                         SEQUENCE LISTING

<110>  Universitt Ulm
 
<120>  Antisense Oligonucleotides for Increasing Shank3 Expression

<130>  UU16098PC

<150>  EP20171521.6
<151>  2020-04-27

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  1900
<212>  DNA
<213>  Homo sapiens

<400>  1
cgccccaccc ccactcccgc cccggccgtg ccctgccggc agggcccccc acccccaccc       60

cgggccgcgg gctcggcctg ccccttacga cggcgcccgg gccaggaatg ttgcatgaat      120

cgtcctgttt gctgttgctc ggagactcgc cctgtacatt gcttagtgcc ctcaccggcc      180

gcccagccca cccagcgcac agtcaggaag ggcgtggacc agggaggctg gggcgggagg      240

tgccgggggt ggggtgccct agcgtgacca cctccttcgc agctcctggt ggccattctc      300

ccagaggggg aacctagtcc agcatgcgag gtcaggaccc gccttggtga ctcgggggga      360

ggggggagac attgggattc tcgatggggg ccaaggagcc cccctgtttt gcatatttta      420

atccactcta tatttggaac gagaaaagga acaaatatct ctgtccgtaa tagtttcctc      480

tcccctccct tctacttcca ctggtcccac tgcagctgcc cagtcttcca tctccggccc      540

ctcactgcca ctgccacccc acaacggggc aggggacgct ccagctggtc tggggttggc      600

cagggcccta gtggcccgcc ctggggcccc agctcggccc ctcgcctcgc tgagctctag      660

tgtgccccac cgacccttca ggtgctgctc gtggtgggag gggcggcagg ccgcgggtcc      720

tgctgtgcac ccgcgggacc agccggcctg ggagaccatc ggccgggggg gatgagggca      780

gggccctgcc gctccaccgc agccatcttc ctcacagggt ctctccccaa ggagggggct      840

agcttggtcc ccatgctctt gggcaactac agcagagaag cctccctgcc ttggacccca      900

aagtctcctg tcctgccctt tatgtgtgtg ggtgaaactg ggtgcgtctg agcacgtggg      960

agccgtgtgt gtgcctgatt actgagtggc caccaggggc cgctctggac tagcgcgggg     1020

ccgtggaggc gtgcaccgtg tgcatgcgtg gggtgtacct gtgagagcac cctgtctcct     1080

cttccaaaga aagtcagagg ccatcctgca ccctgggtcc agctgtttgc ccagcctgtc     1140

cttccagagc ctcacccagc ctgagcgggg ttccctggtg aatccctgct gcttggggag     1200

gccccaaggg ccccttggag gcagcgcccc caccttgggc ttctgagggc atcatagggg     1260

gacccctaga gtcagttcac cacaggccct ggggagagtc aaagaccccc gagggtgccc     1320

agccccccac actgtgactc ctcacactca gcgatgacct gtggggtggg gggccctggg     1380

acgtttttaa acctagggtt tggagtctgg actaagctcc atccacgtca ctcacaagtt     1440

tctgtttata tttctagctt tttttaataa aataaaaaaa aaaagaaaac agaagttttc     1500

acaacccagg ggcctggcac gccggtctgt gcctgcccgc cccgccctgg cccaccggcc     1560

ccactccctg ggcacagagt cacacccact catccttccg ccaacagtcc aggtcacaca     1620

gcagcagtca ctgtaacaga ctgccacata cacactcggt ctcacactca cctgtgggtt     1680

ttggttccgt tcaatttggg tttttaactt tacagggtca gttccgcttc acctcctttt     1740

gtatggagtt ccatccgggg ggtttcaccc cctgctccag tcctgaggcc tcctgaccct     1800

gacgttgtga tacgccccac agagatctat gtttcttata ttattattat tgataataat     1860

tattataata ttattatgta ataaatttat aagaaatgaa                           1900


<210>  2
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse complement of bp 1 to 600 of SEQ ID NO:1

<400>  2
gccaacccca gaccagctgg agcgtcccct gccccgttgt ggggtggcag tggcagtgag       60

gggccggaga tggaagactg ggcagctgca gtgggaccag tggaagtaga agggagggga      120

gaggaaacta ttacggacag agatatttgt tccttttctc gttccaaata tagagtggat      180

taaaatatgc aaaacagggg ggctccttgg cccccatcga gaatcccaat gtctcccccc      240

tccccccgag tcaccaaggc gggtcctgac ctcgcatgct ggactaggtt ccccctctgg      300

gagaatggcc accaggagct gcgaaggagg tggtcacgct agggcacccc acccccggca      360

cctcccgccc cagcctccct ggtccacgcc cttcctgact gtgcgctggg tgggctgggc      420

ggccggtgag ggcactaagc aatgtacagg gcgagtctcc gagcaacagc aaacaggacg      480

attcatgcaa cattcctggc ccgggcgccg tcgtaagggg caggccgagc ccgcggcccg      540

gggtgggggt ggggggccct gccggcaggg cacggccggg gcgggagtgg gggtggggcg      600


<210>  3
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse complement of bp 100 to 300 of SEQ ID NO:1

<400>  3
gagaatggcc accaggagct gcgaaggagg tggtcacgct agggcacccc acccccggca       60

cctcccgccc cagcctccct ggtccacgcc cttcctgact gtgcgctggg tgggctgggc      120

ggccggtgag ggcactaagc aatgtacagg gcgagtctcc gagcaacagc aaacaggacg      180

attcatgcaa cattcctggc c                                                201


<210>  4
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON2

<400>  4
tggcccgggc gccgtcgtaa ggggcaggcc gagcccgcgg cccggggtgg                  50


<210>  5
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON3

<400>  5
cagggcgagt ctccgagcaa cagcaaacag gacgattcat gcaacattcc                  50


<210>  6
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON4

<400>  6
gactgtgcgc tgggtgggct gggcggccgg tgagggcact aagcaatgta                  50


<210>  7
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON5

<400>  7
ccccaccccc ggcacctccc gccccagcct ccctggtcca cgcccttcct                  50


<210>  8
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON9

<400>  8
ttgttccttt tctcgttcca aatatagagt ggattaaaat atgcaaaaca                  50


<210>  9
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON10

<400>  9
ccagtggaag tagaagggag gggagaggaa actattacgg acagagatat                  50


<210>  10
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON11

<400>  10
gcagtggcag tgaggggccg gagatggaag actgggcagc tgcagtggga                  50


<210>  11
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON12

<400>  11
cctggccaac cccagaccag ctggagcgtc ccctgccccg ttgtggggtg                  50


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.1-3

<400>  12
tccacgccct tcctgact                                                     18


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.1-6

<400>  13
aagcaatgta cagggcga                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.2-2

<400>  14
ggcacctccc gccccagc                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.2-4

<400>  15
tcctgactgt gcgctggg                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.2-5

<400>  16
tgggctgggc ggccggtg                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.2-6

<400>  17
agggcactaa gcaatgta                                                     18


<210>  18
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scr (scrambled)

<400>  18
ggcgctccga tggttccaat gaacacgtcg cccacgccgg atgagcttct                  50


<210>  19
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON1

<400>  19
gggtgggggg ccctgccggc agggcacggc cggggcggga gtgggggtgg                  50


<210>  20
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AON6

<400>  20

Cys Thr Gly Gly Gly Ala Gly Ala Ala Thr Gly Gly Cys Cys Ala Cys 
1               5                   10                  15      


Cys Ala Gly Gly Ala Gly Cys Thr Gly Cys Gly Ala Ala Gly Gly Ala 
            20                  25                  30          


Gly Gly Thr Gly Gly Thr Cys Ala Cys Gly Cys Thr Ala Gly Gly Gly 
        35                  40                  45              


Cys Ala 
    50  


<210>  21
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON7

<400>  21
cgagtcacca aggcgggtcc tgacctcgca tgctggacta ggttccccct                  50


<210>  22
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON8

<400>  22
ggggggctcc ttggccccca tcgagaatcc caatgtctcc cccctccccc                  50


<210>  23
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON13

<400>  23
ctcagcgagg cgaggggccg agctggggcc ccagggcggg ccactagggc                  50


<210>  24
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON14

<400>  24
gcccctccca ccacgagcag cacctgaagg gtcggtgggg cacactagag                  50


<210>  25
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON15

<400>  25
ctcccaggcc ggctggtccc gcgggtgcac agcaggaccc gcggcctgcc                  50


<210>  26
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON16

<400>  26
ggctgcggtg gagcggcagg gccctgccct catccccccc ggccgatggt                  50


<210>  27
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON17

<400>  27
atggggacca agctagcccc ctccttgggg agagaccctg tgaggaagat                  50


<210>  28
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON18

<400>  28
actttggggt ccaaggctgg gaggcttctc tgctgtcgtt gcccaagagc                  50


<210>  29
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON19

<400>  29
tgctcagacg cacccagttt cacccacaca cataaagggc aggacaggag                  50


<210>  30
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON20

<400>  30
agcggcccct ggtggccact cagtaatcag gcacacacac ggctcccacg                  50


<210>  31
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON21

<400>  31
accccacgca tgcacacggt gcacgcctcc acggccccgc gctagtccag                  50


<210>  32
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON22

<400>  32
atggcctctg actttctttg gaagaggaga cagggtgctc tcacaggtac                  50


<210>  33
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON23

<400>  33
tgaggctctg gaaggacagg ctgggcaaac agctggaccc agggtgcagg                  50


<210>  34
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON24

<400>  34
gggcctcccc aagcagcagg gattcaccag ggaaccccgc tcaggctggg                  50


<210>  35
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON25

<400>  35
tgatgccctc agaagcccaa ggtgggggcg ctgcctccaa ggggcccttg                  50


<210>  36
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON26

<400>  36
ctttgactct ccccagggcc tgtggtgaac tgactctagg ggtcccccta                  50


<210>  37
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON27

<400>  37
tcgctgagtg tgaggagtca cagtgtgggg ggctgggcac cctcgggggt                  50


<210>  38
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON28

<400>  38
tccaaaccct aggtttaaaa acgtcccagg gccccccacc ccacaggtca                  50


<210>  39
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON29

<400>  39
gaaatataaa cagaaacttg tgagtgacgt ggatggagct tagtccagac                  50


<210>  40
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON30

<400>  40
ttgtgaaaac ttctgttttc tttttttttt tattttatta aaaaaagcta                  50


<210>  41
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON31

<400>  41
tgggccaggg cggggcgggc aggcacagac cggcgtgcca ggcccctggg                  50


<210>  42
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON32

<400>  42
ttggcggaag gatgagtggg tgtgactctg tgcccaggga gtggggccgg                  50


<210>  43
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON33

<400>  43
tgtgtatgtg gcagtctgtt acagtgactg ctgctgtgtg acctggactg                  50


<210>  44
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON34

<400>  44
aaaacccaaa ttgaacggaa ccaaaaccca caggtgagtg tgagaccgag                  50


<210>  45
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON35

<400>  45
atggaactcc atacaaaagg aggtgaagcg gaactgaccc tgtaaagtta                  50


<210>  46
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON36

<400>  46
cgtcagggtc aggaggcctc aggactggag cagggggtga aaccccccgg                  50


<210>  47
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AON37

<400>  47
atcaataata ataatataag aaacatagat ctctgtgggg cgtatcacaa                  50


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.1-1

<400>  48
ccccaccccc ggcacctc                                                     18


<210>  49
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.1-2

<400>  49
ccgccccagc ctccctgg                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.1-4

<400>  50
gtgcgctggg tgggctgg                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.1-5

<400>  51
gcggccggtg agggcact                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.2-1

<400>  52
ctagggcacc ccaccccc                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.2-3

<400>  53
ctccctggtc cacgccct                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.3-1

<400>  54
agggcacccc acccccgg                                                     18


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.3-2

<400>  55
cacctcccgc cccagcct                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.3-3

<400>  56
ccctggtcca cgcccttc                                                     18


<210>  57
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.3-4

<400>  57
ctgactgtgc gctgggtg                                                     18


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.3-5

<400>  58
ggctgggcgg ccggtgag                                                     18


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.3-6

<400>  59
ggcactaagc aatgtaca                                                     18


<210>  60
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.4-1

<400>  60
ggcaccccac ccccggca                                                     18


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.4-2

<400>  61
cctcccgccc cagcctcc                                                     18


<210>  62
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.4-3

<400>  62
ctggtccacg cccttcct                                                     18


<210>  63
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.4-4

<400>  63
gactgtgcgc tgggtggg                                                     18


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.4-5

<400>  64
ctgggcggcc ggtgaggg                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.4-6

<400>  65
cactaagcaa tgtacagg                                                     18


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.5-1

<400>  66
caccccaccc ccggcacc                                                     18


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.5-2

<400>  67
tcccgcccca gcctccct                                                     18


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.5-3

<400>  68
ggtccacgcc cttcctga                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.5-4

<400>  69
ctgtgcgctg ggtgggct                                                     18


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.5-5

<400>  70
gggcggccgg tgagggca                                                     18


<210>  71
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.5-6

<400>  71
ctaagcaatg tacagggc                                                     18


<210>  72
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.6-1

<400>  72
ccacccccgg cacctccc                                                     18


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.6-2

<400>  73
gccccagcct ccctggtc                                                     18


<210>  74
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.6-3

<400>  74
cacgcccttc ctgactgt                                                     18


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.6-4

<400>  75
gcgctgggtg ggctgggc                                                     18


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.6-5

<400>  76
ggccggtgag ggcactaa                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.6-6

<400>  77
gcaatgtaca gggcgagt                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.7-1

<400>  78
acccccggca cctcccgc                                                     18


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.7-2

<400>  79
cccagcctcc ctggtcca                                                     18


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.7-3

<400>  80
cgcccttcct gactgtgc                                                     18


<210>  81
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.7-4

<400>  81
gctgggtggg ctgggcgg                                                     18


<210>  82
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.7-5

<400>  82
ccggtgaggg cactaagc                                                     18


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.7-6

<400>  83
aatgtacagg gcgagtct                                                     18


<210>  84
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.8-1

<400>  84
ccccggcacc tcccgccc                                                     18


<210>  85
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.8-2

<400>  85
cagcctccct ggtccacg                                                     18


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.8-3

<400>  86
cccttcctga ctgtgcgc                                                     18


<210>  87
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.8-4

<400>  87
tgggtgggct gggcggcc                                                     18


<210>  88
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.8-5

<400>  88
ggtgagggca ctaagcaa                                                     18


<210>  89
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.8-6

<400>  89
tgtacagggc gagtctcc                                                     18


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.9-1

<400>  90
ccggcacctc ccgcccca                                                     18


<210>  91
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.9-2

<400>  91
gcctccctgg tccacgcc                                                     18


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.9-3

<400>  92
cttcctgact gtgcgctg                                                     18


<210>  93
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.9-4

<400>  93
ggtgggctgg gcggccgg                                                     18


<210>  94
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.9-5

<400>  94
tgagggcact aagcaatg                                                     18


<210>  95
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-5.9-6

<400>  95
tacagggcga gtctccga                                                     18


