                         б

<110>  ż򣨱Ƽ޹˾
 
<120>  һƺۺķҩ

<130>  FE00359PCT

<150>  PCT/2020/084925
<151>  2020-04-15

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  hIDUA-F1

<400>  1
cgcttccagg tcaacaacac                                                   20


<210>  2
<211>  19
<212>  DNA
<213>  ˹

<220>
<223>  hIDUA-R1

<400>  2
ctcgcgtaga tcagcaccg                                                    19


<210>  3
<211>  111
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  3
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca uccagcagcg ccagcagccc cauggccgug agcaccggcu u               111


<210>  4
<211>  111
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  4
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggggc gggggggggc cgucgccgcg uggggucguu g               111


<210>  5
<211>  111
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  5
uaccgcuaca gccacgcuga uuucagcuau accugcccgg uauaaaggga cguucacacc       60

gcgauguucu cugcugggga auugcgcgau auucaggauu aaaagaagug c               111


<210>  6
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  6
uaauccugaa uaucgcgcaa uuccccagca gagaacaucg cggugugaac gucccuuuau       60

accgggcagg uauagcugaa aucagcgugg c                                      91


<210>  7
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  7
uuucagcuau accugcccgg uauaaaggga cguucacacc gcgauguucu cugcugggga       60

auugcgcgau a                                                            71


<210>  8
<211>  51
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  8
uuccccagca gagaacaucg cggugugaac gucccuuuau accgggcagg u                51


<210>  9
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  9
gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca       60

ucugcggggc gggggggggc cgucgccgcg u                                      91


<210>  10
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  10
uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca ucugcggggc       60

gggggggggc c                                                            71


<210>  11
<211>  51
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  11
ggucccggcc ugcgacacuu cggcccagag cugcuccuca ucugcggggc g                51


<210>  12
<211>  101
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  12
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggggc gggggggggc cgucgccgcg u                          101


<210>  13
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  13
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggggc gggggggggc c                                      91


<210>  14
<211>  81
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  14
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggggc g                                                 81


<210>  15
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  15
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca u                                                            71


<210>  16
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  16
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

c                                                                       61


<210>  17
<211>  101
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  17
gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca       60

ucugcggggc gggggggggc cgucgccgcg uggggucguu g                          101


<210>  18
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  18
uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca ucugcggggc       60

gggggggggc cgucgccgcg uggggucguu g                                      91


<210>  19
<211>  81
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  19
ggucccggcc ugcgacacuu cggcccagag cugcuccuca ucugcggggc gggggggggc       60

cgucgccgcg uggggucguu g                                                 81


<210>  20
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  20
ugcgacacuu cggcccagag cugcuccuca ucugcggggc gggggggggc cgucgccgcg       60

uggggucguu g                                                            71


<210>  21
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  21
cggcccagag cugcuccuca ucugcggggc gggggggggc cgucgccgcg uggggucguu       60

g                                                                       61


<210>  22
<211>  80
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  22
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggggc                                                   80


<210>  23
<211>  79
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  23
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcgggg                                                    79


<210>  24
<211>  78
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  24
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggg                                                     78


<210>  25
<211>  77
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  25
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcgg                                                      77


<210>  26
<211>  76
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  26
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcg                                                       76


<210>  27
<211>  75
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  27
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugc                                                        75


<210>  28
<211>  74
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  28
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucug                                                         74


<210>  29
<211>  73
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  29
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucu                                                          73


<210>  30
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  30
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca uc                                                           72


<210>  31
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  31
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca                                                              70


<210>  32
<211>  69
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  32
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuc                                                               69


<210>  33
<211>  68
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  33
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccu                                                                68


<210>  34
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  34
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcucc                                                                 67


<210>  35
<211>  66
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  35
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuc                                                                  66


<210>  36
<211>  65
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  36
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcu                                                                   65


<210>  37
<211>  64
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  37
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugc                                                                    64


<210>  38
<211>  63
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  38
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cug                                                                     63


<210>  39
<211>  62
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  39
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cu                                                                      62


<210>  40
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  40
uaccgcuaca gccacgcuga uuucagcuau accugcccgg uauaaaggga cguucacacc       60

gcgauguucu                                                              70


<210>  41
<211>  66
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  41
uaccgcuaca gccacgcuga uuucagcuau accugcccgg uauaaaggga cguucacacc       60

gcgaug                                                                  66


<210>  42
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  42
ccaccgugug guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu       60

ccucaucugc g                                                            71


<210>  43
<211>  66
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  43
gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca       60

ucugcg                                                                  66


<210>  44
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  44
guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu ccucaucugc       60

g                                                                       61


<210>  45
<211>  56
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  45
uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca ucugcg           56


<210>  46
<211>  66
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  46
ccaccgugug guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu       60

ccucau                                                                  66


<210>  47
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  47
gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca       60

u                                                                       61


<210>  48
<211>  56
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  48
guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu ccucau           56


<210>  49
<211>  51
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  49
uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca u                51


<210>  50
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  50
acgcccaccg ugugguugcu guccaggacg gucccggccu gcgacacuuc ggcccagagc       60

ugcuccu                                                                 67


<210>  51
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  51
cgcccaccgu gugguugcug uccaggacgg ucccggccug cgacacuucg gcccagagcu       60

gcuccuc                                                                 67


<210>  52
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  52
gcccaccgug ugguugcugu ccaggacggu cccggccugc gacacuucgg cccagagcug       60

cuccuca                                                                 67


<210>  53
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  53
cccaccgugu gguugcuguc caggacgguc ccggccugcg acacuucggc ccagagcugc       60

uccucau                                                                 67


<210>  54
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  54
ccaccgugug guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu       60

ccucauc                                                                 67


<210>  55
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  55
caccgugugg uugcugucca ggacgguccc ggccugcgac acuucggccc agagcugcuc       60

cucaucu                                                                 67


<210>  56
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  56
accguguggu ugcuguccag gacggucccg gccugcgaca cuucggccca gagcugcucc       60

ucaucug                                                                 67


<210>  57
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  57
ccgugugguu gcuguccagg acggucccgg ccugcgacac uucggcccag agcugcuccu       60

caucugc                                                                 67


<210>  58
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  58
cgugugguug cuguccagga cggucccggc cugcgacacu ucggcccaga gcugcuccuc       60

aucugcg                                                                 67


<210>  59
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  59
gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag cugcuccuca       60

ucugcgg                                                                 67


<210>  60
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  60
ugugguugcu guccaggacg gucccggccu gcgacacuuc ggcccagagc ugcuccucau       60

cugcggg                                                                 67


<210>  61
<211>  67
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  61
gugguugcug uccaggacgg ucccggccug cgacacuucg gcccagagcu gcuccucauc       60

ugcgggg                                                                 67


<210>  62
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  62
acgcccaccg ugugguugcu guccaggacg gucccggccu gcgacacuuc ggcccagagc       60

ugcuccucau                                                              70


<210>  63
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  63
cgcccaccgu gugguugcug uccaggacgg ucccggccug cgacacuucg gcccagagcu       60

gcuccucauc                                                              70


<210>  64
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  64
gcccaccgug ugguugcugu ccaggacggu cccggccugc gacacuucgg cccagagcug       60

cuccucaucu                                                              70


<210>  65
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  65
cccaccgugu gguugcuguc caggacgguc ccggccugcg acacuucggc ccagagcugc       60

uccucaucug                                                              70


<210>  66
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  66
ccaccgugug guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu       60

ccucaucugc                                                              70


<210>  67
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  67
caccgugugg uugcugucca ggacgguccc ggccugcgac acuucggccc agagcugcuc       60

cucaucugcg                                                              70


<210>  68
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  68
accguguggu ugcuguccag gacggucccg gccugcgaca cuucggccca gagcugcucc       60

ucaucugcgg                                                              70


<210>  69
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  69
ccgugugguu gcuguccagg acggucccgg ccugcgacac uucggcccag agcugcuccu       60

caucugcggg                                                              70


<210>  70
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  70
cgugugguug cuguccagga cggucccggc cugcgacacu ucggcccaga gcugcuccuc       60

aucugcgggg                                                              70


<210>  71
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  71
acgcccaccg ugugguugcu guccaggacg gucccggccu gcgacacuuc ggcccagagc       60

ugcuccucau cu                                                           72


<210>  72
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  72
cgcccaccgu gugguugcug uccaggacgg ucccggccug cgacacuucg gcccagagcu       60

gcuccucauc ug                                                           72


<210>  73
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  73
gcccaccgug ugguugcugu ccaggacggu cccggccugc gacacuucgg cccagagcug       60

cuccucaucu gc                                                           72


<210>  74
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  74
cccaccgugu gguugcuguc caggacgguc ccggccugcg acacuucggc ccagagcugc       60

uccucaucug cg                                                           72


<210>  75
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  75
ccaccgugug guugcugucc aggacggucc cggccugcga cacuucggcc cagagcugcu       60

ccucaucugc gg                                                           72


<210>  76
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  76
caccgugugg uugcugucca ggacgguccc ggccugcgac acuucggccc agagcugcuc       60

cucaucugcg gg                                                           72


<210>  77
<211>  72
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  77
accguguggu ugcuguccag gacggucccg gccugcgaca cuucggccca gagcugcucc       60

ucaucugcgg gg                                                           72


<210>  78
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  hIDUA-62F

<400>  78
ccttcctgag ctaccacccg                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  hIDUA-62R

<400>  79
ccagggctcg aactcggtag                                                   20


<210>  80
<211>  70
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  80
caccgugugg uugcugucca ggacgguccc ggccugcgac acuucggccc agagccgcuc       60

cucaucugcg                                                              70


<210>  81
<211>  50
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  81
cuguccagga cggucccggc cugcgacacu ucggcccaga gcugcuccuc                  50


<210>  82
<211>  34
<212>  DNA
<213>  ˹

<220>
<223>  arRNA

<400>  82
gatgaggagc agctctgggc cgaagtgtcg cagg                                   34


<210>  83
<211>  34
<212>  DNA
<213>  ˹

<220>
<223>  arRNA

<400>  83
gatgaggagc agctctaggc cgaagtgtcg cagg                                   34


