                               SEQUENCE LISTING

<110> MAMMOTH BIOSCIENCES, INC.
 
<120> CASY PROGRAMMABLE NUCLEASES AND RNA COMPONENT SYSTEMS

<130> 53694-743.601

<140> PCT/US2021/028481
<141> 2021-04-21

<150> 63/147,567
<151> 2021-02-09

<150> 63/013,332
<151> 2020-04-21

<160> 149   

<170> PatentIn version 3.5

<210> 1
<211> 1125
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY sequence

<400> 1
Met Arg Lys Lys Leu Phe Lys Gly Tyr Ile Leu His Asn Lys Arg Leu 
1               5                   10                  15      


Val Tyr Thr Gly Lys Ala Ala Ile Arg Ser Ile Lys Tyr Pro Leu Val 
            20                  25                  30          


Ala Pro Asn Lys Thr Ala Leu Asn Asn Leu Ser Glu Lys Ile Ile Tyr 
        35                  40                  45              


Asp Tyr Glu His Leu Phe Gly Pro Leu Asn Val Ala Ser Tyr Ala Arg 
    50                  55                  60                  


Asn Ser Asn Arg Tyr Ser Leu Val Asp Phe Trp Ile Asp Ser Leu Arg 
65                  70                  75                  80  


Ala Gly Val Ile Trp Gln Ser Lys Ser Thr Ser Leu Ile Asp Leu Ile 
                85                  90                  95      


Ser Lys Leu Glu Gly Ser Lys Ser Pro Ser Glu Lys Ile Phe Glu Gln 
            100                 105                 110         


Ile Asp Phe Glu Leu Lys Asn Lys Leu Asp Lys Glu Gln Phe Lys Asp 
        115                 120                 125             


Ile Ile Leu Leu Asn Thr Gly Ile Arg Ser Ser Ser Asn Val Arg Ser 
    130                 135                 140                 


Leu Arg Gly Arg Phe Leu Lys Cys Phe Lys Glu Glu Phe Arg Asp Thr 
145                 150                 155                 160 


Glu Glu Val Ile Ala Cys Val Asp Lys Trp Ser Lys Asp Leu Ile Val 
                165                 170                 175     


Glu Gly Lys Ser Ile Leu Val Ser Lys Gln Phe Leu Tyr Trp Glu Glu 
            180                 185                 190         


Glu Phe Gly Ile Lys Ile Phe Pro His Phe Lys Asp Asn His Asp Leu 
        195                 200                 205             


Pro Lys Leu Thr Phe Phe Val Glu Pro Ser Leu Glu Phe Ser Pro His 
    210                 215                 220                 


Leu Pro Leu Ala Asn Cys Leu Glu Arg Leu Lys Lys Phe Asp Ile Ser 
225                 230                 235                 240 


Arg Glu Ser Leu Leu Gly Leu Asp Asn Asn Phe Ser Ala Phe Ser Asn 
                245                 250                 255     


Tyr Phe Asn Glu Leu Phe Asn Leu Leu Ser Arg Gly Glu Ile Lys Lys 
            260                 265                 270         


Ile Val Thr Ala Val Leu Ala Val Ser Lys Ser Trp Glu Asn Glu Pro 
        275                 280                 285             


Glu Leu Glu Lys Arg Leu His Phe Leu Ser Glu Lys Ala Lys Leu Leu 
    290                 295                 300                 


Gly Tyr Pro Lys Leu Thr Ser Ser Trp Ala Asp Tyr Arg Met Ile Ile 
305                 310                 315                 320 


Gly Gly Lys Ile Lys Ser Trp His Ser Asn Tyr Thr Glu Gln Leu Ile 
                325                 330                 335     


Lys Val Arg Glu Asp Leu Lys Lys His Gln Ile Ala Leu Asp Lys Leu 
            340                 345                 350         


Gln Glu Asp Leu Lys Lys Val Val Asp Ser Ser Leu Arg Glu Gln Ile 
        355                 360                 365             


Glu Ala Gln Arg Glu Ala Leu Leu Pro Leu Leu Asp Thr Met Leu Lys 
    370                 375                 380                 


Glu Lys Asp Phe Ser Asp Asp Leu Glu Leu Tyr Arg Phe Ile Leu Ser 
385                 390                 395                 400 


Asp Phe Lys Ser Leu Leu Asn Gly Ser Tyr Gln Arg Tyr Ile Gln Thr 
                405                 410                 415     


Glu Glu Glu Arg Lys Glu Asp Arg Asp Val Thr Lys Lys Tyr Lys Asp 
            420                 425                 430         


Leu Tyr Ser Asn Leu Arg Asn Ile Pro Arg Phe Phe Gly Glu Ser Lys 
        435                 440                 445             


Lys Glu Gln Phe Asn Lys Phe Ile Asn Lys Ser Leu Pro Thr Ile Asp 
    450                 455                 460                 


Val Gly Leu Lys Ile Leu Glu Asp Ile Arg Asn Ala Leu Glu Thr Val 
465                 470                 475                 480 


Ser Val Arg Lys Pro Pro Ser Ile Thr Glu Glu Tyr Val Thr Lys Gln 
                485                 490                 495     


Leu Glu Lys Leu Ser Arg Lys Tyr Lys Ile Asn Ala Phe Asn Ser Asn 
            500                 505                 510         


Arg Phe Lys Gln Ile Thr Glu Gln Val Leu Arg Lys Tyr Asn Asn Gly 
        515                 520                 525             


Glu Leu Pro Lys Ile Ser Glu Val Phe Tyr Arg Tyr Pro Arg Glu Ser 
    530                 535                 540                 


His Val Ala Ile Arg Ile Leu Pro Val Lys Ile Ser Asn Pro Arg Lys 
545                 550                 555                 560 


Asp Ile Ser Tyr Leu Leu Asp Lys Tyr Gln Ile Ser Pro Asp Trp Lys 
                565                 570                 575     


Asn Ser Asn Pro Gly Glu Val Val Asp Leu Ile Glu Ile Tyr Lys Leu 
            580                 585                 590         


Thr Leu Gly Trp Leu Leu Ser Cys Asn Lys Asp Phe Ser Met Asp Phe 
        595                 600                 605             


Ser Ser Tyr Asp Leu Lys Leu Phe Pro Glu Ala Ala Ser Leu Ile Lys 
    610                 615                 620                 


Asn Phe Gly Ser Cys Leu Ser Gly Tyr Tyr Leu Ser Lys Met Ile Phe 
625                 630                 635                 640 


Asn Cys Ile Thr Ser Glu Ile Lys Gly Met Ile Thr Leu Tyr Thr Arg 
                645                 650                 655     


Asp Lys Phe Val Val Arg Tyr Val Thr Gln Met Ile Gly Ser Asn Gln 
            660                 665                 670         


Lys Phe Pro Leu Leu Cys Leu Val Gly Glu Lys Gln Thr Lys Asn Phe 
        675                 680                 685             


Ser Arg Asn Trp Gly Val Leu Ile Glu Glu Lys Gly Asp Leu Gly Glu 
    690                 695                 700                 


Glu Lys Asn Gln Glu Lys Cys Leu Ile Phe Lys Asp Lys Thr Asp Phe 
705                 710                 715                 720 


Ala Lys Ala Lys Glu Val Glu Ile Phe Lys Asn Asn Ile Trp Arg Ile 
                725                 730                 735     


Arg Thr Ser Lys Tyr Gln Ile Gln Phe Leu Asn Arg Leu Phe Lys Lys 
            740                 745                 750         


Thr Lys Glu Trp Asp Leu Met Asn Leu Val Leu Ser Glu Pro Ser Leu 
        755                 760                 765             


Val Leu Glu Glu Glu Trp Gly Val Ser Trp Asp Lys Asp Lys Leu Leu 
    770                 775                 780                 


Pro Leu Leu Lys Lys Glu Lys Ser Cys Glu Glu Arg Leu Tyr Tyr Ser 
785                 790                 795                 800 


Leu Pro Leu Asn Leu Val Pro Ala Thr Asp Tyr Lys Glu Gln Ser Ala 
                805                 810                 815     


Glu Ile Glu Gln Arg Asn Thr Tyr Leu Gly Leu Asp Val Gly Glu Phe 
            820                 825                 830         


Gly Val Ala Tyr Ala Val Val Arg Ile Val Arg Asp Arg Ile Glu Leu 
        835                 840                 845             


Leu Ser Trp Gly Phe Leu Lys Asp Pro Ala Leu Arg Lys Ile Arg Glu 
    850                 855                 860                 


Arg Val Gln Asp Met Lys Lys Lys Gln Val Met Ala Val Phe Ser Ser 
865                 870                 875                 880 


Ser Ser Thr Ala Val Ala Arg Val Arg Glu Met Ala Ile His Ser Leu 
                885                 890                 895     


Arg Asn Gln Ile His Ser Ile Ala Leu Ala Tyr Lys Ala Lys Ile Ile 
            900                 905                 910         


Tyr Glu Ile Ser Ile Ser Asn Phe Glu Thr Gly Gly Asn Arg Met Ala 
        915                 920                 925             


Lys Ile Tyr Arg Ser Ile Lys Val Ser Asp Val Tyr Arg Glu Ser Gly 
    930                 935                 940                 


Ala Asp Thr Leu Val Ser Glu Met Ile Trp Gly Lys Lys Asn Lys Gln 
945                 950                 955                 960 


Met Gly Asn His Ile Ser Ser Tyr Ala Thr Ser Tyr Thr Cys Cys Asn 
                965                 970                 975     


Cys Ala Arg Thr Pro Phe Glu Leu Val Ile Asp Asn Asp Lys Glu Tyr 
            980                 985                 990         


Glu Lys Gly Gly Asp Glu Phe Ile  Phe Asn Val Gly Asp  Glu Lys Lys 
        995                 1000                 1005             


Val Arg  Gly Phe Leu Gln Lys  Ser Leu Leu Gly Lys  Thr Ile Lys 
    1010                 1015                 1020             


Gly Lys  Glu Val Leu Lys Ser  Ile Lys Glu Tyr Ala  Arg Pro Pro 
    1025                 1030                 1035             


Ile Arg  Glu Val Leu Leu Glu  Gly Glu Asp Val Glu  Gln Leu Leu 
    1040                 1045                 1050             


Lys Arg  Arg Gly Asn Ser Tyr  Ile Tyr Arg Cys Pro  Phe Cys Gly 
    1055                 1060                 1065             


Tyr Lys  Thr Asp Ala Asp Ile  Gln Ala Ala Leu Asn  Ile Ala Cys 
    1070                 1075                 1080             


Arg Gly  Tyr Ile Ser Asp Asn  Ala Lys Asp Ala Val  Lys Glu Gly 
    1085                 1090                 1095             


Glu Arg  Lys Leu Asp Tyr Ile  Leu Glu Val Arg Lys  Leu Trp Glu 
    1100                 1105                 1110             


Lys Asn  Gly Ala Val Leu Arg  Ser Ala Lys Phe Leu  
    1115                 1120                 1125 


<210> 2
<211> 1226
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY sequence

<400> 2
Met Gln Lys Val Arg Lys Thr Leu Ser Glu Val His Lys Asn Pro Tyr 
1               5                   10                  15      


Gly Thr Lys Val Arg Asn Ala Lys Thr Gly Tyr Ser Leu Gln Ile Glu 
            20                  25                  30          


Arg Leu Ser Tyr Thr Gly Lys Glu Gly Met Arg Ser Phe Lys Ile Pro 
        35                  40                  45              


Leu Glu Asn Lys Asn Lys Glu Val Phe Asp Glu Phe Val Lys Lys Ile 
    50                  55                  60                  


Arg Asn Asp Tyr Ile Ser Gln Val Gly Leu Leu Asn Leu Ser Asp Trp 
65                  70                  75                  80  


Tyr Glu His Tyr Gln Glu Lys Gln Glu His Tyr Ser Leu Ala Asp Phe 
                85                  90                  95      


Trp Leu Asp Ser Leu Arg Ala Gly Val Ile Phe Ala His Lys Glu Thr 
            100                 105                 110         


Glu Ile Lys Asn Leu Ile Ser Lys Ile Arg Gly Asp Lys Ser Ile Val 
        115                 120                 125             


Asp Lys Phe Asn Ala Ser Ile Lys Lys Lys His Ala Asp Leu Tyr Ala 
    130                 135                 140                 


Leu Val Asp Ile Lys Ala Leu Tyr Asp Phe Leu Thr Ser Asp Ala Arg 
145                 150                 155                 160 


Arg Gly Leu Lys Thr Glu Glu Glu Phe Phe Asn Ser Lys Arg Asn Thr 
                165                 170                 175     


Leu Phe Pro Lys Phe Arg Lys Lys Asp Asn Lys Ala Val Asp Leu Trp 
            180                 185                 190         


Val Lys Lys Phe Ile Gly Leu Asp Asn Lys Asp Lys Leu Asn Phe Thr 
        195                 200                 205             


Lys Lys Phe Ile Gly Phe Asp Pro Asn Pro Gln Ile Lys Tyr Asp His 
    210                 215                 220                 


Thr Phe Phe Phe His Gln Asp Ile Asn Phe Asp Leu Glu Arg Ile Thr 
225                 230                 235                 240 


Thr Pro Lys Glu Leu Ile Ser Thr Tyr Lys Lys Phe Leu Gly Lys Asn 
                245                 250                 255     


Lys Asp Leu Tyr Gly Ser Asp Glu Thr Thr Glu Asp Gln Leu Lys Met 
            260                 265                 270         


Val Leu Gly Phe His Asn Asn His Gly Ala Phe Ser Lys Tyr Phe Asn 
        275                 280                 285             


Ala Ser Leu Glu Ala Phe Arg Gly Arg Asp Asn Ser Leu Val Glu Gln 
    290                 295                 300                 


Ile Ile Asn Asn Ser Pro Tyr Trp Asn Ser His Arg Lys Glu Leu Glu 
305                 310                 315                 320 


Lys Arg Ile Ile Phe Leu Gln Val Gln Ser Lys Lys Ile Lys Glu Thr 
                325                 330                 335     


Glu Leu Gly Lys Pro His Glu Tyr Leu Ala Ser Phe Gly Gly Lys Phe 
            340                 345                 350         


Glu Ser Trp Val Ser Asn Tyr Leu Arg Gln Glu Glu Glu Val Lys Arg 
        355                 360                 365             


Gln Leu Phe Gly Tyr Glu Glu Asn Lys Lys Gly Gln Lys Lys Phe Ile 
    370                 375                 380                 


Val Gly Asn Lys Gln Glu Leu Asp Lys Ile Ile Arg Gly Thr Asp Glu 
385                 390                 395                 400 


Tyr Glu Ile Lys Ala Ile Ser Lys Glu Thr Ile Gly Leu Thr Gln Lys 
                405                 410                 415     


Cys Leu Lys Leu Leu Glu Gln Leu Lys Asp Ser Val Asp Asp Tyr Thr 
            420                 425                 430         


Leu Ser Leu Tyr Arg Gln Leu Ile Val Glu Leu Arg Ile Arg Leu Asn 
        435                 440                 445             


Val Glu Phe Gln Glu Thr Tyr Pro Glu Leu Ile Gly Lys Ser Glu Lys 
    450                 455                 460                 


Asp Lys Glu Lys Asp Ala Lys Asn Lys Arg Ala Asp Lys Arg Tyr Pro 
465                 470                 475                 480 


Gln Ile Phe Lys Asp Ile Lys Leu Ile Pro Asn Phe Leu Gly Glu Thr 
                485                 490                 495     


Lys Gln Met Val Tyr Lys Lys Phe Ile Arg Ser Ala Asp Ile Leu Tyr 
            500                 505                 510         


Glu Gly Ile Asn Phe Ile Asp Gln Ile Asp Lys Gln Ile Thr Gln Asn 
        515                 520                 525             


Leu Leu Pro Cys Phe Lys Asn Asp Lys Glu Arg Ile Glu Phe Thr Glu 
    530                 535                 540                 


Lys Gln Phe Glu Thr Leu Arg Arg Lys Tyr Tyr Leu Met Asn Ser Ser 
545                 550                 555                 560 


Arg Phe His His Val Ile Glu Gly Ile Ile Asn Asn Arg Lys Leu Ile 
                565                 570                 575     


Glu Met Lys Lys Arg Glu Asn Ser Glu Leu Lys Thr Phe Ser Asp Ser 
            580                 585                 590         


Lys Phe Val Leu Ser Lys Leu Phe Leu Lys Lys Gly Lys Lys Tyr Glu 
        595                 600                 605             


Asn Glu Val Tyr Tyr Thr Phe Tyr Ile Asn Pro Lys Ala Arg Asp Gln 
    610                 615                 620                 


Arg Arg Ile Lys Ile Val Leu Asp Ile Asn Gly Asn Asn Ser Val Gly 
625                 630                 635                 640 


Ile Leu Gln Asp Leu Val Gln Lys Leu Lys Pro Lys Trp Asp Asp Ile 
                645                 650                 655     


Ile Lys Lys Asn Asp Met Gly Glu Leu Ile Asp Ala Ile Glu Ile Glu 
            660                 665                 670         


Lys Val Arg Leu Gly Ile Leu Ile Ala Leu Tyr Cys Glu His Lys Phe 
        675                 680                 685             


Lys Ile Lys Lys Glu Leu Leu Ser Leu Asp Leu Phe Ala Ser Ala Tyr 
    690                 695                 700                 


Gln Tyr Leu Glu Leu Glu Asp Asp Pro Glu Glu Leu Ser Gly Thr Asn 
705                 710                 715                 720 


Leu Gly Arg Phe Leu Gln Ser Leu Val Cys Ser Glu Ile Lys Gly Ala 
                725                 730                 735     


Ile Asn Lys Ile Ser Arg Thr Glu Tyr Ile Glu Arg Tyr Thr Val Gln 
            740                 745                 750         


Pro Met Asn Thr Glu Lys Asn Tyr Pro Leu Leu Ile Asn Lys Glu Gly 
        755                 760                 765             


Lys Ala Thr Trp His Ile Ala Ala Lys Asp Asp Leu Ser Lys Lys Lys 
    770                 775                 780                 


Gly Gly Gly Thr Val Ala Met Asn Gln Lys Ile Gly Lys Asn Phe Phe 
785                 790                 795                 800 


Gly Lys Gln Asp Tyr Lys Thr Val Phe Met Leu Gln Asp Lys Arg Phe 
                805                 810                 815     


Asp Leu Leu Thr Ser Lys Tyr His Leu Gln Phe Leu Ser Lys Thr Leu 
            820                 825                 830         


Asp Thr Gly Gly Gly Ser Trp Trp Lys Asn Lys Asn Ile Asp Leu Asn 
        835                 840                 845             


Leu Ser Ser Tyr Ser Phe Ile Phe Glu Gln Lys Val Lys Val Glu Trp 
    850                 855                 860                 


Asp Leu Thr Asn Leu Asp His Pro Ile Lys Ile Lys Pro Ser Glu Asn 
865                 870                 875                 880 


Ser Asp Asp Arg Arg Leu Phe Val Ser Ile Pro Phe Val Ile Lys Pro 
                885                 890                 895     


Lys Gln Thr Lys Arg Lys Asp Leu Gln Thr Arg Val Asn Tyr Met Gly 
            900                 905                 910         


Ile Asp Ile Gly Glu Tyr Gly Leu Ala Trp Thr Ile Ile Asn Ile Asp 
        915                 920                 925             


Leu Lys Asn Lys Lys Ile Asn Lys Ile Ser Lys Gln Gly Phe Ile Tyr 
    930                 935                 940                 


Glu Pro Leu Thr His Lys Val Arg Asp Tyr Val Ala Thr Ile Lys Asp 
945                 950                 955                 960 


Asn Gln Val Arg Gly Thr Phe Gly Met Pro Asp Thr Lys Leu Ala Arg 
                965                 970                 975     


Leu Arg Glu Asn Ala Ile Thr Ser Leu Arg Asn Gln Val His Asp Ile 
            980                 985                 990         


Ala Met Arg Tyr Asp Ala Lys Pro  Val Tyr Glu Phe Glu  Ile Ser Asn 
        995                 1000                 1005             


Phe Glu  Thr Gly Ser Asn Lys  Val Lys Val Ile Tyr  Asp Ser Val 
    1010                 1015                 1020             


Lys Arg  Ala Asp Ile Gly Arg  Gly Gln Asn Asn Thr  Glu Ala Asp 
    1025                 1030                 1035             


Asn Thr  Glu Val Asn Leu Val  Trp Gly Lys Thr Ser  Lys Gln Phe 
    1040                 1045                 1050             


Gly Ser  Gln Ile Gly Ala Tyr  Ala Thr Ser Tyr Ile  Cys Ser Phe 
    1055                 1060                 1065             


Cys Gly  Tyr Ser Pro Tyr Tyr  Glu Phe Glu Asn Ser  Lys Ser Gly 
    1070                 1075                 1080             


Asp Glu  Glu Gly Ala Arg Asp  Asn Leu Tyr Gln Met  Lys Lys Leu 
    1085                 1090                 1095             


Ser Arg  Pro Ser Leu Glu Asp  Phe Leu Gln Gly Asn  Pro Val Tyr 
    1100                 1105                 1110             


Lys Thr  Phe Arg Asp Phe Asp  Lys Tyr Lys Asn Asp  Gln Arg Leu 
    1115                 1120                 1125             


Gln Lys  Thr Gly Asp Lys Asp  Gly Glu Trp Lys Thr  His Arg Gly 
    1130                 1135                 1140             


Asn Thr  Ala Ile Tyr Ala Cys  Gln Lys Cys Arg His  Ile Ser Asp 
    1145                 1150                 1155             


Ala Asp  Ile Gln Ala Ser Tyr  Trp Ile Ala Leu Lys  Gln Val Val 
    1160                 1165                 1170             


Arg Asp  Phe Tyr Lys Asp Lys  Glu Met Asp Gly Asp  Leu Ile Gln 
    1175                 1180                 1185             


Gly Asp  Asn Lys Asp Lys Arg  Lys Val Asn Glu Leu  Asn Arg Leu 
    1190                 1195                 1200             


Ile Gly  Val His Lys Asp Val  Pro Ile Ile Asn Lys  Asn Leu Ile 
    1205                 1210                 1215             


Thr Ser  Leu Asp Ile Asn Leu  Leu 
    1220                 1225     


<210> 3
<211> 1201
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY3 sequence

<400> 3
Met Lys Ala Lys Lys Ser Phe Tyr Asn Gln Lys Arg Lys Phe Gly Lys 
1               5                   10                  15      


Arg Gly Tyr Arg Leu His Asp Glu Arg Ile Ala Tyr Ser Gly Gly Ile 
            20                  25                  30          


Gly Ser Met Arg Ser Ile Lys Tyr Glu Leu Lys Asp Ser Tyr Gly Ile 
        35                  40                  45              


Ala Gly Leu Arg Asn Arg Ile Ala Asp Ala Thr Ile Ser Asp Asn Lys 
    50                  55                  60                  


Trp Leu Tyr Gly Asn Ile Asn Leu Asn Asp Tyr Leu Glu Trp Arg Ser 
65                  70                  75                  80  


Ser Lys Thr Asp Lys Gln Ile Glu Asp Gly Asp Arg Glu Ser Ser Leu 
                85                  90                  95      


Leu Gly Phe Trp Leu Glu Ala Leu Arg Leu Gly Phe Val Phe Ser Lys 
            100                 105                 110         


Gln Ser His Ala Pro Asn Asp Phe Asn Glu Thr Ala Leu Gln Asp Leu 
        115                 120                 125             


Phe Glu Thr Leu Asp Asp Asp Leu Lys His Val Leu Asp Arg Lys Lys 
    130                 135                 140                 


Trp Cys Asp Phe Ile Lys Ile Gly Thr Pro Lys Thr Asn Asp Gln Gly 
145                 150                 155                 160 


Arg Leu Lys Lys Gln Ile Lys Asn Leu Leu Lys Gly Asn Lys Arg Glu 
                165                 170                 175     


Glu Ile Glu Lys Thr Leu Asn Glu Ser Asp Asp Glu Leu Lys Glu Lys 
            180                 185                 190         


Ile Asn Arg Ile Ala Asp Val Phe Ala Lys Asn Lys Ser Asp Lys Tyr 
        195                 200                 205             


Thr Ile Phe Lys Leu Asp Lys Pro Asn Thr Glu Lys Tyr Pro Arg Ile 
    210                 215                 220                 


Asn Asp Val Gln Val Ala Phe Phe Cys His Pro Asp Phe Glu Glu Ile 
225                 230                 235                 240 


Thr Glu Arg Asp Arg Thr Lys Thr Leu Asp Leu Ile Ile Asn Arg Phe 
                245                 250                 255     


Asn Lys Arg Tyr Glu Ile Thr Glu Asn Lys Lys Asp Asp Lys Thr Ser 
            260                 265                 270         


Asn Arg Met Ala Leu Tyr Ser Leu Asn Gln Gly Tyr Ile Pro Arg Val 
        275                 280                 285             


Leu Asn Asp Leu Phe Leu Phe Val Lys Asp Asn Glu Asp Asp Phe Ser 
    290                 295                 300                 


Gln Phe Leu Ser Asp Leu Glu Asn Phe Phe Ser Phe Ser Asn Glu Gln 
305                 310                 315                 320 


Ile Lys Ile Ile Lys Glu Arg Leu Lys Lys Leu Lys Lys Tyr Ala Glu 
                325                 330                 335     


Pro Ile Pro Gly Lys Pro Gln Leu Ala Asp Lys Trp Asp Asp Tyr Ala 
            340                 345                 350         


Ser Asp Phe Gly Gly Lys Leu Glu Ser Trp Tyr Ser Asn Arg Ile Glu 
        355                 360                 365             


Lys Leu Lys Lys Ile Pro Glu Ser Val Ser Asp Leu Arg Asn Asn Leu 
    370                 375                 380                 


Glu Lys Ile Arg Asn Val Leu Lys Lys Gln Asn Asn Ala Ser Lys Ile 
385                 390                 395                 400 


Leu Glu Leu Ser Gln Lys Ile Ile Glu Tyr Ile Arg Asp Tyr Gly Val 
                405                 410                 415     


Ser Phe Glu Lys Pro Glu Ile Ile Lys Phe Ser Trp Ile Asn Lys Thr 
            420                 425                 430         


Lys Asp Gly Gln Lys Lys Val Phe Tyr Val Ala Lys Met Ala Asp Arg 
        435                 440                 445             


Glu Phe Ile Glu Lys Leu Asp Leu Trp Met Ala Asp Leu Arg Ser Gln 
    450                 455                 460                 


Leu Asn Glu Tyr Asn Gln Asp Asn Lys Val Ser Phe Lys Lys Lys Gly 
465                 470                 475                 480 


Lys Lys Ile Glu Glu Leu Gly Val Leu Asp Phe Ala Leu Asn Lys Ala 
                485                 490                 495     


Lys Lys Asn Lys Ser Thr Lys Asn Glu Asn Gly Trp Gln Gln Lys Leu 
            500                 505                 510         


Ser Glu Ser Ile Gln Ser Ala Pro Leu Phe Phe Gly Glu Gly Asn Arg 
        515                 520                 525             


Val Arg Asn Glu Glu Val Tyr Asn Leu Lys Asp Leu Leu Phe Ser Glu 
    530                 535                 540                 


Ile Lys Asn Val Glu Asn Ile Leu Met Ser Ser Glu Ala Glu Asp Leu 
545                 550                 555                 560 


Lys Asn Ile Lys Ile Glu Tyr Lys Glu Asp Gly Ala Lys Lys Gly Asn 
                565                 570                 575     


Tyr Val Leu Asn Val Leu Ala Arg Phe Tyr Ala Arg Phe Asn Glu Asp 
            580                 585                 590         


Gly Tyr Gly Gly Trp Asn Lys Val Lys Thr Val Leu Glu Asn Ile Ala 
        595                 600                 605             


Arg Glu Ala Gly Thr Asp Phe Ser Lys Tyr Gly Asn Asn Asn Asn Arg 
    610                 615                 620                 


Asn Ala Gly Arg Phe Tyr Leu Asn Gly Arg Glu Arg Gln Val Phe Thr 
625                 630                 635                 640 


Leu Ile Lys Phe Glu Lys Ser Ile Thr Val Glu Lys Ile Leu Glu Leu 
                645                 650                 655     


Val Lys Leu Pro Ser Leu Leu Asp Glu Ala Tyr Arg Asp Leu Val Asn 
            660                 665                 670         


Glu Asn Lys Asn His Lys Leu Arg Asp Val Ile Gln Leu Ser Lys Thr 
        675                 680                 685             


Ile Met Ala Leu Val Leu Ser His Ser Asp Lys Glu Lys Gln Ile Gly 
    690                 695                 700                 


Gly Asn Tyr Ile His Ser Lys Leu Ser Gly Tyr Asn Ala Leu Ile Ser 
705                 710                 715                 720 


Lys Arg Asp Phe Ile Ser Arg Tyr Ser Val Gln Thr Thr Asn Gly Thr 
                725                 730                 735     


Gln Cys Lys Leu Ala Ile Gly Lys Gly Lys Ser Lys Lys Gly Asn Glu 
            740                 745                 750         


Ile Asp Arg Tyr Phe Tyr Ala Phe Gln Phe Phe Lys Asn Asp Asp Ser 
        755                 760                 765             


Lys Ile Asn Leu Lys Val Ile Lys Asn Asn Ser His Lys Asn Ile Asp 
    770                 775                 780                 


Phe Asn Asp Asn Glu Asn Lys Ile Asn Ala Leu Gln Val Tyr Ser Ser 
785                 790                 795                 800 


Asn Tyr Gln Ile Gln Phe Leu Asp Trp Phe Phe Glu Lys His Gln Gly 
                805                 810                 815     


Lys Lys Thr Ser Leu Glu Val Gly Gly Ser Phe Thr Ile Ala Glu Lys 
            820                 825                 830         


Ser Leu Thr Ile Asp Trp Ser Gly Ser Asn Pro Arg Val Gly Phe Lys 
        835                 840                 845             


Arg Ser Asp Thr Glu Glu Lys Arg Val Phe Val Ser Gln Pro Phe Thr 
    850                 855                 860                 


Leu Ile Pro Asp Asp Glu Asp Lys Glu Arg Arg Lys Glu Arg Met Ile 
865                 870                 875                 880 


Lys Thr Lys Asn Arg Phe Ile Gly Ile Asp Ile Gly Glu Tyr Gly Leu 
                885                 890                 895     


Ala Trp Ser Leu Ile Glu Val Asp Asn Gly Asp Lys Asn Asn Arg Gly 
            900                 905                 910         


Ile Arg Gln Leu Glu Ser Gly Phe Ile Thr Asp Asn Gln Gln Gln Val 
        915                 920                 925             


Leu Lys Lys Asn Val Lys Ser Trp Arg Gln Asn Gln Ile Arg Gln Thr 
    930                 935                 940                 


Phe Thr Ser Pro Asp Thr Lys Ile Ala Arg Leu Arg Glu Ser Leu Ile 
945                 950                 955                 960 


Gly Ser Tyr Lys Asn Gln Leu Glu Ser Leu Met Val Ala Lys Lys Ala 
                965                 970                 975     


Asn Leu Ser Phe Glu Tyr Glu Val Ser Gly Phe Glu Val Gly Gly Lys 
            980                 985                 990         


Arg Val Ala Lys Ile Tyr Asp Ser  Ile Lys Arg Gly Ser  Val Arg Lys 
        995                 1000                 1005             


Lys Asp  Asn Asn Ser Gln Asn  Asp Gln Ser Trp Gly  Lys Lys Gly 
    1010                 1015                 1020             


Ile Asn  Glu Trp Ser Phe Glu  Thr Thr Ala Ala Gly  Thr Ser Gln 
    1025                 1030                 1035             


Phe Cys  Thr His Cys Lys Arg  Trp Ser Ser Leu Ala  Ile Val Asp 
    1040                 1045                 1050             


Ile Glu  Glu Tyr Glu Leu Lys  Asp Tyr Asn Asp Asn  Leu Phe Lys 
    1055                 1060                 1065             


Val Lys  Ile Asn Asp Gly Glu  Val Arg Leu Leu Gly  Lys Lys Gly 
    1070                 1075                 1080             


Trp Arg  Ser Gly Glu Lys Ile  Lys Gly Lys Glu Leu  Phe Gly Pro 
    1085                 1090                 1095             


Val Lys  Asp Ala Met Arg Pro  Asn Val Asp Gly Leu  Gly Met Lys 
    1100                 1105                 1110             


Ile Val  Lys Arg Lys Tyr Leu  Lys Leu Asp Leu Arg  Asp Trp Val 
    1115                 1120                 1125             


Ser Arg  Tyr Gly Asn Met Ala  Ile Phe Ile Cys Pro  Tyr Val Asp 
    1130                 1135                 1140             


Cys His  His Ile Ser His Ala  Asp Lys Gln Ala Ala  Phe Asn Ile 
    1145                 1150                 1155             


Ala Val  Arg Gly Tyr Leu Lys  Ser Val Asn Pro Asp  Arg Ala Ile 
    1160                 1165                 1170             


Lys His  Gly Asp Lys Gly Leu  Ser Arg Asp Phe Leu  Cys Gln Glu 
    1175                 1180                 1185             


Glu Gly  Lys Leu Asn Phe Glu  Gln Ile Gly Leu Leu  Ile 
    1190                 1195                 1200     


<210> 4
<211> 1210
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY sequence

<400> 4
Met Ser Lys Arg His Pro Arg Ile Ser Gly Val Lys Gly Tyr Arg Leu 
1               5                   10                  15      


His Ala Gln Arg Leu Glu Tyr Thr Gly Lys Ser Gly Ala Met Arg Thr 
            20                  25                  30          


Ile Lys Tyr Pro Leu Tyr Ser Ser Pro Ser Gly Gly Arg Thr Val Pro 
        35                  40                  45              


Arg Glu Ile Val Ser Ala Ile Asn Asp Asp Tyr Val Gly Leu Tyr Gly 
    50                  55                  60                  


Leu Ser Asn Phe Asp Asp Leu Tyr Asn Ala Glu Lys Arg Asn Glu Glu 
65                  70                  75                  80  


Lys Val Tyr Ser Val Leu Asp Phe Trp Tyr Asp Cys Val Gln Tyr Gly 
                85                  90                  95      


Ala Val Phe Ser Tyr Thr Ala Pro Gly Leu Leu Lys Asn Val Ala Glu 
            100                 105                 110         


Val Arg Gly Gly Ser Tyr Glu Leu Thr Lys Thr Leu Lys Gly Ser His 
        115                 120                 125             


Leu Tyr Asp Glu Leu Gln Ile Asp Lys Val Ile Lys Phe Leu Asn Lys 
    130                 135                 140                 


Lys Glu Ile Ser Arg Ala Asn Gly Ser Leu Asp Lys Leu Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Asp Cys Phe Lys Ala Glu Tyr Arg Glu Arg His Lys Asp Gln 
                165                 170                 175     


Cys Asn Lys Leu Ala Asp Asp Ile Lys Asn Ala Lys Lys Asp Ala Gly 
            180                 185                 190         


Ala Ser Leu Gly Glu Arg Gln Lys Lys Leu Phe Arg Asp Phe Phe Gly 
        195                 200                 205             


Ile Ser Glu Gln Ser Glu Asn Asp Lys Pro Ser Phe Thr Asn Pro Leu 
    210                 215                 220                 


Asn Leu Thr Cys Cys Leu Leu Pro Phe Asp Thr Val Asn Asn Asn Arg 
225                 230                 235                 240 


Asn Arg Gly Glu Val Leu Phe Asn Lys Leu Lys Glu Tyr Ala Gln Lys 
                245                 250                 255     


Leu Asp Lys Asn Glu Gly Ser Leu Glu Met Trp Glu Tyr Ile Gly Ile 
            260                 265                 270         


Gly Asn Ser Gly Thr Ala Phe Ser Asn Phe Leu Gly Glu Gly Phe Leu 
        275                 280                 285             


Gly Arg Leu Arg Glu Asn Lys Ile Thr Glu Leu Lys Lys Ala Met Met 
    290                 295                 300                 


Asp Ile Thr Asp Ala Trp Arg Gly Gln Glu Gln Glu Glu Glu Leu Glu 
305                 310                 315                 320 


Lys Arg Leu Arg Ile Leu Ala Ala Leu Thr Ile Lys Leu Arg Glu Pro 
                325                 330                 335     


Lys Phe Asp Asn His Trp Gly Gly Tyr Arg Ser Asp Ile Asn Gly Lys 
            340                 345                 350         


Leu Ser Ser Trp Leu Gln Asn Tyr Ile Asn Gln Thr Val Lys Ile Lys 
        355                 360                 365             


Glu Asp Leu Lys Gly His Lys Lys Asp Leu Lys Lys Ala Lys Glu Met 
    370                 375                 380                 


Ile Asn Arg Phe Gly Glu Ser Asp Thr Lys Glu Glu Ala Val Val Ser 
385                 390                 395                 400 


Ser Leu Leu Glu Ser Ile Glu Lys Ile Val Pro Asp Asp Ser Ala Asp 
                405                 410                 415     


Asp Glu Lys Pro Asp Ile Pro Ala Ile Ala Ile Tyr Arg Arg Phe Leu 
            420                 425                 430         


Ser Asp Gly Arg Leu Thr Leu Asn Arg Phe Val Gln Arg Glu Asp Val 
        435                 440                 445             


Gln Glu Ala Leu Ile Lys Glu Arg Leu Glu Ala Glu Lys Lys Lys Lys 
    450                 455                 460                 


Pro Lys Lys Arg Lys Lys Lys Ser Asp Ala Glu Asp Glu Lys Glu Thr 
465                 470                 475                 480 


Ile Asp Phe Lys Glu Leu Phe Pro His Leu Ala Lys Pro Leu Lys Leu 
                485                 490                 495     


Val Pro Asn Phe Tyr Gly Asp Ser Lys Arg Glu Leu Tyr Lys Lys Tyr 
            500                 505                 510         


Lys Asn Ala Ala Ile Tyr Thr Asp Ala Leu Trp Lys Ala Val Glu Lys 
        515                 520                 525             


Ile Tyr Lys Ser Ala Phe Ser Ser Ser Leu Lys Asn Ser Phe Phe Asp 
    530                 535                 540                 


Thr Asp Phe Asp Lys Asp Phe Phe Ile Lys Arg Leu Gln Lys Ile Phe 
545                 550                 555                 560 


Ser Val Tyr Arg Arg Phe Asn Thr Asp Lys Trp Lys Pro Ile Val Lys 
                565                 570                 575     


Asn Ser Phe Ala Pro Tyr Cys Asp Ile Val Ser Leu Ala Glu Asn Glu 
            580                 585                 590         


Val Leu Tyr Lys Pro Lys Gln Ser Arg Ser Arg Lys Ser Ala Ala Ile 
        595                 600                 605             


Asp Lys Asn Arg Val Arg Leu Pro Ser Thr Glu Asn Ile Ala Lys Ala 
    610                 615                 620                 


Gly Ile Ala Leu Ala Arg Glu Leu Ser Val Ala Gly Phe Asp Trp Lys 
625                 630                 635                 640 


Asp Leu Leu Lys Lys Glu Glu His Glu Glu Tyr Ile Asp Leu Ile Glu 
                645                 650                 655     


Leu His Lys Thr Ala Leu Ala Leu Leu Leu Ala Val Thr Glu Thr Gln 
            660                 665                 670         


Leu Asp Ile Ser Ala Leu Asp Phe Val Glu Asn Gly Thr Val Lys Asp 
        675                 680                 685             


Phe Met Lys Thr Arg Asp Gly Asn Leu Val Leu Glu Gly Arg Phe Leu 
    690                 695                 700                 


Glu Met Phe Ser Gln Ser Ile Val Phe Ser Glu Leu Arg Gly Leu Ala 
705                 710                 715                 720 


Gly Leu Met Ser Arg Lys Glu Phe Ile Thr Arg Ser Ala Ile Gln Thr 
                725                 730                 735     


Met Asn Gly Lys Gln Ala Glu Leu Leu Tyr Ile Pro His Glu Phe Gln 
            740                 745                 750         


Ser Ala Lys Ile Thr Thr Pro Lys Glu Met Ser Arg Ala Phe Leu Asp 
        755                 760                 765             


Leu Ala Pro Ala Glu Phe Ala Thr Ser Leu Glu Pro Glu Ser Leu Ser 
    770                 775                 780                 


Glu Lys Ser Leu Leu Lys Leu Lys Gln Met Arg Tyr Tyr Pro His Tyr 
785                 790                 795                 800 


Phe Gly Tyr Glu Leu Thr Arg Thr Gly Gln Gly Ile Asp Gly Gly Val 
                805                 810                 815     


Ala Glu Asn Ala Leu Arg Leu Glu Lys Ser Pro Val Lys Lys Arg Glu 
            820                 825                 830         


Ile Lys Cys Lys Gln Tyr Lys Thr Leu Gly Arg Gly Gln Asn Lys Ile 
        835                 840                 845             


Val Leu Tyr Val Arg Ser Ser Tyr Tyr Gln Thr Gln Phe Leu Glu Trp 
    850                 855                 860                 


Phe Leu His Arg Pro Lys Asn Val Gln Thr Asp Val Ala Val Ser Gly 
865                 870                 875                 880 


Ser Phe Leu Ile Asp Glu Lys Lys Val Lys Thr Arg Trp Asn Tyr Asp 
                885                 890                 895     


Ala Leu Thr Val Ala Leu Glu Pro Val Ser Gly Ser Glu Arg Val Phe 
            900                 905                 910         


Val Ser Gln Pro Phe Thr Ile Phe Pro Glu Lys Ser Ala Glu Glu Glu 
        915                 920                 925             


Gly Gln Arg Tyr Leu Gly Ile Asp Ile Gly Glu Tyr Gly Ile Ala Tyr 
    930                 935                 940                 


Thr Ala Leu Glu Ile Thr Gly Asp Ser Ala Lys Ile Leu Asp Gln Asn 
945                 950                 955                 960 


Phe Ile Ser Asp Pro Gln Leu Lys Thr Leu Arg Glu Glu Val Lys Gly 
                965                 970                 975     


Leu Lys Leu Asp Gln Arg Arg Gly Thr Phe Ala Met Pro Ser Thr Lys 
            980                 985                 990         


Ile Ala Arg Ile Arg Glu Ser Leu  Val His Ser Leu Arg  Asn Arg Ile 
        995                 1000                 1005             


His His  Leu Ala Leu Lys His  Lys Ala Lys Ile Val  Tyr Glu Leu 
    1010                 1015                 1020             


Glu Val  Ser Arg Phe Glu Glu  Gly Lys Gln Lys Ile  Lys Lys Val 
    1025                 1030                 1035             


Tyr Ala  Thr Leu Lys Lys Ala  Asp Val Tyr Ser Glu  Ile Asp Ala 
    1040                 1045                 1050             


Asp Lys  Asn Leu Gln Thr Thr  Val Trp Gly Lys Leu  Ala Val Ala 
    1055                 1060                 1065             


Ser Glu  Ile Ser Ala Ser Tyr  Thr Ser Gln Phe Cys  Gly Ala Cys 
    1070                 1075                 1080             


Lys Lys  Leu Trp Arg Ala Glu  Met Gln Val Asp Glu  Thr Ile Thr 
    1085                 1090                 1095             


Thr Gln  Glu Leu Ile Gly Thr  Val Arg Val Ile Lys  Gly Gly Thr 
    1100                 1105                 1110             


Leu Ile  Asp Ala Ile Lys Asp  Phe Met Arg Pro Pro  Ile Phe Asp 
    1115                 1120                 1125             


Glu Asn  Asp Thr Pro Phe Pro  Lys Tyr Arg Asp Phe  Cys Asp Lys 
    1130                 1135                 1140             


His His  Ile Ser Lys Lys Met  Arg Gly Asn Ser Cys  Leu Phe Ile 
    1145                 1150                 1155             


Cys Pro  Phe Cys Arg Ala Asn  Ala Asp Ala Asp Ile  Gln Ala Ser 
    1160                 1165                 1170             


Gln Thr  Ile Ala Leu Leu Arg  Tyr Val Lys Glu Glu  Lys Lys Val 
    1175                 1180                 1185             


Glu Asp  Tyr Phe Glu Arg Phe  Arg Lys Leu Lys Asn  Ile Lys Val 
    1190                 1195                 1200             


Leu Gly  Gln Met Lys Lys Ile  
    1205                 1210 


<210> 5
<211> 1287
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY sequence

<400> 5
Met Lys Arg Ile Leu Asn Ser Leu Lys Val Ala Ala Leu Arg Leu Leu 
1               5                   10                  15      


Phe Arg Gly Lys Gly Ser Glu Leu Val Lys Thr Val Lys Tyr Pro Leu 
            20                  25                  30          


Val Ser Pro Val Gln Gly Ala Val Glu Glu Leu Ala Glu Ala Ile Arg 
        35                  40                  45              


His Asp Asn Leu His Leu Phe Gly Gln Lys Glu Ile Val Asp Leu Met 
    50                  55                  60                  


Glu Lys Asp Glu Gly Thr Gln Val Tyr Ser Val Val Asp Phe Trp Leu 
65                  70                  75                  80  


Asp Thr Leu Arg Leu Gly Met Phe Phe Ser Pro Ser Ala Asn Ala Leu 
                85                  90                  95      


Lys Ile Thr Leu Gly Lys Phe Asn Ser Asp Gln Val Ser Pro Phe Arg 
            100                 105                 110         


Lys Val Leu Glu Gln Ser Pro Phe Phe Leu Ala Gly Arg Leu Lys Val 
        115                 120                 125             


Glu Pro Ala Glu Arg Ile Leu Ser Val Glu Ile Arg Lys Ile Gly Lys 
    130                 135                 140                 


Arg Glu Asn Arg Val Glu Asn Tyr Ala Ala Asp Val Glu Thr Cys Phe 
145                 150                 155                 160 


Ile Gly Gln Leu Ser Ser Asp Glu Lys Gln Ser Ile Gln Lys Leu Ala 
                165                 170                 175     


Asn Asp Ile Trp Asp Ser Lys Asp His Glu Glu Gln Arg Met Leu Lys 
            180                 185                 190         


Ala Asp Phe Phe Ala Ile Pro Leu Ile Lys Asp Pro Lys Ala Val Thr 
        195                 200                 205             


Glu Glu Asp Pro Glu Asn Glu Thr Ala Gly Lys Gln Lys Pro Leu Glu 
    210                 215                 220                 


Leu Cys Val Cys Leu Val Pro Glu Leu Tyr Thr Arg Gly Phe Gly Ser 
225                 230                 235                 240 


Ile Ala Asp Phe Leu Val Gln Arg Leu Thr Leu Leu Arg Asp Lys Met 
                245                 250                 255     


Ser Thr Asp Thr Ala Glu Asp Cys Leu Glu Tyr Val Gly Ile Glu Glu 
            260                 265                 270         


Glu Lys Gly Asn Gly Met Asn Ser Leu Leu Gly Thr Phe Leu Lys Asn 
        275                 280                 285             


Leu Gln Gly Asp Gly Phe Glu Gln Ile Phe Gln Phe Met Leu Gly Ser 
    290                 295                 300                 


Tyr Val Gly Trp Gln Gly Lys Glu Asp Val Leu Arg Glu Arg Leu Asp 
305                 310                 315                 320 


Leu Leu Ala Glu Lys Val Lys Arg Leu Pro Lys Pro Lys Phe Ala Gly 
                325                 330                 335     


Glu Trp Ser Gly His Arg Met Phe Leu His Gly Gln Leu Lys Ser Trp 
            340                 345                 350         


Ser Ser Asn Phe Phe Arg Leu Phe Asn Glu Thr Arg Glu Leu Leu Glu 
        355                 360                 365             


Ser Ile Lys Ser Asp Ile Gln His Ala Thr Met Leu Ile Ser Tyr Val 
    370                 375                 380                 


Glu Glu Lys Gly Gly Tyr His Pro Gln Leu Leu Ser Gln Tyr Arg Lys 
385                 390                 395                 400 


Leu Met Glu Gln Leu Pro Ala Leu Arg Thr Lys Val Leu Asp Pro Glu 
                405                 410                 415     


Ile Glu Met Thr His Met Ser Glu Ala Val Arg Ser Tyr Ile Met Ile 
            420                 425                 430         


His Lys Ser Val Ala Gly Phe Leu Pro Asp Leu Leu Glu Ser Leu Asp 
        435                 440                 445             


Arg Asp Lys Asp Arg Glu Phe Leu Leu Ser Ile Phe Pro Arg Ile Pro 
    450                 455                 460                 


Lys Ile Asp Lys Lys Thr Lys Glu Ile Val Ala Trp Glu Leu Pro Gly 
465                 470                 475                 480 


Glu Pro Glu Glu Gly Tyr Leu Phe Thr Ala Asn Asn Leu Phe Arg Asn 
                485                 490                 495     


Phe Leu Glu Asn Pro Lys His Val Pro Arg Phe Met Ala Glu Arg Ile 
            500                 505                 510         


Pro Glu Asp Trp Thr Arg Leu Arg Ser Ala Pro Val Trp Phe Asp Gly 
        515                 520                 525             


Met Val Lys Gln Trp Gln Lys Val Val Asn Gln Leu Val Glu Ser Pro 
    530                 535                 540                 


Gly Ala Leu Tyr Gln Phe Asn Glu Ser Phe Leu Arg Gln Arg Leu Gln 
545                 550                 555                 560 


Ala Met Leu Thr Val Tyr Lys Arg Asp Leu Gln Thr Glu Lys Phe Leu 
                565                 570                 575     


Lys Leu Leu Ala Asp Val Cys Arg Pro Leu Val Asp Phe Phe Gly Leu 
            580                 585                 590         


Gly Gly Asn Asp Ile Ile Phe Lys Ser Cys Gln Asp Pro Arg Lys Gln 
        595                 600                 605             


Trp Gln Thr Val Ile Pro Leu Ser Val Pro Ala Asp Val Tyr Thr Ala 
    610                 615                 620                 


Cys Glu Gly Leu Ala Ile Arg Leu Arg Glu Thr Leu Gly Phe Glu Trp 
625                 630                 635                 640 


Lys Asn Leu Lys Gly His Glu Arg Glu Asp Phe Leu Arg Leu His Gln 
                645                 650                 655     


Leu Leu Gly Asn Leu Leu Phe Trp Ile Arg Asp Ala Lys Leu Val Val 
            660                 665                 670         


Lys Leu Glu Asp Trp Met Asn Asn Pro Cys Val Gln Glu Tyr Val Glu 
        675                 680                 685             


Ala Arg Lys Ala Ile Asp Leu Pro Leu Glu Ile Phe Gly Phe Glu Val 
    690                 695                 700                 


Pro Ile Phe Leu Asn Gly Tyr Leu Phe Ser Glu Leu Arg Gln Leu Glu 
705                 710                 715                 720 


Leu Leu Leu Arg Arg Lys Ser Val Met Thr Ser Tyr Ser Val Lys Thr 
                725                 730                 735     


Thr Gly Ser Pro Asn Arg Leu Phe Gln Leu Val Tyr Leu Pro Leu Asn 
            740                 745                 750         


Pro Ser Asp Pro Glu Lys Lys Asn Ser Asn Asn Phe Gln Glu Arg Leu 
        755                 760                 765             


Asp Thr Pro Thr Gly Leu Ser Arg Arg Phe Leu Asp Leu Thr Leu Asp 
    770                 775                 780                 


Ala Phe Ala Gly Lys Leu Leu Thr Asp Pro Val Thr Gln Glu Leu Lys 
785                 790                 795                 800 


Thr Met Ala Gly Phe Tyr Asp His Leu Phe Gly Phe Lys Leu Pro Cys 
                805                 810                 815     


Lys Leu Ala Ala Met Ser Asn His Pro Gly Ser Ser Ser Lys Met Val 
            820                 825                 830         


Val Leu Ala Lys Pro Lys Lys Gly Val Ala Ser Asn Ile Gly Phe Glu 
        835                 840                 845             


Pro Ile Pro Asp Pro Ala His Pro Val Phe Arg Val Arg Ser Ser Trp 
    850                 855                 860                 


Pro Glu Leu Lys Tyr Leu Glu Gly Leu Leu Tyr Leu Pro Glu Asp Thr 
865                 870                 875                 880 


Pro Leu Thr Ile Glu Leu Ala Glu Thr Ser Val Ser Cys Gln Ser Val 
                885                 890                 895     


Ser Ser Val Ala Phe Asp Leu Lys Asn Leu Thr Thr Ile Leu Gly Arg 
            900                 905                 910         


Val Gly Glu Phe Arg Val Thr Ala Asp Gln Pro Phe Lys Leu Thr Pro 
        915                 920                 925             


Ile Ile Pro Glu Lys Glu Glu Ser Phe Ile Gly Lys Thr Tyr Leu Gly 
    930                 935                 940                 


Leu Asp Ala Gly Glu Arg Ser Gly Val Gly Phe Ala Ile Val Thr Val 
945                 950                 955                 960 


Asp Gly Asp Gly Tyr Glu Val Gln Arg Leu Gly Val His Glu Asp Thr 
                965                 970                 975     


Gln Leu Met Ala Leu Gln Gln Val Ala Ser Lys Ser Leu Lys Glu Pro 
            980                 985                 990         


Val Phe Gln Pro Leu Arg Lys Gly  Thr Phe Arg Gln Gln  Glu Arg Ile 
        995                 1000                 1005             


Arg Lys  Ser Leu Arg Gly Cys  Tyr Trp Asn Phe Tyr  His Ala Leu 
    1010                 1015                 1020             


Met Ile  Lys Tyr Arg Ala Lys  Val Val His Glu Glu  Ser Val Gly 
    1025                 1030                 1035             


Ser Ser  Gly Leu Val Gly Gln  Trp Leu Arg Ala Phe  Gln Lys Asp 
    1040                 1045                 1050             


Leu Lys  Lys Ala Asp Val Leu  Pro Lys Lys Gly Gly  Lys Asn Gly 
    1055                 1060                 1065             


Val Asp  Lys Lys Lys Arg Glu  Ser Ser Ala Gln Asp  Thr Leu Trp 
    1070                 1075                 1080             


Gly Gly  Ala Phe Ser Lys Lys  Glu Glu Gln Gln Ile  Ala Phe Glu 
    1085                 1090                 1095             


Val Gln  Ala Ala Gly Ser Ser  Gln Phe Cys Leu Lys  Cys Gly Trp 
    1100                 1105                 1110             


Trp Phe  Gln Leu Gly Met Arg  Glu Val Asn Arg Val  Gln Glu Ser 
    1115                 1120                 1125             


Gly Val  Val Leu Asp Trp Asn  Arg Ser Ile Val Thr  Phe Leu Ile 
    1130                 1135                 1140             


Glu Ser  Ser Gly Glu Lys Val  Tyr Gly Phe Ser Pro  Gln Gln Leu 
    1145                 1150                 1155             


Glu Lys  Gly Phe Arg Pro Asp  Ile Glu Thr Phe Lys  Lys Met Val 
    1160                 1165                 1170             


Arg Asp  Phe Met Arg Pro Pro  Met Phe Asp Arg Lys  Gly Arg Pro 
    1175                 1180                 1185             


Ala Ala  Ala Tyr Glu Arg Phe  Val Leu Gly Arg Arg  His Arg Arg 
    1190                 1195                 1200             


Tyr Arg  Phe Asp Lys Val Phe  Glu Glu Arg Phe Gly  Arg Ser Ala 
    1205                 1210                 1215             


Leu Phe  Ile Cys Pro Arg Val  Gly Cys Gly Asn Phe  Asp His Ser 
    1220                 1225                 1230             


Ser Glu  Gln Ser Ala Val Val  Leu Ala Leu Ile Gly  Tyr Ile Ala 
    1235                 1240                 1245             


Asp Lys  Glu Gly Met Ser Gly  Lys Lys Leu Val Tyr  Val Arg Leu 
    1250                 1255                 1260             


Ala Glu  Leu Met Ala Glu Trp  Lys Leu Lys Lys Leu  Glu Arg Ser 
    1265                 1270                 1275             


Arg Val  Glu Glu Gln Ser Ser  Ala Gln 
    1280                 1285         


<210> 6
<211> 1192
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY sequence

<400> 6
Met Ala Glu Ser Lys Gln Met Gln Cys Arg Lys Cys Gly Ala Ser Met 
1               5                   10                  15      


Lys Tyr Glu Val Ile Gly Leu Gly Lys Lys Ser Cys Arg Tyr Met Cys 
            20                  25                  30          


Pro Asp Cys Gly Asn His Thr Ser Ala Arg Lys Ile Gln Asn Lys Lys 
        35                  40                  45              


Lys Arg Asp Lys Lys Tyr Gly Ser Ala Ser Lys Ala Gln Ser Gln Arg 
    50                  55                  60                  


Ile Ala Val Ala Gly Ala Leu Tyr Pro Asp Lys Lys Val Gln Thr Ile 
65                  70                  75                  80  


Lys Thr Tyr Lys Tyr Pro Ala Asp Leu Asn Gly Glu Val His Asp Ser 
                85                  90                  95      


Gly Val Ala Glu Lys Ile Ala Gln Ala Ile Gln Glu Asp Glu Ile Gly 
            100                 105                 110         


Leu Leu Gly Pro Ser Ser Glu Tyr Ala Cys Trp Ile Ala Ser Gln Lys 
        115                 120                 125             


Gln Ser Glu Pro Tyr Ser Val Val Asp Phe Trp Phe Asp Ala Val Cys 
    130                 135                 140                 


Ala Gly Gly Val Phe Ala Tyr Ser Gly Ala Arg Leu Leu Ser Thr Val 
145                 150                 155                 160 


Leu Gln Leu Ser Gly Glu Glu Ser Val Leu Arg Ala Ala Leu Ala Ser 
                165                 170                 175     


Ser Pro Phe Val Asp Asp Ile Asn Leu Ala Gln Ala Glu Lys Phe Leu 
            180                 185                 190         


Ala Val Ser Arg Arg Thr Gly Gln Asp Lys Leu Gly Lys Arg Ile Gly 
        195                 200                 205             


Glu Cys Phe Ala Glu Gly Arg Leu Glu Ala Leu Gly Ile Lys Asp Arg 
    210                 215                 220                 


Met Arg Glu Phe Val Gln Ala Ile Asp Val Ala Gln Thr Ala Gly Gln 
225                 230                 235                 240 


Arg Phe Ala Ala Lys Leu Lys Ile Phe Gly Ile Ser Gln Met Pro Glu 
                245                 250                 255     


Ala Lys Gln Trp Asn Asn Asp Ser Gly Leu Thr Val Cys Ile Leu Pro 
            260                 265                 270         


Asp Tyr Tyr Val Pro Glu Glu Asn Arg Ala Asp Gln Leu Val Val Leu 
        275                 280                 285             


Leu Arg Arg Leu Arg Glu Ile Ala Tyr Cys Met Gly Ile Glu Asp Glu 
    290                 295                 300                 


Ala Gly Phe Glu His Leu Gly Ile Asp Pro Gly Ala Leu Ser Asn Phe 
305                 310                 315                 320 


Ser Asn Gly Asn Pro Lys Arg Gly Phe Leu Gly Arg Leu Leu Asn Asn 
                325                 330                 335     


Asp Ile Ile Ala Leu Ala Asn Asn Met Ser Ala Met Thr Pro Tyr Trp 
            340                 345                 350         


Glu Gly Arg Lys Gly Glu Leu Ile Glu Arg Leu Ala Trp Leu Lys His 
        355                 360                 365             


Arg Ala Glu Gly Leu Tyr Leu Lys Glu Pro His Phe Gly Asn Ser Trp 
    370                 375                 380                 


Ala Asp His Arg Ser Arg Ile Phe Ser Arg Ile Ala Gly Trp Leu Ser 
385                 390                 395                 400 


Gly Cys Ala Gly Lys Leu Lys Ile Ala Lys Asp Gln Ile Ser Gly Val 
                405                 410                 415     


Arg Thr Asp Leu Phe Leu Leu Lys Arg Leu Leu Asp Ala Val Pro Gln 
            420                 425                 430         


Ser Ala Pro Ser Pro Asp Phe Ile Ala Ser Ile Ser Ala Leu Asp Arg 
        435                 440                 445             


Phe Leu Glu Ala Ala Glu Ser Ser Gln Asp Pro Ala Glu Gln Val Arg 
    450                 455                 460                 


Ala Leu Tyr Ala Phe His Leu Asn Ala Pro Ala Val Arg Ser Ile Ala 
465                 470                 475                 480 


Asn Lys Ala Val Gln Arg Ser Asp Ser Gln Glu Trp Leu Ile Lys Glu 
                485                 490                 495     


Leu Asp Ala Val Asp His Leu Glu Phe Asn Lys Ala Phe Pro Phe Phe 
            500                 505                 510         


Ser Asp Thr Gly Lys Lys Lys Lys Lys Gly Ala Asn Ser Asn Gly Ala 
        515                 520                 525             


Pro Ser Glu Glu Glu Tyr Thr Glu Thr Glu Ser Ile Gln Gln Pro Glu 
    530                 535                 540                 


Asp Ala Glu Gln Glu Val Asn Gly Gln Glu Gly Asn Gly Ala Ser Lys 
545                 550                 555                 560 


Asn Gln Lys Lys Phe Gln Arg Ile Pro Arg Phe Phe Gly Glu Gly Ser 
                565                 570                 575     


Arg Ser Glu Tyr Arg Ile Leu Thr Glu Ala Pro Gln Tyr Phe Asp Met 
            580                 585                 590         


Phe Cys Asn Asn Met Arg Ala Ile Phe Met Gln Leu Glu Ser Gln Pro 
        595                 600                 605             


Arg Lys Ala Pro Arg Asp Phe Lys Cys Phe Leu Gln Asn Arg Leu Gln 
    610                 615                 620                 


Lys Leu Tyr Lys Gln Thr Phe Leu Asn Ala Arg Ser Asn Lys Cys Arg 
625                 630                 635                 640 


Ala Leu Leu Glu Ser Val Leu Ile Ser Trp Gly Glu Phe Tyr Thr Tyr 
                645                 650                 655     


Gly Ala Asn Glu Lys Lys Phe Arg Leu Arg His Glu Ala Ser Glu Arg 
            660                 665                 670         


Ser Ser Asp Pro Asp Tyr Val Val Gln Gln Ala Leu Glu Ile Ala Arg 
        675                 680                 685             


Arg Leu Phe Leu Phe Gly Phe Glu Trp Arg Asp Cys Ser Ala Gly Glu 
    690                 695                 700                 


Arg Val Asp Leu Val Glu Ile His Lys Lys Ala Ile Ser Phe Leu Leu 
705                 710                 715                 720 


Ala Ile Thr Gln Ala Glu Val Ser Val Gly Ser Tyr Asn Trp Leu Gly 
                725                 730                 735     


Asn Ser Thr Val Ser Arg Tyr Leu Ser Val Ala Gly Thr Asp Thr Leu 
            740                 745                 750         


Tyr Gly Thr Gln Leu Glu Glu Phe Leu Asn Ala Thr Val Leu Ser Gln 
        755                 760                 765             


Met Arg Gly Leu Ala Ile Arg Leu Ser Ser Gln Glu Leu Lys Asp Gly 
    770                 775                 780                 


Phe Asp Val Gln Leu Glu Ser Ser Cys Gln Asp Asn Leu Gln His Leu 
785                 790                 795                 800 


Leu Val Tyr Arg Ala Ser Arg Asp Leu Ala Ala Cys Lys Arg Ala Thr 
                805                 810                 815     


Cys Pro Ala Glu Leu Asp Pro Lys Ile Leu Val Leu Pro Val Gly Ala 
            820                 825                 830         


Phe Ile Ala Ser Val Met Lys Met Ile Glu Arg Gly Asp Glu Pro Leu 
        835                 840                 845             


Ala Gly Ala Tyr Leu Arg His Arg Pro His Ser Phe Gly Trp Gln Ile 
    850                 855                 860                 


Arg Val Arg Gly Val Ala Glu Val Gly Met Asp Gln Gly Thr Ala Leu 
865                 870                 875                 880 


Ala Phe Gln Lys Pro Thr Glu Ser Glu Pro Phe Lys Ile Lys Pro Phe 
                885                 890                 895     


Ser Ala Gln Tyr Gly Pro Val Leu Trp Leu Asn Ser Ser Ser Tyr Ser 
            900                 905                 910         


Gln Ser Gln Tyr Leu Asp Gly Phe Leu Ser Gln Pro Lys Asn Trp Ser 
        915                 920                 925             


Met Arg Val Leu Pro Gln Ala Gly Ser Val Arg Val Glu Gln Arg Val 
    930                 935                 940                 


Ala Leu Ile Trp Asn Leu Gln Ala Gly Lys Met Arg Leu Glu Arg Ser 
945                 950                 955                 960 


Gly Ala Arg Ala Phe Phe Met Pro Val Pro Phe Ser Phe Arg Pro Ser 
                965                 970                 975     


Gly Ser Gly Asp Glu Ala Val Leu Ala Pro Asn Arg Tyr Leu Gly Leu 
            980                 985                 990         


Phe Pro His Ser Gly Gly Ile Glu  Tyr Ala Val Val Asp  Val Leu Asp 
        995                 1000                 1005             


Ser Ala  Gly Phe Lys Ile Leu  Glu Arg Gly Thr Ile  Ala Val Asn 
    1010                 1015                 1020             


Gly Phe  Ser Gln Lys Arg Gly  Glu Arg Gln Glu Glu  Ala His Arg 
    1025                 1030                 1035             


Glu Lys  Gln Arg Arg Gly Ile  Ser Asp Ile Gly Arg  Lys Lys Pro 
    1040                 1045                 1050             


Val Gln  Ala Glu Val Asp Ala  Ala Asn Glu Leu His  Arg Lys Tyr 
    1055                 1060                 1065             


Thr Asp  Val Ala Thr Arg Leu  Gly Cys Arg Ile Val  Val Gln Trp 
    1070                 1075                 1080             


Ala Pro  Gln Pro Lys Pro Gly  Thr Ala Pro Thr Ala  Gln Thr Val 
    1085                 1090                 1095             


Tyr Ala  Arg Ala Val Arg Thr  Glu Ala Pro Arg Ser  Gly Asn Gln 
    1100                 1105                 1110             


Glu Asp  His Ala Arg Met Lys  Ser Ser Trp Gly Tyr  Thr Trp Gly 
    1115                 1120                 1125             


Thr Tyr  Trp Glu Lys Arg Lys  Pro Glu Asp Ile Leu  Gly Ile Ser 
    1130                 1135                 1140             


Thr Gln  Val Tyr Trp Thr Gly  Gly Ile Gly Glu Ser  Cys Pro Ala 
    1145                 1150                 1155             


Val Ala  Val Ala Leu Leu Gly  His Ile Arg Ala Thr  Ser Thr Gln 
    1160                 1165                 1170             


Thr Glu  Trp Glu Lys Glu Glu  Val Val Phe Gly Arg  Leu Lys Lys 
    1175                 1180                 1185             


Phe Phe  Pro Ser 
    1190         


<210> 7
<211> 1192
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY sequence

<400> 7
Met Ala Glu Ser Lys Gln Met Gln Cys Arg Lys Cys Gly Ala Ser Met 
1               5                   10                  15      


Lys Tyr Glu Val Ile Gly Leu Gly Lys Lys Ser Cys Arg Tyr Met Cys 
            20                  25                  30          


Pro Asp Cys Gly Asn His Thr Ser Ala Arg Lys Ile Gln Asn Lys Lys 
        35                  40                  45              


Lys Arg Asp Lys Lys Tyr Gly Ser Ala Ser Lys Ala Gln Ser Gln Arg 
    50                  55                  60                  


Ile Ala Val Ala Gly Ala Leu Tyr Pro Asp Lys Lys Val Gln Thr Ile 
65                  70                  75                  80  


Lys Thr Tyr Lys Tyr Pro Ala Asp Leu Asn Gly Glu Val His Asp Arg 
                85                  90                  95      


Gly Val Ala Glu Lys Ile Glu Gln Ala Ile Gln Glu Asp Glu Ile Gly 
            100                 105                 110         


Leu Leu Gly Pro Ser Ser Glu Tyr Ala Cys Trp Ile Ala Ser Gln Lys 
        115                 120                 125             


Gln Ser Glu Pro Tyr Ser Val Val Asp Phe Trp Phe Asp Ala Val Cys 
    130                 135                 140                 


Ala Gly Gly Val Phe Ala Tyr Ser Gly Ala Arg Leu Leu Ser Thr Val 
145                 150                 155                 160 


Leu Gln Leu Ser Gly Glu Glu Ser Val Leu Arg Ala Ala Leu Ala Ser 
                165                 170                 175     


Ser Pro Phe Val Asp Asp Ile Asn Leu Ala Gln Ala Glu Lys Phe Leu 
            180                 185                 190         


Ala Val Ser Arg Arg Thr Gly Gln Asp Lys Leu Gly Lys Arg Ile Gly 
        195                 200                 205             


Glu Cys Phe Ala Glu Gly Arg Leu Glu Ala Leu Gly Ile Lys Asp Arg 
    210                 215                 220                 


Met Arg Glu Phe Val Gln Ala Ile Asp Val Ala Gln Thr Ala Gly Gln 
225                 230                 235                 240 


Arg Phe Ala Ala Lys Leu Lys Ile Phe Gly Ile Ser Gln Met Pro Glu 
                245                 250                 255     


Ala Lys Gln Trp Asn Asn Asp Ser Gly Leu Thr Val Cys Ile Leu Pro 
            260                 265                 270         


Asp Tyr Tyr Val Pro Glu Glu Asn Arg Ala Asp Gln Leu Val Val Leu 
        275                 280                 285             


Leu Arg Arg Leu Arg Glu Ile Ala Tyr Cys Met Gly Ile Glu Asp Glu 
    290                 295                 300                 


Ala Gly Phe Glu His Leu Gly Ile Asp Pro Gly Ala Leu Ser Asn Phe 
305                 310                 315                 320 


Ser Asn Gly Asn Pro Lys Arg Gly Phe Leu Gly Arg Leu Leu Asn Asn 
                325                 330                 335     


Asp Ile Ile Ala Leu Ala Asn Asn Met Ser Ala Met Thr Pro Tyr Trp 
            340                 345                 350         


Glu Gly Arg Lys Gly Glu Leu Ile Glu Arg Leu Ala Trp Leu Lys His 
        355                 360                 365             


Arg Ala Glu Gly Leu Tyr Leu Lys Glu Pro His Phe Gly Asn Ser Trp 
    370                 375                 380                 


Ala Asp His Arg Ser Arg Ile Phe Ser Arg Ile Ala Gly Trp Leu Ser 
385                 390                 395                 400 


Gly Cys Ala Gly Lys Leu Lys Ile Ala Lys Asp Gln Ile Ser Gly Val 
                405                 410                 415     


Arg Thr Asp Leu Phe Leu Leu Lys Arg Leu Leu Asp Ala Val Pro Gln 
            420                 425                 430         


Ser Ala Pro Ser Pro Asp Phe Ile Ala Ser Ile Ser Ala Leu Asp Arg 
        435                 440                 445             


Phe Leu Glu Ala Ala Glu Ser Ser Gln Asp Pro Ala Glu Gln Val Arg 
    450                 455                 460                 


Ala Leu Tyr Ala Phe His Leu Asn Ala Pro Ala Val Arg Ser Ile Ala 
465                 470                 475                 480 


Asn Lys Ala Val Gln Arg Ser Asp Ser Gln Glu Trp Leu Ile Lys Glu 
                485                 490                 495     


Leu Asp Ala Val Asp His Leu Glu Phe Asn Lys Ala Phe Pro Phe Phe 
            500                 505                 510         


Ser Asp Thr Gly Lys Lys Lys Lys Lys Gly Ala Asn Ser Asn Gly Ala 
        515                 520                 525             


Pro Ser Glu Glu Glu Tyr Thr Glu Thr Glu Ser Ile Gln Gln Pro Glu 
    530                 535                 540                 


Asp Ala Glu Gln Glu Val Asn Gly Gln Glu Gly Asn Gly Ala Ser Lys 
545                 550                 555                 560 


Asn Gln Lys Lys Phe Gln Arg Ile Pro Arg Phe Phe Gly Glu Gly Ser 
                565                 570                 575     


Arg Ser Glu Tyr Arg Ile Leu Thr Glu Ala Pro Gln Tyr Phe Asp Met 
            580                 585                 590         


Phe Cys Asn Asn Met Arg Ala Ile Phe Met Gln Leu Glu Ser Gln Pro 
        595                 600                 605             


Arg Lys Ala Pro Arg Asp Phe Lys Cys Phe Leu Gln Asn Arg Leu Gln 
    610                 615                 620                 


Lys Leu Tyr Lys Gln Thr Phe Leu Asn Ala Arg Ser Asn Lys Cys Arg 
625                 630                 635                 640 


Ala Leu Leu Glu Ser Val Leu Ile Ser Trp Gly Glu Phe Tyr Thr Tyr 
                645                 650                 655     


Gly Ala Asn Glu Lys Lys Phe Arg Leu Arg His Glu Ala Ser Glu Arg 
            660                 665                 670         


Ser Ser Asp Pro Asp Tyr Val Val Gln Gln Ala Leu Glu Ile Ala Arg 
        675                 680                 685             


Arg Leu Phe Leu Phe Gly Phe Glu Trp Arg Asp Cys Ser Ala Gly Glu 
    690                 695                 700                 


Arg Val Asp Leu Val Glu Ile His Lys Lys Ala Ile Ser Phe Leu Leu 
705                 710                 715                 720 


Ala Ile Thr Gln Ala Glu Val Ser Val Gly Ser Tyr Asn Trp Leu Gly 
                725                 730                 735     


Asn Ser Thr Val Ser Arg Tyr Leu Ser Val Ala Gly Thr Asp Thr Leu 
            740                 745                 750         


Tyr Gly Thr Gln Leu Glu Glu Phe Leu Asn Ala Thr Val Leu Ser Gln 
        755                 760                 765             


Met Arg Gly Leu Ala Ile Arg Leu Ser Ser Gln Glu Leu Lys Asp Gly 
    770                 775                 780                 


Phe Asp Val Gln Leu Glu Ser Ser Cys Gln Asp Asn Leu Gln His Leu 
785                 790                 795                 800 


Leu Val Tyr Arg Ala Ser Arg Asp Leu Ala Ala Cys Lys Arg Ala Thr 
                805                 810                 815     


Cys Pro Ala Glu Leu Asp Pro Lys Ile Leu Val Leu Pro Ala Gly Ala 
            820                 825                 830         


Phe Ile Ala Ser Val Met Lys Met Ile Glu Arg Gly Asp Glu Pro Leu 
        835                 840                 845             


Ala Gly Ala Tyr Leu Arg His Arg Pro His Ser Phe Gly Trp Gln Ile 
    850                 855                 860                 


Arg Val Arg Gly Val Ala Glu Val Gly Met Asp Gln Gly Thr Ala Leu 
865                 870                 875                 880 


Ala Phe Gln Lys Pro Thr Glu Ser Glu Pro Phe Lys Ile Lys Pro Phe 
                885                 890                 895     


Ser Ala Gln Tyr Gly Pro Val Leu Trp Leu Asn Ser Ser Ser Tyr Ser 
            900                 905                 910         


Gln Ser Gln Tyr Leu Asp Gly Phe Leu Ser Gln Pro Lys Asn Trp Ser 
        915                 920                 925             


Met Arg Val Leu Pro Gln Ala Gly Ser Val Arg Val Glu Gln Arg Val 
    930                 935                 940                 


Ala Leu Ile Trp Asn Leu Gln Ala Gly Lys Met Arg Leu Glu Arg Ser 
945                 950                 955                 960 


Gly Ala Arg Ala Phe Phe Met Pro Val Pro Phe Ser Phe Arg Pro Ser 
                965                 970                 975     


Gly Ser Gly Asp Glu Ala Val Leu Ala Pro Asn Arg Tyr Leu Gly Leu 
            980                 985                 990         


Phe Pro His Ser Gly Gly Ile Glu  Tyr Ala Val Val Asp  Val Leu Asp 
        995                 1000                 1005             


Ser Ala  Gly Phe Lys Ile Leu  Glu Arg Gly Thr Ile  Ala Val Asn 
    1010                 1015                 1020             


Gly Phe  Ser Gln Lys Arg Gly  Glu Arg Gln Glu Glu  Ala His Arg 
    1025                 1030                 1035             


Glu Lys  Gln Arg Arg Gly Ile  Ser Asp Ile Gly Arg  Lys Lys Pro 
    1040                 1045                 1050             


Val Gln  Ala Glu Val Asp Ala  Ala Asn Glu Leu His  Arg Lys Tyr 
    1055                 1060                 1065             


Thr Asp  Val Ala Thr Arg Leu  Gly Cys Arg Ile Val  Val Gln Trp 
    1070                 1075                 1080             


Ala Pro  Gln Pro Lys Pro Gly  Thr Ala Pro Thr Ala  Gln Thr Val 
    1085                 1090                 1095             


Tyr Ala  Arg Ala Val Arg Thr  Glu Ala Pro Arg Ser  Gly Asn Gln 
    1100                 1105                 1110             


Glu Asp  His Ala Arg Met Lys  Ser Ser Trp Gly Tyr  Thr Trp Ser 
    1115                 1120                 1125             


Thr Tyr  Trp Glu Lys Arg Lys  Pro Glu Asp Ile Leu  Gly Ile Ser 
    1130                 1135                 1140             


Thr Gln  Val Tyr Trp Thr Gly  Gly Ile Gly Glu Ser  Cys Pro Ala 
    1145                 1150                 1155             


Val Ala  Val Ala Leu Leu Gly  His Ile Arg Ala Thr  Ser Thr Gln 
    1160                 1165                 1170             


Thr Glu  Trp Glu Lys Glu Glu  Val Val Phe Gly Arg  Leu Lys Lys 
    1175                 1180                 1185             


Phe Phe  Pro Ser 
    1190         


<210> 8
<211> 1193
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY Ortholog  sequence

<400> 8
Met Lys Arg Ile Ala Lys Phe Arg His Asp Lys Pro Val Lys Arg Glu 
1               5                   10                  15      


Ala Trp Ser Lys Gly Tyr Arg Val His Lys Asn Arg Ile Ile Asn Lys 
            20                  25                  30          


Val Thr Arg Ser Ile Lys Tyr Pro Leu Val Val Lys Asp Glu Trp Lys 
        35                  40                  45              


Lys Arg Leu Ile Asp Asp Ala Ala His Asp Tyr Arg Trp Leu Val Gly 
    50                  55                  60                  


Pro Ile Asn Tyr Ser Asp Trp Cys Arg Asp Pro Asn Gln Tyr Ser Ile 
65                  70                  75                  80  


Leu Glu Phe Trp Ile Asp Phe Leu Cys Val Gly Gly Val Phe Gln Ser 
                85                  90                  95      


Ser His Ser Asn Ile Cys Arg Leu Ala Ile Gln Leu Ser Gly Gly Ser 
            100                 105                 110         


Val Phe Glu Gln Glu Trp Lys Asp Leu Ser Pro Phe Val Arg Ala Asn 
        115                 120                 125             


Leu Ile Gln Gly Ile Lys Pro Ala Glu Phe Ile Gly Phe Leu Thr Ala 
    130                 135                 140                 


Glu Phe Arg Ser Ser Ser Asn Pro Lys Asn Phe Ile Ser Lys Phe Phe 
145                 150                 155                 160 


Glu Gly Ser Asn Glu Asp Leu Glu Ser Leu Thr Asn Glu Phe Ala Ser 
                165                 170                 175     


Ile Val Asp Phe Ile Lys Ala Lys Asp Ile Ser Leu Leu Arg Lys Ser 
            180                 185                 190         


Leu Pro Ser Cys Lys Lys Ile Ala Pro Asn Leu Trp Glu Lys Ala Val 
        195                 200                 205             


Gly Ser His Ser Thr Asn Glu Leu Leu Lys Leu Leu Thr Lys Tyr Thr 
    210                 215                 220                 


Arg Val Met Leu Val Ala Glu Pro Ser His Ser Asp Arg Val Phe Ser 
225                 230                 235                 240 


Gln Thr Val Leu Gln Ser Asn Asp Gln Asp Asp Pro Glu Leu Thr Gly 
                245                 250                 255     


Pro Leu Pro Ser His Lys Val Gly Lys Ala Ser Tyr Leu Phe Ile Pro 
            260                 265                 270         


Glu Phe Ile Arg Glu Val Asn Leu Asp Lys Ile Ser Lys Leu Asp Leu 
        275                 280                 285             


Ser Ala Lys Ser Lys Leu Ala Val Glu Gln Val Lys Lys Leu Ser Glu 
    290                 295                 300                 


Leu Thr Ser Asp Phe Lys Gln Ile Glu Asn Gln Ser Glu Ala Tyr Phe 
305                 310                 315                 320 


Gly Leu Ser Thr Ser Phe Asn Glu Leu Ser Asn Phe Leu Gly Ile Leu 
                325                 330                 335     


Ile Arg Thr Leu Arg Asn Ala Pro Glu Ala Ile Leu Lys Asp Gln Ile 
            340                 345                 350         


Ala Leu Cys Ala Pro Leu Asp Lys Asp Ile Leu Lys Ile Thr Leu Asp 
        355                 360                 365             


Trp Leu Cys Asp Arg Ala Gln Ala Leu Pro Glu Asn Pro Arg Phe Glu 
    370                 375                 380                 


Thr Asn Trp Ala Glu Tyr Arg Ser Tyr Leu Gly Gly Lys Ile Lys Ser 
385                 390                 395                 400 


Trp Phe Ser Asn Tyr Glu Asn Phe Phe Glu Ile Pro Gln Ala Ala Ser 
                405                 410                 415     


Ser Gln Gln Asn Asn Asn Arg Glu Lys Lys Leu Gly Asn Arg Ser Ala 
            420                 425                 430         


Ile Arg Ala Leu Asn Leu Lys Lys Glu Ala Phe Glu Lys Ala Arg Glu 
        435                 440                 445             


Thr Phe Lys Gly Asp Lys Gly Thr Leu Glu Lys Ile Asp Leu Ala Tyr 
    450                 455                 460                 


Arg Leu Leu Gly Ser Ile Ser Pro Glu Val Leu Gln Cys Asp Glu Gly 
465                 470                 475                 480 


Leu Lys Leu Tyr Gln Gln Phe Asn Asp Glu Leu Leu Val Leu Asn Glu 
                485                 490                 495     


Thr Ile Asn Gln Lys Phe Gln Asp Ala Lys Arg Asp Ile Lys Ala Lys 
            500                 505                 510         


Lys Glu Lys Glu Ser Phe Glu Lys Leu Gln Arg Asn Leu Ser Ser Pro 
        515                 520                 525             


Leu Pro Arg Ile Pro Glu Phe Phe Gly Glu Arg Ala Lys Lys Gly Tyr 
    530                 535                 540                 


Gln Lys Ala Arg Val Ser Pro Lys Leu Ala Arg His Leu Leu Glu Cys 
545                 550                 555                 560 


Leu Asn Asp Trp Leu Ala Arg Phe Ala Lys Val Glu Glu Ser Ala Phe 
                565                 570                 575     


Ser Glu Lys Glu Phe Gln Arg Ile Leu Asp Trp Leu Arg Thr Ser Asp 
            580                 585                 590         


Phe Leu Pro Val Phe Ile Arg Lys Ser Lys Asp Pro Pro Ser Trp Leu 
        595                 600                 605             


Arg Tyr Ile Ala Arg Val Ala Thr Gly Lys Tyr Tyr Phe Trp Val Ser 
    610                 615                 620                 


Glu Tyr Ser Arg Lys Arg Val Gln Ile Ile Asp Lys Pro Ile Ala Gln 
625                 630                 635                 640 


Asn Pro Leu Lys Glu Leu Ile Ser Trp Phe Leu Leu Asn Lys Asp Ala 
                645                 650                 655     


Phe Ser Arg Asp Asn Glu Leu Phe Lys Gly Leu Ser Ser Lys Met Val 
            660                 665                 670         


Thr Leu Ala Arg Ile Met Ala Gly Ile Leu Arg Asp Arg Gly Glu Gly 
        675                 680                 685             


Leu Lys Glu Leu Gln Ala Met Thr Ser Lys Leu Asp Asn Ile Gly Leu 
    690                 695                 700                 


Leu His Pro Ser Phe Ser Val Pro Val Thr Asp Ser Leu Lys Asp Ala 
705                 710                 715                 720 


Ala Phe Tyr Arg Ala Phe Phe Ser Glu Leu Glu Gly Leu Leu Asn Ile 
                725                 730                 735     


Gly Arg Ser Arg Leu Ile Ile Glu Arg Ile Thr Leu Gln Ser Gln Gln 
            740                 745                 750         


Ser Lys Asn Lys Lys Thr Arg Arg Pro Leu Met Pro Glu Pro Phe Ile 
        755                 760                 765             


Asn Glu Asp Lys Glu Val Phe Leu Ala Phe Pro Lys Phe Glu Thr Lys 
    770                 775                 780                 


Asn Lys Val Lys Gly Thr Arg Val Val Tyr Asn Ser Pro Asp Glu Val 
785                 790                 795                 800 


Asn Trp Leu Leu Ser Pro Ile Arg Ser Ser Lys Gly Gln Leu Ser Phe 
                805                 810                 815     


Met Phe Arg Cys Leu Ser Glu Asp Ala Lys Ile Met Thr Thr Ser Gly 
            820                 825                 830         


Gly Cys Ser Tyr Ile Val Glu Phe Lys Lys Leu Leu Glu Ala Gln Glu 
        835                 840                 845             


Glu Val Leu Ser Ile His Asp Cys Asp Ile Ile Pro Arg Ala Phe Val 
    850                 855                 860                 


Ser Ile Pro Phe Thr Leu Glu Arg Glu Ser Glu Glu Thr Lys Pro Asp 
865                 870                 875                 880 


Trp Lys Pro Asn Arg Phe Met Gly Val Asp Ile Gly Glu Tyr Ala Val 
                885                 890                 895     


Ala Tyr Cys Val Ile Glu Lys Gly Thr Asp Ser Ile Glu Ile Leu Asp 
            900                 905                 910         


Cys Gly Ile Val Arg Asn Gly Ala His Arg Val Leu Lys Glu Lys Val 
        915                 920                 925             


Asp Arg Leu Lys Arg Arg Gln Arg Ser Met Thr Phe Gly Ala Met Asp 
    930                 935                 940                 


Thr Ser Ile Ala Ala Ala Arg Glu Ser Leu Val Gly Asn Tyr Arg Asn 
945                 950                 955                 960 


Arg Leu His Ala Ile Ala Leu Lys His Gly Ala Lys Leu Val Tyr Glu 
                965                 970                 975     


Tyr Glu Val Ser Ala Phe Glu Ser Gly Gly Asn Arg Ile Lys Lys Val 
            980                 985                 990         


Tyr Glu Thr Leu Lys Lys Ser Asp  Cys Thr Gly Glu Thr  Glu Ala Asp 
        995                 1000                 1005             


Lys Asn  Ala Arg Lys His Ile  Trp Gly Glu Thr Asn  Ala Val Gly 
    1010                 1015                 1020             


Asp Gln  Ile Gly Ala Gly Trp  Thr Ser Gln Thr Cys  Ala Lys Cys 
    1025                 1030                 1035             


Gly Arg  Ser Phe Gly Ala Asp  Leu Lys Ala Gly Asn  Phe Gly Val 
    1040                 1045                 1050             


Ala Val  Pro Val Pro Glu Lys  Val Glu Asp Ser Lys  Gly His Tyr 
    1055                 1060                 1065             


Ala Tyr  His Glu Phe Pro Phe  Glu Asp Gly Leu Lys  Val Arg Gly 
    1070                 1075                 1080             


Phe Leu  Lys Pro Asn Lys Ile  Ile Ser Asp Gln Lys  Glu Leu Ala 
    1085                 1090                 1095             


Lys Ala  Val His Ala Tyr Met  Arg Pro Pro Leu Val  Ala Leu Gly 
    1100                 1105                 1110             


Lys Arg  Lys Leu Pro Lys Asn  Ala Arg Tyr Arg Arg  Gly Asn Ser 
    1115                 1120                 1125             


Ser Leu  Phe Arg Cys Pro Phe  Ser Asp Cys Gly Phe  Thr Ala Asp 
    1130                 1135                 1140             


Ala Asp  Ile Gln Ala Ala Tyr  Asn Ile Ala Val Lys  Gln Leu Tyr 
    1145                 1150                 1155             


Lys Pro  Lys Lys Gly Tyr Pro  Lys Glu Arg Lys Trp  Gln Asp Phe 
    1160                 1165                 1170             


Val Ile  Leu Lys Pro Lys Glu  Pro Ser Lys Leu Phe  Asp Lys Gln 
    1175                 1180                 1185             


Phe Tyr  Arg Pro Asn 
    1190             


<210> 9
<211> 1154
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY10 sequence

<400> 9
Met Lys Asp Ser Lys Ile Asn Ala Pro Ile Asn Ile Asn Ala Asn Asn 
1               5                   10                  15      


Val Ser Lys Asn Lys Thr Pro Lys Lys Lys Pro Arg Arg Lys Ser Gly 
            20                  25                  30          


Lys Arg Gly Tyr Arg Leu His Asp Glu Arg Ile Ala Tyr Ser Gly Gly 
        35                  40                  45              


Thr Gly Ser Cys Arg Ser Ile Lys Tyr Glu Leu Leu Asn Pro Asp Ala 
    50                  55                  60                  


Thr Arg Lys Asn Leu Leu Arg Gly Ser Gly Leu Gln His Glu Ile Ile 
65                  70                  75                  80  


Ser Ala Val Arg Gln Asp Asn Leu Leu Leu Tyr Gly Pro Leu Asn Phe 
                85                  90                  95      


Asn Asp Tyr Ile Phe Asp Lys Asp Ala Pro Asn Leu Leu His Phe Trp 
            100                 105                 110         


Thr Leu Ala Leu Ser Leu Gly Phe Val Phe Ser Asn Gln Asn Ser Ile 
        115                 120                 125             


Glu Arg Glu Phe Lys Asp Tyr Leu Gly Val Ser Thr Glu Glu Ala Val 
    130                 135                 140                 


Leu Phe Gly Lys Leu Asn Glu Thr Leu Lys Ala Val Phe Asp Glu Ala 
145                 150                 155                 160 


Lys Phe Ile Ser Gly Phe Leu Tyr Arg Asn Phe Arg Gly Leu Ala Ser 
                165                 170                 175     


Lys Thr Arg Glu Gln Arg Ile Lys Leu Leu Thr Asp Thr Leu Arg Glu 
            180                 185                 190         


Pro Leu Asp Gly Val Asn Gly Asp Ser Val Ser Glu Ile Ile Lys Pro 
        195                 200                 205             


Tyr Ala Glu Lys Trp Ala Glu Tyr Asp Gly Glu Cys Asp Gln Phe Val 
    210                 215                 220                 


Phe Lys Cys Glu Leu Phe Ser Ile Lys Ser Thr Asp Lys Pro Arg Glu 
225                 230                 235                 240 


Asn Thr Arg Leu Ser Phe Ala Ile Asp Pro Ala Phe Glu Val Met Lys 
                245                 250                 255     


Leu Asp Asp Lys Thr Val Phe Phe Asp Asp Leu Ile Thr His Tyr Lys 
            260                 265                 270         


Glu Asn Cys Ser Asp Glu Ala Gln Ala Lys Arg Phe Leu Gly Ile Gly 
        275                 280                 285             


Asp Asn Gly Asn Tyr Phe Asn Gly Ile Phe Gly Gly Leu Phe Glu Leu 
    290                 295                 300                 


Leu Thr Asp Gly Asp Glu Lys Ile Cys Glu Thr Thr Asp His Leu Ala 
305                 310                 315                 320 


Arg Ile Tyr Gly Phe Asp Glu Thr Lys Lys Thr Glu Ile Asn Lys Arg 
                325                 330                 335     


Leu Val Arg Leu Ala Glu Tyr Ala Arg Gln Ile Asn Arg Arg Pro Cys 
            340                 345                 350         


Leu Val Lys Arg Trp Ser Glu Tyr Arg Ser Asp Phe Asn Gly Thr Ile 
        355                 360                 365             


Glu Ser Trp Tyr Ser Asn Arg Gln Ser Lys Gln Asn Asp Thr Leu Lys 
    370                 375                 380                 


Gln Leu Asp Glu Lys Leu Lys Leu Leu Glu Glu Met Arg Ala Ser Phe 
385                 390                 395                 400 


Pro Thr Asp Ser Asp Leu Cys Gly Ile Lys Ser Leu Ser Glu Thr Ile 
                405                 410                 415     


Glu Phe Ile Arg Ser Leu Lys Gly Glu Arg Ile Ala Arg Lys Val Thr 
            420                 425                 430         


Asp Glu Leu Glu Ser Tyr Leu Ala Val Leu Gly Ser Glu Leu Asn Gln 
        435                 440                 445             


Tyr Thr Gln Gln Asn Lys Asp His Ala Leu Pro Leu Gly Trp Gln Lys 
    450                 455                 460                 


Lys Leu Ser Lys His Ile Gln Ser Ser Pro Leu Phe Phe Gly Glu Asn 
465                 470                 475                 480 


Lys Ile Ala Leu Trp Glu Lys Leu Ile Asn Leu Lys Glu Leu Ile Lys 
                485                 490                 495     


Thr Glu Val Lys Glu Leu Glu Val Val Leu Ala Glu Asp Phe Asp Asp 
            500                 505                 510         


Tyr Glu Ile Thr Asp Lys Gln Val Asp Asn Leu Ala Ala Leu Ala Gly 
        515                 520                 525             


Arg Phe Ser Glu Ser Pro Asp Gly Ser Gly His Pro Leu Val Thr Glu 
    530                 535                 540                 


Arg Leu Ala Lys Ile Glu Ser Thr Leu Gly Val Asp Phe Thr His Lys 
545                 550                 555                 560 


Asn Asn Arg Ala Lys Phe Tyr Leu Ser Gly Phe Glu Arg Gly Lys Phe 
                565                 570                 575     


Gly Lys Leu Asp Val Pro Asn Lys Ile Lys Val Ser His Leu Phe Glu 
            580                 585                 590         


Leu Ala Asp Leu Ser Ile Leu Tyr Asn Ala Val Ala Asn Ser Pro Glu 
        595                 600                 605             


Asp Gly Tyr Ile Leu Arg Asp Thr Ala Gln Leu Ser Lys Ile Ile Leu 
    610                 615                 620                 


Ser Ala Lys Leu Arg Asp Ala Asp Arg Glu Lys Gln Arg Lys Thr Val 
625                 630                 635                 640 


Leu Ala His Ser Thr Leu Gln Gly Tyr Ser Ala Leu Ile Ser Lys Arg 
                645                 650                 655     


Glu Phe Val Ser Arg Tyr Pro Leu Gln Ala Val Asn Gly Ser Gln Asn 
            660                 665                 670         


Leu Met Ala Tyr Asp Ala Asn Arg Lys Tyr Tyr Tyr Ala Tyr Asn Ser 
        675                 680                 685             


Glu Lys Phe Ala Gly Thr Lys Glu Leu Thr Val Ala Leu Arg Gly Asn 
    690                 695                 700                 


Asn Phe Gly Pro Glu Ala Phe Gly Gly Lys Phe Lys Lys Val Pro Ala 
705                 710                 715                 720 


Leu Arg Val Gln Ser Ser Lys Tyr Gln Ile Gln Phe Leu Asp Trp Phe 
                725                 730                 735     


Phe Glu Lys Gln Lys Lys Arg Lys Thr Glu Leu Gly Ala Gly Gly Ser 
            740                 745                 750         


Phe Thr Ile Ala Glu Ile Ser Cys Lys Val Asn Trp Asp Asp Lys Thr 
        755                 760                 765             


Pro Val Ile Phe Glu Lys Pro Asp Pro Arg Leu Phe Val Ser Gln Pro 
    770                 775                 780                 


Phe Thr Ile Asn Pro Pro Glu Asn Ser Ala Lys Lys Asp Tyr Ala Arg 
785                 790                 795                 800 


Tyr Ile Gly Ile Asp Ile Gly Glu Tyr Gly Leu Ala Trp His Leu Val 
                805                 810                 815     


Glu Val Phe Glu Asp Ala Asn Glu Asp Ile Gly Gly Ala Gly Lys Asn 
            820                 825                 830         


Ala Val Arg Ile Lys Ser Val Glu Lys Gly Phe Phe Thr Asp Pro Gln 
        835                 840                 845             


Gln Ile Ser Leu Lys Glu Asp Val Lys Lys Leu Arg Glu Asn Gln Val 
    850                 855                 860                 


Arg Ala Thr Phe Thr Ser Pro Asp Thr Lys Ile Ala Arg Val Arg Glu 
865                 870                 875                 880 


Ser Leu Ile Gly Ser Tyr Arg Asn Leu Leu Glu Asp Leu Ala Val Arg 
                885                 890                 895     


Lys Asp Ala Arg Leu Cys Phe Glu Tyr Glu Val Ser Gly Phe Glu Ser 
            900                 905                 910         


Gly Gly Ala Arg Ile Ser Lys Val Tyr Asp Ser Ile Lys Arg Ser Ser 
        915                 920                 925             


Val Ala Lys Lys Glu Asn Lys Ala Glu Asn Lys Gln Ser Trp Gly Lys 
    930                 935                 940                 


Leu Phe Gly Pro Glu Phe Ser Phe Lys Ala Ile Glu Ile Thr Ala Ala 
945                 950                 955                 960 


Gly Thr Ser Gln Tyr Cys Thr Lys Cys Lys Arg Trp Ala Ser Leu Ala 
                965                 970                 975     


Ile Lys Asp Asn Asn Asn Tyr Gln Leu Leu Glu Trp Asp Asn Gly Glu 
            980                 985                 990         


Thr Gly Asp Lys Arg Gly Ser Asp  Gly Leu Leu Ala Val  Thr Leu Asp 
        995                 1000                 1005             


Gly Glu  Gly Lys Glu Thr Asn  Arg Thr Val Arg Leu  Phe Pro Lys 
    1010                 1015                 1020             


Asp Gly  Lys Lys Ala Gly Asp  Thr Ile Lys Gly Lys  Asp Leu Lys 
    1025                 1030                 1035             


Ser Ala  Ile Tyr Arg Ala Met  Arg Pro Asn Met Arg  Pro Ser Glu 
    1040                 1045                 1050             


Asp Gly  Ser Ile Ser Leu Gly  Ala Gly Met Glu Ala  Val Arg Arg 
    1055                 1060                 1065             


Asp Leu  Met Pro Glu Gln Trp  Glu Lys Leu Thr Leu  Glu Phe Gly 
    1070                 1075                 1080             


Gln Gly  Lys Pro Arg Gly Asn  Met Ala Ile Tyr Val  Cys Pro Tyr 
    1085                 1090                 1095             


Cys Gly  His Ile Ser Asp Ala  Asp Met Gln Ala Ala  Phe Asn Ile 
    1100                 1105                 1110             


Ala Val  Arg Gly Tyr Leu Ala  Asn Arg Asp Lys Glu  Lys Lys Val 
    1115                 1120                 1125             


Lys Leu  Gly Lys Glu Tyr Leu  Thr Asp Glu Gln Ser  Lys Leu Thr 
    1130                 1135                 1140             


Phe Asp  Pro Val Gly Ile Leu  Glu His Thr Thr 
    1145                 1150                 


<210> 10
<211> 1266
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasY15 sequence

<400> 10
Met Pro Leu Met Ile Arg Asn Thr Met Asn Glu Lys Lys Thr Ala Thr 
1               5                   10                  15      


Gln Arg Arg Asn Ala Arg Arg Arg Arg Gly Glu Arg Ala Arg Thr Lys 
            20                  25                  30          


Ser Gln Glu Leu Arg Gly Tyr Arg Leu His Asp Ala Arg Ile Glu Phe 
        35                  40                  45              


Ser Gly Gly Leu Gly Ser Met Arg Thr Val Lys Val Glu Leu Leu Asn 
    50                  55                  60                  


Pro Asp Ser Ser Arg Glu Asp Pro Gln Arg Gly Gln Gly Leu Gln Gly 
65                  70                  75                  80  


Lys Val Ala Lys Ala Val Phe Asp Asp Tyr Arg Ala Leu Tyr Gly Pro 
                85                  90                  95      


Met Asn Ile Glu Asp Tyr Leu Ser Asp Pro Asp Cys Pro Ser Phe Leu 
            100                 105                 110         


Gly Leu Trp Val Lys Ala Val Cys Leu Gly Val Ile Met Ser Arg Lys 
        115                 120                 125             


Thr Ala Thr Asp Phe Gly Glu Leu Arg Gly Gly Ser Lys Ser Gly Gln 
    130                 135                 140                 


Ala Phe Asp Ser Ile Pro Glu His Leu Arg Arg Gln Leu Ile Lys Leu 
145                 150                 155                 160 


Lys Trp Leu Asp Trp Tyr Asp Lys Gly Ile Arg Lys Ser Ser Ser Lys 
                165                 170                 175     


Ala Ser Arg Leu Lys Ser Leu Thr Asp Val Phe Ala Asn Pro Lys Gln 
            180                 185                 190         


Pro Asp Gln Gly Val Met Ala Ala Trp Glu Gln Gly Glu Lys Leu Ala 
        195                 200                 205             


Glu Ser Ser Arg Asp Ile Ala Ala Leu Gly Arg Arg Glu Phe Lys Asp 
    210                 215                 220                 


Lys Leu Phe Ala Ile Pro Pro Pro Thr Ser Ser Val Val Leu Asp Asp 
225                 230                 235                 240 


Asp Val Lys Ala Thr Lys Val Ser Arg Asp Trp Gln Trp Ala Val Asp 
                245                 250                 255     


Pro Gln Phe Lys Leu Pro Ser Thr Asp Leu Asp Ile Thr Arg Ala Leu 
            260                 265                 270         


Glu Glu Val Asp Arg Gln Trp Phe Glu Arg Leu Gly Asn Asn Arg Gly 
        275                 280                 285             


Met Val Gln Gln Phe Phe Ala Ile Gly Asp Asn Gly Asn His Leu Asn 
    290                 295                 300                 


Asn Gly Leu Phe Gly His Phe Phe Ala Ser Ile Arg Ser Ala Asn Leu 
305                 310                 315                 320 


Ala Asp Ile Val Ala Glu Met Gly Thr Ala Phe Gly Phe Ser Ala Glu 
                325                 330                 335     


Glu Arg Asp Ile Val Arg Gln Arg Leu Glu Thr Leu His Glu Tyr Ala 
            340                 345                 350         


Gln Gly Leu Pro Glu Lys Pro Val Leu Ala Ser Arg Trp Ala Glu Tyr 
        355                 360                 365             


Arg Thr Asp Met Thr Ala Lys Leu Gly Ser Trp Tyr Ser Asn Arg Thr 
    370                 375                 380                 


Ser Lys Gly Ala Ala Ser Ile Thr Gln Val Trp Gly Thr Ile Asn Thr 
385                 390                 395                 400 


Glu Thr Gly Glu Val Lys Asp Asp Gly Leu Val Arg Thr Leu Glu Asn 
                405                 410                 415     


Ile Gln Ser Asp Leu Pro Asp Ser Cys Ser Ile Lys Glu Gly Ile Leu 
            420                 425                 430         


Gln Glu Thr Leu Asp Phe Ile Gly Asp Arg Arg Ser Ser Thr Asp Arg 
        435                 440                 445             


Ala Phe Thr Asp Glu Leu Glu Leu Tyr Leu Ala Thr Leu Arg Ser Asp 
    450                 455                 460                 


Leu Asn Thr Trp Cys Gln Glu Gln Ser Ala Leu Trp Glu Glu Lys Gln 
465                 470                 475                 480 


Arg Gln Val Ala Thr Pro Ala Ser Asp Glu Lys Ser Lys Lys Ala Asp 
                485                 490                 495     


Asn Pro Trp Ala Gly Lys Gly Ser Lys Thr Asp Lys Trp Leu Gly Ala 
            500                 505                 510         


Leu His Thr Arg Ile Gln Ser Ser Pro Leu Phe Trp Gly Val Asp Lys 
        515                 520                 525             


Leu Glu Leu Trp Lys Thr Leu Ala Asn Leu Lys Gln Ala Ile Arg Asp 
    530                 535                 540                 


Glu Ile Asp Lys Leu Asn Glu Gln Val Glu Val Phe Gly Arg Ser Ala 
545                 550                 555                 560 


Tyr Asp Glu Pro Val Gly Lys Asp Ala Asp Ser Gly Glu Gly Asp Arg 
                565                 570                 575     


Arg Val Asp Gln Leu Ser Tyr Leu Ser Ala Arg Leu Gly Asp Gln Ala 
            580                 585                 590         


His Glu Glu Val Arg Gln Arg Leu Asp Ala Ile Ala Leu Ala Leu Gly 
        595                 600                 605             


Val Lys Phe Ser Glu Arg Asp Asp Leu His Arg Phe Phe Val Ser Ser 
    610                 615                 620                 


Arg Ala Arg Arg Arg Ala Ala Leu Leu Ala Met Pro Asn Thr Ile Thr 
625                 630                 635                 640 


Val Gly Lys Leu Arg Glu Leu Ala Asp Leu Thr Pro Leu Trp Glu Arg 
                645                 650                 655     


Ile Lys Lys Lys Pro Glu Glu Pro Arg Leu Leu Ala Asp Thr Val Ala 
            660                 665                 670         


Leu Ser Lys Val Val Asn Ser Ala Cys Ala Ser Arg Ala Asn Pro Ser 
        675                 680                 685             


Asp Gln Ile Glu Leu Thr Thr Ile His Ser Arg Leu Asp Gly Tyr Ser 
    690                 695                 700                 


Lys Asn Ile Gly His Thr Glu Phe Ile Ser Arg Ala Thr Val Gln Ser 
705                 710                 715                 720 


Thr Asn Gly Ala Gln Asn Thr Val Ala Leu Asp Ser Leu Val Ser Pro 
                725                 730                 735     


Arg Leu Phe Tyr Tyr Asn Phe Pro Asn Ile Val Glu Ser Ala Glu Pro 
            740                 745                 750         


His Val Ser His Leu Glu Val Ala Thr Arg Gly Asn Leu Gly Ser Phe 
        755                 760                 765             


Glu Glu Phe Ala Ala Lys Glu His Arg Thr Phe Asp Arg Glu Asn Pro 
    770                 775                 780                 


Gln Lys Asp Ser Arg Asn Arg Ile Asp Ser Val Asn Pro Leu Ala Val 
785                 790                 795                 800 


Ala Ser Ser Arg Tyr Gln Ile Gln Phe Phe Thr Trp Trp Ala Gly Leu 
                805                 810                 815     


His Arg Ser Lys Glu Thr Ala Leu Glu Val Gly Gly Ser Phe Thr Ile 
            820                 825                 830         


Ala Glu Arg Gln Val Arg Leu Asp Trp Ser Gln Glu Lys Pro Gln Ala 
        835                 840                 845             


Val Val Ser Glu Glu Leu Arg Val Phe Val Ser Gln Pro Phe Thr Ile 
    850                 855                 860                 


Val Pro Asp Asp Lys Lys Arg Pro Ala Thr Ser Gly Thr Arg Tyr Ile 
865                 870                 875                 880 


Gly Val Ala Ile Gly Glu Tyr Gly Leu Ala Trp Ser Cys Trp Glu Phe 
                885                 890                 895     


Ala Pro Gly Tyr Trp Asn Gly Ser Val Val Asn Pro Ser Lys Val Thr 
            900                 905                 910         


Cys Leu Asp Tyr Gly Phe Leu Ala Glu Pro Gly Gln Arg Arg Ile Val 
        915                 920                 925             


Glu Arg Val Lys Lys Leu Arg Glu Ser Gln Ala Thr Lys Thr Phe Thr 
    930                 935                 940                 


Ser Pro Asp Thr Tyr Ile Ala Arg Leu Arg Glu Asn Val Val Ala Thr 
945                 950                 955                 960 


Tyr Gln Ala Gln Leu Glu Ala Leu Met Met Ala Tyr Asn Ala Gln Leu 
                965                 970                 975     


Val Phe Ala Ser Glu Ile Ser Ala Phe Glu Thr Gly Gly Asn Arg Val 
            980                 985                 990         


Lys Lys Ile Tyr Asp Ala Ile Lys  Arg Ser Ser Val Phe  Gly Arg Ser 
        995                 1000                 1005             


Asp Ala  Glu Ala Thr Asp Asn  Asn Gln His Trp Gly  Lys Asn Gly 
    1010                 1015                 1020             


Asn Arg  Ser Ser Val Lys Asp  Pro Asp Lys Leu Arg  Leu Asn Glu 
    1025                 1030                 1035             


Ala Gly  Gln Val Ala Ala Arg  Val Pro Trp Ala Glu  Pro Val Ser 
    1040                 1045                 1050             


Ala Trp  Met Thr Ser Gln Thr  Cys Ser Ala Cys Gly  Arg Val Tyr 
    1055                 1060                 1065             


Val Arg  Ala Tyr Arg Gly Lys  Asn Ser Asn Glu Pro  Asp Ser Gly 
    1070                 1075                 1080             


Ala Thr  Gly Glu Val Arg Tyr  Phe Asp Asn Lys Gln  Gln Lys Ile 
    1085                 1090                 1095             


Leu Thr  Lys Thr Ile Gly Ala  Asp Thr Val Trp Val  Thr Asp Gln 
    1100                 1105                 1110             


Glu Arg  Lys Glu Phe Glu Arg  Gly Val Tyr Asn Ala  Met Arg Pro 
    1115                 1120                 1125             


Asn Ala  Phe Met Pro Asp Gly  Arg Trp Thr Ala Ala  Gly Glu Ile 
    1130                 1135                 1140             


Leu Glu  Ala Ala Leu Lys Ser  Arg Gly Thr Leu Asp  Gly Gly Arg 
    1145                 1150                 1155             


Gly Phe  Ala Gly Leu His Leu  Thr Ser Lys Ala Gln  Val His Glu 
    1160                 1165                 1170             


Tyr Ile  Glu Gly Thr Gly Lys  Ser His Ala Asp Ala  His Gly Asn 
    1175                 1180                 1185             


Ser Ala  Ile Phe Ile Cys Pro  Tyr Thr Asp Cys Gly  His Ile Ala 
    1190                 1195                 1200             


Asp Ala  Ala Leu Gln Ala Ser  Tyr Asn Ile Ala Leu  Arg Gly Phe 
    1205                 1210                 1215             


Ala Tyr  Ala Ile Val Arg Lys  Lys His Pro Glu Leu  Phe Ala Gly 
    1220                 1225                 1230             


Ser Gly  Ser Ser Thr Asp Gly  Asp Glu Gly Gly Gly  Lys Lys Pro 
    1235                 1240                 1245             


Gln Gln  Lys Gln Ala Phe Ile  Asp Glu Ile Val Arg  Ala Ala Gly 
    1250                 1255                 1260             


Arg Ala  Ser 
    1265     


<210> 11
<211> 5
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
uuuuu                                                                    5


<210> 12
<211> 8
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
uuuuuuuu                                                                 8


<210> 13
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
uuuuuuuuuu                                                              10


<210> 14
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 14
ttttuutttt                                                              10


<210> 15
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 15
ttuutt                                                                   6


<210> 16
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 16
taaugc                                                                   6


<210> 17
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 17
tauggc                                                                   6


<210> 18
<211> 5
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
uuuuu                                                                    5


<210> 19
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ttattatt                                                                 8


<210> 20
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
tttttt                                                                   6


<210> 21
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
tttttttt                                                                 8


<210> 22
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
tttttttttt                                                              10


<210> 23
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
tttttttttt tt                                                           12


<210> 24
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
tttttttttt tttt                                                         14


<210> 25
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
aaaaaa                                                                   6


<210> 26
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
cccccc                                                                   6


<210> 27
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gggggg                                                                   6


<210> 28
<211> 43
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
cuccgaauua ucgggaggau aaggccaaga cccgcgccga ggu                         43


<210> 29
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
uuaucgggag gauaaggcca agacccgcgc cgaggu                                 36


<210> 30
<211> 31
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
gggaggauaa ggccaagacc cgcgccgagg u                                      31


<210> 31
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ggauaaggcc aagacccgcg ccgaggu                                           27


<210> 32
<211> 105
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
cuccgaauua ucgggaggau aaguauggau auuuccacaa ucuugaaaga aagauuuguu       60

agccuuuaau ccauucuccu uucccuuuau uuuaucugac aacau                      105


<210> 33
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
auggauauuu ccacaaucuu gaaagaaaga uuuguuagcc uuuaauccau                  50


<210> 34
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
aaggccaaga cccgcgccga ggu                                               23


<210> 35
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
uaaggccaag acccgcgccg aggu                                              24


<210> 36
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
auaaggccaa gacccgcgcc gaggu                                             25


<210> 37
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
gauaaggcca agacccgcgc cgaggu                                            26


<210> 38
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
aggauaaggc caagacccgc gccgaggu                                          28


<210> 39
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
gaggauaagg ccaagacccg cgccgaggu                                         29


<210> 40
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ggaggauaag gccaagaccc gcgccgaggu                                        30


<210> 41
<211> 95
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
ucgggaggau aaguauggau auuuccacaa ucuugaaaga aagauuuguu agccuuuaau       60

ccauucuccu uucccuuuau uuuaucugac aacau                                  95


<210> 42
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
catgaagcag cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac       60

catcttcttc aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga      120

caccctggtg aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct      180

ggggcacaag ctggagtaca                                                  200


<210> 43
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
gauaaggcau caauaccaaa cucugg                                            26


<210> 44
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
augaaggcca agacccgcgc cgaggu                                            26


<210> 45
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
augaaggcau caauaccaaa cucugg                                            26


<210> 46
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
aaaaaggcca agacccgcgc cgaggu                                            26


<210> 47
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
aaaaaggcau caauaccaaa cucugg                                            26


<210> 48
<211> 60
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
cuuaguuaag gauguuccag guucuuucgg gagccuuggc cuucucccuu aaccuaugcc       60


<210> 49
<211> 75
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
ugguuccauu cuccugagcu ccguugagag cgagaaagag aacuagccuu cccacucauc       60

acuccggcau auucu                                                        75


<210> 50
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcccccu ucuacagugg       60

cc                                                                      62


<210> 51
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcucccc uucuacagug       60

gc                                                                      62


<210> 52
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcauccc cuucuacagu       60

gg                                                                      62


<210> 53
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccaucc ccuucuacag       60

ug                                                                      62


<210> 54
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcucauc cccuucuaca       60

gu                                                                      62


<210> 55
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuucau ccccuucuac       60

ag                                                                      62


<210> 56
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccuuca uccccuucua       60

ca                                                                      62


<210> 57
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgcuuc auccccuucu       60

ac                                                                      62


<210> 58
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcugcuu cauccccuuc       60

ua                                                                      62


<210> 59
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccugcu ucauccccuu       60

cu                                                                      62


<210> 60
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcccugc uucauccccu       60

uc                                                                      62


<210> 61
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuccug cuucaucccc       60

uu                                                                      62


<210> 62
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuuccu gcuucauccc       60

cu                                                                      62


<210> 63
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcguucc ugcuucaucc       60

cc                                                                      62


<210> 64
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuguuc cugcuucauc       60

cc                                                                      62


<210> 65
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcauguu ccugcuucau       60

cc                                                                      62


<210> 66
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuaugu uccugcuuca       60

uc                                                                      62


<210> 67
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgauga agcaggaaca       60

ua                                                                      62


<210> 68
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcggaug aagcaggaac       60

au                                                                      62


<210> 69
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgggau gaagcaggaa       60

ca                                                                      62


<210> 70
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgggga ugaagcagga       60

ac                                                                      62


<210> 71
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcagggg augaagcagg       60

aa                                                                      62


<210> 72
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcaaggg gaugaagcag       60

ga                                                                      62


<210> 73
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgaagg ggaugaagca       60

gg                                                                      62


<210> 74
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcagaag gggaugaagc       60

ag                                                                      62


<210> 75
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuagaa ggggaugaag       60

ca                                                                      62


<210> 76
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcguaga aggggaugaa       60

gc                                                                      62


<210> 77
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuguag aaggggauga       60

ag                                                                      62


<210> 78
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccugua gaaggggaug       60

aa                                                                      62


<210> 79
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcacugu agaaggggau       60

ga                                                                      62


<210> 80
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccacug uagaagggga       60

ug                                                                      62


<210> 81
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcccacu guagaagggg       60

au                                                                      62


<210> 82
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgccac uguagaaggg       60

ga                                                                      62


<210> 83
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcggcca cuguagaagg       60

gg                                                                      62


<210> 84
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgcccu ucuacagugg       60

cc                                                                      62


<210> 85
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcugccc uucuacagug       60

gc                                                                      62


<210> 86
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcaugcc cuucuacagu       60

gg                                                                      62


<210> 87
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccaugc ccuucuacag       60

ug                                                                      62


<210> 88
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcucaug cccuucuaca       60

gu                                                                      62


<210> 89
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuucau gcccuucuac       60

ag                                                                      62


<210> 90
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccuuca ugcccuucua       60

ca                                                                      62


<210> 91
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgcuuc augcccuucu       60

ac                                                                      62


<210> 92
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcugcuu caugcccuuc       60

ua                                                                      62


<210> 93
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccugcu ucaugcccuu       60

cu                                                                      62


<210> 94
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcccugc uucaugcccu       60

uc                                                                      62


<210> 95
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuccug cuucaugccc       60

uu                                                                      62


<210> 96
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuuccu gcuucaugcc       60

cu                                                                      62


<210> 97
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcguucc ugcuucaugc       60

cc                                                                      62


<210> 98
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuguuc cugcuucaug       60

cc                                                                      62


<210> 99
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcauguu ccugcuucau       60

gc                                                                      62


<210> 100
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuaugu uccugcuuca       60

ug                                                                      62


<210> 101
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccauga agcaggaaca       60

ua                                                                      62


<210> 102
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgcaug aagcaggaac       60

au                                                                      62


<210> 103
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcggcau gaagcaggaa       60

ca                                                                      62


<210> 104
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgggca ugaagcagga       60

ac                                                                      62


<210> 105
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcagggc augaagcagg       60

aa                                                                      62


<210> 106
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcaaggg caugaagcag       60

ga                                                                      62


<210> 107
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgaagg gcaugaagca       60

gg                                                                      62


<210> 108
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcagaag ggcaugaagc       60

ag                                                                      62


<210> 109
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuagaa gggcaugaag       60

ca                                                                      62


<210> 110
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcguaga agggcaugaa       60

gc                                                                      62


<210> 111
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcuguag aagggcauga       60

ag                                                                      62


<210> 112
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccugua gaagggcaug       60

aa                                                                      62


<210> 113
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcacugu agaagggcau       60

ga                                                                      62


<210> 114
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggccacug uagaagggca       60

ug                                                                      62


<210> 115
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcccacu guagaagggc       60

au                                                                      62


<210> 116
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcgccac uguagaaggg       60

ca                                                                      62


<210> 117
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
uauuuccaca aucuugaaag aaagauuguu agccuuugau aaggcggcca cuguagaagg       60

gc                                                                      62


<210> 118
<211> 1056
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasM.21524 sequence

<400> 118
Met Lys Gly Tyr Arg Leu His Asp Gln Arg Ile Ala Tyr Ser Gly Gly 
1               5                   10                  15      


Thr Gly Ser Met Arg Ser Ile Lys Tyr Glu Leu Val Asp Thr Asp Gly 
            20                  25                  30          


Ser Glu Gly Leu Arg Asp Lys Val Ala Gly Ala Ile Ala Asn Asp Tyr 
        35                  40                  45              


Arg Thr Leu Tyr Gly Pro Leu Asn Phe Asp Asp Tyr Leu Ala Gly Asn 
    50                  55                  60                  


Arg Thr Pro Ser Leu Ile Asp Phe Trp Leu Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Phe Val Phe Ser Asn Gln Asn Ser Ile Glu Ser Glu Phe Leu Glu Tyr 
                85                  90                  95      


Leu Gly Lys Lys Thr Ile Trp Gln Asn Cys Tyr Glu Cys Leu Ser Asp 
            100                 105                 110         


Glu Leu Lys Gly Val Val Asp Glu Gln Ala Phe Cys Gln Phe Leu Ile 
        115                 120                 125             


Lys Ser His Arg Ser Val Glu Lys Lys Thr Asp Glu Gln Arg Gln Lys 
    130                 135                 140                 


Ile Ile Leu Asn Leu Val Lys Lys Gly Cys Asp Thr Ser Ala Leu Leu 
145                 150                 155                 160 


Pro Val Ala Lys Asp Trp Ser Gln Lys Phe Ser Leu Asp Thr Asp Gln 
                165                 170                 175     


Leu Gln Leu Lys Cys Glu Ile Phe Gly Ile Pro Val Pro Ile Val Pro 
            180                 185                 190         


Gln Arg Asp Leu Ser Leu Ser Phe Ala Val Asp Pro Asn Phe Val Val 
        195                 200                 205             


Met Asp Cys Ser Asp Arg Thr Glu Phe Leu Asp Gln Ile Ile Lys Phe 
    210                 215                 220                 


Tyr Glu Asp Lys Val Gly Ala Ala Gln Ala Lys Lys Phe Leu Ala Ile 
225                 230                 235                 240 


Gly Asp Asn Gly Asn Tyr Phe Asn Gly Leu Phe Gly Asn Leu Leu Thr 
                245                 250                 255     


Cys Leu Lys Gln Gly Glu Val Asp Ser Val Ala Glu Phe Leu Asp Ser 
            260                 265                 270         


Thr Tyr Glu Leu Asn Asn Lys Val Glu Ile Ser Lys Arg Leu Ala Glu 
        275                 280                 285             


Leu Lys Glu Leu Ala Asp Lys Ile Gly Glu Pro Glu Leu Val Asn Lys 
    290                 295                 300                 


Trp Ser Asp Tyr Arg Ser Asp Phe Asn Gly Thr Ile Glu Ser Trp Tyr 
305                 310                 315                 320 


Ser Asn Arg Ile Ser Lys Gln Gln Ala Thr Leu Glu Gln Leu Asp Gly 
                325                 330                 335     


Lys Ile Asp Lys Lys Thr Gly Glu Val Thr Gly Gly Leu Lys Glu Leu 
            340                 345                 350         


Leu Lys Asn Ile Ser Asp Ala Leu Pro Glu Gly Asn Asp Ile Lys Glu 
        355                 360                 365             


Gly Ile Leu Ala Glu Thr Ile Ala Phe Leu Arg Gly His Gly Ala Arg 
    370                 375                 380                 


Ile Asp Arg Lys Phe Thr Asp Glu Leu Glu Ser Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Lys Thr Asp Leu Asn Glu Trp Ser Gln Asn Asn Lys Glu His Lys Met 
                405                 410                 415     


Pro Thr Gly Trp Gln Arg Glu Leu Ser Lys Arg Val Gln Ser Ser Pro 
            420                 425                 430         


Leu Phe Phe Gly Glu Asn Lys Tyr Ala Leu Trp Glu Gln Leu Ile Arg 
        435                 440                 445             


Leu Lys Gly Leu Ile Arg Asp Glu Val Ala Lys Leu Glu Ala Val Leu 
    450                 455                 460                 


Gln Gly Gln Phe Glu Asp Tyr Ala Ile Thr Asp Lys Gln Val Asp Met 
465                 470                 475                 480 


Leu Ala Gln Leu Ala Gln Arg Ile Asp Gly Asp Gly Asn Pro Glu Val 
                485                 490                 495     


Ile Arg Arg Leu Ala Asp Ile Glu Arg Glu Leu Gln Val Asn Phe Gly 
            500                 505                 510         


Glu Arg Ser Glu Arg Ala Arg Tyr Phe Ile Ser Gly Phe Glu Arg Ser 
        515                 520                 525             


Lys Val Thr Gln Leu Glu Ile Gly Asn Arg Ile Asn Val Ser Lys Leu 
    530                 535                 540                 


Ala Glu Leu Ala Asp Leu Gly Glu Leu Tyr Asp Lys Leu Lys Asn Ala 
545                 550                 555                 560 


Pro Gln Asp Asn Tyr Val Leu Arg Asp Thr Ala Gln Leu Ser Lys Ile 
                565                 570                 575     


Val Val Ser Ala Leu Val His Gly Ser Asp Lys Glu Arg Glu Val Val 
            580                 585                 590         


Leu Met His Ser Asn Leu Ser Gly Tyr Ala Ser Leu Ile Ser Arg Arg 
        595                 600                 605             


Glu Phe Ile Thr Arg Cys Thr Val Gln Ala Val Asn Gly Gly Gln Leu 
    610                 615                 620                 


Asn Leu Gly Val Arg Gly Asn Lys Tyr Phe Tyr Ala Phe Leu Pro Asp 
625                 630                 635                 640 


Lys Phe Asp Ala Arg Ser Asp Val Gln Leu Phe Ser Lys Thr Tyr Asn 
                645                 650                 655     


Phe Thr Lys Ala Asp Leu Lys Asp Asn Thr Ser Ser Val Pro Leu Leu 
            660                 665                 670         


Ala Val Arg Ser Ser Lys Tyr Gln Val Gln Phe Leu Asp Trp Phe Met 
        675                 680                 685             


Gly Arg His Ser Arg Lys Lys Thr Glu Leu Gly Ala Gly Gly Ala Phe 
    690                 695                 700                 


Ser Ile Ala Glu Lys Thr Val Lys Leu Asp Trp Ser Gly Glu Thr Pro 
705                 710                 715                 720 


Arg Ile Ala Glu Ile Ser Asp Pro Arg Val Phe Val Ser Gln Pro Phe 
                725                 730                 735     


Glu Ile Lys Pro Leu Gly Lys Gly Thr Gln Ala Ser Asp Asn Arg Phe 
            740                 745                 750         


Ile Gly Val Asp Ile Gly Glu Tyr Gly Leu Ala Trp Ser Leu Ile Glu 
        755                 760                 765             


Val Asn Gly Asn Asn Val Glu Arg Leu Glu Asp Gly Phe Ile Ala Asp 
    770                 775                 780                 


Leu Gln Gln Gln Lys Leu Lys Asn Ala Val Lys Arg Leu Arg Glu Ser 
785                 790                 795                 800 


Gln Val Arg Ala Thr Phe Gly Ser Pro Asp Thr Arg Val Ala Arg Ile 
                805                 810                 815     


Arg Glu Ser Leu Ile Gly Ala Tyr Arg Asn Gln Leu Glu Asp Leu Ala 
            820                 825                 830         


Met Arg Lys Asn Ala Arg Leu Ser Phe Glu Tyr Glu Val Ser Gly Phe 
        835                 840                 845             


Glu Ala Gly Gly Ala Arg Ile Ser Lys Val Tyr Asp Ser Ile Lys Arg 
    850                 855                 860                 


Gly Asp Ile Arg Lys Lys Asp Asn Asn Ala Ala Asn Lys Met Ala Trp 
865                 870                 875                 880 


Gly Asp Phe Gly Val Asn Asn Trp Gly Phe Glu Thr Thr Ala Ala Gly 
                885                 890                 895     


Thr Ser Gln Thr Cys Ser Lys Cys Arg Arg Trp Ala Ser Leu Ala Ile 
            900                 905                 910         


Glu Asp Gly Lys Ser Tyr Arg Leu Gly Glu Tyr Gln Asp Lys Leu Phe 
        915                 920                 925             


Lys Ala Gln Ile Ala Asp Gly Glu Val Arg Leu Leu Ala Lys Gln Asp 
    930                 935                 940                 


Thr Gly Glu Thr Val Lys Gly Lys Asp Leu Lys Gly Leu Ile Tyr Lys 
945                 950                 955                 960 


Ala Met Arg Pro Asn Asp Asp Gly Leu Gly Met Ala Ile Val Lys Arg 
                965                 970                 975     


Gln Met Asp Trp Asp Lys Leu Ser Lys Asp Phe Gly Ala Gly Lys Pro 
            980                 985                 990         


Arg Gly Asn Ile Ala Ile Phe Val  Cys Pro Tyr Thr Asp  Cys His His 
        995                 1000                 1005             


Ile Ala  Asp Ala Asp Leu Gln  Ala Ala Leu Asn Ile  Ala Ile Arg 
    1010                 1015                 1020             


Gly Tyr  Gly Lys Arg Lys Ser  Asp Gly Lys Met Gly  Lys Val Asn 
    1025                 1030                 1035             


Asp Phe  Ala Glu Phe Thr Lys  Glu Leu Gln Tyr Asp  Pro Val Gly 
    1040                 1045                 1050             


Phe Ala  Ser 
    1055     


<210> 119
<211> 1338
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasM.21518 sequence

<400> 119
Met Asn Lys Lys Ser Ser Asn Ser Thr Gly Tyr Arg Leu His Lys Asp 
1               5                   10                  15      


Arg Ile Leu Phe Ser Gly Gly Glu Ile Met Arg Thr Ile Lys Tyr Pro 
            20                  25                  30          


Leu Val Val Glu Lys Asn Asn Leu Asn Ser Glu Glu Ile Val Glu Lys 
        35                  40                  45              


Ile Arg Gln Ala Ile Ile Asn Asp Asp Arg Val Ile Arg Ser Asp Ile 
    50                  55                  60                  


Asn Leu Asn Asp Tyr Ile Glu Tyr Thr Lys Lys Gly Asn Arg Leu Tyr 
65                  70                  75                  80  


Thr Leu Ile Asp Phe Trp Gln Asp Cys Leu Arg Ala Gly Val Ile Trp 
                85                  90                  95      


Gln Pro Ser Thr Ser Phe Leu Leu Tyr Leu Ile Asn Lys Leu Tyr Ser 
            100                 105                 110         


Lys Pro Lys Ala Ile Glu Leu Ile Glu Asn Ala Lys Pro Asp Ile Ser 
        115                 120                 125             


Arg Phe Phe Asp Val Asp Lys Phe Ser Lys Cys Phe Ile Leu Pro Gly 
    130                 135                 140                 


Glu Ile Arg Glu Gly Lys Ile Leu Lys Thr Phe Lys Arg Glu Leu Ile 
145                 150                 155                 160 


Glu Ala Leu Lys Gly Glu Phe Lys Lys Gly Lys Lys Glu Lys Ile Lys 
                165                 170                 175     


Asp Glu Asp Asp Tyr Leu Glu Lys Phe Val Glu Lys Asp Ala Arg Lys 
            180                 185                 190         


Leu Ile Arg Glu Ile Ala Asp Cys Phe Phe Ser Asn Asp Ile Leu Val 
        195                 200                 205             


Thr His Asp Leu Lys Glu Gly Lys Lys Glu Tyr Gln Asp Arg Leu Trp 
    210                 215                 220                 


Glu Glu Lys Phe Gly Ile Lys Lys Gly Lys Leu Leu Glu Asn Phe Lys 
225                 230                 235                 240 


Leu Pro Asp His Leu Arg Asn Phe Lys Asn Ile Ser Phe Phe Ile Ile 
                245                 250                 255     


Pro Glu Leu Ser Asp Lys Ser Lys Asn Phe Asp Glu Leu Ile Glu Leu 
            260                 265                 270         


Arg Arg Lys Trp Leu Leu Glu Arg Lys Ile Cys Val Arg Glu Asp Gly 
        275                 280                 285             


Asp Tyr Leu Glu Asn Glu Lys Lys Leu Asp Glu Glu Leu Arg Asn Leu 
    290                 295                 300                 


Val Gly Leu Ser Asp Asn Cys Asn Pro Leu Ser Asn Phe Leu Gly Thr 
305                 310                 315                 320 


Val Phe Cys Glu Leu Leu Val Pro Asn Asn Leu Asn Glu Asp Asn Ala 
                325                 330                 335     


Leu Glu Lys Phe Tyr Asp Val Phe Thr Ile Val Glu Pro Lys Ile Ala 
            340                 345                 350         


Glu Leu Asn Ile Lys Asp Gln Ile Met Gly Ser Leu Glu Phe Leu Arg 
        355                 360                 365             


Leu Arg Ala Lys Gln Leu Gly Ser Pro Asn Leu Val Asn Phe Ser Lys 
    370                 375                 380                 


Ser Gln Asn Leu Lys Ala Asn Glu Ser Ile Lys Leu Asp Gly Trp Ser 
385                 390                 395                 400 


Leu Tyr Arg Gln Asn Phe Gly Ser Lys Met Gln Ser Trp Phe Thr Ser 
                405                 410                 415     


Tyr Ile Glu Arg Asn Lys Leu Leu Glu Asp Ser Leu Lys Asn Phe Lys 
            420                 425                 430         


Glu Lys Ile Lys Lys Ala Gln Asn Phe Ile Lys Asn Leu Lys Asn Ile 
        435                 440                 445             


Ser Glu Glu Pro Gln Gln Glu Glu Glu Ala Gln Gln Glu Lys Glu Glu 
    450                 455                 460                 


Ile Val Glu Leu Phe Glu Lys Ile Phe Ser Ser Leu Glu Lys Val Asn 
465                 470                 475                 480 


Arg Glu Asn Phe Glu Val Phe Asp Ser Leu Leu Ser Ser Leu Arg Lys 
                485                 490                 495     


Arg Leu Asn Phe Phe Tyr Gln Gln Tyr Leu Tyr Asn Glu Ala Lys Glu 
            500                 505                 510         


Gly Asp Asp Val Lys Lys His Lys Ile Leu Gly Pro Ile Phe Lys Asn 
        515                 520                 525             


Ile Glu Lys Pro Ile Ala Phe Tyr Gly Glu Thr Gln Arg Lys Lys Asn 
    530                 535                 540                 


Glu Lys Phe Val Glu Asp Thr Ile Pro Ile Leu Glu Glu Gly Thr Val 
545                 550                 555                 560 


Phe Leu Thr Thr Leu Ile Ser Asn Leu Leu Asp Ser Phe Ser Pro Lys 
                565                 570                 575     


Gln Val Phe Pro Asp Val Arg Lys Lys Asp Glu Thr Glu Glu Ile Ile 
            580                 585                 590         


Tyr Arg Lys Glu Leu Gln Phe Phe Trp Asn Lys Leu Lys Asp Leu Ala 
        595                 600                 605             


Val Asn Ser Lys Glu Phe Glu Lys Glu Tyr Gln Asp Ile Ile Glu Ser 
    610                 615                 620                 


Ala Val Asp Glu Ser Glu Leu Ser Lys Leu Lys Glu Leu Phe Val Asn 
625                 630                 635                 640 


Lys Lys Lys Asn Gly Ser Lys Tyr Asn Lys Tyr Thr Phe Tyr Lys Ser 
                645                 650                 655     


Lys Tyr Thr Lys Gly Ser Ile Glu Glu Ile Lys Leu Lys Gly Ser Lys 
            660                 665                 670         


Glu Glu Tyr Leu Leu Arg Phe Glu Lys Leu Ile Lys Ser Leu Thr Asn 
        675                 680                 685             


Phe Leu Thr Gln Phe Asn Arg Asn Lys Leu Leu Gln Asp Lys Asp Leu 
    690                 695                 700                 


Leu Leu Asp Trp Val Glu Leu Ala Lys Asn Ile Val Ser Val Leu Ile 
705                 710                 715                 720 


Arg Phe Ser Thr Asn Thr Glu Phe Ser Leu Asn Glu Ile Lys Ala Gln 
                725                 730                 735     


Ser Gln Phe Lys Lys Ala Lys Asn Tyr Leu Glu Leu Phe Lys Leu Lys 
            740                 745                 750         


Lys Ala Lys Lys Lys Glu Phe Gly Phe Ile Ile Gln Ser Phe Ile Leu 
        755                 760                 765             


Ser Glu Ile Lys Gly Ala Ala Thr Leu Tyr Ser Lys Arg Lys Tyr Ile 
    770                 775                 780                 


Ala Ser Tyr Ser Val Gln Ile Val Gly Ser Asn Asn Lys Phe Lys Leu 
785                 790                 795                 800 


Phe Tyr Gln Pro Leu Asp Ser Ser Ile Asn Ile Ser Gly Gly Pro Lys 
                805                 810                 815     


Asp Phe Val Thr Lys Lys His Lys Tyr Leu Ile Val Phe Gln Asp Leu 
            820                 825                 830         


Lys Asn Val Lys Asn Lys Asp Ala Thr Glu Asn Arg Ile Asn Leu Leu 
        835                 840                 845             


Arg Leu Asn Lys Glu Arg Lys Ile Pro Leu Val Ala Tyr Lys Asp Asp 
    850                 855                 860                 


Leu Val Ser Lys Ser Leu Leu Leu Ser Ser Ser Pro Tyr Gln Leu Gln 
865                 870                 875                 880 


Phe Leu Asp Lys Tyr Leu Tyr Arg Pro Arg Gly Trp Glu Asn Ile Asp 
                885                 890                 895     


Ile Lys Leu Asn Glu Trp Ser Phe Val Val Glu Glu Ala Tyr Asp Ile 
            900                 905                 910         


Glu Trp Asp Leu Asn Ser Lys Thr Pro Lys Leu Ile Pro Ser Pro Lys 
        915                 920                 925             


Ser Asn Arg Asn Lys Leu Tyr Leu Ala Ile Pro Phe Thr Leu Lys Gly 
    930                 935                 940                 


Asn Val Lys Glu Pro Pro Leu Asp Lys Ile Val Leu Lys Ser Glu Thr 
945                 950                 955                 960 


Lys Lys Asp His Ser Arg Asp Lys Asn Arg Leu Asn Tyr Pro Ile Leu 
                965                 970                 975     


Gly Val Asp Val Gly Glu Tyr Gly Val Ala Trp Cys Leu Thr Lys Phe 
            980                 985                 990         


Asp Tyr Asn Gln Asp Phe Ser Leu  Arg Asp Ile Asp Ile  Gln Gly Lys 
        995                 1000                 1005             


Gly Phe  Ile Glu Asp Arg Asn  Ile Gly Lys Ile Lys  Asp Tyr Phe 
    1010                 1015                 1020             


Ala Glu  Ile Gln Gln Lys Ser  Arg Lys Gly Ala Tyr  Asp Glu Asp 
    1025                 1030                 1035             


Asp Thr  Thr Ile Ala Lys Val  Arg Glu Asn Ala Ile  Gly Lys Leu 
    1040                 1045                 1050             


Arg Asn  Ala Ile His Ser Ile  Leu Thr Gly Ser Leu  Glu Gly Ala 
    1055                 1060                 1065             


Ser Pro  Val Tyr Glu Asp Ala  Ile Ser Asn Phe Glu  Thr Gly Ser 
    1070                 1075                 1080             


Gly Lys  Thr Ile Lys Ile Tyr  Asn Ser Val Lys Arg  Ala Asp Thr 
    1085                 1090                 1095             


Glu Phe  Lys Ser Glu Ala Asp  Lys Ala Glu His Ser  Leu Val Trp 
    1100                 1105                 1110             


Gly Lys  Lys Asp Arg Asn Gln  Glu Thr Lys Tyr Ile  Gly Arg Asn 
    1115                 1120                 1125             


Val Ser  Ala Tyr Ala Ser Ser  Tyr Thr Cys Val Asn  Cys Leu His 
    1130                 1135                 1140             


Thr Leu  Phe Lys Val Lys Lys  Glu Asp Leu Ser Asn  Ile Lys Ile 
    1145                 1150                 1155             


Leu Glu  Lys Asp Gly Arg Ile  Val Thr Met Ser Ser  Pro Tyr Gly 
    1160                 1165                 1170             


Pro Asp  Lys Lys Val Arg Gly  Tyr Leu Ser Glu Lys  Glu Lys Tyr 
    1175                 1180                 1185             


Glu Ile  Gly Tyr Gln Phe Lys  Glu Ser Glu Glu Asp  Leu Lys Ala 
    1190                 1195                 1200             


Phe Arg  Lys Ile Val Arg Asp  Phe Ala Arg Pro Pro  Val Asn Lys 
    1205                 1210                 1215             


Asn Ser  Glu Val Leu Glu Lys  Tyr Ala Lys Glu Ile  Leu Ala Gly 
    1220                 1225                 1230             


Asn Lys  Ile Glu Glu Phe Arg  Lys Lys Arg Gly Asn  Ser Ala Ile 
    1235                 1240                 1245             


Phe Val  Cys Pro Phe Cys Gln  Phe Lys Ala Asp Ala  Asp Ile Gln 
    1250                 1255                 1260             


Ala Ala  Phe Met Met Ala Met  Arg Gly Tyr Leu Arg  Phe Ser Gly 
    1265                 1270                 1275             


Ile Val  Pro Ser Lys Glu Asn  Ser Lys Asn Asn Pro  Gln Glu Ser 
    1280                 1285                 1290             


Glu Asp  Lys Ser Leu Lys Asn  Ser Lys Lys Gln Ser  Glu Thr Gly 
    1295                 1300                 1305             


Asp Thr  Phe Leu Thr Lys Thr  Ala Glu Tyr Leu Gln  Gln Leu Arg 
    1310                 1315                 1320             


Phe Glu  Ile Lys Glu Lys Ile  Lys Glu Ala Val Lys  Val Asp Phe 
    1325                 1330                 1335             


<210> 120
<211> 1258
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasM.21520 sequence

<400> 120
Met Asn Glu Lys Lys Thr Ala Thr Gln Arg Arg Asn Ala Arg Arg Arg 
1               5                   10                  15      


Arg Gly Glu Arg Ala Arg Thr Lys Ser Gln Glu Leu Arg Gly Tyr Arg 
            20                  25                  30          


Leu His Asp Ala Arg Ile Glu Phe Ser Gly Gly Leu Gly Ser Met Arg 
        35                  40                  45              


Thr Val Lys Val Glu Leu Leu Asn Pro Asp Ser Ser Arg Glu Asp Pro 
    50                  55                  60                  


Gln Arg Gly Gln Gly Leu Gln Gly Lys Val Ala Lys Ala Val Phe Asp 
65                  70                  75                  80  


Asp Tyr Arg Ala Leu Tyr Gly Pro Met Asn Ile Glu Asp Tyr Leu Ser 
                85                  90                  95      


Asp Pro Asp Cys Pro Ser Phe Leu Gly Leu Trp Val Lys Ala Val Cys 
            100                 105                 110         


Leu Gly Val Ile Met Ser Arg Lys Thr Ala Thr Asp Phe Gly Glu Leu 
        115                 120                 125             


Arg Gly Gly Ser Lys Ser Gly Gln Ala Phe Asp Ser Ile Pro Glu His 
    130                 135                 140                 


Leu Arg Arg Gln Leu Ile Lys Leu Lys Trp Leu Asp Trp Tyr Asp Lys 
145                 150                 155                 160 


Gly Ile Arg Lys Ser Ser Ser Lys Ala Ser Arg Leu Lys Ser Leu Thr 
                165                 170                 175     


Asp Val Phe Ala Asn Pro Lys Gln Pro Asp Gln Gly Val Met Ala Ala 
            180                 185                 190         


Trp Glu Gln Gly Glu Lys Leu Ala Glu Ser Ser Arg Asp Ile Ala Ala 
        195                 200                 205             


Leu Gly Arg Arg Glu Phe Lys Asp Lys Leu Phe Ala Ile Pro Pro Pro 
    210                 215                 220                 


Thr Ser Ser Val Val Leu Asp Asp Asp Val Lys Ala Thr Lys Val Ser 
225                 230                 235                 240 


Arg Asp Trp Gln Trp Ala Val Asp Pro Gln Phe Lys Leu Pro Ser Thr 
                245                 250                 255     


Asp Leu Asp Ile Thr Arg Ala Leu Glu Glu Val Asp Arg Gln Trp Phe 
            260                 265                 270         


Glu Arg Leu Gly Asn Asn Arg Gly Met Val Gln Gln Phe Phe Ala Ile 
        275                 280                 285             


Gly Asp Asn Gly Asn His Leu Asn Asn Gly Leu Phe Gly His Phe Phe 
    290                 295                 300                 


Ala Ser Ile Arg Ser Ala Asn Leu Ala Asp Ile Val Ala Glu Met Gly 
305                 310                 315                 320 


Thr Ala Phe Gly Phe Ser Ala Glu Glu Arg Asp Ile Val Arg Gln Arg 
                325                 330                 335     


Leu Glu Thr Leu His Glu Tyr Ala Gln Gly Leu Pro Glu Lys Pro Val 
            340                 345                 350         


Leu Ala Ser Arg Trp Ala Glu Tyr Arg Thr Asp Met Thr Ala Lys Leu 
        355                 360                 365             


Gly Ser Trp Tyr Ser Asn Arg Thr Ser Lys Gly Ala Ala Ser Ile Thr 
    370                 375                 380                 


Gln Val Trp Gly Thr Ile Asn Thr Glu Thr Gly Glu Val Lys Asp Asp 
385                 390                 395                 400 


Gly Leu Val Arg Thr Leu Glu Asn Ile Gln Ser Asp Leu Pro Asp Ser 
                405                 410                 415     


Cys Ser Ile Lys Glu Gly Ile Leu Gln Glu Thr Leu Asp Phe Ile Gly 
            420                 425                 430         


Asp Arg Arg Ser Ser Thr Asp Arg Ala Phe Thr Asp Glu Leu Glu Leu 
        435                 440                 445             


Tyr Leu Ala Thr Leu Arg Ser Asp Leu Asn Thr Trp Cys Gln Glu Gln 
    450                 455                 460                 


Ser Ala Leu Trp Glu Glu Lys Gln Arg Gln Val Ala Thr Pro Ala Ser 
465                 470                 475                 480 


Asp Glu Lys Ser Lys Lys Ala Asp Asn Pro Trp Ala Gly Lys Gly Ser 
                485                 490                 495     


Lys Thr Asp Lys Trp Leu Gly Ala Leu His Thr Arg Ile Gln Ser Ser 
            500                 505                 510         


Pro Leu Phe Trp Gly Val Asp Lys Leu Glu Leu Trp Lys Thr Leu Ala 
        515                 520                 525             


Asn Leu Lys Gln Ala Ile Arg Asp Glu Ile Asp Lys Leu Asn Glu Gln 
    530                 535                 540                 


Val Glu Val Phe Gly Arg Ser Ala Tyr Asp Glu Pro Val Gly Lys Asp 
545                 550                 555                 560 


Ala Asp Ser Gly Glu Gly Asp Arg Arg Val Asp Gln Leu Ser Tyr Leu 
                565                 570                 575     


Ser Ala Arg Leu Gly Asp Gln Ala His Glu Glu Val Arg Gln Arg Leu 
            580                 585                 590         


Asp Ala Ile Ala Leu Ala Leu Gly Val Lys Phe Ser Glu Arg Asp Asp 
        595                 600                 605             


Leu His Arg Phe Phe Val Ser Ser Arg Ala Arg Arg Arg Ala Ala Leu 
    610                 615                 620                 


Leu Ala Met Pro Asn Thr Ile Thr Val Gly Lys Leu Arg Glu Leu Ala 
625                 630                 635                 640 


Asp Leu Thr Pro Leu Trp Glu Arg Ile Lys Lys Lys Pro Glu Glu Pro 
                645                 650                 655     


Arg Leu Leu Ala Asp Thr Val Ala Leu Ser Lys Val Val Asn Ser Ala 
            660                 665                 670         


Cys Ala Ser Arg Ala Asn Pro Ser Asp Gln Ile Glu Leu Thr Thr Ile 
        675                 680                 685             


His Ser Arg Leu Asp Gly Tyr Ser Lys Asn Ile Gly His Thr Glu Phe 
    690                 695                 700                 


Ile Ser Arg Ala Thr Val Gln Ser Thr Asn Gly Ala Gln Asn Thr Val 
705                 710                 715                 720 


Ala Leu Asp Ser Leu Val Ser Pro Arg Leu Phe Tyr Tyr Asn Phe Pro 
                725                 730                 735     


Asn Ile Val Glu Ser Ala Glu Pro His Val Ser His Leu Glu Val Ala 
            740                 745                 750         


Thr Arg Gly Asn Leu Gly Ser Phe Glu Glu Phe Ala Ala Lys Glu His 
        755                 760                 765             


Arg Thr Phe Asp Arg Glu Asn Pro Gln Lys Asp Ser Arg Asn Arg Ile 
    770                 775                 780                 


Asp Ser Val Asn Pro Leu Ala Val Ala Ser Ser Arg Tyr Gln Ile Gln 
785                 790                 795                 800 


Phe Phe Thr Trp Trp Ala Gly Leu His Arg Ser Lys Glu Thr Ala Leu 
                805                 810                 815     


Glu Val Gly Gly Ser Phe Thr Ile Ala Glu Arg Gln Val Arg Leu Asp 
            820                 825                 830         


Trp Ser Gln Glu Lys Pro Gln Ala Val Val Ser Glu Glu Leu Arg Val 
        835                 840                 845             


Phe Val Ser Gln Pro Phe Thr Ile Val Pro Asp Asp Lys Lys Arg Pro 
    850                 855                 860                 


Ala Thr Ser Gly Thr Arg Tyr Ile Gly Val Asp Ile Gly Glu Tyr Gly 
865                 870                 875                 880 


Leu Ala Trp Ser Cys Trp Glu Phe Ala Pro Gly Tyr Trp Asn Gly Ser 
                885                 890                 895     


Val Val Asn Pro Ser Lys Val Thr Cys Leu Asp Tyr Gly Phe Leu Ala 
            900                 905                 910         


Glu Pro Gly Gln Arg Arg Ile Val Glu Arg Val Lys Lys Leu Arg Glu 
        915                 920                 925             


Ser Gln Ala Thr Lys Thr Phe Thr Ser Pro Asp Thr Tyr Ile Ala Arg 
    930                 935                 940                 


Leu Arg Glu Asn Val Val Ala Thr Tyr Gln Ala Gln Leu Glu Ala Leu 
945                 950                 955                 960 


Met Met Ala Tyr Asn Ala Gln Leu Val Phe Glu Ser Glu Ile Ser Ala 
                965                 970                 975     


Phe Glu Thr Gly Gly Asn Arg Val Lys Lys Ile Tyr Asp Ala Ile Lys 
            980                 985                 990         


Arg Ser Ser Val Phe Gly Arg Ser  Asp Ala Glu Ala Thr  Asp Asn Asn 
        995                 1000                 1005             


Gln His  Trp Gly Lys Asn Gly  Asn Arg Ser Ser Val  Lys Asp Pro 
    1010                 1015                 1020             


Asp Lys  Leu Arg Leu Asn Glu  Ala Gly Gln Val Ala  Ala Arg Val 
    1025                 1030                 1035             


Pro Trp  Ala Glu Pro Val Ser  Ala Trp Met Thr Ser  Gln Thr Cys 
    1040                 1045                 1050             


Ser Ala  Cys Gly Arg Val Tyr  Val Arg Ala Tyr Arg  Gly Lys Asn 
    1055                 1060                 1065             


Ser Asn  Glu Pro Asp Ser Gly  Ala Thr Gly Glu Val  Arg Tyr Phe 
    1070                 1075                 1080             


Asp Asn  Lys Gln Gln Lys Ile  Leu Thr Lys Thr Ile  Gly Ala Asp 
    1085                 1090                 1095             


Thr Val  Trp Val Thr Asp Gln  Glu Arg Lys Glu Phe  Glu Arg Gly 
    1100                 1105                 1110             


Val Tyr  Asn Ala Met Arg Pro  Asn Ala Phe Met Pro  Asp Gly Arg 
    1115                 1120                 1125             


Trp Thr  Ala Ala Gly Glu Ile  Leu Glu Ala Ala Leu  Lys Ser Arg 
    1130                 1135                 1140             


Gly Thr  Leu Asp Gly Gly Arg  Gly Phe Ala Gly Leu  His Leu Thr 
    1145                 1150                 1155             


Ser Lys  Ala Gln Val His Glu  Tyr Ile Glu Gly Thr  Gly Lys Ser 
    1160                 1165                 1170             


His Arg  Asp Ala His Gly Asn  Ser Ala Ile Phe Ile  Cys Pro Tyr 
    1175                 1180                 1185             


Thr Asp  Cys Gly His Ile Ala  Asp Ala Asp Leu Gln  Ala Ser Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Leu Arg Gly Phe  Ala Tyr Ala Ile Val  Arg Lys Lys 
    1205                 1210                 1215             


His Pro  Glu Leu Phe Ala Gly  Ser Gly Ser Ser Thr  Asp Gly Asp 
    1220                 1225                 1230             


Glu Gly  Gly Gly Lys Lys Pro  Gln Gln Lys Gln Ala  Phe Ile Asp 
    1235                 1240                 1245             


Glu Ile  Val Arg Ala Ala Gly  Arg Ala Ser 
    1250                 1255             


<210> 121
<211> 895
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasM.21522 sequence

<400> 121
Asn Pro Leu Gly Ile Thr Ala Cys Leu Leu Pro Gly Phe Glu Thr Pro 
1               5                   10                  15      


Asp Ala Tyr Arg Ala Gly Arg Asp Val Thr Leu Leu Tyr His Val Gln 
            20                  25                  30          


Arg Met Gln Arg Leu Leu Ser Leu Asp Glu Val Lys Glu Ala Tyr Glu 
        35                  40                  45              


Phe Val Gly Met His Asp Ser Ala Leu Ser Asn Phe Leu Asn Gly Asn 
    50                  55                  60                  


Ser Asn Lys Gly Phe Leu Ala Leu Leu Leu Arg Gly Glu Phe Asp Thr 
65                  70                  75                  80  


Leu Ala Arg Gly Met Met Asp Met Thr Pro Leu Trp Asn Glu His Asn 
                85                  90                  95      


His Asp Val Leu Met Asn Arg Leu Gln Ala Leu Gly Arg Asn Ala Gln 
            100                 105                 110         


Lys Leu Ser Phe Thr Lys Pro Arg Phe Gly Asn Ser Phe Ala Asp His 
        115                 120                 125             


Arg Lys Gln Ile Ser Gly Lys Ala Thr Ala Trp Phe Ser Gly Tyr Cys 
    130                 135                 140                 


Asn Lys Leu Asp Ile Ala Lys Glu Gln Ile Pro Leu Val Leu Glu Asp 
145                 150                 155                 160 


Ala Lys Met Phe Met Glu Met Leu Cys Ala Val Glu Ile Asp Tyr Glu 
                165                 170                 175     


Lys Glu Glu Phe Met His Leu Gln Leu Ser Ala Phe Ile Glu Arg Met 
            180                 185                 190         


Glu Arg Ala His Glu Arg Leu Asp Ala Asp Gly Val Val Ala Leu Lys 
        195                 200                 205             


Lys Ala Gln Tyr Val Leu Pro Ile Ile Arg Glu Phe Ala Asn Pro Ile 
    210                 215                 220                 


Val Gln Arg Glu Glu Ala Gln Gln Trp Leu Ser Leu Asn Ile Glu Leu 
225                 230                 235                 240 


Val Pro Asp Lys Arg Phe Thr Phe Lys Gln Ala Phe Pro Tyr Leu Ser 
                245                 250                 255     


Asp Gln Gly Gly Ala Asp Thr Glu Lys Gly Glu Gln Thr Lys Phe Gln 
            260                 265                 270         


Ser Val Pro Arg Phe Phe Ala Glu Gly Ala His Ala Glu Tyr Val Ala 
        275                 280                 285             


Phe Ser Gln Ala Pro Met Ile Phe Ser Val Tyr Met Glu Asn Leu Arg 
    290                 295                 300                 


Leu Leu Trp Asp Arg Leu Ile Gly Met Glu Arg Arg Thr Pro Arg Asn 
305                 310                 315                 320 


Trp Glu Glu His Leu Ser Lys Leu Leu Tyr Tyr Leu Tyr Val Asp Ile 
                325                 330                 335     


Tyr Val Glu Cys Arg Thr Asp Ala Cys Lys Lys Tyr Val Arg Gly Ile 
            340                 345                 350         


Leu Glu Thr Tyr Ala His Val Ser Arg Ile Pro Glu His Val Pro Gly 
        355                 360                 365             


Ile Lys Arg Phe Thr Ile Lys Pro Gly Tyr Thr Pro Gln Gly Gly Leu 
    370                 375                 380                 


Thr Lys Asp Gln Leu Val Gln Cys Val Leu Gln Ile Ala Gln Arg Leu 
385                 390                 395                 400 


Ser Asn Ala Gly Phe Glu Trp Lys Arg Ile Ser Ala Leu Glu Arg Leu 
                405                 410                 415     


Asp Leu Val Glu Val His Lys Lys Ala Phe Ala Phe Leu Val Gly Ile 
            420                 425                 430         


Thr His Gly Ser Val Asp Val Ser Ala Tyr Asn Trp Leu Asn Asn Lys 
        435                 440                 445             


Ser Val Val Gln Tyr Leu Asp Val Leu Lys Thr Thr Asp Leu Gly Gly 
    450                 455                 460                 


Ile Arg Leu Ala Arg Phe Leu Gln Ser Cys Val Cys Ala Thr Leu Arg 
465                 470                 475                 480 


Gly Ser Ala Thr Arg Met Ser Glu Gln Met Leu Thr Ala Arg Phe Ser 
                485                 490                 495     


Val Gln Thr Ala Thr Thr Ile Pro Gln Cys Glu Leu Val Tyr Ala Val 
            500                 505                 510         


Ser Glu Tyr Met Arg Lys Arg Arg Phe Val Thr Pro Pro Ser His Val 
        515                 520                 525             


Ser Arg Asp Val Leu Asp Arg Lys Pro Ala Ser Ile Val Ala Gln Ala 
    530                 535                 540                 


Ile Tyr Asn Pro Glu Gln Met Ala Gly Ser Met Arg Phe Ile Pro His 
545                 550                 555                 560 


Arg Phe Gly Tyr Gln Ile Gln Leu Pro Glu Leu Ala Arg His Glu Ser 
                565                 570                 575     


Leu Asn Asn Ala Leu Val Val Gln Lys Pro Thr Ser Thr Arg Arg Tyr 
            580                 585                 590         


Ser Phe Ala Arg Phe Asp Ala Glu Lys Gly Pro Val Leu Trp Val Glu 
        595                 600                 605             


Ser Ser His Tyr Gln Gln Gln Tyr Phe Asp Trp Phe Phe Phe Ala Pro 
    610                 615                 620                 


Asn Asn Arg Pro Ala Asp Val Ile Pro Gln Gly Val Ser Leu Val Val 
625                 630                 635                 640 


Glu Gln Asp Ile Ala Leu Gln Trp Asp Phe Asp Ala Leu Val Val His 
                645                 650                 655     


Met Gln Pro Val His Glu Pro Arg Met Tyr Cys Pro Gln Pro Phe Lys 
            660                 665                 670         


Phe Val Pro Arg Val Glu Ser Ser Val Met Gln Asn Arg Tyr Met Gly 
        675                 680                 685             


Ile Ala Pro Gly Thr Asn Glu Val Ala Tyr Ala Val Ile Glu Val Asn 
    690                 695                 700                 


Gly Thr Arg Val Ser Val Ile Asn Cys Gly Thr Phe Pro Leu Ala Gly 
705                 710                 715                 720 


Phe Ala Asn Leu Ser Arg Ala Glu Glu Lys Lys Gln Lys Arg Glu Arg 
                725                 730                 735     


Arg Val Gly Ser His Ala Phe Ser Pro Asp Lys Arg Ala Ile Val Leu 
            740                 745                 750         


Asp Asn Ser Ala Asn Lys Leu Ala Asn Gln Ile His Ala Cys Ala Ile 
        755                 760                 765             


Gln Asn Arg Ala Arg Leu Val Trp Gln Trp Thr Pro Gln Thr Val Gln 
    770                 775                 780                 


Ile Ala Lys Gly Arg Glu Val Asp Met Val Tyr Ala Arg Ala Arg Lys 
785                 790                 795                 800 


Ser Cys Ala Pro Lys Asn Asp Ser Asp Phe Asp Ala Met Lys Thr Lys 
                805                 810                 815     


Trp Gly Lys Ile Trp Ser Ala Lys Trp Glu Asp Gly Lys His Thr Leu 
            820                 825                 830         


Ser Thr Glu Val Tyr Tyr Ala Glu Ser Leu Phe Gln Ser Ala Cys Asn 
        835                 840                 845             


Ala Pro Val Pro Pro Glu Cys Ala Thr Ala Leu Met Val Ala Leu Leu 
    850                 855                 860                 


Gly Arg Val Arg Asp Ile Ala Thr Pro Lys Lys Trp Glu Asp Asp Ala 
865                 870                 875                 880 


Trp Arg Ala Asp Thr Leu Ala Glu Leu Phe Gln Gln Ile Thr His 
                885                 890                 895 


<210> 122
<211> 1184
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasM.21516 sequence

<400> 122
Met Phe Asn Gln Lys Lys Gly Tyr Arg Leu His Leu Glu Arg Ile Ile 
1               5                   10                  15      


Tyr Ser Gly Gly Glu Ile Thr Arg Ser Ile Lys Tyr Leu Leu Ala Ser 
            20                  25                  30          


His Ser Asp Ser Gln Lys Asn Lys Glu Leu Leu Asn Asn Phe Ser Gln 
        35                  40                  45              


Asp Leu Tyr Asn Asp Asp Leu Lys Ile Arg Gly Cys Leu Asn Leu Asn 
    50                  55                  60                  


Asp Leu Val Asn Asn Asn Gln Ile Tyr Asn Leu Ala Asp Phe Trp Ile 
65                  70                  75                  80  


Asp Ser Leu Arg Ala Gly Val Ile Trp Gln Ser Ser Ala Ser Ser Leu 
                85                  90                  95      


Ile Asp Phe Ile Lys Arg Leu Asn His Gln Glu Thr Ile Gly Glu Lys 
            100                 105                 110         


Ile Phe Asn Asn Ala Asn Glu Arg Ile Lys Arg Phe Phe Asn Ser Glu 
        115                 120                 125             


Lys Phe Ile Lys Glu Ile Ile Leu Ser Glu Pro Lys Arg Ile Ser Ser 
    130                 135                 140                 


Lys Lys Gln Ala Phe Tyr Asn Ser Leu Phe Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Phe Lys Lys Gln Glu Lys Asn Glu Lys Ile Ile Ile Asp Asn Lys Ala 
                165                 170                 175     


Glu Gln Leu Ile Lys Glu Ile Val Asp Ala Phe Tyr Ser Asn Asp Gly 
            180                 185                 190         


Val Phe Leu Met Glu Gly Glu Glu Lys Gln Asn Asn Phe Trp Gln Glu 
        195                 200                 205             


Lys Phe Asn Ile Asp Lys Asn Met Ile Lys Lys Glu Lys Glu Asp Ile 
    210                 215                 220                 


Leu Lys Asp Val Gly Asp Ile Thr Ala Phe Ile His Pro Pro Leu Ile 
225                 230                 235                 240 


Ile Leu Lys Gly Asp Val Ser Gln Leu Ile Asp Glu Arg Lys Lys Tyr 
                245                 250                 255     


Phe Ser Glu Lys Asp Leu Glu Glu Ile Leu Gly Leu Ser Asp Asn Phe 
            260                 265                 270         


Asn Ala Phe Ser His Tyr Phe Asn Lys Phe Phe Leu Leu Leu Tyr Gln 
        275                 280                 285             


Asp Lys Gln Glu Lys Ile Phe Glu Cys Tyr Gln Lys Ile Phe Ser Phe 
    290                 295                 300                 


Ser Gln Glu Asp Arg Lys Arg Ile Lys Asp Ala Leu Asp Phe Leu Leu 
305                 310                 315                 320 


Glu Lys Ser Lys Leu Leu Gly Leu Pro Lys Ile Val Asn Ser Trp Ser 
                325                 330                 335     


Asp Tyr Arg Ser Val Phe Gly Gly Lys Ile Lys Ser Trp Phe Ser Asn 
            340                 345                 350         


Tyr Leu Asn Arg Glu Asp Lys Ala Lys Lys Gln Glu Lys Lys Ile Lys 
        355                 360                 365             


Glu Gly Leu Glu Lys Val Asn Lys Phe Leu Leu Asp Phe Ile Gln Lys 
    370                 375                 380                 


Asn Gln Val Asp Ser Asp Leu Gln Gln Glu Ile Lys Phe Tyr Tyr Asp 
385                 390                 395                 400 


Lys Leu Asn Gln Phe Ile Asn Ser Tyr Gln Asn Gln Glu Phe Phe His 
                405                 410                 415     


Gln Gln Glu Leu Phe Leu Leu Phe Ser Asp Leu Leu Ala Glu Tyr Arg 
            420                 425                 430         


Glu Lys Leu Asn Arg Phe Tyr Gln Lys Tyr Leu Ser Asp Lys Glu Lys 
        435                 440                 445             


Glu Glu Lys Lys Val Asp Glu Phe Pro Leu Phe Lys Asp Leu Phe Glu 
    450                 455                 460                 


Lys Tyr Glu Gly Pro Ile Ser Phe Tyr Gly Lys Thr Lys Leu Glu Asp 
465                 470                 475                 480 


Asn Lys Lys Ile Ile Asp Leu Thr Phe Lys Thr Ile Lys Val Gly Leu 
                485                 490                 495     


Asn Leu Ile Arg Arg Leu Leu Ile Asp Leu Tyr Asn Ser Ser Asp Phe 
            500                 505                 510         


Lys Asn Ser Asp Asn Asn Asn Gln Glu Arg Asp Leu Arg Arg Ile Phe 
        515                 520                 525             


Glu Phe Leu Leu Asn Lys Ile Pro Ala Thr Lys Thr Phe Arg Glu Lys 
    530                 535                 540                 


Tyr Leu Ser Ile Leu Lys Asp Asn Phe Asp Gln Gln Thr Tyr Lys Glu 
545                 550                 555                 560 


Met Thr Leu Lys Pro Ser Arg Tyr Thr Phe Val Glu Asn Ile Tyr Ser 
                565                 570                 575     


Arg Glu Asn Arg Lys Leu Ile Glu Leu Pro Ser Lys Asn Phe Glu Glu 
            580                 585                 590         


Leu Leu Ser Lys Ile Ile Lys Asp Leu Thr Asp Phe Ser Leu Ser Phe 
        595                 600                 605             


Lys Asn Asp Asp Leu Phe Val Asp Ile Tyr Leu Leu Ser Asp Leu Val 
    610                 615                 620                 


Glu Leu Ala Lys Thr Leu Ile Ser Leu Val Ile Asn Tyr Ser Asn Lys 
625                 630                 635                 640 


Ser Gln Phe Asp Ser Tyr Lys Asn Glu Leu Ile Asp Asp Thr Tyr Gln 
                645                 650                 655     


Lys Ala Lys Lys Tyr Leu Glu Thr Phe Lys Ile Ser Phe Phe Asn Ser 
            660                 665                 670         


Lys Lys Glu Ala Asn Tyr Phe Tyr Gln Thr Arg Val Leu Ser Glu Leu 
        675                 680                 685             


Lys Gly Ala Val Ala Leu Phe Ser Lys Lys Tyr Tyr Gln Ala Lys Tyr 
    690                 695                 700                 


Asn Ile Gln Ile Leu Lys Ser Asn Glu Ile Phe Pro Leu Phe Val Lys 
705                 710                 715                 720 


Phe Ser Asp Leu Leu Lys Lys Glu Glu Ile Asn Asp Ile Asn Lys Leu 
                725                 730                 735     


Lys Leu Ile Phe Lys Lys Pro Tyr Arg Tyr Leu Ile Ala Leu Lys Lys 
            740                 745                 750         


Ile Lys Phe Lys Lys Lys Gln Gln Gln Ser Ser Val Ile His Leu Asp 
        755                 760                 765             


Lys Lys Asn Lys Asp Leu Val Leu Ile Ser Pro Gln Asp Glu Asp Phe 
    770                 775                 780                 


Leu Phe Lys Leu Thr Ser Ser Phe Tyr Gln Leu Gln Phe Leu Asp Arg 
785                 790                 795                 800 


Phe Val Tyr Pro Val Lys Lys Trp Leu Asn Val Asp Ile Thr Leu Ser 
                805                 810                 815     


Glu Trp Ser Phe Ile Leu Glu Lys Lys Tyr Lys Ile Asn Trp Asp Phe 
            820                 825                 830         


Asn Asn Gly Lys Pro Glu Phe Ser Glu Ile Asp Ser Arg Leu Tyr Leu 
        835                 840                 845             


Asn Ile Pro Phe Lys Ile Lys Ala Ile Asn Gln Gln Lys Ile Leu Lys 
    850                 855                 860                 


Pro Lys Glu Leu Phe Leu Gly Ile Asp Val Gly Glu Tyr Gly Val Gly 
865                 870                 875                 880 


Tyr Ala Leu Val Asn Phe Lys Asp Glu Glu Ile Lys Ile Ile Lys Ser 
                885                 890                 895     


Gly Phe Ile Arg Ser Lys Asn Ile Ala Ser Ile Arg Asp Lys Tyr Arg 
            900                 905                 910         


Leu Leu Gln Asp Arg Ser Lys Lys Gly Val Tyr Phe Ser Ser Thr Asn 
        915                 920                 925             


Val Val Gln Glu Val Arg Glu Asn Ala Ile Gly Glu Ile Arg Asn Gln 
    930                 935                 940                 


Ile His Asp Ile Leu Ile Lys Asn Asn Ala Asp Leu Ile Tyr Glu Tyr 
945                 950                 955                 960 


Asn Ile Ser Asn Phe Glu Thr Gly Ser Gly Arg Ile Thr Lys Ile Tyr 
                965                 970                 975     


Asp Ser Ile Lys Lys Ser Asp Val Tyr Ala Glu Asn Glu Ala Asp Lys 
            980                 985                 990         


Ser Val Ile Gln His Val Trp Gly  Ile Lys Lys Ser Ile  Ala Ser His 
        995                 1000                 1005             


Leu Ser  Ala Tyr Gly Ser Ser  Tyr Thr Cys Ser Asn  Cys Gly Arg 
    1010                 1015                 1020             


Ser Ile  Phe Ser Phe Ser Glu  Asn Asp Ile Phe Ser  Ser Lys Val 
    1025                 1030                 1035             


Ile Lys  Arg Asp Gly Asn Ile  Ile Thr Ile Gln Thr  Pro Lys Gly 
    1040                 1045                 1050             


Glu Val  Phe Ala Tyr Ser Lys  Asp Lys Lys Phe Asn  Ile Gly Tyr 
    1055                 1060                 1065             


Ser Phe  Ser Gln Glu Lys Asn  Lys Glu Glu Met Lys  Asn Leu Phe 
    1070                 1075                 1080             


Met Lys  Ile Val Lys Ala Tyr  Ala Arg Pro Pro Leu  Leu Lys Ser 
    1085                 1090                 1095             


Glu Val  Leu Leu Thr Gln Lys  Lys Leu Asp Arg Glu  Phe Leu Glu 
    1100                 1105                 1110             


Lys Phe  Lys Lys Glu Arg Gly  Asn Ser Ala Ile Phe  Val Cys Pro 
    1115                 1120                 1125             


Phe Val  Asp Cys Gln Ser Leu  Ala Asp Ser Asp Ile  Gln Ala Ala 
    1130                 1135                 1140             


Phe Ile  Met Ala Leu Arg Gly  Tyr Leu Lys Lys Lys  Lys Gly Lys 
    1145                 1150                 1155             


Asp Ile  Asn Tyr Leu Glu Glu  Ser Leu Asn Tyr Leu  Gln Asn Phe 
    1160                 1165                 1170             


Lys Gly  Lys Ile Asn Phe Ser  Asn Leu Leu His 
    1175                 1180                 


<210> 123
<211> 1192
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasM.21466 sequence

<400> 123
Met Ala Glu Ser Lys Gln Met Gln Cys Arg Lys Cys Gly Ala Ser Met 
1               5                   10                  15      


Lys Tyr Glu Val Ile Gly Leu Gly Lys Lys Ser Cys Arg Tyr Met Cys 
            20                  25                  30          


Pro Asp Cys Gly Asn His Thr Ser Ala Arg Lys Ile Gln Asn Lys Lys 
        35                  40                  45              


Lys Arg Asp Lys Lys Tyr Gly Ser Ala Ser Lys Ala Gln Ser Gln Arg 
    50                  55                  60                  


Ile Ala Val Ala Gly Ala Leu Tyr Pro Asp Lys Lys Val Gln Thr Ile 
65                  70                  75                  80  


Lys Thr Tyr Lys Tyr Pro Ala Asp Leu Asn Gly Glu Val His Asp Arg 
                85                  90                  95      


Gly Val Ala Glu Lys Ile Glu Gln Ala Ile Gln Glu Asp Glu Ile Gly 
            100                 105                 110         


Leu Leu Gly Pro Ser Ser Glu Tyr Ala Cys Trp Ile Ala Ser Gln Lys 
        115                 120                 125             


Gln Ser Glu Pro Tyr Ser Val Val Asp Phe Trp Phe Asp Ala Val Cys 
    130                 135                 140                 


Ala Gly Gly Val Phe Ala Tyr Ser Gly Ala Arg Leu Leu Ser Thr Val 
145                 150                 155                 160 


Leu Gln Leu Ser Gly Glu Glu Ser Val Leu Arg Ala Ala Leu Ala Ser 
                165                 170                 175     


Ser Pro Phe Val Asp Asp Ile Asn Leu Ala Gln Ala Glu Lys Phe Leu 
            180                 185                 190         


Ala Val Ser Arg Arg Thr Gly Gln Asp Lys Leu Gly Lys Arg Ile Gly 
        195                 200                 205             


Glu Cys Phe Ala Glu Gly Arg Leu Glu Ala Leu Gly Ile Lys Asp Arg 
    210                 215                 220                 


Met Arg Glu Phe Val Gln Ala Ile Asp Val Ala Gln Thr Ala Gly Gln 
225                 230                 235                 240 


Arg Phe Ala Ala Lys Leu Lys Ile Phe Gly Ile Ser Gln Met Pro Glu 
                245                 250                 255     


Ala Lys Gln Trp Asn Asn Asp Ser Gly Leu Thr Val Cys Ile Leu Pro 
            260                 265                 270         


Asp Tyr Tyr Val Pro Glu Glu Asn Arg Ala Asp Gln Leu Val Val Leu 
        275                 280                 285             


Leu Arg Arg Leu Arg Glu Ile Ala Tyr Cys Met Gly Ile Glu Asp Glu 
    290                 295                 300                 


Ala Gly Phe Glu His Leu Gly Ile Asp Pro Gly Ala Leu Ser Asn Phe 
305                 310                 315                 320 


Ser Asn Gly Asn Pro Lys Arg Gly Phe Leu Gly Arg Leu Leu Asn Asn 
                325                 330                 335     


Asp Ile Ile Ala Leu Ala Asn Asn Met Ser Ala Met Thr Pro Tyr Trp 
            340                 345                 350         


Glu Gly Arg Lys Gly Glu Leu Ile Glu Arg Leu Ala Trp Leu Lys His 
        355                 360                 365             


Arg Ala Glu Gly Leu Tyr Leu Lys Glu Pro His Phe Gly Asn Ser Trp 
    370                 375                 380                 


Ala Asp His Arg Ser Arg Ile Phe Ser Arg Ile Ala Gly Trp Leu Ser 
385                 390                 395                 400 


Gly Cys Ala Gly Lys Leu Lys Ile Ala Lys Asp Gln Ile Ser Gly Val 
                405                 410                 415     


Arg Thr Asp Leu Phe Leu Leu Lys Arg Leu Leu Asp Ala Val Pro Gln 
            420                 425                 430         


Ser Ala Pro Ser Pro Asp Phe Ile Ala Ser Ile Ser Ala Leu Asp Arg 
        435                 440                 445             


Phe Leu Glu Ala Ala Glu Ser Ser Gln Asp Pro Ala Glu Gln Val Arg 
    450                 455                 460                 


Ala Leu Tyr Ala Phe His Leu Asn Ala Pro Ala Val Arg Ser Ile Ala 
465                 470                 475                 480 


Asn Lys Ala Val Gln Arg Ser Asp Ser Gln Glu Trp Leu Ile Lys Glu 
                485                 490                 495     


Leu Asp Ala Val Asp His Leu Glu Phe Asn Lys Ala Phe Pro Phe Phe 
            500                 505                 510         


Ser Asp Thr Gly Lys Lys Lys Lys Lys Gly Ala Asn Ser Asn Gly Ala 
        515                 520                 525             


Pro Ser Glu Glu Glu Tyr Thr Glu Thr Glu Ser Ile Gln Gln Pro Glu 
    530                 535                 540                 


Asp Ala Glu Gln Glu Val Asn Gly Gln Glu Gly Asn Gly Ala Ser Lys 
545                 550                 555                 560 


Asn Gln Lys Lys Phe Gln Arg Ile Pro Arg Phe Phe Gly Glu Gly Ser 
                565                 570                 575     


Arg Ser Glu Tyr Arg Ile Leu Thr Glu Ala Pro Gln Tyr Phe Asp Met 
            580                 585                 590         


Phe Cys Asn Asn Met Arg Ala Ile Phe Met Gln Leu Glu Ser Gln Pro 
        595                 600                 605             


Arg Lys Ala Pro Arg Asp Phe Lys Cys Phe Leu Gln Asn Arg Leu Gln 
    610                 615                 620                 


Lys Leu Tyr Lys Gln Thr Phe Leu Asn Ala Arg Ser Asn Lys Cys Arg 
625                 630                 635                 640 


Ala Leu Leu Glu Ser Val Leu Ile Ser Trp Gly Glu Phe Tyr Thr Tyr 
                645                 650                 655     


Gly Ala Asn Glu Lys Lys Phe Arg Leu Arg His Glu Ala Ser Glu Arg 
            660                 665                 670         


Ser Ser Asp Pro Asp Tyr Val Val Gln Gln Ala Leu Glu Ile Ala Arg 
        675                 680                 685             


Arg Leu Phe Leu Phe Gly Phe Glu Trp Arg Asp Cys Ser Ala Gly Glu 
    690                 695                 700                 


Arg Val Asp Leu Val Glu Ile His Lys Lys Ala Ile Ser Phe Leu Leu 
705                 710                 715                 720 


Ala Ile Thr Gln Ala Glu Val Ser Val Gly Ser Tyr Asn Trp Leu Gly 
                725                 730                 735     


Asn Ser Thr Val Ser Arg Tyr Leu Ser Val Ala Gly Thr Asp Thr Leu 
            740                 745                 750         


Tyr Gly Thr Gln Leu Glu Glu Phe Leu Asn Ala Thr Val Leu Ser Gln 
        755                 760                 765             


Met Arg Gly Leu Ala Ile Arg Leu Ser Ser Gln Glu Leu Lys Asp Gly 
    770                 775                 780                 


Phe Asp Val Gln Leu Glu Ser Ser Cys Gln Asp Asn Leu Gln His Leu 
785                 790                 795                 800 


Leu Val Tyr Arg Ala Ser Arg Asp Leu Ala Ala Cys Lys Arg Ala Thr 
                805                 810                 815     


Cys Pro Ala Glu Leu Asp Pro Lys Ile Leu Val Leu Pro Ala Gly Ala 
            820                 825                 830         


Phe Ile Ala Ser Val Met Lys Met Ile Glu Arg Gly Asp Glu Pro Leu 
        835                 840                 845             


Ala Gly Ala Tyr Leu Arg His Arg Pro His Ser Phe Gly Trp Gln Ile 
    850                 855                 860                 


Arg Val Arg Gly Val Ala Glu Val Gly Met Asp Gln Gly Thr Ala Leu 
865                 870                 875                 880 


Ala Phe Gln Lys Pro Thr Glu Ser Glu Pro Phe Lys Ile Lys Pro Phe 
                885                 890                 895     


Ser Ala Gln Tyr Gly Pro Val Leu Trp Leu Asn Ser Ser Ser Tyr Ser 
            900                 905                 910         


Gln Ser Gln Tyr Leu Asp Gly Phe Leu Ser Gln Pro Lys Asn Trp Ser 
        915                 920                 925             


Met Arg Val Leu Pro Gln Ala Gly Ser Val Arg Val Glu Gln Arg Val 
    930                 935                 940                 


Ala Leu Ile Trp Asn Leu Gln Ala Gly Lys Met Arg Leu Glu Arg Ser 
945                 950                 955                 960 


Gly Ala Arg Ala Phe Phe Met Pro Val Pro Phe Ser Phe Arg Pro Ser 
                965                 970                 975     


Gly Ser Gly Asp Glu Ala Val Leu Ala Pro Asn Arg Tyr Leu Gly Leu 
            980                 985                 990         


Phe Pro His Ser Gly Gly Ile Glu  Tyr Ala Val Val Asp  Val Leu Asp 
        995                 1000                 1005             


Ser Ala  Gly Phe Lys Ile Leu  Glu Arg Gly Thr Ile  Ala Val Asn 
    1010                 1015                 1020             


Gly Phe  Ser Gln Lys Arg Gly  Glu Arg Gln Glu Glu  Ala His Arg 
    1025                 1030                 1035             


Glu Lys  Gln Arg Arg Gly Ile  Ser Asp Ile Gly Arg  Lys Lys Pro 
    1040                 1045                 1050             


Val Gln  Ala Glu Val Asp Ala  Ala Asn Glu Leu His  Arg Lys Tyr 
    1055                 1060                 1065             


Thr Asp  Val Ala Thr Arg Leu  Gly Cys Arg Ile Val  Val Gln Trp 
    1070                 1075                 1080             


Ala Pro  Gln Pro Lys Pro Gly  Thr Ala Pro Thr Ala  Gln Thr Val 
    1085                 1090                 1095             


Tyr Ala  Arg Ala Val Arg Thr  Glu Ala Pro Arg Ser  Gly Asn Gln 
    1100                 1105                 1110             


Glu Asp  His Ala Arg Met Lys  Ser Ser Trp Gly Tyr  Thr Trp Gly 
    1115                 1120                 1125             


Thr Tyr  Trp Glu Lys Arg Lys  Pro Glu Asp Ile Leu  Gly Ile Ser 
    1130                 1135                 1140             


Thr Gln  Val Tyr Trp Thr Gly  Gly Ile Gly Glu Ser  Cys Pro Ala 
    1145                 1150                 1155             


Val Ala  Val Ala Leu Leu Gly  His Ile Arg Ala Thr  Ser Thr Gln 
    1160                 1165                 1170             


Thr Glu  Trp Glu Lys Glu Glu  Val Val Phe Gly Arg  Leu Lys Lys 
    1175                 1180                 1185             


Phe Phe  Pro Ser 
    1190         


<210> 124
<211> 68
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
cuucgccucg uccucggagc aagcuccugu gggcgagccu uugaaaaggc uauuaaauac       60

ucguauug                                                                68


<210> 125
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 125
uuuuccccaa cugaaagguu ggaugccuuu caaaaggcua uuaaauacuc guauug           56


<210> 126
<211> 59
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 126
auguuccagg uucuuucggg agccuuggcc uuuaugaagg cuauuaaaua cucguauug        59


<210> 127
<211> 83
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 127
gccaguuugg gaaaccuggg ucuuuauuuu uaaagacaca ggaauucccg cgucuuugua       60

aagacuauua aauacucgua uug                                               83


<210> 128
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
cuuuuccuuc cccaaaaggg aaguugccuu uuaaaaggcu auuaaauacu cguauug          57


<210> 129
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> a, c, t, g, unknown or other

<400> 129
nnnnntr                                                                  7


<210> 130
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 130
gcgaugaagg c                                                            11


<210> 131
<211> 200
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Target sequence

<400> 131
cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac       60

agcttgtctg taagcggatg cctgcccgca gactaatcaa taccaaactc tggaccgcgt      120

aaactttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg      180

ggagaggcgg tttgcgtatt                                                  200


<210> 132
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 132
agccuuugau aaggc                                                        15


<210> 133
<211> 73
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 133
gggaggauaa guauggauau uuccacaauc uugaaagaaa gauuuguuag ccuuuaaucc       60

auucuccuuu ccc                                                          73


<210> 134
<211> 71
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 134
gggaggauaa guauggauau uuccacaauc uugaaagaaa gauuuguuag ccuuuaaucc       60

auucuccuuu c                                                            71


<210> 135
<211> 68
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 135
ggauaaguau ggauauuucc acaaucuuga aagaaagauu uguuagccuu uaauccauuc       60

uccuuucc                                                                68


<210> 136
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 136
aguauggaua uuuccacaau cuugaaagaa agauuuguua gccuuuaauc cauucu           56


<210> 137
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 137
auggauauuu ccacaaucuu gaaagaaaga uuuguuagcc uuuaauccau                  50


<210> 138
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 138
auggauauuu ccacaaucuu gaaagaaaga uuuguuagcc uucgauccau                  50


<210> 139
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 139
uauuuccaca aucuugaaag aaagauuugu uagccuuuaa                             40


<210> 140
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 140
uauuuccaca aucuugaaag aaagauuugu uagccuuuaa uccau                       45


<210> 141
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 141
auggauaaaa ggccaaucuu gaaagaaaga uuuguuagcc uuuaauccau                  50


<210> 142
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 142
auggauauuu ccacaaucuu gaaagaaaga uuuguaugcc uuuaauccau                  50


<210> 143
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 143
aagauuuguu agccuuuaau ccaugaaaga auggauauuu ccacaaucuu                  50


<210> 144
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 144
auggauccaa uuacaaucuu gaaagaaaga uuuguuagcc uuuaauccau                  50


<210> 145
<211> 105
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 145
cuccgaauua ucgggaggau aaguauggau auuuccacaa ucuugaaaga aagauuuguu       60

agccuuuaau ccauucuccu uucccuuuau uuuaucugac aacau                      105


<210> 146
<211> 63
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 146
uauuuccaca aucuugaaag aaagauuugu uagccuuuga uaaggccaag acccgcgccg       60

agg                                                                     63


<210> 147
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 147
gauaaggcca agacccgcgc cgagguga                                          28


<210> 148
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 148
atgttcctgc ttcatcccct tctacagtgg ccttat                                 36


<210> 149
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 149
atgttcctgc ttcatgcctt tctacagtgg ccttat                                 36


