggcc agaatcagct gtacaacgag     1980

ctgaacctgg gcagaaggga agagtacgac gtcctggata agcggagagg ccgggaccct     2040

gagatgggcg gcaagcctcg gcggaagaac ccccaggaag gcctgtataa cgaactgcag     2100

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcggggc     2160

aagggccacg acggcctgta tcagggcctg tccaccgcca ccaaggatac ctacgacgcc     2220

ctgcacatgc aggccctgcc cccaaggctc gagggcggcg gagagggcag aggaagtctt     2280

ctaacatgcg gtgacgtgga ggagaatcca ggccctagga tgccacctcc aagactcctc     2340

ttcttcctcc tcttcctgac accaatggaa gtcaggcctg aggaacctct agtggtgaag     2400

gtggaagagg gagataacgc tgtgttacag tgcctcaagg gaacctcaga tggacccact     2460

cagcagctga cctggtctcg ggagtctccg cttaaaccct tcctgaaact cagccttgga     2520

ctgccaggtc tgggaatcca catgaggcca ctggctatct ggctgttcat cttcaacgtc     2580

tctcaacaga tgggaggctt ctacctgtgt cagcctggac caccttctga gaaggcatgg     2640

cagcctggtt ggacagtcaa tgtggagggt tctggtgagc tgttccggtg gaatgtttcg     2700

gacctaggtg gactgggatg tggtctgaag aacaggtcct cagagggacc tagctctcct     2760

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     2820

gagggagagc ctccgtgtgt cccaccgagg gacagcctga accagagcct cagccaggac     2880

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2940

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     3000

ctagagctga aggacgatcg ccctgccaga gatatgtggg taatggagac gggtctgttg     3060

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     3120

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     3180

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     3240

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagatg a              3291


<210>  46
<211>  3291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9G2-intDS-41bb-3z-T-CD19t Top Strand

<400>  46
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgaggtcaag cttgtcgagt cagagggagg tttggtccag      660

ccgggttctt ctatgaaact ctcctgcaca gccagtggct ttacatttag tgattactac      720

atgagttggg tgagacaggt gcctgagaaa gggctggagt gggtagcttc cattaactac      780

gacggaggta gcacctatta cttggactcc ttgaaaagca gattcataat ttccagggat      840

aatacgaaaa acatacttta tcttcaaatg tcctctttga agagcgagga cacagccaca      900

tactattgcg ccagggatag aggcgatggt gattattttg actattgggg acagggcaca      960

acactcacgg tcagcagcgg aggcggagga tctggcggag ggggctctgg aggaggagga     1020

tctgatatac aaatgactca gacaacgagc agtttgtccg catctcttgg cgatcgagta     1080

actattagct gcaagacatc ccaggacata tataattatt tgaattggta tcagcagaaa     1140

ccggacggaa ctgtcaaact cctcatttat tatacctcca ggcttcatag tggggttcct     1200

tcccgattta gtggaggagg ctcaggtacg gactacagcc tgacgatttc caaccttgaa     1260

caagaagata tagctacata cttctgtcag caaggtgaca ccttgccctg gacattcggt     1320

gggggtacaa aactcgaaat aaaggagtct aagtacggac cgccctgccc cccttgccct     1380

ggccagccta gagaacccca ggtgtacacc ctgcctccca gccaggaaga gatgaccaag     1440

aaccaggtgt ccctgacctg cctggtcaaa ggcttctacc ccagcgatat cgccgtggaa     1500

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1560

gacggcagct tcttcctgta ctcccggctg accgtggaca agagccggtg gcaggaaggc     1620

aacgtcttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1680

ctgagcctga gcctgggcaa gatgttctgg gtgctggtgg tggtcggagg cgtgctggcc     1740

tgctacagcc tgctggtcac cgtggccttc atcatctttt gggtgaaacg gggcagaaag     1800

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1860

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgggtgaag     1920

ttcagcagaa gcgccgacgc ccctgcctac cagcagggcc agaatcagct gtacaacgag     1980

ctgaacctgg gcagaaggga agagtacgac gtcctggata agcggagagg ccgggaccct     2040

gagatgggcg gcaagcctcg gcggaagaac ccccaggaag gcctgtataa cgaactgcag     2100

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcggggc     2160

aagggccacg acggcctgta tcagggcctg tccaccgcca ccaaggatac ctacgacgcc     2220

ctgcacatgc aggccctgcc cccaaggctc gagggcggcg gagagggcag aggaagtctt     2280

ctaacatgcg gtgacgtgga ggagaatcca ggccctagga tgccacctcc aagactcctc     2340

ttcttcctcc tcttcctgac accaatggaa gtcaggcctg aggaacctct agtggtgaag     2400

gtggaagagg gagataacgc tgtgttacag tgcctcaagg gaacctcaga tggacccact     2460

cagcagctga cctggtctcg ggagtctccg cttaaaccct tcctgaaact cagccttgga     2520

ctgccaggtc tgggaatcca catgaggcca ctggctatct ggctgttcat cttcaacgtc     2580

tctcaacaga tgggaggctt ctacctgtgt cagcctggac caccttctga gaaggcatgg     2640

cagcctggtt ggacagtcaa tgtggagggt tctggtgagc tgttccggtg gaatgtttcg     2700

gacctaggtg gactgggatg tggtctgaag aacaggtcct cagagggacc tagctctcct     2760

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     2820

gagggagagc ctccgtgtgt cccaccgagg gacagcctga accagagcct cagccaggac     2880

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2940

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     3000

ctagagctga aggacgatcg ccctgccaga gatatgtggg taatggagac gggtctgttg     3060

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     3120

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     3180

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     3240

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagatg a              3291


<210>  47
<211>  3297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D12-intDS-41bb-3z-T-CD19t Top Strand

<400>  47
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaagttcag ttgcaacaat caggtgctga ggtggtaaag      660

ccaggtgcca gtgtcaaaat atcttgccgg gcgtctggtt atgcgttctc caactattgg      720

atgaactggg taaaacaacg cccaggtaag ggactcgagt ggataggaca aatataccca      780

ggcaacttca acacagacta caatggtcaa ttcaagggaa aggctactct tacagtcgat      840

aaatcttcaa acacggctta catgcagttg tcctccttga cctccgagga ttcagcagtc      900

tatttctgtg cccgattctt tgattttggc gcttatttta cgttggatta ttggggccaa      960

gggacatctg tcacagtttc ctccggaggc ggaggatctg gcggaggggg ctctggagga     1020

ggaggatctg atataaagat gactcagtca cccagcagta tatacgctag tctgggagaa     1080

agggtcacga taaattgtaa ggcttcacaa gacataaaaa gttatctttc atggtatcaa     1140

cagaaaccct ggaaaagccc caagaccctt atctactacg ctacgactct tgcagatggt     1200

gtaccaagtc ggttttccgg gagcggctcc gggcaagact attctttgac aatttcctct     1260

ttggagtccg atgataccgc aacctactac tgcctgcatc acggtgagtc accatggaca     1320

tttggcgaag ggacaaagct tgaaataaag gagtctaagt acggaccgcc ctgcccccct     1380

tgccctggcc agcctagaga accccaggtg tacaccctgc ctcccagcca ggaagagatg     1440

accaagaacc aggtgtccct gacctgcctg gtcaaaggct tctaccccag cgatatcgcc     1500

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg     1560

gacagcgacg gcagcttctt cctgtactcc cggctgaccg tggacaagag ccggtggcag     1620

gaaggcaacg tcttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1680

aagtccctga gcctgagcct gggcaagatg ttctgggtgc tggtggtggt cggaggcgtg     1740

ctggcctgct acagcctgct ggtcaccgtg gccttcatca tcttttgggt gaaacggggc     1800

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1860

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgcgg     1920

gtgaagttca gcagaagcgc cgacgcccct gcctaccagc agggccagaa tcagctgtac     1980

aacgagctga acctgggcag aagggaagag tacgacgtcc tggataagcg gagaggccgg     2040

gaccctgaga tgggcggcaa gcctcggcgg aagaaccccc aggaaggcct gtataacgaa     2100

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggagg     2160

cggggcaagg gccacgacgg cctgtatcag ggcctgtcca ccgccaccaa ggatacctac     2220

gacgccctgc acatgcaggc cctgccccca aggctcgagg gcggcggaga gggcagagga     2280

agtcttctaa catgcggtga cgtggaggag aatccaggcc ctaggatgcc acctccaaga     2340

ctcctcttct tcctcctctt cctgacacca atggaagtca ggcctgagga acctctagtg     2400

gtgaaggtgg aagagggaga taacgctgtg ttacagtgcc tcaagggaac ctcagatgga     2460

cccactcagc agctgacctg gtctcgggag tctccgctta aacccttcct gaaactcagc     2520

cttggactgc caggtctggg aatccacatg aggccactgg ctatctggct gttcatcttc     2580

aacgtctctc aacagatggg aggcttctac ctgtgtcagc ctggaccacc ttctgagaag     2640

gcatggcagc ctggttggac agtcaatgtg gagggttctg gtgagctgtt ccggtggaat     2700

gtttcggacc taggtggact gggatgtggt ctgaagaaca ggtcctcaga gggacctagc     2760

tctccttccg ggaagctcat gagccccaag ctgtatgtgt gggccaaaga ccgccctgag     2820

atctgggagg gagagcctcc gtgtgtccca ccgagggaca gcctgaacca gagcctcagc     2880

caggacctca ccatggcccc tggctccaca ctctggctgt cctgtggggt accccctgac     2940

tctgtgtcca ggggccccct ctcctggacc catgtgcacc ccaaggggcc taagtcattg     3000

ctgagcctag agctgaagga cgatcgccct gccagagata tgtgggtaat ggagacgggt     3060

ctgttgttgc cccgggccac agctcaagac gctggaaagt attattgtca ccgtggcaac     3120

ctgaccatgt cattccacct ggagatcact gctcggccag tactatggca ctggctgctg     3180

aggactggtg gctggaaggt ctcagctgtg actttggctt atctgatctt ctgcctgtgt     3240

tcccttgtgg gcattcttca tcttcaaaga gccctggtcc tgaggaggaa aagatga        3297


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fist 6 aa of CH2 domain of IgG4

<400>  48

Ala Pro Glu Phe Leu Gly 
1               5       


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First 5 aa of IgG2

<400>  49

Ala Pro Pro Val Ala 
1               5   


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H7

<400>  50

Arg Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn 
1               5                   10      


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H7

<400>  51

Tyr Tyr Ser Ser Arg Leu His Ser 
1               5               


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1H7

<400>  52

Gln Gln Asp Asp Ala Leu Pro Tyr Thr 
1               5                   


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7

<400>  53

Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10              


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  54

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H7

<400>  55

Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 6H9

<400>  56

Arg Ala Ser Gln Asp Ile Asn Ile Tyr Leu Asn 
1               5                   10      


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 6H9, 9G2, and/or 11D11

<400>  57

Tyr Tyr Thr Ser Arg Leu His Ser 
1               5               


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 6H9 and/or 9G2

<400>  58

Gln Gln Gly Asp Thr Leu Pro Trp Thr 
1               5                   


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  59

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser 
1               5                   10              


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  60

Thr Ile Ser Gly Asp Gly Gly Asn Thr Tyr 
1               5                   10  


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 6H9

<400>  61

Ala Arg Gln Gly Thr Gly Thr Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 9G2

<400>  62

Lys Thr Ser Gln Asp Ile Tyr Asn Tyr Leu Asn 
1               5                   10      


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  63

Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   10              


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  64

Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 9G2

<400>  65

Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D5

<400>  66

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Val 
1               5                   10      


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2D5

<400>  67

Tyr Ser Ala Ser Asp Arg Tyr Ser 
1               5               


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 2D5, 3A5v1, and/or 3A5v2

<400>  68

Gln Gln Tyr Asn Ile Tyr Pro Tyr Thr 
1               5                   


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5

<400>  69

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp Met His 
1               5                   10              


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  70

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala 
1               5                   10  


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D5

<400>  71

Thr Ser Asp Tyr Asp Tyr Phe Gly Val 
1               5                   


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 5D12

<400>  72

Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser 
1               5                   10      


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 5D12

<400>  73

Tyr Ala Thr Thr Leu Ala Asp 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 5D12

<400>  74

Leu His His Gly Glu Ser Pro Trp Thr 
1               5                   


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 5D12

<400>  75

Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10  


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  76

Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 5D12

<400>  77

Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr Val 
1               5                   10              


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  (GlyGlyGlyGlySer) can be repeated n times, wherein n is an 
       integer of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  78

Gly Gly Gly Gly Ser 
1               5   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  (GlyGlyGlyGlySer) can be repeated n times, wherein n is an 
       integer of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  79

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<220>
<221>  MISC_FEATURE
<222>  (5)..(7)
<223>  (GlyGlySer) can be repeated n times, wherein n is an integer of 
       1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  80

Gly Gly Gly Ser Gly Gly Ser 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  81

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  82
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  82

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  83

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  84

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  85

Gly Gly Gly Gly Ser 
1               5   


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  86

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  87

Gly Gly Gly Ser 
1               


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  88

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  89

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  90

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  91

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Entire sequence can be repeated n times, wherein n is an integer 
       including 1, 2, 3, 4, 5, 6, 7, 8, 9, or more

<400>  92

Glu Ala Ala Ala Lys 
1               5   


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  93

His His His His His His 
1               5       


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  94

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  95

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  96

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  97
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin tag

<400>  97

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  98

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  99

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag

<400>  100

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag II

<400>  101

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  102
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  102

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  103

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  104

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  105
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 4D protein

<400>  105

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly 
145                 150                 155                 160 


Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser Trp 
                165                 170                 175     


Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala Ala 
            180                 185                 190         


Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile Ile 
        195                 200                 205             


Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu Asn Val 
225                 230                 235                 240 


Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly Asp Gly 
                245                 250                 255     


Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Pro Glu Pro Ser 
            260                 265                 270         


Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu 
        275                 280                 285             


Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp 
    290                 295                 300                 


Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His 
305                 310                 315                 320 


Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala 
                325                 330                 335     


Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp 
            340                 345                 350         


Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met 
        355                 360                 365             


Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser 
    370                 375                 380                 


Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp 
385                 390                 395                 400 


Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp 
                405                 410                 415     


Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala 
            420                 425                 430         


Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val 
        435                 440                 445             


Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser 
    450                 455                 460                 


Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe 
465                 470                 475                 480 


Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe 
                485                 490                 495     


Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn 
            500                 505                 510         


Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu 
        515                 520                 525             


Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val 
    530                 535                 540                 


Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro 
545                 550                 555                 560 


Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro 
                565                 570                 575     


Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser 
            580                 585                 590         


Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser 
        595                 600                 605             


Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Gly Ala Ile 
    610                 615                 620                 


Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu Ile 
625                 630                 635                 640 


Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val 
                645                 650                 655     


Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His 
            660                 665                 670         


Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser 
        675                 680                 685             


Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser 
    690                 695                 700                 


Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr 
705                 710                 715                 720 


Ser Glu Val Arg Thr Gln 
                725     


<210>  106
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 4D nucleotides

<400>  106
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacagacttg acccacaggc ccaaaatcct catccctggc      480

actctagaac ccggccactc caaaaacctg acctgctctg tgtcctgggc ctgtgagcag      540

ggaacacccc cgatcttctc ctggttgtca gctgccccca cctccctggg ccccaggact      600

actcactcct cggtgctcat aatcacccca cggccccagg accacggcac caacctgacc      660

tgtcaggtga agttcgctgg agctggtgtg actacggaga gaaccatcca gctgaacgtc      720

acctatgttc cacagaaccc aacaactggt atctttccag gagatggctc agggaaacaa      780

gagaccagag caggagtggt tcatccggaa ccttccacgg ttcagatcct ccactcaccg      840

gctgtggagg gaagtcaagt cgagtttctt tgcatgtcac tggccaatcc tcttccaaca      900

aattacacgt ggtaccacaa tgggaaagaa atgcagggaa ggacagagga gaaagtccac      960

atcccaaaga tcctcccttg gcacgctggg acttattcct gtgtggcaga aaacattctt     1020

ggtactggac agaggggccc tggagctgag ctggatgtcc agtatcctcc caagaaggtg     1080

accacagtga ttcaaaaccc catgccgatt cgagaaggag acacagtgac cctttcctgt     1140

aactacaatt ccagtaaccc cagtgttacc cggtatgaat ggaaacccca tggcgcctgg     1200

gaggagccat cgcttggggt gctgaagatc caaaacgttg gctgggacaa cacaaccatc     1260

gcctgcgcag cttgtaatag ttggtgctcg tgggcctccc ctgtcgccct gaatgtccag     1320

tatgcccccc gagacgtgag ggtccggaaa atcaagcccc tttccgagat tcactctgga     1380

aactcggtca gcctccaatg tgacttctca agcagccacc ccaaagaagt ccagttcttc     1440

tgggagaaaa atggcaggct tctggggaaa gaaagccagc tgaattttga ctccatctcc     1500

ccagaagatg ctgggagtta cagctgctgg gtgaacaact ccataggaca gacagcgtcc     1560

aaggcctgga cacttgaagt gctgtatgca cccaggaggc tgcgtgtgtc catgagccca     1620

ggggaccaag tgatggaggg gaagagtgca accctgacct gtgagagcga cgccaaccct     1680

cccgtctccc actacacctg gtttgactgg aataaccaaa gcctccccta ccacagccag     1740

aagctgagat tggagccggt gaaggtccag cactcgggtg cctactggtg ccaggggacc     1800

aacagtgtgg gcaagggccg ttcgcctctc agcaccctca ccgtctacta tagcccggag     1860

accggggcca ttggaggagc tggtgttaca gccctgctcg ctctttgtct ctgcctcatc     1920

ttcttcatag tgaagaccca caggaggaaa gcagccagga cagcagtggg caggaatgac     1980

acccacccta ccacagggtc agcctccccg aaacaccaga agaagtccaa gttacatggc     2040

cccactgaaa cctcaagctg ttcaggtgcc gcccctactg tggagatgga tgaggagctg     2100

cattatgctt ccctcaactt tcatgggatg aatccttcca aggacacctc caccgaatac     2160

tcagaggtca ggacccag                                                   2178


<210>  107
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 2D protein

<400>  107

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly 
145                 150                 155                 160 


Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser Trp 
                165                 170                 175     


Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala Ala 
            180                 185                 190         


Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile Ile 
        195                 200                 205             


Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu Asn Val 
225                 230                 235                 240 


Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly Asp Gly 
                245                 250                 255     


Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Pro Arg Asp Val 
            260                 265                 270         


Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser 
        275                 280                 285             


Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln 
    290                 295                 300                 


Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu 
305                 310                 315                 320 


Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp 
                325                 330                 335     


Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu 
            340                 345                 350         


Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp 
        355                 360                 365             


Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala 
    370                 375                 380                 


Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser 
385                 390                 395                 400 


Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln 
                405                 410                 415     


His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly 
            420                 425                 430         


Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Gly 
        435                 440                 445             


Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys 
    450                 455                 460                 


Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr 
465                 470                 475                 480 


Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro 
                485                 490                 495     


Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser 
            500                 505                 510         


Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr 
        515                 520                 525             


Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr 
    530                 535                 540                 


Glu Tyr Ser Glu Val Arg Thr Gln 
545                 550         


<210>  108
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 2D nucleotides

<400>  108
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacagacttg acccacaggc ccaaaatcct catccctggc      480

actctagaac ccggccactc caaaaacctg acctgctctg tgtcctgggc ctgtgagcag      540

ggaacacccc cgatcttctc ctggttgtca gctgccccca cctccctggg ccccaggact      600

actcactcct cggtgctcat aatcacccca cggccccagg accacggcac caacctgacc      660

tgtcaggtga agttcgctgg agctggtgtg actacggaga gaaccatcca gctgaacgtc      720

acctatgttc cacagaaccc aacaactggt atctttccag gagatggctc agggaaacaa      780

gagaccagag caggagtggt tcatccccga gacgtgaggg tccggaaaat caagcccctt      840

tccgagattc actctggaaa ctcggtcagc ctccaatgtg acttctcaag cagccacccc      900

aaagaagtcc agttcttctg ggagaaaaat ggcaggcttc tggggaaaga aagccagctg      960

aattttgact ccatctcccc agaagatgct gggagttaca gctgctgggt gaacaactcc     1020

ataggacaga cagcgtccaa ggcctggaca cttgaagtgc tgtatgcacc caggaggctg     1080

cgtgtgtcca tgagcccagg ggaccaagtg atggagggga agagtgcaac cctgacctgt     1140

gagagcgacg ccaaccctcc cgtctcccac tacacctggt ttgactggaa taaccaaagc     1200

ctcccctacc acagccagaa gctgagattg gagccggtga aggtccagca ctcgggtgcc     1260

tactggtgcc aggggaccaa cagtgtgggc aagggccgtt cgcctctcag caccctcacc     1320

gtctactata gcccggagac cggggccatt ggaggagctg gtgttacagc cctgctcgct     1380

ctttgtctct gcctcatctt cttcatagtg aagacccaca ggaggaaagc agccaggaca     1440

gcagtgggca ggaatgacac ccaccctacc acagggtcag cctccccgaa acaccagaag     1500

aagtccaagt tacatggccc cactgaaacc tcaagctgtt caggtgccgc ccctactgtg     1560

gagatggatg aggagctgca ttatgcttcc ctcaactttc atgggatgaa tccttccaag     1620

gacacctcca ccgaatactc agaggtcagg acccag                               1656


<210>  109
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 V-set construct (exon 3 and 4 deleted) protein

<400>  109

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro 
145                 150                 155                 160 


Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Gly 
                165                 170                 175     


Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys 
            180                 185                 190         


Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr 
        195                 200                 205             


Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro 
    210                 215                 220                 


Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser 
225                 230                 235                 240 


Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr 
                245                 250                 255     


Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr 
            260                 265                 270         


Glu Tyr Ser Glu Val Arg Thr Gln 
        275                 280 


<210>  110
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 V-set construct (exon 3 and 4 deleted) nucleotides

<400>  110
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacatatgtt ccacagaacc caacaactgg tatctttcca      480

ggagatggct cagggaaaca agagaccaga gcaggagtgg ttcatggggc cattggagga      540

gctggtgtta cagccctgct cgctctttgt ctctgcctca tcttcttcat agtgaagacc      600

cacaggagga aagcagccag gacagcagtg ggcaggaatg acacccaccc taccacaggg      660

tcagcctccc cgaaacacca gaagaagtcc aagttacatg gccccactga aacctcaagc      720

tgttcaggtg ccgcccctac tgtggagatg gatgaggagc tgcattatgc ttccctcaac      780

tttcatggga tgaatccttc caaggacacc tccaccgaat actcagaggt caggacccag      840


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 signal peptide

<400>  111

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met 
    


<210>  112
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 signal peptide coding sequence

<400>  112
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat g                51


<210>  113
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His tag coding sequence

<400>  113
catcatcacc accatcac                                                     18


<210>  114
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain

<400>  114

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  115
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain coding sequence

<400>  115
gatccaaatt tctggctgca agtgcaggag tcagtgacgg tacaggaggg tttgtgcgtc       60

ctcgtgccct gcactttctt ccatcccata ccctactacg acaagaactc cccagttcat      120

ggttactggt tccgggaagg agccattata tccagggact ctccagtggc cacaaacaag      180

ctagatcaag aagtacagga ggagactcag ggcagattcc gcctccttgg ggatcccagt      240

aggaacaact gctccctgag catcgtagac gccaggagga gggataatgg ttcatacttc      300

tttcggatgg agagaggaag taccaaatac agttacaaat ctccccagct ctctgtgcat      360

gtgacagact tgacccacag gcccaaaatc ctcatccctg gcactctaga acccggccac      420

tccaaaaacc tgacctgctc tgtgtcctgg gcctgtgagc agggaacacc cccgatcttc      480

tcctggttgt cagctgcccc cacctccctg ggccccagga ctactcactc ctcggtgctc      540

ataatcaccc cacggcccca ggaccacggc accaacctga cctgtcaggt gaagttcgct      600

ggagctggtg tgactacgga gagaaccatc cagctgaacg tcacctatgt tccacagaac      660

ccaacaactg gtatctttcc aggagatggc tcagggaaac aagagaccag agcaggagtg      720

gttcat                                                                 726


<210>  116
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain lacking CD33 amino acids 140-232

<400>  116

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Tyr Val Pro Gln Asn Pro 
        115                 120                 125             


Thr Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg 
    130                 135                 140                 


Ala Gly Val Val His 
145                 


<210>  117
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain lacking CD33 amino acids 140-232 coding
       sequence

<400>  117
gatccaaatt tctggctgca agtgcaggag tcagtgacgg tacaggaggg tttgtgcgtc       60

ctcgtgccct gcactttctt ccatcccata ccctactacg acaagaactc cccagttcat      120

ggttactggt tccgggaagg agccattata tccagggact ctccagtggc cacaaacaag      180

ctagatcaag aagtacagga ggagactcag ggcagattcc gcctccttgg ggatcccagt      240

aggaacaact gctccctgag catcgtagac gccaggagga gggataatgg ttcatacttc      300

tttcggatgg agagaggaag taccaaatac agttacaaat ctccccagct ctctgtgcat      360

gtgacatatg ttccacagaa cccaacaact ggtatctttc caggagatgg ctcagggaaa      420

caagagacca gagcaggagt ggttcat                                          447


<210>  118
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 transmembrane domain

<400>  118

Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Cys Leu Ile Phe Phe Ile Val 
            20              


<210>  119
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 transmembrane domain coding sequence

<400>  119
ggggccattg gaggagctgg tgttacagcc ctgctcgctc tttgtctctg cctcatcttc       60

ttcatagtg                                                               69


<210>  120
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 intracellular domain

<400>  120

Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp 
1               5                   10                  15      


Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser 
            20                  25                  30          


Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro 
        35                  40                  45              


Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His 
    50                  55                  60                  


Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg 
65                  70                  75                  80  


Thr Gln 
        


<210>  121
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 intracellular domain coding sequence

<400>  121
aagacccaca ggaggaaagc agccaggaca gcagtgggca ggaatgacac ccaccctacc       60

acagggtcag cctccccgaa acaccagaag aagtccaagt tacatggccc cactgaaacc      120

tcaagctgtt caggtgccgc ccctactgtg gagatggatg aggagctgca ttatgcttcc      180

ctcaactttc atgggatgaa tccttccaag gacacctcca ccgaatactc agaggtcagg      240

acccag                                                                 246


<210>  122
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 3, Ig-like C2-type 4, Ig-like C2-type 
       5, Ig-like C2-type 6

<400>  122

Pro Glu Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly 
1               5                   10                  15      


Ser Gln Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr 
            20                  25                  30          


Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu 
        35                  40                  45              


Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr 
    50                  55                  60                  


Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile 
                85                  90                  95      


Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys 
            100                 105                 110         


Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro 
        115                 120                 125             


His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn 
    130                 135                 140                 


Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp 
145                 150                 155                 160 


Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg 
                165                 170                 175     


Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly 
            180                 185                 190         


Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu 
        195                 200                 205             


Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser 
    210                 215                 220                 


Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser 
225                 230                 235                 240 


Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr 
                245                 250                 255     


Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro 
            260                 265                 270         


Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser 
        275                 280                 285             


Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn 
    290                 295                 300                 


Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys 
305                 310                 315                 320 


Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly 
                325                 330                 335     


Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu 
            340                 345                 350         


Thr 
    


<210>  123
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 3, Ig-like C2-type 4, Ig-like C2-type 
       5, Ig-like C2-type 6 coding sequence

<400>  123
ccggaacctt ccacggttca gatcctccac tcaccggctg tggagggaag tcaagtcgag       60

tttctttgca tgtcactggc caatcctctt ccaacaaatt acacgtggta ccacaatggg      120

aaagaaatgc agggaaggac agaggagaaa gtccacatcc caaagatcct cccttggcac      180

gctgggactt attcctgtgt ggcagaaaac attcttggta ctggacagag gggccctgga      240

gctgagctgg atgtccagta tcctcccaag aaggtgacca cagtgattca aaaccccatg      300

ccgattcgag aaggagacac agtgaccctt tcctgtaact acaattccag taaccccagt      360

gttacccggt atgaatggaa accccatggc gcctgggagg agccatcgct tggggtgctg      420

aagatccaaa acgttggctg ggacaacaca accatcgcct gcgcagcttg taatagttgg      480

tgctcgtggg cctcccctgt cgccctgaat gtccagtatg ccccccgaga cgtgagggtc      540

cggaaaatca agcccctttc cgagattcac tctggaaact cggtcagcct ccaatgtgac      600

ttctcaagca gccaccccaa agaagtccag ttcttctggg agaaaaatgg caggcttctg      660

gggaaagaaa gccagctgaa ttttgactcc atctccccag aagatgctgg gagttacagc      720

tgctgggtga acaactccat aggacagaca gcgtccaagg cctggacact tgaagtgctg      780

tatgcaccca ggaggctgcg tgtgtccatg agcccagggg accaagtgat ggaggggaag      840

agtgcaaccc tgacctgtga gagcgacgcc aaccctcccg tctcccacta cacctggttt      900

gactggaata accaaagcct cccctaccac agccagaagc tgagattgga gccggtgaag      960

gtccagcact cgggtgccta ctggtgccag gggaccaaca gtgtgggcaa gggccgttcg     1020

cctctcagca ccctcaccgt ctactatagc ccggagacc                            1059


<210>  124
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 5, Ig-like C2-type 6

<400>  124

Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
1               5                   10                  15      


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
            20                  25                  30          


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
        35                  40                  45              


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
    50                  55                  60                  


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
65                  70                  75                  80  


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
                85                  90                  95      


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
            100                 105                 110         


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
        115                 120                 125             


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
    130                 135                 140                 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
145                 150                 155                 160 


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
                165                 170                 175     


Pro Glu Thr 
            


<210>  125
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 5, Ig-like C2-type 6 coding sequence

<400>  125
ccccgagacg tgagggtccg gaaaatcaag cccctttccg agattcactc tggaaactcg       60

gtcagcctcc aatgtgactt ctcaagcagc caccccaaag aagtccagtt cttctgggag      120

aaaaatggca ggcttctggg gaaagaaagc cagctgaatt ttgactccat ctccccagaa      180

gatgctggga gttacagctg ctgggtgaac aactccatag gacagacagc gtccaaggcc      240

tggacacttg aagtgctgta tgcacccagg aggctgcgtg tgtccatgag cccaggggac      300

caagtgatgg aggggaagag tgcaaccctg acctgtgaga gcgacgccaa ccctcccgtc      360

tcccactaca cctggtttga ctggaataac caaagcctcc cctaccacag ccagaagctg      420

agattggagc cggtgaaggt ccagcactcg ggtgcctact ggtgccaggg gaccaacagt      480

gtgggcaagg gccgttcgcc tctcagcacc ctcaccgtct actatagccc ggagacc         537


<210>  126
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7 VLVH scFv coding sequence

<400>  126
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgata ttcagatgac ccaaactacg agttccctgt ctgccagcct tggcgaccgg      120

gtcacaatta gttgcagggc ttctcaggat atcaactact atttgaactg gtaccagcag      180

aaacctgatg ggacggtcaa acttctcatc tactattcat ccagactgca cagtggcgta      240

ccgtctagat tctcaggaag cggcagtggt acggatttta gtcttaccat tagtaatctg      300

gaacaggagg acatcgccac gtatttttgc cagcaggatg acgcactgcc ctataccttc      360

ggcggaggca ctaagttgga gataaaagga ggcggaggat ctggcggagg gggctctgga      420

ggaggaggat ctcaagtaca acttcaacaa agtggagccg aactggtaaa acccggagcg      480

tctgtgaaga ttagttgcaa ggcatccggt tacgccttct caaattattg gatgaactgg      540

gtaaagcagc ggcccggaaa gggtctcgag tggattgggc aaatcaaccc aggggacggg      600

gatacgaact acaacggtaa gttcaaaggc aaggctacgt tgacggctga taagagctca      660

agcaccgctt acatgcagtt gtcttctttg acaagtgagg atagtgccgt ttacttctgc      720

gcccgagagg accgagatta ttttgattat tggggccagg gaacaactct caccgtcagc      780

tcc                                                                    783


<210>  127
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 VHVL scFv coding sequence

<400>  127
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcaactcca gcagtccggc gccgagctgg tcaggccagg tgcatccgta      120

actctgtcat gtaaggcgtc cggatacacc ttcacggact acgaaatgca ttggataaaa      180

caaactccag ttcatgggtt ggagtggatt ggctccatag acccggaaac gggagtaacg      240

gcgtataacc agaaattcac ggggaaagcg atagtaacgg cagacaagtc tagtagcact      300

gcctacatgg aacttagaag tctcacaagt gaagacagcg cggtatatta ttgcacctcc      360

gattatggat actttgacgt ttggggtacg ggcacgacag tgactgttag ttctggaggc      420

ggaggatctg gcggaggggg ctctggagga ggaggatctg atgttgtaat gacgcagtct      480

caaaagttta tgtcaacgtc tgttggtgat cgcgttagca ttacctgcaa agcatctcaa      540

agtgtaggat ctgatgtggc atggtaccag caacggcctg gacgctgtcc taaagcgctg      600

atttatcttg cttctaaccg gcatacgggg gtcccagaca ggtttactgg gtctggatct      660

ggaacggact ttacactgac catatcaaac gttcagtcag aggacctggc cgagtatttc      720

tgtcaacaat ataacatata cccctatacc ttcggtggag gaactaaatt ggagataaag      780


<210>  128
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 VLVH scFv coding sequence

<400>  128
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgatg ttgtaatgac gcagtctcaa aagtttatgt caacgtctgt tggtgatcgc      120

gttagcatta cctgcaaagc atctcaaagt gtaggatctg atgtggcatg gtaccagcaa      180

cggcctggac gctgtcctaa agcgctgatt tatcttgctt ctaaccggca tacgggggtc      240

ccagacaggt ttactgggtc tggatctgga acggacttta cactgaccat atcaaacgtt      300

cagtcagagg acctggccga gtatttctgt caacaatata acatataccc ctataccttc      360

ggtggaggaa ctaaattgga gataaaggga ggcggaggat ctggcggagg gggctctgga      420

ggaggaggat ctcaggtgca actccagcag tccggcgccg agctggtcag gccaggtgca      480

tccgtaactc tgtcatgtaa ggcgtccgga tacaccttca cggactacga aatgcattgg      540

ataaaacaaa ctccagttca tgggttggag tggattggct ccatagaccc ggaaacggga      600

gtaacggcgt ataaccagaa attcacgggg aaagcgatag taacggcaga caagtctagt      660

agcactgcct acatggaact tagaagtctc acaagtgaag acagcgcggt atattattgc      720

acctccgatt atggatactt tgacgtttgg ggtacgggca cgacagtgac tgttagttct      780


<210>  129
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 VHVL scFv coding sequence

<400>  129
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcaactcca gcagtccggc gccgagctgg tcaggccagg tgcatccgta      120

actctgtcat gtaaggcgtc cggatacacc ttcacggact acgaaatgca ttggataaaa      180

caaactccag ttcatgggtt ggagtggatt ggctccatag acccggaaac gggagtaacg      240

gcgtataacc agaaattcac ggggaaagcg atagtaacgg cagacaagtc tagtagcact      300

gcctacatgg aacttagaag tctcacaagt gaagacagcg cggtatatta ttgcacctcc      360

gattatggat actttaacgt ttggggtacg ggcacgacag tgactgttag ttctggaggc      420

ggaggatctg gcggaggggg ctctggagga ggaggatctg atgttgtaat gacgcagtct      480

caaaagttta tgtcaacgtc tgttggtgat cgcgttagca ttacctgcaa agcatctcaa      540

agtgtaggat ctgatgtggc atggtaccag caacggcctg gacgctgtcc taaagcgctg      600

atttatcttg cttctaaccg gcatacgggg gtcccagaca ggtttactgg gtctggatct      660

ggaacggact ttacactgac catatcaaac gttcagtcag aggacctggc cgagtatttc      720

tgtcaacaat ataacatata cccctatacc ttcggtggag gaactaaatt ggagataaag      780


<210>  130
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 VLVH scFv coding sequence

<400>  130
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgatg ttgtaatgac gcagtctcaa aagtttatgt caacgtctgt tggtgatcgc      120

gttagcatta cctgcaaagc atctcaaagt gtaggatctg atgtggcatg gtaccagcaa      180

cggcctggac gctgtcctaa agcgctgatt tatcttgctt ctaaccggca tacgggggtc      240

ccagacaggt ttactgggtc tggatctgga acggacttta cactgaccat atcaaacgtt      300

cagtcagagg acctggccga gtatttctgt caacaatata acatataccc ctataccttc      360

ggtggaggaa ctaaattgga gataaaggga ggcggaggat ctggcggagg gggctctgga      420

ggaggaggat ctcaggtgca actccagcag tccggcgccg agctggtcag gccaggtgca      480

tccgtaactc tgtcatgtaa ggcgtccgga tacaccttca cggactacga aatgcattgg      540

ataaaacaaa ctccagttca tgggttggag tggattggct ccatagaccc ggaaacggga      600

gtaacggcgt ataaccagaa attcacgggg aaagcgatag taacggcaga caagtctagt      660

agcactgcct acatggaact tagaagtctc acaagtgaag acagcgcggt atattattgc      720

acctccgatt atggatactt taacgtttgg ggtacgggca cgacagtgac tgttagttct      780


<210>  131
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9G2 VLVH scFv coding sequence

<400>  131
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgata tacaaatgac tcagacaacg agcagtttgt ccgcatctct tggcgatcga      120

gtaactatta gctgcaagac atcccaggac atatataatt atttgaattg gtatcagcag      180

aaaccggacg gaactgtcaa actcctcatt tattatacct ccaggcttca tagtggggtt      240

ccttcccgat ttagtggagg aggctcaggt acggactaca gcctgacgat ttccaacctt      300

gaacaagaag atatagctac atacttctgt cagcaaggtg acaccttgcc ctggacattc      360

ggtgggggta caaaactcga aataaaggga ggcggaggat ctggcggagg gggctctgga      420

ggaggaggat ctgaggtcaa gcttgtcgag tcagagggag gtttggtcca gccgggttct      480

tctatgaaac tctcctgcac agccagtggc tttacattta gtgattacta catgagttgg      540

gtgagacagg tgcctgagaa agggctggag tgggtagctt ccattaacta cgacggaggt      600

agcacctatt acttggactc cttgaaaagc agattcataa tttccaggga taatacgaaa      660

aacatacttt atcttcaaat gtcctctttg aagagcgagg acacagccac atactattgc      720

gccagggata gaggcgatgg tgattatttt gactattggg gacagggcac aacactcacg      780

gtcagcagc                                                              789


<210>  132
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variant 1 VHVL scFv coding sequence

<400>  132
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg ttcaacttaa agagagcggc cccggcctgg tcgcaccctc tcagtctctc      120

tccatcacat gcactgtgag cgggttttca ctcacaagct acaacattaa ctggataaga      180

caaccaccgg gaaaaggatt ggaatggttg ggtgtgatat ggaccggtgg agacacgaac      240

tataactccg cctttatgag taggcttagt atatccaaag acaattcaaa gagtcaactg      300

ttcctgaaga tgaatagcct ccagacggac gacacggcca tctactactg cgttcgggac      360

gggactggca ctggggacta ttttgactac tgggggcaag gtacgactct gacggtgtca      420

agcggaggcg gaggatctgg cggagggggc tctggaggag gaggatctga tattcagatg      480

acccaaacga cttcatcatt gagtgcctcc cttggggatc gagttacgat ttcatgcagg      540

gccagccaag atattttcaa ttacctgaat tggtatcagc agaagcctga cggtacagtc      600

aaacttttga tctattacgc cagtagattg cacagcggcg taccaagtcg atttagcggg      660

agcggaagtg gcacagacta ctcccttaca attcataacc tggaacagga ggacatagct      720

acctatttct gtcaacaagg ggacacgctg ccttacacgt ttggcggagg cactaaactt      780

gaaataaag                                                              789


<210>  133
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variant 2 VHVL scFv coding sequence

<400>  133
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg ttcaacttaa agagagcggc cccggcctgg tcgcaccctc tcagtctctc      120

tccatcacat gcactgtgag cgggttttca ctcacaagct acaacattaa ctggataaga      180

caaccaccgg gaaaaggatt ggaatggttg ggtgtgatat ggaccggtgg agacacgaac      240

tataactccg cctttatgag taggcttagt atatccaaag acaattcaaa gagtcaactg      300

ttcctgaaga tgaatagcct ccagacggac gacacggcca tctactactg cgttcgggac      360

gggactggca ctggggacca ttttgactac tgggggcaag gtacgactct gacggtgtca      420

agcggaggcg gaggatctgg cggagggggc tctggaggag gaggatctga tattcagatg      480

acccaaacga cttcatcatt gagtgcctcc cttggggatc gagttacgat ttcatgcagg      540

gccagccaag atattttcaa ttacctgaat tggtatcagc agaagcctga cggtacagtc      600

aaacttttga tctattacgc cagtagattg cacagcggcg taccaagtcg atttagcggg      660

agcggaagtg gcacagacta ctcccttaca attcataacc tggaacagga ggacatagct      720

acctatttct gtcaacaagg ggacacgctg ccttacacgt ttggcggagg cactaaactt      780

gaaataaag                                                              789


<210>  134
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide coding sequence

<400>  134
ctgctgctcg tgaccagcct gctgctgtgc gaactgcccc accctgcctt tctgctgatc       60

ccc                                                                     63


<210>  135
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G4Sx3 linker coding sequence

<400>  135
ggaggcggag gatctggcgg agggggctct ggaggaggag gatct                       45


<210>  136
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7 Variable Light Chain coding sequence

<400>  136
gatattcaga tgacccaaac tacgagttcc ctgtctgcca gccttggcga ccgggtcaca       60

attagttgca gggcttctca ggatatcaac tactatttga actggtacca gcagaaacct      120

gatgggacgg tcaaacttct catctactat tcatccagac tgcacagtgg cgtaccgtct      180

agattctcag gaagcggcag tggtacggat tttagtctta ccattagtaa tctggaacag      240

gaggacatcg ccacgtattt ttgccagcag gatgacgcac tgccctatac cttcggcgga      300

ggcactaagt tggagataaa a                                                321


<210>  137
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7 Variable Heavy Chain coding sequence

<400>  137
caagtacaac ttcaacaaag tggagccgaa ctggtaaaac ccggagcgtc tgtgaagatt       60

agttgcaagg catccggtta cgccttctca aattattgga tgaactgggt aaagcagcgg      120

cccggaaagg gtctcgagtg gattgggcaa atcaacccag gggacgggga tacgaactac      180

aacggtaagt tcaaaggcaa ggctacgttg acggctgata agagctcaag caccgcttac      240

atgcagttgt cttctttgac aagtgaggat agtgccgttt acttctgcgc ccgagaggac      300

cgagattatt ttgattattg gggccaggga acaactctca ccgtcagctc c               351


<210>  138
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 and variant 2 Variable Light Chain coding sequence

<400>  138
gatgttgtaa tgacgcagtc tcaaaagttt atgtcaacgt ctgttggtga tcgcgttagc       60

attacctgca aagcatctca aagtgtagga tctgatgtgg catggtacca gcaacggcct      120

ggacgctgtc ctaaagcgct gatttatctt gcttctaacc ggcatacggg ggtcccagac      180

aggtttactg ggtctggatc tggaacggac tttacactga ccatatcaaa cgttcagtca      240

gaggacctgg ccgagtattt ctgtcaacaa tataacatat acccctatac cttcggtgga      300

ggaactaaat tggagataaa g                                                321


<210>  139
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 Variable Heavy Chain coding sequence

<400>  139
caggtgcaac tccagcagtc cggcgccgag ctggtcaggc caggtgcatc cgtaactctg       60

tcatgtaagg cgtccggata caccttcacg gactacgaaa tgcattggat aaaacaaact      120

ccagttcatg ggttggagtg gattggctcc atagacccgg aaacgggagt aacggcgtat      180

aaccagaaat tcacggggaa agcgatagta acggcagaca agtctagtag cactgcctac      240

atggaactta gaagtctcac aagtgaagac agcgcggtat attattgcac ctccgattat      300

ggatactttg acgtttgggg tacgggcacg acagtgactg ttagttct                   348


<210>  140
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 Variable Heavy Chain coding sequence

<400>  140
caggtgcaac tccagcagtc cggcgccgag ctggtcaggc caggtgcatc cgtaactctg       60

tcatgtaagg cgtccggata caccttcacg gactacgaaa tgcattggat aaaacaaact      120

ccagttcatg ggttggagtg gattggctcc atagacccgg aaacgggagt aacggcgtat      180

aaccagaaat tcacggggaa agcgatagta acggcagaca agtctagtag cactgcctac      240

atggaactta gaagtctcac aagtgaagac agcgcggtat attattgcac ctccgattat      300

ggatacttta acgtttgggg tacgggcacg acagtgactg ttagttct                   348


<210>  141
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9G2 Variable Light Chain coding sequence

<400>  141
gatatacaaa tgactcagac aacgagcagt ttgtccgcat ctcttggcga tcgagtaact       60

attagctgca agacatccca ggacatatat aattatttga attggtatca gcagaaaccg      120

gacggaactg tcaaactcct catttattat acctccaggc ttcatagtgg ggttccttcc      180

cgatttagtg gaggaggctc aggtacggac tacagcctga cgatttccaa ccttgaacaa      240

gaagatatag ctacatactt ctgtcagcaa ggtgacacct tgccctggac attcggtggg      300

ggtacaaaac tcgaaataaa g                                                321


<210>  142
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9G2 Variable Heavy Chain coding sequence

<400>  142
gaggtcaagc ttgtcgagtc agagggaggt ttggtccagc cgggttcttc tatgaaactc       60

tcctgcacag ccagtggctt tacatttagt gattactaca tgagttgggt gagacaggtg      120

cctgagaaag ggctggagtg ggtagcttcc attaactacg acggaggtag cacctattac      180

ttggactcct tgaaaagcag attcataatt tccagggata atacgaaaaa catactttat      240

cttcaaatgt cctctttgaa gagcgaggac acagccacat actattgcgc cagggataga      300

ggcgatggtg attattttga ctattgggga cagggcacaa cactcacggt cagcagc         357


<210>  143
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variant 1 and variant 2 Variable Light Chain coding sequence

<400>  143
gatattcaga tgacccaaac gacttcatca ttgagtgcct cccttgggga tcgagttacg       60

atttcatgca gggccagcca agatattttc aattacctga attggtatca gcagaagcct      120

gacggtacag tcaaactttt gatctattac gccagtagat tgcacagcgg cgtaccaagt      180

cgatttagcg ggagcggaag tggcacagac tactccctta caattcataa cctggaacag      240

gaggacatag ctacctattt ctgtcaacaa ggggacacgc tgccttacac gtttggcgga      300

ggcactaaac ttgaaataaa g                                                321


<210>  144
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variant 1 Variable Heavy Chain coding sequence

<400>  144
caggttcaac ttaaagagag cggccccggc ctggtcgcac cctctcagtc tctctccatc       60

acatgcactg tgagcgggtt ttcactcaca agctacaaca ttaactggat aagacaacca      120

ccgggaaaag gattggaatg gttgggtgtg atatggaccg gtggagacac gaactataac      180

tccgccttta tgagtaggct tagtatatcc aaagacaatt caaagagtca actgttcctg      240

aagatgaata gcctccagac ggacgacacg gccatctact actgcgttcg ggacgggact      300

ggcactgggg actattttga ctactggggg caaggtacga ctctgacggt gtcaagc         357


<210>  145
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variant 2 Variable Heavy Chain coding sequence

<400>  145
caggttcaac ttaaagagag cggccccggc ctggtcgcac cctctcagtc tctctccatc       60

acatgcactg tgagcgggtt ttcactcaca agctacaaca ttaactggat aagacaacca      120

ccgggaaaag gattggaatg gttgggtgtg atatggaccg gtggagacac gaactataac      180

tccgccttta tgagtaggct tagtatatcc aaagacaatt caaagagtca actgttcctg      240

aagatgaata gcctccagac ggacgacacg gccatctact actgcgttcg ggacgggact      300

ggcactgggg accattttga ctactggggg caaggtacga ctctgacggt gtcaagc         357


<210>  146
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 8F5

<400>  146

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 8F5

<400>  147

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 8F5

<400>  148

Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5

<400>  149

Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Tyr 
1               5                   10      


<210>  150
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  150

Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr Pro Asp Thr Val Glu 
1               5                   10                  15      


Gly 
    


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 8F5

<400>  151

Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
1               5                   10  


<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 12B12

<400>  152

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 12B12 and/or 11D5

<400>  153

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 12B12 and/or 11D5

<400>  154

Ala Gln Asn Leu Glu Leu Pro Pro Thr 
1               5                   


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  155

Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  156
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  156

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
1               5                   10              


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 12B12

<400>  157

Tyr Asp Gly Tyr His Phe Ile 
1               5           


<210>  158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D11

<400>  158

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 11D11, 6H9, and/or 9G2

<400>  159

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 11D11

<400>  160

Gln Gln Gly Ser Thr Leu Pro Pro Thr 
1               5                   


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D11

<400>  161

Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Glu 
1               5                   10      


<210>  162
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  162

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr 
1               5                   10              


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D11

<400>  163

Asp Thr Gly Pro Met Asp Tyr 
1               5           


<210>  164
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7E7

<400>  164

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7E7

<400>  165

Val Ser Lys Leu Asp Ser Gly 
1               5           


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 7E7

<400>  166

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  167

Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly Ile Gly 
1               5                   10          


<210>  168
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  168

His Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro Asp Leu Lys Ser 
1               5                   10                  15      


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7E7

<400>  169

Asp Gly Gly Tyr Ser Leu Phe Ala Tyr 
1               5                   


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D5

<400>  170

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  171

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  172
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  172

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
1               5                   10              


<210>  173
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D5

<400>  173

Tyr Asp Gly Tyr His Phe Asp Tyr 
1               5               


<210>  174
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 13E11

<400>  174

Lys Ala Ser His Gly Val Glu Tyr Ala Gly Ala His Tyr Met Asn 
1               5                   10                  15  


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 13E11

<400>  175

Ala Ala Ser Asn Leu Gly Ser 
1               5           


<210>  176
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 13E11

<400>  176

Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  177

Gly Tyr Thr Phe Thr Asp Tyr Thr Leu His 
1               5                   10  


<210>  178
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  178

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu 
1               5                   10              


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 13E11

<400>  179

His Lys Phe Gly Phe Asp Tyr 
1               5           


<210>  180
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 5D12

<400>  180

Tyr Tyr Ala Thr Thr Leu Ala Asp 
1               5               


<210>  181
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 5D12

<400>  181

Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10              


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  182

Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp 
1               5                   10  


<210>  183
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 5D12

<400>  183

Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr 
1               5                   10                  


<210>  184
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 3A5v1 and/or 3A5v2

<400>  184

Lys Ala Ser Gln Ser Val Gly Ser Asp Val Ala 
1               5                   10      


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 3A5v1 and/or 3A5v2

<400>  185

Tyr Leu Ala Ser Asn Arg His Thr 
1               5               


<210>  186
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 3A5v1 and/or 3A5v2

<400>  186

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met His 
1               5                   10              


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  187

Ser Ile Asp Pro Glu Thr Gly Val Thr Ala 
1               5                   10  


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v1

<400>  188

Thr Ser Asp Tyr Gly Tyr Phe Asp Val 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v2

<400>  189

Thr Ser Asp Tyr Gly Tyr Phe Asn Val 
1               5                   


<210>  190
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7D5v1 and/or 7D5v2

<400>  190

Arg Ala Ser Gln Asp Ile Phe Asn Tyr Leu Asn 
1               5                   10      


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7D5v1 and/or 7D5v2

<400>  191

Tyr Tyr Ala Ser Arg Leu His Ser 
1               5               


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 7D5v1 and/or 7D5v2

<400>  192

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  193
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  193

Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Asn Ile Asn 
1               5                   10              


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  194

Val Ile Trp Thr Gly Gly Asp Thr Asn 
1               5                   


<210>  195
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v1

<400>  195

Val Arg Asp Gly Thr Gly Thr Gly Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  196
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v2

<400>  196

Val Arg Asp Gly Thr Gly Thr Gly Asp His Phe Asp Tyr 
1               5                   10              


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 8F5

<400>  197

Tyr Trp Ala Ser Thr Arg Glu Ser 
1               5               


<210>  198
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5

<400>  198

Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Tyr 
1               5                   10              


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  199

Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr 
1               5                   10  


<210>  200
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 8F5

<400>  200

Thr Lys Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 12B12 and/or 11D5

<400>  201

Tyr Gln Met Ser Asn Leu Ala Ser 
1               5               


<210>  202
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  202

Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10              


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  203

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser 
1               5                   10  


<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 12B12

<400>  204

Glu Ile Tyr Asp Gly Tyr His Phe Ile Tyr 
1               5                   10  


<210>  205
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D11

<400>  205

Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Glu 
1               5                   10              


<210>  206
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  206

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu 
1               5                   10          


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D11

<400>  207

Thr Arg Asp Thr Gly Pro Met Asp Tyr 
1               5                   


<210>  208
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7E7

<400>  208

His Leu Val Ser Lys Leu Asp Ser 
1               5               


<210>  209
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  209

Ser Phe Ser Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly Ile Gly 
1               5                   10                  15  


<210>  210
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  210

His Ile Val Trp Trp Asp Asp Asn Lys Tyr 
1               5                   10  


<210>  211
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7E7

<400>  211

Ala Arg Asp Gly Gly Tyr Ser Leu Phe Ala Tyr 
1               5                   10      


<210>  212
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  212

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10              


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  213

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser 
1               5                   10  


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D5

<400>  214

Lys Ile Tyr Asp Gly Tyr His Phe Asp Tyr 
1               5                   10  


<210>  215
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 13E11

<400>  215

Tyr Ala Ala Ser Asn Leu Gly Ser 
1               5               


<210>  216
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  216

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Thr Leu His 
1               5                   10              


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  217

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn 
1               5                   10  


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 13E11

<400>  218

Ala Arg His Lys Phe Gly Phe Asp Tyr 
1               5                   


<210>  219
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H7

<400>  219

Gln Asp Ile Asn Tyr Tyr 
1               5       


<210>  220
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33/CD3 bispecific molecule

<400>  220

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu His His His His His His 
            500                 505                 510     


<210>  221
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 and/or 5D12

<400>  221

Gly Tyr Ala Phe Ser Asn Tyr Trp 
1               5               


<210>  222
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  222

Ile Asn Pro Gly Asp Gly Asp Thr 
1               5               


<210>  223
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 6H9

<400>  223

Gln Asp Ile Asn Ile Tyr 
1               5       


<210>  224
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B12 variable heavy chain

<400>  224

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Ser Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ile Tyr Asp Gly Tyr His Phe Ile Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  225
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  225

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  226
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  226

Ile Ser Gly Asp Gly Gly Asn Thr 
1               5               


<210>  227
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 9G2

<400>  227

Gln Asp Ile Tyr Asn Tyr 
1               5       


<210>  228
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  228

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  229
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  229

Ile Asn Tyr Asp Gly Gly Ser Thr 
1               5               


<210>  230
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D5

<400>  230

Gln Asn Val Gly Thr Asn 
1               5       


<210>  231
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D11 variable light chain

<400>  231

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  232
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5

<400>  232

Gly Tyr Thr Phe Thr Asp Tyr Asp 
1               5               


<210>  233
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  233

Ile Asp Pro Glu Thr Gly Gly Thr 
1               5               


<210>  234
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 5D12

<400>  234

Gln Asp Ile Lys Ser Tyr 
1               5       


<210>  235
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D11 variable heavy chain

<400>  235

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Lys Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Thr Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  236
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  236

Ile Tyr Pro Gly Asn Phe Asn Thr 
1               5               


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 3A5v1 and/or 3A5v2

<400>  237

Gln Ser Val Gly Ser Asp 
1               5       


<210>  238
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E7 variable light chain

<400>  238

Asp Val Val Met Thr Gln Thr Pro Leu Ile Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile His Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  239
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 3A5v1 and/or 3A5v2

<400>  239

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  240
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  240

Ile Asp Pro Glu Thr Gly Val Thr 
1               5               


<210>  241
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7D5v1 and/or 7D5v2

<400>  241

Gln Asp Ile Phe Asn Tyr 
1               5       


<210>  242
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E7 variable heavy chain

<400>  242

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Ser Tyr 
            20                  25                  30          


Gly Met Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Val Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro 
    50                  55                  60                  


Asp Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Val Phe Leu Lys Ile Ala Asn Val Asp Thr Thr Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Gly Gly Tyr Ser Leu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Val 
        115                 120 


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  243

Gly Phe Ser Leu Thr Ser Tyr Asn 
1               5               


<210>  244
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  244

Ile Trp Thr Gly Gly Asp Thr 
1               5           


<210>  245
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 8F5

<400>  245

Gln Ser Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe 
1               5                   10          


<210>  246
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D5 variable light chain

<400>  246

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Asn Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  247
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5 and/or 11D11

<400>  247

Gly Phe Thr Phe Ser Asp Phe Tyr 
1               5               


<210>  248
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  248

Ile Ser Asn Ala Gly Val Thr Thr 
1               5               


<210>  249
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 12B12

<400>  249

Gln Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  250
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D5 variable heavy chain

<400>  250

Glu Val Gln Phe Gln Gln Ser Glu Thr Val Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Ile Tyr Asp Gly Tyr His Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  251
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  251

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  252
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  252

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  253
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D11

<400>  253

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  254
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  254

Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr 
1               5                   10  


<210>  255
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7E7

<400>  255

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  256
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E11 variable light chain

<400>  256

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser His Gly Val Glu Tyr Ala 
            20                  25                  30          


Gly Ala His Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gly Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  257
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  257

Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly 
1               5                   10  


<210>  258
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  258

Ile Val Trp Trp Asp Asp Asn Lys 
1               5               


<210>  259
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D5

<400>  259

Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  260
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  260

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  261
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  261

Ile Tyr Cys Gly Asn Ser Asp Thr 
1               5               


<210>  262
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 13E11

<400>  262

His Gly Val Glu Tyr Ala Gly Ala His Tyr 
1               5                   10  


<210>  263
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E11 variable heavy chain

<400>  263

Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Leu His Trp Leu Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Lys Phe Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  264
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  264

Gly Tyr Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  265
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  265

Phe Tyr Pro Thr Ser Gly Ser Ile 
1               5               


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H7

<400>  266

Tyr Ser Ser Arg Leu His Ser 
1               5           


<210>  267
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 and/or 5D12

<400>  267

Asn Tyr Trp Met Asn 
1               5   


<210>  268
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  268

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  269
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H7

<400>  269

Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5               


<210>  270
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  270

Ser Tyr Thr Met Ser 
1               5   


<210>  271
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  271

Thr Ile Ser Gly Asp Gly Gly Asn Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  272
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 6H9

<400>  272

Gln Gly Thr Gly Thr Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  273
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  273

Asp Tyr Tyr Met Ser 
1               5   


<210>  274
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  274

Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  275
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 9G2

<400>  275

Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  276
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2D5

<400>  276

Ser Ala Ser Asp Arg Tyr Ser 
1               5           


<210>  277
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5

<400>  277

Asp Tyr Asp Met His 
1               5   


<210>  278
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  278

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  279
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D5

<400>  279

Asp Tyr Asp Tyr Phe Gly Val 
1               5           


<210>  280
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 3A5v1 and/or 3A5v2

<400>  280

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  281
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 3A5v1 and/or 3A5v2

<400>  281

Asp Tyr Glu Met His 
1               5   


<210>  282
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  282

Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  283
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v1

<400>  283

Asp Tyr Gly Tyr Phe Asp Val 
1               5           


<210>  284
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v2

<400>  284

Asp Tyr Gly Tyr Phe Asn Val 
1               5           


<210>  285
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7D5v1 and/or 7D5v2

<400>  285

Tyr Ala Ser Arg Leu His Ser 
1               5           


<210>  286
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  286

Ser Tyr Asn Ile Asn 
1               5   


<210>  287
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  287

Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Phe Met Ser 
1               5                   10                  15      


<210>  288
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v1

<400>  288

Asp Gly Thr Gly Thr Gly Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  289
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v2

<400>  289

Asp Gly Thr Gly Thr Gly Asp His Phe Asp Tyr 
1               5                   10      


<210>  290
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5

<400>  290

Asp Phe Tyr Met Tyr 
1               5   


<210>  291
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  291

Thr Tyr Trp Met His 
1               5   


<210>  292
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  292

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  293
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 12B12

<400>  293

Tyr Asp Gly Tyr His Phe Ile Tyr 
1               5               


<210>  294
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D11

<400>  294

Asp Phe Tyr Met Glu 
1               5   


<210>  295
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  295

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Lys Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  296
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7E7

<400>  296

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  297

Ser Tyr Gly Met Gly Ile Gly 
1               5           


<210>  298
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  298

His Ile Val Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro Asp Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  299
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  299

Ser Tyr Trp Met His 
1               5   


<210>  300
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  300

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  301
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  301

Asp Tyr Thr Leu His 
1               5   


<210>  302
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  302

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  303
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 and/or 5D12

<400>  303

Gly Tyr Ala Phe Ser Asn Tyr 
1               5           


<210>  304
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  304

Asn Pro Gly Asp Gly Asp 
1               5       


<210>  305
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  305

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  306
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  306

Ser Gly Asp Gly Gly Asn 
1               5       


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  307

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  308
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  308

Asn Tyr Asp Gly Gly Ser 
1               5       


<210>  309
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5, 3A5v1, 3A5v2, and/or 13E11

<400>  309

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  310
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  310

Asp Pro Glu Thr Gly Gly 
1               5       


<210>  311
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  311

Tyr Pro Gly Asn Phe Asn 
1               5       


<210>  312
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  312

Asp Pro Glu Thr Gly Val 
1               5       


<210>  313
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  313

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  314
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  314

Trp Thr Gly Gly Asp 
1               5   


<210>  315
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5 and/or 11D11

<400>  315

Gly Phe Thr Phe Ser Asp Phe 
1               5           


<210>  316
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  316

Ser Asn Ala Gly Val Thr 
1               5       


<210>  317
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  317

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  318
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  318

Tyr Pro Gly Asn Ser Asp 
1               5       


<210>  319
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  319

Arg Asn Lys Ala Asn Asp Tyr Thr 
1               5               


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  320

Gly Phe Ser Leu Asn Ser Tyr Gly Met 
1               5                   


<210>  321
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  321

Val Trp Trp Asp Asp Asn 
1               5       


<210>  322
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  322

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  323
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  323

Tyr Cys Gly Asn Ser Asp 
1               5       


<210>  324
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  324

Tyr Pro Thr Ser Gly Ser 
1               5       


<210>  325
<211>  3297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D12-LvHv-intDS-41bb-3z-T-CD19t Top Strand

<400>  325
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgatataaag atgactcagt cacccagcag tatatacgct      660

agtctgggag aaagggtcac gataaattgt aaggcttcac aagacataaa aagttatctt      720

tcatggtatc aacagaaacc ctggaaaagc cccaagaccc ttatctacta cgctacgact      780

cttgcagatg gtgtaccaag tcggttttcc gggagcggct ccgggcaaga ctattctttg      840

acaatttcct ctttggagtc cgatgatacc gcaacctact actgcctgca tcacggtgag      900

tcaccatgga catttggcga agggacaaag cttgaaataa agggaggcgg aggatctggc      960

ggagggggct ctggaggagg aggatctcaa gttcagttgc aacaatcagg tgctgaggtg     1020

gtaaagccag gtgccagtgt caaaatatct tgccgggcgt ctggttatgc gttctccaac     1080

tattggatga actgggtaaa acaacgccca ggtaagggac tcgagtggat aggacaaata     1140

tacccaggca acttcaacac agactacaat ggtcaattca agggaaaggc tactcttaca     1200

gtcgataaat cttcaaacac ggcttacatg cagttgtcct ccttgacctc cgaggattca     1260

gcagtctatt tctgtgcccg attctttgat tttggcgctt attttacgtt ggattattgg     1320

ggccaaggga catctgtcac agtttcctcc gagtctaagt acggaccgcc ctgcccccct     1380

tgccctggcc agcctagaga accccaggtg tacaccctgc ctcccagcca ggaagagatg     1440

accaagaacc aggtgtccct gacctgcctg gtcaaaggct tctaccccag cgatatcgcc     1500

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg     1560

gacagcgacg gcagcttctt cctgtactcc cggctgaccg tggacaagag ccggtggcag     1620

gaaggcaacg tcttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1680

aagtccctga gcctgagcct gggcaagatg ttctgggtgc tggtggtggt cggaggcgtg     1740

ctggcctgct acagcctgct ggtcaccgtg gccttcatca tcttttgggt gaaacggggc     1800

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1860

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgcgg     1920

gtgaagttca gcagaagcgc cgacgcccct gcctaccagc agggccagaa tcagctgtac     1980

aacgagctga acctgggcag aagggaagag tacgacgtcc tggataagcg gagaggccgg     2040

gaccctgaga tgggcggcaa gcctcggcgg aagaaccccc aggaaggcct gtataacgaa     2100

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggagg     2160

cggggcaagg gccacgacgg cctgtatcag ggcctgtcca ccgccaccaa ggatacctac     2220

gacgccctgc acatgcaggc cctgccccca aggctcgagg gcggcggaga gggcagagga     2280

agtcttctaa catgcggtga cgtggaggag aatccaggcc ctaggatgcc acctccaaga     2340

ctcctcttct tcctcctctt cctgacacca atggaagtca ggcctgagga acctctagtg     2400

gtgaaggtgg aagagggaga taacgctgtg ttacagtgcc tcaagggaac ctcagatgga     2460

cccactcagc agctgacctg gtctcgggag tctccgctta aacccttcct gaaactcagc     2520

cttggactgc caggtctggg aatccacatg aggccactgg ctatctggct gttcatcttc     2580

aacgtctctc aacagatggg aggcttctac ctgtgtcagc ctggaccacc ttctgagaag     2640

gcatggcagc ctggttggac agtcaatgtg gagggttctg gtgagctgtt ccggtggaat     2700

gtttcggacc taggtggact gggatgtggt ctgaagaaca ggtcctcaga gggacctagc     2760

tctccttccg ggaagctcat gagccccaag ctgtatgtgt gggccaaaga ccgccctgag     2820

atctgggagg gagagcctcc gtgtgtccca ccgagggaca gcctgaacca gagcctcagc     2880

caggacctca ccatggcccc tggctccaca ctctggctgt cctgtggggt accccctgac     2940

tctgtgtcca ggggccccct ctcctggacc catgtgcacc ccaaggggcc taagtcattg     3000

ctgagcctag agctgaagga cgatcgccct gccagagata tgtgggtaat ggagacgggt     3060

ctgttgttgc cccgggccac agctcaagac gctggaaagt attattgtca ccgtggcaac     3120

ctgaccatgt cattccacct ggagatcact gctcggccag tactatggca ctggctgctg     3180

aggactggtg gctggaaggt ctcagctgtg actttggctt atctgatctt ctgcctgtgt     3240

tcccttgtgg gcattcttca tcttcaaaga gccctggtcc tgaggaggaa aagatga        3297


<210>  326
<211>  3282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5v1-HvLv-intDS-41bb-3z-T-CD19t Top Strand

<400>  326
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaggtgcaa ctccagcagt ccggcgccga gctggtcagg      660

ccaggtgcat ccgtaactct gtcatgtaag gcgtccggat acaccttcac ggactacgaa      720

atgcattgga taaaacaaac tccagttcat gggttggagt ggattggctc catagacccg      780

gaaacgggag taacggcgta taaccagaaa ttcacgggga aagcgatagt aacggcagac      840

aagtctagta gcactgccta catggaactt agaagtctca caagtgaaga cagcgcggta      900

tattattgca cctccgatta tggatacttt gacgtttggg gtacgggcac gacagtgact      960

gttagttctg gaggcggagg atctggcgga gggggctctg gaggaggagg atctgatgtt     1020

gtaatgacgc agtctcaaaa gtttatgtca acgtctgttg gtgatcgcgt tagcattacc     1080

tgcaaagcat ctcaaagtgt aggatctgat gtggcatggt accagcaacg gcctggacgc     1140

tgtcctaaag cgctgattta tcttgcttct aaccggcata cgggggtccc agacaggttt     1200

actgggtctg gatctggaac ggactttaca ctgaccatat caaacgttca gtcagaggac     1260

ctggccgagt atttctgtca acaatataac atatacccct ataccttcgg tggaggaact     1320

aaattggaga taaaggagtc taagtacgga ccgccctgcc ccccttgccc tggccagcct     1380

agagaacccc aggtgtacac cctgcctccc agccaggaag agatgaccaa gaaccaggtg     1440

tccctgacct gcctggtcaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1500

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggcagc     1560

ttcttcctgt actcccggct gaccgtggac aagagccggt ggcaggaagg caacgtcttc     1620

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1680

agcctgggca agatgttctg ggtgctggtg gtggtcggag gcgtgctggc ctgctacagc     1740

ctgctggtca ccgtggcctt catcatcttt tgggtgaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcgggtgaa gttcagcaga     1920

agcgccgacg cccctgccta ccagcagggc cagaatcagc tgtacaacga gctgaacctg     1980

ggcagaaggg aagagtacga cgtcctggat aagcggagag gccgggaccc tgagatgggc     2040

ggcaagcctc ggcggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2100

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgggg caagggccac     2160

gacggcctgt atcagggcct gtccaccgcc accaaggata cctacgacgc cctgcacatg     2220

caggccctgc ccccaaggct cgagggcggc ggagagggca gaggaagtct tctaacatgc     2280

ggtgacgtgg aggagaatcc aggccctagg atgccacctc caagactcct cttcttcctc     2340

ctcttcctga caccaatgga agtcaggcct gaggaacctc tagtggtgaa ggtggaagag     2400

ggagataacg ctgtgttaca gtgcctcaag ggaacctcag atggacccac tcagcagctg     2460

acctggtctc gggagtctcc gcttaaaccc ttcctgaaac tcagccttgg actgccaggt     2520

ctgggaatcc acatgaggcc actggctatc tggctgttca tcttcaacgt ctctcaacag     2580

atgggaggct tctacctgtg tcagcctgga ccaccttctg agaaggcatg gcagcctggt     2640

tggacagtca atgtggaggg ttctggtgag ctgttccggt ggaatgtttc ggacctaggt     2700

ggactgggat gtggtctgaa gaacaggtcc tcagagggac ctagctctcc ttccgggaag     2760

ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc ctgagatctg ggagggagag     2820

cctccgtgtg tcccaccgag ggacagcctg aaccagagcc tcagccagga cctcaccatg     2880

gcccctggct ccacactctg gctgtcctgt ggggtacccc ctgactctgt gtccaggggc     2940

cccctctcct ggacccatgt gcaccccaag gggcctaagt cattgctgag cctagagctg     3000

aaggacgatc gccctgccag agatatgtgg gtaatggaga cgggtctgtt gttgccccgg     3060

gccacagctc aagacgctgg aaagtattat tgtcaccgtg gcaacctgac catgtcattc     3120

cacctggaga tcactgctcg gccagtacta tggcactggc tgctgaggac tggtggctgg     3180

aaggtctcag ctgtgacttt ggcttatctg atcttctgcc tgtgttccct tgtgggcatt     3240

cttcatcttc aaagagccct ggtcctgagg aggaaaagat ga                        3282


<210>  327
<211>  3282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5v2-HvLv-intDS-41bb-3z-T-CD19t Top Strand

<400>  327
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaggtgcaa ctccagcagt ccggcgccga gctggtcagg      660

ccaggtgcat ccgtaactct gtcatgtaag gcgtccggat acaccttcac ggactacgaa      720

atgcattgga taaaacaaac tccagttcat gggttggagt ggattggctc catagacccg      780

gaaacgggag taacggcgta taaccagaaa ttcacgggga aagcgatagt aacggcagac      840

aagtctagta gcactgccta catggaactt agaagtctca caagtgaaga cagcgcggta      900

tattattgca cctccgatta tggatacttt aacgtttggg gtacgggcac gacagtgact      960

gttagttctg gaggcggagg atctggcgga gggggctctg gaggaggagg atctgatgtt     1020

gtaatgacgc agtctcaaaa gtttatgtca acgtctgttg gtgatcgcgt tagcattacc     1080

tgcaaagcat ctcaaagtgt aggatctgat gtggcatggt accagcaacg gcctggacgc     1140

tgtcctaaag cgctgattta tcttgcttct aaccggcata cgggggtccc agacaggttt     1200

actgggtctg gatctggaac ggactttaca ctgaccatat caaacgttca gtcagaggac     1260

ctggccgagt atttctgtca acaatataac atatacccct ataccttcgg tggaggaact     1320

aaattggaga taaaggagtc taagtacgga ccgccctgcc ccccttgccc tggccagcct     1380

agagaacccc aggtgtacac cctgcctccc agccaggaag agatgaccaa gaaccaggtg     1440

tccctgacct gcctggtcaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1500

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggcagc     1560

ttcttcctgt actcccggct gaccgtggac aagagccggt ggcaggaagg caacgtcttc     1620

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1680

agcctgggca agatgttctg ggtgctggtg gtggtcggag gcgtgctggc ctgctacagc     1740

ctgctggtca ccgtggcctt catcatcttt tgggtgaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcgggtgaa gttcagcaga     1920

agcgccgacg cccctgccta ccagcagggc cagaatcagc tgtacaacga gctgaacctg     1980

ggcagaaggg aagagtacga cgtcctggat aagcggagag gccgggaccc tgagatgggc     2040

ggcaagcctc ggcggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2100

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgggg caagggccac     2160

gacggcctgt atcagggcct gtccaccgcc accaaggata cctacgacgc cctgcacatg     2220

caggccctgc ccccaaggct cgagggcggc ggagagggca gaggaagtct tctaacatgc     2280

ggtgacgtgg aggagaatcc aggccctagg atgccacctc caagactcct cttcttcctc     2340

ctcttcctga caccaatgga agtcaggcct gaggaacctc tagtggtgaa ggtggaagag     2400

ggagataacg ctgtgttaca gtgcctcaag ggaacctcag atggacccac tcagcagctg     2460

acctggtctc gggagtctcc gcttaaaccc ttcctgaaac tcagccttgg actgccaggt     2520

ctgggaatcc acatgaggcc actggctatc tggctgttca tcttcaacgt ctctcaacag     2580

atgggaggct tctacctgtg tcagcctgga ccaccttctg agaaggcatg gcagcctggt     2640

tggacagtca atgtggaggg ttctggtgag ctgttccggt ggaatgtttc ggacctaggt     2700

ggactgggat gtggtctgaa gaacaggtcc tcagagggac ctagctctcc ttccgggaag     2760

ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc ctgagatctg ggagggagag     2820

cctccgtgtg tcccaccgag ggacagcctg aaccagagcc tcagccagga cctcaccatg     2880

gcccctggct ccacactctg gctgtcctgt ggggtacccc ctgactctgt gtccaggggc     2940

cccctctcct ggacccatgt gcaccccaag gggcctaagt cattgctgag cctagagctg     3000

aaggacgatc gccctgccag agatatgtgg gtaatggaga cgggtctgtt gttgccccgg     3060

gccacagctc aagacgctgg aaagtattat tgtcaccgtg gcaacctgac catgtcattc     3120

cacctggaga tcactgctcg gccagtacta tggcactggc tgctgaggac tggtggctgg     3180

aaggtctcag ctgtgacttt ggcttatctg atcttctgcc tgtgttccct tgtgggcatt     3240

cttcatcttc aaagagccct ggtcctgagg aggaaaagat ga                        3282


<210>  328
<211>  3282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5v1-LvHv-intDS-41bb-3z-T-CD19t Top Strand

<400>  328
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgatgttgta atgacgcagt ctcaaaagtt tatgtcaacg      660

tctgttggtg atcgcgttag cattacctgc aaagcatctc aaagtgtagg atctgatgtg      720

gcatggtacc agcaacggcc tggacgctgt cctaaagcgc tgatttatct tgcttctaac      780

cggcatacgg gggtcccaga caggtttact gggtctggat ctggaacgga ctttacactg      840

accatatcaa acgttcagtc agaggacctg gccgagtatt tctgtcaaca atataacata      900

tacccctata ccttcggtgg aggaactaaa ttggagataa agggaggcgg aggatctggc      960

ggagggggct ctggaggagg aggatctcag gtgcaactcc agcagtccgg cgccgagctg     1020

gtcaggccag gtgcatccgt aactctgtca tgtaaggcgt ccggatacac cttcacggac     1080

tacgaaatgc attggataaa acaaactcca gttcatgggt tggagtggat tggctccata     1140

gacccggaaa cgggagtaac ggcgtataac cagaaattca cggggaaagc gatagtaacg     1200

gcagacaagt ctagtagcac tgcctacatg gaacttagaa gtctcacaag tgaagacagc     1260

gcggtatatt attgcacctc cgattatgga tactttgacg tttggggtac gggcacgaca     1320

gtgactgtta gttctgagtc taagtacgga ccgccctgcc ccccttgccc tggccagcct     1380

agagaacccc aggtgtacac cctgcctccc agccaggaag agatgaccaa gaaccaggtg     1440

tccctgacct gcctggtcaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1500

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggcagc     1560

ttcttcctgt actcccggct gaccgtggac aagagccggt ggcaggaagg caacgtcttc     1620

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1680

agcctgggca agatgttctg ggtgctggtg gtggtcggag gcgtgctggc ctgctacagc     1740

ctgctggtca ccgtggcctt catcatcttt tgggtgaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcgggtgaa gttcagcaga     1920

agcgccgacg cccctgccta ccagcagggc cagaatcagc tgtacaacga gctgaacctg     1980

ggcagaaggg aagagtacga cgtcctggat aagcggagag gccgggaccc tgagatgggc     2040

ggcaagcctc ggcggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2100

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgggg caagggccac     2160

gacggcctgt atcagggcct gtccaccgcc accaaggata cctacgacgc cctgcacatg     2220

caggccctgc ccccaaggct cgagggcggc ggagagggca gaggaagtct tctaacatgc     2280

ggtgacgtgg aggagaatcc aggccctagg atgccacctc caagactcct cttcttcctc     2340

ctcttcctga caccaatgga agtcaggcct gaggaacctc tagtggtgaa ggtggaagag     2400

ggagataacg ctgtgttaca gtgcctcaag ggaacctcag atggacccac tcagcagctg     2460

acctggtctc gggagtctcc gcttaaaccc ttcctgaaac tcagccttgg actgccaggt     2520

ctgggaatcc acatgaggcc actggctatc tggctgttca tcttcaacgt ctctcaacag     2580

atgggaggct tctacctgtg tcagcctgga ccaccttctg agaaggcatg gcagcctggt     2640

tggacagtca atgtggaggg ttctggtgag ctgttccggt ggaatgtttc ggacctaggt     2700

ggactgggat gtggtctgaa gaacaggtcc tcagagggac ctagctctcc ttccgggaag     2760

ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc ctgagatctg ggagggagag     2820

cctccgtgtg tcccaccgag ggacagcctg aaccagagcc tcagccagga cctcaccatg     2880

gcccctggct ccacactctg gctgtcctgt ggggtacccc ctgactctgt gtccaggggc     2940

cccctctcct ggacccatgt gcaccccaag gggcctaagt cattgctgag cctagagctg     3000

aaggacgatc gccctgccag agatatgtgg gtaatggaga cgggtctgtt gttgccccgg     3060

gccacagctc aagacgctgg aaagtattat tgtcaccgtg gcaacctgac catgtcattc     3120

cacctggaga tcactgctcg gccagtacta tggcactggc tgctgaggac tggtggctgg     3180

aaggtctcag ctgtgacttt ggcttatctg atcttctgcc tgtgttccct tgtgggcatt     3240

cttcatcttc aaagagccct ggtcctgagg aggaaaagat ga                        3282


<210>  329
<211>  3282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5v2-LvHv-intDS-41bb-3z-T-CD19t Top Strand

<400>  329
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgatgttgta atgacgcagt ctcaaaagtt tatgtcaacg      660

tctgttggtg atcgcgttag cattacctgc aaagcatctc aaagtgtagg atctgatgtg      720

gcatggtacc agcaacggcc tggacgctgt cctaaagcgc tgatttatct tgcttctaac      780

cggcatacgg gggtcccaga caggtttact gggtctggat ctggaacgga ctttacactg      840

accatatcaa acgttcagtc agaggacctg gccgagtatt tctgtcaaca atataacata      900

tacccctata ccttcggtgg aggaactaaa ttggagataa agggaggcgg aggatctggc      960

ggagggggct ctggaggagg aggatctcag gtgcaactcc agcagtccgg cgccgagctg     1020

gtcaggccag gtgcatccgt aactctgtca tgtaaggcgt ccggatacac cttcacggac     1080

tacgaaatgc attggataaa acaaactcca gttcatgggt tggagtggat tggctccata     1140

gacccggaaa cgggagtaac ggcgtataac cagaaattca cggggaaagc gatagtaacg     1200

gcagacaagt ctagtagcac tgcctacatg gaacttagaa gtctcacaag tgaagacagc     1260

gcggtatatt attgcacctc cgattatgga tactttaacg tttggggtac gggcacgaca     1320

gtgactgtta gttctgagtc taagtacgga ccgccctgcc ccccttgccc tggccagcct     1380

agagaacccc aggtgtacac cctgcctccc agccaggaag agatgaccaa gaaccaggtg     1440

tccctgacct gcctggtcaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1500

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggcagc     1560

ttcttcctgt actcccggct gaccgtggac aagagccggt ggcaggaagg caacgtcttc     1620

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1680

agcctgggca agatgttctg ggtgctggtg gtggtcggag gcgtgctggc ctgctacagc     1740

ctgctggtca ccgtggcctt catcatcttt tgggtgaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcgggtgaa gttcagcaga     1920

agcgccgacg cccctgccta ccagcagggc cagaatcagc tgtacaacga gctgaacctg     1980

ggcagaaggg aagagtacga cgtcctggat aagcggagag gccgggaccc tgagatgggc     2040

ggcaagcctc ggcggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2100

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgggg caagggccac     2160

gacggcctgt atcagggcct gtccaccgcc accaaggata cctacgacgc cctgcacatg     2220

caggccctgc ccccaaggct cgagggcggc ggagagggca gaggaagtct tctaacatgc     2280

ggtgacgtgg aggagaatcc aggccctagg atgccacctc caagactcct cttcttcctc     2340

ctcttcctga caccaatgga agtcaggcct gaggaacctc tagtggtgaa ggtggaagag     2400

ggagataacg ctgtgttaca gtgcctcaag ggaacctcag atggacccac tcagcagctg     2460

acctggtctc gggagtctcc gcttaaaccc ttcctgaaac tcagccttgg actgccaggt     2520

ctgggaatcc acatgaggcc actggctatc tggctgttca tcttcaacgt ctctcaacag     2580

atgggaggct tctacctgtg tcagcctgga ccaccttctg agaaggcatg gcagcctggt     2640

tggacagtca atgtggaggg ttctggtgag ctgttccggt ggaatgtttc ggacctaggt     2700

ggactgggat gtggtctgaa gaacaggtcc tcagagggac ctagctctcc ttccgggaag     2760

ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc ctgagatctg ggagggagag     2820

cctccgtgtg tcccaccgag ggacagcctg aaccagagcc tcagccagga cctcaccatg     2880

gcccctggct ccacactctg gctgtcctgt ggggtacccc ctgactctgt gtccaggggc     2940

cccctctcct ggacccatgt gcaccccaag gggcctaagt cattgctgag cctagagctg     3000

aaggacgatc gccctgccag agatatgtgg gtaatggaga cgggtctgtt gttgccccgg     3060

gccacagctc aagacgctgg aaagtattat tgtcaccgtg gcaacctgac catgtcattc     3120

cacctggaga tcactgctcg gccagtacta tggcactggc tgctgaggac tggtggctgg     3180

aaggtctcag ctgtgacttt ggcttatctg atcttctgcc tgtgttccct tgtgggcatt     3240

cttcatcttc aaagagccct ggtcctgagg aggaaaagat ga                        3282


<210>  330
<211>  3285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7-LvHv-intDS-41bb-3z-T-CD19t Top Strand

<400>  330
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgatattcag atgacccaaa ctacgagttc cctgtctgcc      660

agccttggcg accgggtcac aattagttgc agggcttctc aggatatcaa ctactatttg      720

aactggtacc agcagaaacc tgatgggacg gtcaaacttc tcatctacta ttcatccaga      780

ctgcacagtg gcgtaccgtc tagattctca ggaagcggca gtggtacgga ttttagtctt      840

accattagta atctggaaca ggaggacatc gccacgtatt tttgccagca ggatgacgca      900

ctgccctata ccttcggcgg aggcactaag ttggagataa aaggaggcgg aggatctggc      960

ggagggggct ctggaggagg aggatctcaa gtacaacttc aacaaagtgg agccgaactg     1020

gtaaaacccg gagcgtctgt gaagattagt tgcaaggcat ccggttacgc cttctcaaat     1080

tattggatga actgggtaaa gcagcggccc ggaaagggtc tcgagtggat tgggcaaatc     1140

aacccagggg acggggatac gaactacaac ggtaagttca aaggcaaggc tacgttgacg     1200

gctgataaga gctcaagcac cgcttacatg cagttgtctt ctttgacaag tgaggatagt     1260

gccgtttact tctgcgcccg agaggaccga gattattttg attattgggg ccagggaaca     1320

actctcaccg tcagctccga gtctaagtac ggaccgccct gccccccttg ccctggccag     1380

cctagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag     1440

gtgtccctga cctgcctggt caaaggcttc taccccagcg atatcgccgt ggaatgggag     1500

agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1560

agcttcttcc tgtactcccg gctgaccgtg gacaagagcc ggtggcagga aggcaacgtc     1620

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1680

ctgagcctgg gcaagatgtt ctgggtgctg gtggtggtcg gaggcgtgct ggcctgctac     1740

agcctgctgg tcaccgtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     1800

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1860

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     1920

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     1980

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     2040

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     2100

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     2160

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     2220

atgcaggccc tgcccccaag gctcgagggc ggcggagagg gcagaggaag tcttctaaca     2280

tgcggtgacg tggaggagaa tccaggccct aggatgccac ctccaagact cctcttcttc     2340

ctcctcttcc tgacaccaat ggaagtcagg cctgaggaac ctctagtggt gaaggtggaa     2400

gagggagata acgctgtgtt acagtgcctc aagggaacct cagatggacc cactcagcag     2460

ctgacctggt ctcgggagtc tccgcttaaa cccttcctga aactcagcct tggactgcca     2520

ggtctgggaa tccacatgag gccactggct atctggctgt tcatcttcaa cgtctctcaa     2580

cagatgggag gcttctacct gtgtcagcct ggaccacctt ctgagaaggc atggcagcct     2640

ggttggacag tcaatgtgga gggttctggt gagctgttcc ggtggaatgt ttcggaccta     2700

ggtggactgg gatgtggtct gaagaacagg tcctcagagg gacctagctc tccttccggg     2760

aagctcatga gccccaagct gtatgtgtgg gccaaagacc gccctgagat ctgggaggga     2820

gagcctccgt gtgtcccacc gagggacagc ctgaaccaga gcctcagcca ggacctcacc     2880

atggcccctg gctccacact ctggctgtcc tgtggggtac cccctgactc tgtgtccagg     2940

ggccccctct cctggaccca tgtgcacccc aaggggccta agtcattgct gagcctagag     3000

ctgaaggacg atcgccctgc cagagatatg tgggtaatgg agacgggtct gttgttgccc     3060

cgggccacag ctcaagacgc tggaaagtat tattgtcacc gtggcaacct gaccatgtca     3120

ttccacctgg agatcactgc tcggccagta ctatggcact ggctgctgag gactggtggc     3180

tggaaggtct cagctgtgac tttggcttat ctgatcttct gcctgtgttc ccttgtgggc     3240

attcttcatc ttcaaagagc cctggtcctg aggaggaaaa gatga                     3285


<210>  331
<211>  3291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9G2-LvHv-intDS-41bb-3z-T-CD19t Top Strand

<400>  331
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc cgatatacaa atgactcaga caacgagcag tttgtccgca      660

tctcttggcg atcgagtaac tattagctgc aagacatccc aggacatata taattatttg      720

aattggtatc agcagaaacc ggacggaact gtcaaactcc tcatttatta tacctccagg      780

cttcatagtg gggttccttc ccgatttagt ggaggaggct caggtacgga ctacagcctg      840

acgatttcca accttgaaca agaagatata gctacatact tctgtcagca aggtgacacc      900

ttgccctgga cattcggtgg gggtacaaaa ctcgaaataa agggaggcgg aggatctggc      960

ggagggggct ctggaggagg aggatctgag gtcaagcttg tcgagtcaga gggaggtttg     1020

gtccagccgg gttcttctat gaaactctcc tgcacagcca gtggctttac atttagtgat     1080

tactacatga gttgggtgag acaggtgcct gagaaagggc tggagtgggt agcttccatt     1140

aactacgacg gaggtagcac ctattacttg gactccttga aaagcagatt cataatttcc     1200

agggataata cgaaaaacat actttatctt caaatgtcct ctttgaagag cgaggacaca     1260

gccacatact attgcgccag ggatagaggc gatggtgatt attttgacta ttggggacag     1320

ggcacaacac tcacggtcag cagcgagtct aagtacggac cgccctgccc cccttgccct     1380

ggccagccta gagaacccca ggtgtacacc ctgcctccca gccaggaaga gatgaccaag     1440

aaccaggtgt ccctgacctg cctggtcaaa ggcttctacc ccagcgatat cgccgtggaa     1500

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1560

gacggcagct tcttcctgta ctcccggctg accgtggaca agagccggtg gcaggaaggc     1620

aacgtcttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1680

ctgagcctga gcctgggcaa gatgttctgg gtgctggtgg tggtcggagg cgtgctggcc     1740

tgctacagcc tgctggtcac cgtggccttc atcatctttt gggtgaaacg gggcagaaag     1800

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1860

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgggtgaag     1920

ttcagcagaa gcgccgacgc ccctgcctac cagcagggcc agaatcagct gtacaacgag     1980

ctgaacctgg gcagaaggga agagtacgac gtcctggata agcggagagg ccgggaccct     2040

gagatgggcg gcaagcctcg gcggaagaac ccccaggaag gcctgtataa cgaactgcag     2100

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcggggc     2160

aagggccacg acggcctgta tcagggcctg tccaccgcca ccaaggatac ctacgacgcc     2220

ctgcacatgc aggccctgcc cccaaggctc gagggcggcg gagagggcag aggaagtctt     2280

ctaacatgcg gtgacgtgga ggagaatcca ggccctagga tgccacctcc aagactcctc     2340

ttcttcctcc tcttcctgac accaatggaa gtcaggcctg aggaacctct agtggtgaag     2400

gtggaagagg gagataacgc tgtgttacag tgcctcaagg gaacctcaga tggacccact     2460

cagcagctga cctggtctcg ggagtctccg cttaaaccct tcctgaaact cagccttgga     2520

ctgccaggtc tgggaatcca catgaggcca ctggctatct ggctgttcat cttcaacgtc     2580

tctcaacaga tgggaggctt ctacctgtgt cagcctggac caccttctga gaaggcatgg     2640

cagcctggtt ggacagtcaa tgtggagggt tctggtgagc tgttccggtg gaatgtttcg     2700

gacctaggtg gactgggatg tggtctgaag aacaggtcct cagagggacc tagctctcct     2760

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     2820

gagggagagc ctccgtgtgt cccaccgagg gacagcctga accagagcct cagccaggac     2880

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2940

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     3000

ctagagctga aggacgatcg ccctgccaga gatatgtggg taatggagac gggtctgttg     3060

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     3120

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     3180

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     3240

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagatg a              3291


<210>  332
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 scFv VH-VL orientation

<400>  332

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr 
65                  70                  75                  80  


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
                165                 170                 175     


Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
    210                 215                 220                 


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
225                 230                 235                 240 


Gln Gln Asp Asp Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys 
            


<210>  333
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 scFv VL-VH orientation

<400>  333

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  334
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 scFv VH-VL orientation

<400>  334

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Ser Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Val Pro Glu Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Leu Asp Ser Leu Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
                165                 170                 175     


Cys Lys Thr Ser Gln Asp Ile Tyr Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
        195                 200                 205             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys 
            260     


<210>  335
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 scFv VL-VH orientation

<400>  335

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Lys Thr Ser Gln Asp 
        35                  40                  45              


Ile Tyr Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser Ser Met 
145                 150                 155                 160 


Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met 
                165                 170                 175     


Ser Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val Ala Ser 
            180                 185                 190         


Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu Lys Ser 
        195                 200                 205             


Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr Leu Gln 
    210                 215                 220                 


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                245                 250                 255     


Leu Thr Val Ser Ser 
            260     


<210>  336
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 scFv VH-VL orientation

<400>  336

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr 
65                  70                  75                  80  


Asn Gly Gln Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly Glu Arg Val Thr 
                165                 170                 175     


Ile Asn Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile Tyr Tyr Ala Thr 
        195                 200                 205             


Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Asp Asp Thr Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Leu His His Gly Glu Ser Pro Trp Thr Phe Gly Glu 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys 
            260             


<210>  337
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 scFv VL-VH orientation

<400>  337

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser 
            260             


<210>  338
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 scFv VH-VL orientation

<400>  338

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ser Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Gln Lys 
145                 150                 155                 160 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Ser Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Arg Cys Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
225                 230                 235                 240 


Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys 
        


<210>  339
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 scFv VL-VH orientation

<400>  339

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met 
                165                 170                 175     


His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ser 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr Gly 
        195                 200                 205             


Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Ser 
225                 230                 235                 240 


Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  340
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 scFv VH-VL orientation

<400>  340

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ser Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Gln Lys 
145                 150                 155                 160 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Ser Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Arg Cys Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
225                 230                 235                 240 


Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys 
        


<210>  341
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 scFv VL-VH orientation

<400>  341

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met 
                165                 170                 175     


His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ser 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr Gly 
        195                 200                 205             


Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Ser 
225                 230                 235                 240 


Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  342
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  342
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggctat ggatccaaat       60

ttctggctgc aagtgcagga gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc      120

tgcactttct tccatcccat accctactac gacaagaact ccccagttca tggttactgg      180

ttccgggaag gagccattat atccagggac tctccagtgg ccacaaacaa gctagatcaa      240

gaagtacagg aggagactca gggcagattc cgcctccttg gggatcccag taggaacaac      300

tgctccctga gcatcgtaga cgccaggagg agggataatg gttcatactt ctttcggatg      360

gagagaggaa gtaccaaata cagttacaaa tctccccagc tctctgtgca tgtgacagac      420

ttgacccaca ggcccaaaat cctcatccct ggcactctag aacccggcca ctccaaaaac      480

ctgacctgct ctgtgtcctg ggcctgtgag cagggaacac ccccgatctt ctcctggttg      540

tcagctgccc ccacctccct gggccccagg actactcact cctcggtgct cataatcacc      600

ccacggcccc aggaccacgg caccaacctg acctgtcagg tgaagttcgc tggagctggt      660

gtgactacgg agagaaccat ccagctcaac gtcacctatg ttccacagaa cccaacaact      720

ggtatctttc caggagatgg ctcagggaaa caagagacca gagcaggagt ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cccacaggag gaaagcagcc aggacagcag tgggcaggaa tgacacccac      900

cctaccacag ggtcagcctc cccgaaacac cagaagaagt ccaagttaca tggccccact      960

gaaacctcaa gctgttcagg tgccgcccct actgtggaga tggatgagga gctgcattat     1020

gcttccctca actttcatgg gatgaatcct tccaaggaca cctccaccga atactcagag     1080

gtcaggaccc ag                                                         1092


<210>  343
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  344
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 9G2 and/or 6H9

<400>  344

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  345
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 3A5v1, 3A5v2, and/or 2D5

<400>  345

Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly 
            20  


<210>  346
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 7D5v1 and/or 7D5v2

<400>  346

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Thr Arg Cys 
            


<210>  347
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 11D5

<400>  347

Met Arg Phe Ser Ala Gln Leu Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Glu Ser Thr Ala 
            20  


<210>  348
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 6H9

<400>  348

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  349
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 3A5v1 and/or 3A5v2

<400>  349

Met Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Val Ile Ala Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  350
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 7D5v1 and/or 7D5v2

<400>  350

Met Ala Val Leu Ala Leu Leu Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Thr Leu Ser 
            


<210>  351
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 2D5

<400>  351

Met Glu Trp Ser Trp Val Cys Leu Phe Leu Leu Ser Val Ile Ala Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  352
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 11D5

<400>  352

Met Glu Ser Asn Trp Ile Leu Pro Phe Ile Leu Ser Val Thr Ser Gly 
1               5                   10                  15      


Val Tyr Ser 
            


<210>  353
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 13E11

<400>  353

Met Glu Trp Cys Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  354
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  My96 coding sequence

<400>  354
gagatcgtgc tgacacagag ccctggaagc ctggccgtgt ctcctggcga gcgcgtgaca       60

atgagctgca agagcagcca gagcgtgttc ttcagcagct cccagaagaa ctacctggcc      120

tggtatcagc agatccccgg ccagagcccc agactgctga tctactgggc cagcaccaga      180

gaaagcggcg tgcccgatag attcaccggc agcggctctg gcaccgactt caccctgaca      240

atcagcagcg tgcagcccga ggacctggcc atctactact gccaccagta cctgagcagc      300

cggacctttg gccagggcac caagctggaa atcaagagag gcggcggagg ctctggcgga      360

ggcggatcta gtggcggagg atctcaggtg cagctgcagc agcctggcgc cgaggtcgtg      420

aaacctggcg cctctgtgaa gatgtcctgc aaggccagcg gctacacctt caccagctac      480

tacatccact ggatcaagca gacccctgga cagggcctgg aatgggtggg agtgatctac      540

cccggcaacg acgacatcag ctacaaccag aagttccagg gcaaggccac cctgaccgcc      600

gacaagtcta gcaccaccgc ctacatgcag ctgtccagcc tgaccagcga ggacagcgcc      660

gtgtactact gcgccagaga agtgcggctg cggtacttcg atgtgtgggg ccagggaacc      720

accgtgaccg tgtcatct                                                    738


<210>  355
<211>  9278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  My96_int_41BB_3z_TCD19 coding sequence

<400>  355
gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc       60

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      120

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      180

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      240

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      300

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      360

attagatcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat ataaattaaa      420

acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg gcctgttaga      480

aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc agacaggatc      540

agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc atcaaaggat      600

agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa acaaaagtaa      660

gaaaaaagca cagcaagcag cagctgacac aggacacagc aatcaggtca gccaaaatta      720

ccctatagtg cagaacatcc aggggcaaat ggtacatcag gccatatcac ctagaacttt      780

aaatgcatgg gtaaaagtag tagaagagaa ggctttcagc ccagaagtga tacccatgtt      840

ttcagcatta tcagaaggag ccaccccaca agatttaaac accatgctaa acacagtggg      900

gggacatcaa gcagccatgc aaatgttaaa agagaccatc aatgaggaag ctgcaggcaa      960

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     1020

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     1080

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     1140

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     1200

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     1260

tcatttgcac cactgctgtg ccttggatct acaaatggca gtattcatcc acaattttaa     1320

aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac     1380

agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttcgggttta     1440

ttacagggac agcagagatc cagtttgggg atcaattgca tgaagaatct gcttagggtt     1500

aggcgttttg cgctgcttcg cgaggatctg cgatcgctcc ggtgcccgtc agtgggcaga     1560

gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc     1620

ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt     1680

tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg     1740

caacgggttt gccgccagaa cacagctgaa gcttcgaggg gctcgcatct ctccttcacg     1800

cgcccgccgc cctacctgag gccgccatcc acgccggttg agtcgcgttc tgccgcctcc     1860

cgcctgtggt gcctcctgaa ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag     1920

accgggcctt tgtccggcgc tcccttggag cctacctaga ctcagccggc tctccacgct     1980

ttgcctgacc ctgcttgctc aactctacgt ctttgtttcg ttttctgttc tgcgccgtta     2040

cagatccaag ctgtgaccgg cgcctacggc tagccaccat gctgctgctc gtgaccagcc     2100

tgctgctgtg cgaactgccc caccctgcct ttctgctgat ccccgagatc gtgctgacac     2160

agagccctgg aagcctggcc gtgtctcctg gcgagcgcgt gacaatgagc tgcaagagca     2220

gccagagcgt gttcttcagc agctcccaga agaactacct ggcctggtat cagcagatcc     2280

ccggccagag ccccagactg ctgatctact gggccagcac cagagaaagc ggcgtgcccg     2340

atagattcac cggcagcggc tctggcaccg acttcaccct gacaatcagc agcgtgcagc     2400

ccgaggacct ggccatctac tactgccacc agtacctgag cagccggacc tttggccagg     2460

gcaccaagct ggaaatcaag agaggcggcg gaggctctgg cggaggcgga tctagtggcg     2520

gaggatctca ggtgcagctg cagcagcctg gcgccgaggt cgtgaaacct ggcgcctctg     2580

tgaagatgtc ctgcaaggcc agcggctaca ccttcaccag ctactacatc cactggatca     2640

agcagacccc tggacagggc ctggaatggg tgggagtgat ctaccccggc aacgacgaca     2700

tcagctacaa ccagaagttc cagggcaagg ccaccctgac cgccgacaag tctagcacca     2760

ccgcctacat gcagctgtcc agcctgacca gcgaggacag cgccgtgtac tactgcgcca     2820

gagaagtgcg gctgcggtac ttcgatgtgt ggggccaggg aaccaccgtg accgtgtcat     2880

ctgagtctaa gtacggaccg ccctgccccc cttgccctat gttctgggtg ctggtggtgg     2940

tcggaggcgt gctggcctgc tacagcctgc tggtcaccgt ggccttcatc atcttttggg     3000

tgaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac     3060

aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat     3120

gtgaactgcg ggtgaagttc agcagaagcg ccgacgcccc tgcctaccag cagggccaga     3180

atcagctgta caacgagctg aacctgggca gaagggaaga gtacgacgtc ctggataagc     3240

ggagaggccg ggaccctgag atgggcggca agcctcggcg gaagaacccc caggaaggcc     3300

tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc ggcatgaagg     3360

gcgagcggag gcggggcaag ggccacgacg gcctgtatca gggcctgtcc accgccacca     3420

aggataccta cgacgccctg cacatgcagg ccctgccccc aaggctcgag ggcggcggag     3480

agggcagagg aagtcttcta acatgcggtg acgtggagga gaatccaggc cctaggatgc     3540

cacctccaag actcctcttc ttcctcctct tcctgacacc aatggaagtc aggcctgagg     3600

aacctctagt ggtgaaggtg gaagagggag ataacgctgt gttacagtgc ctcaagggaa     3660

cctcagatgg acccactcag cagctgacct ggtctcggga gtctccgctt aaacccttcc     3720

tgaaactcag ccttggactg ccaggtctgg gaatccacat gaggccactg gctatctggc     3780

tgttcatctt caacgtctct caacagatgg gaggcttcta cctgtgtcag cctggaccac     3840

cttctgagaa ggcatggcag cctggttgga cagtcaatgt ggagggttct ggtgagctgt     3900

tccggtggaa tgtttcggac ctaggtggac tgggatgtgg tctgaagaac aggtcctcag     3960

agggacctag ctctccttcc gggaagctca tgagccccaa gctgtatgtg tgggccaaag     4020

accgccctga gatctgggag ggagagcctc cgtgtgtccc accgagggac agcctgaacc     4080

agagcctcag ccaggacctc accatggccc ctggctccac actctggctg tcctgtgggg     4140

taccccctga ctctgtgtcc aggggccccc tctcctggac ccatgtgcac cccaaggggc     4200

ctaagtcatt gctgagccta gagctgaagg acgatcgccc tgccagagat atgtgggtaa     4260

tggagacggg tctgttgttg ccccgggcca cagctcaaga cgctggaaag tattattgtc     4320

accgtggcaa cctgaccatg tcattccacc tggagatcac tgctcggcca gtactatggc     4380

actggctgct gaggactggt ggctggaagg tctcagctgt gactttggct tatctgatct     4440

tctgcctgtg ttcccttgtg ggcattcttc atcttcaaag agccctggtc ctgaggagga     4500

aaagatgagc ggccgctcta gacccgggct gcaggaattc gatatcaagc ttatcgataa     4560

tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc     4620

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat     4680

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg     4740

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg     4800

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat     4860

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt     4920

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc     4980

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa     5040

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg     5100

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcatc gataccgtcg     5160

actagccgta cctttaagac caatgactta caaggcagct gtagatctta gccacttttt     5220

aaaagaaaag gggggactgg aagggctaat tcactcccaa agaagacaag atctgctttt     5280

tgcctgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact     5340

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc     5400

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa     5460

aatctctagc agaattcgat atcaagctta tcgataccgt cgacctcgag ggggggcccg     5520

gtacccaatt cgccctatag tgagtcgtat tacaattcac tggccgtcgt tttacaacgt     5580

cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc     5640

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     5700

ctgaatggcg aatggaaatt gtaagcgtta atattttgtt aaaattcgcg ttaaattttt     5760

gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg caaaatccct tataaatcaa     5820

aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt ccactattaa     5880

agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat ggcccactac     5940

gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga     6000

accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac gtggcgagaa     6060

aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc     6120

tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg tcaggtggca     6180

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     6240

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     6300

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     6360

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     6420

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     6480

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     6540

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     6600

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     6660

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     6720

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     6780

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     6840

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     6900

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     6960

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     7020

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     7080

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     7140

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     7200

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     7260

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     7320

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     7380

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     7440

aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt     7500

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     7560

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     7620

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     7680

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     7740

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     7800

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     7860

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     7920

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     7980

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     8040

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     8100

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     8160

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     8220

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     8280

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc     8340

tcgaaattaa ccctcactaa agggaacaaa agctggagct ccaccgcggt ggcggcctcg     8400

aggtcgagat ccggtcgacc agcaaccata gtcccgcccc taactccgcc catcccgccc     8460

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     8520

gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt     8580

ggaggcctag gcttttgcaa aaagcttcga cggtatcgat tggctcatgt ccaacattac     8640

cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag     8700

ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct     8760

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc     8820

caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg     8880

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat     8940

ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca     9000

tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc     9060

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga     9120

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat     9180

tgacgcaaat gggcggtagg cgtgtacgga attcggagtg gcgagccctc agatcctgca     9240

tataagcagc tgctttttgc ctgtactggg tctctctg                             9278


<210>  356
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 variable light chain

<400>  356

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp Ala Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  357
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 variable heavy chain

<400>  357

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  358
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6H9 variable light chain

<400>  358

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  359
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6H9 variable heavy chain

<400>  359

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Asp Gly Gly Asn Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Gly Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser 
        115             


<210>  360
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 variable light chain

<400>  360

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Thr Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  361
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 variable heavy chain

<400>  361

Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  362
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 variable light chain

<400>  362

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Val Trp Tyr His Lys Lys Pro Gly Gln Ser Pro Lys Gly Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asp Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  363
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 variable heavy chain

<400>  363

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asp Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Arg Ile Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Thr Ser Asp Tyr Asp Tyr Phe Gly Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  364
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variable light chain

<400>  364

Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Ser Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  365
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 variable heavychain

<400>  365

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  366
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-set directed CD33 scFv

<400>  366

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  367
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 variable heavy chain

<400>  367

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  368
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D5 variable light chain

<400>  368

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Phe Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile His Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  369
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D5 variant 1 variable heavy chain

<400>  369

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Leu Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Gly Thr Gly Thr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  370
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V-set directed CD33 scFv coding sequence

<400>  370
caagttcagc tcgtgcagag tggtgcagag gtcaagaagc ctggagagag cgtcaaggtc       60

agctgtaaag catctggcta tacattcact aattacggaa tgaactgggt caagcaggcg      120

ccaggtcagg gacttgaatg gatgggctgg ataaacacat atacaggaga gccaacttat      180

gctgacaaat tccagggtag agtcacgatg acgacggaca catcaacctc caccgcgtat      240

atggaaatca ggaatttggg cggagacgat acagcggttt actactgcgc ccgatggagt      300

tggtctgatg gctattatgt gtatttcgac tactggggtc agggtacaag cgtcacagta      360

agttcaggag gcggaggatc tggcggaggg ggctctggag gaggaggatc tgatattgta      420

atgacccaat cccctgactc attgacagta tccctcggag agcggaccac tataaactgc      480

aaatccagcc agtctgtatt ggactccagc accaacaaaa atagccttgc gtggtatcag      540

caaaagccgg gtcaaccacc caagctgctc ttgagttggg cgagtaccag agagagtggg      600

atacccgaca ggtttagtgg atctggctct ggcaccgatt ttacgcttac aatcgacagt      660

ccgcaacccg aagactccgc gacgtactac tgtcagcaat ctgcacactt tccaataacc      720

ttcgggcaag ggacacggct ggagatcaaa                                       750


<210>  371
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D5 variant 2 variable heavy chain

<400>  371

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Leu Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Gly Thr Gly Thr Gly Asp His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  372
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 variable light chain

<400>  372

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  373
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 variable heavy chain

<400>  373

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  374
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F5 variable light chain

<400>  374

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Tyr Asn Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  375
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F5 variable heavy chain

<400>  375

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Met Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  376
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B12 variable light chain

<400>  376

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  377
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-set directed CD33/CD3 BsAb (RC1)

<400>  377

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
65                  70                  75                  80  


Ala Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn 
            180                 185                 190         


Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser 
225                 230                 235                 240 


Pro Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His 
                245                 250                 255     


Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    290                 295                 300                 


Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
            340                 345                 350         


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
    370                 375                 380                 


Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
            420                 425                 430         


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
        435                 440                 445             


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
    450                 455                 460                 


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                485                 490                 495     


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
            500                 505                 510         


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu His His His 
        515                 520                 525             


His His His 
    530     


<210>  378
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-set directed CD33/CD3 BsAb (RC1) without leader sequence or His
       tag

<400>  378

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


