                         SEQUENCE LISTING

<110>  VANDERBILT UNIVERSITY
 
<120>  RECOMBINANT VACCINES AND METHODS OF USE THEREOF

<130>  10644-096WO1

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  5034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
atgcccatgg gcagcctgca gcccctggcc accctgtacc tgctgggcat gctggtggct       60

agcgtgctgg ccgccgaaaa cctgtgggtc accgtgtatt atggagtgcc cgtctggaaa      120

gatgctgaaa ctaccctgtt ctgtgcctct gatgctaagg cctacgagac cgaaaagcac      180

aatgtctggg ctactcatgc atgcgtgccc accgacccaa acccccagga gatccacctg      240

gaaaatgtga ccgaggaatt caacatgtgg aaaaacaata tggtggagca gatgcataca      300

gacatcatta gcctgtggga tcagtccctg aagccctgcg tcaaactgac tcctctgtgc      360

gtgaccctgc agtgtaccaa tgtcacaaac aatatcaccg acgatatgag gggcgagctg      420

aagaattgta gcttcaacat gaccacagaa ctgagagaca agaaacagaa agtgtactcc      480

ctgttttata ggctggatgt ggtccagatc aatgagaacc aggggaatcg gagcaacaat      540

tccaacaagg aatacagact gatcaattgc aacacttccg ccattaccca ggcttgtcct      600

aaagtgtctt ttgagcctat cccaattcat tattgcgccc cagctggctt cgccatcctg      660

aagtgtaaag ataagaagtt caacggaact ggcccctgcc cttccgtgtc tacagtccag      720

tgtactcacg ggattaagcc tgtggtctct acacagctgc tgctgaatgg aagtctggct      780

gaggaagaag tgatgatccg gagcgagaac attaccaaca atgccaagaa tatcctggtc      840

cagttcaaca caccagtgca gattaattgc acaagaccca acaataacac tcgaaaatct      900

atccggattg ggccaggaca ggccttttac gctacagggg acatcattgg agatatcaga      960

caggctcact gtaccgtgag taaggcaacc tggaacgaga cactgggcaa ggtggtcaaa     1020

cagctgagga aacatttcgg gaataacacc atcattcgct ttgccaatag ctccggaggg     1080

gacctggagg tcactaccca ctccttcaac tgcggaggcg aattctttta ctgtaacaca     1140

tctggcctgt ttaatagtac atggatctct aacactagtg tgcagggcag taattcaact     1200

gggtcaaacg atagcatcac cctgccatgc cgaattaagc agatcattaa tatgtggcag     1260

cggatcggcc aggcaatgta tgccccccct atccaggggg tcattcgctg cgtgagcaat     1320

atcaccggac tgattctgac acgagacggg ggcagcacca actctacaac tgaaacattc     1380

cggcccggcg ggggagacat gagagataac tggaggtccg agctgtacaa gtataaagtg     1440

gtcaagatcg aacctctggg agtggcacca accagatgca agcgaagagt ggtcggaggc     1500

ggcagcggcg gcggcggctc cggcggcggc ggctctggcg gcgcagtcgg aattggggcc     1560

gtgttcctgg gatttctggg cgccgctggg agtacaatgg gagcagcctc aatgactctg     1620

accgtgcagg ccaggaatct gctgagcggc atcgtccagc agcagtccaa cctgctgcgc     1680

gctcctgaag cacagcagca cctgctgaag ctgaccgtgt ggggcatcaa acagctgcag     1740

gctagggtgc tggcagtcga gcggtacctg agagaccagc agctgctggg aatctggggc     1800

tgctctggga agctgatttg ttgcacaaat gtgccttgga actctagttg gtcaaatcgc     1860

aacctgagcg agatctggga caatatgact tggctgcagt gggataaaga aattagtaac     1920

tacacccaga tcatctacgg cctgctggaa gagtcacaga atcagcagga gaagaacgaa     1980

caggacctgc tggcactgga tggcagcggc gatatcatca agctgctgaa cgagcaagtg     2040

aataaggaga tgcagagctc caacctgtac atgagcatgt ctagctggtg ctatacccac     2100

tccctggacg gagcaggact gttcctgttt gatcacgccg ccgaggagta tgagcacgcc     2160

aagaagctga tcatctttct gaatgagaac aatgtgcccg tgcagctgac ctccatctct     2220

gcccctgagc acaagttcga gggcctgaca cagatctttc agaaggccta cgagcacgag     2280

cagcacatca gcgagtccat caacaatatc gtggaccacg ccatcaagtc caaggatcac     2340

gccacattca actttctgca gtggtacgtg gccgagcagc acgaggagga ggtgctgttc     2400

aaggacatcc tggataagat cgagctgatc ggcaacgaga atcacggcct gtacctggcc     2460

gaccagtatg tgaagggcat cgccaagtct cggaagagcg gaagcggagc tactaacttc     2520

agcctgctga agcaggctgg agacgtggag gagaaccctg gacctggaag cggaatgccc     2580

atgggcagcc tgcagcccct ggccaccctg tacctgctgg gcatgctggt ggctagcgtg     2640

ctggccgtgg gcaacatgtg ggtgacagtg tactatggcg tgcccgtgtg gaccgatgcc     2700

aagaccacac tgttctgcgc ctccgacaca aaggcctacg atcgggaggt gcacaacgtg     2760

tgggcaacac acgcatgcgt gccaaccgac ccaaatcccc aggagatcgt gctggagaac     2820

gtgaccgaga acttcaacat gtggaagaac gacatggtgg atcagatgca cgaggacatc     2880

atcagcctgt gggatcagtc cctgaagcca tgcgtgaagc tgacacccct gtgcgtgacc     2940

ctgcactgta caaacgccac ctttaagaac aatgtgacca atgatatgaa caaggagatc     3000

aggaattgtt ctttcaacac cacaaccgag atccgcgata agaagcagca gggctacgcc     3060

ctgttttata ggcctgacat cgtgctgctg aaggagaatc gcaacaattc taacaatagc     3120

gagtatatcc tgatcaattg caacgccagc acaatcaccc aggcctgtcc caaggtgaac     3180

ttcgacccta tcccaatcca ctactgcgcc cctgccggct atgccatcct gaagtgtaac     3240

aacaagacct tcagcggcaa gggcccatgc aacaacgtga gcacagtgca gtgtacccac     3300

ggcatcaagc ccgtggtgtc cacccagctg ctgctgaatg gctctctggc cgagaaggag     3360

atcatcatca ggtccgagaa tctgacagat aacgtgaaga ccatcatcgt gcacctgaac     3420

aagtccgtgg agatcgtgtg cacacgccct aacaataaca ccaggaagtc tatgcgcatc     3480

ggcccaggcc agacattcta cgccaccggc gacatcatcg gcgatatccg gcaggcctat     3540

tgtaatatca gcggctccaa gtggaacgag acactgaaga gagtgaagga gaagctgcag     3600

gagaactaca ataacaataa gaccatcaag ttcgcaccaa gctccggagg cgatctggag     3660

atcacaaccc acagctttaa ttgccggggc gagttctttt attgtaacac aaccagactg     3720

ttcaacaata acgccaccga ggacgagaca atcaccctgc cttgccggat caagcagatc     3780

atcaatatgt ggcagggagt gggaagagca atgtacgcac cacctatcgc cggcaatatc     3840

acctgtaaga gcaacatcac cggactgctg ctggtgagag acggaggaga ggataacaag     3900

acagaggaga tctttcggcc cggcggcggc aatatgaagg acaactggag atccgagctg     3960

tacaagtata aagtgatcga gctgaagcca ctgggaatcg cacctaccgg atgcaagagg     4020

agagtggtgg agggaggctc tggaggagga ggaagcggag gaggaggatc cggcggcgcc     4080

gtgggcatcg gagccgtgtt cctgggcttt ctgggagcag caggatctac catgggagca     4140

gcaagcctga cactgaccgt gcaggccagg cagctgctgt ctagcatcgt gcagcagcag     4200

tccaatctgc tgagggcacc agaggcacag cagcacatgc tgcagctgac agtgtggggc     4260

atcaagcagc tgcagacccg ggtgctggcc atcgagagat acctgaagga tcagcagctg     4320

ctgggcatct ggggctgctc tggcaagctg atctgctgta ccaatgtgcc ctggaactcc     4380

tcttggtcca acaagtctca gacagacatc tggaataaca tgacctggat ggagtgggac     4440

agggagatct ctaattacac agataccatc tatcgcctgc tggaggacag ccagacccag     4500

caggagaaga acgagaagga cctgctggcc ctggatggaa gcggagatat catcaagctg     4560

ctgaacgagc aagtgaataa ggagatgcag agctccaacc tgtacatgag catgtctagc     4620

tggtgctata cccactccct ggacggagca ggactgttcc tgtttgatca cgccgccgag     4680

gagtatgagc acgccaagaa gctgatcatc tttctgaatg agaacaatgt gcccgtgcag     4740

ctgacctcca tctctgcccc tgagcacaag ttcgagggcc tgacacagat ctttcagaag     4800

gcctacgagc acgagcagca catcagcgag tccatcaaca atatcgtgga ccacgccatc     4860

aagtccaagg atcacgccac attcaacttt ctgcagtggt acgtggccga gcagcacgag     4920

gaggaggtgc tgttcaagga catcctggat aagatcgagc tgatcggcaa cgagaatcac     4980

ggcctgtacc tggccgacca gtatgtgaag ggcatcgcca agtctcggaa gagc           5034


<210>  2
<211>  1678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Gln Cys Thr Asn Val 
        115                 120                 125             


Thr Asn Asn Ile Thr Asp Asp Met Arg Gly Glu Leu Lys Asn Cys Ser 
    130                 135                 140                 


Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ser 
145                 150                 155                 160 


Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu Asn Gln Gly Asn 
                165                 170                 175     


Arg Ser Asn Asn Ser Asn Lys Glu Tyr Arg Leu Ile Asn Cys Asn Thr 
            180                 185                 190         


Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro 
        195                 200                 205             


Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
    210                 215                 220                 


Lys Lys Phe Asn Gly Thr Gly Pro Cys Pro Ser Val Ser Thr Val Gln 
225                 230                 235                 240 


Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
                245                 250                 255     


Gly Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr 
            260                 265                 270         


Asn Asn Ala Lys Asn Ile Leu Val Gln Phe Asn Thr Pro Val Gln Ile 
        275                 280                 285             


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly 
    290                 295                 300                 


Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg 
305                 310                 315                 320 


Gln Ala His Cys Thr Val Ser Lys Ala Thr Trp Asn Glu Thr Leu Gly 
                325                 330                 335     


Lys Val Val Lys Gln Leu Arg Lys His Phe Gly Asn Asn Thr Ile Ile 
            340                 345                 350         


Arg Phe Ala Asn Ser Ser Gly Gly Asp Leu Glu Val Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Ser Thr Trp Ile Ser Asn Thr Ser Val Gln Gly Ser Asn Ser Thr 
385                 390                 395                 400 


Gly Ser Asn Asp Ser Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Arg Ile Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln 
            420                 425                 430         


Gly Val Ile Arg Cys Val Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Ser Thr Asn Ser Thr Thr Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg 
                485                 490                 495     


Val Val Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Asn Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn 
625                 630                 635                 640 


Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Ser Gly Asp Ile 
            660                 665                 670         


Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
        675                 680                 685             


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
    690                 695                 700                 


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
705                 710                 715                 720 


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
                725                 730                 735     


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
            740                 745                 750         


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
        755                 760                 765             


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
    770                 775                 780                 


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
785                 790                 795                 800 


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
                805                 810                 815     


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
            820                 825                 830         


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        835                 840                 845             


Val Glu Glu Asn Pro Gly Pro Gly Ser Gly Met Pro Met Gly Ser Leu 
    850                 855                 860                 


Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu Val Ala Ser Val 
865                 870                 875                 880 


Leu Ala Val Gly Asn Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
                885                 890                 895     


Trp Thr Asp Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Thr Lys Ala 
            900                 905                 910         


Tyr Asp Arg Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        915                 920                 925             


Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    930                 935                 940                 


Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile 
945                 950                 955                 960 


Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                965                 970                 975     


Leu Cys Val Thr Leu His Cys Thr Asn Ala Thr Phe Lys Asn Asn Val 
            980                 985                 990         


Thr Asn Asp Met Asn Lys Glu Ile  Arg Asn Cys Ser Phe  Asn Thr Thr 
        995                 1000                 1005             


Thr Glu  Ile Arg Asp Lys Lys  Gln Gln Gly Tyr Ala  Leu Phe Tyr 
    1010                 1015                 1020             


Arg Pro  Asp Ile Val Leu Leu  Lys Glu Asn Arg Asn  Asn Ser Asn 
    1025                 1030                 1035             


Asn Ser  Glu Tyr Ile Leu Ile  Asn Cys Asn Ala Ser  Thr Ile Thr 
    1040                 1045                 1050             


Gln Ala  Cys Pro Lys Val Asn  Phe Asp Pro Ile Pro  Ile His Tyr 
    1055                 1060                 1065             


Cys Ala  Pro Ala Gly Tyr Ala  Ile Leu Lys Cys Asn  Asn Lys Thr 
    1070                 1075                 1080             


Phe Ser  Gly Lys Gly Pro Cys  Asn Asn Val Ser Thr  Val Gln Cys 
    1085                 1090                 1095             


Thr His  Gly Ile Lys Pro Val  Val Ser Thr Gln Leu  Leu Leu Asn 
    1100                 1105                 1110             


Gly Ser  Leu Ala Glu Lys Glu  Ile Ile Ile Arg Ser  Glu Asn Leu 
    1115                 1120                 1125             


Thr Asp  Asn Val Lys Thr Ile  Ile Val His Leu Asn  Lys Ser Val 
    1130                 1135                 1140             


Glu Ile  Val Cys Thr Arg Pro  Asn Asn Asn Thr Arg  Lys Ser Met 
    1145                 1150                 1155             


Arg Ile  Gly Pro Gly Gln Thr  Phe Tyr Ala Thr Gly  Asp Ile Ile 
    1160                 1165                 1170             


Gly Asp  Ile Arg Gln Ala Tyr  Cys Asn Ile Ser Gly  Ser Lys Trp 
    1175                 1180                 1185             


Asn Glu  Thr Leu Lys Arg Val  Lys Glu Lys Leu Gln  Glu Asn Tyr 
    1190                 1195                 1200             


Asn Asn  Asn Lys Thr Ile Lys  Phe Ala Pro Ser Ser  Gly Gly Asp 
    1205                 1210                 1215             


Leu Glu  Ile Thr Thr His Ser  Phe Asn Cys Arg Gly  Glu Phe Phe 
    1220                 1225                 1230             


Tyr Cys  Asn Thr Thr Arg Leu  Phe Asn Asn Asn Ala  Thr Glu Asp 
    1235                 1240                 1245             


Glu Thr  Ile Thr Leu Pro Cys  Arg Ile Lys Gln Ile  Ile Asn Met 
    1250                 1255                 1260             


Trp Gln  Gly Val Gly Arg Ala  Met Tyr Ala Pro Pro  Ile Ala Gly 
    1265                 1270                 1275             


Asn Ile  Thr Cys Lys Ser Asn  Ile Thr Gly Leu Leu  Leu Val Arg 
    1280                 1285                 1290             


Asp Gly  Gly Glu Asp Asn Lys  Thr Glu Glu Ile Phe  Arg Pro Gly 
    1295                 1300                 1305             


Gly Gly  Asn Met Lys Asp Asn  Trp Arg Ser Glu Leu  Tyr Lys Tyr 
    1310                 1315                 1320             


Lys Val  Ile Glu Leu Lys Pro  Leu Gly Ile Ala Pro  Thr Gly Cys 
    1325                 1330                 1335             


Lys Arg  Arg Val Val Glu Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1340                 1345                 1350             


Gly Gly  Gly Ser Gly Gly Ala  Val Gly Ile Gly Ala  Val Phe Leu 
    1355                 1360                 1365             


Gly Phe  Leu Gly Ala Ala Gly  Ser Thr Met Gly Ala  Ala Ser Leu 
    1370                 1375                 1380             


Thr Leu  Thr Val Gln Ala Arg  Gln Leu Leu Ser Ser  Ile Val Gln 
    1385                 1390                 1395             


Gln Gln  Ser Asn Leu Leu Arg  Ala Pro Glu Ala Gln  Gln His Met 
    1400                 1405                 1410             


Leu Gln  Leu Thr Val Trp Gly  Ile Lys Gln Leu Gln  Thr Arg Val 
    1415                 1420                 1425             


Leu Ala  Ile Glu Arg Tyr Leu  Lys Asp Gln Gln Leu  Leu Gly Ile 
    1430                 1435                 1440             


Trp Gly  Cys Ser Gly Lys Leu  Ile Cys Cys Thr Asn  Val Pro Trp 
    1445                 1450                 1455             


Asn Ser  Ser Trp Ser Asn Lys  Ser Gln Thr Asp Ile  Trp Asn Asn 
    1460                 1465                 1470             


Met Thr  Trp Met Glu Trp Asp  Arg Glu Ile Ser Asn  Tyr Thr Asp 
    1475                 1480                 1485             


Thr Ile  Tyr Arg Leu Leu Glu  Asp Ser Gln Thr Gln  Gln Glu Lys 
    1490                 1495                 1500             


Asn Glu  Lys Asp Leu Leu Ala  Leu Asp Gly Ser Gly  Asp Ile Ile 
    1505                 1510                 1515             


Lys Leu  Leu Asn Glu Gln Val  Asn Lys Glu Met Gln  Ser Ser Asn 
    1520                 1525                 1530             


Leu Tyr  Met Ser Met Ser Ser  Trp Cys Tyr Thr His  Ser Leu Asp 
    1535                 1540                 1545             


Gly Ala  Gly Leu Phe Leu Phe  Asp His Ala Ala Glu  Glu Tyr Glu 
    1550                 1555                 1560             


His Ala  Lys Lys Leu Ile Ile  Phe Leu Asn Glu Asn  Asn Val Pro 
    1565                 1570                 1575             


Val Gln  Leu Thr Ser Ile Ser  Ala Pro Glu His Lys  Phe Glu Gly 
    1580                 1585                 1590             


Leu Thr  Gln Ile Phe Gln Lys  Ala Tyr Glu His Glu  Gln His Ile 
    1595                 1600                 1605             


Ser Glu  Ser Ile Asn Asn Ile  Val Asp His Ala Ile  Lys Ser Lys 
    1610                 1615                 1620             


Asp His  Ala Thr Phe Asn Phe  Leu Gln Trp Tyr Val  Ala Glu Gln 
    1625                 1630                 1635             


His Glu  Glu Glu Val Leu Phe  Lys Asp Ile Leu Asp  Lys Ile Glu 
    1640                 1645                 1650             


Leu Ile  Gly Asn Glu Asn His  Gly Leu Tyr Leu Ala  Asp Gln Tyr 
    1655                 1660                 1665             


Val Lys  Gly Ile Ala Lys Ser  Arg Lys Ser 
    1670                 1675             


<210>  3
<211>  4041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
atgcccatgg gcagcctgca gcccctggcc accctgtacc tgctgggcat gctggtggct       60

agcgtgctgg ccgccgaaaa cctgtgggtc accgtgtatt atggagtgcc cgtctggaaa      120

gatgctgaaa ctaccctgtt ctgtgcctct gatgctaagg cctacgagac cgaaaagcac      180

aatgtctggg ctactcatgc atgcgtgccc accgacccaa acccccagga gatccacctg      240

gaaaatgtga ccgaggaatt caacatgtgg aaaaacaata tggtggagca gatgcataca      300

gacatcatta gcctgtggga tcagtccctg aagccctgcg tcaaactgac tcctctgtgc      360

gtgaccctgc agtgtaccaa tgtcacaaac aatatcaccg acgatatgag gggcgagctg      420

aagaattgta gcttcaacat gaccacagaa ctgagagaca agaaacagaa agtgtactcc      480

ctgttttata ggctggatgt ggtccagatc aatgagaacc aggggaatcg gagcaacaat      540

tccaacaagg aatacagact gatcaattgc aacacttccg ccattaccca ggcttgtcct      600

aaagtgtctt ttgagcctat cccaattcat tattgcgccc cagctggctt cgccatcctg      660

aagtgtaaag ataagaagtt caacggaact ggcccctgcc cttccgtgtc tacagtccag      720

tgtactcacg ggattaagcc tgtggtctct acacagctgc tgctgaatgg aagtctggct      780

gaggaagaag tgatgatccg gagcgagaac attaccaaca atgccaagaa tatcctggtc      840

cagttcaaca caccagtgca gattaattgc acaagaccca acaataacac tcgaaaatct      900

atccggattg ggccaggaca ggccttttac gctacagggg acatcattgg agatatcaga      960

caggctcact gtaccgtgag taaggcaacc tggaacgaga cactgggcaa ggtggtcaaa     1020

cagctgagga aacatttcgg gaataacacc atcattcgct ttgccaatag ctccggaggg     1080

gacctggagg tcactaccca ctccttcaac tgcggaggcg aattctttta ctgtaacaca     1140

tctggcctgt ttaatagtac atggatctct aacactagtg tgcagggcag taattcaact     1200

gggtcaaacg atagcatcac cctgccatgc cgaattaagc agatcattaa tatgtggcag     1260

cggatcggcc aggcaatgta tgccccccct atccaggggg tcattcgctg cgtgagcaat     1320

atcaccggac tgattctgac acgagacggg ggcagcacca actctacaac tgaaacattc     1380

cggcccggcg ggggagacat gagagataac tggaggtccg agctgtacaa gtataaagtg     1440

gtcaagatcg aacctctggg agtggcacca accagatgca agcgaagagt ggtcggaggc     1500

ggcagcggcg gcggcggctc cggcggcggc ggctctggcg gcgcagtcgg aattggggcc     1560

gtgttcctgg gatttctggg cgccgctggg agtacaatgg gagcagcctc aatgactctg     1620

accgtgcagg ccaggaatct gctgagcggc atcgtccagc agcagtccaa cctgctgcgc     1680

gctcctgaag cacagcagca cctgctgaag ctgaccgtgt ggggcatcaa acagctgcag     1740

gctagggtgc tggcagtcga gcggtacctg agagaccagc agctgctggg aatctggggc     1800

tgctctggga agctgatttg ttgcacaaat gtgccttgga actctagttg gtcaaatcgc     1860

aacctgagcg agatctggga caatatgact tggctgcagt gggataaaga aattagtaac     1920

tacacccaga tcatctacgg cctgctggaa gagtcacaga atcagcagga gaagaacgaa     1980

caggacctgc tggcactgga tggcagcggc gctactaact tcagcctgct gaagcaggct     2040

ggagacgtgg aggagaaccc tggacctgga agcggaatgc ccatgggcag cctgcagccc     2100

ctggccaccc tgtacctgct gggcatgctg gtggctagcg tgctggccgt gggcaacatg     2160

tgggtgacag tgtactatgg cgtgcccgtg tggaccgatg ccaagaccac actgttctgc     2220

gcctccgaca caaaggccta cgatcgggag gtgcacaacg tgtgggcaac acacgcatgc     2280

gtgccaaccg acccaaatcc ccaggagatc gtgctggaga acgtgaccga gaacttcaac     2340

atgtggaaga acgacatggt ggatcagatg cacgaggaca tcatcagcct gtgggatcag     2400

tccctgaagc catgcgtgaa gctgacaccc ctgtgcgtga ccctgcactg tacaaacgcc     2460

acctttaaga acaatgtgac caatgatatg aacaaggaga tcaggaattg ttctttcaac     2520

accacaaccg agatccgcga taagaagcag cagggctacg ccctgtttta taggcctgac     2580

atcgtgctgc tgaaggagaa tcgcaacaat tctaacaata gcgagtatat cctgatcaat     2640

tgcaacgcca gcacaatcac ccaggcctgt cccaaggtga acttcgaccc tatcccaatc     2700

cactactgcg cccctgccgg ctatgccatc ctgaagtgta acaacaagac cttcagcggc     2760

aagggcccat gcaacaacgt gagcacagtg cagtgtaccc acggcatcaa gcccgtggtg     2820

tccacccagc tgctgctgaa tggctctctg gccgagaagg agatcatcat caggtccgag     2880

aatctgacag ataacgtgaa gaccatcatc gtgcacctga acaagtccgt ggagatcgtg     2940

tgcacacgcc ctaacaataa caccaggaag tctatgcgca tcggcccagg ccagacattc     3000

tacgccaccg gcgacatcat cggcgatatc cggcaggcct attgtaatat cagcggctcc     3060

aagtggaacg agacactgaa gagagtgaag gagaagctgc aggagaacta caataacaat     3120

aagaccatca agttcgcacc aagctccgga ggcgatctgg agatcacaac ccacagcttt     3180

aattgccggg gcgagttctt ttattgtaac acaaccagac tgttcaacaa taacgccacc     3240

gaggacgaga caatcaccct gccttgccgg atcaagcaga tcatcaatat gtggcaggga     3300

gtgggaagag caatgtacgc accacctatc gccggcaata tcacctgtaa gagcaacatc     3360

accggactgc tgctggtgag agacggagga gaggataaca agacagagga gatctttcgg     3420

cccggcggcg gcaatatgaa ggacaactgg agatccgagc tgtacaagta taaagtgatc     3480

gagctgaagc cactgggaat cgcacctacc ggatgcaaga ggagagtggt ggagggaggc     3540

tctggaggag gaggaagcgg aggaggagga tccggcggcg ccgtgggcat cggagccgtg     3600

ttcctgggct ttctgggagc agcaggatct accatgggag cagcaagcct gacactgacc     3660

gtgcaggcca ggcagctgct gtctagcatc gtgcagcagc agtccaatct gctgagggca     3720

ccagaggcac agcagcacat gctgcagctg acagtgtggg gcatcaagca gctgcagacc     3780

cgggtgctgg ccatcgagag atacctgaag gatcagcagc tgctgggcat ctggggctgc     3840

tctggcaagc tgatctgctg taccaatgtg ccctggaact cctcttggtc caacaagtct     3900

cagacagaca tctggaataa catgacctgg atggagtggg acagggagat ctctaattac     3960

acagatacca tctatcgcct gctggaggac agccagaccc agcaggagaa gaacgagaag     4020

gacctgctgg ccctggattg a                                               4041


<210>  4
<211>  1349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Gln Cys Thr Asn Val 
        115                 120                 125             


Thr Asn Asn Ile Thr Asp Asp Met Arg Gly Glu Leu Lys Asn Cys Ser 
    130                 135                 140                 


Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ser 
145                 150                 155                 160 


Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu Asn Gln Gly Asn 
                165                 170                 175     


Arg Ser Asn Asn Ser Asn Lys Glu Tyr Arg Leu Ile Asn Cys Asn Thr 
            180                 185                 190         


Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro 
        195                 200                 205             


Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
    210                 215                 220                 


Lys Lys Phe Asn Gly Thr Gly Pro Cys Pro Ser Val Ser Thr Val Gln 
225                 230                 235                 240 


Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
                245                 250                 255     


Gly Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr 
            260                 265                 270         


Asn Asn Ala Lys Asn Ile Leu Val Gln Phe Asn Thr Pro Val Gln Ile 
        275                 280                 285             


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly 
    290                 295                 300                 


Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg 
305                 310                 315                 320 


Gln Ala His Cys Thr Val Ser Lys Ala Thr Trp Asn Glu Thr Leu Gly 
                325                 330                 335     


Lys Val Val Lys Gln Leu Arg Lys His Phe Gly Asn Asn Thr Ile Ile 
            340                 345                 350         


Arg Phe Ala Asn Ser Ser Gly Gly Asp Leu Glu Val Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Ser Thr Trp Ile Ser Asn Thr Ser Val Gln Gly Ser Asn Ser Thr 
385                 390                 395                 400 


Gly Ser Asn Asp Ser Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Arg Ile Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln 
            420                 425                 430         


Gly Val Ile Arg Cys Val Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Ser Thr Asn Ser Thr Thr Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg 
                485                 490                 495     


Val Val Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Asn Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn 
625                 630                 635                 640 


Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Ser Gly Gly Ser 
            660                 665                 670         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        675                 680                 685             


Asn Pro Gly Pro Gly Ser Gly Met Pro Met Gly Ser Leu Gln Pro Leu 
    690                 695                 700                 


Ala Thr Leu Tyr Leu Leu Gly Met Leu Val Ala Ser Val Leu Ala Val 
705                 710                 715                 720 


Gly Asn Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Asp 
                725                 730                 735     


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Thr Lys Ala Tyr Asp Arg 
            740                 745                 750         


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
        755                 760                 765             


Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
    770                 775                 780                 


Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu 
785                 790                 795                 800 


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
                805                 810                 815     


Thr Leu His Cys Thr Asn Ala Thr Phe Lys Asn Asn Val Thr Asn Asp 
            820                 825                 830         


Met Asn Lys Glu Ile Arg Asn Cys Ser Phe Asn Thr Thr Thr Glu Ile 
        835                 840                 845             


Arg Asp Lys Lys Gln Gln Gly Tyr Ala Leu Phe Tyr Arg Pro Asp Ile 
    850                 855                 860                 


Val Leu Leu Lys Glu Asn Arg Asn Asn Ser Asn Asn Ser Glu Tyr Ile 
865                 870                 875                 880 


Leu Ile Asn Cys Asn Ala Ser Thr Ile Thr Gln Ala Cys Pro Lys Val 
                885                 890                 895     


Asn Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala 
            900                 905                 910         


Ile Leu Lys Cys Asn Asn Lys Thr Phe Ser Gly Lys Gly Pro Cys Asn 
        915                 920                 925             


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser 
    930                 935                 940                 


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile Ile Ile 
945                 950                 955                 960 


Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile Val His Leu 
                965                 970                 975     


Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg 
            980                 985                 990         


Lys Ser Met Arg Ile Gly Pro Gly  Gln Thr Phe Tyr Ala  Thr Gly Asp 
        995                 1000                 1005             


Ile Ile  Gly Asp Ile Arg Gln  Ala Tyr Cys Asn Ile  Ser Gly Ser 
    1010                 1015                 1020             


Lys Trp  Asn Glu Thr Leu Lys  Arg Val Lys Glu Lys  Leu Gln Glu 
    1025                 1030                 1035             


Asn Tyr  Asn Asn Asn Lys Thr  Ile Lys Phe Ala Pro  Ser Ser Gly 
    1040                 1045                 1050             


Gly Asp  Leu Glu Ile Thr Thr  His Ser Phe Asn Cys  Arg Gly Glu 
    1055                 1060                 1065             


Phe Phe  Tyr Cys Asn Thr Thr  Arg Leu Phe Asn Asn  Asn Ala Thr 
    1070                 1075                 1080             


Glu Asp  Glu Thr Ile Thr Leu  Pro Cys Arg Ile Lys  Gln Ile Ile 
    1085                 1090                 1095             


Asn Met  Trp Gln Gly Val Gly  Arg Ala Met Tyr Ala  Pro Pro Ile 
    1100                 1105                 1110             


Ala Gly  Asn Ile Thr Cys Lys  Ser Asn Ile Thr Gly  Leu Leu Leu 
    1115                 1120                 1125             


Val Arg  Asp Gly Gly Glu Asp  Asn Lys Thr Glu Glu  Ile Phe Arg 
    1130                 1135                 1140             


Pro Gly  Gly Gly Asn Met Lys  Asp Asn Trp Arg Ser  Glu Leu Tyr 
    1145                 1150                 1155             


Lys Tyr  Lys Val Ile Glu Leu  Lys Pro Leu Gly Ile  Ala Pro Thr 
    1160                 1165                 1170             


Gly Cys  Lys Arg Arg Val Val  Glu Gly Gly Ser Gly  Gly Gly Gly 
    1175                 1180                 1185             


Ser Gly  Gly Gly Gly Ser Gly  Gly Ala Val Gly Ile  Gly Ala Val 
    1190                 1195                 1200             


Phe Leu  Gly Phe Leu Gly Ala  Ala Gly Ser Thr Met  Gly Ala Ala 
    1205                 1210                 1215             


Ser Leu  Thr Leu Thr Val Gln  Ala Arg Gln Leu Leu  Ser Ser Ile 
    1220                 1225                 1230             


Val Gln  Gln Gln Ser Asn Leu  Leu Arg Ala Pro Glu  Ala Gln Gln 
    1235                 1240                 1245             


His Met  Leu Gln Leu Thr Val  Trp Gly Ile Lys Gln  Leu Gln Thr 
    1250                 1255                 1260             


Arg Val  Leu Ala Ile Glu Arg  Tyr Leu Lys Asp Gln  Gln Leu Leu 
    1265                 1270                 1275             


Gly Ile  Trp Gly Cys Ser Gly  Lys Leu Ile Cys Cys  Thr Asn Val 
    1280                 1285                 1290             


Pro Trp  Asn Ser Ser Trp Ser  Asn Lys Ser Gln Thr  Asp Ile Trp 
    1295                 1300                 1305             


Asn Asn  Met Thr Trp Met Glu  Trp Asp Arg Glu Ile  Ser Asn Tyr 
    1310                 1315                 1320             


Thr Asp  Thr Ile Tyr Arg Leu  Leu Glu Asp Ser Gln  Thr Gln Gln 
    1325                 1330                 1335             


Glu Lys  Asn Glu Lys Asp Leu  Leu Ala Leu Asp 
    1340                 1345                 


<210>  5
<211>  1929
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
gccgaaaacc tgtgggtcac cgtgtattat ggagtgcccg tctggaaaga tgctgaaact       60

accctgttct gtgcctctga tgctaaggcc tacgagaccg aaaagcacaa tgtctgggct      120

actcatgcat gcgtgcccac cgacccaaac ccccaggaga tccacctgga aaatgtgacc      180

gaggaattca acatgtggaa aaacaatatg gtggagcaga tgcatacaga catcattagc      240

ctgtgggatc agtccctgaa gccctgcgtc aaactgactc ctctgtgcgt gaccctgcag      300

tgtaccaatg tcacaaacaa tatcaccgac gatatgaggg gcgagctgaa gaattgtagc      360

ttcaacatga ccacagaact gagagacaag aaacagaaag tgtactccct gttttatagg      420

ctggatgtgg tccagatcaa tgagaaccag gggaatcgga gcaacaattc caacaaggaa      480

tacagactga tcaattgcaa cacttccgcc attacccagg cttgtcctaa agtgtctttt      540

gagcctatcc caattcatta ttgcgcccca gctggcttcg ccatcctgaa gtgtaaagat      600

aagaagttca acggaactgg cccctgccct tccgtgtcta cagtccagtg tactcacggg      660

attaagcctg tggtctctac acagctgctg ctgaatggaa gtctggctga ggaagaagtg      720

atgatccgga gcgagaacat taccaacaat gccaagaata tcctggtcca gttcaacaca      780

ccagtgcaga ttaattgcac aagacccaac aataacactc gaaaatctat ccggattggg      840

ccaggacagg ccttttacgc tacaggggac atcattggag atatcagaca ggctcactgt      900

accgtgagta aggcaacctg gaacgagaca ctgggcaagg tggtcaaaca gctgaggaaa      960

catttcggga ataacaccat cattcgcttt gccaatagct ccggagggga cctggaggtc     1020

actacccact ccttcaactg cggaggcgaa ttcttttact gtaacacatc tggcctgttt     1080

aatagtacat ggatctctaa cactagtgtg cagggcagta attcaactgg gtcaaacgat     1140

agcatcaccc tgccatgccg aattaagcag atcattaata tgtggcagcg gatcggccag     1200

gcaatgtatg ccccccctat ccagggggtc attcgctgcg tgagcaatat caccggactg     1260

attctgacac gagacggggg cagcaccaac tctacaactg aaacattccg gcccggcggg     1320

ggagacatga gagataactg gaggtccgag ctgtacaagt ataaagtggt caagatcgaa     1380

cctctgggag tggcaccaac cagatgcaag cgaagagtgg tcggaggcgg cagcggcggc     1440

ggcggctccg gcggcggcgg ctctggcggc gcagtcggaa ttggggccgt gttcctggga     1500

tttctgggcg ccgctgggag tacaatggga gcagcctcaa tgactctgac cgtgcaggcc     1560

aggaatctgc tgagcggcat cgtccagcag cagtccaacc tgctgcgcgc tcctgaagca     1620

cagcagcacc tgctgaagct gaccgtgtgg ggcatcaaac agctgcaggc tagggtgctg     1680

gcagtcgagc ggtacctgag agaccagcag ctgctgggaa tctggggctg ctctgggaag     1740

ctgatttgtt gcacaaatgt gccttggaac tctagttggt caaatcgcaa cctgagcgag     1800

atctgggaca atatgacttg gctgcagtgg gataaagaaa ttagtaacta cacccagatc     1860

atctacggcc tgctggaaga gtcacagaat cagcaggaga agaacgaaca ggacctgctg     1920

gcactggat                                                             1929


<210>  6
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Ala Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys 
1               5                   10                  15      


Asp Ala Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu 
            20                  25                  30          


Thr Glu Lys His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp 
        35                  40                  45              


Pro Asn Pro Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn 
    50                  55                  60                  


Met Trp Lys Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser 
65                  70                  75                  80  


Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys 
                85                  90                  95      


Val Thr Leu Gln Cys Thr Asn Val Thr Asn Asn Ile Thr Asp Asp Met 
            100                 105                 110         


Arg Gly Glu Leu Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg 
        115                 120                 125             


Asp Lys Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val 
    130                 135                 140                 


Gln Ile Asn Glu Asn Gln Gly Asn Arg Ser Asn Asn Ser Asn Lys Glu 
145                 150                 155                 160 


Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro 
                165                 170                 175     


Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
            180                 185                 190         


Phe Ala Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro 
        195                 200                 205             


Cys Pro Ser Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val 
    210                 215                 220                 


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val 
225                 230                 235                 240 


Met Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile Leu Val 
                245                 250                 255     


Gln Phe Asn Thr Pro Val Gln Ile Asn Cys Thr Arg Pro Asn Asn Asn 
            260                 265                 270         


Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr 
        275                 280                 285             


Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Thr Val Ser Lys 
    290                 295                 300                 


Ala Thr Trp Asn Glu Thr Leu Gly Lys Val Val Lys Gln Leu Arg Lys 
305                 310                 315                 320 


His Phe Gly Asn Asn Thr Ile Ile Arg Phe Ala Asn Ser Ser Gly Gly 
                325                 330                 335     


Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
            340                 345                 350         


Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ile Ser Asn Thr 
        355                 360                 365             


Ser Val Gln Gly Ser Asn Ser Thr Gly Ser Asn Asp Ser Ile Thr Leu 
    370                 375                 380                 


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Ile Gly Gln 
385                 390                 395                 400 


Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Val Ser Asn 
                405                 410                 415     


Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Ser Thr Asn Ser Thr 
            420                 425                 430         


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
        435                 440                 445             


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
    450                 455                 460                 


Ala Pro Thr Arg Cys Lys Arg Arg Val Val Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala 
                485                 490                 495     


Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
            500                 505                 510         


Ser Met Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val 
        515                 520                 525             


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu 
    530                 535                 540                 


Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu 
545                 550                 555                 560 


Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly 
                565                 570                 575     


Cys Ser Gly Lys Leu Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser 
            580                 585                 590         


Trp Ser Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu 
        595                 600                 605             


Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu 
    610                 615                 620                 


Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu 
625                 630                 635                 640 


Ala Leu Asp 
            


<210>  7
<211>  1890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
gtgggcaaca tgtgggtgac agtgtactat ggcgtgcccg tgtggaccga tgccaagacc       60

acactgttct gcgcctccga cacaaaggcc tacgatcggg aggtgcacaa cgtgtgggca      120

acacacgcat gcgtgccaac cgacccaaat ccccaggaga tcgtgctgga gaacgtgacc      180

gagaacttca acatgtggaa gaacgacatg gtggatcaga tgcacgagga catcatcagc      240

ctgtgggatc agtccctgaa gccatgcgtg aagctgacac ccctgtgcgt gaccctgcac      300

tgtacaaacg ccacctttaa gaacaatgtg accaatgata tgaacaagga gatcaggaat      360

tgttctttca acaccacaac cgagatccgc gataagaagc agcagggcta cgccctgttt      420

tataggcctg acatcgtgct gctgaaggag aatcgcaaca attctaacaa tagcgagtat      480

atcctgatca attgcaacgc cagcacaatc acccaggcct gtcccaaggt gaacttcgac      540

cctatcccaa tccactactg cgcccctgcc ggctatgcca tcctgaagtg taacaacaag      600

accttcagcg gcaagggccc atgcaacaac gtgagcacag tgcagtgtac ccacggcatc      660

aagcccgtgg tgtccaccca gctgctgctg aatggctctc tggccgagaa ggagatcatc      720

atcaggtccg agaatctgac agataacgtg aagaccatca tcgtgcacct gaacaagtcc      780

gtggagatcg tgtgcacacg ccctaacaat aacaccagga agtctatgcg catcggccca      840

ggccagacat tctacgccac cggcgacatc atcggcgata tccggcaggc ctattgtaat      900

atcagcggct ccaagtggaa cgagacactg aagagagtga aggagaagct gcaggagaac      960

tacaataaca ataagaccat caagttcgca ccaagctccg gaggcgatct ggagatcaca     1020

acccacagct ttaattgccg gggcgagttc ttttattgta acacaaccag actgttcaac     1080

aataacgcca ccgaggacga gacaatcacc ctgccttgcc ggatcaagca gatcatcaat     1140

atgtggcagg gagtgggaag agcaatgtac gcaccaccta tcgccggcaa tatcacctgt     1200

aagagcaaca tcaccggact gctgctggtg agagacggag gagaggataa caagacagag     1260

gagatctttc ggcccggcgg cggcaatatg aaggacaact ggagatccga gctgtacaag     1320

tataaagtga tcgagctgaa gccactggga atcgcaccta ccggatgcaa gaggagagtg     1380

gtggagggag gctctggagg aggaggaagc ggaggaggag gatccggcgg cgccgtgggc     1440

atcggagccg tgttcctggg ctttctggga gcagcaggat ctaccatggg agcagcaagc     1500

ctgacactga ccgtgcaggc caggcagctg ctgtctagca tcgtgcagca gcagtccaat     1560

ctgctgaggg caccagaggc acagcagcac atgctgcagc tgacagtgtg gggcatcaag     1620

cagctgcaga cccgggtgct ggccatcgag agatacctga aggatcagca gctgctgggc     1680

atctggggct gctctggcaa gctgatctgc tgtaccaatg tgccctggaa ctcctcttgg     1740

tccaacaagt ctcagacaga catctggaat aacatgacct ggatggagtg ggacagggag     1800

atctctaatt acacagatac catctatcgc ctgctggagg acagccagac ccagcaggag     1860

aagaacgaga aggacctgct ggccctggat                                      1890


<210>  8
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Ala Val Gly Asn Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp 
1               5                   10                  15      


Thr Asp Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Thr Lys Ala Tyr 
            20                  25                  30          


Asp Arg Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr 
        35                  40                  45              


Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe 
    50                  55                  60                  


Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile 
65                  70                  75                  80  


Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu 
                85                  90                  95      


Cys Val Thr Leu His Cys Thr Asn Ala Thr Phe Lys Asn Asn Val Thr 
            100                 105                 110         


Asn Asp Met Asn Lys Glu Ile Arg Asn Cys Ser Phe Asn Thr Thr Thr 
        115                 120                 125             


Glu Ile Arg Asp Lys Lys Gln Gln Gly Tyr Ala Leu Phe Tyr Arg Pro 
    130                 135                 140                 


Asp Ile Val Leu Leu Lys Glu Asn Arg Asn Asn Ser Asn Asn Ser Glu 
145                 150                 155                 160 


Tyr Ile Leu Ile Asn Cys Asn Ala Ser Thr Ile Thr Gln Ala Cys Pro 
                165                 170                 175     


Lys Val Asn Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
            180                 185                 190         


Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Ser Gly Lys Gly Pro 
        195                 200                 205             


Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val 
    210                 215                 220                 


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile 
225                 230                 235                 240 


Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile Val 
                245                 250                 255     


His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn 
            260                 265                 270         


Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr 
        275                 280                 285             


Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly 
    290                 295                 300                 


Ser Lys Trp Asn Glu Thr Leu Lys Arg Val Lys Glu Lys Leu Gln Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly Gly 
                325                 330                 335     


Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe 
            340                 345                 350         


Tyr Cys Asn Thr Thr Arg Leu Phe Asn Asn Asn Ala Thr Glu Asp Glu 
        355                 360                 365             


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
    370                 375                 380                 


Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr 
385                 390                 395                 400 


Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Val Arg Asp Gly Gly Glu 
                405                 410                 415     


Asp Asn Lys Thr Glu Glu Ile Phe Arg Pro Gly Gly Gly Asn Met Lys 
            420                 425                 430         


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Ile Glu Leu Lys 
        435                 440                 445             


Pro Leu Gly Ile Ala Pro Thr Gly Cys Lys Arg Arg Val Val Glu Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val 
465                 470                 475                 480 


Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
                485                 490                 495     


Met Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
            500                 505                 510         


Ser Ser Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala 
        515                 520                 525             


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
    530                 535                 540                 


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
545                 550                 555                 560 


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Asn Val Pro 
                565                 570                 575     


Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Thr Asp Ile Trp Asn Asn 
            580                 585                 590         


Met Thr Trp Met Glu Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
        595                 600                 605             


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Thr Gln Gln Glu Lys Asn Glu 
    610                 615                 620                 


Lys Asp Leu Leu Ala Leu Asp 
625                 630     


<210>  9
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
gatatcatca agctgctgaa cgagcaagtg aataaggaga tgcagagctc caacctgtac       60

atgagcatgt ctagctggtg ctatacccac tccctggacg gagcaggact gttcctgttt      120

gatcacgccg ccgaggagta tgagcacgcc aagaagctga tcatctttct gaatgagaac      180

aatgtgcccg tgcagctgac ctccatctct gcccctgagc acaagttcga gggcctgaca      240

cagatctttc agaaggccta cgagcacgag cagcacatca gcgagtccat caacaatatc      300

gtggaccacg ccatcaagtc caaggatcac gccacattca actttctgca gtggtacgtg      360

gccgagcagc acgaggagga ggtgctgttc aaggacatcc tggataagat cgagctgatc      420

ggcaacgaga atcacggcct gtacctggcc gaccagtatg tgaagggcat cgccaagtct      480

cggaagagc                                                              489


<210>  10
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
1               5                   10                  15      


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                  75                  80  


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150                 155                 160 


Arg Lys Ser 
            


<210>  11
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacctggaa gcgga                                                        75


<210>  12
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
ggcagcggcg ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacctggaa gcgga                                                        75


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Gly Ser Gly 
            20                  25  


<210>  14
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Gly Ser Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Ser Gly 
            20                  25              


<210>  15
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
atgcccatgg gcagcctgca gcccctggcc accctgtacc tgctgggcat gctggtggct       60

agcgtgctgg cc                                                           72


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala 
            20                  


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gcggttggta tcggtgcggt tttc                                              24


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
cgcggttggt ctcggtgcgg ttttc                                             25


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
gcggttggtc tcggtgcgat gatc                                              24


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Ala Val Gly Ile Gly Ala Val Phe 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Ala Val Gly Leu Gly Ala Val Phe 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Ala Val Gly Leu Gly Ala Met Ile 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Ala Val Gly Ile Gly Ala Met Ile 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Ala Val Gly Leu Gly Ala Val Leu 
1               5               


<210>  25
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
ggaagcgga                                                                9


<210>  26
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
agcgga                                                                   6


<210>  27
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27
agcgga                                                                   6


<210>  28
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28
ggcagcggc                                                                9


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Gly Ser Gly 
1           


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Gly Ser Gly Gly Ser Gly 
1               5       


<210>  31
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Met Lys Val Met Gly Ile Pro Lys Asn Trp Pro Arg Trp Trp Met Trp 
1               5                   10                  15      


Gly Ile Leu Gly Leu Trp Met Leu Leu Ile Cys Asn Gly Glu Asp Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Pro 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Met Val Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Gly Met Val Glu Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Glu Val Thr Arg Ser Ser Asn Gly Thr Ile Asn Asn Asn Ser 
    130                 135                 140                 


Thr Glu Met Lys Asn Cys Ser Phe Asn Val Thr Thr Asp Leu Arg Asp 
145                 150                 155                 160 


Lys Lys Lys Lys Glu His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro 
                165                 170                 175     


Leu Asp Glu Thr Asn Gly Thr Ser Ser Glu Tyr Arg Leu Ile Asn Cys 
            180                 185                 190         


Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Ile Ala Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn 
            260                 265                 270         


Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Val Thr Val 
        275                 280                 285             


Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg 
    290                 295                 300                 


Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Ile Ser Arg Glu Lys Trp Asn Arg Thr 
                325                 330                 335     


Leu Gln Lys Val Glu Lys Lys Leu Glu Glu Leu Phe Pro Asn Lys Thr 
            340                 345                 350         


Ile His Phe Thr Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Met Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ala Leu 
    370                 375                 380                 


Phe Asn Asn Asn Asn Asp Ser Thr Asn Ser Asn Ile Thr Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Arg Gln Phe Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Gln Gly Val Ile Thr Cys Lys Ser Asn Val Thr 
            420                 425                 430         


Gly Leu Leu Leu Thr Arg Asp Gly Gly Ile Ile Asn Asp Thr Glu Ile 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr 
465                 470                 475                 480 


Thr Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile 
                485                 490                 495     


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
            500                 505                 510         


Ala Ala Ser Ile Thr Leu Thr Ala Gln Ala Arg Gln Leu Leu Ser Gly 
        515                 520                 525             


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
    530                 535                 540                 


His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg 
545                 550                 555                 560 


Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
                565                 570                 575     


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn 
            580                 585                 590         


Gly Ser Trp Ser Asn Lys Ser Gln Asp Glu Ile Trp His Asn Met Thr 
        595                 600                 605             


Trp Met Gln Trp Asp Lys Glu Ile Asn Asn Tyr Thr Asn Ile Ile Tyr 
    610                 615                 620                 


Gly Leu Leu Glu Val Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
625                 630                 635                 640 


Leu Leu Ala Leu Asp Lys Trp Gln Asn Leu Trp Ser Trp Phe Asn Ile 
                645                 650                 655     


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
            660                 665                 670         


Leu Ile Gly Leu Arg Ile Ile Phe Thr Val Leu Ser Ile Val Asn Arg 
        675                 680                 685             


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn 
    690                 695                 700                 


Pro Arg Gly Pro Asp Arg Pro Arg Gly Ile Glu Glu Glu Gly Gly Glu 
705                 710                 715                 720 


Gln Asp Arg Ser Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu 
                725                 730                 735     


Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu 
            740                 745                 750         


Arg Asp Leu Ile Leu Ile Ala Ala Arg Val Val Glu Leu Leu Gly Gln 
        755                 760                 765             


Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp 
    770                 775                 780                 


Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Phe Asp Thr Ile Ala 
785                 790                 795                 800 


Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Leu Gln Gly 
                805                 810                 815     


Ile Gly Arg Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe 
            820                 825                 830         


Glu Ala Ala Leu Gln 
        835         


<210>  32
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Gly Glu Asp Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Pro Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Gly Met Val Glu 
                85                  90                  95      


Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Glu Val 
        115                 120                 125             


Thr Arg Ser Ser Asn Gly Thr Ile Asn Asn Asn Ser Thr Glu Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Val Thr Thr Asp Leu Arg Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Glu Thr 
                165                 170                 175     


Asn Gly Thr Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
            180                 185                 190         


Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Lys Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Ile Ala Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn 
            260                 265                 270         


Ala Lys Ile Ile Ile Val Gln Leu Asn Val Thr Val Glu Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Ile Ser Arg Glu Lys Trp Asn Arg Thr Leu Gln Lys Val 
                325                 330                 335     


Glu Lys Lys Leu Glu Glu Leu Phe Pro Asn Lys Thr Ile His Phe Thr 
            340                 345                 350         


Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Met Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ala Leu Phe Asn Asn Asn 
    370                 375                 380                 


Asn Asp Ser Thr Asn Ser Asn Ile Thr Leu Pro Cys Arg Ile Arg Gln 
385                 390                 395                 400 


Phe Ile Asn Met Trp Gln Glu Val Gly Arg Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Thr Cys Lys Ser Asn Val Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Ile Ile Asn Asp Thr Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Thr Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Ala Val Pro Trp Asn Gly Ser Trp Ser Asn Lys Ser Gln Asp 
        595                 600                 605             


Glu Ile Trp His Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn 
    610                 615                 620                 


Asn Tyr Thr Asn Ile Ile Tyr Gly Leu Leu Glu Val Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650         


<210>  33
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Gly Glu Asp Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Pro Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Gly Met Val Glu 
                85                  90                  95      


Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Glu Val 
        115                 120                 125             


Thr Arg Ser Ser Asn Gly Thr Ile Asn Asn Asn Ser Thr Glu Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Val Thr Thr Asp Leu Arg Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Glu Thr 
                165                 170                 175     


Asn Gly Thr Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
            180                 185                 190         


Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Lys Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Ile Ala Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn 
            260                 265                 270         


Ala Lys Ile Ile Ile Val Gln Leu Asn Val Thr Val Glu Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Ile Ser Arg Glu Lys Trp Asn Arg Thr Leu Gln Lys Val 
                325                 330                 335     


Glu Lys Lys Leu Glu Glu Leu Phe Pro Asn Lys Thr Ile His Phe Thr 
            340                 345                 350         


Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Met Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ala Leu Phe Asn Asn Asn 
    370                 375                 380                 


Asn Asp Ser Thr Asn Ser Asn Ile Thr Leu Pro Cys Arg Ile Arg Gln 
385                 390                 395                 400 


Phe Ile Asn Met Trp Gln Glu Val Gly Arg Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Thr Cys Lys Ser Asn Val Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Ile Ile Asn Asp Thr Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Thr Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Ala Val Pro Trp Asn Gly Ser Trp Ser Asn Lys Ser Gln Asp 
        595                 600                 605             


Glu Ile Trp His Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn 
    610                 615                 620                 


Asn Tyr Thr Asn Ile Ile Tyr Gly Leu Leu Glu Val Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Gln Asn 
                645                 650                 655     


Leu Trp Ser Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Thr 
        675                 680                 685             


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Asp Arg Pro Arg Gly 
705                 710                 715                 720 


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Ser Arg Ser Ile Arg Leu 
                725                 730                 735     


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Ile Leu Ile Ala Ala Arg 
        755                 760                 765             


Val Val Glu Leu Leu Gly Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu 
    770                 775                 780                 


Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile 
785                 790                 795                 800 


Ser Leu Phe Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
                805                 810                 815     


Ile Ile Glu Val Leu Gln Gly Ile Gly Arg Ala Ile Cys Asn Ile Pro 
            820                 825                 830         


Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
        835                 840                 


<210>  34
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Gly Glu Asp Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Pro Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Gly Met Val Glu 
                85                  90                  95      


Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Glu Val 
        115                 120                 125             


Thr Arg Ser Ser Asn Gly Thr Ile Asn Asn Asn Ser Thr Glu Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Val Thr Thr Asp Leu Arg Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Glu Thr 
                165                 170                 175     


Asn Gly Thr Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
            180                 185                 190         


Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Lys Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Ile Ala Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn 
            260                 265                 270         


Ala Lys Ile Ile Ile Val Gln Leu Asn Val Thr Val Glu Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Ile Ser Arg Glu Lys Trp Asn Arg Thr Leu Gln Lys Val 
                325                 330                 335     


Glu Lys Lys Leu Glu Glu Leu Phe Pro Asn Lys Thr Ile His Phe Thr 
            340                 345                 350         


Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Met Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ala Leu Phe Asn Asn Asn 
    370                 375                 380                 


Asn Asp Ser Thr Asn Ser Asn Ile Thr Leu Pro Cys Arg Ile Arg Gln 
385                 390                 395                 400 


Phe Ile Asn Met Trp Gln Glu Val Gly Arg Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Thr Cys Lys Ser Asn Val Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Ile Ile Asn Asp Thr Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Thr Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Ala Val Pro Trp Asn Gly Ser Trp Ser Asn Lys Ser Gln Asp 
        595                 600                 605             


Glu Ile Trp His Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn 
    610                 615                 620                 


Asn Tyr Thr Asn Ile Ile Tyr Gly Leu Leu Glu Val Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Gly Ser Gly 
                645                 650                 655     


Gly Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val 
            660                 665                 670         


Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp 
        675                 680                 685             


Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser 
    690                 695                 700                 


Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg 
705                 710                 715                 720 


Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro 
                725                 730                 735     


Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu 
            740                 745                 750         


Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala 
        755                 760                 765             


Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu 
    770                 775                 780                 


Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala 
785                 790                 795                 800 


Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu 
                805                 810                 815     


Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
            820                 825                 830 


<210>  35
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Met Arg Val Lys Gly Ile Lys Lys Asn Tyr Gln His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Met Met Ile Phe Gly Leu Leu Met Ile Cys Ser Ala Ala Asp Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Thr Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Arg Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Arg Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ile Asp Tyr Tyr Gly Asn Thr Thr Asn Ser Asn Asn Ser Ser 
    130                 135                 140                 


Glu Thr Met Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
145                 150                 155                 160 


Thr Thr Arg Leu Lys Asp Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr 
                165                 170                 175     


Lys Tyr Asp Ile Val Pro Ile Asp Asn Arg Val Gly Asn Asp Thr Ser 
            180                 185                 190         


Asn Ala Thr Ser Tyr Arg Leu Thr Ser Cys Asn Thr Ser Val Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Val Met Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Ile His Met Gly Pro Gly Lys Val 
305                 310                 315                 320 


Phe Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
                325                 330                 335     


Asn Ile Asn Arg Ala Lys Trp Asn Asn Thr Leu Ile Lys Ile Val Glu 
            340                 345                 350         


Lys Leu Arg Val Lys Phe Asn Lys Thr Ile Ser Phe Lys Gln Ser Ser 
        355                 360                 365             


Gly Gly Asp Pro Glu Ile Glu Met His Ser Phe Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn 
385                 390                 395                 400 


Asn Ala Thr Leu Asn Val Asn Ser Asn Val Thr Glu Gly Ser Glu Asn 
                405                 410                 415     


Ile Thr Leu Pro Cys Arg Ile Arg Gln Ile Val Asn Met Trp Gln Glu 
            420                 425                 430         


Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Gln Gly Gln Ile Arg Cys 
        435                 440                 445             


Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Gly Ser 
    450                 455                 460                 


Asn Ser Ser Asn Thr Ser Glu Glu Val Phe Arg Pro Gly Gly Gly Asn 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys 
                485                 490                 495     


Ile Glu Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val 
            500                 505                 510         


Gln Arg Glu Lys Arg Thr Val Gly Ile Gly Ala Leu Phe Leu Gly Phe 
        515                 520                 525             


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr 
    530                 535                 540                 


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn 
545                 550                 555                 560 


Leu Leu Arg Ala Ile Gln Ala Gln Gln His Leu Leu Gln Leu Thr Val 
                565                 570                 575     


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
            580                 585                 590         


Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
        595                 600                 605             


Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser 
    610                 615                 620                 


Leu Asn Glu Ile Trp Asp Asn Met Thr Trp Met Glu Trp Glu Lys Glu 
625                 630                 635                 640 


Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln 
                645                 650                 655     


Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 
            660                 665                 670         


Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Asn Trp Leu Trp Tyr Ile 
        675                 680                 685             


Lys Ile Phe Ile Met Ile Val Gly Gly Ser Ile Gly Leu Arg Ile Val 
    690                 695                 700                 


Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
705                 710                 715                 720 


Leu Ser Phe Gln Thr Arg Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro 
                725                 730                 735     


Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Gly 
            740                 745                 750         


Gln Leu Val Asn Gly Phe Leu Ala Ile Ile Trp Val Asp Leu Arg Ser 
        755                 760                 765             


Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val 
    770                 775                 780                 


Ala Arg Val Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Asn 
785                 790                 795                 800 


Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Lys Ser 
                805                 810                 815     


Ala Ile Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr 
            820                 825                 830         


Asp Arg Val Ile Glu Val Val Gln Arg Thr Cys Arg Ala Ile Ile His 
        835                 840                 845             


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu Leu 
    850                 855                 860         


<210>  36
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Asp Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Thr Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Arg Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Arg Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ile Asp Tyr 
        115                 120                 125             


Tyr Gly Asn Thr Thr Asn Ser Asn Asn Ser Ser Glu Thr Met Met Glu 
    130                 135                 140                 


Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Arg Leu Lys 
145                 150                 155                 160 


Asp Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Tyr Asp Ile Val 
                165                 170                 175     


Pro Ile Asp Asn Arg Val Gly Asn Asp Thr Ser Asn Ala Thr Ser Tyr 
            180                 185                 190         


Arg Leu Thr Ser Cys Asn Thr Ser Val Cys Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
        275                 280                 285             


Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile His Met Gly Pro Gly Lys Val Phe Tyr Thr Thr Gly 
305                 310                 315                 320 


Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Asn Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Ile Lys Ile Val Glu Lys Leu Arg Val Lys 
            340                 345                 350         


Phe Asn Lys Thr Ile Ser Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Glu Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Asn Ala Thr Leu Asn 
385                 390                 395                 400 


Val Asn Ser Asn Val Thr Glu Gly Ser Glu Asn Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Arg Gln Ile Val Asn Met Trp Gln Glu Val Gly Lys Cys Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Gln Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Gly Ser Asn Ser Ser Asn Thr 
    450                 455                 460                 


Ser Glu Glu Val Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
                485                 490                 495     


Ile Ala Pro Thr Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Thr Val Gly Ile Gly 
        515                 520                 525             


Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
    530                 535                 540                 


Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
545                 550                 555                 560 


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Pro Gln Ala Gln Gln His 
                565                 570                 575     


Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
            580                 585                 590         


Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
        595                 600                 605             


Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp Asn Ala 
    610                 615                 620                 


Ser Trp Ser Asn Lys Ser Leu Asn Glu Ile Trp Asp Asn Met Thr Trp 
625                 630                 635                 640 


Met Glu Trp Glu Lys Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr 
                645                 650                 655     


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
            660                 665                 670         


Leu Glu Leu Asp 
        675     


<210>  37
<211>  868
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Asp Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Thr Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Arg Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Arg Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ile Asp Tyr 
        115                 120                 125             


Tyr Gly Asn Thr Thr Asn Ser Asn Asn Ser Ser Glu Thr Met Met Glu 
    130                 135                 140                 


Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Arg Leu Lys 
145                 150                 155                 160 


Asp Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Tyr Asp Ile Val 
                165                 170                 175     


Pro Ile Asp Asn Arg Val Gly Asn Asp Thr Ser Asn Ala Thr Ser Tyr 
            180                 185                 190         


Arg Leu Thr Ser Cys Asn Thr Ser Val Cys Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
        275                 280                 285             


Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile His Met Gly Pro Gly Lys Val Phe Tyr Thr Thr Gly 
305                 310                 315                 320 


Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Asn Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Ile Lys Ile Val Glu Lys Leu Arg Val Lys 
            340                 345                 350         


Phe Asn Lys Thr Ile Ser Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Glu Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Asn Ala Thr Leu Asn 
385                 390                 395                 400 


Val Asn Ser Asn Val Thr Glu Gly Ser Glu Asn Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Arg Gln Ile Val Asn Met Trp Gln Glu Val Gly Lys Cys Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Gln Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Gly Ser Asn Ser Ser Asn Thr 
    450                 455                 460                 


Ser Glu Glu Val Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
                485                 490                 495     


Ile Ala Pro Thr Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Thr Val Gly Ile Gly 
        515                 520                 525             


Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
    530                 535                 540                 


Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
545                 550                 555                 560 


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Pro Gln Ala Gln Gln His 
                565                 570                 575     


Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
            580                 585                 590         


Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
        595                 600                 605             


Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp Asn Ala 
    610                 615                 620                 


Ser Trp Ser Asn Lys Ser Leu Asn Glu Ile Trp Asp Asn Met Thr Trp 
625                 630                 635                 640 


Met Glu Trp Glu Lys Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr 
                645                 650                 655     


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
            660                 665                 670         


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr 
        675                 680                 685             


Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Ser 
    690                 695                 700                 


Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val 
705                 710                 715                 720 


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Arg Leu Pro Thr Pro 
                725                 730                 735     


Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg 
            740                 745                 750         


Asp Arg Asp Arg Ser Gly Gln Leu Val Asn Gly Phe Leu Ala Ile Ile 
        755                 760                 765             


Trp Val Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
    770                 775                 780                 


Asp Leu Leu Leu Ile Val Ala Arg Val Val Glu Leu Leu Gly Arg Arg 
785                 790                 795                 800 


Gly Trp Glu Ala Leu Asn Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser 
                805                 810                 815     


Gln Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asn Ala Thr Ala Ile 
            820                 825                 830         


Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Val Gln Arg Thr 
        835                 840                 845             


Cys Arg Ala Ile Ile His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu 
    850                 855                 860                 


Arg Leu Leu Leu 
865             


<210>  38
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Asp Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Thr Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Arg Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Arg Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ile Asp Tyr 
        115                 120                 125             


Tyr Gly Asn Thr Thr Asn Ser Asn Asn Ser Ser Glu Thr Met Met Glu 
    130                 135                 140                 


Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Arg Leu Lys 
145                 150                 155                 160 


Asp Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Tyr Asp Ile Val 
                165                 170                 175     


Pro Ile Asp Asn Arg Val Gly Asn Asp Thr Ser Asn Ala Thr Ser Tyr 
            180                 185                 190         


Arg Leu Thr Ser Cys Asn Thr Ser Val Cys Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
        275                 280                 285             


Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile His Met Gly Pro Gly Lys Val Phe Tyr Thr Thr Gly 
305                 310                 315                 320 


Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Asn Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Ile Lys Ile Val Glu Lys Leu Arg Val Lys 
            340                 345                 350         


Phe Asn Lys Thr Ile Ser Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Glu Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Asn Ala Thr Leu Asn 
385                 390                 395                 400 


Val Asn Ser Asn Val Thr Glu Gly Ser Glu Asn Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Arg Gln Ile Val Asn Met Trp Gln Glu Val Gly Lys Cys Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Gln Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Gly Ser Asn Ser Ser Asn Thr 
    450                 455                 460                 


Ser Glu Glu Val Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
                485                 490                 495     


Ile Ala Pro Thr Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Thr Val Gly Ile Gly 
        515                 520                 525             


Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
    530                 535                 540                 


Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
545                 550                 555                 560 


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Pro Gln Ala Gln Gln His 
                565                 570                 575     


Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
            580                 585                 590         


Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
        595                 600                 605             


Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp Asn Ala 
    610                 615                 620                 


Ser Trp Ser Asn Lys Ser Leu Asn Glu Ile Trp Asp Asn Met Thr Trp 
625                 630                 635                 640 


Met Glu Trp Glu Lys Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr 
                645                 650                 655     


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
            660                 665                 670         


Leu Glu Leu Asp Gly Gly Ser Gly Gly Arg Ser Cys Arg Asn Ser Met 
        675                 680                 685             


Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala 
    690                 695                 700                 


Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala 
705                 710                 715                 720 


Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys 
                725                 730                 735     


Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser 
            740                 745                 750         


Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly 
        755                 760                 765             


Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys 
    770                 775                 780                 


Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn 
785                 790                 795                 800 


Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln 
                805                 810                 815     


Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys 
            820                 825                 830         


Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys 
        835                 840                 845             


Leu Leu Gly Ile Asp Val 
    850                 


<210>  39
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Met Arg Val Met Gly Ile Leu Arg Ser Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Trp Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Lys Glu Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asp Val Lys Ile Lys Gly Thr Asn Ala Thr Tyr Asn Asn 
    130                 135                 140                 


Ala Thr Tyr Asn Asn Asn Asn Thr Ile Ser Asp Met Lys Asn Cys Ser 
145                 150                 155                 160 


Phe Asn Thr Thr Thr Glu Ile Thr Asp Lys Lys Lys Lys Glu Tyr Ala 
                165                 170                 175     


Leu Phe Tyr Lys Leu Asp Val Val Ala Leu Asp Gly Lys Glu Thr Asn 
            180                 185                 190         


Ser Thr Asn Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala 
        195                 200                 205             


Val Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
    210                 215                 220                 


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr 
225                 230                 235                 240 


Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr 
                245                 250                 255     


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
            260                 265                 270         


Leu Ala Glu Glu Glu Val Val Ile Arg Phe Glu Asn Leu Thr Asn Asn 
        275                 280                 285             


Ala Lys Ile Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Asn Cys 
    290                 295                 300                 


Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly 
305                 310                 315                 320 


Gln Thr Phe Phe Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
                325                 330                 335     


His Cys Asn Ile Ser Arg Lys Lys Trp Asn Thr Thr Leu Gln Arg Val 
            340                 345                 350         


Lys Glu Lys Leu Lys Glu Lys Phe Pro Asn Lys Thr Ile Gln Phe Ala 
        355                 360                 365             


Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
    370                 375                 380                 


Arg Gly Glu Phe Phe Tyr Cys Tyr Thr Ser Asp Leu Phe Asn Ser Thr 
385                 390                 395                 400 


Tyr Met Ser Asn Asn Thr Gly Gly Ala Asn Ile Thr Leu Gln Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Arg Met Trp Gln Gly Val Gly Gln Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Leu Leu Thr Arg Asp Gly Gly Lys Glu Lys Asn Asp Thr Glu Thr 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Asp 
                485                 490                 495     


Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile 
            500                 505                 510         


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg 
                565                 570                 575     


Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn 
        595                 600                 605             


Ala Ser Trp Ser Asn Lys Ser Tyr Glu Glu Ile Trp Gly Asn Met Thr 
    610                 615                 620                 


Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr 
625                 630                 635                 640 


Ser Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Ser Trp Glu Ser Leu Trp Ser Trp Phe Asn Ile 
            660                 665                 670         


Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Ile Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser 
705                 710                 715                 720 


Pro Arg Glu Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu 
                725                 730                 735     


Gln Asp Arg Ala Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala Leu 
            740                 745                 750         


Ala Trp Glu Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu 
        755                 760                 765             


Arg Asp Leu Ile Leu Ile Ala Ala Arg Ala Ala Ala Leu Leu Gly Arg 
    770                 775                 780                 


Ser Ser Leu Trp Gly Leu Gln Lys Gly Trp Glu Ala Leu Lys Tyr Leu 
785                 790                 795                 800 


Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile 
                805                 810                 815     


Ser Leu Phe Asp Ala Ile Ala Ile Thr Val Ala Glu Gly Thr Asp Arg 
            820                 825                 830         


Ile Ile Asn Ile Val Gln Arg Ile Ser Arg Ala Phe Tyr Asn Ile Pro 
        835                 840                 845             


Arg Arg Ile Arg Gln Gly Phe Glu Ala Thr Leu Gln 
    850                 855                 860 


<210>  40
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys 
            20                  25                  30          


Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Lys 
        35                  40                  45              


Glu Glu Val His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp 
    50                  55                  60                  


Pro Asn Pro Gln Glu Ile Val Leu Lys Asn Val Thr Glu Asn Phe Asn 
65                  70                  75                  80  


Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser 
                85                  90                  95      


Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys 
            100                 105                 110         


Val Thr Leu Asn Cys Ser Asp Val Lys Ile Lys Gly Thr Asn Ala Thr 
        115                 120                 125             


Tyr Asn Asn Ala Thr Tyr Asn Asn Asn Asn Thr Ile Ser Asp Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Thr Thr Thr Glu Ile Thr Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Ala Leu Asp Gly Lys 
                165                 170                 175     


Glu Thr Asn Ser Thr Asn Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Phe Glu Asn Leu 
            260                 265                 270         


Thr Asn Asn Ala Lys Ile Ile Ile Val His Leu Asn Glu Ser Val Glu 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser Val Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Thr Phe Phe Ala Thr Gly Asp Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Ser Arg Lys Lys Trp Asn Thr Thr Leu 
                325                 330                 335     


Gln Arg Val Lys Glu Lys Leu Lys Glu Lys Phe Pro Asn Lys Thr Ile 
            340                 345                 350         


Gln Phe Ala Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Tyr Thr Ser Asp Leu Phe 
    370                 375                 380                 


Asn Ser Thr Tyr Met Ser Asn Asn Thr Gly Gly Ala Asn Ile Thr Leu 
385                 390                 395                 400 


Gln Cys Arg Ile Lys Gln Ile Ile Arg Met Trp Gln Gly Val Gly Gln 
                405                 410                 415     


Cys Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Glu Lys Asn Asp 
        435                 440                 445             


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile 
465                 470                 475                 480 


Ala Pro Asp Lys Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala 
            500                 505                 510         


Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
                565                 570                 575     


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp Asn Ala Ser 
        595                 600                 605             


Trp Ser Asn Lys Ser Tyr Glu Glu Ile Trp Gly Asn Met Thr Trp Met 
    610                 615                 620                 


Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Ser Leu 
625                 630                 635                 640 


Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
                645                 650                 655     


Ala Leu Asp 
            


<210>  41
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys 
            20                  25                  30          


Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Lys 
        35                  40                  45              


Glu Glu Val His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp 
    50                  55                  60                  


Pro Asn Pro Gln Glu Ile Val Leu Lys Asn Val Thr Glu Asn Phe Asn 
65                  70                  75                  80  


Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser 
                85                  90                  95      


Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys 
            100                 105                 110         


Val Thr Leu Asn Cys Ser Asp Val Lys Ile Lys Gly Thr Asn Ala Thr 
        115                 120                 125             


Tyr Asn Asn Ala Thr Tyr Asn Asn Asn Asn Thr Ile Ser Asp Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Thr Thr Thr Glu Ile Thr Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Ala Leu Asp Gly Lys 
                165                 170                 175     


Glu Thr Asn Ser Thr Asn Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Phe Glu Asn Leu 
            260                 265                 270         


Thr Asn Asn Ala Lys Ile Ile Ile Val His Leu Asn Glu Ser Val Glu 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser Val Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Thr Phe Phe Ala Thr Gly Asp Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Ser Arg Lys Lys Trp Asn Thr Thr Leu 
                325                 330                 335     


Gln Arg Val Lys Glu Lys Leu Lys Glu Lys Phe Pro Asn Lys Thr Ile 
            340                 345                 350         


Gln Phe Ala Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Tyr Thr Ser Asp Leu Phe 
    370                 375                 380                 


Asn Ser Thr Tyr Met Ser Asn Asn Thr Gly Gly Ala Asn Ile Thr Leu 
385                 390                 395                 400 


Gln Cys Arg Ile Lys Gln Ile Ile Arg Met Trp Gln Gly Val Gly Gln 
                405                 410                 415     


Cys Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Glu Lys Asn Asp 
        435                 440                 445             


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile 
465                 470                 475                 480 


Ala Pro Asp Lys Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala 
            500                 505                 510         


Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
                565                 570                 575     


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp Asn Ala Ser 
        595                 600                 605             


Trp Ser Asn Lys Ser Tyr Glu Glu Ile Trp Gly Asn Met Thr Trp Met 
    610                 615                 620                 


Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Ser Leu 
625                 630                 635                 640 


Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
                645                 650                 655     


Ala Leu Asp Ser Trp Glu Ser Leu Trp Ser Trp Phe Asn Ile Thr Asn 
            660                 665                 670         


Trp Leu Trp Tyr Ile Arg Ile Phe Ile Ile Ile Val Gly Gly Leu Ile 
        675                 680                 685             


Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg 
    690                 695                 700                 


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser Pro Arg 
705                 710                 715                 720 


Glu Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp 
                725                 730                 735     


Arg Ala Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp 
            740                 745                 750         


Glu Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp 
        755                 760                 765             


Leu Ile Leu Ile Ala Ala Arg Ala Ala Ala Leu Leu Gly Arg Ser Ser 
    770                 775                 780                 


Leu Trp Gly Leu Gln Lys Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser 
785                 790                 795                 800 


Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu 
                805                 810                 815     


Phe Asp Ala Ile Ala Ile Thr Val Ala Glu Gly Thr Asp Arg Ile Ile 
            820                 825                 830         


Asn Ile Val Gln Arg Ile Ser Arg Ala Phe Tyr Asn Ile Pro Arg Arg 
        835                 840                 845             


Ile Arg Gln Gly Phe Glu Ala Thr Leu Gln 
    850                 855             


<210>  42
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys 
            20                  25                  30          


Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Lys 
        35                  40                  45              


Glu Glu Val His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp 
    50                  55                  60                  


Pro Asn Pro Gln Glu Ile Val Leu Lys Asn Val Thr Glu Asn Phe Asn 
65                  70                  75                  80  


Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser 
                85                  90                  95      


Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys 
            100                 105                 110         


Val Thr Leu Asn Cys Ser Asp Val Lys Ile Lys Gly Thr Asn Ala Thr 
        115                 120                 125             


Tyr Asn Asn Ala Thr Tyr Asn Asn Asn Asn Thr Ile Ser Asp Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Thr Thr Thr Glu Ile Thr Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Ala Leu Asp Gly Lys 
                165                 170                 175     


Glu Thr Asn Ser Thr Asn Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Phe Glu Asn Leu 
            260                 265                 270         


Thr Asn Asn Ala Lys Ile Ile Ile Val His Leu Asn Glu Ser Val Glu 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser Val Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Thr Phe Phe Ala Thr Gly Asp Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Ser Arg Lys Lys Trp Asn Thr Thr Leu 
                325                 330                 335     


Gln Arg Val Lys Glu Lys Leu Lys Glu Lys Phe Pro Asn Lys Thr Ile 
            340                 345                 350         


Gln Phe Ala Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Tyr Thr Ser Asp Leu Phe 
    370                 375                 380                 


Asn Ser Thr Tyr Met Ser Asn Asn Thr Gly Gly Ala Asn Ile Thr Leu 
385                 390                 395                 400 


Gln Cys Arg Ile Lys Gln Ile Ile Arg Met Trp Gln Gly Val Gly Gln 
                405                 410                 415     


Cys Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Glu Lys Asn Asp 
        435                 440                 445             


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile 
465                 470                 475                 480 


Ala Pro Asp Lys Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala 
            500                 505                 510         


Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
                565                 570                 575     


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp Asn Ala Ser 
        595                 600                 605             


Trp Ser Asn Lys Ser Tyr Glu Glu Ile Trp Gly Asn Met Thr Trp Met 
    610                 615                 620                 


Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Ser Leu 
625                 630                 635                 640 


Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
                645                 650                 655     


Ala Leu Asp Gly Gly Ser Gly Gly Glu Tyr Gly Ser His Gly Asn Val 
            660                 665                 670         


Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr 
        675                 680                 685             


Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg 
    690                 695                 700                 


Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser 
705                 710                 715                 720 


Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met 
                725                 730                 735     


Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr 
            740                 745                 750         


Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln 
        755                 760                 765             


Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg 
    770                 775                 780                 


Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu 
785                 790                 795                 800 


Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His 
                805                 810                 815     


Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu 
            820                 825                 830         


Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
        835                 840                 845         


<210>  43
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Leu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asn Met Val Glu Gln Met Gln Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
        115                 120                 125             


Leu Glu Cys His Asp Val Asn Val Asn Gly Thr Ala Asn Asn Gly Thr 
    130                 135                 140                 


Thr Asn Val Thr Glu Ser Gly Val Asn Ser Ser Asp Val Thr Ser Asn 
145                 150                 155                 160 


Asn Val Thr Asn Ser Asn Trp Gly Thr Met Glu Lys Gly Glu Ile Lys 
                165                 170                 175     


Asn Cys Ser Phe Asn Ile Thr Thr Asn Ile Arg Asp Lys Met Gln Lys 
            180                 185                 190         


Glu Thr Ala Gln Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Gln 
        195                 200                 205             


Asn Lys Thr Asn Asn Thr Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
    210                 215                 220                 


Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile 
225                 230                 235                 240 


His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Arg 
                245                 250                 255     


Asn Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys 
            260                 265                 270         


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
        275                 280                 285             


Ser Leu Ala Glu Ala Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn 
    290                 295                 300                 


Asn Ala Lys Thr Ile Ile Ile Gln Leu Asn Glu Thr Val Glu Ile Asn 
305                 310                 315                 320 


Cys Thr Arg Pro Asn Asn Asn Thr Ser Lys Arg Ile Ser Ile Gly Pro 
                325                 330                 335     


Gly Arg Ala Phe Arg Ala Thr Lys Ile Ile Gly Asn Ile Arg Gln Ala 
            340                 345                 350         


His Cys Asn Ile Ser Arg Ala Thr Trp Asn Ser Thr Leu Lys Lys Ile 
        355                 360                 365             


Val Ala Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Gln 
    370                 375                 380                 


Pro Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys 
385                 390                 395                 400 


Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr 
                405                 410                 415     


Trp Asn Ser Thr Glu Glu Ser Asn Ser Thr Glu Glu Gly Thr Ile Thr 
            420                 425                 430         


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
        435                 440                 445             


Lys Ala Met Tyr Ala Pro Pro Ile Glu Gly Gln Ile Arg Cys Ser Ser 
    450                 455                 460                 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Lys 
465                 470                 475                 480 


Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
                485                 490                 495     


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
            500                 505                 510         


Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu 
        515                 520                 525             


Lys Arg Ala Val Gly Ile Val Gly Ala Met Phe Leu Gly Phe Leu Gly 
    530                 535                 540                 


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln 
545                 550                 555                 560 


Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
                565                 570                 575     


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
            580                 585                 590         


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
        595                 600                 605             


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
    610                 615                 620                 


Thr Thr Thr Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Leu Ser 
625                 630                 635                 640 


Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp 
                645                 650                 655     


Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln 
            660                 665                 670         


Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Gly 
        675                 680                 685             


Leu Trp Asn Trp Phe Glu Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
    690                 695                 700                 


Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala 
705                 710                 715                 720 


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Val Ser 
                725                 730                 735     


Phe Gln Thr His Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly 
            740                 745                 750         


Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Gly Arg Ser Val Arg Leu 
        755                 760                 765             


Val Asn Gly Phe Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys 
    770                 775                 780                 


Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Ile Ala Arg 
785                 790                 795                 800 


Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp 
                805                 810                 815     


Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val 
            820                 825                 830         


Asn Leu Leu Asp Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
        835                 840                 845             


Ile Ile Glu Val Val Arg Arg Ala Phe Arg Ala Ile Leu His Ile Pro 
    850                 855                 860                 


Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
865                 870                 875     


<210>  44
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Glu Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Glu Cys His Asp Val 
        115                 120                 125             


Asn Val Asn Gly Thr Ala Asn Asn Gly Thr Thr Asn Val Thr Glu Ser 
    130                 135                 140                 


Gly Val Asn Ser Ser Asp Val Thr Ser Asn Asn Val Thr Asn Ser Asn 
145                 150                 155                 160 


Trp Gly Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
                165                 170                 175     


Thr Thr Asn Ile Arg Asp Lys Met Gln Lys Glu Thr Ala Gln Phe Tyr 
            180                 185                 190         


Lys Leu Asp Ile Val Pro Ile Glu Asp Gln Asn Lys Thr Asn Asn Thr 
        195                 200                 205             


Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Cys Thr Gln Ala Cys 
    210                 215                 220                 


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
225                 230                 235                 240 


Gly Phe Ala Ile Leu Lys Cys Asn Asp Arg Asn Phe Asn Gly Thr Gly 
                245                 250                 255     


Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
            260                 265                 270         


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Ala Glu 
        275                 280                 285             


Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile 
    290                 295                 300                 


Ile Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
305                 310                 315                 320 


Asn Thr Ser Lys Arg Ile Ser Ile Gly Pro Gly Arg Ala Phe Arg Ala 
                325                 330                 335     


Thr Lys Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile Ser Arg 
            340                 345                 350         


Ala Thr Trp Asn Ser Thr Leu Lys Lys Ile Val Ala Lys Leu Arg Glu 
        355                 360                 365             


Gln Phe Gly Asn Lys Thr Ile Val Phe Gln Pro Ser Ser Gly Gly Asp 
    370                 375                 380                 


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
385                 390                 395                 400 


Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Ser Thr Glu Glu 
                405                 410                 415     


Ser Asn Ser Thr Glu Glu Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
            420                 425                 430         


Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro 
        435                 440                 445             


Pro Ile Glu Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
    450                 455                 460                 


Leu Thr Arg Asp Gly Gly Asn Asn Asn Lys Thr Asn Gly Thr Glu Ile 
465                 470                 475                 480 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                485                 490                 495     


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr 
            500                 505                 510         


Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Val Gly Ala Met Phe 
    530                 535                 540                 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
545                 550                 555                 560 


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
                565                 570                 575     


Gln Asn Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln 
            580                 585                 590         


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
        595                 600                 605             


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
    610                 615                 620                 


Gly Lys Leu Ile Cys Cys Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
625                 630                 635                 640 


Asn Lys Ser Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp 
                645                 650                 655     


Glu Arg Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu 
            660                 665                 670         


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
        675                 680                 685             


Asp 
    


<210>  45
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Glu Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Glu Cys His Asp Val 
        115                 120                 125             


Asn Val Asn Gly Thr Ala Asn Asn Gly Thr Thr Asn Val Thr Glu Ser 
    130                 135                 140                 


Gly Val Asn Ser Ser Asp Val Thr Ser Asn Asn Val Thr Asn Ser Asn 
145                 150                 155                 160 


Trp Gly Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
                165                 170                 175     


Thr Thr Asn Ile Arg Asp Lys Met Gln Lys Glu Thr Ala Gln Phe Tyr 
            180                 185                 190         


Lys Leu Asp Ile Val Pro Ile Glu Asp Gln Asn Lys Thr Asn Asn Thr 
        195                 200                 205             


Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Cys Thr Gln Ala Cys 
    210                 215                 220                 


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
225                 230                 235                 240 


Gly Phe Ala Ile Leu Lys Cys Asn Asp Arg Asn Phe Asn Gly Thr Gly 
                245                 250                 255     


Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
            260                 265                 270         


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Ala Glu 
        275                 280                 285             


Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile 
    290                 295                 300                 


Ile Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
305                 310                 315                 320 


Asn Thr Ser Lys Arg Ile Ser Ile Gly Pro Gly Arg Ala Phe Arg Ala 
                325                 330                 335     


Thr Lys Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile Ser Arg 
            340                 345                 350         


Ala Thr Trp Asn Ser Thr Leu Lys Lys Ile Val Ala Lys Leu Arg Glu 
        355                 360                 365             


Gln Phe Gly Asn Lys Thr Ile Val Phe Gln Pro Ser Ser Gly Gly Asp 
    370                 375                 380                 


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
385                 390                 395                 400 


Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Ser Thr Glu Glu 
                405                 410                 415     


Ser Asn Ser Thr Glu Glu Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
            420                 425                 430         


Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro 
        435                 440                 445             


Pro Ile Glu Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
    450                 455                 460                 


Leu Thr Arg Asp Gly Gly Asn Asn Asn Lys Thr Asn Gly Thr Glu Ile 
465                 470                 475                 480 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                485                 490                 495     


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr 
            500                 505                 510         


Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Val Gly Ala Met Phe 
    530                 535                 540                 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
545                 550                 555                 560 


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
                565                 570                 575     


Gln Asn Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln 
            580                 585                 590         


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
        595                 600                 605             


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
    610                 615                 620                 


Gly Lys Leu Ile Cys Cys Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
625                 630                 635                 640 


Asn Lys Ser Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp 
                645                 650                 655     


Glu Arg Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu 
            660                 665                 670         


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
        675                 680                 685             


Asp Lys Trp Ala Gly Leu Trp Asn Trp Phe Glu Ile Thr Asn Trp Leu 
    690                 695                 700                 


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu 
705                 710                 715                 720 


Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly 
                725                 730                 735     


Tyr Ser Pro Val Ser Phe Gln Thr His Leu Pro Ala Pro Arg Gly Pro 
            740                 745                 750         


Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Gly 
        755                 760                 765             


Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala Leu Ile Trp Asp Asp 
    770                 775                 780                 


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu 
785                 790                 795                 800 


Leu Ile Ile Ala Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu 
                805                 810                 815     


Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu 
            820                 825                 830         


Lys Asn Ser Ala Val Asn Leu Leu Asp Ala Thr Ala Ile Ala Val Ala 
        835                 840                 845             


Glu Gly Thr Asp Arg Ile Ile Glu Val Val Arg Arg Ala Phe Arg Ala 
    850                 855                 860                 


Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu 
865                 870                 875                 880 


Leu 
    


<210>  46
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Glu Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Glu Cys His Asp Val 
        115                 120                 125             


Asn Val Asn Gly Thr Ala Asn Asn Gly Thr Thr Asn Val Thr Glu Ser 
    130                 135                 140                 


Gly Val Asn Ser Ser Asp Val Thr Ser Asn Asn Val Thr Asn Ser Asn 
145                 150                 155                 160 


Trp Gly Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
                165                 170                 175     


Thr Thr Asn Ile Arg Asp Lys Met Gln Lys Glu Thr Ala Gln Phe Tyr 
            180                 185                 190         


Lys Leu Asp Ile Val Pro Ile Glu Asp Gln Asn Lys Thr Asn Asn Thr 
        195                 200                 205             


Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Cys Thr Gln Ala Cys 
    210                 215                 220                 


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
225                 230                 235                 240 


Gly Phe Ala Ile Leu Lys Cys Asn Asp Arg Asn Phe Asn Gly Thr Gly 
                245                 250                 255     


Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
            260                 265                 270         


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Ala Glu 
        275                 280                 285             


Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile 
    290                 295                 300                 


Ile Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
305                 310                 315                 320 


Asn Thr Ser Lys Arg Ile Ser Ile Gly Pro Gly Arg Ala Phe Arg Ala 
                325                 330                 335     


Thr Lys Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile Ser Arg 
            340                 345                 350         


Ala Thr Trp Asn Ser Thr Leu Lys Lys Ile Val Ala Lys Leu Arg Glu 
        355                 360                 365             


Gln Phe Gly Asn Lys Thr Ile Val Phe Gln Pro Ser Ser Gly Gly Asp 
    370                 375                 380                 


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
385                 390                 395                 400 


Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Ser Thr Glu Glu 
                405                 410                 415     


Ser Asn Ser Thr Glu Glu Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
            420                 425                 430         


Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro 
        435                 440                 445             


Pro Ile Glu Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
    450                 455                 460                 


Leu Thr Arg Asp Gly Gly Asn Asn Asn Lys Thr Asn Gly Thr Glu Ile 
465                 470                 475                 480 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                485                 490                 495     


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr 
            500                 505                 510         


Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Val Gly Ala Met Phe 
    530                 535                 540                 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
545                 550                 555                 560 


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
                565                 570                 575     


Gln Asn Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln 
            580                 585                 590         


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
        595                 600                 605             


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
    610                 615                 620                 


Gly Lys Leu Ile Cys Cys Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
625                 630                 635                 640 


Asn Lys Ser Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp 
                645                 650                 655     


Glu Arg Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu 
            660                 665                 670         


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
        675                 680                 685             


Asp Gly Gly Ser Gly Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr 
    690                 695                 700                 


Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr 
705                 710                 715                 720 


Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly 
                725                 730                 735     


Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr 
            740                 745                 750         


Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met Asn Phe 
        755                 760                 765             


Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu 
    770                 775                 780                 


Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu 
785                 790                 795                 800 


Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser 
                805                 810                 815     


Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe 
            820                 825                 830         


Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser 
        835                 840                 845             


Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu 
    850                 855                 860                 


Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
865                 870                 875         


<210>  47
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Asn Leu Leu Thr Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Ile Ile Ile Phe Cys Ser Ala Thr Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ala Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Ser Cys Ser Asn Ala Lys Val Ser Tyr Ser Asn Ala Thr Val Asn Asn 
    130                 135                 140                 


Thr Ile Gln Asp Glu Ile Lys Asn Cys Ser Phe Asn Thr Thr Thr Val 
145                 150                 155                 160 


Leu Arg Asp Lys Arg Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp 
                165                 170                 175     


Ile Val Gln Ile Asp Asn Ser Ser Ser Asp Ser Ser Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Lys Arg Glu Val Lys 
            260                 265                 270         


Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile Ile Val Gln 
        275                 280                 285             


Phe Val Asp Pro Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Ser 
                325                 330                 335     


Ser Trp Asn Lys Thr Leu Gln Gln Val Ala Lys Gln Leu Gly Thr Tyr 
            340                 345                 350         


Phe Lys Asn Lys Thr Ile Val Phe Asn Thr Ser Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Ala Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asp Thr Ser Gly Leu Phe Asn Ser Ser Trp Asn Asp Thr Thr Trp Lys 
385                 390                 395                 400 


Glu Ser Asn Ser Thr Gly Ser Asn Asp Thr Ile Thr Leu Leu Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Thr Gly Gln Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Pro Gly Leu Ile Ser Cys Lys Ser Asn Ile Thr Gly 
        435                 440                 445             


Ile Ile Leu Thr Arg Asp Gly Gly Asn Ser His Arg Thr Glu Glu Thr 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
465                 470                 475                 480 


Tyr Arg Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr 
                485                 490                 495     


Arg Ala Arg Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile 
            500                 505                 510         


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
        595                 600                 605             


Ser Ser Trp Ser Asn Lys Ser Tyr Asn Asp Ile Trp Asp Asn Met Thr 
    610                 615                 620                 


Trp Leu Gln Trp Asp Lys Glu Ile His Asn Tyr Thr Gln Leu Ile Tyr 
625                 630                 635                 640 


Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Asn Ile 
            660                 665                 670         


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Val Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro Asn 
705                 710                 715                 720 


Pro Arg Asp Leu Asp Arg Pro Glu Arg Ile Glu Glu Glu Gly Gly Glu 
                725                 730                 735     


Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu 
            740                 745                 750         


Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu 
        755                 760                 765             


Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly Gln 
    770                 775                 780                 


Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Ser Leu Lys Tyr Leu 
785                 790                 795                 800 


Trp Asn Leu Leu Gly Tyr Trp Val Arg Glu Leu Lys Ile Ser Ala Val 
                805                 810                 815     


Asn Leu Val Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg 
            820                 825                 830         


Val Ile Glu Ile Gly Gln Arg Ile Gly Arg Ala Ile Arg His Ile Pro 
        835                 840                 845             


Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860 


<210>  48
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Asp Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Ala Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Ser Cys Ser Asn Ala 
        115                 120                 125             


Lys Val Ser Tyr Ser Asn Ala Thr Val Asn Asn Thr Ile Gln Asp Glu 
    130                 135                 140                 


Ile Lys Asn Cys Ser Phe Asn Thr Thr Thr Val Leu Arg Asp Lys Arg 
145                 150                 155                 160 


Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile Val Gln Ile Asp 
                165                 170                 175     


Asn Ser Ser Ser Asp Ser Ser Ser Ser Glu Tyr Arg Leu Ile Asn Cys 
            180                 185                 190         


Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Lys Arg Glu Val Lys Ile Arg Ser Glu Asn 
            260                 265                 270         


Ile Thr Asn Asn Ala Lys Asn Ile Ile Val Gln Phe Val Asp Pro Val 
        275                 280                 285             


Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His 
    290                 295                 300                 


Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Val Ser Arg Ser Ser Trp Asn Lys Thr 
                325                 330                 335     


Leu Gln Gln Val Ala Lys Gln Leu Gly Thr Tyr Phe Lys Asn Lys Thr 
            340                 345                 350         


Ile Val Phe Asn Thr Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Ala Gly Glu Phe Phe Tyr Cys Asp Thr Ser Gly Leu 
    370                 375                 380                 


Phe Asn Ser Ser Trp Asn Asp Thr Thr Trp Lys Glu Ser Asn Ser Thr 
385                 390                 395                 400 


Gly Ser Asn Asp Thr Ile Thr Leu Leu Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala Pro Pro Ile Pro 
            420                 425                 430         


Gly Leu Ile Ser Cys Lys Ser Asn Ile Thr Gly Ile Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asn Ser His Arg Thr Glu Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Arg Tyr Lys Val 
465                 470                 475                 480 


Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Arg Arg Arg 
                485                 490                 495     


Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Tyr Asn Asp 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile His Asn 
625                 630                 635                 640 


Tyr Thr Gln Leu Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
            660                 665         


<210>  49
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Asp Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Ala Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Ser Cys Ser Asn Ala 
        115                 120                 125             


Lys Val Ser Tyr Ser Asn Ala Thr Val Asn Asn Thr Ile Gln Asp Glu 
    130                 135                 140                 


Ile Lys Asn Cys Ser Phe Asn Thr Thr Thr Val Leu Arg Asp Lys Arg 
145                 150                 155                 160 


Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile Val Gln Ile Asp 
                165                 170                 175     


Asn Ser Ser Ser Asp Ser Ser Ser Ser Glu Tyr Arg Leu Ile Asn Cys 
            180                 185                 190         


Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Lys Arg Glu Val Lys Ile Arg Ser Glu Asn 
            260                 265                 270         


Ile Thr Asn Asn Ala Lys Asn Ile Ile Val Gln Phe Val Asp Pro Val 
        275                 280                 285             


Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His 
    290                 295                 300                 


Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Val Ser Arg Ser Ser Trp Asn Lys Thr 
                325                 330                 335     


Leu Gln Gln Val Ala Lys Gln Leu Gly Thr Tyr Phe Lys Asn Lys Thr 
            340                 345                 350         


Ile Val Phe Asn Thr Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Ala Gly Glu Phe Phe Tyr Cys Asp Thr Ser Gly Leu 
    370                 375                 380                 


Phe Asn Ser Ser Trp Asn Asp Thr Thr Trp Lys Glu Ser Asn Ser Thr 
385                 390                 395                 400 


Gly Ser Asn Asp Thr Ile Thr Leu Leu Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala Pro Pro Ile Pro 
            420                 425                 430         


Gly Leu Ile Ser Cys Lys Ser Asn Ile Thr Gly Ile Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asn Ser His Arg Thr Glu Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Arg Tyr Lys Val 
465                 470                 475                 480 


Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Arg Arg Arg 
                485                 490                 495     


Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Tyr Asn Asp 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile His Asn 
625                 630                 635                 640 


Tyr Thr Gln Leu Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu 
            660                 665                 670         


Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe 
        675                 680                 685             


Ile Met Val Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val 
    690                 695                 700                 


Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe 
705                 710                 715                 720 


Gln Thr His Leu Pro Asn Pro Arg Asp Leu Asp Arg Pro Glu Arg Ile 
                725                 730                 735     


Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val 
            740                 745                 750         


Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu 
        755                 760                 765             


Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr 
    770                 775                 780                 


Val Glu Leu Leu Gly Gln Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp 
785                 790                 795                 800 


Glu Ser Leu Lys Tyr Leu Trp Asn Leu Leu Gly Tyr Trp Val Arg Glu 
                805                 810                 815     


Leu Lys Ile Ser Ala Val Asn Leu Val Asp Thr Ile Ala Ile Ala Val 
            820                 825                 830         


Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Arg Ile Gly Arg 
        835                 840                 845             


Ala Ile Arg His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala 
    850                 855                 860                 


Leu Leu 
865     


<210>  50
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Asp Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Ala Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Ser Cys Ser Asn Ala 
        115                 120                 125             


Lys Val Ser Tyr Ser Asn Ala Thr Val Asn Asn Thr Ile Gln Asp Glu 
    130                 135                 140                 


Ile Lys Asn Cys Ser Phe Asn Thr Thr Thr Val Leu Arg Asp Lys Arg 
145                 150                 155                 160 


Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile Val Gln Ile Asp 
                165                 170                 175     


Asn Ser Ser Ser Asp Ser Ser Ser Ser Glu Tyr Arg Leu Ile Asn Cys 
            180                 185                 190         


Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Lys Arg Glu Val Lys Ile Arg Ser Glu Asn 
            260                 265                 270         


Ile Thr Asn Asn Ala Lys Asn Ile Ile Val Gln Phe Val Asp Pro Val 
        275                 280                 285             


Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His 
    290                 295                 300                 


Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Val Ser Arg Ser Ser Trp Asn Lys Thr 
                325                 330                 335     


Leu Gln Gln Val Ala Lys Gln Leu Gly Thr Tyr Phe Lys Asn Lys Thr 
            340                 345                 350         


Ile Val Phe Asn Thr Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Ala Gly Glu Phe Phe Tyr Cys Asp Thr Ser Gly Leu 
    370                 375                 380                 


Phe Asn Ser Ser Trp Asn Asp Thr Thr Trp Lys Glu Ser Asn Ser Thr 
385                 390                 395                 400 


Gly Ser Asn Asp Thr Ile Thr Leu Leu Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala Pro Pro Ile Pro 
            420                 425                 430         


Gly Leu Ile Ser Cys Lys Ser Asn Ile Thr Gly Ile Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asn Ser His Arg Thr Glu Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Arg Tyr Lys Val 
465                 470                 475                 480 


Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Arg Arg Arg 
                485                 490                 495     


Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Tyr Asn Asp 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile His Asn 
625                 630                 635                 640 


Tyr Thr Gln Leu Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Gly Ser Gly Gly 
            660                 665                 670         


Glu Tyr Gly Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala 
        675                 680                 685             


Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr 
    690                 695                 700                 


Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys 
705                 710                 715                 720 


Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His 
                725                 730                 735     


Val Thr Lys Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met 
            740                 745                 750         


Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala 
        755                 760                 765             


Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe 
    770                 775                 780                 


Tyr Ile His Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro 
785                 790                 795                 800 


Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu 
                805                 810                 815     


Lys Ile Arg Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile 
            820                 825                 830         


Thr Ala Asn Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp 
        835                 840                 845             


Glu Tyr Leu Gln Lys Thr Val 
    850                 855 


<210>  51
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Met Arg Val Met Gly Thr Gln Arg Asn Cys Gln His Leu Leu Thr Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Ile Ile Ile Ile Cys Ser Thr Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Ala Asn Val Thr Ser Glu Asn Ser Thr Ile Met Gly 
    130                 135                 140                 


Asp Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu 
145                 150                 155                 160 


Arg Asp Lys Arg Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val 
                165                 170                 175     


Val Gln Ile Asn Glu Asn Gln Gly Asn Ser Ser Asn Asn Asn Tyr Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Leu Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Thr Ala Glu Lys Glu 
            260                 265                 270         


Ile Lys Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Ile Ile Ile 
        275                 280                 285             


Val Gln Leu Val Lys Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Arg Ser Val His Ile Gly Pro Gly Gln Ala Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asn Ile Arg Gln Ala Tyr Cys Thr Val Asn 
                325                 330                 335     


Arg Thr Asp Trp Asn Asn Thr Leu Gln Gln Val Ala Lys Gln Leu Gly 
            340                 345                 350         


Lys His Phe Glu Asn Lys Thr Ile Ile Phe Thr Lys Ser Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Ser Ser Leu Phe Asn Ser Thr Trp Ser His Asn Asn 
385                 390                 395                 400 


Ser Thr Leu Leu Gly Ser Asn Ser Thr Glu Ser Asn Glu Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp Gln Arg Thr Gly 
            420                 425                 430         


Gln Ala Met Tyr Ala Pro Pro Ile Lys Gly Val Ile Met Cys Val Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Asp Asn Ser 
    450                 455                 460                 


Thr Asn Glu Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro 
                485                 490                 495     


Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg Val Val Glu Arg Glu 
            500                 505                 510         


Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Arg Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
        595                 600                 605             


Thr Ser Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Leu Asp Glu 
    610                 615                 620                 


Ile Trp Glu Asn Met Thr Trp Leu Gln Trp Glu Lys Glu Ile Asn Asn 
625                 630                 635                 640 


Tyr Thr Gly Leu Ile Tyr Ser Leu Leu Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu 
            660                 665                 670         


Trp Thr Trp Phe Gly Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe 
        675                 680                 685             


Ile Ile Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val 
    690                 695                 700                 


Leu Ser Val Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe 
705                 710                 715                 720 


Gln Ile His Pro Pro Asn Pro Gly Gly Leu Asp Arg Pro Gly Arg Ile 
                725                 730                 735     


Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val 
            740                 745                 750         


Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu 
        755                 760                 765             


Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr 
    770                 775                 780                 


Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp 
785                 790                 795                 800 


Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Ala Tyr Trp Gly Arg Glu 
                805                 810                 815     


Leu Lys Ile Ser Ala Ile Ser Leu Val Asp Asn Ile Ala Ile Val Val 
            820                 825                 830         


Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Gly Ile Gly Arg 
        835                 840                 845             


Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala 
    850                 855                 860                 


Leu Leu 
865     


<210>  52
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Asp Leu 
65                  70                  75                  80  


Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asn Ala 
        115                 120                 125             


Asn Val Thr Ser Glu Asn Ser Thr Ile Met Gly Asp Arg Glu Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu 
                165                 170                 175     


Asn Gln Gly Asn Ser Ser Asn Asn Asn Tyr Ser Glu Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Thr Ala Glu Lys Glu Ile Lys Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Val Lys 
        275                 280                 285             


Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser 
    290                 295                 300                 


Val His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Thr Val Asn Arg Thr Asp Trp Asn 
                325                 330                 335     


Asn Thr Leu Gln Gln Val Ala Lys Gln Leu Gly Lys His Phe Glu Asn 
            340                 345                 350         


Lys Thr Ile Ile Phe Thr Lys Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asn Ser Thr Trp Ser His Asn Asn Ser Thr Leu Leu Gly 
385                 390                 395                 400 


Ser Asn Ser Thr Glu Ser Asn Glu Thr Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Val Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Lys Gly Val Ile Met Cys Val Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Ile Leu Thr Arg Asp Gly Gly Asn Asp Asn Ser Thr Asn Glu Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Arg Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
            580                 585                 590         


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Leu Asp Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Glu Lys Glu Ile Asn Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp 
    


<210>  53
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Asp Leu 
65                  70                  75                  80  


Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asn Ala 
        115                 120                 125             


Asn Val Thr Ser Glu Asn Ser Thr Ile Met Gly Asp Arg Glu Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu 
                165                 170                 175     


Asn Gln Gly Asn Ser Ser Asn Asn Asn Tyr Ser Glu Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Thr Ala Glu Lys Glu Ile Lys Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Val Lys 
        275                 280                 285             


Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser 
    290                 295                 300                 


Val His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Thr Val Asn Arg Thr Asp Trp Asn 
                325                 330                 335     


Asn Thr Leu Gln Gln Val Ala Lys Gln Leu Gly Lys His Phe Glu Asn 
            340                 345                 350         


Lys Thr Ile Ile Phe Thr Lys Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asn Ser Thr Trp Ser His Asn Asn Ser Thr Leu Leu Gly 
385                 390                 395                 400 


Ser Asn Ser Thr Glu Ser Asn Glu Thr Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Val Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Lys Gly Val Ile Met Cys Val Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Ile Leu Thr Arg Asp Gly Gly Asn Asp Asn Ser Thr Asn Glu Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Arg Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
            580                 585                 590         


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Leu Asp Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Glu Lys Glu Ile Asn Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Lys Trp Ala Asn Leu Trp Thr Trp Phe Gly Ile Ser Asn Trp Leu 
        675                 680                 685             


Trp Tyr Ile Arg Ile Phe Ile Ile Ile Val Gly Gly Leu Ile Gly Leu 
    690                 695                 700                 


Arg Ile Val Phe Ala Val Leu Ser Val Val Asn Arg Val Arg Gln Gly 
705                 710                 715                 720 


Tyr Ser Pro Leu Ser Phe Gln Ile His Pro Pro Asn Pro Gly Gly Leu 
                725                 730                 735     


Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp 
            740                 745                 750         


Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp 
        755                 760                 765             


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile 
    770                 775                 780                 


Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys 
785                 790                 795                 800 


Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu 
                805                 810                 815     


Ala Tyr Trp Gly Arg Glu Leu Lys Ile Ser Ala Ile Ser Leu Val Asp 
            820                 825                 830         


Asn Ile Ala Ile Val Val Ala Gly Trp Thr Asp Arg Val Ile Glu Ile 
        835                 840                 845             


Gly Gln Gly Ile Gly Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg 
    850                 855                 860                 


Gln Gly Phe Glu Arg Ala Leu Leu 
865                 870         


<210>  54
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Asp Leu 
65                  70                  75                  80  


Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asn Ala 
        115                 120                 125             


Asn Val Thr Ser Glu Asn Ser Thr Ile Met Gly Asp Arg Glu Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu 
                165                 170                 175     


Asn Gln Gly Asn Ser Ser Asn Asn Asn Tyr Ser Glu Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Thr Ala Glu Lys Glu Ile Lys Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Val Lys 
        275                 280                 285             


Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser 
    290                 295                 300                 


Val His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Thr Val Asn Arg Thr Asp Trp Asn 
                325                 330                 335     


Asn Thr Leu Gln Gln Val Ala Lys Gln Leu Gly Lys His Phe Glu Asn 
            340                 345                 350         


Lys Thr Ile Ile Phe Thr Lys Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asn Ser Thr Trp Ser His Asn Asn Ser Thr Leu Leu Gly 
385                 390                 395                 400 


Ser Asn Ser Thr Glu Ser Asn Glu Thr Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Val Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Lys Gly Val Ile Met Cys Val Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Ile Leu Thr Arg Asp Gly Gly Asn Asp Asn Ser Thr Asn Glu Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Arg Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
            580                 585                 590         


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Leu Asp Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Glu Lys Glu Ile Asn Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Gly Gly Ser Gly Gly Arg Ser Cys Arg Asn Ser Met Arg Gln Gln 
        675                 680                 685             


Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala 
    690                 695                 700                 


His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe 
705                 710                 715                 720 


Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu 
                725                 730                 735     


Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu 
            740                 745                 750         


Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala 
        755                 760                 765             


Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg 
    770                 775                 780                 


Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His 
785                 790                 795                 800 


Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly 
                805                 810                 815     


Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp 
            820                 825                 830         


Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly 
        835                 840                 845             


Ile Asp Val 
    850     


<210>  55
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Met Arg Val Met Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Trp Leu Leu Met Ile Cys Ser Ala Ala Asp Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn His Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Val Asn Ser Asn Ile Thr Arg Val Asp Asn Thr 
    130                 135                 140                 


Thr Glu Lys Glu Met Lys Asn Cys Ser Phe Asn Val Thr Ser Gly Ile 
145                 150                 155                 160 


Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Leu Tyr Lys Leu Asp Ile 
                165                 170                 175     


Val Gln Ile Asp Asn Asp Asn Thr Ser His Arg Asp Asn Thr Ser Tyr 
            180                 185                 190         


Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Ile Ser Phe Glu Pro Ile Pro Ile His Phe Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val 
            260                 265                 270         


Ile Arg Ser Glu Asn Phe Thr Asn Asn Val Lys Asn Ile Ile Val Gln 
        275                 280                 285             


Leu Asn Glu Ser Val Gln Ile Asn Cys Thr Arg His Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Asn Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Lys Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Glu 
                325                 330                 335     


Lys Trp Gln Asn Thr Leu Lys Gln Ile Val Lys Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Lys Asn Lys Thr Ile Ala Phe Ala Pro Ser Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Val Met His Ser Phe Asn Cys Asn Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Thr Ser Thr Trp Asn Ser Thr Trp Asn Ser 
385                 390                 395                 400 


Thr Trp Asn Asn Thr Glu Gly Ser Asn Ser Thr Val Ile Thr Leu Pro 
                405                 410                 415     


Cys Arg Ile Arg Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala 
            420                 425                 430         


Met Tyr Ala Pro Pro Ile Gln Gly Gln Ile Lys Cys Ser Ser Asn Ile 
        435                 440                 445             


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Val Asp Thr Thr Lys Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp 
        595                 600                 605             


Asn Ala Ser Trp Ser Asn Lys Ser Gln Asp Thr Ile Trp Gly Asn Met 
    610                 615                 620                 


Thr Trp Met Gln Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asp Leu Ile 
625                 630                 635                 640 


Tyr Asn Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
                645                 650                 655     


Glu Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Ser 
            660                 665                 670         


Ile Thr His Trp Leu Trp Tyr Ile Lys Met Phe Ile Met Ile Val Gly 
        675                 680                 685             


Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Arg Phe Pro 
705                 710                 715                 720 


Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly 
                725                 730                 735     


Glu Arg Asp Arg Asp Arg Ser Gly Arg Ser Ala Asp Gly Phe Leu Val 
            740                 745                 750         


Leu Val Trp Val Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Thr Val Glu Leu Leu Gly 
    770                 775                 780                 


Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr 
785                 790                 795                 800 


Trp Ser Gln Glu Leu Lys Lys Ser Ala Val Ser Leu Leu Asp Ala Ile 
                805                 810                 815     


Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Leu Gln 
            820                 825                 830         


Arg Ile Phe Arg Ala Phe Leu His Ile Pro Thr Arg Ile Arg Gln Gly 
        835                 840                 845             


Leu Glu Arg Ala Leu Gln 
    850                 


<210>  56
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Asp Gln Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn His Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu 
        115                 120                 125             


Val Asn Ser Asn Ile Thr Arg Val Asp Asn Thr Thr Glu Lys Glu Met 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Val Thr Ser Gly Ile Arg Asp Lys Val Gln 
145                 150                 155                 160 


Lys Glu Tyr Ala Leu Leu Tyr Lys Leu Asp Ile Val Gln Ile Asp Asn 
                165                 170                 175     


Asp Asn Thr Ser His Arg Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys 
            180                 185                 190         


Asn Thr Ser Val Cys Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Phe Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn 
            260                 265                 270         


Phe Thr Asn Asn Val Lys Asn Ile Ile Val Gln Leu Asn Glu Ser Val 
        275                 280                 285             


Gln Ile Asn Cys Thr Arg His Asn Asn Asn Thr Arg Lys Ser Ile Asn 
    290                 295                 300                 


Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Lys Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Ile Ser Arg Glu Lys Trp Gln Asn Thr 
                325                 330                 335     


Leu Lys Gln Ile Val Lys Lys Leu Arg Glu Gln Phe Lys Asn Lys Thr 
            340                 345                 350         


Ile Ala Phe Ala Pro Ser Ser Gly Gly Asp Pro Glu Ile Val Met His 
        355                 360                 365             


Ser Phe Asn Cys Asn Gly Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu 
    370                 375                 380                 


Phe Thr Ser Thr Trp Asn Ser Thr Trp Asn Ser Thr Trp Asn Asn Thr 
385                 390                 395                 400 


Glu Gly Ser Asn Ser Thr Val Ile Thr Leu Pro Cys Arg Ile Arg Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Gln Gly Gln Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Val Asp Thr Thr Lys Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Arg Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Cys Lys Arg 
                485                 490                 495     


Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Cys Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Gln Asp 
    610                 615                 620                 


Thr Ile Trp Gly Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp 
625                 630                 635                 640 


Asn Tyr Thr Asp Leu Ile Tyr Asn Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp 
            660                 665             


<210>  57
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Asp Gln Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn His Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu 
        115                 120                 125             


Val Asn Ser Asn Ile Thr Arg Val Asp Asn Thr Thr Glu Lys Glu Met 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Val Thr Ser Gly Ile Arg Asp Lys Val Gln 
145                 150                 155                 160 


Lys Glu Tyr Ala Leu Leu Tyr Lys Leu Asp Ile Val Gln Ile Asp Asn 
                165                 170                 175     


Asp Asn Thr Ser His Arg Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys 
            180                 185                 190         


Asn Thr Ser Val Cys Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Phe Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn 
            260                 265                 270         


Phe Thr Asn Asn Val Lys Asn Ile Ile Val Gln Leu Asn Glu Ser Val 
        275                 280                 285             


Gln Ile Asn Cys Thr Arg His Asn Asn Asn Thr Arg Lys Ser Ile Asn 
    290                 295                 300                 


Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Lys Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Ile Ser Arg Glu Lys Trp Gln Asn Thr 
                325                 330                 335     


Leu Lys Gln Ile Val Lys Lys Leu Arg Glu Gln Phe Lys Asn Lys Thr 
            340                 345                 350         


Ile Ala Phe Ala Pro Ser Ser Gly Gly Asp Pro Glu Ile Val Met His 
        355                 360                 365             


Ser Phe Asn Cys Asn Gly Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu 
    370                 375                 380                 


Phe Thr Ser Thr Trp Asn Ser Thr Trp Asn Ser Thr Trp Asn Asn Thr 
385                 390                 395                 400 


Glu Gly Ser Asn Ser Thr Val Ile Thr Leu Pro Cys Arg Ile Arg Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Gln Gly Gln Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Val Asp Thr Thr Lys Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Arg Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Cys Lys Arg 
                485                 490                 495     


Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Cys Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Gln Asp 
    610                 615                 620                 


Thr Ile Trp Gly Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp 
625                 630                 635                 640 


Asn Tyr Thr Asp Leu Ile Tyr Asn Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp Lys Trp Ala Ser 
            660                 665                 670         


Leu Trp Ser Trp Phe Ser Ile Thr His Trp Leu Trp Tyr Ile Lys Met 
        675                 680                 685             


Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala 
    690                 695                 700                 


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
705                 710                 715                 720 


Phe Gln Thr Arg Phe Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly 
                725                 730                 735     


Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Gly Arg Ser 
            740                 745                 750         


Ala Asp Gly Phe Leu Val Leu Val Trp Val Asp Leu Arg Asn Leu Cys 
        755                 760                 765             


Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg 
    770                 775                 780                 


Thr Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp 
785                 790                 795                 800 


Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Lys Ser Ala Val 
                805                 810                 815     


Ser Leu Leu Asp Ala Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
            820                 825                 830         


Ile Ile Glu Leu Leu Gln Arg Ile Phe Arg Ala Phe Leu His Ile Pro 
        835                 840                 845             


Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Gln 
    850                 855                 860 


<210>  58
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Asp Gln Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn His Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu 
        115                 120                 125             


Val Asn Ser Asn Ile Thr Arg Val Asp Asn Thr Thr Glu Lys Glu Met 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Val Thr Ser Gly Ile Arg Asp Lys Val Gln 
145                 150                 155                 160 


Lys Glu Tyr Ala Leu Leu Tyr Lys Leu Asp Ile Val Gln Ile Asp Asn 
                165                 170                 175     


Asp Asn Thr Ser His Arg Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys 
            180                 185                 190         


Asn Thr Ser Val Cys Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Phe Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn 
            260                 265                 270         


Phe Thr Asn Asn Val Lys Asn Ile Ile Val Gln Leu Asn Glu Ser Val 
        275                 280                 285             


Gln Ile Asn Cys Thr Arg His Asn Asn Asn Thr Arg Lys Ser Ile Asn 
    290                 295                 300                 


Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Lys Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Ile Ser Arg Glu Lys Trp Gln Asn Thr 
                325                 330                 335     


Leu Lys Gln Ile Val Lys Lys Leu Arg Glu Gln Phe Lys Asn Lys Thr 
            340                 345                 350         


Ile Ala Phe Ala Pro Ser Ser Gly Gly Asp Pro Glu Ile Val Met His 
        355                 360                 365             


Ser Phe Asn Cys Asn Gly Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu 
    370                 375                 380                 


Phe Thr Ser Thr Trp Asn Ser Thr Trp Asn Ser Thr Trp Asn Asn Thr 
385                 390                 395                 400 


Glu Gly Ser Asn Ser Thr Val Ile Thr Leu Pro Cys Arg Ile Arg Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Gln Gly Gln Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Val Asp Thr Thr Lys Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Arg Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Cys Lys Arg 
                485                 490                 495     


Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Cys Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Gln Asp 
    610                 615                 620                 


Thr Ile Trp Gly Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp 
625                 630                 635                 640 


Asn Tyr Thr Asp Leu Ile Tyr Asn Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp Gly Gly Ser Gly 
            660                 665                 670         


Gly Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val 
        675                 680                 685             


Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp 
    690                 695                 700                 


Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser 
705                 710                 715                 720 


Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg 
                725                 730                 735     


Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro 
            740                 745                 750         


Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu 
        755                 760                 765             


Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala 
    770                 775                 780                 


Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu 
785                 790                 795                 800 


Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala 
                805                 810                 815     


Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu 
            820                 825                 830         


Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
        835                 840                 845     


<210>  59
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Met Arg Val Arg Gly Ile Gln Thr Ser Trp Gln Asn Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Leu Met Ile Tyr Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Asn Ala Thr Ala Ser Asn Val Thr Asn Glu Met Arg Asn Cys 
    130                 135                 140                 


Ser Phe Asn Ile Thr Thr Glu Leu Lys Asp Lys Lys Gln Gln Val Tyr 
145                 150                 155                 160 


Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn Glu Lys Asn Glu 
                165                 170                 175     


Thr Asp Lys Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Phe Ala Val Leu Lys Cys Lys Asp Thr Glu Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Arg Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Glu Gly Ile Gln Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr 
            260                 265                 270         


Ile Ile Val Gln Leu Asp Lys Ala Val Lys Ile Asn Cys Thr Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Gly Val Arg Ile Gly Pro Gly Gln Ala Phe 
    290                 295                 300                 


Tyr Ala Thr Gly Gly Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
305                 310                 315                 320 


Val Ser Arg Ala Lys Trp Asn Asp Thr Leu Arg Gly Val Ala Lys Lys 
                325                 330                 335     


Leu Arg Glu His Phe Lys Asn Lys Thr Ile Ile Phe Glu Lys Ser Ser 
            340                 345                 350         


Gly Gly Asp Ile Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
        355                 360                 365             


Phe Phe Tyr Cys Ser Thr Ser Gly Leu Phe Asn Ser Thr Trp Glu Ser 
    370                 375                 380                 


Asn Ser Thr Glu Ser Asn Asn Thr Thr Ser Asn Asp Thr Ile Thr Leu 
385                 390                 395                 400 


Thr Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Gln 
                405                 410                 415     


Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Glu Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn 
        435                 440                 445             


Glu Ile Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser 
    450                 455                 460                 


Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala 
465                 470                 475                 480 


Pro Ser Arg Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
                485                 490                 495     


Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
            500                 505                 510         


Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln Ala Arg Gln Leu Leu 
        515                 520                 525             


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
    530                 535                 540                 


Gln Gln His Met Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
545                 550                 555                 560 


Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
                565                 570                 575     


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro 
            580                 585                 590         


Trp Asn Ser Ser Trp Ser Asn Lys Ser Met Asn Glu Ile Trp Asp Asn 
        595                 600                 605             


Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile 
    610                 615                 620                 


Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
625                 630                 635                 640 


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
                645                 650                 655     


Asp Ile Ser Arg Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
            660                 665                 670         


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Val Ile 
        675                 680                 685             


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Ile Arg Thr 
    690                 695                 700                 


Pro Asn Pro Lys Glu Pro Asp Arg Leu Gly Arg Ile Asp Gly Glu Gly 
705                 710                 715                 720 


Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
                725                 730                 735     


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
            740                 745                 750         


Arg Leu Arg Asp Phe Ile Ser Ile Ala Ala Arg Thr Val Glu Leu Leu 
        755                 760                 765             


Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys 
    770                 775                 780                 


Tyr Leu Trp Asn Leu Leu Leu Tyr Trp Gly Arg Glu Leu Lys Thr Ser 
785                 790                 795                 800 


Ala Val Asn Leu Val Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Ala 
                805                 810                 815     


Asp Arg Val Met Glu Val Gly Gln Arg Ile Phe Arg Ala Ile Leu Asn 
            820                 825                 830         


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Gly Leu Leu 
        835                 840                 845     


<210>  60
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Glu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln 
                85                  90                  95      


Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asp Cys Asn Ala Thr Ala 
        115                 120                 125             


Ser Asn Val Thr Asn Glu Met Arg Asn Cys Ser Phe Asn Ile Thr Thr 
    130                 135                 140                 


Glu Leu Lys Asp Lys Lys Gln Gln Val Tyr Ser Leu Phe Tyr Lys Leu 
145                 150                 155                 160 


Asp Val Val Gln Ile Asn Glu Lys Asn Glu Thr Asp Lys Tyr Arg Leu 
                165                 170                 175     


Ile Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser 
            180                 185                 190         


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Val 
        195                 200                 205             


Leu Lys Cys Lys Asp Thr Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn 
    210                 215                 220                 


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Ile Ser Thr 
225                 230                 235                 240 


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly Ile Gln Ile Arg 
                245                 250                 255     


Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asp 
            260                 265                 270         


Lys Ala Val Lys Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
        275                 280                 285             


Gly Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Gly Ile 
    290                 295                 300                 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Ala Lys Trp 
305                 310                 315                 320 


Asn Asp Thr Leu Arg Gly Val Ala Lys Lys Leu Arg Glu His Phe Lys 
                325                 330                 335     


Asn Lys Thr Ile Ile Phe Glu Lys Ser Ser Gly Gly Asp Ile Glu Ile 
            340                 345                 350         


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Ser Thr 
        355                 360                 365             


Ser Gly Leu Phe Asn Ser Thr Trp Glu Ser Asn Ser Thr Glu Ser Asn 
    370                 375                 380                 


Asn Thr Thr Ser Asn Asp Thr Ile Thr Leu Thr Cys Arg Ile Lys Gln 
385                 390                 395                 400 


Ile Ile Asn Met Trp Gln Lys Val Gly Gln Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Ser Arg Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Lys Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Met Asn 
        595                 600                 605             


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Gln Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650         


<210>  61
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Glu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln 
                85                  90                  95      


Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asp Cys Asn Ala Thr Ala 
        115                 120                 125             


Ser Asn Val Thr Asn Glu Met Arg Asn Cys Ser Phe Asn Ile Thr Thr 
    130                 135                 140                 


Glu Leu Lys Asp Lys Lys Gln Gln Val Tyr Ser Leu Phe Tyr Lys Leu 
145                 150                 155                 160 


Asp Val Val Gln Ile Asn Glu Lys Asn Glu Thr Asp Lys Tyr Arg Leu 
                165                 170                 175     


Ile Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser 
            180                 185                 190         


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Val 
        195                 200                 205             


Leu Lys Cys Lys Asp Thr Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn 
    210                 215                 220                 


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Ile Ser Thr 
225                 230                 235                 240 


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly Ile Gln Ile Arg 
                245                 250                 255     


Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asp 
            260                 265                 270         


Lys Ala Val Lys Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
        275                 280                 285             


Gly Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Gly Ile 
    290                 295                 300                 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Ala Lys Trp 
305                 310                 315                 320 


Asn Asp Thr Leu Arg Gly Val Ala Lys Lys Leu Arg Glu His Phe Lys 
                325                 330                 335     


Asn Lys Thr Ile Ile Phe Glu Lys Ser Ser Gly Gly Asp Ile Glu Ile 
            340                 345                 350         


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Ser Thr 
        355                 360                 365             


Ser Gly Leu Phe Asn Ser Thr Trp Glu Ser Asn Ser Thr Glu Ser Asn 
    370                 375                 380                 


Asn Thr Thr Ser Asn Asp Thr Ile Thr Leu Thr Cys Arg Ile Lys Gln 
385                 390                 395                 400 


Ile Ile Asn Met Trp Gln Lys Val Gly Gln Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Ser Arg Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Lys Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Met Asn 
        595                 600                 605             


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Gln Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser 
                645                 650                 655     


Leu Trp Asn Trp Phe Asp Ile Ser Arg Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
        675                 680                 685             


Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Ile Arg Thr Pro Asn Pro Lys Glu Pro Asp Arg Leu Gly Arg 
705                 710                 715                 720 


Ile Asp Gly Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu 
                725                 730                 735     


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Ser Ile Ala Ala Arg 
        755                 760                 765             


Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly 
    770                 775                 780                 


Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Leu Tyr Trp Gly Arg 
785                 790                 795                 800 


Glu Leu Lys Thr Ser Ala Val Asn Leu Val Asp Thr Ile Ala Ile Ala 
                805                 810                 815     


Val Ala Gly Trp Ala Asp Arg Val Met Glu Val Gly Gln Arg Ile Phe 
            820                 825                 830         


Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg 
        835                 840                 845             


Gly Leu Leu 
    850     


<210>  62
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Glu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln 
                85                  90                  95      


Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asp Cys Asn Ala Thr Ala 
        115                 120                 125             


Ser Asn Val Thr Asn Glu Met Arg Asn Cys Ser Phe Asn Ile Thr Thr 
    130                 135                 140                 


Glu Leu Lys Asp Lys Lys Gln Gln Val Tyr Ser Leu Phe Tyr Lys Leu 
145                 150                 155                 160 


Asp Val Val Gln Ile Asn Glu Lys Asn Glu Thr Asp Lys Tyr Arg Leu 
                165                 170                 175     


Ile Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser 
            180                 185                 190         


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Val 
        195                 200                 205             


Leu Lys Cys Lys Asp Thr Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn 
    210                 215                 220                 


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Ile Ser Thr 
225                 230                 235                 240 


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly Ile Gln Ile Arg 
                245                 250                 255     


Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asp 
            260                 265                 270         


Lys Ala Val Lys Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
        275                 280                 285             


Gly Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Gly Ile 
    290                 295                 300                 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Ala Lys Trp 
305                 310                 315                 320 


Asn Asp Thr Leu Arg Gly Val Ala Lys Lys Leu Arg Glu His Phe Lys 
                325                 330                 335     


Asn Lys Thr Ile Ile Phe Glu Lys Ser Ser Gly Gly Asp Ile Glu Ile 
            340                 345                 350         


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Ser Thr 
        355                 360                 365             


Ser Gly Leu Phe Asn Ser Thr Trp Glu Ser Asn Ser Thr Glu Ser Asn 
    370                 375                 380                 


Asn Thr Thr Ser Asn Asp Thr Ile Thr Leu Thr Cys Arg Ile Lys Gln 
385                 390                 395                 400 


Ile Ile Asn Met Trp Gln Lys Val Gly Gln Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Ser Arg Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Lys Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Met Asn 
        595                 600                 605             


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Gln Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Gly Ser Gly 
                645                 650                 655     


Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr 
            660                 665                 670         


Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala 
        675                 680                 685             


Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe 
    690                 695                 700                 


Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys 
705                 710                 715                 720 


His Val Thr Lys Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr 
                725                 730                 735     


Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu 
            740                 745                 750         


Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala 
        755                 760                 765             


Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp 
    770                 775                 780                 


Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala 
785                 790                 795                 800 


Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe 
                805                 810                 815     


Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe 
            820                 825                 830         


Asp Glu Tyr Leu Gln Lys Thr Val 
        835                 840 


<210>  63
<211>  841
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Met Arg Val Arg Gly Ile Ser Arg Asn Trp Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Val Leu Gly Phe Trp Leu Leu Met Ser Tyr Ser Val Leu Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Ser Val Asn Ala Thr Tyr Asn Gly Glu Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Ala Thr Thr Ala Ile Arg Asp Lys Lys Gln Gln 
145                 150                 155                 160 


Val Arg Ala Leu Phe Tyr Ser Leu Asp Ile Val Pro Leu Glu Gly Asn 
                165                 170                 175     


Asn Ser Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Ala Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Thr 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Glu Lys Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys His Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Lys Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr 
            260                 265                 270         


Ile Ile Val His Leu Asn Lys Ala Val Glu Ile Val Cys Val Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Asn Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile 
305                 310                 315                 320 


Ser Glu Ser Lys Trp Asn Asp Thr Leu Arg Gln Val Gly Ala Lys Leu 
                325                 330                 335     


Ala Glu His Phe Asn Asn Asn Thr Ile Arg Phe Glu Pro Ser Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly Thr Tyr Asn His Thr 
    370                 375                 380                 


Asp Thr Gly Gly Asn Ser Thr Asn Ile Thr Leu Pro Cys Arg Ile Lys 
385                 390                 395                 400 


Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Ile Tyr Ala Pro 
                405                 410                 415     


Pro Val Glu Gly Asn Ile Ile Cys Ile Ser Asn Ile Thr Gly Leu Leu 
            420                 425                 430         


Leu Leu Arg Asp Gly Gly His Asn Ser Thr Asn Glu Thr Phe Arg Pro 
        435                 440                 445             


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
    450                 455                 460                 


Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Glu Ala Lys 
465                 470                 475                 480 


Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Met 
                485                 490                 495     


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
            500                 505                 510         


Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
        515                 520                 525             


Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu 
    530                 535                 540                 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ser 
545                 550                 555                 560 


Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys 
                565                 570                 575     


Ser Gly Lys Leu Ile Cys Thr Thr Ser Val Pro Trp Asn His Ser Trp 
            580                 585                 590         


Ser Asn Lys Ser Gln Lys Asp Ile Trp Glu Asn Met Thr Trp Met Gln 
        595                 600                 605             


Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Ser Leu Leu 
    610                 615                 620                 


Glu Glu Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala 
625                 630                 635                 640 


Leu Asp Asn Trp Asn Asn Leu Trp Asn Trp Phe Ser Ile Thr Lys Trp 
                645                 650                 655     


Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly Leu Ile Gly 
            660                 665                 670         


Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln 
        675                 680                 685             


Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Ile Pro Ser Pro Arg Gly 
    690                 695                 700                 


Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys 
705                 710                 715                 720 


Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ser Leu Ala Trp Asp 
                725                 730                 735     


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe 
            740                 745                 750         


Leu Leu Val Thr Ala Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu 
        755                 760                 765             


Lys Gly Leu Gln Lys Gly Trp Glu Ala Leu Lys Tyr Leu Gly Asn Leu 
    770                 775                 780                 


Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Val Ile Ser Leu Ile 
785                 790                 795                 800 


Asp Ile Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu 
                805                 810                 815     


Val Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile Pro Thr Arg Ile 
            820                 825                 830         


Arg Gln Gly Phe Glu Thr Ala Leu Leu 
        835                 840     


<210>  64
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Ala Tyr Glu Arg Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met 
                85                  90                  95      


His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Ser Val 
        115                 120                 125             


Asn Ala Thr Tyr Asn Gly Glu Met Lys Asn Cys Ser Phe Asn Ala Thr 
    130                 135                 140                 


Thr Ala Ile Arg Asp Lys Lys Gln Gln Val Arg Ala Leu Phe Tyr Ser 
145                 150                 155                 160 


Leu Asp Ile Val Pro Leu Glu Gly Asn Asn Ser Ser Tyr Arg Leu Ile 
                165                 170                 175     


Ser Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
            180                 185                 190         


Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Tyr Ala Ile Leu 
        195                 200                 205             


Lys Cys Asn Asp Glu Lys Phe Asn Gly Thr Gly Pro Cys His Asn Val 
    210                 215                 220                 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
225                 230                 235                 240 


Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile Ile Ile Arg Ser 
                245                 250                 255     


Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn Lys 
            260                 265                 270         


Ala Val Glu Ile Val Cys Val Arg Pro Asn Asn Asn Thr Arg Lys Ser 
        275                 280                 285             


Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Asn Asp Ile Ile Gly 
    290                 295                 300                 


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Glu Ser Lys Trp Asn Asp 
305                 310                 315                 320 


Thr Leu Arg Gln Val Gly Ala Lys Leu Ala Glu His Phe Asn Asn Asn 
                325                 330                 335     


Thr Ile Arg Phe Glu Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
            340                 345                 350         


His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
        355                 360                 365             


Leu Phe Asn Gly Thr Tyr Asn His Thr Asp Thr Gly Gly Asn Ser Thr 
    370                 375                 380                 


Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 


Glu Val Gly Arg Cys Ile Tyr Ala Pro Pro Val Glu Gly Asn Ile Ile 
                405                 410                 415     


Cys Ile Ser Asn Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly Gly His 
            420                 425                 430         


Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
        435                 440                 445             


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
    450                 455                 460                 


Leu Gly Val Ala Pro Thr Glu Cys Lys Arg Arg Val Val Glu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly 
                485                 490                 495     


Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
            500                 505                 510         


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
        515                 520                 525             


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln 
    530                 535                 540                 


Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
545                 550                 555                 560 


Arg Val Leu Ser Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
                565                 570                 575     


Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp 
            580                 585                 590         


Asn His Ser Trp Ser Asn Lys Ser Gln Lys Asp Ile Trp Glu Asn Met 
        595                 600                 605             


Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile 
    610                 615                 620                 


Tyr Ser Leu Leu Glu Glu Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys 
625                 630                 635                 640 


Asp Leu Leu Ala Leu Asp 
                645     


<210>  65
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Ala Tyr Glu Arg Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met 
                85                  90                  95      


His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Ser Val 
        115                 120                 125             


Asn Ala Thr Tyr Asn Gly Glu Met Lys Asn Cys Ser Phe Asn Ala Thr 
    130                 135                 140                 


Thr Ala Ile Arg Asp Lys Lys Gln Gln Val Arg Ala Leu Phe Tyr Ser 
145                 150                 155                 160 


Leu Asp Ile Val Pro Leu Glu Gly Asn Asn Ser Ser Tyr Arg Leu Ile 
                165                 170                 175     


Ser Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
            180                 185                 190         


Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Tyr Ala Ile Leu 
        195                 200                 205             


Lys Cys Asn Asp Glu Lys Phe Asn Gly Thr Gly Pro Cys His Asn Val 
    210                 215                 220                 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
225                 230                 235                 240 


Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile Ile Ile Arg Ser 
                245                 250                 255     


Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn Lys 
            260                 265                 270         


Ala Val Glu Ile Val Cys Val Arg Pro Asn Asn Asn Thr Arg Lys Ser 
        275                 280                 285             


Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Asn Asp Ile Ile Gly 
    290                 295                 300                 


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Glu Ser Lys Trp Asn Asp 
305                 310                 315                 320 


Thr Leu Arg Gln Val Gly Ala Lys Leu Ala Glu His Phe Asn Asn Asn 
                325                 330                 335     


Thr Ile Arg Phe Glu Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
            340                 345                 350         


His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
        355                 360                 365             


Leu Phe Asn Gly Thr Tyr Asn His Thr Asp Thr Gly Gly Asn Ser Thr 
    370                 375                 380                 


Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 


Glu Val Gly Arg Cys Ile Tyr Ala Pro Pro Val Glu Gly Asn Ile Ile 
                405                 410                 415     


Cys Ile Ser Asn Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly Gly His 
            420                 425                 430         


Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
        435                 440                 445             


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
    450                 455                 460                 


Leu Gly Val Ala Pro Thr Glu Cys Lys Arg Arg Val Val Glu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly 
                485                 490                 495     


Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
            500                 505                 510         


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
        515                 520                 525             


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln 
    530                 535                 540                 


Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
545                 550                 555                 560 


Arg Val Leu Ser Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
                565                 570                 575     


Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp 
            580                 585                 590         


Asn His Ser Trp Ser Asn Lys Ser Gln Lys Asp Ile Trp Glu Asn Met 
        595                 600                 605             


Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile 
    610                 615                 620                 


Tyr Ser Leu Leu Glu Glu Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys 
625                 630                 635                 640 


Asp Leu Leu Ala Leu Asp Asn Trp Asn Asn Leu Trp Asn Trp Phe Ser 
                645                 650                 655     


Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly 
            660                 665                 670         


Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn 
        675                 680                 685             


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Ile Pro 
    690                 695                 700                 


Ser Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Glu Gln Asp Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ser 
                725                 730                 735     


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
            740                 745                 750         


Leu Arg Asp Phe Leu Leu Val Thr Ala Arg Ala Val Glu Leu Leu Gly 
        755                 760                 765             


Arg Ser Ser Leu Lys Gly Leu Gln Lys Gly Trp Glu Ala Leu Lys Tyr 
    770                 775                 780                 


Leu Gly Asn Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Val 
785                 790                 795                 800 


Ile Ser Leu Ile Asp Ile Ile Ala Ile Ala Val Ala Glu Gly Thr Asp 
                805                 810                 815     


Arg Ile Ile Glu Val Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile 
            820                 825                 830         


Pro Thr Arg Ile Arg Gln Gly Phe Glu Thr Ala Leu Leu 
        835                 840                 845 


<210>  66
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Ala Tyr Glu Arg Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met 
                85                  90                  95      


His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Ser Val 
        115                 120                 125             


Asn Ala Thr Tyr Asn Gly Glu Met Lys Asn Cys Ser Phe Asn Ala Thr 
    130                 135                 140                 


Thr Ala Ile Arg Asp Lys Lys Gln Gln Val Arg Ala Leu Phe Tyr Ser 
145                 150                 155                 160 


Leu Asp Ile Val Pro Leu Glu Gly Asn Asn Ser Ser Tyr Arg Leu Ile 
                165                 170                 175     


Ser Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
            180                 185                 190         


Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Tyr Ala Ile Leu 
        195                 200                 205             


Lys Cys Asn Asp Glu Lys Phe Asn Gly Thr Gly Pro Cys His Asn Val 
    210                 215                 220                 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
225                 230                 235                 240 


Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile Ile Ile Arg Ser 
                245                 250                 255     


Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn Lys 
            260                 265                 270         


Ala Val Glu Ile Val Cys Val Arg Pro Asn Asn Asn Thr Arg Lys Ser 
        275                 280                 285             


Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Asn Asp Ile Ile Gly 
    290                 295                 300                 


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Glu Ser Lys Trp Asn Asp 
305                 310                 315                 320 


Thr Leu Arg Gln Val Gly Ala Lys Leu Ala Glu His Phe Asn Asn Asn 
                325                 330                 335     


Thr Ile Arg Phe Glu Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
            340                 345                 350         


His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
        355                 360                 365             


Leu Phe Asn Gly Thr Tyr Asn His Thr Asp Thr Gly Gly Asn Ser Thr 
    370                 375                 380                 


Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 


Glu Val Gly Arg Cys Ile Tyr Ala Pro Pro Val Glu Gly Asn Ile Ile 
                405                 410                 415     


Cys Ile Ser Asn Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly Gly His 
            420                 425                 430         


Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
        435                 440                 445             


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
    450                 455                 460                 


Leu Gly Val Ala Pro Thr Glu Cys Lys Arg Arg Val Val Glu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly 
                485                 490                 495     


Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
            500                 505                 510         


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
        515                 520                 525             


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln 
    530                 535                 540                 


Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
545                 550                 555                 560 


Arg Val Leu Ser Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
                565                 570                 575     


Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp 
            580                 585                 590         


Asn His Ser Trp Ser Asn Lys Ser Gln Lys Asp Ile Trp Glu Asn Met 
        595                 600                 605             


Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile 
    610                 615                 620                 


Tyr Ser Leu Leu Glu Glu Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys 
625                 630                 635                 640 


Asp Leu Leu Ala Leu Asp Gly Gly Ser Gly Gly Glu Tyr Gly Ser His 
                645                 650                 655     


Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu 
            660                 665                 670         


Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln 
        675                 680                 685             


Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu 
    690                 695                 700                 


Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly 
705                 710                 715                 720 


Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys 
                725                 730                 735     


Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu 
            740                 745                 750         


Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu 
        755                 760                 765             


Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr 
    770                 775                 780                 


Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu 
785                 790                 795                 800 


Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly 
                805                 810                 815     


His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys 
            820                 825                 830         


Thr Val 
        


<210>  67
<211>  1336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Gly Glu Asp Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Pro Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Gly Met Val Glu 
                85                  90                  95      


Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Glu Val 
        115                 120                 125             


Thr Arg Ser Ser Asn Gly Thr Ile Asn Asn Asn Ser Thr Glu Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Val Thr Thr Asp Leu Arg Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Glu Thr 
                165                 170                 175     


Asn Gly Thr Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
            180                 185                 190         


Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Lys Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Ile Ala Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn 
            260                 265                 270         


Ala Lys Ile Ile Ile Val Gln Leu Asn Val Thr Val Glu Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Ile Ser Arg Glu Lys Trp Asn Arg Thr Leu Gln Lys Val 
                325                 330                 335     


Glu Lys Lys Leu Glu Glu Leu Phe Pro Asn Lys Thr Ile His Phe Thr 
            340                 345                 350         


Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Met Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ala Leu Phe Asn Asn Asn 
    370                 375                 380                 


Asn Asp Ser Thr Asn Ser Asn Ile Thr Leu Pro Cys Arg Ile Arg Gln 
385                 390                 395                 400 


Phe Ile Asn Met Trp Gln Glu Val Gly Arg Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Thr Cys Lys Ser Asn Val Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Ile Ile Asn Asp Thr Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Thr Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Ala Val Pro Trp Asn Gly Ser Trp Ser Asn Lys Ser Gln Asp 
        595                 600                 605             


Glu Ile Trp His Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn 
    610                 615                 620                 


Asn Tyr Thr Asn Ile Ile Tyr Gly Leu Leu Glu Val Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Ser Gly Ala 
                645                 650                 655     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            660                 665                 670         


Gly Pro Gly Ser Gly Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr 
        675                 680                 685             


Phe Thr Ala Thr Tyr Ala Gly Asn Leu Trp Val Thr Val Tyr Tyr Gly 
    690                 695                 700                 


Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp 
705                 710                 715                 720 


Ala Lys Ala His Lys Glu Glu Val His Asn Ile Trp Ala Thr His Ala 
                725                 730                 735     


Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Lys Asn Val 
            740                 745                 750         


Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His 
        755                 760                 765             


Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys 
    770                 775                 780                 


Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Val Lys Ile Lys 
785                 790                 795                 800 


Gly Thr Asn Ala Thr Tyr Asn Asn Ala Thr Tyr Asn Asn Asn Asn Thr 
                805                 810                 815     


Ile Ser Asp Met Lys Asn Cys Ser Phe Asn Thr Thr Thr Glu Ile Thr 
            820                 825                 830         


Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val 
        835                 840                 845             


Ala Leu Asp Gly Lys Glu Thr Asn Ser Thr Asn Ser Ser Glu Tyr Arg 
    850                 855                 860                 


Leu Ile Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val 
865                 870                 875                 880 


Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala 
                885                 890                 895     


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn 
            900                 905                 910         


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser 
        915                 920                 925             


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
    930                 935                 940                 


Arg Phe Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val His Leu 
945                 950                 955                 960 


Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg 
                965                 970                 975     


Lys Ser Val Arg Ile Gly Pro Gly Gln Thr Phe Phe Ala Thr Gly Asp 
            980                 985                 990         


Ile Ile Gly Asp Ile Arg Gln Ala  His Cys Asn Ile Ser  Arg Lys Lys 
        995                 1000                 1005             


Trp Asn  Thr Thr Leu Gln Arg  Val Lys Glu Lys Leu  Lys Glu Lys 
    1010                 1015                 1020             


Phe Pro  Asn Lys Thr Ile Gln  Phe Ala Pro Ser Ser  Gly Gly Asp 
    1025                 1030                 1035             


Leu Glu  Ile Thr Thr His Ser  Phe Asn Cys Arg Gly  Glu Phe Phe 
    1040                 1045                 1050             


Tyr Cys  Tyr Thr Ser Asp Leu  Phe Asn Ser Thr Tyr  Met Ser Asn 
    1055                 1060                 1065             


Asn Thr  Gly Gly Ala Asn Ile  Thr Leu Gln Cys Arg  Ile Lys Gln 
    1070                 1075                 1080             


Ile Ile  Arg Met Trp Gln Gly  Val Gly Gln Cys Met  Tyr Ala Pro 
    1085                 1090                 1095             


Pro Ile  Ala Gly Asn Ile Thr  Cys Lys Ser Asn Ile  Thr Gly Leu 
    1100                 1105                 1110             


Leu Leu  Thr Arg Asp Gly Gly  Lys Glu Lys Asn Asp  Thr Glu Thr 
    1115                 1120                 1125             


Phe Arg  Pro Gly Gly Gly Asp  Met Arg Asp Asn Trp  Arg Ser Glu 
    1130                 1135                 1140             


Leu Tyr  Lys Tyr Lys Val Val  Glu Ile Lys Pro Leu  Gly Ile Ala 
    1145                 1150                 1155             


Pro Asp  Lys Cys Lys Arg Arg  Val Val Glu Gly Gly  Ser Gly Gly 
    1160                 1165                 1170             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Ala Val  Gly Ile Gly 
    1175                 1180                 1185             


Ala Val  Phe Leu Gly Phe Leu  Gly Ala Ala Gly Ser  Thr Met Gly 
    1190                 1195                 1200             


Ala Ala  Ser Met Thr Leu Thr  Val Gln Ala Arg Gln  Leu Leu Ser 
    1205                 1210                 1215             


Gly Ile  Val Gln Gln Gln Ser  Asn Leu Leu Arg Ala  Pro Glu Ala 
    1220                 1225                 1230             


Gln Gln  His Met Leu Gln Leu  Thr Val Trp Gly Ile  Lys Gln Leu 
    1235                 1240                 1245             


Gln Thr  Arg Val Leu Ala Ile  Glu Arg Tyr Leu Lys  Asp Gln Gln 
    1250                 1255                 1260             


Leu Leu  Gly Ile Trp Gly Cys  Ser Gly Lys Leu Ile  Cys Cys Thr 
    1265                 1270                 1275             


Ala Val  Pro Trp Asn Ala Ser  Trp Ser Asn Lys Ser  Tyr Glu Glu 
    1280                 1285                 1290             


Ile Trp  Gly Asn Met Thr Trp  Met Gln Trp Asp Arg  Glu Ile Asn 
    1295                 1300                 1305             


Asn Tyr  Thr Asn Thr Ile Tyr  Ser Leu Leu Glu Glu  Ser Gln Asn 
    1310                 1315                 1320             


Gln Gln  Glu Lys Asn Glu Lys  Asp Leu Leu Ala Leu  Asp 
    1325                 1330                 1335     


<210>  68
<211>  1564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Asp Leu 
65                  70                  75                  80  


Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asn Ala 
        115                 120                 125             


Asn Val Thr Ser Glu Asn Ser Thr Ile Met Gly Asp Arg Glu Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu 
                165                 170                 175     


Asn Gln Gly Asn Ser Ser Asn Asn Asn Tyr Ser Glu Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Thr Ala Glu Lys Glu Ile Lys Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Val Lys 
        275                 280                 285             


Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser 
    290                 295                 300                 


Val His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Thr Val Asn Arg Thr Asp Trp Asn 
                325                 330                 335     


Asn Thr Leu Gln Gln Val Ala Lys Gln Leu Gly Lys His Phe Glu Asn 
            340                 345                 350         


Lys Thr Ile Ile Phe Thr Lys Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asn Ser Thr Trp Ser His Asn Asn Ser Thr Leu Leu Gly 
385                 390                 395                 400 


Ser Asn Ser Thr Glu Ser Asn Glu Thr Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Val Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Lys Gly Val Ile Met Cys Val Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Ile Leu Thr Arg Asp Gly Gly Asn Asp Asn Ser Thr Asn Glu Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Arg Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
            580                 585                 590         


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Leu Asp Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Glu Lys Glu Ile Asn Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        675                 680                 685             


Val Glu Glu Asn Pro Gly Pro Gly Ser Gly Met Pro Met Gly Ser Leu 
    690                 695                 700                 


Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu Val Ala Ser Val 
705                 710                 715                 720 


Leu Ala Thr Asp Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
                725                 730                 735     


Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            740                 745                 750         


Tyr Ala Thr Glu Lys His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        755                 760                 765             


Thr Asp Pro Asn Pro Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu 
    770                 775                 780                 


Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Thr Asp Ile 
785                 790                 795                 800 


Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                805                 810                 815     


Leu Cys Val Thr Leu Ser Cys Ser Asn Ala Lys Val Ser Tyr Ser Asn 
            820                 825                 830         


Ala Thr Val Asn Asn Thr Ile Gln Asp Glu Ile Lys Asn Cys Ser Phe 
        835                 840                 845             


Asn Thr Thr Thr Val Leu Arg Asp Lys Arg Gln Lys Val Tyr Ser Leu 
    850                 855                 860                 


Phe Tyr Arg Leu Asp Ile Val Gln Ile Asp Asn Ser Ser Ser Asp Ser 
865                 870                 875                 880 


Ser Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Cys Thr 
                885                 890                 895     


Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys 
            900                 905                 910         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Glu Glu Phe Asn 
        915                 920                 925             


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
    930                 935                 940                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
945                 950                 955                 960 


Lys Arg Glu Val Lys Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
                965                 970                 975     


Asn Ile Ile Val Gln Phe Val Asp Pro Val Glu Ile Asn Cys Thr Arg 
            980                 985                 990         


Pro Asn Asn Asn Thr Arg Lys Ser  Ile His Ile Gly Pro  Gly Gln Ala 
        995                 1000                 1005             


Phe Tyr  Ala Thr Gly Asp Ile  Ile Gly Asp Ile Arg  Gln Ala His 
    1010                 1015                 1020             


Cys Asn  Val Ser Arg Ser Ser  Trp Asn Lys Thr Leu  Gln Gln Val 
    1025                 1030                 1035             


Ala Lys  Gln Leu Gly Thr Tyr  Phe Lys Asn Lys Thr  Ile Val Phe 
    1040                 1045                 1050             


Asn Thr  Ser Ser Gly Gly Asp  Pro Glu Ile Thr Thr  His Ser Phe 
    1055                 1060                 1065             


Asn Cys  Ala Gly Glu Phe Phe  Tyr Cys Asp Thr Ser  Gly Leu Phe 
    1070                 1075                 1080             


Asn Ser  Ser Trp Asn Asp Thr  Thr Trp Lys Glu Ser  Asn Ser Thr 
    1085                 1090                 1095             


Gly Ser  Asn Asp Thr Ile Thr  Leu Leu Cys Arg Ile  Lys Gln Ile 
    1100                 1105                 1110             


Ile Asn  Met Trp Gln Arg Thr  Gly Gln Cys Met Tyr  Ala Pro Pro 
    1115                 1120                 1125             


Ile Pro  Gly Leu Ile Ser Cys  Lys Ser Asn Ile Thr  Gly Ile Ile 
    1130                 1135                 1140             


Leu Thr  Arg Asp Gly Gly Asn  Ser His Arg Thr Glu  Glu Thr Phe 
    1145                 1150                 1155             


Arg Pro  Gly Gly Gly Asp Met  Arg Asp Asn Trp Arg  Ser Glu Leu 
    1160                 1165                 1170             


Tyr Arg  Tyr Lys Val Val Gln  Ile Glu Pro Leu Gly  Val Ala Pro 
    1175                 1180                 1185             


Thr Arg  Cys Arg Arg Arg Val  Val Gln Gly Gly Ser  Gly Gly Gly 
    1190                 1195                 1200             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Ala Val Gly  Ile Gly Ala 
    1205                 1210                 1215             


Val Phe  Leu Gly Phe Leu Gly  Ala Ala Gly Ser Thr  Met Gly Ala 
    1220                 1225                 1230             


Ala Ser  Ile Thr Leu Thr Val  Gln Ala Arg Gln Leu  Leu Ser Gly 
    1235                 1240                 1245             


Ile Val  Gln Gln Gln Ser Asn  Leu Leu Arg Ala Pro  Glu Ala Gln 
    1250                 1255                 1260             


Gln His  Leu Leu Lys Leu Thr  Val Trp Gly Ile Lys  Gln Leu Gln 
    1265                 1270                 1275             


Ala Arg  Val Leu Ala Val Glu  Arg Tyr Leu Arg Asp  Gln Gln Leu 
    1280                 1285                 1290             


Leu Gly  Ile Trp Gly Cys Ser  Gly Lys Leu Ile Cys  Cys Thr Asn 
    1295                 1300                 1305             


Val Pro  Trp Asn Ser Ser Trp  Ser Asn Lys Ser Tyr  Asn Asp Ile 
    1310                 1315                 1320             


Trp Asp  Asn Met Thr Trp Leu  Gln Trp Asp Lys Glu  Ile His Asn 
    1325                 1330                 1335             


Tyr Thr  Gln Leu Ile Tyr Asn  Leu Ile Glu Glu Ser  Gln Asn Gln 
    1340                 1345                 1350             


Gln Glu  Lys Asn Glu Gln Asp  Leu Leu Ala Leu Asp  Lys Trp Ala 
    1355                 1360                 1365             


Asn Leu  Trp Asn Trp Phe Asn  Ile Thr Asn Trp Leu  Trp Tyr Ile 
    1370                 1375                 1380             


Lys Ile  Phe Ile Met Val Val  Gly Gly Leu Ile Gly  Leu Arg Ile 
    1385                 1390                 1395             


Val Phe  Ala Val Leu Ser Ile  Ile Asn Arg Val Arg  Gln Gly Tyr 
    1400                 1405                 1410             


Ser Pro  Leu Ser Phe Gln Thr  His Leu Pro Asn Pro  Arg Asp Leu 
    1415                 1420                 1425             


Asp Arg  Pro Glu Arg Ile Glu  Glu Glu Gly Gly Glu  Gln Gly Arg 
    1430                 1435                 1440             


Asp Arg  Ser Ile Arg Leu Val  Ser Gly Phe Leu Ala  Leu Ala Trp 
    1445                 1450                 1455             


Asp Asp  Leu Arg Ser Leu Cys  Leu Phe Ser Tyr His  Arg Leu Arg 
    1460                 1465                 1470             


Asp Phe  Ile Leu Ile Ala Ala  Arg Thr Val Glu Leu  Leu Gly Gln 
    1475                 1480                 1485             


Ser Ser  Leu Lys Gly Leu Arg  Leu Gly Trp Glu Ser  Leu Lys Tyr 
    1490                 1495                 1500             


Leu Trp  Asn Leu Leu Gly Tyr  Trp Val Arg Glu Leu  Lys Ile Ser 
    1505                 1510                 1515             


Ala Val  Asn Leu Val Asp Thr  Ile Ala Ile Ala Val  Ala Gly Trp 
    1520                 1525                 1530             


Thr Asp  Arg Val Ile Glu Ile  Gly Gln Arg Ile Gly  Arg Ala Ile 
    1535                 1540                 1545             


Arg His  Ile Pro Arg Arg Ile  Arg Gln Gly Leu Glu  Arg Ala Leu 
    1550                 1555                 1560             


Leu 
    


<210>  69
<211>  1390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  69

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Glu Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Glu Cys His Asp Val 
        115                 120                 125             


Asn Val Asn Gly Thr Ala Asn Asn Gly Thr Thr Asn Val Thr Glu Ser 
    130                 135                 140                 


Gly Val Asn Ser Ser Asp Val Thr Ser Asn Asn Val Thr Asn Ser Asn 
145                 150                 155                 160 


Trp Gly Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
                165                 170                 175     


Thr Thr Asn Ile Arg Asp Lys Met Gln Lys Glu Thr Ala Gln Phe Tyr 
            180                 185                 190         


Lys Leu Asp Ile Val Pro Ile Glu Asp Gln Asn Lys Thr Asn Asn Thr 
        195                 200                 205             


Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Cys Thr Gln Ala Cys 
    210                 215                 220                 


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
225                 230                 235                 240 


Gly Phe Ala Ile Leu Lys Cys Asn Asp Arg Asn Phe Asn Gly Thr Gly 
                245                 250                 255     


Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
            260                 265                 270         


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Ala Glu 
        275                 280                 285             


Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile 
    290                 295                 300                 


Ile Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
305                 310                 315                 320 


Asn Thr Ser Lys Arg Ile Ser Ile Gly Pro Gly Arg Ala Phe Arg Ala 
                325                 330                 335     


Thr Lys Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile Ser Arg 
            340                 345                 350         


Ala Thr Trp Asn Ser Thr Leu Lys Lys Ile Val Ala Lys Leu Arg Glu 
        355                 360                 365             


Gln Phe Gly Asn Lys Thr Ile Val Phe Gln Pro Ser Ser Gly Gly Asp 
    370                 375                 380                 


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
385                 390                 395                 400 


Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Ser Thr Glu Glu 
                405                 410                 415     


Ser Asn Ser Thr Glu Glu Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
            420                 425                 430         


Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Met Tyr Ala Pro 
        435                 440                 445             


Pro Ile Glu Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
    450                 455                 460                 


Leu Thr Arg Asp Gly Gly Asn Asn Asn Lys Thr Asn Gly Thr Glu Ile 
465                 470                 475                 480 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                485                 490                 495     


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr 
            500                 505                 510         


Lys Cys Lys Arg Arg Val Val Gln Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Val Gly Ala Met Phe 
    530                 535                 540                 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
545                 550                 555                 560 


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
                565                 570                 575     


Gln Asn Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln 
            580                 585                 590         


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
        595                 600                 605             


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
    610                 615                 620                 


Gly Lys Leu Ile Cys Cys Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
625                 630                 635                 640 


Asn Lys Ser Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp 
                645                 650                 655     


Glu Arg Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu 
            660                 665                 670         


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
        675                 680                 685             


Asp Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    690                 695                 700                 


Val Glu Glu Asn Pro Gly Pro Gly Ser Gly Met Pro Met Gly Ser Leu 
705                 710                 715                 720 


Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu Val Ala Ser Val 
                725                 730                 735     


Leu Ala Ala Asp Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
            740                 745                 750         


Trp Lys Glu Thr Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Arg Ala 
        755                 760                 765             


Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
    770                 775                 780                 


Thr Asp Pro Asn Pro Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn 
785                 790                 795                 800 


Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
                805                 810                 815     


Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Arg Leu Thr Pro 
            820                 825                 830         


Leu Cys Val Thr Leu Asn Cys Ile Asp Tyr Tyr Gly Asn Thr Thr Asn 
        835                 840                 845             


Ser Asn Asn Ser Ser Glu Thr Met Met Glu Lys Gly Glu Ile Lys Asn 
    850                 855                 860                 


Cys Ser Phe Asn Ile Thr Thr Arg Leu Lys Asp Lys Met Gln Lys Glu 
865                 870                 875                 880 


Tyr Ala Leu Phe Tyr Lys Tyr Asp Ile Val Pro Ile Asp Asn Arg Val 
                885                 890                 895     


Gly Asn Asp Thr Ser Asn Ala Thr Ser Tyr Arg Leu Thr Ser Cys Asn 
            900                 905                 910         


Thr Ser Val Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile 
        915                 920                 925             


Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn 
    930                 935                 940                 


Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val 
945                 950                 955                 960 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                965                 970                 975     


Asn Gly Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Phe 
            980                 985                 990         


Thr Asp Asn Ala Lys Thr Ile Ile  Val Gln Leu Asn Glu  Thr Val Glu 
        995                 1000                 1005             


Ile Asn  Cys Thr Arg Pro Asn  Asn Asn Thr Arg Lys  Ser Ile His 
    1010                 1015                 1020             


Met Gly  Pro Gly Lys Val Phe  Tyr Thr Thr Gly Glu  Ile Ile Gly 
    1025                 1030                 1035             


Asp Ile  Arg Gln Ala His Cys  Asn Ile Asn Arg Ala  Lys Trp Asn 
    1040                 1045                 1050             


Asn Thr  Leu Ile Lys Ile Val  Glu Lys Leu Arg Val  Lys Phe Asn 
    1055                 1060                 1065             


Lys Thr  Ile Ser Phe Lys Gln  Ser Ser Gly Gly Asp  Pro Glu Ile 
    1070                 1075                 1080             


Glu Met  His Ser Phe Asn Cys  Gly Gly Glu Phe Phe  Tyr Cys Asn 
    1085                 1090                 1095             


Thr Thr  Gln Leu Phe Asn Ser  Thr Trp Phe Asn Asn  Ala Thr Leu 
    1100                 1105                 1110             


Asn Val  Asn Ser Asn Val Thr  Glu Gly Ser Glu Asn  Ile Thr Leu 
    1115                 1120                 1125             


Pro Cys  Arg Ile Arg Gln Ile  Val Asn Met Trp Gln  Glu Val Gly 
    1130                 1135                 1140             


Lys Cys  Met Tyr Ala Pro Pro  Ile Gln Gly Gln Ile  Arg Cys Ser 
    1145                 1150                 1155             


Ser Asn  Ile Thr Gly Leu Leu  Leu Thr Arg Asp Gly  Gly Gly Ser 
    1160                 1165                 1170             


Asn Ser  Ser Asn Thr Ser Glu  Glu Val Phe Arg Pro  Gly Gly Gly 
    1175                 1180                 1185             


Asn Met  Arg Asp Asn Trp Arg  Ser Glu Leu Tyr Lys  Tyr Lys Val 
    1190                 1195                 1200             


Val Lys  Ile Glu Pro Leu Gly  Ile Ala Pro Thr Lys  Cys Lys Arg 
    1205                 1210                 1215             


Arg Val  Val Gln Gly Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly 
    1220                 1225                 1230             


Gly Ser  Gly Gly Thr Val Gly  Ile Gly Ala Leu Phe  Leu Gly Phe 
    1235                 1240                 1245             


Leu Gly  Ala Ala Gly Ser Thr  Met Gly Ala Ala Ser  Met Thr Leu 
    1250                 1255                 1260             


Thr Val  Gln Ala Arg Gln Leu  Leu Ser Gly Ile Val  Gln Gln Gln 
    1265                 1270                 1275             


Asn Asn  Leu Leu Arg Ala Pro  Gln Ala Gln Gln His  Leu Leu Gln 
    1280                 1285                 1290             


Leu Thr  Val Trp Gly Ile Lys  Gln Leu Gln Ala Arg  Val Leu Ala 
    1295                 1300                 1305             


Val Glu  Arg Tyr Leu Lys Asp  Gln Gln Leu Leu Gly  Ile Trp Gly 
    1310                 1315                 1320             


Cys Ser  Gly Lys Leu Ile Cys  Cys Thr Ala Val Pro  Trp Asn Ala 
    1325                 1330                 1335             


Ser Trp  Ser Asn Lys Ser Leu  Asn Glu Ile Trp Asp  Asn Met Thr 
    1340                 1345                 1350             


Trp Met  Glu Trp Glu Lys Glu  Ile Asp Asn Tyr Thr  Ser Leu Ile 
    1355                 1360                 1365             


Tyr Thr  Leu Ile Glu Glu Ser  Gln Asn Gln Gln Glu  Lys Asn Glu 
    1370                 1375                 1380             


Gln Glu  Leu Leu Glu Leu Asp  
    1385                 1390 


<210>  70
<211>  1702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  70

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Gly Glu Asp Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Pro Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn Gly Met Val Glu 
                85                  90                  95      


Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Glu Val 
        115                 120                 125             


Thr Arg Ser Ser Asn Gly Thr Ile Asn Asn Asn Ser Thr Glu Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Val Thr Thr Asp Leu Arg Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Glu His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Glu Thr 
                165                 170                 175     


Asn Gly Thr Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
            180                 185                 190         


Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Lys Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Ile Ala Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn 
            260                 265                 270         


Ala Lys Ile Ile Ile Val Gln Leu Asn Val Thr Val Glu Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Ile Ser Arg Glu Lys Trp Asn Arg Thr Leu Gln Lys Val 
                325                 330                 335     


Glu Lys Lys Leu Glu Glu Leu Phe Pro Asn Lys Thr Ile His Phe Thr 
            340                 345                 350         


Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Met Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ala Leu Phe Asn Asn Asn 
    370                 375                 380                 


Asn Asp Ser Thr Asn Ser Asn Ile Thr Leu Pro Cys Arg Ile Arg Gln 
385                 390                 395                 400 


Phe Ile Asn Met Trp Gln Glu Val Gly Arg Cys Met Tyr Ala Pro Pro 
                405                 410                 415     


Ile Gln Gly Val Ile Thr Cys Lys Ser Asn Val Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Ile Ile Asn Asp Thr Glu Ile Phe Arg Pro Gly 
        435                 440                 445             


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Thr Cys Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Cys Thr Ala Val Pro Trp Asn Gly Ser Trp Ser Asn Lys Ser Gln Asp 
        595                 600                 605             


Glu Ile Trp His Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn 
    610                 615                 620                 


Asn Tyr Thr Asn Ile Ile Tyr Gly Leu Leu Glu Val Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Gly Ser Gly 
                645                 650                 655     


Gly Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val 
            660                 665                 670         


Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp 
        675                 680                 685             


Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser 
    690                 695                 700                 


Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg 
705                 710                 715                 720 


Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro 
                725                 730                 735     


Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu 
            740                 745                 750         


Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala 
        755                 760                 765             


Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu 
    770                 775                 780                 


Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala 
785                 790                 795                 800 


Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu 
                805                 810                 815     


Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val Gly Ser 
            820                 825                 830         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        835                 840                 845             


Asn Pro Gly Pro Gly Ser Gly Met Lys Ala Lys Leu Leu Val Leu Leu 
    850                 855                 860                 


Cys Thr Phe Thr Ala Thr Tyr Ala Gly Asn Leu Trp Val Thr Val Tyr 
865                 870                 875                 880 


Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala 
                885                 890                 895     


Ser Asp Ala Lys Ala His Lys Glu Glu Val His Asn Ile Trp Ala Thr 
            900                 905                 910         


His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Lys 
        915                 920                 925             


Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln 
    930                 935                 940                 


Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
945                 950                 955                 960 


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Val Lys 
                965                 970                 975     


Ile Lys Gly Thr Asn Ala Thr Tyr Asn Asn Ala Thr Tyr Asn Asn Asn 
            980                 985                 990         


Asn Thr Ile Ser Asp Met Lys Asn  Cys Ser Phe Asn Thr  Thr Thr Glu 
        995                 1000                 1005             


Ile Thr  Asp Lys Lys Lys Lys  Glu Tyr Ala Leu Phe  Tyr Lys Leu 
    1010                 1015                 1020             


Asp Val  Val Ala Leu Asp Gly  Lys Glu Thr Asn Ser  Thr Asn Ser 
    1025                 1030                 1035             


Ser Glu  Tyr Arg Leu Ile Asn  Cys Asn Thr Ser Ala  Cys Thr Gln 
    1040                 1045                 1050             


Ala Cys  Pro Lys Val Ser Phe  Asp Pro Ile Pro Ile  His Tyr Cys 
    1055                 1060                 1065             


Ala Pro  Ala Gly Tyr Ala Ile  Leu Lys Cys Asn Asn  Lys Thr Phe 
    1070                 1075                 1080             


Asn Gly  Thr Gly Pro Cys Asn  Asn Val Ser Thr Val  Gln Cys Thr 
    1085                 1090                 1095             


His Gly  Ile Lys Pro Val Val  Ser Thr Gln Leu Leu  Leu Asn Gly 
    1100                 1105                 1110             


Ser Leu  Ala Glu Glu Glu Val  Val Ile Arg Phe Glu  Asn Leu Thr 
    1115                 1120                 1125             


Asn Asn  Ala Lys Ile Ile Ile  Val His Leu Asn Glu  Ser Val Glu 
    1130                 1135                 1140             


Ile Asn  Cys Thr Arg Pro Ser  Asn Asn Thr Arg Lys  Ser Val Arg 
    1145                 1150                 1155             


Ile Gly  Pro Gly Gln Thr Phe  Phe Ala Thr Gly Asp  Ile Ile Gly 
    1160                 1165                 1170             


Asp Ile  Arg Gln Ala His Cys  Asn Ile Ser Arg Lys  Lys Trp Asn 
    1175                 1180                 1185             


Thr Thr  Leu Gln Arg Val Lys  Glu Lys Leu Lys Glu  Lys Phe Pro 
    1190                 1195                 1200             


Asn Lys  Thr Ile Gln Phe Ala  Pro Ser Ser Gly Gly  Asp Leu Glu 
    1205                 1210                 1215             


Ile Thr  Thr His Ser Phe Asn  Cys Arg Gly Glu Phe  Phe Tyr Cys 
    1220                 1225                 1230             


Tyr Thr  Ser Asp Leu Phe Asn  Ser Thr Tyr Met Ser  Asn Asn Thr 
    1235                 1240                 1245             


Gly Gly  Ala Asn Ile Thr Leu  Gln Cys Arg Ile Lys  Gln Ile Ile 
    1250                 1255                 1260             


Arg Met  Trp Gln Gly Val Gly  Gln Cys Met Tyr Ala  Pro Pro Ile 
    1265                 1270                 1275             


Ala Gly  Asn Ile Thr Cys Lys  Ser Asn Ile Thr Gly  Leu Leu Leu 
    1280                 1285                 1290             


Thr Arg  Asp Gly Gly Lys Glu  Lys Asn Asp Thr Glu  Thr Phe Arg 
    1295                 1300                 1305             


Pro Gly  Gly Gly Asp Met Arg  Asp Asn Trp Arg Ser  Glu Leu Tyr 
    1310                 1315                 1320             


Lys Tyr  Lys Val Val Glu Ile  Lys Pro Leu Gly Ile  Ala Pro Asp 
    1325                 1330                 1335             


Lys Cys  Lys Arg Arg Val Val  Glu Gly Gly Ser Gly  Gly Gly Gly 
    1340                 1345                 1350             


Ser Gly  Gly Gly Gly Ser Gly  Gly Ala Val Gly Ile  Gly Ala Val 
    1355                 1360                 1365             


Phe Leu  Gly Phe Leu Gly Ala  Ala Gly Ser Thr Met  Gly Ala Ala 
    1370                 1375                 1380             


Ser Met  Thr Leu Thr Val Gln  Ala Arg Gln Leu Leu  Ser Gly Ile 
    1385                 1390                 1395             


Val Gln  Gln Gln Ser Asn Leu  Leu Arg Ala Pro Glu  Ala Gln Gln 
    1400                 1405                 1410             


His Met  Leu Gln Leu Thr Val  Trp Gly Ile Lys Gln  Leu Gln Thr 
    1415                 1420                 1425             


Arg Val  Leu Ala Ile Glu Arg  Tyr Leu Lys Asp Gln  Gln Leu Leu 
    1430                 1435                 1440             


Gly Ile  Trp Gly Cys Ser Gly  Lys Leu Ile Cys Cys  Thr Ala Val 
    1445                 1450                 1455             


Pro Trp  Asn Ala Ser Trp Ser  Asn Lys Ser Tyr Glu  Glu Ile Trp 
    1460                 1465                 1470             


Gly Asn  Met Thr Trp Met Gln  Trp Asp Arg Glu Ile  Asn Asn Tyr 
    1475                 1480                 1485             


Thr Asn  Thr Ile Tyr Ser Leu  Leu Glu Glu Ser Gln  Asn Gln Gln 
    1490                 1495                 1500             


Glu Lys  Asn Glu Lys Asp Leu  Leu Ala Leu Asp Gly  Gly Ser Gly 
    1505                 1510                 1515             


Gly Glu  Tyr Gly Ser His Gly  Asn Val Ala Thr Glu  Leu Gln Ala 
    1520                 1525                 1530             


Tyr Ala  Lys Leu His Leu Glu  Arg Ser Tyr Asp Tyr  Leu Leu Ser 
    1535                 1540                 1545             


Ala Ala  Tyr Phe Asn Asn Tyr  Gln Thr Asn Arg Ala  Gly Phe Ser 
    1550                 1555                 1560             


Lys Leu  Phe Lys Lys Leu Ser  Asp Glu Ala Trp Ser  Lys Thr Ile 
    1565                 1570                 1575             


Asp Ile  Ile Lys His Val Thr  Lys Arg Gly Asp Lys  Met Asn Phe 
    1580                 1585                 1590             


Asp Gln  His Ser Thr Met Lys  Thr Glu Arg Lys Asn  Tyr Thr Ala 
    1595                 1600                 1605             


Glu Asn  His Glu Leu Glu Ala  Leu Ala Lys Ala Leu  Asp Thr Gln 
    1610                 1615                 1620             


Lys Glu  Leu Ala Glu Arg Ala  Phe Tyr Ile His Arg  Glu Ala Thr 
    1625                 1630                 1635             


Arg Asn  Ser Gln His Leu His  Asp Pro Glu Ile Ala  Gln Tyr Leu 
    1640                 1645                 1650             


Glu Glu  Glu Phe Ile Glu Asp  His Ala Glu Lys Ile  Arg Thr Leu 
    1655                 1660                 1665             


Ala Gly  His Thr Ser Asp Leu  Lys Lys Phe Ile Thr  Ala Asn Asn 
    1670                 1675                 1680             


Gly His  Asp Leu Ser Leu Ala  Leu Tyr Val Phe Asp  Glu Tyr Leu 
    1685                 1690                 1695             


Gln Lys  Thr Val 
    1700         


<210>  71
<211>  1731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Asp Leu 
65                  70                  75                  80  


Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asn Ala 
        115                 120                 125             


Asn Val Thr Ser Glu Asn Ser Thr Ile Met Gly Asp Arg Glu Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn Glu 
                165                 170                 175     


Asn Gln Gly Asn Ser Ser Asn Asn Asn Tyr Ser Glu Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Cys Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Glu Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Thr Ala Glu Lys Glu Ile Lys Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Val Lys 
        275                 280                 285             


Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser 
    290                 295                 300                 


Val His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Thr Val Asn Arg Thr Asp Trp Asn 
                325                 330                 335     


Asn Thr Leu Gln Gln Val Ala Lys Gln Leu Gly Lys His Phe Glu Asn 
            340                 345                 350         


Lys Thr Ile Ile Phe Thr Lys Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asn Ser Thr Trp Ser His Asn Asn Ser Thr Leu Leu Gly 
385                 390                 395                 400 


Ser Asn Ser Thr Glu Ser Asn Glu Thr Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Val Asn Met Trp Gln Arg Thr Gly Gln Cys Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Lys Gly Val Ile Met Cys Val Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Ile Leu Thr Arg Asp Gly Gly Asn Asp Asn Ser Thr Asn Glu Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Cys Lys Arg Arg Val Val Glu Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Arg Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
            580                 585                 590         


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Cys Thr Ser Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Leu Asp Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Glu Lys Glu Ile Asn Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Gly Gly Ser Gly Gly Arg Ser Cys Arg Asn Ser Met Arg Gln Gln 
        675                 680                 685             


Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala 
    690                 695                 700                 


His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe 
705                 710                 715                 720 


Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu 
                725                 730                 735     


Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu 
            740                 745                 750         


Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala 
        755                 760                 765             


Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg 
    770                 775                 780                 


Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His 
785                 790                 795                 800 


Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly 
                805                 810                 815     


Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp 
            820                 825                 830         


Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly 
        835                 840                 845             


Ile Asp Val Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
    850                 855                 860                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Ser Gly Met Pro Met Gly 
865                 870                 875                 880 


Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu Val Ala 
                885                 890                 895     


Ser Val Leu Ala Thr Asp Asn Leu Trp Val Thr Val Tyr Tyr Gly Val 
            900                 905                 910         


Pro Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala 
        915                 920                 925             


Lys Ala Tyr Ala Thr Glu Lys His Asn Val Trp Ala Thr His Ala Cys 
    930                 935                 940                 


Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu Glu Asn Val Thr 
945                 950                 955                 960 


Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Thr 
                965                 970                 975     


Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu 
            980                 985                 990         


Thr Pro Leu Cys Val Thr Leu Ser  Cys Ser Asn Ala Lys  Val Ser Tyr 
        995                 1000                 1005             


Ser Asn  Ala Thr Val Asn Asn  Thr Ile Gln Asp Glu  Ile Lys Asn 
    1010                 1015                 1020             


Cys Ser  Phe Asn Thr Thr Thr  Val Leu Arg Asp Lys  Arg Gln Lys 
    1025                 1030                 1035             


Val Tyr  Ser Leu Phe Tyr Arg  Leu Asp Ile Val Gln  Ile Asp Asn 
    1040                 1045                 1050             


Ser Ser  Ser Asp Ser Ser Ser  Ser Glu Tyr Arg Leu  Ile Asn Cys 
    1055                 1060                 1065             


Asn Thr  Ser Ala Cys Thr Gln  Ala Cys Pro Lys Val  Thr Phe Glu 
    1070                 1075                 1080             


Pro Ile  Pro Ile His Tyr Cys  Ala Pro Ala Gly Phe  Ala Ile Leu 
    1085                 1090                 1095             


Lys Cys  Lys Asp Glu Glu Phe  Asn Gly Thr Gly Pro  Cys Lys Asn 
    1100                 1105                 1110             


Val Ser  Thr Val Gln Cys Thr  His Gly Ile Lys Pro  Val Val Ser 
    1115                 1120                 1125             


Thr Gln  Leu Leu Leu Asn Gly  Ser Leu Ala Lys Arg  Glu Val Lys 
    1130                 1135                 1140             


Ile Arg  Ser Glu Asn Ile Thr  Asn Asn Ala Lys Asn  Ile Ile Val 
    1145                 1150                 1155             


Gln Phe  Val Asp Pro Val Glu  Ile Asn Cys Thr Arg  Pro Asn Asn 
    1160                 1165                 1170             


Asn Thr  Arg Lys Ser Ile His  Ile Gly Pro Gly Gln  Ala Phe Tyr 
    1175                 1180                 1185             


Ala Thr  Gly Asp Ile Ile Gly  Asp Ile Arg Gln Ala  His Cys Asn 
    1190                 1195                 1200             


Val Ser  Arg Ser Ser Trp Asn  Lys Thr Leu Gln Gln  Val Ala Lys 
    1205                 1210                 1215             


Gln Leu  Gly Thr Tyr Phe Lys  Asn Lys Thr Ile Val  Phe Asn Thr 
    1220                 1225                 1230             


Ser Ser  Gly Gly Asp Pro Glu  Ile Thr Thr His Ser  Phe Asn Cys 
    1235                 1240                 1245             


Ala Gly  Glu Phe Phe Tyr Cys  Asp Thr Ser Gly Leu  Phe Asn Ser 
    1250                 1255                 1260             


Ser Trp  Asn Asp Thr Thr Trp  Lys Glu Ser Asn Ser  Thr Gly Ser 
    1265                 1270                 1275             


Asn Asp  Thr Ile Thr Leu Leu  Cys Arg Ile Lys Gln  Ile Ile Asn 
    1280                 1285                 1290             


Met Trp  Gln Arg Thr Gly Gln  Cys Met Tyr Ala Pro  Pro Ile Pro 
    1295                 1300                 1305             


Gly Leu  Ile Ser Cys Lys Ser  Asn Ile Thr Gly Ile  Ile Leu Thr 
    1310                 1315                 1320             


Arg Asp  Gly Gly Asn Ser His  Arg Thr Glu Glu Thr  Phe Arg Pro 
    1325                 1330                 1335             


Gly Gly  Gly Asp Met Arg Asp  Asn Trp Arg Ser Glu  Leu Tyr Arg 
    1340                 1345                 1350             


Tyr Lys  Val Val Gln Ile Glu  Pro Leu Gly Val Ala  Pro Thr Arg 
    1355                 1360                 1365             


Cys Arg  Arg Arg Val Val Gln  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1370                 1375                 1380             


Gly Gly  Gly Gly Ser Gly Gly  Ala Val Gly Ile Gly  Ala Val Phe 
    1385                 1390                 1395             


Leu Gly  Phe Leu Gly Ala Ala  Gly Ser Thr Met Gly  Ala Ala Ser 
    1400                 1405                 1410             


Ile Thr  Leu Thr Val Gln Ala  Arg Gln Leu Leu Ser  Gly Ile Val 
    1415                 1420                 1425             


Gln Gln  Gln Ser Asn Leu Leu  Arg Ala Pro Glu Ala  Gln Gln His 
    1430                 1435                 1440             


Leu Leu  Lys Leu Thr Val Trp  Gly Ile Lys Gln Leu  Gln Ala Arg 
    1445                 1450                 1455             


Val Leu  Ala Val Glu Arg Tyr  Leu Arg Asp Gln Gln  Leu Leu Gly 
    1460                 1465                 1470             


Ile Trp  Gly Cys Ser Gly Lys  Leu Ile Cys Cys Thr  Asn Val Pro 
    1475                 1480                 1485             


Trp Asn  Ser Ser Trp Ser Asn  Lys Ser Tyr Asn Asp  Ile Trp Asp 
    1490                 1495                 1500             


Asn Met  Thr Trp Leu Gln Trp  Asp Lys Glu Ile His  Asn Tyr Thr 
    1505                 1510                 1515             


Gln Leu  Ile Tyr Asn Leu Ile  Glu Glu Ser Gln Asn  Gln Gln Glu 
    1520                 1525                 1530             


Lys Asn  Glu Gln Asp Leu Leu  Ala Leu Asp Gly Gly  Ser Gly Gly 
    1535                 1540                 1545             


Glu Tyr  Gly Ser His Gly Asn  Val Ala Thr Glu Leu  Gln Ala Tyr 
    1550                 1555                 1560             


Ala Lys  Leu His Leu Glu Arg  Ser Tyr Asp Tyr Leu  Leu Ser Ala 
    1565                 1570                 1575             


Ala Tyr  Phe Asn Asn Tyr Gln  Thr Asn Arg Ala Gly  Phe Ser Lys 
    1580                 1585                 1590             


Leu Phe  Lys Lys Leu Ser Asp  Glu Ala Trp Ser Lys  Thr Ile Asp 
    1595                 1600                 1605             


Ile Ile  Lys His Val Thr Lys  Arg Gly Asp Lys Met  Asn Phe Asp 
    1610                 1615                 1620             


Gln His  Ser Thr Met Lys Thr  Glu Arg Lys Asn Tyr  Thr Ala Glu 
    1625                 1630                 1635             


Asn His  Glu Leu Glu Ala Leu  Ala Lys Ala Leu Asp  Thr Gln Lys 
    1640                 1645                 1650             


Glu Leu  Ala Glu Arg Ala Phe  Tyr Ile His Arg Glu  Ala Thr Arg 
    1655                 1660                 1665             


Asn Ser  Gln His Leu His Asp  Pro Glu Ile Ala Gln  Tyr Leu Glu 
    1670                 1675                 1680             


Glu Glu  Phe Ile Glu Asp His  Ala Glu Lys Ile Arg  Thr Leu Ala 
    1685                 1690                 1695             


Gly His  Thr Ser Asp Leu Lys  Lys Phe Ile Thr Ala  Asn Asn Gly 
    1700                 1705                 1710             


His Asp  Leu Ser Leu Ala Leu  Tyr Val Phe Asp Glu  Tyr Leu Gln 
    1715                 1720                 1725             


Lys Thr  Val 
    1730     


