                         SEQUENCE LISTING

<110>  BIORCHESTRA CO., LTD.
 
<120>  SETD7 EPIGENETIC MODULATORS

<130>  4366.004PC01

<150>  US 63/010,026
<151>  2020-04-14

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is  Serine (S), Threonine (T), a phosphomimetic amino acid 
       such as aspartic acid (D) or glutamic acid (E), or an analog 
       thereof

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is  Serine (S), Threonine (T), a phosphomimetic amino acid 
       such as aspartic acid (D) or glutamic acid (E), or an analog 
       thereof

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is  Serine (S), Threonine (T), a phosphomimetic amino acid 
       such as aspartic acid (D) or glutamic acid (E), or an analog 
       thereof

<400>  1

Xaa Val Ala Tyr Gly Tyr Asp His Xaa Pro Pro Gly Lys Xaa 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild Type

<400>  2

Thr Val Ala Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Ser 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  comprises N- and/or C-terminal modification

<400>  3

Thr Val Ala Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Ser 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, T>S substituted

<400>  4

Thr Val Ala Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Thr 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, 1st S of WT substituted

<400>  5

Ser Val Ala Tyr Gly Tyr Asp His Thr Pro Pro Gly Lys Ser 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, 2nd S of WT substituted

<400>  6

Thr Val Ala Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Thr 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, T and 1st S of WT substituted

<400>  7

Ser Val Ala Tyr Gly Tyr Asp His Thr Pro Pro Gly Lys Ser 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, T and 2nd S of WT substituted

<400>  8

Ser Val Ala Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Thr 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, 1st S and 2nd S of WT substituted

<400>  9

Thr Val Ala Tyr Gly Tyr Asp His Thr Pro Pro Gly Lys Thr 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated peptide, all S and T of of WT substituted

<400>  10

Ser Val Ala Tyr Gly Tyr Asp His Thr Pro Pro Gly Lys Thr 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids, 
       all E

<400>  11

Glu Val Ala Tyr Gly Tyr Asp His Glu Pro Pro Gly Lys Glu 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids, 
       all D

<400>  12

Asp Val Ala Tyr Gly Tyr Asp His Asp Pro Pro Gly Lys Asp 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids

<400>  13

Glu Val Ala Tyr Gly Tyr Asp His Asp Pro Pro Gly Lys Glu 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids

<400>  14

Glu Val Ala Tyr Gly Tyr Asp His Glu Pro Pro Gly Lys Asp 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids

<400>  15

Glu Val Ala Tyr Gly Tyr Asp His Asp Pro Pro Gly Lys Asp 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids

<400>  16

Asp Val Ala Tyr Gly Tyr Asp His Glu Pro Pro Gly Lys Glu 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids

<400>  17

Asp Val Ala Tyr Gly Tyr Asp His Asp Pro Pro Gly Lys Glu 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-phosphorylated peptide with phosphomimetic D/E amino acids

<400>  18

Asp Val Ala Tyr Gly Tyr Asp His Glu Pro Pro Gly Lys Asp 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is serine (S), threonine (T), aspartic acid (D), glutamic 
       acid (E), 2-amino-4-phosphobutyric acid (L-AP4, L-APB), or 
       thiophosphoserine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is  tyrosine (Y) or and 4-phosphomethyl-L-phenylalanine (Pmp)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is  tyrosine (Y) or and 4-phosphomethyl-L-phenylalanine (Pmp)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is serine (S), threonine (T), aspartic acid (D), glutamic 
       acid (E), 2-amino-4-phosphobutyric acid (L-AP4, L-APB), or 
       thiophosphoserine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is serine (S), threonine (T), aspartic acid (D), glutamic 
       acid (E), 2-amino-4-phosphobutyric acid (L-AP4, L-APB), or 
       thiophosphoserine

<400>  19

Xaa Val Ala Xaa Gly Xaa Asp His Xaa Pro Pro Gly Lys Xaa 
1               5                   10                  


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  can be appended to the N-terminus of SEQ ID NO:19

<400>  20

Asp Glu Glu Leu 
1               


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  can be appended to the N-terminus of SEQ ID NO:19

<400>  21

Ala Asp Glu Glu Leu 
1               5   


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  can be appended to the C-terminus of SEQ ID NO:19

<400>  22

Gly Pro Glu Ala 
1               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  can be appended to the N-terminus of SEQ ID NO:19

<400>  23

Gly Pro Glu Ala Pro 
1               5   


<210>  24
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide EEE

<400>  24

Ala Asp Glu Glu Leu Glu Val Ala Tyr Gly Tyr Asp His Glu Pro Pro 
1               5                   10                  15      


Gly Lys Glu Gly Pro Glu Ala Pro 
            20                  


<210>  25
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide EDE

<400>  25

Ala Asp Glu Glu Leu Glu Val Ala Tyr Gly Tyr Asp His Asp Pro Pro 
1               5                   10                  15      


Gly Lys Glu Gly Pro Glu Ala Pro 
            20                  


<210>  26
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide EED

<400>  26

Ala Asp Glu Glu Leu Glu Val Ala Tyr Gly Tyr Asp His Glu Pro Pro 
1               5                   10                  15      


Gly Lys Asp Gly Pro Glu Ala Pro 
            20                  


<210>  27
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide EDD

<400>  27

Ala Asp Glu Glu Leu Glu Val Ala Tyr Gly Tyr Asp His Asp Pro Pro 
1               5                   10                  15      


Gly Lys Asp Gly Pro Glu Ala Pro 
            20                  


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide DEE

<400>  28

Ala Asp Glu Glu Leu Asp Val Ala Tyr Gly Tyr Asp His Glu Pro Pro 
1               5                   10                  15      


Gly Lys Glu Gly Pro Glu Ala Pro 
            20                  


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide DED

<400>  29

Ala Asp Glu Glu Leu Asp Val Ala Tyr Gly Tyr Asp His Glu Pro Pro 
1               5                   10                  15      


Gly Lys Asp Gly Pro Glu Ala Pro 
            20                  


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide DDE

<400>  30

Ala Asp Glu Glu Leu Asp Val Ala Tyr Gly Tyr Asp His Asp Pro Pro 
1               5                   10                  15      


Gly Lys Glu Gly Pro Glu Ala Pro 
            20                  


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide DDD

<400>  31

Ala Asp Glu Glu Leu Asp Val Ala Tyr Gly Tyr Asp His Asp Pro Pro 
1               5                   10                  15      


Gly Lys Asp Gly Pro Glu Ala Pro 
            20                  


<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended phosphomimetic peptide

<400>  32

Ala Asp Glu Glu Leu Thr Val Ala Tyr Gly Tyr Asp His Ser Pro Pro 
1               5                   10                  15      


Gly Lys Ser Gly Pro Glu Ala Pro 
            20                  


<210>  33
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  N is a purine (e.g., A or G)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  N is a purine (e.g., A or G)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  N is a purine (e.g., A or G)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  N is a purine (e.g., A or G)

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  N is a purine (e.g., A or G)

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  N is a purine (e.g., A or G)

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  N is a purine (e.g., A or G)

<400>  33
gcngangarg arnungargu ngcnuanggn uangancang anccnccngg naarganggn       60

ccngargcnc cnurr                                                        75


<210>  34
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  N is a purine (A or G)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  N  is a purine (A or G)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  N is a pyrimidine (e.g., C, T, or U)

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  N  is a weak bonding nucleotide (e.g., A, T or U)

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  N  is a strong bonding nucleotide (e.g., G or C)

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  N  is a purine (A or G)

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  N  is a weak bonding nucleotide (e.g., A, T or U)

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  N  is a strong bonding nucleotide (e.g., G or C)

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  N is a purine (A or G)

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  N is any nucleotide (e.g., A, G, T, U, or C)

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  N is a purine (A or G)

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  N is a purine (A or G)

<400>  34
gcngangang annunacngu ngcnuanggn uangancann nnccnccngg naannnnggn       60

ccngangcnc cnunn                                                        75


<210>  35
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (332)..(332)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (340)..(340)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (345)..(345)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Met Asp Ser Asp Asp Glu Met Val Glu Glu Ala Val Glu Gly His Leu 
1               5                   10                  15      


Asp Asp Asp Gly Leu Pro His Gly Phe Cys Thr Val Thr Tyr Ser Ser 
            20                  25                  30          


Thr Asp Arg Phe Glu Gly Asn Phe Val His Gly Glu Lys Asn Gly Arg 
        35                  40                  45              


Gly Lys Phe Phe Phe Phe Asp Gly Ser Thr Leu Glu Gly Tyr Tyr Val 
    50                  55                  60                  


Asp Asp Ala Leu Gln Gly Gln Gly Val Tyr Thr Tyr Glu Asp Gly Gly 
65                  70                  75                  80  


Val Leu Gln Gly Thr Tyr Val Asp Gly Glu Leu Asn Gly Pro Ala Gln 
                85                  90                  95      


Glu Tyr Asp Thr Asp Gly Arg Leu Ile Phe Lys Gly Gln Tyr Lys Asp 
            100                 105                 110         


Asn Ile Arg His Gly Val Cys Trp Ile Tyr Tyr Pro Asp Gly Gly Ser 
        115                 120                 125             


Leu Val Gly Glu Val Asn Glu Asp Gly Glu Met Thr Gly Glu Lys Ile 
    130                 135                 140                 


Ala Tyr Val Tyr Pro Asp Glu Arg Thr Ala Leu Tyr Gly Lys Phe Ile 
145                 150                 155                 160 


Asp Gly Glu Met Ile Glu Gly Lys Leu Ala Thr Leu Met Ser Thr Glu 
                165                 170                 175     


Glu Gly Arg Pro His Phe Glu Leu Met Pro Gly Asn Ser Val Tyr His 
            180                 185                 190         


Phe Asp Lys Ser Thr Ser Ser Cys Ile Ser Thr Asn Ala Leu Leu Pro 
        195                 200                 205             


Asp Pro Tyr Glu Ser Glu Arg Val Tyr Val Ala Glu Ser Leu Ile Ser 
    210                 215                 220                 


Ser Ala Gly Glu Gly Leu Phe Ser Lys Val Ala Val Gly Pro Asn Thr 
225                 230                 235                 240 


Val Met Ser Phe Tyr Asn Gly Val Arg Ile Thr His Gln Glu Val Asp 
                245                 250                 255     


Ser Arg Asp Trp Ala Leu Asn Gly Asn Thr Leu Ser Leu Asp Glu Glu 
            260                 265                 270         


Thr Val Ile Asp Val Pro Glu Pro Tyr Asn His Val Ser Lys Tyr Cys 
        275                 280                 285             


Ala Ser Leu Gly His Lys Ala Asn Ala Ser Phe Thr Pro Asn Cys Ile 
    290                 295                 300                 


Tyr Asp Met Phe Val His Pro Arg Phe Gly Pro Ile Lys Cys Ile Arg 
305                 310                 315                 320 


Thr Leu Arg Ala Val Glu Ala Asp Glu Glu Leu Xaa Val Ala Tyr Gly 
                325                 330                 335     


Tyr Asp His Xaa Pro Pro Gly Lys Xaa Gly Pro Glu Ala Pro Glu Trp 
            340                 345                 350         


Tyr Gln Val Glu Leu Lys Ala Phe Gln Ala Thr Gln Gln Lys 
        355                 360                 365     


<210>  36
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Ala Gly Gly Ala Tyr Trp Ser Asn Gly Ala Tyr Gly Ala Tyr Gly Ala 
1               5                   10                  15      


Arg Ala Gly Gly Asn Gly Ala Arg Gly Ala Arg Gly Cys Asn Gly Asn 
            20                  25                  30          


Gly Ala Arg Gly Gly Asn Cys Ala Tyr Tyr Asn Gly Ala Tyr Gly Ala 
        35                  40                  45              


Tyr Gly Ala Tyr Gly Gly Asn Tyr Asn Cys Cys Asn Cys Ala Tyr Gly 
    50                  55                  60                  


Gly Asn Tyr Gly Tyr Ala Cys Asn Gly Asn Ala Cys Asn Ala Tyr Trp 
65                  70                  75                  80  


Ser Asn Trp Ser Asn Ala Cys Asn Gly Ala Tyr Met Gly Asn Tyr Gly 
                85                  90                  95      


Ala Arg Gly Gly Asn Ala Ala Tyr Tyr Gly Asn Cys Ala Tyr Gly Gly 
            100                 105                 110         


Asn Gly Ala Arg Ala Ala Arg Ala Ala Tyr Gly Gly Asn Met Gly Asn 
        115                 120                 125             


Gly Gly Asn Ala Ala Arg Tyr Tyr Tyr Tyr Gly Ala Tyr Gly Gly Asn 
    130                 135                 140                 


Trp Ser Asn Ala Cys Asn Tyr Asn Gly Ala Arg Gly Gly Asn Ala Tyr 
145                 150                 155                 160 


Ala Tyr Gly Asn Gly Ala Tyr Gly Ala Tyr Gly Cys Asn Tyr Asn Cys 
                165                 170                 175     


Ala Arg Gly Gly Asn Cys Ala Arg Gly Gly Asn Gly Asn Ala Tyr Ala 
            180                 185                 190         


Cys Asn Ala Tyr Gly Ala Arg Gly Ala Tyr Gly Gly Asn Gly Gly Asn 
        195                 200                 205             


Gly Asn Tyr Asn Cys Ala Arg Gly Gly Asn Ala Cys Asn Ala Tyr Gly 
    210                 215                 220                 


Asn Gly Ala Tyr Gly Gly Asn Gly Ala Arg Tyr Asn Ala Ala Tyr Gly 
225                 230                 235                 240 


Gly Asn Cys Cys Asn Gly Cys Asn Cys Ala Arg Gly Ala Arg Ala Tyr 
                245                 250                 255     


Gly Ala Tyr Ala Cys Asn Gly Ala Tyr Gly Gly Asn Met Gly Asn Tyr 
            260                 265                 270         


Asn Ala His Tyr Ala Ala Arg Gly Gly Asn Cys Ala Arg Ala Tyr Ala 
        275                 280                 285             


Ala Arg Gly Ala Tyr Ala Ala Tyr Ala His Met Gly Asn Cys Ala Tyr 
    290                 295                 300                 


Gly Gly Asn Gly Asn Gly Tyr Gly Gly Ala His Ala Tyr Ala Tyr Cys 
305                 310                 315                 320 


Cys Asn Gly Ala Tyr Gly Gly Asn Gly Gly Asn Trp Ser Asn Tyr Asn 
                325                 330                 335     


Gly Asn Gly Gly Asn Gly Ala Arg Gly Asn Ala Ala Tyr Gly Ala Arg 
            340                 345                 350         


Gly Ala Tyr Gly Gly Asn Gly Ala Arg Ala Gly Ala Cys Asn Gly Gly 
        355                 360                 365             


Asn Gly Ala Arg Ala Ala Arg Ala His Gly Cys Asn Ala Tyr Gly Asn 
    370                 375                 380                 


Ala Tyr Cys Cys Asn Gly Ala Tyr Gly Ala Arg Met Gly Asn Ala Cys 
385                 390                 395                 400 


Asn Gly Cys Asn Tyr Asn Ala Tyr Gly Gly Asn Ala Ala Arg Tyr Ala 
                405                 410                 415     


His Gly Ala Tyr Gly Gly Asn Gly Ala Arg Ala Gly Ala His Gly Ala 
            420                 425                 430         


Arg Gly Gly Asn Ala Ala Arg Tyr Asn Gly Cys Asn Ala Cys Asn Tyr 
        435                 440                 445             


Asn Ala Gly Trp Ser Asn Ala Cys Asn Gly Ala Arg Gly Ala Arg Gly 
    450                 455                 460                 


Gly Asn Met Gly Asn Cys Cys Asn Cys Ala Tyr Tyr Gly Ala Arg Tyr 
465                 470                 475                 480 


Asn Ala Gly Cys Cys Asn Gly Gly Asn Ala Ala Tyr Trp Ser Asn Gly 
                485                 490                 495     


Asn Ala Tyr Cys Ala Tyr Tyr Gly Ala Tyr Ala Ala Arg Trp Ser Asn 
            500                 505                 510         


Ala Cys Asn Trp Ser Asn Trp Ser Asn Gly Tyr Ala His Trp Ser Asn 
        515                 520                 525             


Ala Cys Asn Ala Ala Tyr Gly Cys Asn Tyr Asn Tyr Asn Cys Cys Asn 
    530                 535                 540                 


Gly Ala Tyr Cys Cys Asn Ala Tyr Gly Ala Arg Trp Ser Asn Gly Ala 
545                 550                 555                 560 


Arg Met Gly Asn Gly Asn Ala Tyr Gly Asn Gly Cys Asn Gly Ala Arg 
                565                 570                 575     


Trp Ser Asn Tyr Asn Ala His Trp Ser Asn Trp Ser Asn Gly Cys Asn 
            580                 585                 590         


Gly Gly Asn Gly Ala Arg Gly Gly Asn Tyr Asn Tyr Trp Ser Asn Ala 
        595                 600                 605             


Ala Arg Gly Asn Gly Cys Asn Gly Asn Gly Gly Asn Cys Cys Asn Ala 
    610                 615                 620                 


Ala Tyr Ala Cys Asn Gly Asn Ala Gly Trp Ser Asn Tyr Ala Tyr Ala 
625                 630                 635                 640 


Ala Tyr Gly Gly Asn Gly Asn Met Gly Asn Ala His Ala Cys Asn Cys 
                645                 650                 655     


Ala Tyr Cys Ala Arg Gly Ala Arg Gly Asn Gly Ala Tyr Trp Ser Asn 
            660                 665                 670         


Met Gly Asn Gly Ala Tyr Gly Gly Gly Cys Asn Tyr Asn Ala Ala Tyr 
        675                 680                 685             


Gly Gly Asn Ala Ala Tyr Ala Cys Asn Tyr Asn Trp Ser Asn Tyr Asn 
    690                 695                 700                 


Gly Ala Tyr Gly Ala Arg Gly Ala Arg Ala Cys Asn Gly Asn Ala His 
705                 710                 715                 720 


Gly Ala Tyr Gly Asn Cys Cys Asn Gly Ala Arg Cys Cys Asn Ala Tyr 
                725                 730                 735     


Ala Ala Tyr Cys Ala Tyr Gly Asn Trp Ser Asn Ala Ala Arg Ala Tyr 
            740                 745                 750         


Gly Tyr Gly Cys Asn Trp Ser Asn Tyr Asn Gly Gly Asn Cys Ala Tyr 
        755                 760                 765             


Ala Ala Arg Gly Cys Asn Ala Ala Tyr Gly Cys Asn Trp Ser Asn Tyr 
    770                 775                 780                 


Ala Cys Asn Cys Cys Asn Ala Ala Tyr Gly Tyr Ala His Ala Tyr Gly 
785                 790                 795                 800 


Ala Tyr Ala Gly Tyr Gly Asn Cys Ala Tyr Cys Cys Asn Met Gly Asn 
                805                 810                 815     


Tyr Gly Gly Asn Cys Cys Asn Ala His Ala Ala Arg Gly Tyr Ala His 
            820                 825                 830         


Met Gly Asn Ala Cys Asn Tyr Asn Met Gly Asn Gly Cys Asn Gly Asn 
        835                 840                 845             


Gly Ala Arg Gly Cys Asn Gly Ala Tyr Gly Ala Arg Gly Ala Arg Tyr 
    850                 855                 860                 


Asn Gly Ala Arg Gly Asn Gly Cys Asn Ala Tyr Gly Gly Asn Ala Tyr 
865                 870                 875                 880 


Gly Ala Tyr Cys Ala Tyr Gly Ala Tyr Cys Cys Asn Cys Cys Asn Gly 
                885                 890                 895     


Gly Asn Ala Ala Arg Gly Ala Tyr Gly Gly Asn Cys Cys Asn Gly Ala 
            900                 905                 910         


Arg Gly Cys Asn Cys Cys Asn Gly Ala Arg Gly Gly Ala Tyr Cys Ala 
        915                 920                 925             


Arg Gly Asn Gly Ala Arg Tyr Asn Ala Ala Arg Gly Cys Asn Tyr Cys 
    930                 935                 940                 


Ala Arg Gly Cys Asn Ala Cys Asn Cys Ala Arg Cys Ala Arg Ala Ala 
945                 950                 955                 960 


Arg 
    


<210>  37
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37

Met Asp Ser Asp Asp Glu Met Val Glu Glu Ala Val Glu Gly His Leu 
1               5                   10                  15      


Asp Asp Asp Gly Leu Pro His Gly Phe Cys Thr Val Thr Tyr Ser Ser 
            20                  25                  30          


Thr Asp Arg Phe Glu Gly Asn Phe Val His Gly Glu Lys Asn Gly Arg 
        35                  40                  45              


Gly Lys Phe Phe Phe Phe Asp Gly Ser Thr Leu Glu Gly Tyr Tyr Val 
    50                  55                  60                  


Asp Asp Ala Leu Gln Gly Gln Gly Val Tyr Thr Tyr Glu Asp Gly Gly 
65                  70                  75                  80  


Val Leu Gln Gly Thr Tyr Val Asp Gly Glu Leu Asn Gly Pro Ala Gln 
                85                  90                  95      


Glu Tyr Asp Thr Asp Gly Arg Leu Ile Phe Lys Gly Gln Tyr Lys Asp 
            100                 105                 110         


Asn Ile Arg His Gly Val Cys Trp Ile Tyr Tyr Pro Asp Gly Gly Ser 
        115                 120                 125             


Leu Val Gly Glu Val Asn Glu Asp Gly Glu Met Thr Gly Glu Lys Ile 
    130                 135                 140                 


Ala Tyr Val Tyr Pro Asp Glu Arg Thr Ala Leu Tyr Gly Lys Phe Ile 
145                 150                 155                 160 


Asp Gly Glu Met Ile Glu Gly Lys Leu Ala Thr Leu Met Ser Thr Glu 
                165                 170                 175     


Glu Gly Arg Pro His Phe Glu Leu Met Pro Gly Asn Ser Val Tyr His 
            180                 185                 190         


Phe Asp Lys Ser Thr Ser Ser Cys Ile Ser Thr Asn Ala Leu Leu Pro 
        195                 200                 205             


Asp Pro Tyr Glu Ser Glu Arg Val Tyr Val Ala Glu Ser Leu Ile Ser 
    210                 215                 220                 


Ser Ala Gly Glu Gly Leu Phe Ser Lys Val Ala Val Gly Pro Asn Thr 
225                 230                 235                 240 


Val Met Ser Phe Tyr Asn Gly Val Arg Ile Thr His Gln Glu Val Asp 
                245                 250                 255     


Ser Arg Asp Trp Ala Leu Asn Gly Asn Thr Leu Ser Leu Asp Glu Glu 
            260                 265                 270         


Thr Val Ile Asp Val Pro Glu Pro Tyr Asn His Val Ser Lys Tyr Cys 
        275                 280                 285             


Ala Ser Leu Gly His Lys Ala Asn His Ser Phe Thr Pro Asn Cys Ile 
    290                 295                 300                 


Tyr Asp Met Phe Val His Pro Arg Phe Gly Pro Ile Lys Cys Ile Arg 
305                 310                 315                 320 


Thr Leu Arg Ala Val Glu Ala Asp Glu Glu Leu Thr Val Ala Tyr Gly 
                325                 330                 335     


Tyr Asp His Ser Pro Pro Gly Lys Ser Gly Pro Glu Ala Pro Glu Trp 
            340                 345                 350         


Tyr Gln Val Glu Leu Lys Ala Phe Gln Ala Thr Gln Gln Lys 
        355                 360                 365     


<210>  38
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phospho-mimicking peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(24)
<223>  Xaa is either Asp or Glu

<400>  38

Ala Asp Glu Glu Leu Xaa Val Ala Tyr Gly Tyr Asp His Xaa Pro Pro 
1               5                   10                  15      


Gly Lys Xaa Gly Pro Glu Ala Pro 
            20                  


<210>  39
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  39
atggatagcg acgacgagat ggtggaggag gcggtggaag ggcacctgga cgatgacgga       60

ttaccgcacg ggttctgcac agtcacctac tcctccacag acagatttga ggggaacttt      120

gttcacggag aaaagaacgg acgggggaag ttcttcttct ttgatggcag caccctggag      180

gggtattatg tggatgatgc cttgcagggc cagggagttt acacttacga agatggggga      240

gttctccagg gcacgtatgt agacggagag ctgaacggtc cagcccagga atatgacaca      300

gatgggagac tgatcttcaa ggggcagtat aaagataaca ttcgtcatgg agtgtgctgg      360

atatattacc cagatggagg aagccttgta ggagaagtaa atgaagatgg ggagatgact      420

ggagagaaga tagcctatgt gtaccctgat gagaggaccg cactttatgg gaaatttatt      480

gatggagaga tgatagaagg caaactggct acccttatgt ccactgaaga agggaggcct      540

cactttgaac tgatgcctgg aaattcagtg taccactttg ataagtcgac ttcatcttgc      600

atttctacca atgctcttct tccagatcct tatgaatcag aaagggttta tgttgctgaa      660

tctcttattt ccagtgctgg agaaggactt ttttcaaagg tagctgtggg acctaatact      720

gttatgtctt tttataatgg agttcgaatt acacaccaag aggttgacag cagggactgg      780

gcccttaatg ggaacaccct ctcccttgat gaagaaacgg tcattgatgt gcctgagccc      840

tataaccacg tatccaagta ctgtgcctcc ttgggacaca aggcaaatca ctccttcact      900

ccaaactgca tctacgatat gtttgtccac ccccgttttg ggcccatcaa atgcatccgc      960

accctgagag cagtggaggc cgatgaagag ctcaccgttg cctatggcta tgaccacagc     1020

ccccccggga agagtgggcc tgaagcccct gagtggtacc aggtggagct gaaggccttc     1080

caggccaccc agcaaaagtg a                                               1101


