                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Rohatgi, Rajat
 
<120>  HIGH-POTENCY AGONISTS AND ANTAGONISTS OF THE WNT SIGNALING 
       PATHWAY

<130>  STAN-1673WO

<150>  US 63/007,057
<151>  2020-04-08

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met 
1               5                   10                  15      


Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg 
            20                  25                  30          


Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys 
        35                  40                  45              


Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala 
    50                  55                  60                  


Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys 
65                  70                  75                  80  


Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr 
                85                  90                  95      


Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn 
        115                 120                 125             


Cys Pro Glu Gly Leu Glu Ala Asn Asn His Thr Met Glu Cys Val Ser 
    130                 135                 140                 


Ile Val His Cys Glu Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr 
145                 150                 155                 160 


Lys Lys Gly Lys Thr Cys Gly Phe Lys Arg Gly Thr Glu Thr Arg Val 
                165                 170                 175     


Arg Glu Ile Ile Gln His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro 
            180                 185                 190         


Thr Asn Glu Thr Arg Lys Cys Thr Val Gln Arg Lys Lys Cys Gln Lys 
        195                 200                 205             


Gly Glu Arg Gly Lys Lys Gly Arg Glu Arg Lys Arg Lys Lys Pro Asn 
    210                 215                 220                 


Lys Gly Glu Ser Lys Glu Ala Ile Pro Asp Ser Lys Ser Leu Glu Ser 
225                 230                 235                 240 


Ser Lys Glu Ile Pro Glu Gln Arg Glu Asn Lys Gln Gln Gln Lys Lys 
                245                 250                 255     


Arg Lys Val Gln Asp Lys Gln Lys Ser Val Ser Val Ser Thr Val His 
            260                 265                 270         


<210>  2
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met 
1               5                   10                  15      


Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala 
            20                  25                  30          


Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys 
        35                  40                  45              


Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg 
    50                  55                  60                  


Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser 
65                  70                  75                  80  


Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys 
                85                  90                  95      


Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys 
            100                 105                 110         


Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys 
        115                 120                 125             


Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr Met Glu Cys Val Glu Gly 
    130                 135                 140                 


Cys Glu Val Gly His Trp Ser Glu Trp Gly Thr Cys Ser Arg Asn Asn 
145                 150                 155                 160 


Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu Thr Arg Thr Arg Gln Ile 
                165                 170                 175     


Val Lys Lys Pro Val Lys Asp Thr Ile Leu Cys Pro Thr Ile Ala Glu 
            180                 185                 190         


Ser Arg Arg Cys Lys Met Thr Met Arg His Cys Pro Gly Gly Lys Arg 
        195                 200                 205             


Thr Pro Lys Ala Lys Glu Lys Arg Asn Lys Lys Lys Lys Arg Lys Leu 
    210                 215                 220                 


Ile Glu Arg Ala Gln Glu Gln His Ser Val Phe Leu Ala Thr Asp Arg 
225                 230                 235                 240 


Ala Asn Gln 
            


<210>  3
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Gln Lys Gln Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Arg Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Gln Lys Gln Gly Leu Pro Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Arg Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asn Ala Ser Met Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Arg 
    210                 215                 220                 


Gly Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  6
<211>  815
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa agaattggca      180

tgaagcagat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg cactgtgagg      420

tcagtgaatg gaatccttgg agtccatgca cgaagaaggg aaaaacatgt ggcttcaaaa      480

gagggactga aacacgggtc cgagaaataa tacagcatcc ttcagcaaag ggtaacctgt      540

gtcccccaac aaatgagaca agaaagtgta cagtgcaaag gaagaagtgt cagaagggag      600

aacgaggaaa aaaaggaagg gagaggaaaa gaaaaaaacc taataaagga gaaagtaaag      660

aagcaatacc tgacagcaaa agtctggaat ccagcaaaga aatcccagag caacgagaaa      720

acaaacagca gcagaagaag cgaaaagtcc aagataaaca gaaatcggta tcagtcagca      780

ctgtacactt ggtaccaacc accgagaacc tgtac                                 815


<210>  7
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Arg Ile Gly 
        35                  40                  45              


Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val His Cys Glu 
        115                 120                 125             


Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr Lys Lys Gly Lys Thr 
    130                 135                 140                 


Cys Gly Phe Lys Arg Gly Thr Glu Thr Arg Val Arg Glu Ile Ile Gln 
145                 150                 155                 160 


His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro Thr Asn Glu Thr Arg 
                165                 170                 175     


Lys Cys Thr Val Gln Arg Lys Lys Cys Gln Lys Gly Glu Arg Gly Lys 
            180                 185                 190         


Lys Gly Arg Glu Arg Lys Arg Lys Lys Pro Asn Lys Gly Glu Ser Lys 
        195                 200                 205             


Glu Ala Ile Pro Asp Ser Lys Ser Leu Glu Ser Ser Lys Glu Ile Pro 
    210                 215                 220                 


Glu Gln Arg Glu Asn Lys Gln Gln Gln Lys Lys Arg Lys Val Gln Asp 
225                 230                 235                 240 


Lys Gln Lys Ser Val Ser Val Ser Thr Val His 
                245                 250     


<210>  8
<211>  815
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa agaattggca      180

tgaagcagat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg cactgtgagg      420

tcagtgaatg gaatccttgg agtccatgca cgaagaaggg aaaaacatgt ggcttcgaaa      480

gagggactga aacacgggtc cgagaaataa tacagcatcc ttcagcaaag ggtaacctgt      540

gtcccccaac aaatgagaca agagagtgta cagtgcaaga gaaggagtgt caggagggag      600

aacgaggaga aaaaggagag gaggagaaag agaaagaacc taataaagga gaaagtaaag      660

aagcaatacc tgacagcaaa agtctggaat ccagcaaaga aatcccagag caacgagaaa      720

acaaacagca gcaggagaag gaaaaagtcc aagataaaca gaaatcggta tcagtcagca      780

ctgtacactt ggtaccaacc accgagaacc tgtac                                 815


<210>  9
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Arg Ile Gly 
        35                  40                  45              


Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val His Cys Glu 
        115                 120                 125             


Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr Lys Lys Gly Lys Thr 
    130                 135                 140                 


Cys Gly Phe Glu Arg Gly Thr Glu Thr Arg Val Arg Glu Ile Ile Gln 
145                 150                 155                 160 


His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro Thr Asn Glu Thr Arg 
                165                 170                 175     


Glu Cys Thr Val Gln Glu Lys Glu Cys Gln Glu Gly Glu Arg Gly Glu 
            180                 185                 190         


Lys Gly Glu Glu Glu Lys Glu Lys Glu Pro Asn Lys Gly Glu Ser Lys 
        195                 200                 205             


Glu Ala Ile Pro Asp Ser Lys Ser Leu Glu Ser Ser Lys Glu Ile Pro 
    210                 215                 220                 


Glu Gln Arg Glu Asn Lys Gln Gln Gln Glu Lys Glu Lys Val Gln Asp 
225                 230                 235                 240 


Lys Gln Lys Ser Val Ser Val Ser Thr Val His 
                245                 250     


<210>  10
<211>  437
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa agaattggca      180

tgaagcagat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg ttggtaccaa      420

ccaccgagaa cctgtac                                                     437


<210>  11
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Arg Ile Gly 
        35                  40                  45              


Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val 
        115                 120                 125 


<210>  12
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa agaattggca      180

tgaagcagat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg agtaccggag      420

gttcaggggg aagcggaggt tccggtatgg aggtccaact tctcgaaagc ggtggtggtc      480

ttgtccaacc aggagggtca ctccgcttgt cctgcgcagc ttctggtttc actttttcaa      540

gctatgcgat gagctgggtg cgccaggccc ctgggaaagg gttggaatgg gtcagcacga      600

tacaaaaaca agggcttcca actcaatatg cagacagcgt gaaaggacgg tttacaattt      660

cacgagacaa tagcaaaaat acgttgtatt tgcaaatgaa ttcactgcga gcggaagaca      720

cagcagtcta ttattgtgca aagaataggg ccaagtttga ttactggggt caagggacgc      780

tcgttaccgt tagcagtggt ggaggagggt ctgggggcgg cggtagcggg ggaggcggaa      840

gtgacatcca gatgacacaa agtccttcat ccctgagcgc aagtgttggg gatcgcgtta      900

ccattacctg ccgcgcttcc caaagtatct cttcttatct caactggtat caacaaaaac      960

cgggcaaagc gcctaagttg ttgatctacg cagcgtcaat gctccaaagc ggtgttccaa     1020

gcagattctc cggcagtggc tcagggacgg actttacgct tacgatatct agccttcagc     1080

cggaagactt tgcaacatat tactgccagc agaatcgagg ctttccactt acttttgggc     1140

agggtacgaa agtggaaata aaaggtaccg gaggttccgg tggttccg                  1188


<210>  13
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Arg Ile Gly 
        35                  40                  45              


Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val Ser Thr Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Met Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Gln Lys Gln 
            180                 185                 190         


Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asn Arg Ala Lys 
225                 230                 235                 240 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            260                 265                 270         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        275                 280                 285             


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
305                 310                 315                 320 


Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            340                 345                 350         


Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu Thr Phe Gly 
        355                 360                 365             


Gln Gly Thr Lys Val Glu Ile Lys 
    370                 375     


<210>  14
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa agaattggca      180

tgaagcagat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg agtaccggag      420

gttcaggggg aagcggaggt tccggtatgg aggtccaact tctcgaaagc ggtggtggtc      480

ttgtccaacc aggagggtca ctccgcttgt cctgcgcagc ttctggtttc actttttcaa      540

gctatgcgat gagctgggtg cgccaggccc ctgggaaagg gttggaatgg gtcagcacga      600

tacaaaaaca agggcttcca actcaatatg cagacagcgt gaaaggacgg tttacaattt      660

cacgagacaa tagcaaaaat acgttgtatt tgcaaatgaa ttcactgcga gcggaagaca      720

cagcagtcta ttattgtagc ggtggaggaa gtggaggagg atcttggggt caagggacgc      780

tcgttaccgt tagcagtggt ggaggagggt ctgggggcgg cggtagcggg ggaggcggaa      840

gtgacatcca gatgacacaa agtccttcat ccctgagcgc aagtgttggg gatcgcgtta      900

ccattacctg ccgcgcttcc caaagtatct cttcttatct caactggtat caacaaaaac      960

cgggcaaagc gcctaagttg ttgatctacg cagcgtcaat gctccaaagc ggtgttccaa     1020

gcagattctc cggcagtggc tcagggacgg actttacgct tacgatatct agccttcagc     1080

cggaagactt tgcaacatat tactgccagc agaatcgagg ctttccactt acttttgggc     1140

agggtacgaa agtggaaata aaaggtaccg gaggttccgg tggttccg                  1188


<210>  15
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Arg Ile Gly 
        35                  40                  45              


Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val Ser Thr Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Met Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Gln Lys Gln 
            180                 185                 190         


Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            260                 265                 270         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        275                 280                 285             


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
305                 310                 315                 320 


Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            340                 345                 350         


Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu Thr Phe Gly 
        355                 360                 365             


Gln Gly Thr Lys Val Glu Ile Lys 
    370                 375     


<210>  16
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa agaattggca      180

tgaagcagat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg agtaccggag      420

gttcaggggg aagcggaggt tccggtatgg aggtccaact tctcgaaagc ggtggtggtc      480

ttgtccaacc aggagggtca ctccgcttgt cctgcgcagc ttctggtttc actttttcaa      540

gctatgcgat gagctgggtg cgccaggccc ctgggaaagg gttggaatgg gtcagcacga      600

tacaaaaaca agggcttcca actcaatatg cagacagcgt gaaaggacgg tttacaattt      660

cacgagacaa tagcaaaaat acgttgtatt tgcaaatgaa ttcactgcga gcggaagaca      720

cagcagtcta ttattgtgca gctgcggctg ccgccgcagc agcttggggt caagggacgc      780

tcgttaccgt tagcagtggt ggaggagggt ctgggggcgg cggtagcggg ggaggcggaa      840

gtgacatcca gatgacacaa agtccttcat ccctgagcgc aagtgttggg gatcgcgtta      900

ccattacctg ccgcgcttcc caaagtatct cttcttatct caactggtat caacaaaaac      960

cgggcaaagc gcctaagttg ttgatctacg cagcgtcaat gctccaaagc ggtgttccaa     1020

gcagattctc cggcagtggc tcagggacgg actttacgct tacgatatct agccttcagc     1080

cggaagactt tgcaacatat tactgccagc agaatcgagg ctttccactt acttttgggc     1140

agggtacgaa agtggaaata aaaggtaccg gaggttccgg tggttccg                  1188


<210>  17
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Arg Ile Gly 
        35                  40                  45              


Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val Ser Thr Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Met Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Gln Lys Gln 
            180                 185                 190         


Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            260                 265                 270         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        275                 280                 285             


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
305                 310                 315                 320 


Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            340                 345                 350         


Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu Thr Phe Gly 
        355                 360                 365             


Gln Gly Thr Lys Val Glu Ile Lys 
    370                 375     


<210>  18
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa gccattggca      180

tgaaggccat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtttc aacaaaaatt      300

tctgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg agtaccggag      420

gttcaggggg aagcggaggt tccggtatgg aggtccaact tctcgaaagc ggtggtggtc      480

ttgtccaacc aggagggtca ctccgcttgt cctgcgcagc ttctggtttc actttttcaa      540

gctatgcgat gagctgggtg cgccaggccc ctgggaaagg gttggaatgg gtcagcacga      600

tacaaaaaca agggcttcca actcaatatg cagacagcgt gaaaggacgg tttacaattt      660

cacgagacaa tagcaaaaat acgttgtatt tgcaaatgaa ttcactgcga gcggaagaca      720

cagcagtcta ttattgtgca aagaataggg ccaagtttga ttactggggt caagggacgc      780

tcgttaccgt tagcagtggt ggaggagggt ctgggggcgg cggtagcggg ggaggcggaa      840

gtgacatcca gatgacacaa agtccttcat ccctgagcgc aagtgttggg gatcgcgtta      900

ccattacctg ccgcgcttcc caaagtatct cttcttatct caactggtat caacaaaaac      960

cgggcaaagc gcctaagttg ttgatctacg cagcgtcaat gctccaaagc ggtgttccaa     1020

gcagattctc cggcagtggc tcagggacgg actttacgct tacgatatct agccttcagc     1080

cggaagactt tgcaacatat tactgccagc agaatcgagg ctttccactt acttttgggc     1140

agggtacgaa agtggaaata aaaggtaccg gaggttccgg tggttccg                  1188


<210>  19
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Ala Ile Gly 
        35                  40                  45              


Met Lys Ala Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val Ser Thr Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Met Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Gln Lys Gln 
            180                 185                 190         


Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asn Arg Ala Lys 
225                 230                 235                 240 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            260                 265                 270         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        275                 280                 285             


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
305                 310                 315                 320 


Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            340                 345                 350         


Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu Thr Phe Gly 
        355                 360                 365             


Gln Gly Thr Lys Val Glu Ile Lys 
    370                 375     


<210>  20
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20
cctacgacgt gcccgactac gccaccggta acctgcaaaa cgcctcccgg ggaaggcgcc       60

agcgaagaat gcatcctaac gttagtcaag gctgccaagg aggctgtgca acatgctcag      120

attacaatgg atgtttgtca tgtaagccca gactattttt tgctctggaa gccattggca      180

tgaaggccat tggagtatgt ctctcttcat gtccaagtgg atattatgga actcgatatc      240

cagatataaa taagtgtaca aaatgcaaag ctgactgtga tacctgtgag aacaaaaatg      300

agtgcacaaa atgtaaaagt ggattttact tacaccttgg aaagtgcctt gacaattgcc      360

cagaagggtt ggaagccaac aaccatacta tggagtgtgt cagtattgtg agtaccggag      420

gttcaggggg aagcggaggt tccggtatgg aggtccaact tctcgaaagc ggtggtggtc      480

ttgtccaacc aggagggtca ctccgcttgt cctgcgcagc ttctggtttc actttttcaa      540

gctatgcgat gagctgggtg cgccaggccc ctgggaaagg gttggaatgg gtcagcacga      600

tacaaaaaca agggcttcca actcaatatg cagacagcgt gaaaggacgg tttacaattt      660

cacgagacaa tagcaaaaat acgttgtatt tgcaaatgaa ttcactgcga gcggaagaca      720

cagcagtcta ttattgtgca aagaataggg ccaagtttga ttactggggt caagggacgc      780

tcgttaccgt tagcagtggt ggaggagggt ctgggggcgg cggtagcggg ggaggcggaa      840

gtgacatcca gatgacacaa agtccttcat ccctgagcgc aagtgttggg gatcgcgtta      900

ccattacctg ccgcgcttcc caaagtatct cttcttatct caactggtat caacaaaaac      960

cgggcaaagc gcctaagttg ttgatctacg cagcgtcaat gctccaaagc ggtgttccaa     1020

gcagattctc cggcagtggc tcagggacgg actttacgct tacgatatct agccttcagc     1080

cggaagactt tgcaacatat tactgccagc agaatcgagg ctttccactt acttttgggc     1140

agggtacgaa agtggaaata aaaggtaccg gaggttccgg tggttccg                  1188


<210>  21
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg Met His Pro Asn Val 
1               5                   10                  15      


Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly 
            20                  25                  30          


Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala Leu Glu Ala Ile Gly 
        35                  40                  45              


Met Lys Ala Ile Gly Val Cys Leu Ser Ser Cys Pro Ser Gly Tyr Tyr 
    50                  55                  60                  


Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr Lys Cys Lys Ala Asp 
65                  70                  75                  80  


Cys Asp Thr Cys Glu Asn Lys Asn Glu Cys Thr Lys Cys Lys Ser Gly 
                85                  90                  95      


Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn Cys Pro Glu Gly Leu 
            100                 105                 110         


Glu Ala Asn Asn His Thr Met Glu Cys Val Ser Ile Val Ser Thr Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Met Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Gln Lys Gln 
            180                 185                 190         


Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asn Arg Ala Lys 
225                 230                 235                 240 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            260                 265                 270         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        275                 280                 285             


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
305                 310                 315                 320 


Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            340                 345                 350         


Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu Thr Phe Gly 
        355                 360                 365             


Gln Gly Thr Lys Val Glu Ile Lys 
    370                 375     


<210>  22
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
        35                  40                  45              


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
    50                  55                  60                  


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
65                  70                  75                  80  


Ser Ser Arg Leu His Thr Cys Gln Arg His 
                85                  90  


<210>  23
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg 
        35                  40                  45              


Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala 
    50                  55                  60                  


Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys 
65                  70                  75                  80  


Ala Arg Leu His Val Cys Gln Lys 
                85              


<210>  24
<211>  311
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val 
1               5                   10                  15      


Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala Glu Tyr Pro Tyr 
            20                  25                  30          


Asp Val Pro Asp Tyr Ala Thr Gly Glu Val Gln Leu Leu Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Gln Lys Gln Gly Leu 
                85                  90                  95      


Pro Thr Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        115                 120                 125             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asn Arg Ala Lys Phe Asp 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                165                 170                 175     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            180                 185                 190         


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Met 
    210                 215                 220                 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                245                 250                 255     


Tyr Tyr Cys Gln Gln Asn Arg Gly Phe Pro Leu Thr Phe Gly Gln Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Gly Thr Gly Gly Ser Gly Gly Ser Gly Leu 
        275                 280                 285             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Arg Thr Glu 
    290                 295                 300                 


Thr Ser Gln Val Ala Pro Ala 
305                 310     


<210>  25
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val 
1               5                   10                  15      


Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala Glu Tyr Pro Tyr 
            20                  25                  30          


Asp Val Pro Asp Tyr Ala Thr Gly Lys Met Tyr His Thr Lys Gly Gln 
        35                  40                  45              


Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly Leu Cys 
    50                  55                  60                  


Cys Ala Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu 
65                  70                  75                  80  


Gly Gln Val Cys Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu 
                85                  90                  95      


Ile Phe Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg Ile Gln 
            100                 105                 110         


Lys Asp His His Gln Ala Ser Asn Ser Ser Arg Leu His Thr Cys Gln 
        115                 120                 125             


Arg His Gly Thr Gly Gly Ser Gly Gly Ser Gly Leu Asn Asp Ile Phe 
    130                 135                 140                 


Glu Ala Gln Lys Ile Glu Trp His Glu Arg Thr Glu Thr Ser Gln Val 
145                 150                 155                 160 


Ala Pro Ala 
            


<210>  26
<211>  414
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val 
1               5                   10                  15      


Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala Glu Tyr Pro Tyr 
            20                  25                  30          


Asp Val Pro Asp Tyr Ala Thr Gly Lys Met Tyr His Thr Lys Gly Gln 
        35                  40                  45              


Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly Leu Cys 
    50                  55                  60                  


Cys Ala Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu 
65                  70                  75                  80  


Gly Gln Val Cys Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu 
                85                  90                  95      


Ile Phe Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg Ile Gln 
            100                 105                 110         


Lys Asp His His Gln Ala Ser Asn Ser Ser Arg Leu His Thr Cys Gln 
        115                 120                 125             


Arg His Ser Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Met Glu 
    130                 135                 140                 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 
                165                 170                 175     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            180                 185                 190         


Thr Ile Gln Lys Gln Gly Leu Pro Thr Gln Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys Asn Arg Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
        275                 280                 285             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
    290                 295                 300                 


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
305                 310                 315                 320 


Leu Ile Tyr Ala Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            340                 345                 350         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Arg Gly Phe 
        355                 360                 365             


Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Thr Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
385                 390                 395                 400 


Glu Trp His Glu Arg Thr Glu Thr Ser Gln Val Ala Pro Ala 
                405                 410                 


<210>  27
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Ala Lys Asn Arg Ala Lys Phe Asp Tyr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   


