                         SEQUENCE LISTING

<110>  ҩҵϺɷ޹˾
 
<120>  NGFĿ塢Ʊ;

<130>  SH363-21P450334

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Composite

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Gly Tyr 
            20                  25                  30          


Asp Leu Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Gly Asp Gly Thr Thr Asp Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Trp Tyr Ala Thr Ser Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  107
<212>  PRT
<213>  Composite

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Glu His Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  3
caggttcagc tccagcagtc tggggctgag ctggcaagac ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cacctttagt aggtactgga tgcagtggat aaaacagagg      120

cctggacagg gtctggaatg gattggggct atttatcctg gagatggtga tacaaggtac      180

agtcagaggg tcaagggcaa ggccacattg actgcagatc aatcctccag tacagtctcc      240

atgcaactca gcagcttggc atctgaggac tctgcggtct attactgtgc aagagaggga      300

aactttgcta actcttttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  4
<211>  119
<212>  PRT
<213>  mus musculus

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Ser Gln Arg Val 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Gln Ser Ser Ser Thr Val Ser 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Phe Ala Asn Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  5
<211>  321
<212>  DNA
<213>  mus musculus

<400>  5
gatattcaga tgacacagac tacatcctcc ctgtctgcct ctctggggga cagagtcacc       60

atccgttgca ggccaagtca ggacattggt aatcatttaa actggtatca gcagaagcca      120

gatggaactg ttaaactcct gatctacttc acatcaagat tatactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa tctggagcaa      240

gaagatattg ccacttactt ttgccaccag ggttatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  6
<211>  107
<212>  PRT
<213>  mus musculus

<400>  6

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Arg Cys Arg Pro Ser Gln Asp Ile Gly Asn His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys His Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  5
<212>  PRT
<213>  mus musculus

<400>  7

Arg Tyr Trp Met Gln 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  mus musculus

<400>  8

Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Ser Gln Arg Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  mus musculus

<400>  9

Glu Gly Asn Phe Ala Asn Ser Phe Asp Tyr 
1               5                   10  


<210>  10
<211>  11
<212>  PRT
<213>  mus musculus

<400>  10

Arg Pro Ser Gln Asp Ile Gly Asn His Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  mus musculus

<400>  11

Phe Thr Ser Arg Leu Tyr Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  mus musculus

<400>  12

His Gln Gly Tyr Thr Leu Pro Tyr Thr 
1               5                   


<210>  13
<211>  119
<212>  PRT
<213>  Composite

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Ser Gln Arg Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Gln Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Phe Ala Asn Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  107
<212>  PRT
<213>  Composite

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Asp Ile Gly Asn His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys His Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  357
<212>  DNA
<213>  Composite

<400>  15
caggtgcagc tcgtgcagtc tggcgctgaa gtgaaaaaac ctggagcttc tgtgaaggtg       60

tcttgtaagg ccagtggcta cacattttct agatactgga tgcagtggat tagacaggct      120

cctggacagg gtctggagtg gattggcgct atctatccag gcgatggtga cacaagatat      180

tctcagagag tgaagggcag ggccacactg actgctgatc agtctacatc tactgtgtat      240

atggaactgt cttctctgag atccgaggac accgccgtgt actactgcgc cagggagggc      300

aacttcgcca actccttcga ctactggggc cagggcaccc tggtgaccgt gtcctcc         357


<210>  16
<211>  1347
<212>  DNA
<213>  Composite

<400>  16
caggtgcagc tcgtgcagtc tggcgctgaa gtgaaaaaac ctggagcttc tgtgaaggtg       60

tcttgtaagg ccagtggcta cacattttct agatactgga tgcagtggat tagacaggct      120

cctggacagg gtctggagtg gattggcgct atctatccag gcgatggtga cacaagatat      180

tctcagagag tgaagggcag ggccacactg actgctgatc agtctacatc tactgtgtat      240

atggaactgt cttctctgag atccgaggac accgccgtgt actactgcgc cagggagggc      300

aacttcgcca actccttcga ctactggggc cagggcaccc tggtgaccgt gtcctccgcg      360

agcaccaagg gaccttccgt gtttcccctc gcccccagct ccaaaagcac cagcggcgga      420

acagctgctc tcggctgtct cgtcaaggat tacttccccg agcccgtgac cgtgagctgg      480

aacagcggag ccctgacaag cggcgtccac accttccctg ctgtcctaca gtcctccgga      540

ctgtacagcc tgagcagcgt ggtgacagtc cctagcagct ccctgggcac ccagacatat      600

atttgcaacg tgaatcacaa gcccagcaac accaaggtcg ataagaaggt ggagcctaag      660

tcctgcgaca agacccacac atgtcccccc tgtcccgctc ctgaactgct gggaggccct      720

tccgtgttcc tgttcccccc taagcccaag gacaccctga tgatttccag gacacccgag      780

gtgacctgtg tggtggtgga cgtcagccac gaggaccccg aggtgaaatt caactggtac      840

gtcgatggcg tggaggtgca caacgctaag accaagccca gggaggagca gtacaattcc      900

acctacaggg tggtgtccgt gctgaccgtc ctccatcagg actggctgaa cggcaaagag      960

tataagtgca aggtgagcaa caaggccctc cctgctccca tcgagaagac catcagcaaa     1020

gccaagggcc agcccaggga acctcaagtc tataccctgc ctcccagcag ggaggagatg     1080

accaagaacc aagtgagcct cacatgcctc gtcaagggct tctatccttc cgatattgcc     1140

gtcgagtggg agtccaacgg acagcccgag aacaactaca agacaacacc ccccgtgctc     1200

gattccgatg gcagcttctt cctgtactcc aagctgaccg tggacaagtc cagatggcaa     1260

caaggcaacg tcttcagttg cagcgtcatg catgaggccc tccacaacca ctacacccag     1320

aagagcctct ccctgagccc tggaaag                                         1347


<210>  17
<211>  321
<212>  DNA
<213>  Composite

<400>  17
gatatccaga tgacccagtc tccttcttct ctgtctgctt ccgtgggaga cagagtgact       60

atcacctgta gaccttctca ggacattggc aaccacctga attggtacca gcagaagcca      120

ggcaagaccg tgaagctgct gatctacttt acctctagac tgtattctgg cgtgccatct      180

agattttctg gatccggctc tggaacagat tataccctga ccatcagctc tctgcagcct      240

gaggattttg ctacatactt ctgtcatcag ggctatacac tgccttatac atttggccag      300

ggcacaaagg tggagatcaa g                                                321


<210>  18
<211>  642
<212>  DNA
<213>  Composite

<400>  18
gatatccaga tgacccagtc tccttcttct ctgtctgctt ccgtgggaga cagagtgact       60

atcacctgta gaccttctca ggacattggc aaccacctga attggtacca gcagaagcca      120

ggcaagaccg tgaagctgct gatctacttt acctctagac tgtattctgg cgtgccatct      180

agattttctg gatccggctc tggaacagat tataccctga ccatcagctc tctgcagcct      240

gaggattttg ctacatactt ctgtcatcag ggctatacac tgccttatac atttggccag      300

ggcacaaagg tggagatcaa gagaaccgtc gccgctccca gcgtcttcat cttccccccc      360

agcgatgagc agctgaagag cggaaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca atggaaggtg gacaacgccc tacagagcgg caactcccag      480

gagagcgtga ccgagcagga cagcaaggat agcacctaca gcctgagcag caccctcacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccatcagggc      600

ctgagcagcc ctgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  19
<211>  449
<212>  PRT
<213>  Composite

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Ser Gln Arg Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Gln Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Phe Ala Asn Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  20
<211>  214
<212>  PRT
<213>  Composite

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Asp Ile Gly Asn His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys His Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


