                               SEQUENCE LISTING

<110> DANA-FARBER CANCER INSTITUTE, INC.
 
<120> STRUCTURALLY-STABILIZED AND HDMX-SELECTIVE P53 PEPTIDES AND USES 
      THEREOF

<130> 00530-0355WO1

<140>
<141>

<150> 63/016,130
<151> 2020-04-27

<160> 242   

<170> PatentIn version 3.5

<210> 1
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 1
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 2
Ala Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 3
Leu Ala Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 4
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 4
Leu Ser Ala Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 5
Leu Ser Gln Ala Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 6
Leu Ser Gln Glu Ala Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 7
Leu Ser Gln Glu Thr Ala Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 8
Leu Ser Gln Glu Thr Phe Xaa Ala Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 9
Leu Ser Gln Glu Thr Phe Xaa Asp Ala Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 10
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Ala Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 11
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Ala Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 12
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 12
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Ala Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 13
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Ala Xaa Glu Asn 
1               5                   10                  15      


<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 14
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Ala Asn 
1               5                   10                  15      


<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 15
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Ala 
1               5                   10                  15      


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 16
Arg Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 17
Leu Arg Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 18
Leu Ser Arg Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 19
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 19
Leu Ser Gln Arg Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 20
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 20
Leu Ser Gln Glu Arg Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 21
Leu Ser Gln Glu Thr Arg Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 22
Leu Ser Gln Glu Thr Phe Xaa Arg Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 23
Leu Ser Gln Glu Thr Phe Xaa Asp Arg Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 24
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 24
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Arg Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 25
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Arg Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 26
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 26
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Arg Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 27
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 27
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Arg Xaa Glu Asn 
1               5                   10                  15      


<210> 28
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 28
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Arg Asn 
1               5                   10                  15      


<210> 29
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 29
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Arg 
1               5                   10                  15      


<210> 30
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 30
Glu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 31
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 31
Leu Glu Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 32
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 32
Leu Ser Glu Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 33
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 33
Leu Ser Gln Glu Glu Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 34
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 34
Leu Ser Gln Glu Thr Glu Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 35
Leu Ser Gln Glu Thr Phe Xaa Glu Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 36
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 36
Leu Ser Gln Glu Thr Phe Xaa Asp Glu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 37
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 37
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Glu Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 38
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 38
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 39
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Glu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 40
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Glu Xaa Glu Asn 
1               5                   10                  15      


<210> 41
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 41
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Glu 
1               5                   10                  15      


<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 42
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Arg Xaa Glu Asn 
1               5                   10                  15      


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 43
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Arg Xaa Ala Asn 
1               5                   10                  15      


<210> 44
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 44
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Ala Xaa Glu Asn 
1               5                   10                  15      


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 45
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Glu Xaa Glu Asn 
1               5                   10                  15      


<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 46
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Glu Xaa Ala Asn 
1               5                   10                  15      


<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 47
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Leu Xaa Ala Asn 
1               5                   10                  15      


<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 48
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Glu Leu Ala Xaa Ala Asn 
1               5                   10                  15      


<210> 49
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 49
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Arg Xaa Ala Asn 
1               5                   10                  15      


<210> 50
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 50
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Ala Xaa Ala Asn 
1               5                   10                  15      


<210> 51
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 51
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Glu Xaa Ala Asn 
1               5                   10                  15      


<210> 52
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 52
Leu Ser Gln Glu Thr Phe Xaa Asp Arg Trp Lys Leu Glu Xaa Glu Asn 
1               5                   10                  15      


<210> 53
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 53
Leu Ser Gln Glu Thr Phe Xaa Asp Arg Trp Lys Leu Arg Xaa Glu Asn 
1               5                   10                  15      


<210> 54
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 54
Leu Ser Gln Glu Thr Phe Xaa Asp Arg Trp Lys Leu Ala Xaa Glu Asn 
1               5                   10                  15      


<210> 55
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 55
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 56
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Asp Xaa Ser Ala Ala 
1               5                   10                  


<210> 57
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 57
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Ala Xaa Ser Ala Ala 
1               5                   10                  


<210> 58
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 58
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Arg Xaa Ser Ala Ala 
1               5                   10                  


<210> 59
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 59
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 60
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 60
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Phe Xaa Ser Ala Ala 
1               5                   10                  


<210> 61
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 61
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Gly Xaa Ser Ala Ala 
1               5                   10                  


<210> 62
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 62
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln His Xaa Ser Ala Ala 
1               5                   10                  


<210> 63
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 63
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Ile Xaa Ser Ala Ala 
1               5                   10                  


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 64
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Lys Xaa Ser Ala Ala 
1               5                   10                  


<210> 65
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 65
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Leu Xaa Ser Ala Ala 
1               5                   10                  


<210> 66
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> norleucine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 66
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 67
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 67
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Asn Xaa Ser Ala Ala 
1               5                   10                  


<210> 68
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 68
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Gln Xaa Ser Ala Ala 
1               5                   10                  


<210> 69
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 69
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Ser Xaa Ser Ala Ala 
1               5                   10                  


<210> 70
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 70
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Thr Xaa Ser Ala Ala 
1               5                   10                  


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 71
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Val Xaa Ser Ala Ala 
1               5                   10                  


<210> 72
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 72
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Trp Xaa Ser Ala Ala 
1               5                   10                  


<210> 73
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 73
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Tyr Xaa Ser Ala Ala 
1               5                   10                  


<210> 74
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 74
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Pro Xaa Ser Ala Ala 
1               5                   10                  


<210> 75
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 75
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Cys Xaa Ser Ala Ala 
1               5                   10                  


<210> 76
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> norleucine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 76
Leu Thr Phe Xaa Glu Arg Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 77
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 77
Leu Thr Phe Xaa Glu Tyr Trp Glu Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 78
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> homoglutamic acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 78
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 79
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 79
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ala Ala Ala 
1               5                   10                  


<210> 80
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 80
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 81
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 81
Leu Thr Phe Xaa Glu Tyr Trp Glu Gln Xaa Xaa Glu Ala Ala 
1               5                   10                  


<210> 82
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> methionine-sulfoxide

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 82
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 83
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 83
Leu Thr Phe Xaa Glu Arg Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 84
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<400> 84
Leu Thr Phe Xaa Glu Tyr 
1               5       


<210> 85
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (10)..(10)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 85
Leu Thr Phe Xaa Xaa Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 86
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> 5-fluoronorvaline

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 86
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 87
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 87
Leu Thr Phe Xaa Glu Tyr Trp Arg Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 88
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 88
Leu Thr Phe Xaa Glu Tyr Trp Leu Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 89
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 89
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Glu Xaa Ser Leu Ala 
1               5                   10                  


<210> 90
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 90
Leu Thr Phe Xaa Leu Tyr Trp Ala Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 91
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 91
Leu Thr Phe Xaa Glu Tyr Trp Phe Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 92
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 92
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Glu Xaa Ser Phe Ala 
1               5                   10                  


<210> 93
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 93
Leu Thr Phe Xaa Phe Tyr Trp Ala Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 94
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 94
Leu Thr Phe Xaa Glu Arg Trp Ala Gln Glu Xaa Ser Ala Ala 
1               5                   10                  


<210> 95
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 95
Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Leu Xaa Gln Asn 
1               5                   10                  15      


<210> 96
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 96
Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Glu Xaa Gln Asn 
1               5                   10                  15      


<210> 97
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 97
Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Xaa Xaa Gln Asn 
1               5                   10                  15      


<210> 98
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<400> 98
Gln Ser Gln Xaa Thr Phe Xaa Asn Leu Trp Arg Leu Xaa Xaa Gln Asn 
1               5                   10                  15      


<210> 99
<211> 16
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      p53 transactivation domain"

<400> 99
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 100
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Gln Ser Gln Gln Thr Phe Ser Asn Leu Trp Arg Leu Leu Pro Gln Asn 
1               5                   10                  15      


<210> 101
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<400> 101
Leu Thr Phe Glu Glu Tyr Trp Ala Gln Xaa Thr Ser Ala Ala 
1               5                   10                  


<210> 102
<211> 393
<212> PRT
<213> Homo sapiens

<400> 102
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210> 103
<211> 491
<212> PRT
<213> Homo sapiens

<400> 103
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210> 104
<211> 490
<212> PRT
<213> Homo sapiens

<400> 104
Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Asp Ala Ala Gln Thr Leu Ala Leu Ala Gln Asp His Ser Met 
        115                 120                 125             


Asp Ile Pro Ser Gln Asp Gln Leu Lys Gln Ser Ala Glu Glu Ser Ser 
    130                 135                 140                 


Thr Ser Arg Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr 
145                 150                 155                 160 


Ser Glu His Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu 
                165                 170                 175     


Asn Leu Ala Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu 
            180                 185                 190         


Trp Asp Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser 
        195                 200                 205             


Asn Tyr Thr Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln 
    210                 215                 220                 


Asp Val Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe 
225                 230                 235                 240 


Leu Asn Glu Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu 
                245                 250                 255     


Ala Ala Asp Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp 
            260                 265                 270         


Lys Lys Val Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys 
        275                 280                 285             


Ser Leu Ser Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp 
    290                 295                 300                 


Gln Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys 
305                 310                 315                 320 


Phe Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys 
                325                 330                 335     


Leu Thr His Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys 
            340                 345                 350         


Glu Asn Glu Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala 
        355                 360                 365             


Pro Val Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys 
    370                 375                 380                 


Leu Phe Asp Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser 
385                 390                 395                 400 


Ser Glu Ser Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn 
                405                 410                 415     


Leu Ser Glu Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn 
            420                 425                 430         


Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn 
        435                 440                 445             


Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala 
    450                 455                 460                 


Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu 
465                 470                 475                 480 


Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
                485                 490 


<210> 105
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 105
Leu Ser Glu Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 106
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 106
Leu Ser Gln Ala Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 107
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 107
Leu Ser Gln Glu Thr Ala Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 108
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 108
Leu Ser Gln Glu Thr Phe Ser Ala Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 109
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 109
Leu Ser Gln Glu Thr Phe Ser Asp Arg Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 110
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 110
Leu Ser Gln Glu Thr Phe Ser Asp Leu Ala Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 111
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 111
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Glu Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 112
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 112
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Glu Leu Ala Pro Glu Asn 
1               5                   10                  15      


<210> 113
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 113
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Glu Leu Ala Pro Ala Asn 
1               5                   10                  15      


<210> 114
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 114
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Ala Pro Glu Asn 
1               5                   10                  15      


<210> 115
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 115
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Ala Pro Ala Asn 
1               5                   10                  15      


<210> 116
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 116
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Arg 
1               5                   10                  15      


<210> 117
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Ala" or "Arg" or "Glu" or "Gly" or "His" or "Lys" or
      "Asn" or "Gln" or "Ser" or "Thr" or "Val" or "Trp" or "Tyr" or
      "Pro" or "Cys" or "homoglutamic acid" or "E(OMe)" or 
      "5-fluoronorvaline"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 117
Leu Thr Phe Glu Glu Tyr Trp Ala Gln Asp Thr Ser Ala Ala 
1               5                   10                  


<210> 118
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 118
Leu Thr Phe Glu Glu Tyr 
1               5       


<210> 119
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Leu" or "Phe"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 119
Leu Thr Phe Glu Glu Tyr Trp Arg Gln Glu Thr Ala Ala Ala 
1               5                   10                  


<210> 120
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="Phe"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 120
Leu Thr Phe Glu Glu Tyr Trp Ala Gln Glu Thr Ser Leu Ala 
1               5                   10                  


<210> 121
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Phe"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 121
Leu Thr Phe Glu Leu Tyr Trp Ala Gln Glu Thr Ser Ala Ala 
1               5                   10                  


<210> 122
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 122
Leu Thr Phe Glu Glu Arg Trp Ala Gln Glu Thr Ser Ala Ala 
1               5                   10                  


<210> 123
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="E(OMe)"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 123
Gln Ser Gln Gln Thr Phe Ser Asn Leu Trp Arg Leu Glu Pro Gln Asn 
1               5                   10                  15      


<210> 124
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> E(OMe)

<220>
<221> MOD_RES
<222> (8)..(8)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> E(OMe)

<400> 124
Gln Ser Gln Xaa Thr Phe Ser Xaa Asn Leu Trp Arg Leu Xaa Pro Gln 
1               5                   10                  15      


Asn 
    


<210> 125
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 125
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Glu Leu Leu Pro Ala Asn 
1               5                   10                  15      


<210> 126
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 126
Ala Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 127
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 127
Leu Ala Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 128
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Arg"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 128
Leu Ser Ala Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 129
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 129
Leu Ser Gln Arg Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 130
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 130
Leu Ser Gln Glu Ala Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 131
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 131
Leu Ser Gln Glu Thr Phe Ser Arg Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 132
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 132
Leu Ser Gln Glu Thr Phe Ser Asp Ala Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 133
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="Arg"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 133
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Ala Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 134
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="Arg" or "Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 134
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Ala Leu Pro Glu Asn 
1               5                   10                  15      


<210> 135
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="Arg"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 135
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Ala Asn 
1               5                   10                  15      


<210> 136
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="Glu"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 136
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Ala 
1               5                   10                  15      


<210> 137
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 137
Leu Thr Phe Xaa Glu Tyr Trp Glu Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 138
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Ile" or "Leu" or "norleucine"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 138
Leu Thr Phe Glu Glu Tyr Trp Ala Gln Phe Thr Ser Ala Ala 
1               5                   10                  


<210> 139
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 139
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ala Ala Ala 
1               5                   10                  


<210> 140
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<400> 140
Leu Thr Phe Xaa Glu Tyr Trp Glu Gln Xaa Xaa Glu Ala Ala 
1               5                   10                  


<210> 141

<400> 141
000


<210> 142

<400> 142
000


<210> 143

<400> 143
000


<210> 144
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Phe"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Glu"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Tyr"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="conservative amino acid substitution of Trp"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="charged amino acid" or "hydrophobic amino acid less 
      hydrophobic than alanine" or "hydrophilic amino acid"

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 144
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Ala Xaa Ser Ala Ala 
1               5                   10                  


<210> 145
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="charged amino acid"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Glu"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Tyr"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="conservative amino acid substitution of Trp"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="cyclobutyl alanine"

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 145
Leu Thr Ala Xaa Glu Tyr Trp Ala Gln Leu Xaa Ser Ala Ala 
1               5                   10                  


<210> 146
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Phe"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Glu"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Tyr"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="charged amino acid" or "aromatic amino acid other
      than W"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="cyclobutyl alanine"

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 146
Leu Thr Phe Xaa Glu Tyr Ala Ala Gln Leu Xaa Ser Ala Ala 
1               5                   10                  


<210> 147
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu" or "Gln"
      or "conservative amino acid substitution of Gln" or " "

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Ser" or " "

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Gln" or " "

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="conservative amino acid substitution of Glu" or "Gln" 
      or "conservative amino acid substitution of Gln" or "Leu" or 
      "Ala"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Thr" or "Ala"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Phe" or "Ala"
      or "Arg" or "Glu" or " "

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Glu"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Asp" or "Asn"
      or "conservative amino acid substitution of Asn" or "Glu" or 
      "Ala"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Leu" or "Tyr"
      or "Arg"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="conservative amino acid substitution of Trp" or "Ala"
      or "Arg" or "Glu"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="conservative amino acid substitution of Lys" or "Arg"
      or"conservative amino acid substitution of Arg" or "Ala" or
       "Glu"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Leu" or "Gln"
      or "Lys" or "Ala"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="charged amino acid" or "hydrophobic amino acid less
      hydrophobic than alanine" or "hydrophilic amino acid" or "Arg" 
      or "Glu" or "E(OMe)" or "Met(O)" or "homoglutamic acid" or 
      "5-fluoronorvaline" or "Gly" or "His" or "Lys" or "Asn" or 

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="Gln" or "Ser" or "Thr" or "Val" or "Trp" or "Tyr" or
      "Prp" or "Cys"

<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln" or "Ser" or
      "Ala"

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="conservative amino acid substitution of Asn" or "Ala"
      or " "

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 147
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Ala Pro Glu Asn 
1               5                   10                  15      


<210> 148
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="charged amino acid"

<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Asp" or "Asn"
      or "conservative amino acid substitution of Asn"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="conservative amino acid substitution of Trp"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="conservative amino acid substitution of Lys" or "Arg"
      or "conservative amino acid substitution of Arg"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="conservative amino acid substitution of Asn"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 148
Leu Ser Gln Glu Thr Ala Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 149
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Phe"

<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Asp" or "Asn"
      or "conservative amino acid substitution of Asn"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="charged amino acid" or "aromatic amino acid other 
      than W"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="conservative amino acid substitution of Lys" or "Arg"
      or "conservative amino acid substitution of Arg"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="conservative amino acid substitution of Asn"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 149
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Ala Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 150
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 150
Ala Ser Gln Glu Thr Phe 
1               5       


<210> 151
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 151
Asp Leu Trp Lys Leu Leu 
1               5       


<210> 152
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 152
Leu Ala Gln Glu Thr Phe 
1               5       


<210> 153
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 153
Leu Ser Ala Glu Thr Phe 
1               5       


<210> 154
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 154
Leu Ser Gln Ala Thr Phe 
1               5       


<210> 155
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 155
Leu Ser Gln Glu Ala Phe 
1               5       


<210> 156
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 156
Leu Ser Gln Glu Thr Ala 
1               5       


<210> 157
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 157
Leu Ser Gln Glu Thr Phe 
1               5       


<210> 158
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 158
Ala Leu Trp Lys Leu Leu 
1               5       


<210> 159
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 159
Asp Ala Trp Lys Leu Leu 
1               5       


<210> 160
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 160
Asp Leu Ala Lys Leu Leu 
1               5       


<210> 161
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 161
Asp Leu Trp Ala Leu Leu 
1               5       


<210> 162
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 162
Arg Ser Gln Glu Thr Phe 
1               5       


<210> 163
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 163
Leu Arg Gln Glu Thr Phe 
1               5       


<210> 164
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 164
Leu Ser Arg Glu Thr Phe 
1               5       


<210> 165
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 165
Leu Ser Gln Arg Thr Phe 
1               5       


<210> 166
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 166
Leu Ser Gln Glu Arg Phe 
1               5       


<210> 167
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 167
Leu Ser Gln Glu Thr Arg 
1               5       


<210> 168
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 168
Arg Leu Trp Lys Leu Leu 
1               5       


<210> 169
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 169
Asp Arg Trp Lys Leu Leu 
1               5       


<210> 170
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 170
Asp Leu Arg Lys Leu Leu 
1               5       


<210> 171
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 171
Asp Leu Trp Arg Leu Leu 
1               5       


<210> 172
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 172
Asp Leu Trp Lys Arg Leu 
1               5       


<210> 173
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 173
Asp Leu Trp Lys Leu Arg 
1               5       


<210> 174
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 174
Glu Ser Gln Glu Thr Phe 
1               5       


<210> 175
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 175
Leu Glu Gln Glu Thr Phe 
1               5       


<210> 176
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 176
Leu Ser Glu Glu Thr Phe 
1               5       


<210> 177
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 177
Leu Ser Gln Glu Glu Phe 
1               5       


<210> 178
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 178
Leu Ser Gln Glu Thr Glu 
1               5       


<210> 179
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 179
Glu Leu Trp Lys Leu Leu 
1               5       


<210> 180
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 180
Asp Glu Trp Lys Leu Leu 
1               5       


<210> 181
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 181
Asp Leu Glu Lys Leu Leu 
1               5       


<210> 182
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 182
Asp Leu Trp Glu Leu Leu 
1               5       


<210> 183
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 183
Asp Leu Trp Lys Glu Leu 
1               5       


<210> 184
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 184
Asp Leu Trp Lys Leu Glu 
1               5       


<210> 185
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 185
Asp Leu Trp Glu Leu Arg 
1               5       


<210> 186
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 186
Asp Leu Trp Glu Leu Ala 
1               5       


<210> 187
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 187
Asp Leu Trp Glu Leu Glu 
1               5       


<210> 188
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 188
Asp Arg Trp Lys Leu Glu 
1               5       


<210> 189
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 189
Asp Arg Trp Lys Leu Arg 
1               5       


<210> 190
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 190
Asp Arg Trp Lys Leu Ala 
1               5       


<210> 191
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 191
Glu Tyr Trp Ala Gln Asp 
1               5       


<210> 192
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 192
Glu Tyr Trp Ala Gln Ala 
1               5       


<210> 193
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 193
Glu Tyr Trp Ala Gln Arg 
1               5       


<210> 194
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 194
Glu Tyr Trp Ala Gln Glu 
1               5       


<210> 195
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 195
Glu Tyr Trp Ala Gln Phe 
1               5       


<210> 196
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 196
Glu Tyr Trp Ala Gln Gly 
1               5       


<210> 197
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 197
Glu Tyr Trp Ala Gln His 
1               5       


<210> 198
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 198
Glu Tyr Trp Ala Gln Ile 
1               5       


<210> 199
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 199
Glu Tyr Trp Ala Gln Lys 
1               5       


<210> 200
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 200
Glu Tyr Trp Ala Gln Leu 
1               5       


<210> 201
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> norleucine

<400> 201
Glu Tyr Trp Ala Gln Xaa 
1               5       


<210> 202
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 202
Glu Tyr Trp Ala Gln Asn 
1               5       


<210> 203
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 203
Glu Tyr Trp Ala Gln Gln 
1               5       


<210> 204
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 204
Glu Tyr Trp Ala Gln Ser 
1               5       


<210> 205
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 205
Glu Tyr Trp Ala Gln Thr 
1               5       


<210> 206
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 206
Glu Tyr Trp Ala Gln Val 
1               5       


<210> 207
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 207
Glu Tyr Trp Ala Gln Trp 
1               5       


<210> 208
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 208
Glu Tyr Trp Ala Gln Tyr 
1               5       


<210> 209
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 209
Glu Tyr Trp Ala Gln Pro 
1               5       


<210> 210
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 210
Glu Tyr Trp Ala Gln Cys 
1               5       


<210> 211
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> cyclobutylalanine

<400> 211
Glu Arg Trp Ala Gln Xaa 
1               5       


<210> 212
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> cyclobutylalanine

<400> 212
Glu Tyr Trp Glu Gln Xaa 
1               5       


<210> 213
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> homoglutamic acid

<400> 213
Glu Tyr Trp Ala Gln Xaa 
1               5       


<210> 214
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> cyclobutylalanine

<400> 214
Glu Tyr Trp Ala Gln Xaa 
1               5       


<210> 215
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> cyclobutylalanine

<400> 215
Glu Tyr Trp Glu Gln Xaa 
1               5       


<210> 216
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> cyclobutylalanine

<400> 216
Glu Arg Trp Ala Gln Xaa 
1               5       


<210> 217

<400> 217
000


<210> 218
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> 5-fluoronorvaline

<400> 218
Glu Tyr Trp Ala Gln Xaa 
1               5       


<210> 219
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 219
Glu Tyr Trp Arg Gln Glu 
1               5       


<210> 220
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 220
Glu Tyr Trp Leu Gln Glu 
1               5       


<210> 221
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 221
Leu Tyr Trp Ala Gln Glu 
1               5       


<210> 222
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 222
Glu Tyr Trp Phe Gln Glu 
1               5       


<210> 223
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 223
Phe Tyr Trp Ala Gln Glu 
1               5       


<210> 224
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 224
Glu Arg Trp Ala Gln Glu 
1               5       


<210> 225
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 225
Gln Ser Gln Gln Thr Phe 
1               5       


<210> 226
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 226
Asn Leu Trp Arg Leu Glu 
1               5       


<210> 227
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> methionine-sulfoxide

<400> 227
Glu Tyr Trp Ala Gln Xaa 
1               5       


<210> 228
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> E(OMe)

<400> 228
Glu Tyr Trp Ala Gln Xaa 
1               5       


<210> 229
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 229
agccctctct ttgatatgct aag                                               23


<210> 230
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 230
tgggtctttc acggagaag                                                    19


<210> 231
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 231
aagccctctc gcggatatgc taagaaag                                          28


<210> 232
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 232
gggtctttca cggagaagct ctgacg                                            26


<210> 233
<211> 90
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 233
Leu Pro Gly Glu Gly Thr Gln Val His Pro Arg Ala Pro Leu Leu Gln 
1               5                   10                  15      


Ile Leu Lys Val Ala Gly Ala Gln Glu Glu Val Phe Thr Val Lys Glu 
            20                  25                  30          


Val Met His Tyr Leu Gly Gln Tyr Ile Met Met Lys Gln Leu Tyr Asp 
        35                  40                  45              


Lys Gln Arg Gln His Ile Val His Cys His Asp Asp Pro Leu Gly Glu 
    50                  55                  60                  


Leu Leu Glu Val Gly Ser Phe Ser Val Lys Asn Pro Ser Pro Leu Tyr 
65                  70                  75                  80  


Glu Met Leu Lys Arg Asn Leu Val Ile Leu 
                85                  90  


<210> 234
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 234
Asp Leu Trp Lys Ala Leu 
1               5       


<210> 235
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 235
Asp Leu Trp Lys Leu Ala 
1               5       


<210> 236
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 236
His His His His His His 
1               5       


<210> 237
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> E(OMe)

<400> 237
Asn Leu Trp Arg Leu Xaa 
1               5       


<210> 238
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<400> 238
Ala Gln Glu Xaa Ser Ala Ala 
1               5           


<210> 239
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 239
Ala Gln Glu Thr Ala Ala Ala 
1               5           


<210> 240
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Phe"

<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Asp" or "Asn"
      or "conservative amino acid substitution of Asn"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="conservative amino acid substitution of Trp"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="conservative amino acid substitution of Lys" or "Arg"
      or "conservative amino acid substitution of Arg"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="charged amino acid" or "hydrophobic amino acid less
      hydrophobic than alanine" or "hydrophilic amino acid"

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="conservative amino acid substitution of Asn"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 240
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Ala Xaa Glu Asn 
1               5                   10                  15      


<210> 241
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Phe"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Glu"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Tyr"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="conservative amino acid substitution of Trp"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid except phenylalanine, isoleucine, norleucine,
      and leucine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (13)..(13)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="conservative amino acid substitution of Ala"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 241
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 242
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="conservative amino acid substitution of Leu" or 
      "Gln" or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="conservative amino acid substitution of Ser"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="conservative amino acid substitution of Thr"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="conservative amino acid substitution of Phe"

<220>
<221> MOD_RES
<222> (7)..(7)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="conservative amino acid substitution of Asp" or "Asn"
      or "conservative amino acid substitution of Asn"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="conservative amino acid substitution of Trp"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="conservative amino acid substitution of Lys" or "Arg"
      or "conservative amino acid substitution of Arg"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="conservative amino acid substitution of Leu"

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid except phenylalanine, isoleucine, norleucine,
      and leucine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> stapling amino acid

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="conservative amino acid substitution of Glu" or "Gln"
      or "conservative amino acid substitution of Gln"

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="conservative amino acid substitution of Asn"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 242
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Xaa Xaa Glu Asn 
1               5                   10                  15      


