                               SEQUENCE LISTING

<110> ARUNA BIO, INC.
 
<120> BINDING AGENTS AND USES THEREOF FOR CENTRAL NERVOUS SYSTEM 
      DELIVERY

<130> A106525 1050WO

<140>
<141>

<150> 63/015,936
<151> 2020-04-27

<160> 109   

<170> PatentIn version 3.5

<210> 1
<211> 296
<212> PRT
<213> Homo sapiens

<400> 1
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210> 2
<211> 232
<212> PRT
<213> Homo sapiens

<400> 2
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
    210                 215                 220                 


Gln Asp Leu Gly Pro Val Pro Met 
225                 230         


<210> 3
<211> 160
<212> PRT
<213> Homo sapiens

<400> 3
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Ser His Trp Asn Trp Arg Thr Arg Leu Leu Gly Trp Val 
145                 150                 155                 160 


<210> 4
<211> 211
<212> PRT
<213> Homo sapiens

<400> 4
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Asn Ala 
        115                 120                 125             


Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro Glu Asn 
    130                 135                 140                 


Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys Val Phe 
145                 150                 155                 160 


Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg His Ser 
                165                 170                 175     


Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser Leu Glu Leu 
            180                 185                 190         


Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp Leu Gly Pro 
        195                 200                 205             


Val Pro Met 
    210     


<210> 5
<211> 192
<212> PRT
<213> Homo sapiens

<400> 5
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Ser His Trp Asn Trp Arg Thr Arg Leu Leu Gly Trp Val 
            180                 185                 190         


<210> 6
<211> 250
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Ala Asp His Met Gly 
            20                  25                  30          


Ser Tyr Gly Pro Ala Phe Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Glu Glu Gln Leu Phe Ser Val Asp Leu Lys Lys 
    50                  55                  60                  


Ser Glu Ala Val Trp Arg Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Gly Leu Ala Gly Ile Ala Ala Ile Lys Ala His Leu 
                85                  90                  95      


Asp Ile Leu Val Glu Arg Ser Asn Arg Ser Arg Ala Ile Asn Val Pro 
            100                 105                 110         


Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly Gln Pro 
        115                 120                 125             


Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val Ile Asn 
    130                 135                 140                 


Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val Ala Gln 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe His Tyr 
                165                 170                 175     


Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp Glu Leu Gln Val 
        195                 200                 205             


Pro Ile Pro Pro Pro Asp Ala Met Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ala Ile Gly Leu Val Gly Phe Leu Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Met Gly Thr Tyr Val Ser Ser Val Pro Arg 
                245                 250 


<210> 7
<211> 873
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Ser Thr 
            740                 745                 750         


Ala Thr Thr Val Thr Tyr Ser Glu Thr Lys Asp Thr Asn Thr Thr Glu 
        755                 760                 765             


Ile Ser Ala Thr Ser Gly Leu Val Pro Gly Gly Ile Asn Val Thr Thr 
    770                 775                 780                 


Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp 
785                 790                 795                 800 


Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr 
                805                 810                 815     


Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys Ser Met Asn Phe 
            820                 825                 830         


Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp 
        835                 840                 845             


Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser 
    850                 855                 860                 


Val Val Ser Thr Asp Asp Asp Leu Ala 
865                 870             


<210> 8
<211> 845
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Arg Ile 
            740                 745                 750         


Asn Val Thr Thr Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr 
        755                 760                 765             


Ser Ala Ala Trp Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala 
    770                 775                 780                 


Val Gly Gly Tyr Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys 
785                 790                 795                 800 


Ser Met Asn Phe Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp 
                805                 810                 815     


Leu Ser Ile Asp Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr 
            820                 825                 830         


Pro Ala Ile Ser Val Val Ser Thr Asp Asp Asp Leu Ala 
        835                 840                 845 


<210> 9
<211> 832
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys Arg Asn Ile Thr 
            100                 105                 110         


Cys Ser Pro Asp Glu Phe Thr Cys Ser Ser Gly Arg Cys Ile Ser Arg 
        115                 120                 125             


Asn Phe Val Cys Asn Gly Gln Asp Asp Cys Ser Asp Gly Ser Asp Glu 
    130                 135                 140                 


Leu Asp Cys Ala Pro Pro Thr Cys Gly Ala His Glu Phe Gln Cys Ser 
145                 150                 155                 160 


Thr Ser Ser Cys Ile Pro Ile Ser Trp Val Cys Asp Asp Asp Ala Asp 
                165                 170                 175     


Cys Ser Asp Gln Ser Asp Glu Ser Leu Glu Gln Cys Gly Arg Gln Pro 
            180                 185                 190         


Val Ile His Thr Lys Cys Pro Ala Ser Glu Ile Gln Cys Gly Ser Gly 
        195                 200                 205             


Glu Cys Ile His Lys Lys Trp Arg Cys Asp Gly Asp Pro Asp Cys Lys 
    210                 215                 220                 


Asp Gly Ser Asp Glu Val Asn Cys Pro Ser Arg Thr Cys Arg Pro Asp 
225                 230                 235                 240 


Gln Phe Glu Cys Glu Asp Gly Ser Cys Ile His Gly Ser Arg Gln Cys 
                245                 250                 255     


Asn Gly Ile Arg Asp Cys Val Asp Gly Ser Asp Glu Val Asn Cys Lys 
            260                 265                 270         


Asn Val Asn Gln Cys Leu Gly Pro Gly Lys Phe Lys Cys Arg Ser Gly 
        275                 280                 285             


Glu Cys Ile Asp Ile Ser Lys Val Cys Asn Gln Glu Gln Asp Cys Arg 
    290                 295                 300                 


Asp Trp Ser Asp Glu Pro Leu Lys Glu Cys His Ile Asn Glu Cys Leu 
305                 310                 315                 320 


Val Asn Asn Gly Gly Cys Ser His Ile Cys Lys Asp Leu Val Ile Gly 
                325                 330                 335     


Tyr Glu Cys Asp Cys Ala Ala Gly Phe Glu Leu Ile Asp Arg Lys Thr 
            340                 345                 350         


Cys Gly Asp Ile Asp Glu Cys Gln Asn Pro Gly Ile Cys Ser Gln Ile 
        355                 360                 365             


Cys Ile Asn Leu Lys Gly Gly Tyr Lys Cys Glu Cys Ser Arg Gly Tyr 
    370                 375                 380                 


Gln Met Asp Leu Ala Thr Gly Val Cys Lys Ala Val Gly Lys Glu Pro 
385                 390                 395                 400 


Ser Leu Ile Phe Thr Asn Arg Arg Asp Ile Arg Lys Ile Gly Leu Glu 
                405                 410                 415     


Arg Lys Glu Tyr Ile Gln Leu Val Glu Gln Leu Arg Asn Thr Val Ala 
            420                 425                 430         


Leu Asp Ala Asp Ile Ala Ala Gln Lys Leu Phe Trp Ala Asp Leu Ser 
        435                 440                 445             


Gln Lys Ala Ile Phe Ser Ala Ser Ile Asp Asp Lys Val Gly Arg His 
    450                 455                 460                 


Val Lys Met Ile Asp Asn Val Tyr Asn Pro Ala Ala Ile Ala Val Asp 
465                 470                 475                 480 


Trp Val Tyr Lys Thr Ile Tyr Trp Thr Asp Ala Ala Ser Lys Thr Ile 
                485                 490                 495     


Ser Val Ala Thr Leu Asp Gly Thr Lys Arg Lys Phe Leu Phe Asn Ser 
            500                 505                 510         


Asp Leu Arg Glu Pro Ala Ser Ile Ala Val Asp Pro Leu Ser Gly Phe 
        515                 520                 525             


Val Tyr Trp Ser Asp Trp Gly Glu Pro Ala Lys Ile Glu Lys Ala Gly 
    530                 535                 540                 


Met Asn Gly Phe Asp Arg Arg Pro Leu Val Thr Ala Asp Ile Gln Trp 
545                 550                 555                 560 


Pro Asn Gly Ile Thr Leu Asp Leu Ile Lys Ser Arg Leu Tyr Trp Leu 
                565                 570                 575     


Asp Ser Lys Leu His Met Leu Ser Ser Val Asp Leu Asn Gly Gln Asp 
            580                 585                 590         


Arg Arg Ile Val Leu Lys Ser Leu Glu Phe Leu Ala His Pro Leu Ala 
        595                 600                 605             


Leu Thr Ile Phe Glu Asp Arg Val Tyr Trp Ile Asp Gly Glu Asn Glu 
    610                 615                 620                 


Ala Val Tyr Gly Ala Asn Lys Phe Thr Gly Ser Glu Leu Ala Thr Leu 
625                 630                 635                 640 


Val Asn Asn Leu Asn Asp Ala Gln Asp Ile Ile Val Tyr His Glu Leu 
                645                 650                 655     


Val Gln Pro Ser Gly Lys Asn Trp Cys Glu Glu Asp Met Glu Asn Gly 
            660                 665                 670         


Gly Cys Glu Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn Asp His Ser 
        675                 680                 685             


Pro Lys Tyr Thr Cys Ser Cys Pro Ser Gly Tyr Asn Val Glu Glu Asn 
    690                 695                 700                 


Gly Arg Asp Cys Gln Ser Thr Ala Thr Thr Val Thr Tyr Ser Glu Thr 
705                 710                 715                 720 


Lys Asp Thr Asn Thr Thr Glu Ile Ser Ala Thr Ser Gly Leu Val Pro 
                725                 730                 735     


Gly Gly Ile Asn Val Thr Thr Ala Val Ser Glu Val Ser Val Pro Pro 
            740                 745                 750         


Lys Gly Thr Ser Ala Ala Trp Ala Ile Leu Pro Leu Leu Leu Leu Val 
        755                 760                 765             


Met Ala Ala Val Gly Gly Tyr Leu Met Trp Arg Asn Trp Gln His Lys 
    770                 775                 780                 


Asn Met Lys Ser Met Asn Phe Asp Asn Pro Val Tyr Leu Lys Thr Thr 
785                 790                 795                 800 


Glu Glu Asp Leu Ser Ile Asp Ile Gly Arg His Ser Ala Ser Val Gly 
                805                 810                 815     


His Thr Tyr Pro Ala Ile Ser Val Val Ser Thr Asp Asp Asp Leu Ala 
            820                 825                 830         


<210> 10
<211> 804
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys Arg Asn Ile Thr 
            100                 105                 110         


Cys Ser Pro Asp Glu Phe Thr Cys Ser Ser Gly Arg Cys Ile Ser Arg 
        115                 120                 125             


Asn Phe Val Cys Asn Gly Gln Asp Asp Cys Ser Asp Gly Ser Asp Glu 
    130                 135                 140                 


Leu Asp Cys Ala Pro Pro Thr Cys Gly Ala His Glu Phe Gln Cys Ser 
145                 150                 155                 160 


Thr Ser Ser Cys Ile Pro Ile Ser Trp Val Cys Asp Asp Asp Ala Asp 
                165                 170                 175     


Cys Ser Asp Gln Ser Asp Glu Ser Leu Glu Gln Cys Gly Arg Gln Pro 
            180                 185                 190         


Val Ile His Thr Lys Cys Pro Ala Ser Glu Ile Gln Cys Gly Ser Gly 
        195                 200                 205             


Glu Cys Ile His Lys Lys Trp Arg Cys Asp Gly Asp Pro Asp Cys Lys 
    210                 215                 220                 


Asp Gly Ser Asp Glu Val Asn Cys Pro Ser Arg Thr Cys Arg Pro Asp 
225                 230                 235                 240 


Gln Phe Glu Cys Glu Asp Gly Ser Cys Ile His Gly Ser Arg Gln Cys 
                245                 250                 255     


Asn Gly Ile Arg Asp Cys Val Asp Gly Ser Asp Glu Val Asn Cys Lys 
            260                 265                 270         


Asn Val Asn Gln Cys Leu Gly Pro Gly Lys Phe Lys Cys Arg Ser Gly 
        275                 280                 285             


Glu Cys Ile Asp Ile Ser Lys Val Cys Asn Gln Glu Gln Asp Cys Arg 
    290                 295                 300                 


Asp Trp Ser Asp Glu Pro Leu Lys Glu Cys His Ile Asn Glu Cys Leu 
305                 310                 315                 320 


Val Asn Asn Gly Gly Cys Ser His Ile Cys Lys Asp Leu Val Ile Gly 
                325                 330                 335     


Tyr Glu Cys Asp Cys Ala Ala Gly Phe Glu Leu Ile Asp Arg Lys Thr 
            340                 345                 350         


Cys Gly Asp Ile Asp Glu Cys Gln Asn Pro Gly Ile Cys Ser Gln Ile 
        355                 360                 365             


Cys Ile Asn Leu Lys Gly Gly Tyr Lys Cys Glu Cys Ser Arg Gly Tyr 
    370                 375                 380                 


Gln Met Asp Leu Ala Thr Gly Val Cys Lys Ala Val Gly Lys Glu Pro 
385                 390                 395                 400 


Ser Leu Ile Phe Thr Asn Arg Arg Asp Ile Arg Lys Ile Gly Leu Glu 
                405                 410                 415     


Arg Lys Glu Tyr Ile Gln Leu Val Glu Gln Leu Arg Asn Thr Val Ala 
            420                 425                 430         


Leu Asp Ala Asp Ile Ala Ala Gln Lys Leu Phe Trp Ala Asp Leu Ser 
        435                 440                 445             


Gln Lys Ala Ile Phe Ser Ala Ser Ile Asp Asp Lys Val Gly Arg His 
    450                 455                 460                 


Val Lys Met Ile Asp Asn Val Tyr Asn Pro Ala Ala Ile Ala Val Asp 
465                 470                 475                 480 


Trp Val Tyr Lys Thr Ile Tyr Trp Thr Asp Ala Ala Ser Lys Thr Ile 
                485                 490                 495     


Ser Val Ala Thr Leu Asp Gly Thr Lys Arg Lys Phe Leu Phe Asn Ser 
            500                 505                 510         


Asp Leu Arg Glu Pro Ala Ser Ile Ala Val Asp Pro Leu Ser Gly Phe 
        515                 520                 525             


Val Tyr Trp Ser Asp Trp Gly Glu Pro Ala Lys Ile Glu Lys Ala Gly 
    530                 535                 540                 


Met Asn Gly Phe Asp Arg Arg Pro Leu Val Thr Ala Asp Ile Gln Trp 
545                 550                 555                 560 


Pro Asn Gly Ile Thr Leu Asp Leu Ile Lys Ser Arg Leu Tyr Trp Leu 
                565                 570                 575     


Asp Ser Lys Leu His Met Leu Ser Ser Val Asp Leu Asn Gly Gln Asp 
            580                 585                 590         


Arg Arg Ile Val Leu Lys Ser Leu Glu Phe Leu Ala His Pro Leu Ala 
        595                 600                 605             


Leu Thr Ile Phe Glu Asp Arg Val Tyr Trp Ile Asp Gly Glu Asn Glu 
    610                 615                 620                 


Ala Val Tyr Gly Ala Asn Lys Phe Thr Gly Ser Glu Leu Ala Thr Leu 
625                 630                 635                 640 


Val Asn Asn Leu Asn Asp Ala Gln Asp Ile Ile Val Tyr His Glu Leu 
                645                 650                 655     


Val Gln Pro Ser Gly Lys Asn Trp Cys Glu Glu Asp Met Glu Asn Gly 
            660                 665                 670         


Gly Cys Glu Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn Asp His Ser 
        675                 680                 685             


Pro Lys Tyr Thr Cys Ser Cys Pro Ser Gly Tyr Asn Val Glu Glu Asn 
    690                 695                 700                 


Gly Arg Asp Cys Gln Arg Ile Asn Val Thr Thr Ala Val Ser Glu Val 
705                 710                 715                 720 


Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp Ala Ile Leu Pro Leu 
                725                 730                 735     


Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr Leu Met Trp Arg Asn 
            740                 745                 750         


Trp Gln His Lys Asn Met Lys Ser Met Asn Phe Asp Asn Pro Val Tyr 
        755                 760                 765             


Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp Ile Gly Arg His Ser 
    770                 775                 780                 


Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser Val Val Ser Thr Asp 
785                 790                 795                 800 


Asp Asp Leu Ala 
                


<210> 11
<211> 745
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
1               5                   10                  15      


Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
            20                  25                  30          


Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
        35                  40                  45              


Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
    50                  55                  60                  


Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  


Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         


Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
        115                 120                 125             


His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
    130                 135                 140                 


Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
145                 150                 155                 160 


Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                165                 170                 175     


Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
            180                 185                 190         


Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
        195                 200                 205             


Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
    210                 215                 220                 


Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                245                 250                 255     


Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
            260                 265                 270         


Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
        275                 280                 285             


Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
    290                 295                 300                 


Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                325                 330                 335     


Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
            340                 345                 350         


Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
        355                 360                 365             


Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
    370                 375                 380                 


Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
385                 390                 395                 400 


Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                405                 410                 415     


Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
            420                 425                 430         


Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
        435                 440                 445             


Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys 
    450                 455                 460                 


Cys Ser Tyr Ser Arg Asn Asp Met Leu Leu Asn Ile Asn Val Glu Ser 
465                 470                 475                 480 


Leu Thr Pro Pro Val Ala Ser Val Lys Leu Gly Pro Phe Thr Leu Ile 
                485                 490                 495     


Leu Gln Ser Tyr Pro Asp Asn Ser Tyr Gln Gln Pro Tyr Gly Glu Asn 
            500                 505                 510         


Glu Tyr Pro Leu Val Arg Phe Leu Arg Gln Pro Ile Tyr Met Glu Val 
        515                 520                 525             


Arg Val Leu Asn Arg Asp Asp Pro Asn Ile Lys Leu Val Leu Asp Asp 
    530                 535                 540                 


Cys Trp Ala Thr Ser Thr Met Asp Pro Asp Ser Phe Pro Gln Trp Asn 
545                 550                 555                 560 


Val Val Val Asp Gly Cys Ala Tyr Asp Leu Asp Asn Tyr Gln Thr Thr 
                565                 570                 575     


Phe His Pro Val Gly Ser Ser Val Thr His Pro Asp His Tyr Gln Arg 
            580                 585                 590         


Phe Asp Met Lys Ala Phe Ala Phe Val Ser Glu Ala His Val Leu Ser 
        595                 600                 605             


Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu Ser 
    610                 615                 620                 


Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His 
625                 630                 635                 640 


Arg Arg Ala Thr Gly Ala Thr Glu Ala Glu Lys Met Thr Val Ser Leu 
                645                 650                 655     


Pro Gly Pro Ile Leu Leu Leu Ser Asp Asp Ser Ser Phe Arg Gly Val 
            660                 665                 670         


Gly Ser Ser Asp Leu Lys Ala Ser Gly Ser Ser Gly Glu Lys Ser Arg 
        675                 680                 685             


Ser Glu Thr Gly Glu Glu Val Gly Ser Arg Gly Ala Met Asp Thr Lys 
    690                 695                 700                 


Gly His Lys Thr Ala Gly Asp Val Gly Ser Lys Ala Val Ala Ala Val 
705                 710                 715                 720 


Ala Ala Phe Ala Gly Val Val Ala Thr Leu Gly Phe Ile Tyr Tyr Leu 
                725                 730                 735     


Tyr Glu Lys Arg Thr Val Ser Asn His 
            740                 745 


<210> 12
<211> 736
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
1               5                   10                  15      


Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
            20                  25                  30          


Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
        35                  40                  45              


Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
    50                  55                  60                  


Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  


Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         


Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
        115                 120                 125             


His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
    130                 135                 140                 


Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
145                 150                 155                 160 


Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                165                 170                 175     


Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
            180                 185                 190         


Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
        195                 200                 205             


Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
    210                 215                 220                 


Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                245                 250                 255     


Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
            260                 265                 270         


Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
        275                 280                 285             


Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
    290                 295                 300                 


Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                325                 330                 335     


Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
            340                 345                 350         


Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
        355                 360                 365             


Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
    370                 375                 380                 


Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
385                 390                 395                 400 


Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                405                 410                 415     


Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
            420                 425                 430         


Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
        435                 440                 445             


Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Asn Asp Met Leu 
    450                 455                 460                 


Leu Asn Ile Asn Val Glu Ser Leu Thr Pro Pro Val Ala Ser Val Lys 
465                 470                 475                 480 


Leu Gly Pro Phe Thr Leu Ile Leu Gln Ser Tyr Pro Asp Asn Ser Tyr 
                485                 490                 495     


Gln Gln Pro Tyr Gly Glu Asn Glu Tyr Pro Leu Val Arg Phe Leu Arg 
            500                 505                 510         


Gln Pro Ile Tyr Met Glu Val Arg Val Leu Asn Arg Asp Asp Pro Asn 
        515                 520                 525             


Ile Lys Leu Val Leu Asp Asp Cys Trp Ala Thr Ser Thr Met Asp Pro 
    530                 535                 540                 


Asp Ser Phe Pro Gln Trp Asn Val Val Val Asp Gly Cys Ala Tyr Asp 
545                 550                 555                 560 


Leu Asp Asn Tyr Gln Thr Thr Phe His Pro Val Gly Ser Ser Val Thr 
                565                 570                 575     


His Pro Asp His Tyr Gln Arg Phe Asp Met Lys Ala Phe Ala Phe Val 
            580                 585                 590         


Ser Glu Ala His Val Leu Ser Ser Leu Val Tyr Phe His Cys Ser Ala 
        595                 600                 605             


Leu Ile Cys Asn Arg Leu Ser Pro Asp Ser Pro Leu Cys Ser Val Thr 
    610                 615                 620                 


Cys Pro Val Ser Ser Arg His Arg Arg Ala Thr Gly Ala Thr Glu Ala 
625                 630                 635                 640 


Glu Lys Met Thr Val Ser Leu Pro Gly Pro Ile Leu Leu Leu Ser Asp 
                645                 650                 655     


Asp Ser Ser Phe Arg Gly Val Gly Ser Ser Asp Leu Lys Ala Ser Gly 
            660                 665                 670         


Ser Ser Gly Glu Lys Ser Arg Ser Glu Thr Gly Glu Glu Val Gly Ser 
        675                 680                 685             


Arg Gly Ala Met Asp Thr Lys Gly His Lys Thr Ala Gly Asp Val Gly 
    690                 695                 700                 


Ser Lys Ala Val Ala Ala Val Ala Ala Phe Ala Gly Val Val Ala Thr 
705                 710                 715                 720 


Leu Gly Phe Ile Tyr Tyr Leu Tyr Glu Lys Arg Thr Val Ser Asn His 
                725                 730                 735     


<210> 13
<211> 756
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
1               5                   10                  15      


Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
            20                  25                  30          


Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
        35                  40                  45              


Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
    50                  55                  60                  


Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  


Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         


Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
        115                 120                 125             


His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
    130                 135                 140                 


Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
145                 150                 155                 160 


Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                165                 170                 175     


Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
            180                 185                 190         


Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
        195                 200                 205             


Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
    210                 215                 220                 


Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                245                 250                 255     


Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
            260                 265                 270         


Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
        275                 280                 285             


Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
    290                 295                 300                 


Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                325                 330                 335     


Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
            340                 345                 350         


Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
        355                 360                 365             


Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
    370                 375                 380                 


Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
385                 390                 395                 400 


Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                405                 410                 415     


Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
            420                 425                 430         


Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
        435                 440                 445             


Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys 
    450                 455                 460                 


Cys Ser Tyr Ser Arg Asn Asp Met Leu Leu Asn Ile Asn Val Glu Ser 
465                 470                 475                 480 


Leu Thr Pro Pro Val Ala Ser Val Lys Leu Gly Pro Phe Thr Leu Ile 
                485                 490                 495     


Leu Gln Ser Tyr Pro Asp Asn Ser Tyr Gln Gln Pro Tyr Gly Glu Asn 
            500                 505                 510         


Glu Tyr Pro Leu Val Arg Phe Leu Arg Gln Pro Ile Tyr Met Glu Val 
        515                 520                 525             


Arg Val Leu Asn Arg Asp Asp Pro Asn Ile Lys Leu Val Leu Asp Asp 
    530                 535                 540                 


Cys Trp Ala Thr Ser Thr Met Asp Pro Asp Ser Phe Pro Gln Trp Asn 
545                 550                 555                 560 


Val Val Val Asp Gly Cys Ala Tyr Asp Leu Asp Asn Tyr Gln Thr Thr 
                565                 570                 575     


Phe His Pro Val Gly Ser Ser Val Thr His Pro Asp His Tyr Gln Arg 
            580                 585                 590         


Phe Asp Met Lys Ala Phe Ala Phe Val Ser Glu Ala His Val Leu Ser 
        595                 600                 605             


Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu Ser 
    610                 615                 620                 


Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His 
625                 630                 635                 640 


Arg Arg Glu Ala Lys His Lys Leu Asp His Leu Ser Pro Ala Thr Gly 
                645                 650                 655     


Ala Thr Glu Ala Glu Lys Met Thr Val Ser Leu Pro Gly Pro Ile Leu 
            660                 665                 670         


Leu Leu Ser Asp Asp Ser Ser Phe Arg Gly Val Gly Ser Ser Asp Leu 
        675                 680                 685             


Lys Ala Ser Gly Ser Ser Gly Glu Lys Ser Arg Ser Glu Thr Gly Glu 
    690                 695                 700                 


Glu Val Gly Ser Arg Gly Ala Met Asp Thr Lys Gly His Lys Thr Ala 
705                 710                 715                 720 


Gly Asp Val Gly Ser Lys Ala Val Ala Ala Val Ala Ala Phe Ala Gly 
                725                 730                 735     


Val Val Ala Thr Leu Gly Phe Ile Tyr Tyr Leu Tyr Glu Lys Arg Thr 
            740                 745                 750         


Val Ser Asn His 
        755     


<210> 14
<211> 520
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser Gly His 
            260                 265                 270         


Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser Val Asn 
        275                 280                 285             


Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr Arg Gly Val Arg Pro 
    290                 295                 300                 


Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys 
305                 310                 315                 320 


Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp 
                325                 330                 335     


Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln 
            340                 345                 350         


Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val Asp Ser Gly 
        355                 360                 365             


Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser Ala Trp Asp 
    370                 375                 380                 


Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser Trp Asp Arg 
385                 390                 395                 400 


Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro 
                405                 410                 415     


Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys 
            420                 425                 430         


Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp 
        435                 440                 445             


Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val Pro Gly Gly 
    450                 455                 460                 


Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala 
                485                 490                 495     


Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg 
            500                 505                 510         


Thr Leu Gly His Tyr Met Ala Arg 
        515                 520 


<210> 15
<211> 491
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Glu Leu Thr Arg Gly 
            260                 265                 270         


Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg 
        275                 280                 285             


Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp 
    290                 295                 300                 


Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe 
305                 310                 315                 320 


Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val 
                325                 330                 335     


Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser 
            340                 345                 350         


Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser 
        355                 360                 365             


Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly 
    370                 375                 380                 


Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu 
385                 390                 395                 400 


Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu 
                405                 410                 415     


Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val 
            420                 425                 430         


Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu 
        435                 440                 445             


Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp 
    450                 455                 460                 


Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp 
465                 470                 475                 480 


Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
                485                 490     


<210> 16
<211> 244
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Gly 
    210                 215                 220                 


Leu Phe Trp Thr His Thr Pro Cys Gly Asn Leu Ser Ala Gln Gln Thr 
225                 230                 235                 240 


Arg Val Arg Glu 
                


<210> 17
<211> 440
<212> PRT
<213> Homo sapiens

<400> 17
Met Val Pro Glu Pro Gly Pro Thr Ala Asn Ser Thr Pro Ala Trp Gly 
1               5                   10                  15      


Ala Gly Pro Pro Ser Ala Pro Gly Gly Ser Gly Trp Val Ala Ala Ala 
            20                  25                  30          


Leu Cys Val Val Ile Ala Leu Thr Ala Ala Ala Asn Ser Leu Leu Ile 
        35                  40                  45              


Ala Leu Ile Cys Thr Gln Pro Ala Leu Arg Asn Thr Ser Asn Phe Phe 
    50                  55                  60                  


Leu Val Ser Leu Phe Thr Ser Asp Leu Met Val Gly Leu Val Val Met 
65                  70                  75                  80  


Pro Pro Ala Met Leu Asn Ala Leu Tyr Gly Arg Trp Val Leu Ala Arg 
                85                  90                  95      


Gly Leu Cys Leu Leu Trp Thr Ala Phe Asp Val Met Cys Cys Ser Ala 
            100                 105                 110         


Ser Ile Leu Asn Leu Cys Leu Ile Ser Leu Asp Arg Tyr Leu Leu Ile 
        115                 120                 125             


Leu Ser Pro Leu Arg Tyr Lys Leu Arg Met Thr Pro Leu Arg Ala Leu 
    130                 135                 140                 


Ala Leu Val Leu Gly Ala Trp Ser Leu Ala Ala Leu Ala Ser Phe Leu 
145                 150                 155                 160 


Pro Leu Leu Leu Gly Trp His Glu Leu Gly His Ala Arg Pro Pro Val 
                165                 170                 175     


Pro Gly Gln Cys Arg Leu Leu Ala Ser Leu Pro Phe Val Leu Val Ala 
            180                 185                 190         


Ser Gly Leu Thr Phe Phe Leu Pro Ser Gly Ala Ile Cys Phe Thr Tyr 
        195                 200                 205             


Cys Arg Ile Leu Leu Ala Ala Arg Lys Gln Ala Val Gln Val Ala Ser 
    210                 215                 220                 


Leu Thr Thr Gly Met Ala Ser Gln Ala Ser Glu Thr Leu Gln Val Pro 
225                 230                 235                 240 


Arg Thr Pro Arg Pro Gly Val Glu Ser Ala Asp Ser Arg Arg Leu Ala 
                245                 250                 255     


Thr Lys His Ser Arg Lys Ala Leu Lys Ala Ser Leu Thr Leu Gly Ile 
            260                 265                 270         


Leu Leu Gly Met Phe Phe Val Thr Trp Leu Pro Phe Phe Val Ala Asn 
        275                 280                 285             


Ile Val Gln Ala Val Cys Asp Cys Ile Ser Pro Gly Leu Phe Asp Val 
    290                 295                 300                 


Leu Thr Trp Leu Gly Tyr Cys Asn Ser Thr Met Asn Pro Ile Ile Tyr 
305                 310                 315                 320 


Pro Leu Phe Met Arg Asp Phe Lys Arg Ala Leu Gly Arg Phe Leu Pro 
                325                 330                 335     


Cys Pro Arg Cys Pro Arg Glu Arg Gln Ala Ser Leu Ala Ser Pro Ser 
            340                 345                 350         


Leu Arg Thr Ser His Ser Gly Pro Arg Pro Gly Leu Ser Leu Gln Gln 
        355                 360                 365             


Val Leu Pro Leu Pro Leu Pro Pro Asp Ser Asp Ser Asp Ser Asp Ala 
    370                 375                 380                 


Gly Ser Gly Gly Ser Ser Gly Leu Arg Leu Thr Ala Gln Leu Leu Leu 
385                 390                 395                 400 


Pro Gly Glu Ala Thr Gln Asp Pro Pro Leu Pro Thr Arg Ala Ala Ala 
                405                 410                 415     


Ala Val Asn Phe Phe Asn Ile Asp Pro Ala Glu Pro Glu Leu Arg Pro 
            420                 425                 430         


His Pro Leu Gly Ile Pro Thr Asn 
        435                 440 


<210> 18
<211> 481
<212> PRT
<213> Homo sapiens

<400> 18
Met Arg Trp Leu Trp Pro Leu Ala Val Ser Leu Ala Val Ile Leu Ala 
1               5                   10                  15      


Val Gly Leu Ser Arg Val Ser Gly Gly Ala Pro Leu His Leu Gly Arg 
            20                  25                  30          


His Arg Ala Glu Thr Gln Glu Gln Gln Ser Arg Ser Lys Arg Gly Thr 
        35                  40                  45              


Glu Asp Glu Glu Ala Lys Gly Val Gln Gln Tyr Val Pro Glu Glu Trp 
    50                  55                  60                  


Ala Glu Tyr Pro Arg Pro Ile His Pro Ala Gly Leu Gln Pro Thr Lys 
65                  70                  75                  80  


Pro Leu Val Ala Thr Ser Pro Asn Pro Gly Lys Asp Gly Gly Thr Pro 
                85                  90                  95      


Asp Ser Gly Gln Glu Leu Arg Gly Asn Leu Thr Gly Ala Pro Gly Gln 
            100                 105                 110         


Arg Leu Gln Ile Gln Asn Pro Leu Tyr Pro Val Thr Glu Ser Ser Tyr 
        115                 120                 125             


Ser Ala Tyr Ala Ile Met Leu Leu Ala Leu Val Val Phe Ala Val Gly 
    130                 135                 140                 


Ile Val Gly Asn Leu Ser Val Met Cys Ile Val Trp His Ser Tyr Tyr 
145                 150                 155                 160 


Leu Lys Ser Ala Trp Asn Ser Ile Leu Ala Ser Leu Ala Leu Trp Asp 
                165                 170                 175     


Phe Leu Val Leu Phe Phe Cys Leu Pro Ile Val Ile Phe Asn Glu Ile 
            180                 185                 190         


Thr Lys Gln Arg Leu Leu Gly Asp Val Ser Cys Arg Ala Val Pro Phe 
        195                 200                 205             


Met Glu Val Ser Ser Leu Gly Val Thr Thr Phe Ser Leu Cys Ala Leu 
    210                 215                 220                 


Gly Ile Asp Arg Phe His Val Ala Thr Ser Thr Leu Pro Lys Val Arg 
225                 230                 235                 240 


Pro Ile Glu Arg Cys Gln Ser Ile Leu Ala Lys Leu Ala Val Ile Trp 
                245                 250                 255     


Val Gly Ser Met Thr Leu Ala Val Pro Glu Leu Leu Leu Trp Gln Leu 
            260                 265                 270         


Ala Gln Glu Pro Ala Pro Thr Met Gly Thr Leu Asp Ser Cys Ile Met 
        275                 280                 285             


Lys Pro Ser Ala Ser Leu Pro Glu Ser Leu Tyr Ser Leu Val Met Thr 
    290                 295                 300                 


Tyr Gln Asn Ala Arg Met Trp Trp Tyr Phe Gly Cys Tyr Phe Cys Leu 
305                 310                 315                 320 


Pro Ile Leu Phe Thr Val Thr Cys Gln Leu Val Thr Trp Arg Val Arg 
                325                 330                 335     


Gly Pro Pro Gly Arg Lys Ser Glu Cys Arg Ala Ser Lys His Glu Gln 
            340                 345                 350         


Cys Glu Ser Gln Leu Asn Ser Thr Val Val Gly Leu Thr Val Val Tyr 
        355                 360                 365             


Ala Phe Cys Thr Leu Pro Glu Asn Val Cys Asn Ile Val Val Ala Tyr 
    370                 375                 380                 


Leu Ser Thr Glu Leu Thr Arg Gln Thr Leu Asp Leu Leu Gly Leu Ile 
385                 390                 395                 400 


Asn Gln Phe Ser Thr Phe Phe Lys Gly Ala Ile Thr Pro Val Leu Leu 
                405                 410                 415     


Leu Cys Ile Cys Arg Pro Leu Gly Gln Ala Phe Leu Asp Cys Cys Cys 
            420                 425                 430         


Cys Cys Cys Cys Glu Glu Cys Gly Gly Ala Ser Glu Ala Ser Ala Ala 
        435                 440                 445             


Asn Gly Ser Asp Asn Lys Leu Lys Thr Glu Val Ser Ser Ser Ile Tyr 
    450                 455                 460                 


Phe His Lys Pro Arg Glu Ser Pro Pro Leu Leu Pro Leu Gly Thr Pro 
465                 470                 475                 480 


Cys 
    


<210> 19
<211> 340
<212> PRT
<213> Homo sapiens

<400> 19
Met Asn Pro Phe His Ala Ser Cys Trp Asn Thr Ser Ala Glu Leu Leu 
1               5                   10                  15      


Asn Lys Ser Trp Asn Lys Glu Phe Ala Tyr Gln Thr Ala Ser Val Val 
            20                  25                  30          


Asp Thr Val Ile Leu Pro Ser Met Ile Gly Ile Ile Cys Ser Thr Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Ile Val Phe Thr Ile Ile Arg Ser Arg Lys 
    50                  55                  60                  


Lys Thr Val Pro Asp Ile Tyr Ile Cys Asn Leu Ala Val Ala Asp Leu 
65                  70                  75                  80  


Val His Ile Val Gly Met Pro Phe Leu Ile His Gln Trp Ala Arg Gly 
                85                  90                  95      


Gly Glu Trp Val Phe Gly Gly Pro Leu Cys Thr Ile Ile Thr Ser Leu 
            100                 105                 110         


Asp Thr Cys Asn Gln Phe Ala Cys Ser Ala Ile Met Thr Val Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Leu Val Gln Pro Phe Arg Leu Thr Arg Trp 
    130                 135                 140                 


Arg Thr Arg Tyr Lys Thr Ile Arg Ile Asn Leu Gly Leu Trp Ala Ala 
145                 150                 155                 160 


Ser Phe Ile Leu Ala Leu Pro Val Trp Val Tyr Ser Lys Val Ile Lys 
                165                 170                 175     


Phe Lys Asp Gly Val Glu Ser Cys Ala Phe Asp Leu Thr Ser Pro Asp 
            180                 185                 190         


Asp Val Leu Trp Tyr Thr Leu Tyr Leu Thr Ile Thr Thr Phe Phe Phe 
        195                 200                 205             


Pro Leu Pro Leu Ile Leu Val Cys Tyr Ile Leu Ile Leu Cys Tyr Thr 
    210                 215                 220                 


Trp Glu Met Tyr Gln Gln Asn Lys Asp Ala Arg Cys Cys Asn Pro Ser 
225                 230                 235                 240 


Val Pro Lys Gln Arg Val Met Lys Leu Thr Lys Met Val Leu Val Leu 
                245                 250                 255     


Val Val Val Phe Ile Leu Ser Ala Ala Pro Tyr His Val Ile Gln Leu 
            260                 265                 270         


Val Asn Leu Gln Met Glu Gln Pro Thr Leu Ala Phe Tyr Val Gly Tyr 
        275                 280                 285             


Tyr Leu Ser Ile Cys Leu Ser Tyr Ala Ser Ser Ser Ile Asn Pro Phe 
    290                 295                 300                 


Leu Tyr Ile Leu Leu Ser Gly Asn Phe Gln Lys Arg Leu Pro Gln Ile 
305                 310                 315                 320 


Gln Arg Arg Ala Thr Glu Lys Glu Ile Asn Asn Met Gly Asn Thr Leu 
                325                 330                 335     


Lys Ser His Phe 
            340 


<210> 20
<211> 334
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Lys Arg Arg Asp Ile Leu Ala Ile Val Leu Ile Val Leu Pro 
1               5                   10                  15      


Trp Thr Leu Leu Ile Thr Val Trp His Gln Ser Thr Leu Ala Pro Leu 
            20                  25                  30          


Leu Ala Val His Lys Asp Glu Gly Ser Asp Pro Arg Arg Glu Thr Pro 
        35                  40                  45              


Pro Gly Ala Asp Pro Arg Glu Tyr Cys Thr Ser Asp Arg Asp Ile Val 
    50                  55                  60                  


Glu Val Val Arg Thr Glu Tyr Val Tyr Thr Arg Pro Pro Pro Trp Ser 
65                  70                  75                  80  


Asp Thr Leu Pro Thr Ile His Val Val Thr Pro Thr Tyr Ser Arg Pro 
                85                  90                  95      


Val Gln Lys Ala Glu Leu Thr Arg Met Ala Asn Thr Leu Leu His Val 
            100                 105                 110         


Pro Asn Leu His Trp Leu Val Val Glu Asp Ala Pro Arg Arg Thr Pro 
        115                 120                 125             


Leu Thr Ala Arg Leu Leu Arg Asp Thr Gly Leu Asn Tyr Thr His Leu 
    130                 135                 140                 


His Val Glu Thr Pro Arg Asn Tyr Lys Leu Arg Gly Asp Ala Arg Asp 
145                 150                 155                 160 


Pro Arg Ile Pro Arg Gly Thr Met Gln Arg Asn Leu Ala Leu Arg Trp 
                165                 170                 175     


Leu Arg Glu Thr Phe Pro Arg Asn Ser Ser Gln Pro Gly Val Val Tyr 
            180                 185                 190         


Phe Ala Asp Asp Asp Asn Thr Tyr Ser Leu Glu Leu Phe Glu Glu Met 
        195                 200                 205             


Arg Ser Thr Arg Arg Val Ser Val Trp Pro Val Ala Phe Val Gly Gly 
    210                 215                 220                 


Leu Arg Tyr Glu Ala Pro Arg Val Asn Gly Ala Gly Lys Val Val Gly 
225                 230                 235                 240 


Trp Lys Thr Val Phe Asp Pro His Arg Pro Phe Ala Ile Asp Met Ala 
                245                 250                 255     


Gly Phe Ala Val Asn Leu Arg Leu Ile Leu Gln Arg Ser Gln Ala Tyr 
            260                 265                 270         


Phe Lys Leu Arg Gly Val Lys Gly Gly Tyr Gln Glu Ser Ser Leu Leu 
        275                 280                 285             


Arg Glu Leu Val Thr Leu Asn Asp Leu Glu Pro Lys Ala Ala Asn Cys 
    290                 295                 300                 


Thr Lys Ile Leu Val Trp His Thr Arg Thr Glu Lys Pro Val Leu Val 
305                 310                 315                 320 


Asn Glu Gly Lys Lys Gly Phe Thr Asp Pro Ser Val Glu Ile 
                325                 330                 


<210> 21
<211> 347
<212> PRT
<213> Homo sapiens

<400> 21
Met Gly Asn Glu Glu Pro Trp Val Gln Pro Ala Leu Glu Met Pro Lys 
1               5                   10                  15      


Arg Arg Asp Ile Leu Ala Ile Val Leu Ile Val Leu Pro Trp Thr Leu 
            20                  25                  30          


Leu Ile Thr Val Trp His Gln Ser Thr Leu Ala Pro Leu Leu Ala Val 
        35                  40                  45              


His Lys Asp Glu Gly Ser Asp Pro Arg Arg Glu Thr Pro Pro Gly Ala 
    50                  55                  60                  


Asp Pro Arg Glu Tyr Cys Thr Ser Asp Arg Asp Ile Val Glu Val Val 
65                  70                  75                  80  


Arg Thr Glu Tyr Val Tyr Thr Arg Pro Pro Pro Trp Ser Asp Thr Leu 
                85                  90                  95      


Pro Thr Ile His Val Val Thr Pro Thr Tyr Ser Arg Pro Val Gln Lys 
            100                 105                 110         


Ala Glu Leu Thr Arg Met Ala Asn Thr Leu Leu His Val Pro Asn Leu 
        115                 120                 125             


His Trp Leu Val Val Glu Asp Ala Pro Arg Arg Thr Pro Leu Thr Ala 
    130                 135                 140                 


Arg Leu Leu Arg Asp Thr Gly Leu Asn Tyr Thr His Leu His Val Glu 
145                 150                 155                 160 


Thr Pro Arg Asn Tyr Lys Leu Arg Gly Asp Ala Arg Asp Pro Arg Ile 
                165                 170                 175     


Pro Arg Gly Thr Met Gln Arg Asn Leu Ala Leu Arg Trp Leu Arg Glu 
            180                 185                 190         


Thr Phe Pro Arg Asn Ser Ser Gln Pro Gly Val Val Tyr Phe Ala Asp 
        195                 200                 205             


Asp Asp Asn Thr Tyr Ser Leu Glu Leu Phe Glu Glu Met Arg Ser Thr 
    210                 215                 220                 


Arg Arg Val Ser Val Trp Pro Val Ala Phe Val Gly Gly Leu Arg Tyr 
225                 230                 235                 240 


Glu Ala Pro Arg Val Asn Gly Ala Gly Lys Val Val Gly Trp Lys Thr 
                245                 250                 255     


Val Phe Asp Pro His Arg Pro Phe Ala Ile Asp Met Ala Gly Phe Ala 
            260                 265                 270         


Val Asn Leu Arg Leu Ile Leu Gln Arg Ser Gln Ala Tyr Phe Lys Leu 
        275                 280                 285             


Arg Gly Val Lys Gly Gly Tyr Gln Glu Ser Ser Leu Leu Arg Glu Leu 
    290                 295                 300                 


Val Thr Leu Asn Asp Leu Glu Pro Lys Ala Ala Asn Cys Thr Lys Ile 
305                 310                 315                 320 


Leu Val Trp His Thr Arg Thr Glu Lys Pro Val Leu Val Asn Glu Gly 
                325                 330                 335     


Lys Lys Gly Phe Thr Asp Pro Ser Val Glu Ile 
            340                 345         


<210> 22
<211> 380
<212> PRT
<213> Homo sapiens

<400> 22
Met Arg Asn Cys Lys Met Ala Arg Val Ala Ser Val Leu Gly Leu Val 
1               5                   10                  15      


Met Leu Ser Val Ala Leu Leu Ile Leu Ser Leu Ile Ser Tyr Val Ser 
            20                  25                  30          


Leu Lys Lys Glu Asn Ile Phe Thr Thr Pro Lys Tyr Ala Ser Pro Gly 
        35                  40                  45              


Ala Pro Arg Met Tyr Met Phe His Ala Gly Phe Arg Ser Gln Phe Ala 
    50                  55                  60                  


Leu Lys Phe Leu Asp Pro Ser Phe Val Pro Ile Thr Asn Ser Leu Thr 
65                  70                  75                  80  


Gln Glu Leu Gln Glu Lys Pro Ser Lys Trp Lys Phe Asn Arg Thr Ala 
                85                  90                  95      


Phe Leu His Gln Arg Gln Glu Ile Leu Gln His Val Asp Val Ile Lys 
            100                 105                 110         


Asn Phe Ser Leu Thr Lys Asn Ser Val Arg Ile Gly Gln Leu Met His 
        115                 120                 125             


Tyr Asp Tyr Ser Ser His Lys Tyr Val Phe Ser Ile Ser Asn Asn Phe 
    130                 135                 140                 


Arg Ser Leu Leu Pro Asp Val Ser Pro Ile Met Asn Lys His Tyr Asn 
145                 150                 155                 160 


Ile Cys Ala Val Val Gly Asn Ser Gly Ile Leu Thr Gly Ser Gln Cys 
                165                 170                 175     


Gly Gln Glu Ile Asp Lys Ser Asp Phe Val Phe Arg Cys Asn Phe Ala 
            180                 185                 190         


Pro Thr Glu Ala Phe Gln Arg Asp Val Gly Arg Lys Thr Asn Leu Thr 
        195                 200                 205             


Thr Phe Asn Pro Ser Ile Leu Glu Lys Tyr Tyr Asn Asn Leu Leu Thr 
    210                 215                 220                 


Ile Gln Asp Arg Asn Asn Phe Phe Leu Ser Leu Lys Lys Leu Asp Gly 
225                 230                 235                 240 


Ala Ile Leu Trp Ile Pro Ala Phe Phe Phe His Thr Ser Ala Thr Val 
                245                 250                 255     


Thr Arg Thr Leu Val Asp Phe Phe Val Glu His Arg Gly Gln Leu Lys 
            260                 265                 270         


Val Gln Leu Ala Trp Pro Gly Asn Ile Met Gln His Val Asn Arg Tyr 
        275                 280                 285             


Trp Lys Asn Lys His Leu Ser Pro Lys Arg Leu Ser Thr Gly Ile Leu 
    290                 295                 300                 


Met Tyr Thr Leu Ala Ser Ala Ile Cys Glu Glu Ile His Leu Tyr Gly 
305                 310                 315                 320 


Phe Trp Pro Phe Gly Phe Asp Pro Asn Thr Arg Glu Asp Leu Pro Tyr 
                325                 330                 335     


His Tyr Tyr Asp Lys Lys Gly Thr Lys Phe Thr Thr Lys Trp Gln Glu 
            340                 345                 350         


Ser His Gln Leu Pro Ala Glu Phe Gln Leu Leu Tyr Arg Met His Gly 
        355                 360                 365             


Glu Gly Leu Thr Lys Leu Thr Leu Ser His Cys Ala 
    370                 375                 380 


<210> 23
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210> 24
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210> 25
<211> 296
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210> 26
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Ala Pro Trp Leu Gln Leu Leu Ser Leu Leu Gly Leu Leu Pro Gly 
1               5                   10                  15      


Ala Val Ala Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp 
            20                  25                  30          


Gly Pro Pro Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu 
        35                  40                  45              


Met Phe Asn Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu 
    50                  55                  60                  


Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu 
65                  70                  75                  80  


Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg 
                85                  90                  95      


Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp 
            100                 105                 110         


Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp 
        115                 120                 125             


Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly 
    130                 135                 140                 


Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn 
145                 150                 155                 160 


Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser 
                165                 170                 175     


Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile 
            180                 185                 190         


Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu 
        195                 200                 205             


Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu 
    210                 215                 220                 


Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr 
225                 230                 235                 240 


Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu 
                245                 250                 255     


Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro 
            260                 265                 270         


Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp 
        275                 280                 285             


Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val 
    290                 295                 300                 


Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu 
305                 310                 315                 320 


Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly 
                325                 330                 335     


Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu 
            340                 345                 350         


Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe 
        355                 360                 365             


Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser 
    370                 375                 380                 


Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile 
385                 390                 395                 400 


Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile 
                405                 410                 415     


Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala 
            420                 425                 430         


Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala 
        435                 440                 445             


Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr 
    450                 455                 460                 


Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser 
465                 470                 475                 480 


Ala Val Val Asp 
                


<210> 27
<211> 333
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210> 28
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210> 29
<211> 1308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210> 30
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210> 31
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210> 32
<211> 255
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Ala 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Phe Tyr Gln Ser His Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Thr 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Met Phe Ser Lys Phe Ile Ser Phe 
65                  70                  75                  80  


Asp Pro Gln Ser Ala Leu Arg Asn Met Ala Val Gly Lys His Thr Leu 
                85                  90                  95      


Glu Phe Met Met Arg Gln Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Leu Leu 
                245                 250                 255 


<210> 33
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210> 34
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Ser Trp Lys Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala 
1               5                   10                  15      


Ala Val Thr Val Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala 
            20                  25                  30          


Arg Asp Phe Pro Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln 
65                  70                  75                  80  


Ala Val Thr Glu Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys 
                85                  90                  95      


Asp Phe Leu Glu Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His 
            100                 105                 110         


Asn Tyr Glu Ala Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro 
        115                 120                 125             


Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val 
145                 150                 155                 160 


Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr 
                165                 170                 175     


Ser Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu 
            180                 185                 190         


Glu Ile Thr Pro Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His 
        195                 200                 205             


Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu 
    210                 215                 220                 


Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly 
225                 230                 235                 240 


Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg His Arg Gly Gln Lys 
                245                 250                 255     


Gly Pro Arg Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265             


<210> 35
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210> 36
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210> 37
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210> 38
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210> 39
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Thr 
        35                  40                  45              


Asn Ile Ala Arg Thr Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Thr Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Thr Gly Ala 
        115                 120                 125             


Leu Lys Thr Phe Ile Thr Gln Gln Gly Ile Lys Ser Gln His Gln Thr 
    130                 135                 140                 


Lys Glu Glu Gln Ser Gln Ile Thr Ser Gln Val Thr Gly Gln Ile Gly 
145                 150                 155                 160 


Trp Arg Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp 
                165                 170                 175     


Val Leu Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu 
            180                 185                 190         


Ser Ala His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly 
        195                 200                 205             


Met Pro Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys 
    210                 215                 220                 


Gln Gly Lys Gly Thr Ala Asp Glu Thr Ser Lys Ser Gly Lys Gln Ser 
225                 230                 235                 240 


Ile Ala Ile Asp Asp Cys Thr Phe His Gln Cys Val Arg Leu Ser Lys 
                245                 250                 255     


Phe Asp Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe 
            260                 265                 270         


Glu Leu Met Arg Tyr Arg Thr Thr Lys Asp Ile Ile Leu Pro Phe Arg 
        275                 280                 285             


Val Ile Pro Leu Val Arg Glu Val Gly Arg Thr Lys Leu Glu Val Lys 
    290                 295                 300                 


Val Val Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile 
305                 310                 315                 320 


Glu Val Arg Ile Pro Thr Pro Leu Asn Thr Ser Gly Val Gln Val Ile 
                325                 330                 335     


Cys Met Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val 
            340                 345                 350         


Trp Lys Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala 
        355                 360                 365             


Glu Ile Glu Leu Leu Pro Thr Asn Asp Lys Lys Lys Trp Ala Arg Pro 
    370                 375                 380                 


Pro Ile Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys 
385                 390                 395                 400 


Val Arg Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His 
                405                 410                 415     


Asp Val Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu 
            420                 425                 430         


Thr Arg Cys 
        435 


<210> 40
<211> 920
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210> 41
<211> 742
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210> 42
<211> 339
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210> 43
<211> 412
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210> 44
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe 
    130                 135                 140                 


Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys 
            260                 265                 270         


His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210> 45
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                85                  90                  95      


Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
            100                 105                 110         


Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
        115                 120                 125             


Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
    130                 135                 140                 


Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
145                 150                 155                 160 


Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
                165                 170                 175     


Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
            180                 185                 190         


Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
        195                 200                 205             


Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
    210                 215                 220                 


Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
225                 230                 235                 240 


Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                245                 250                 255     


Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
            260                 265                 270         


Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
    290                 295                 300                 


Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
305                 310                 315                 320 


Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                325                 330     


<210> 46
<211> 334
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp 
            20                  25                  30          


Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly 
    50                  55                  60                  


Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg 
                85                  90                  95      


Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu 
            100                 105                 110         


Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln 
                165                 170                 175     


Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp 
        195                 200                 205             


Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val 
225                 230                 235                 240 


Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser 
                245                 250                 255     


Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser 
            260                 265                 270         


Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly 
        275                 280                 285             


Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn 
305                 310                 315                 320 


Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
                325                 330                 


<210> 47
<211> 433
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210> 48
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210> 49
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala 
1               5                   10                  15      


Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly 
            20                  25                  30          


Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser 
        35                  40                  45              


Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp 
    50                  55                  60                  


Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly 
                85                  90                  95      


Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr 
            100                 105                 110         


His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg 
        115                 120                 125             


Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe His Lys 
145                 150                 155                 160 


Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met 
                165                 170                 175     


Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu 
            180                 185                 190         


His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys 
        195                 200                 205             


Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys 
    210                 215                 220                 


Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val 
225                 230                 235                 240 


Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala 
                245                 250                 255     


Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile 
            260                 265                 270         


Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr 
        275                 280                 285             


Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp 
    290                 295                 300                 


Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met 
305                 310                 315                 320 


Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn 
                325                 330                 335     


Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys 
            340                 345                 350         


Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu 
        355                 360                 365             


Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys 
    370                 375                 380                 


Cys Gly Asp Arg Pro Gly Leu Leu Asn Val Gly His Ile Glu Lys Met 
385                 390                 395                 400 


Gln Glu Gly Ile Val His Val Leu Arg Leu His Leu Gln Ser Asn His 
                405                 410                 415     


Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp 
            420                 425                 430         


Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val Gln Ile Ile Lys 
        435                 440                 445             


Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu Gln Glu Ile Tyr 
    450                 455                 460                 


Arg Asp Met Tyr 
465             


<210> 50
<211> 273
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Gly Ser Gly Trp Val Pro Trp Val Val Ala Leu Leu Val Asn Leu 
1               5                   10                  15      


Thr Arg Leu Asp Ser Ser Met Thr Gln Gly Thr Asp Ser Pro Glu Asp 
            20                  25                  30          


Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr Phe Thr Asn Gly Thr Glu 
        35                  40                  45              


Lys Val Gln Phe Val Val Arg Phe Ile Phe Asn Leu Glu Glu Tyr Val 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Met Phe Val Ala Leu Thr Lys Leu Gly 
65                  70                  75                  80  


Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg Leu Asp Leu Leu Glu Arg 
                85                  90                  95      


Ser Arg Gln Ala Val Asp Gly Val Cys Arg His Asn Tyr Arg Leu Gly 
            100                 105                 110         


Ala Pro Phe Thr Val Gly Arg Lys Val Gln Pro Glu Val Thr Val Tyr 
        115                 120                 125             


Pro Glu Arg Thr Pro Leu Leu His Gln His Asn Leu Leu His Cys Ser 
    130                 135                 140                 


Val Thr Gly Phe Tyr Pro Gly Asp Ile Lys Ile Lys Trp Phe Leu Asn 
145                 150                 155                 160 


Gly Gln Glu Glu Arg Ala Gly Val Met Ser Thr Gly Pro Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Thr Val Val Met Leu Glu Met Thr Pro Glu 
            180                 185                 190         


Leu Gly His Val Tyr Thr Cys Leu Val Asp His Ser Ser Leu Leu Ser 
        195                 200                 205             


Pro Val Ser Val Glu Trp Arg Ala Gln Ser Glu Tyr Ser Trp Arg Lys 
    210                 215                 220                 


Met Leu Ser Gly Ile Ala Ala Phe Leu Leu Gly Leu Ile Phe Leu Leu 
225                 230                 235                 240 


Val Gly Ile Val Ile Gln Leu Arg Ala Gln Lys Gly Tyr Val Arg Thr 
                245                 250                 255     


Gln Met Ser Gly Asn Glu Val Ser Arg Ala Val Leu Leu Pro Gln Ser 
            260                 265                 270         


Cys 
    


<210> 51
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210> 52
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210> 53
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210> 54
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210> 55
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Ser Trp Lys Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala 
1               5                   10                  15      


Ala Val Thr Val Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala 
            20                  25                  30          


Arg Asp Phe Pro Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln 
65                  70                  75                  80  


Ala Val Thr Glu Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys 
                85                  90                  95      


Asp Phe Leu Glu Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His 
            100                 105                 110         


Asn Tyr Glu Ala Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro 
        115                 120                 125             


Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val 
145                 150                 155                 160 


Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr 
                165                 170                 175     


Ser Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu 
            180                 185                 190         


Glu Ile Thr Pro Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His 
        195                 200                 205             


Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu 
    210                 215                 220                 


Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly 
225                 230                 235                 240 


Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg His Arg Gly Gln Lys 
                245                 250                 255     


Gly Pro Arg Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265             


<210> 56
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210> 57
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210> 58
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210> 59
<211> 1181
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210> 60
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210> 61
<211> 317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210> 62
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210> 63
<211> 1051
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210> 64
<211> 798
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210> 65
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
            20                  25                  30          


Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
        35                  40                  45              


Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
    50                  55                  60                  


Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
65                  70                  75                  80  


Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                85                  90                  95      


Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
            100                 105                 110         


Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
        115                 120                 125             


Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
    130                 135                 140                 


Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
145                 150                 155                 160 


Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                165                 170                 175     


Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
            180                 185                 190         


Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
        195                 200                 205             


Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
    210                 215                 220                 


Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
225                 230                 235                 240 


Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                245                 250                 255     


Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
            260                 265                 270         


His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
        275                 280                 285             


Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
    290                 295                 300                 


Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
305                 310                 315                 320 


Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                325                 330                 335     


Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
            340                 345                 350         


Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
        355                 360                 365             


Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
    370                 375                 380                 


Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
385                 390                 395                 400 


Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                405                 410                 415     


Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
            420                 425                 430         


Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
        435                 440                 445             


Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
    450                 455                 460                 


Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
465                 470                 475 


<210> 66
<211> 357
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          


Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              


Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  


Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His 
65                  70                  75                  80  


Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu 
                85                  90                  95      


Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile 
            100                 105                 110         


Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys 
        115                 120                 125             


Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp 
    130                 135                 140                 


Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr 
145                 150                 155                 160 


Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe 
                165                 170                 175     


Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr 
            180                 185                 190         


Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp 
        195                 200                 205             


Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu 
    210                 215                 220                 


Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg 
225                 230                 235                 240 


Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg 
                245                 250                 255     


Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys 
            260                 265                 270         


Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile 
        275                 280                 285             


Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys 
    290                 295                 300                 


Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser 
305                 310                 315                 320 


Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr 
                325                 330                 335     


Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala 
            340                 345                 350         


Arg His Asn Glu Leu 
        355         


<210> 67
<211> 431
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210> 68
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys 
1               5                   10                  15      


Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly 
            20                  25                  30          


Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr 
        35                  40                  45              


Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu 
    50                  55                  60                  


Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg 
65                  70                  75                  80  


Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp 
                85                  90                  95      


Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser 
            100                 105                 110         


Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu 
        115                 120                 125             


Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys 
    130                 135                 140                 


Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro 
145                 150                 155                 160 


Lys Asp Asp Arg His Leu Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro 
                165                 170                 175     


Gly Ser Asn Gly Phe His Asn Asn Asp Thr Phe His Phe Leu Lys Cys 
            180                 185                 190         


Cys Asn Thr Thr Lys Cys Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn 
        195                 200                 205             


Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr 
    210                 215                 220                 


His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro 
225                 230                 235                 240 


Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro Lys Asn Gln 
                245                 250                 255     


Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys Gln His Ala 
            260                 265                 270         


His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val Ser Cys Cys 
        275                 280                 285             


Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln Tyr Arg Ser 
    290                 295                 300                 


Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu Thr Ile Thr 
305                 310                 315                 320 


Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu Trp Thr 
                325                 330                 335 


<210> 69
<211> 3460
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg 
            20                  25                  30          


Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly 
        35                  40                  45              


Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn 
    50                  55                  60                  


Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr 
65                  70                  75                  80  


Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr 
                85                  90                  95      


Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe 
            100                 105                 110         


Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val 
        115                 120                 125             


Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile 
    130                 135                 140                 


Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr 
145                 150                 155                 160 


Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln 
                165                 170                 175     


Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu 
            180                 185                 190         


Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser 
        195                 200                 205             


Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn 
    210                 215                 220                 


Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val 
225                 230                 235                 240 


Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu 
                245                 250                 255     


Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser 
            260                 265                 270         


Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys 
        275                 280                 285             


Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser 
    290                 295                 300                 


Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys 
305                 310                 315                 320 


Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly 
                325                 330                 335     


Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn 
            340                 345                 350         


Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp 
        355                 360                 365             


Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys 
    370                 375                 380                 


Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu 
385                 390                 395                 400 


Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile 
                405                 410                 415     


Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp 
            420                 425                 430         


Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly 
        435                 440                 445             


Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro 
    450                 455                 460                 


Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met 
465                 470                 475                 480 


Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu 
                485                 490                 495     


Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu 
            500                 505                 510         


Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn 
        515                 520                 525             


Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn 
    530                 535                 540                 


His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val 
545                 550                 555                 560 


Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile 
                565                 570                 575     


Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu 
            580                 585                 590         


Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys 
        595                 600                 605             


Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr 
    610                 615                 620                 


Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro 
625                 630                 635                 640 


Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly 
                645                 650                 655     


Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro 
            660                 665                 670         


Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly 
        675                 680                 685             


Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser 
    690                 695                 700                 


Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu 
705                 710                 715                 720 


Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe 
                725                 730                 735     


Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Asp 
            740                 745                 750         


Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg 
        755                 760                 765             


Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr 
    770                 775                 780                 


Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser 
785                 790                 795                 800 


Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu 
                805                 810                 815     


Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala 
            820                 825                 830         


Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser 
        835                 840                 845             


Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val 
    850                 855                 860                 


Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr 
865                 870                 875                 880 


Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His 
                885                 890                 895     


Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met 
            900                 905                 910         


Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile 
        915                 920                 925             


Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met 
    930                 935                 940                 


Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp 
945                 950                 955                 960 


His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu 
                965                 970                 975     


Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg 
            980                 985                 990         


Arg Val Ile Val Leu Leu Pro Gln  Lys Thr Trp Ser Ser  Ala Thr Arg 
        995                 1000                 1005             


Phe Arg  Trp Ser Gln Ser Tyr  Tyr Thr Ala Gln Asp  Glu Trp Ala 
    1010                 1015                 1020             


Leu Asp  Ser Ile Tyr Ile Gly  Gln Gln Cys Pro Asn  Met Cys Ser 
    1025                 1030                 1035             


Gly His  Gly Ser Cys Asp His  Gly Ile Cys Arg Cys  Asp Gln Gly 
    1040                 1045                 1050             


Tyr Gln  Gly Thr Glu Cys His  Pro Glu Ala Ala Leu  Pro Ser Thr 
    1055                 1060                 1065             


Ile Met  Ser Asp Phe Glu Asn  Gln Asn Gly Trp Glu  Ser Asp Trp 
    1070                 1075                 1080             


Gln Glu  Val Ile Gly Gly Glu  Ile Val Lys Pro Glu  Gln Gly Cys 
    1085                 1090                 1095             


Gly Val  Ile Ser Ser Gly Ser  Ser Leu Tyr Phe Ser  Lys Ala Gly 
    1100                 1105                 1110             


Lys Arg  Gln Leu Val Ser Trp  Asp Leu Asp Thr Ser  Trp Val Asp 
    1115                 1120                 1125             


Phe Val  Gln Phe Tyr Ile Gln  Ile Gly Gly Glu Ser  Ala Ser Cys 
    1130                 1135                 1140             


Asn Lys  Pro Asp Ser Arg Glu  Glu Gly Val Leu Leu  Gln Tyr Ser 
    1145                 1150                 1155             


Asn Asn  Gly Gly Ile Gln Trp  His Leu Leu Ala Glu  Met Tyr Phe 
    1160                 1165                 1170             


Ser Asp  Phe Ser Lys Pro Arg  Phe Val Tyr Leu Glu  Leu Pro Ala 
    1175                 1180                 1185             


Ala Ala  Lys Thr Pro Cys Thr  Arg Phe Arg Trp Trp  Gln Pro Val 
    1190                 1195                 1200             


Phe Ser  Gly Glu Asp Tyr Asp  Gln Trp Ala Val Asp  Asp Ile Ile 
    1205                 1210                 1215             


Ile Leu  Ser Glu Lys Gln Lys  Gln Ile Ile Pro Val  Ile Asn Pro 
    1220                 1225                 1230             


Thr Leu  Pro Gln Asn Phe Tyr  Glu Lys Pro Ala Phe  Asp Tyr Pro 
    1235                 1240                 1245             


Met Asn  Gln Met Ser Val Trp  Leu Met Leu Ala Asn  Glu Gly Met 
    1250                 1255                 1260             


Val Lys  Asn Glu Thr Phe Cys  Ala Ala Thr Pro Ser  Ala Met Ile 
    1265                 1270                 1275             


Phe Gly  Lys Ser Asp Gly Asp  Arg Phe Ala Val Thr  Arg Asp Leu 
    1280                 1285                 1290             


Thr Leu  Lys Pro Gly Tyr Val  Leu Gln Phe Lys Leu  Asn Ile Gly 
    1295                 1300                 1305             


Cys Ala  Asn Gln Phe Ser Ser  Thr Ala Pro Val Leu  Leu Gln Tyr 
    1310                 1315                 1320             


Ser His  Asp Ala Gly Met Ser  Trp Phe Leu Val Lys  Glu Gly Cys 
    1325                 1330                 1335             


Tyr Pro  Ala Ser Ala Gly Lys  Gly Cys Glu Gly Asn  Ser Arg Glu 
    1340                 1345                 1350             


Leu Ser  Glu Pro Thr Met Tyr  His Thr Gly Asp Phe  Glu Glu Trp 
    1355                 1360                 1365             


Thr Arg  Ile Thr Ile Val Ile  Pro Arg Ser Leu Ala  Ser Ser Lys 
    1370                 1375                 1380             


Thr Arg  Phe Arg Trp Ile Gln  Glu Ser Ser Ser Gln  Lys Asn Val 
    1385                 1390                 1395             


Pro Pro  Phe Gly Leu Asp Gly  Val Tyr Ile Ser Glu  Pro Cys Pro 
    1400                 1405                 1410             


Ser Tyr  Cys Ser Gly His Gly  Asp Cys Ile Ser Gly  Val Cys Phe 
    1415                 1420                 1425             


Cys Asp  Leu Gly Tyr Thr Ala  Ala Gln Gly Thr Cys  Val Ser Asn 
    1430                 1435                 1440             


Val Pro  Asn His Asn Glu Met  Phe Asp Arg Phe Glu  Gly Lys Leu 
    1445                 1450                 1455             


Ser Pro  Leu Trp Tyr Lys Ile  Thr Gly Ala Gln Val  Gly Thr Gly 
    1460                 1465                 1470             


Cys Gly  Thr Leu Asn Asp Gly  Lys Ser Leu Tyr Phe  Asn Gly Pro 
    1475                 1480                 1485             


Gly Lys  Arg Glu Ala Arg Thr  Val Pro Leu Asp Thr  Arg Asn Ile 
    1490                 1495                 1500             


Arg Leu  Val Gln Phe Tyr Ile  Gln Ile Gly Ser Lys  Thr Ser Gly 
    1505                 1510                 1515             


Ile Thr  Cys Ile Lys Pro Arg  Thr Arg Asn Glu Gly  Leu Ile Val 
    1520                 1525                 1530             


Gln Tyr  Ser Asn Asp Asn Gly  Ile Leu Trp His Leu  Leu Arg Glu 
    1535                 1540                 1545             


Leu Asp  Phe Met Ser Phe Leu  Glu Pro Gln Ile Ile  Ser Ile Asp 
    1550                 1555                 1560             


Leu Pro  Gln Asp Ala Lys Thr  Pro Ala Thr Ala Phe  Arg Trp Trp 
    1565                 1570                 1575             


Gln Pro  Gln His Gly Lys His  Ser Ala Gln Trp Ala  Leu Asp Asp 
    1580                 1585                 1590             


Val Leu  Ile Gly Met Asn Asp  Ser Ser Gln Thr Gly  Phe Gln Asp 
    1595                 1600                 1605             


Lys Phe  Asp Gly Ser Ile Asp  Leu Gln Ala Asn Trp  Tyr Arg Ile 
    1610                 1615                 1620             


Gln Gly  Gly Gln Val Asp Ile  Asp Cys Leu Ser Met  Asp Thr Ala 
    1625                 1630                 1635             


Leu Ile  Phe Thr Glu Asn Ile  Gly Lys Pro Arg Tyr  Ala Glu Thr 
    1640                 1645                 1650             


Trp Asp  Phe His Val Ser Ala  Ser Thr Phe Leu Gln  Phe Glu Met 
    1655                 1660                 1665             


Ser Met  Gly Cys Ser Lys Pro  Phe Ser Asn Ser His  Ser Val Gln 
    1670                 1675                 1680             


Leu Gln  Tyr Ser Leu Asn Asn  Gly Lys Asp Trp His  Leu Val Thr 
    1685                 1690                 1695             


Glu Glu  Cys Val Pro Pro Thr  Ile Gly Cys Leu His  Tyr Thr Glu 
    1700                 1705                 1710             


Ser Ser  Ile Tyr Thr Ser Glu  Arg Phe Gln Asn Trp  Lys Arg Ile 
    1715                 1720                 1725             


Thr Val  Tyr Leu Pro Leu Ser  Thr Ile Ser Pro Arg  Thr Arg Phe 
    1730                 1735                 1740             


Arg Trp  Ile Gln Ala Asn Tyr  Thr Val Gly Ala Asp  Ser Trp Ala 
    1745                 1750                 1755             


Ile Asp  Asn Val Val Leu Ala  Ser Gly Cys Pro Trp  Met Cys Ser 
    1760                 1765                 1770             


Gly Arg  Gly Ile Cys Asp Ala  Gly Arg Cys Val Cys  Asp Arg Gly 
    1775                 1780                 1785             


Phe Gly  Gly Pro Tyr Cys Val  Pro Val Val Pro Leu  Pro Ser Ile 
    1790                 1795                 1800             


Leu Lys  Asp Asp Phe Asn Gly  Asn Leu His Pro Asp  Leu Trp Pro 
    1805                 1810                 1815             


Glu Val  Tyr Gly Ala Glu Arg  Gly Asn Leu Asn Gly  Glu Thr Ile 
    1820                 1825                 1830             


Lys Ser  Gly Thr Ser Leu Ile  Phe Lys Gly Glu Gly  Leu Arg Met 
    1835                 1840                 1845             


Leu Ile  Ser Arg Asp Leu Asp  Cys Thr Asn Thr Met  Tyr Val Gln 
    1850                 1855                 1860             


Phe Ser  Leu Arg Phe Ile Ala  Lys Ser Thr Pro Glu  Arg Ser His 
    1865                 1870                 1875             


Ser Ile  Leu Leu Gln Phe Ser  Ile Ser Gly Gly Ile  Thr Trp His 
    1880                 1885                 1890             


Leu Met  Asp Glu Phe Tyr Phe  Pro Gln Thr Thr Asn  Ile Leu Phe 
    1895                 1900                 1905             


Ile Asn  Val Pro Leu Pro Tyr  Thr Ala Gln Thr Asn  Ala Thr Arg 
    1910                 1915                 1920             


Phe Arg  Leu Trp Gln Pro Tyr  Asn Asn Gly Lys Lys  Glu Glu Ile 
    1925                 1930                 1935             


Trp Ile  Val Asp Asp Phe Ile  Ile Asp Gly Asn Asn  Val Asn Asn 
    1940                 1945                 1950             


Pro Val  Met Leu Leu Asp Thr  Phe Asp Phe Gly Pro  Arg Glu Asp 
    1955                 1960                 1965             


Asn Trp  Phe Phe Tyr Pro Gly  Gly Asn Ile Gly Leu  Tyr Cys Pro 
    1970                 1975                 1980             


Tyr Ser  Ser Lys Gly Ala Pro  Glu Glu Asp Ser Ala  Met Val Phe 
    1985                 1990                 1995             


Val Ser  Asn Glu Val Gly Glu  His Ser Ile Thr Thr  Arg Asp Leu 
    2000                 2005                 2010             


Asn Val  Asn Glu Asn Thr Ile  Ile Gln Phe Glu Ile  Asn Val Gly 
    2015                 2020                 2025             


Cys Ser  Thr Asp Ser Ser Ser  Ala Asp Pro Val Arg  Leu Glu Phe 
    2030                 2035                 2040             


Ser Arg  Asp Phe Gly Ala Thr  Trp His Leu Leu Leu  Pro Leu Cys 
    2045                 2050                 2055             


Tyr His  Ser Ser Ser His Val  Ser Ser Leu Cys Ser  Thr Glu His 
    2060                 2065                 2070             


His Pro  Ser Ser Thr Tyr Tyr  Ala Gly Thr Met Gln  Gly Trp Arg 
    2075                 2080                 2085             


Arg Glu  Val Val His Phe Gly  Lys Leu His Leu Cys  Gly Ser Val 
    2090                 2095                 2100             


Arg Phe  Arg Trp Tyr Gln Gly  Phe Tyr Pro Ala Gly  Ser Gln Pro 
    2105                 2110                 2115             


Val Thr  Trp Ala Ile Asp Asn  Val Tyr Ile Gly Pro  Gln Cys Glu 
    2120                 2125                 2130             


Glu Met  Cys Asn Gly Gln Gly  Ser Cys Ile Asn Gly  Thr Lys Cys 
    2135                 2140                 2145             


Ile Cys  Asp Pro Gly Tyr Ser  Gly Pro Thr Cys Lys  Ile Ser Thr 
    2150                 2155                 2160             


Lys Asn  Pro Asp Phe Leu Lys  Asp Asp Phe Glu Gly  Gln Leu Glu 
    2165                 2170                 2175             


Ser Asp  Arg Phe Leu Leu Met  Ser Gly Gly Lys Pro  Ser Arg Lys 
    2180                 2185                 2190             


Cys Gly  Ile Leu Ser Ser Gly  Asn Asn Leu Phe Phe  Asn Glu Asp 
    2195                 2200                 2205             


Gly Leu  Arg Met Leu Met Thr  Arg Asp Leu Asp Leu  Ser His Ala 
    2210                 2215                 2220             


Arg Phe  Val Gln Phe Phe Met  Arg Leu Gly Cys Gly  Lys Gly Val 
    2225                 2230                 2235             


Pro Asp  Pro Arg Ser Gln Pro  Val Leu Leu Gln Tyr  Ser Leu Asn 
    2240                 2245                 2250             


Gly Gly  Leu Ser Trp Ser Leu  Leu Gln Glu Phe Leu  Phe Ser Asn 
    2255                 2260                 2265             


Ser Ser  Asn Val Gly Arg Tyr  Ile Ala Leu Glu Ile  Pro Leu Lys 
    2270                 2275                 2280             


Ala Arg  Ser Gly Ser Thr Arg  Leu Arg Trp Trp Gln  Pro Ser Glu 
    2285                 2290                 2295             


Asn Gly  His Phe Tyr Ser Pro  Trp Val Ile Asp Gln  Ile Leu Ile 
    2300                 2305                 2310             


Gly Gly  Asn Ile Ser Gly Asn  Thr Val Leu Glu Asp  Asp Phe Thr 
    2315                 2320                 2325             


Thr Leu  Asp Ser Arg Lys Trp  Leu Leu His Pro Gly  Gly Thr Lys 
    2330                 2335                 2340             


Met Pro  Val Cys Gly Ser Thr  Gly Asp Ala Leu Val  Phe Ile Glu 
    2345                 2350                 2355             


Lys Ala  Ser Thr Arg Tyr Val  Val Ser Thr Asp Val  Ala Val Asn 
    2360                 2365                 2370             


Glu Asp  Ser Phe Leu Gln Ile  Asp Phe Ala Ala Ser  Cys Ser Val 
    2375                 2380                 2385             


Thr Asp  Ser Cys Tyr Ala Ile  Glu Leu Glu Tyr Ser  Val Asp Leu 
    2390                 2395                 2400             


Gly Leu  Ser Trp His Pro Leu  Val Arg Asp Cys Leu  Pro Thr Asn 
    2405                 2410                 2415             


Val Glu  Cys Ser Arg Tyr His  Leu Gln Arg Ile Leu  Val Ser Asp 
    2420                 2425                 2430             


Thr Phe  Asn Lys Trp Thr Arg  Ile Thr Leu Pro Leu  Pro Pro Tyr 
    2435                 2440                 2445             


Thr Arg  Ser Gln Ala Thr Arg  Phe Arg Trp His Gln  Pro Ala Pro 
    2450                 2455                 2460             


Phe Asp  Lys Gln Gln Thr Trp  Ala Ile Asp Asn Val  Tyr Ile Gly 
    2465                 2470                 2475             


Asp Gly  Cys Ile Asp Met Cys  Ser Gly His Gly Arg  Cys Ile Gln 
    2480                 2485                 2490             


Gly Asn  Cys Val Cys Asp Glu  Gln Trp Gly Gly Leu  Tyr Cys Asp 
    2495                 2500                 2505             


Asp Pro  Glu Thr Ser Leu Pro  Thr Gln Leu Lys Asp  Asn Phe Asn 
    2510                 2515                 2520             


Arg Ala  Pro Ser Ser Gln Asn  Trp Leu Thr Val Asn  Gly Gly Lys 
    2525                 2530                 2535             


Leu Ser  Thr Val Cys Gly Ala  Val Ala Ser Gly Met  Ala Leu His 
    2540                 2545                 2550             


Phe Ser  Gly Gly Cys Ser Arg  Leu Leu Val Thr Val  Asp Leu Asn 
    2555                 2560                 2565             


Leu Thr  Asn Ala Glu Phe Ile  Gln Phe Tyr Phe Met  Tyr Gly Cys 
    2570                 2575                 2580             


Leu Ile  Thr Pro Asn Asn Arg  Asn Gln Gly Val Leu  Leu Glu Tyr 
    2585                 2590                 2595             


Ser Val  Asn Gly Gly Ile Thr  Trp Asn Leu Leu Met  Glu Ile Phe 
    2600                 2605                 2610             


Tyr Asp  Gln Tyr Ser Lys Pro  Gly Phe Val Asn Ile  Leu Leu Pro 
    2615                 2620                 2625             


Pro Asp  Ala Lys Glu Ile Ala  Thr Arg Phe Arg Trp  Trp Gln Pro 
    2630                 2635                 2640             


Arg His  Asp Gly Leu Asp Gln  Asn Asp Trp Ala Ile  Asp Asn Val 
    2645                 2650                 2655             


Leu Ile  Ser Gly Ser Ala Asp  Gln Arg Thr Val Met  Leu Asp Thr 
    2660                 2665                 2670             


Phe Ser  Ser Ala Pro Val Pro  Gln His Glu Arg Ser  Pro Ala Asp 
    2675                 2680                 2685             


Ala Gly  Pro Val Gly Arg Ile  Ala Phe Asp Met Phe  Met Glu Asp 
    2690                 2695                 2700             


Lys Thr  Ser Val Asn Glu His  Trp Leu Phe His Asp  Asp Cys Thr 
    2705                 2710                 2715             


Val Glu  Arg Phe Cys Asp Ser  Pro Asp Gly Val Met  Leu Cys Gly 
    2720                 2725                 2730             


Ser His  Asp Gly Arg Glu Val  Tyr Ala Val Thr His  Asp Leu Thr 
    2735                 2740                 2745             


Pro Thr  Glu Gly Trp Ile Met  Gln Phe Lys Ile Ser  Val Gly Cys 
    2750                 2755                 2760             


Lys Val  Ser Glu Lys Ile Ala  Gln Asn Gln Ile His  Val Gln Tyr 
    2765                 2770                 2775             


Ser Thr  Asp Phe Gly Val Ser  Trp Asn Tyr Leu Val  Pro Gln Cys 
    2780                 2785                 2790             


Leu Pro  Ala Asp Pro Lys Cys  Ser Gly Ser Val Ser  Gln Pro Ser 
    2795                 2800                 2805             


Val Phe  Phe Pro Thr Lys Gly  Trp Lys Arg Ile Thr  Tyr Pro Leu 
    2810                 2815                 2820             


Pro Glu  Ser Leu Val Gly Asn  Pro Val Arg Phe Arg  Phe Tyr Gln 
    2825                 2830                 2835             


Lys Tyr  Ser Asp Met Gln Trp  Ala Ile Asp Asn Phe  Tyr Leu Gly 
    2840                 2845                 2850             


Pro Gly  Cys Leu Asp Asn Cys  Arg Gly His Gly Asp  Cys Leu Arg 
    2855                 2860                 2865             


Glu Gln  Cys Ile Cys Asp Pro  Gly Tyr Ser Gly Pro  Asn Cys Tyr 
    2870                 2875                 2880             


Leu Thr  His Thr Leu Lys Thr  Phe Leu Lys Glu Arg  Phe Asp Ser 
    2885                 2890                 2895             


Glu Glu  Ile Lys Pro Asp Leu  Trp Met Ser Leu Glu  Gly Gly Ser 
    2900                 2905                 2910             


Thr Cys  Thr Glu Cys Gly Ile  Leu Ala Glu Asp Thr  Ala Leu Tyr 
    2915                 2920                 2925             


Phe Gly  Gly Ser Thr Val Arg  Gln Ala Val Thr Gln  Asp Leu Asp 
    2930                 2935                 2940             


Leu Arg  Gly Ala Lys Phe Leu  Gln Tyr Trp Gly Arg  Ile Gly Ser 
    2945                 2950                 2955             


Glu Asn  Asn Met Thr Ser Cys  His Arg Pro Ile Cys  Arg Lys Glu 
    2960                 2965                 2970             


Gly Val  Leu Leu Asp Tyr Ser  Thr Asp Gly Gly Ile  Thr Trp Thr 
    2975                 2980                 2985             


Leu Leu  His Glu Met Asp Tyr  Gln Lys Tyr Ile Ser  Val Arg His 
    2990                 2995                 3000             


Asp Tyr  Ile Leu Leu Pro Glu  Asp Ala Leu Thr Asn  Thr Thr Arg 
    3005                 3010                 3015             


Leu Arg  Trp Trp Gln Pro Phe  Val Ile Ser Asn Gly  Ile Val Val 
    3020                 3025                 3030             


Ser Gly  Val Glu Arg Ala Gln  Trp Ala Leu Asp Asn  Ile Leu Ile 
    3035                 3040                 3045             


Gly Gly  Ala Glu Ile Asn Pro  Ser Gln Leu Val Asp  Thr Phe Asp 
    3050                 3055                 3060             


Asp Glu  Gly Thr Ser His Glu  Glu Asn Trp Ser Phe  Tyr Pro Asn 
    3065                 3070                 3075             


Ala Val  Arg Thr Ala Gly Phe  Cys Gly Asn Pro Ser  Phe His Leu 
    3080                 3085                 3090             


Tyr Trp  Pro Asn Lys Lys Lys  Asp Lys Thr His Asn  Ala Leu Ser 
    3095                 3100                 3105             


Ser Arg  Glu Leu Ile Ile Gln  Pro Gly Tyr Met Met  Gln Phe Lys 
    3110                 3115                 3120             


Ile Val  Val Gly Cys Glu Ala  Thr Ser Cys Gly Asp  Leu His Ser 
    3125                 3130                 3135             


Val Met  Leu Glu Tyr Thr Lys  Asp Ala Arg Ser Asp  Ser Trp Gln 
    3140                 3145                 3150             


Leu Val  Gln Thr Gln Cys Leu  Pro Ser Ser Ser Asn  Ser Ile Gly 
    3155                 3160                 3165             


Cys Ser  Pro Phe Gln Phe His  Glu Ala Thr Ile Tyr  Asn Ser Val 
    3170                 3175                 3180             


Asn Ser  Ser Ser Trp Lys Arg  Ile Thr Ile Gln Leu  Pro Asp His 
    3185                 3190                 3195             


Val Ser  Ser Ser Ala Thr Gln  Phe Arg Trp Ile Gln  Lys Gly Glu 
    3200                 3205                 3210             


Glu Thr  Glu Lys Gln Ser Trp  Ala Ile Asp His Val  Tyr Ile Gly 
    3215                 3220                 3225             


Glu Ala  Cys Pro Lys Leu Cys  Ser Gly His Gly Tyr  Cys Thr Thr 
    3230                 3235                 3240             


Gly Ala  Ile Cys Ile Cys Asp  Glu Ser Phe Gln Gly  Asp Asp Cys 
    3245                 3250                 3255             


Ser Val  Phe Ser His Asp Leu  Pro Ser Tyr Ile Lys  Asp Asn Phe 
    3260                 3265                 3270             


Glu Ser  Ala Arg Val Thr Glu  Ala Asn Trp Glu Thr  Ile Gln Gly 
    3275                 3280                 3285             


Gly Val  Ile Gly Ser Gly Cys  Gly Gln Leu Ala Pro  Tyr Ala His 
    3290                 3295                 3300             


Gly Asp  Ser Leu Tyr Phe Asn  Gly Cys Gln Ile Arg  Gln Ala Ala 
    3305                 3310                 3315             


Thr Lys  Pro Leu Asp Leu Thr  Arg Ala Ser Lys Ile  Met Phe Val 
    3320                 3325                 3330             


Leu Gln  Ile Gly Ser Met Ser  Gln Thr Asp Ser Cys  Asn Ser Asp 
    3335                 3340                 3345             


Leu Ser  Gly Pro His Ala Val  Asp Lys Ala Val Leu  Leu Gln Tyr 
    3350                 3355                 3360             


Ser Val  Asn Asn Gly Ile Thr  Trp His Val Ile Ala  Gln His Gln 
    3365                 3370                 3375             


Pro Lys  Asp Phe Thr Gln Ala  Gln Arg Val Ser Tyr  Asn Val Pro 
    3380                 3385                 3390             


Leu Glu  Ala Arg Met Lys Gly  Val Leu Leu Arg Trp  Trp Gln Pro 
    3395                 3400                 3405             


Arg His  Asn Gly Thr Gly His  Asp Gln Trp Ala Leu  Asp His Val 
    3410                 3415                 3420             


Glu Val  Val Leu Val Ser Thr  Arg Lys Gln Asn Tyr  Met Met Asn 
    3425                 3430                 3435             


Phe Ser  Arg Gln His Gly Leu  Arg His Phe Tyr Asn  Arg Arg Arg 
    3440                 3445                 3450             


Arg Ser  Leu Arg Arg Tyr Pro  
    3455                 3460 


<210> 70
<211> 402
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210> 71
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Met Ala Gly Gly Ser Ala Thr Thr Trp Gly Tyr Pro Val Ala Leu Leu 
1               5                   10                  15      


Leu Leu Val Ala Thr Leu Gly Leu Gly Arg Trp Leu Gln Pro Asp Pro 
            20                  25                  30          


Gly Leu Pro Gly Leu Arg His Ser Tyr Asp Cys Gly Ile Lys Gly Met 
        35                  40                  45              


Gln Leu Leu Val Phe Pro Arg Pro Gly Gln Thr Leu Arg Phe Lys Val 
    50                  55                  60                  


Val Asp Glu Phe Gly Asn Arg Phe Asp Val Asn Asn Cys Ser Ile Cys 
65                  70                  75                  80  


Tyr His Trp Val Thr Ser Arg Pro Gln Glu Pro Ala Val Phe Ser Ala 
                85                  90                  95      


Asp Tyr Arg Gly Cys His Val Leu Glu Lys Asp Gly Arg Phe His Leu 
            100                 105                 110         


Arg Val Phe Met Glu Ala Val Leu Pro Asn Gly Arg Val Asp Val Ala 
        115                 120                 125             


Gln Asp Ala Thr Leu Ile Cys Pro Lys Pro Asp Pro Ser Arg Thr Leu 
    130                 135                 140                 


Asp Ser Gln Leu Ala Pro Pro Ala Met Phe Ser Val Ser Thr Pro Gln 
145                 150                 155                 160 


Thr Leu Ser Phe Leu Pro Thr Ser Gly His Thr Ser Gln Gly Ser Gly 
                165                 170                 175     


His Ala Phe Pro Ser Pro Leu Asp Pro Gly His Ser Ser Val His Pro 
            180                 185                 190         


Thr Pro Ala Leu Pro Ser Pro Gly Pro Gly Pro Thr Leu Ala Thr Leu 
        195                 200                 205             


Ala Gln Pro His Trp Gly Thr Leu Glu His Trp Asp Val Asn Lys Arg 
    210                 215                 220                 


Asp Tyr Ile Gly Thr His Leu Ser Gln Glu Gln Cys Gln Val Ala Ser 
225                 230                 235                 240 


Gly His Leu Pro Cys Ile Val Arg Arg Thr Ser Lys Glu Ala Cys Gln 
                245                 250                 255     


Gln Ala Gly Cys Cys Tyr Asp Asn Thr Arg Glu Val Pro Cys Tyr Tyr 
            260                 265                 270         


Gly Asn Thr Ala Thr Val Gln Cys Phe Arg Asp Gly Tyr Phe Val Leu 
        275                 280                 285             


Val Val Ser Gln Glu Met Ala Leu Thr His Arg Ile Thr Leu Ala Asn 
    290                 295                 300                 


Ile His Leu Ala Tyr Ala Pro Thr Ser Cys Ser Pro Thr Gln His Thr 
305                 310                 315                 320 


Glu Ala Phe Val Val Phe Tyr Phe Pro Leu Thr His Cys Gly Thr Thr 
                325                 330                 335     


Met Gln Val Ala Gly Asp Gln Leu Ile Tyr Glu Asn Trp Leu Val Ser 
            340                 345                 350         


Gly Ile His Ile Gln Lys Gly Pro Gln Gly Ser Ile Thr Arg Asp Ser 
        355                 360                 365             


Thr Phe Gln Leu His Val Arg Cys Val Phe Asn Ala Ser Asp Phe Leu 
    370                 375                 380                 


Pro Ile Gln Ala Ser Ile Phe Pro Pro Pro Ser Pro Ala Pro Met Thr 
385                 390                 395                 400 


Gln Pro Gly Pro Leu Arg Leu Glu Leu Arg Ile Ala Lys Asp Glu Thr 
                405                 410                 415     


Phe Ser Ser Tyr Tyr Gly Glu Asp Asp Tyr Pro Ile Val Arg Leu Leu 
            420                 425                 430         


Arg Glu Pro Val His Val Glu Val Arg Leu Leu Gln Arg Thr Asp Pro 
        435                 440                 445             


Asn Leu Val Leu Leu Leu His Gln Cys Trp Gly Ala Pro Ser Ala Asn 
    450                 455                 460                 


Pro Phe Gln Gln Pro Gln Trp Pro Ile Leu Ser Asp Gly Cys Pro Phe 
465                 470                 475                 480 


Lys Gly Asp Ser Tyr Arg Thr Gln Met Val Ala Leu Asp Gly Ala Thr 
                485                 490                 495     


Pro Phe Gln Ser His Tyr Gln Arg Phe Thr Val Ala Thr Phe Ala Leu 
            500                 505                 510         


Leu Asp Ser Gly Ser Gln Arg Ala Leu Arg Gly Leu Val Tyr Leu Phe 
        515                 520                 525             


Cys Ser Thr Ser Ala Cys His Thr Ser Gly Leu Glu Thr Cys Ser Thr 
    530                 535                 540                 


Ala Cys Ser Thr Gly Thr Thr Arg Gln Arg Arg Ser Ser Gly His Arg 
545                 550                 555                 560 


Asn Asp Thr Ala Arg Pro Gln Asp Ile Val Ser Ser Pro Gly Pro Val 
                565                 570                 575     


Gly Phe Glu Asp Ser Tyr Gly Gln Glu Pro Thr Leu Gly Pro Thr Asp 
            580                 585                 590         


Ser Asn Gly Asn Ser Ser Leu Arg Pro Leu Leu Trp Ala Val Leu Leu 
        595                 600                 605             


Leu Pro Ala Val Ala Leu Val Leu Gly Phe Gly Val Phe Val Gly Leu 
    610                 615                 620                 


Ser Gln Thr Trp Ala Gln Lys Leu Trp Glu Ser Asn Arg Gln 
625                 630                 635             


<210> 72
<211> 424
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Met Glu Leu Ser Tyr Arg Leu Phe Ile Cys Leu Leu Leu Trp Gly Ser 
1               5                   10                  15      


Thr Glu Leu Cys Tyr Pro Gln Pro Leu Trp Leu Leu Gln Gly Gly Ala 
            20                  25                  30          


Ser His Pro Glu Thr Ser Val Gln Pro Val Leu Val Glu Cys Gln Glu 
        35                  40                  45              


Ala Thr Leu Met Val Met Val Ser Lys Asp Leu Phe Gly Thr Gly Lys 
    50                  55                  60                  


Leu Ile Arg Ala Ala Asp Leu Thr Leu Gly Pro Glu Ala Cys Glu Pro 
65                  70                  75                  80  


Leu Val Ser Met Asp Thr Glu Asp Val Val Arg Phe Glu Val Gly Leu 
                85                  90                  95      


His Glu Cys Gly Asn Ser Met Gln Val Thr Asp Asp Ala Leu Val Tyr 
            100                 105                 110         


Ser Thr Phe Leu Leu His Asp Pro Arg Pro Val Gly Asn Leu Ser Ile 
        115                 120                 125             


Val Arg Thr Asn Arg Ala Glu Ile Pro Ile Glu Cys Arg Tyr Pro Arg 
    130                 135                 140                 


Gln Gly Asn Val Ser Ser Gln Ala Ile Leu Pro Thr Trp Leu Pro Phe 
145                 150                 155                 160 


Arg Thr Thr Val Phe Ser Glu Glu Lys Leu Thr Phe Ser Leu Arg Leu 
                165                 170                 175     


Met Glu Glu Asn Trp Asn Ala Glu Lys Arg Ser Pro Thr Phe His Leu 
            180                 185                 190         


Gly Asp Ala Ala His Leu Gln Ala Glu Ile His Thr Gly Ser His Val 
        195                 200                 205             


Pro Leu Arg Leu Phe Val Asp His Cys Val Ala Thr Pro Thr Pro Asp 
    210                 215                 220                 


Gln Asn Ala Ser Pro Tyr His Thr Ile Val Asp Phe His Gly Cys Leu 
225                 230                 235                 240 


Val Asp Gly Leu Thr Asp Ala Ser Ser Ala Phe Lys Val Pro Arg Pro 
                245                 250                 255     


Gly Pro Asp Thr Leu Gln Phe Thr Val Asp Val Phe His Phe Ala Asn 
            260                 265                 270         


Asp Ser Arg Asn Met Ile Tyr Ile Thr Cys His Leu Lys Val Thr Leu 
        275                 280                 285             


Ala Glu Gln Asp Pro Asp Glu Leu Asn Lys Ala Cys Ser Phe Ser Lys 
    290                 295                 300                 


Pro Ser Asn Ser Trp Phe Pro Val Glu Gly Ser Ala Asp Ile Cys Gln 
305                 310                 315                 320 


Cys Cys Asn Lys Gly Asp Cys Gly Thr Pro Ser His Ser Arg Arg Gln 
                325                 330                 335     


Pro His Val Met Ser Gln Trp Ser Arg Ser Ala Ser Arg Asn Arg Arg 
            340                 345                 350         


His Val Thr Glu Glu Ala Asp Val Thr Val Gly Pro Leu Ile Phe Leu 
        355                 360                 365             


Asp Arg Arg Gly Asp His Glu Val Glu Gln Trp Ala Leu Pro Ser Asp 
    370                 375                 380                 


Thr Ser Val Val Leu Leu Gly Val Gly Leu Ala Val Val Val Ser Leu 
385                 390                 395                 400 


Thr Leu Thr Ala Val Ile Leu Val Leu Thr Arg Arg Cys Arg Thr Ala 
                405                 410                 415     


Ser His Pro Val Ser Ala Ser Glu 
            420                 


<210> 73
<211> 540
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Met Trp Leu Leu Arg Cys Val Leu Leu Cys Val Ser Leu Ser Leu Ala 
1               5                   10                  15      


Val Ser Gly Gln His Lys Pro Glu Ala Pro Asp Tyr Ser Ser Val Leu 
            20                  25                  30          


His Cys Gly Pro Trp Ser Phe Gln Phe Ala Val Asn Leu Asn Gln Glu 
        35                  40                  45              


Ala Thr Ser Pro Pro Val Leu Ile Ala Trp Asp Asn Gln Gly Leu Leu 
    50                  55                  60                  


His Glu Leu Gln Asn Asp Ser Asp Cys Gly Thr Trp Ile Arg Lys Gly 
65                  70                  75                  80  


Pro Gly Ser Ser Val Val Leu Glu Ala Thr Tyr Ser Ser Cys Tyr Val 
                85                  90                  95      


Thr Glu Trp Asp Ser His Tyr Ile Met Pro Val Gly Val Glu Gly Ala 
            100                 105                 110         


Gly Ala Ala Glu His Lys Val Val Thr Glu Arg Lys Leu Leu Lys Cys 
        115                 120                 125             


Pro Met Asp Leu Leu Ala Arg Asp Ala Pro Asp Thr Asp Trp Cys Asp 
    130                 135                 140                 


Ser Ile Pro Ala Arg Asp Arg Leu Pro Cys Ala Pro Ser Pro Ile Ser 
145                 150                 155                 160 


Arg Gly Asp Cys Glu Gly Leu Gly Cys Cys Tyr Ser Ser Glu Glu Val 
                165                 170                 175     


Asn Ser Cys Tyr Tyr Gly Asn Thr Val Thr Leu His Cys Thr Arg Glu 
            180                 185                 190         


Gly His Phe Ser Ile Ala Val Ser Arg Asn Val Thr Ser Pro Pro Leu 
        195                 200                 205             


Leu Leu Asp Ser Val Arg Leu Ala Leu Arg Asn Asp Ser Ala Cys Asn 
    210                 215                 220                 


Pro Val Met Ala Thr Gln Ala Phe Val Leu Phe Gln Phe Pro Phe Thr 
225                 230                 235                 240 


Ser Cys Gly Thr Thr Arg Gln Ile Thr Gly Asp Arg Ala Val Tyr Glu 
                245                 250                 255     


Asn Glu Leu Val Ala Thr Arg Asp Val Lys Asn Gly Ser Arg Gly Ser 
            260                 265                 270         


Val Thr Arg Asp Ser Ile Phe Arg Leu His Val Ser Cys Ser Tyr Ser 
        275                 280                 285             


Val Ser Ser Asn Ser Leu Pro Ile Asn Val Gln Val Phe Thr Leu Pro 
    290                 295                 300                 


Pro Pro Phe Pro Glu Thr Gln Pro Gly Pro Leu Thr Leu Glu Leu Gln 
305                 310                 315                 320 


Ile Ala Lys Asp Lys Asn Tyr Gly Ser Tyr Tyr Gly Val Gly Asp Tyr 
                325                 330                 335     


Pro Val Val Lys Leu Leu Arg Asp Pro Ile Tyr Val Glu Val Ser Ile 
            340                 345                 350         


Leu His Arg Thr Asp Pro Tyr Leu Gly Leu Leu Leu Gln Gln Cys Trp 
        355                 360                 365             


Ala Thr Pro Ser Thr Asp Pro Leu Ser Gln Pro Gln Trp Pro Ile Leu 
    370                 375                 380                 


Val Lys Gly Cys Pro Tyr Ile Gly Asp Asn Tyr Gln Thr Gln Leu Ile 
385                 390                 395                 400 


Pro Val Gln Lys Ala Leu Asp Leu Pro Phe Pro Ser His His Gln Arg 
                405                 410                 415     


Phe Ser Ile Phe Thr Phe Ser Phe Val Asn Pro Thr Val Glu Lys Gln 
            420                 425                 430         


Ala Leu Arg Gly Pro Val His Leu His Cys Ser Val Ser Val Cys Gln 
        435                 440                 445             


Pro Ala Glu Thr Pro Ser Cys Val Val Thr Cys Pro Asp Leu Ser Arg 
    450                 455                 460                 


Arg Arg Asn Phe Asp Asn Ser Ser Gln Asn Thr Thr Ala Ser Val Ser 
465                 470                 475                 480 


Ser Lys Gly Pro Met Ile Leu Leu Gln Ala Thr Lys Asp Pro Pro Glu 
                485                 490                 495     


Lys Leu Arg Val Pro Val Asp Ser Lys Val Leu Trp Val Ala Gly Leu 
            500                 505                 510         


Ser Gly Thr Leu Ile Leu Gly Ala Leu Leu Val Ser Tyr Leu Ala Val 
        515                 520                 525             


Lys Lys Gln Lys Ser Cys Pro Asp Gln Met Cys Gln 
    530                 535                 540 


<210> 74
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Met Glu Ala Phe Ala Leu Gly Pro Ala Arg Arg Gly Arg Arg Arg Thr 
1               5                   10                  15      


Arg Ala Ala Gly Ser Leu Leu Ser Arg Ala Ala Ile Leu Leu Phe Ile 
            20                  25                  30          


Ser Ala Phe Leu Val Arg Val Pro Ser Ser Val Gly His Leu Val Arg 
        35                  40                  45              


Leu Pro Arg Ala Phe Arg Leu Thr Lys Asp Ser Val Lys Ile Val Gly 
    50                  55                  60                  


Ser Thr Ser Phe Pro Val Lys Ala Tyr Val Met Leu His Gln Lys Ser 
65                  70                  75                  80  


Pro His Val Leu Cys Val Thr Gln Gln Leu Arg Asn Ala Glu Leu Ile 
                85                  90                  95      


Asp Pro Ser Phe Gln Trp Tyr Gly Pro Lys Gly Lys Val Val Ser Val 
            100                 105                 110         


Glu Asn Arg Thr Ala Gln Ile Thr Ser Thr Gly Ser Leu Val Phe Gln 
        115                 120                 125             


Asn Phe Glu Glu Ser Met Ser Gly Ile Tyr Thr Cys Phe Leu Glu Tyr 
    130                 135                 140                 


Lys Pro Thr Val Glu Glu Ile Val Lys Arg Leu Gln Leu Lys Tyr Ala 
145                 150                 155                 160 


Ile Tyr Ala Tyr Arg Glu Pro His Tyr Tyr Tyr Gln Phe Thr Ala Arg 
                165                 170                 175     


Tyr His Ala Ala Pro Cys Asn Ser Ile Tyr Asn Ile Ser Phe Glu Lys 
            180                 185                 190         


Lys Leu Leu Gln Ile Leu Ser Lys Leu Leu Leu Asp Leu Ser Cys Glu 
        195                 200                 205             


Ile Ser Leu Leu Lys Ser Glu Cys His Arg Val Lys Met Gln Arg Ala 
    210                 215                 220                 


Gly Leu Gln Asn Glu Leu Phe Phe Ala Phe Ser Val Ser Ser Leu Asp 
225                 230                 235                 240 


Thr Glu Lys Gly Pro Lys Arg Cys Thr Asp His Asn Cys Glu Pro Tyr 
                245                 250                 255     


Lys Arg Leu Phe Lys Ala Lys Asn Leu Ile Glu Arg Phe Phe Asn Gln 
            260                 265                 270         


Gln Val Glu Ile Leu Gly Arg Arg Ala Glu Gln Leu Pro Gln Ile Tyr 
        275                 280                 285             


Tyr Ile Glu Gly Thr Leu Gln Met Val Trp Ile Asn Arg Cys Phe Pro 
    290                 295                 300                 


Gly Tyr Gly Met Asn Val Gln Gln His Pro Lys Cys Pro Glu Cys Cys 
305                 310                 315                 320 


Val Ile Cys Ser Pro Gly Ser Tyr Asn Pro Arg Asp Gly Ile His Cys 
                325                 330                 335     


Leu Gln Cys Asn Ser Ser Leu Val Tyr Gly Ala Lys Thr Cys Leu 
            340                 345                 350     


<210> 75
<211> 421
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Met Val Glu Met Leu Pro Thr Ala Ile Leu Leu Val Leu Ala Val Ser 
1               5                   10                  15      


Val Val Ala Lys Asp Asn Ala Thr Cys Asp Gly Pro Cys Gly Leu Arg 
            20                  25                  30          


Phe Arg Gln Asn Pro Gln Gly Gly Val Arg Ile Val Gly Gly Lys Ala 
        35                  40                  45              


Ala Gln His Gly Ala Trp Pro Trp Met Val Ser Leu Gln Ile Phe Thr 
    50                  55                  60                  


Tyr Asn Ser His Arg Tyr His Thr Cys Gly Gly Ser Leu Leu Asn Ser 
65                  70                  75                  80  


Arg Trp Val Leu Thr Ala Ala His Cys Phe Val Gly Lys Asn Asn Val 
                85                  90                  95      


His Asp Trp Arg Leu Val Phe Gly Ala Lys Glu Ile Thr Tyr Gly Asn 
            100                 105                 110         


Asn Lys Pro Val Lys Ala Pro Leu Gln Glu Arg Tyr Val Glu Lys Ile 
        115                 120                 125             


Ile Ile His Glu Lys Tyr Asn Ser Ala Thr Glu Gly Asn Asp Ile Ala 
    130                 135                 140                 


Leu Val Glu Ile Thr Pro Pro Ile Ser Cys Gly Arg Phe Ile Gly Pro 
145                 150                 155                 160 


Gly Cys Leu Pro His Phe Lys Ala Gly Leu Pro Arg Gly Ser Gln Ser 
                165                 170                 175     


Cys Trp Val Ala Gly Trp Gly Tyr Ile Glu Glu Lys Ala Pro Arg Pro 
            180                 185                 190         


Ser Ser Ile Leu Met Glu Ala Arg Val Asp Leu Ile Asp Leu Asp Leu 
        195                 200                 205             


Cys Asn Ser Thr Gln Trp Tyr Asn Gly Arg Val Gln Pro Thr Asn Val 
    210                 215                 220                 


Cys Ala Gly Tyr Pro Val Gly Lys Ile Asp Thr Cys Gln Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Pro Leu Met Cys Lys Asp Ser Lys Glu Ser Ala Tyr Val Val 
                245                 250                 255     


Val Gly Ile Thr Ser Trp Gly Val Gly Cys Ala Arg Ala Lys Arg Pro 
            260                 265                 270         


Gly Ile Tyr Thr Ala Thr Trp Pro Tyr Leu Asn Trp Ile Ala Ser Lys 
        275                 280                 285             


Ile Gly Ser Asn Ala Leu Arg Met Ile Gln Ser Ala Thr Pro Pro Pro 
    290                 295                 300                 


Pro Thr Thr Arg Pro Pro Pro Ile Arg Pro Pro Phe Ser His Pro Ile 
305                 310                 315                 320 


Ser Ala His Leu Pro Trp Tyr Phe Gln Pro Pro Pro Arg Pro Leu Pro 
                325                 330                 335     


Pro Arg Pro Pro Ala Ala Gln Pro Arg Pro Pro Pro Ser Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Pro Ala Ser Pro Leu Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Pro Thr Pro Ser Ser Thr Thr Lys Leu Pro Gln Gly Leu Ser Phe 
    370                 375                 380                 


Ala Lys Arg Leu Gln Gln Leu Ile Glu Val Leu Lys Gly Lys Thr Tyr 
385                 390                 395                 400 


Ser Asp Gly Lys Asn His Tyr Asp Met Glu Thr Thr Glu Leu Pro Glu 
                405                 410                 415     


Leu Thr Ser Thr Ser 
            420     


<210> 76
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Thr Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Thr Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Thr Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Thr Cys Thr 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu Pro Gln Gln Asp Phe 
                165                 170                 175     


Ala Lys Tyr Ile Glu Met His Val Ile Val Glu Lys Gln Leu Tyr Asn 
            180                 185                 190         


His Met Gly Ser Asp Thr Thr Val Val Ala Gln Lys Val Phe Gln Leu 
        195                 200                 205             


Ile Gly Leu Thr Asn Ala Ile Phe Val Ser Phe Asn Ile Thr Ile Ile 
    210                 215                 220                 


Leu Ser Ser Leu Glu Leu Trp Ile Asp Glu Asn Lys Ile Ala Thr Thr 
225                 230                 235                 240 


Gly Glu Ala Asn Glu Leu Leu His Thr Phe Leu Arg Trp Lys Thr Ser 
                245                 250                 255     


Tyr Leu Val Leu Arg Pro His Asp Val Ala Phe Leu Leu Val Tyr Arg 
            260                 265                 270         


Glu Lys Ser Asn Tyr Val Gly Ala Thr Phe Gln Gly Lys Met Cys Asp 
        275                 280                 285             


Ala Asn Tyr Ala Gly Gly Val Val Leu His Pro Arg Thr Ile Ser Leu 
    290                 295                 300                 


Glu Ser Leu Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser Met Gly 
305                 310                 315                 320 


Ile Thr Tyr Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala Val Cys 
                325                 330                 335     


Ile Met Asn Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile Phe Ser 
            340                 345                 350         


Asn Cys Ser Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln Lys Ser 
        355                 360                 365             


Gln Cys Leu His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys Gln Gln 
    370                 375                 380                 


Ala Val Cys Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys Asp Cys 
385                 390                 395                 400 


Gly Thr Glu Gln Asp Cys Ala Leu Ile Gly Glu Thr Cys Cys Asp Ile 
                405                 410                 415     


Ala Thr Cys Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly Pro Cys 
            420                 425                 430         


Cys Glu Asn Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg Pro Ser 
        435                 440                 445             


Phe Glu Glu Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser Ala Ser 
    450                 455                 460                 


Cys Pro Glu Asn His Tyr Val Gln Thr Gly His Pro Cys Gly Leu Asn 
465                 470                 475                 480 


Gln Trp Ile Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys Gln Cys 
                485                 490                 495     


Thr Asp Thr Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu Cys Tyr 
            500                 505                 510         


Ser His Leu Asn Ser Lys Thr Asp Val Ser Gly Asn Cys Gly Ile Ser 
        515                 520                 525             


Asp Ser Gly Tyr Thr Gln Cys Glu Ala Asp Asn Leu Gln Cys Gly Lys 
    530                 535                 540                 


Leu Ile Cys Lys Tyr Val Gly Lys Phe Leu Leu Gln Ile Pro Arg Ala 
545                 550                 555                 560 


Thr Ile Ile Tyr Ala Asn Ile Ser Gly His Leu Cys Ile Ala Val Glu 
                565                 570                 575     


Phe Ala Ser Asp His Ala Asp Ser Gln Lys Met Trp Ile Lys Asp Gly 
            580                 585                 590         


Thr Ser Cys Gly Ser Asn Lys Val Cys Arg Asn Gln Arg Cys Val Ser 
        595                 600                 605             


Ser Ser Tyr Leu Gly Tyr Asp Cys Thr Thr Asp Lys Cys Asn Asp Arg 
    610                 615                 620                 


Gly Val Cys Asn Asn Lys Lys His Cys His Cys Ser Ala Ser Tyr Leu 
625                 630                 635                 640 


Pro Pro Asp Cys Ser Val Gln Ser Asp Leu Trp Pro Gly Gly Ser Ile 
                645                 650                 655     


Asp Ser Gly Asn Phe Pro Pro Val Ala Ile Pro Ala Arg Leu Pro Glu 
            660                 665                 670         


Arg Arg Tyr Ile Glu Asn Ile Tyr His Ser Lys Pro Met Arg Trp Pro 
        675                 680                 685             


Phe Phe Leu Phe Ile Pro Phe Phe Ile Ile Phe Cys Val Leu Ile Ala 
    690                 695                 700                 


Ile Met Val Lys Val Asn Phe Gln Arg Lys Lys Trp Arg Thr Glu Asp 
705                 710                 715                 720 


Tyr Ser Ser Asp Glu Gln Pro Glu Ser Glu Ser Glu Pro Lys Gly 
                725                 730                 735 


<210> 77
<211> 678
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Met Trp Lys Leu Leu Leu Trp Val Gly Leu Val Leu Val Leu Lys His 
1               5                   10                  15      


His Asp Gly Ala Ala His Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


His Ser Arg Pro Gly Pro Ala Ser Ile Leu Pro His Asp Leu Asp Pro 
        35                  40                  45              


Phe Leu Cys Thr His Leu Ile Phe Ala Phe Ala Ser Met Asn Asn Asn 
    50                  55                  60                  


Gln Ile Val Ala Lys Asp Leu Gln Asp Glu Lys Ile Leu Tyr Pro Glu 
65                  70                  75                  80  


Phe Asn Lys Leu Lys Glu Arg Asn Arg Glu Leu Lys Thr Leu Leu Ser 
                85                  90                  95      


Ile Gly Gly Trp Asn Phe Gly Thr Ser Arg Phe Thr Thr Met Leu Ser 
            100                 105                 110         


Thr Phe Ala Asn Arg Glu Lys Phe Ile Ala Ser Val Ile Ser Leu Leu 
        115                 120                 125             


Arg Thr His Asp Phe Asp Gly Leu Asp Leu Phe Phe Leu Tyr Pro Gly 
    130                 135                 140                 


Leu Arg Gly Ser Pro Met His Asp Arg Trp Thr Phe Leu Phe Leu Ile 
145                 150                 155                 160 


Glu Glu Leu Leu Phe Ala Phe Arg Lys Glu Ala Leu Leu Thr Met Arg 
                165                 170                 175     


Pro Arg Leu Leu Leu Ser Ala Ala Val Ser Gly Val Pro His Ile Val 
            180                 185                 190         


Gln Thr Ser Tyr Asp Val Arg Phe Leu Gly Arg Leu Leu Asp Phe Ile 
        195                 200                 205             


Asn Val Leu Ser Tyr Asp Leu His Gly Ser Trp Glu Arg Phe Thr Gly 
    210                 215                 220                 


His Asn Ser Pro Leu Phe Ser Leu Pro Glu Asp Pro Lys Ser Ser Ala 
225                 230                 235                 240 


Tyr Ala Met Asn Tyr Trp Arg Lys Leu Gly Ala Pro Ser Glu Lys Leu 
                245                 250                 255     


Ile Met Gly Ile Pro Thr Tyr Gly Arg Thr Phe Arg Leu Leu Lys Ala 
            260                 265                 270         


Ser Lys Asn Gly Leu Gln Ala Arg Ala Ile Gly Pro Ala Ser Pro Gly 
        275                 280                 285             


Lys Tyr Thr Lys Gln Glu Gly Phe Leu Ala Tyr Phe Glu Ile Cys Ser 
    290                 295                 300                 


Phe Val Trp Gly Ala Lys Lys His Trp Ile Asp Tyr Gln Tyr Val Pro 
305                 310                 315                 320 


Tyr Ala Asn Lys Gly Lys Glu Trp Val Gly Tyr Asp Asn Ala Ile Ser 
                325                 330                 335     


Phe Ser Tyr Lys Ala Trp Phe Ile Arg Arg Glu His Phe Gly Gly Ala 
            340                 345                 350         


Met Val Trp Thr Leu Asp Met Asp Asp Val Arg Gly Thr Phe Cys Gly 
        355                 360                 365             


Thr Gly Pro Phe Pro Leu Val Tyr Val Leu Asn Asp Ile Leu Val Arg 
    370                 375                 380                 


Ala Glu Phe Ser Ser Thr Ser Leu Pro Gln Phe Trp Leu Ser Ser Ala 
385                 390                 395                 400 


Val Asn Ser Ser Ser Thr Asp Pro Glu Arg Leu Ala Val Thr Thr Ala 
                405                 410                 415     


Trp Thr Thr Asp Ser Lys Ile Leu Pro Pro Gly Gly Glu Ala Gly Val 
            420                 425                 430         


Thr Glu Ile His Gly Lys Cys Glu Asn Met Thr Ile Thr Pro Arg Gly 
        435                 440                 445             


Thr Thr Val Thr Pro Thr Lys Glu Thr Val Ser Leu Gly Lys His Thr 
    450                 455                 460                 


Val Ala Leu Gly Glu Lys Thr Glu Ile Thr Gly Ala Met Thr Met Thr 
465                 470                 475                 480 


Ser Val Gly His Gln Ser Met Thr Pro Gly Glu Lys Ala Leu Thr Pro 
                485                 490                 495     


Val Gly His Gln Ser Val Thr Thr Gly Gln Lys Thr Leu Thr Ser Val 
            500                 505                 510         


Gly Tyr Gln Ser Val Thr Pro Gly Glu Lys Thr Leu Thr Pro Val Gly 
        515                 520                 525             


His Gln Ser Val Thr Pro Val Ser His Gln Ser Val Ser Pro Gly Gly 
    530                 535                 540                 


Thr Thr Met Thr Pro Val His Phe Gln Thr Glu Thr Leu Arg Gln Asn 
545                 550                 555                 560 


Thr Val Ala Pro Arg Arg Lys Ala Val Ala Arg Glu Lys Val Thr Val 
                565                 570                 575     


Pro Ser Arg Asn Ile Ser Val Thr Pro Glu Gly Gln Thr Met Pro Leu 
            580                 585                 590         


Arg Gly Glu Asn Leu Thr Ser Glu Val Gly Thr His Pro Arg Met Gly 
        595                 600                 605             


Asn Leu Gly Leu Gln Met Glu Ala Glu Asn Arg Met Met Leu Ser Ser 
    610                 615                 620                 


Ser Pro Val Ile Gln Leu Pro Glu Gln Thr Pro Leu Ala Phe Asp Asn 
625                 630                 635                 640 


Arg Phe Val Pro Ile Tyr Gly Asn His Ser Ser Val Asn Ser Val Thr 
                645                 650                 655     


Pro Gln Thr Ser Pro Leu Ser Leu Lys Lys Glu Ile Pro Glu Asn Ser 
            660                 665                 670         


Ala Val Asp Glu Glu Ala 
        675             


<210> 78
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala 
1               5                   10                  15      


Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly 
            20                  25                  30          


Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser 
        35                  40                  45              


Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp 
    50                  55                  60                  


Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly 
                85                  90                  95      


Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr 
            100                 105                 110         


His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg 
        115                 120                 125             


Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe His Lys 
145                 150                 155                 160 


Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met 
                165                 170                 175     


Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu 
            180                 185                 190         


His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys 
        195                 200                 205             


Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys 
    210                 215                 220                 


Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val 
225                 230                 235                 240 


Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala 
                245                 250                 255     


Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile 
            260                 265                 270         


Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr 
        275                 280                 285             


Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp 
    290                 295                 300                 


Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met 
305                 310                 315                 320 


Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn 
                325                 330                 335     


Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys 
            340                 345                 350         


Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu 
        355                 360                 365             


Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys 
    370                 375                 380                 


Cys Gly Asp Arg Pro Gly Leu Leu Asn Val Gly His Ile Glu Lys Met 
385                 390                 395                 400 


Gln Glu Gly Ile Val His Val Leu Arg Leu His Leu Gln Ser Asn His 
                405                 410                 415     


Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp 
            420                 425                 430         


Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val Gln Ile Ile Lys 
        435                 440                 445             


Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu Gln Glu Ile Tyr 
    450                 455                 460                 


Arg Asp Met Tyr 
465             


<210> 79
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210> 80
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser Gly His 
            260                 265                 270         


Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser Val Asn 
        275                 280                 285             


Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr Arg Gly Val Arg Pro 
    290                 295                 300                 


Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys 
305                 310                 315                 320 


Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp 
                325                 330                 335     


Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln 
            340                 345                 350         


Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val Asp Ser Gly 
        355                 360                 365             


Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser Ala Trp Asp 
    370                 375                 380                 


Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser Trp Asp Arg 
385                 390                 395                 400 


Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro 
                405                 410                 415     


Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys 
            420                 425                 430         


Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp 
        435                 440                 445             


Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val Pro Gly Gly 
    450                 455                 460                 


Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala 
                485                 490                 495     


Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg 
            500                 505                 510         


Thr Leu Gly His Tyr Met Ala Arg 
        515                 520 


<210> 81
<211> 325
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe 
                245                 250                 255     


Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His 
            260                 265                 270         


Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu 
        275                 280                 285             


Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser 
    290                 295                 300                 


Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly 
305                 310                 315                 320 


Gln Gly Pro Gln Ser 
                325 


<210> 82
<211> 689
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Lys Ile 
            20                  25                  30          


Leu Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Glu 
        35                  40                  45              


Asp Arg Gly Glu Val Thr Phe Glu Lys Ile Phe Ser Gln Lys Leu Gly 
    50                  55                  60                  


Tyr Leu Leu Phe Arg Asp Phe Cys Leu Asn His Leu Glu Glu Ala Arg 
65                  70                  75                  80  


Pro Leu Val Glu Phe Tyr Glu Glu Ile Lys Lys Tyr Glu Lys Leu Glu 
                85                  90                  95      


Thr Glu Glu Glu Arg Val Ala Arg Ser Arg Glu Ile Phe Asp Ser Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ala Cys Ser His Pro Phe Ser Lys Ser Ala 
        115                 120                 125             


Thr Glu His Val Gln Gly His Leu Gly Lys Lys Gln Val Pro Pro Asp 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Gln Asn Leu Arg Gly Asp 
145                 150                 155                 160 


Val Phe Gln Lys Phe Ile Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Asp Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Ser Tyr Ala Phe His Thr Pro Asp Lys Leu Ser Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Ala Asp Met Arg Phe Tyr Ala Ala Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Val Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Val Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Met Ala Val Glu Leu Pro Asp Ser 
                405                 410                 415     


Phe Ser Pro Glu Leu Arg Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Asn Arg Arg Leu Gly Cys Leu Gly Arg Gly Ala Gln Glu Val Lys 
        435                 440                 445             


Glu Ser Pro Phe Phe Arg Ser Leu Asp Trp Gln Met Val Phe Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Ser Asp Gln Glu Leu Tyr Arg Asn Phe Pro Leu Thr 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Ala Glu Thr Val Phe Asp Thr 
        515                 520                 525             


Ile Asn Ala Glu Thr Asp Arg Leu Glu Ala Arg Lys Lys Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Ser Lys Met Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ala Pro Gln Ser Leu Leu Thr Met Glu Glu Ile Gln Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Glu Arg Lys Cys Leu Leu Leu Lys Ile 
    610                 615                 620                 


Arg Gly Gly Lys Gln Phe Ile Leu Gln Cys Asp Ser Asp Pro Glu Leu 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Arg Asp Ala Tyr Arg Glu Ala Gln Gln 
                645                 650                 655     


Leu Val Gln Arg Val Pro Lys Met Lys Asn Lys Pro Arg Ser Pro Val 
            660                 665                 670         


Val Glu Leu Ser Lys Val Pro Leu Val Gln Arg Gly Ser Ala Asn Gly 
        675                 680                 685             


Leu 
    


<210> 83
<211> 524
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 
            260                 265                 270         


Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 
        275                 280                 285             


Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 
    290                 295                 300                 


His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 
305                 310                 315                 320 


Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 
                325                 330                 335     


Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 
            340                 345                 350         


Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 
        355                 360                 365             


Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 
    370                 375                 380                 


Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 
385                 390                 395                 400 


Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 
                405                 410                 415     


Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 
            420                 425                 430         


Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 
        435                 440                 445             


Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 
    450                 455                 460                 


Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 
465                 470                 475                 480 


Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 
                485                 490                 495     


Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 
            500                 505                 510         


Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 


<210> 84
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Ala Lys Met Asn Leu Ser Ser Tyr Ile Leu Ile Leu Thr Phe Ser 
1               5                   10                  15      


Leu Phe Ser Gln Gly Ile Leu Leu Ser Ala Ser Lys Ser Ile Arg Asn 
            20                  25                  30          


Leu Asp Asp Asp Met Val Phe Asn Thr Phe Arg Leu Gly Lys Gly Phe 
        35                  40                  45              


Gln Lys Glu Asp Thr Ala Glu Lys Ser Val Ile Ala Pro Ser Leu Glu 
    50                  55                  60                  


Gln Tyr Lys Asn Asp Glu Ser Ser Phe Met Asn Glu Glu Glu Asn Lys 
65                  70                  75                  80  


Val Ser Lys Asn Thr Gly Ser Lys His Asn Phe Leu Asn His Gly Leu 
                85                  90                  95      


Pro Leu Asn Leu Ala Ile Lys Pro Tyr Leu Ala Leu Lys Gly Ser Val 
            100                 105                 110         


Ala Phe Pro Ala Glu Asn Gly Val Gln Asn Thr Glu Ser Thr Gln Glu 
        115                 120                 125             


Lys Arg Glu Ile Gly Asp Glu Glu Asn Ser Ala Lys Phe Pro Ile Gly 
    130                 135                 140                 


Arg Arg Asp Phe Asp Met Leu Arg Cys Met Leu Gly Arg Val Tyr Arg 
145                 150                 155                 160 


Pro Cys Trp Gln Val 
                165 


<210> 85
<211> 1609
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210> 86
<211> 1798
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Met Glu Leu Thr Ser Arg Glu Arg Gly Arg Gly Gln Pro Leu Pro Trp 
1               5                   10                  15      


Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala Thr Leu Ala 
            20                  25                  30          


Gln Ala Pro Ala Pro Asp Val Pro Gly Cys Ser Arg Gly Ser Cys Tyr 
        35                  40                  45              


Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg Leu Thr Ala 
    50                  55                  60                  


Ser Ser Thr Cys Gly Leu Asn Gly Pro Gln Pro Tyr Cys Ile Val Ser 
65                  70                  75                  80  


His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser Arg Arg Pro 
                85                  90                  95      


Phe Ser Ala Arg Asp Asn Pro His Ser His Arg Ile Gln Asn Val Val 
            100                 105                 110         


Thr Ser Phe Ala Pro Gln Arg Arg Ala Ala Trp Trp Gln Ser Glu Asn 
        115                 120                 125             


Gly Ile Pro Ala Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His 
    130                 135                 140                 


Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met 
145                 150                 155                 160 


Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg 
                165                 170                 175     


Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala 
            180                 185                 190         


Pro Pro Arg His Trp Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu 
        195                 200                 205             


Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro 
    210                 215                 220                 


Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu 
225                 230                 235                 240 


Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly 
                245                 250                 255     


Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His 
        275                 280                 285             


Ala Ser Glu Cys Ala Pro Ala Pro Gly Ala Pro Ala His Ala Glu Gly 
    290                 295                 300                 


Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg Gly Leu Asn 
305                 310                 315                 320 


Cys Glu Gln Cys Gln Asp Phe Tyr Arg Asp Leu Pro Trp Arg Pro Ala 
                325                 330                 335     


Glu Asp Gly His Ser His Ala Cys Arg Lys Cys Glu Cys His Gly His 
            340                 345                 350         


Thr His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala Ser Gly Asn 
        355                 360                 365             


Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr Ala Gly Arg 
    370                 375                 380                 


His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro Thr Lys Asp 
385                 390                 395                 400 


Leu Arg Asp Pro Ala Val Cys Arg Ser Cys Asp Cys Asp Pro Met Gly 
                405                 410                 415     


Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro Ala Leu Gly 
            420                 425                 430         


Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val Gly Thr Arg 
        435                 440                 445             


Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ile Ser Asp Arg 
    450                 455                 460                 


Leu Gly Cys Arg Arg Cys Gln Cys Asn Ala Arg Gly Thr Val Pro Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asp Pro Asn Ser Gly Ser Cys Tyr Cys Lys Arg Leu 
                485                 490                 495     


Val Thr Gly Arg Gly Cys Asp Arg Cys Leu Pro Gly His Trp Gly Leu 
            500                 505                 510         


Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp Val Gly Gly 
        515                 520                 525             


Ala Leu Asp Pro Gln Cys Asp Glu Gly Thr Gly Gln Cys His Cys Arg 
    530                 535                 540                 


Gln His Met Val Gly Arg Arg Cys Glu Gln Val Gln Pro Gly Tyr Phe 
545                 550                 555                 560 


Arg Pro Phe Leu Asp His Leu Ile Trp Glu Ala Glu Asp Thr Arg Gly 
                565                 570                 575     


Gln Val Leu Asp Val Val Glu Arg Leu Val Thr Pro Gly Glu Thr Pro 
            580                 585                 590         


Ser Trp Thr Gly Ser Gly Phe Val Arg Leu Gln Glu Gly Gln Thr Leu 
        595                 600                 605             


Glu Phe Leu Val Ala Ser Val Pro Lys Ala Met Asp Tyr Asp Leu Leu 
    610                 615                 620                 


Leu Arg Leu Glu Pro Gln Val Pro Glu Gln Trp Ala Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Val Gln Arg Pro Gly Pro Val Pro Ala His Ser Leu Cys Gly His 
                645                 650                 655     


Leu Val Pro Lys Asp Asp Arg Ile Gln Gly Thr Leu Gln Pro His Ala 
            660                 665                 670         


Arg Tyr Leu Ile Phe Pro Asn Pro Val Cys Leu Glu Pro Gly Ile Ser 
        675                 680                 685             


Tyr Lys Leu His Leu Lys Leu Val Arg Thr Gly Gly Ser Ala Gln Pro 
    690                 695                 700                 


Glu Thr Pro Tyr Ser Gly Pro Gly Leu Leu Ile Asp Ser Leu Val Leu 
705                 710                 715                 720 


Leu Pro Arg Val Leu Val Leu Glu Met Phe Ser Gly Gly Asp Ala Ala 
                725                 730                 735     


Ala Leu Glu Arg Gln Ala Thr Phe Glu Arg Tyr Gln Cys His Glu Glu 
            740                 745                 750         


Gly Leu Val Pro Ser Lys Thr Ser Pro Ser Glu Ala Cys Ala Pro Leu 
        755                 760                 765             


Leu Ile Ser Leu Ser Thr Leu Ile Tyr Asn Gly Ala Leu Pro Cys Gln 
    770                 775                 780                 


Cys Asn Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro His Gly Gly 
785                 790                 795                 800 


Gln Cys Leu Cys Lys Pro Gly Val Val Gly Arg Arg Cys Asp Leu Cys 
                805                 810                 815     


Ala Pro Gly Tyr Tyr Gly Phe Gly Pro Thr Gly Cys Gln Ala Cys Gln 
            820                 825                 830         


Cys Ser His Glu Gly Ala Leu Ser Ser Leu Cys Glu Lys Thr Ser Gly 
        835                 840                 845             


Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys Asp Arg Cys 
    850                 855                 860                 


Gln Arg Gly Gln Trp Gly Phe Pro Ser Cys Arg Pro Cys Val Cys Asn 
865                 870                 875                 880 


Gly His Ala Asp Glu Cys Asn Thr His Thr Gly Ala Cys Leu Gly Cys 
                885                 890                 895     


Arg Asp His Thr Gly Gly Glu His Cys Glu Arg Cys Ile Ala Gly Phe 
            900                 905                 910         


His Gly Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg Pro Cys Pro 
        915                 920                 925             


Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr Ser Cys His 
    930                 935                 940                 


Gln Asp Glu Tyr Ser Gln Gln Ile Val Cys His Cys Arg Ala Gly Tyr 
945                 950                 955                 960 


Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe Gly Asp Pro 
                965                 970                 975     


Ser Arg Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser Gly Asn Ile 
            980                 985                 990         


Asp Pro Met Asp Pro Asp Ala Cys  Asp Pro His Thr Gly  Gln Cys Leu 
        995                 1000                 1005             


Arg Cys  Leu His His Thr Glu  Gly Pro His Cys Ala  His Cys Lys 
    1010                 1015                 1020             


Pro Gly  Phe His Gly Gln Ala  Ala Arg Gln Ser Cys  His Arg Cys 
    1025                 1030                 1035             


Thr Cys  Asn Leu Leu Gly Thr  Asn Pro Gln Gln Cys  Pro Ser Pro 
    1040                 1045                 1050             


Asp Gln  Cys His Cys Asp Pro  Ser Ser Gly Gln Cys  Pro Cys Leu 
    1055                 1060                 1065             


Pro Asn  Val Gln Gly Pro Ser  Cys Asp Arg Cys Ala  Pro Asn Phe 
    1070                 1075                 1080             


Trp Asn  Leu Thr Ser Gly His  Gly Cys Gln Pro Cys  Ala Cys His 
    1085                 1090                 1095             


Pro Ser  Arg Ala Arg Gly Pro  Thr Cys Asn Glu Phe  Thr Gly Gln 
    1100                 1105                 1110             


Cys His  Cys Arg Ala Gly Phe  Gly Gly Arg Thr Cys  Ser Glu Cys 
    1115                 1120                 1125             


Gln Glu  Leu His Trp Gly Asp  Pro Gly Leu Gln Cys  His Ala Cys 
    1130                 1135                 1140             


Asp Cys  Asp Ser Arg Gly Ile  Asp Thr Pro Gln Cys  His Arg Phe 
    1145                 1150                 1155             


Thr Gly  His Cys Ser Cys Arg  Pro Gly Val Ser Gly  Val Arg Cys 
    1160                 1165                 1170             


Asp Gln  Cys Ala Arg Gly Phe  Ser Gly Ile Phe Pro  Ala Cys His 
    1175                 1180                 1185             


Pro Cys  His Ala Cys Phe Gly  Asp Trp Asp Arg Val  Val Gln Asp 
    1190                 1195                 1200             


Leu Ala  Ala Arg Thr Gln Arg  Leu Glu Gln Arg Ala  Gln Glu Leu 
    1205                 1210                 1215             


Gln Gln  Thr Gly Val Leu Gly  Ala Phe Glu Ser Ser  Phe Trp His 
    1220                 1225                 1230             


Met Gln  Glu Lys Leu Gly Ile  Val Gln Gly Ile Val  Gly Ala Arg 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Ser Thr  Ala Gln Leu Val Glu  Ala Thr Glu 
    1250                 1255                 1260             


Glu Leu  Arg Arg Glu Ile Gly  Glu Ala Thr Glu His  Leu Thr Gln 
    1265                 1270                 1275             


Leu Glu  Ala Asp Leu Thr Asp  Val Gln Asp Glu Asn  Phe Asn Ala 
    1280                 1285                 1290             


Asn His  Ala Leu Ser Gly Leu  Glu Arg Asp Arg Leu  Ala Leu Asn 
    1295                 1300                 1305             


Leu Thr  Leu Arg Gln Leu Asp  Gln His Leu Asp Leu  Leu Lys His 
    1310                 1315                 1320             


Ser Asn  Phe Leu Gly Ala Tyr  Asp Ser Ile Arg His  Ala His Ser 
    1325                 1330                 1335             


Gln Ser  Ala Glu Ala Glu Arg  Arg Ala Asn Thr Ser  Ala Leu Ala 
    1340                 1345                 1350             


Val Pro  Ser Pro Val Ser Asn  Ser Ala Ser Ala Arg  His Arg Thr 
    1355                 1360                 1365             


Glu Ala  Leu Met Asp Ala Gln  Lys Glu Asp Phe Asn  Ser Lys His 
    1370                 1375                 1380             


Met Ala  Asn Gln Arg Ala Leu  Gly Lys Leu Ser Ala  His Thr His 
    1385                 1390                 1395             


Thr Leu  Ser Leu Thr Asp Ile  Asn Glu Leu Val Cys  Gly Ala Pro 
    1400                 1405                 1410             


Gly Asp  Ala Pro Cys Ala Thr  Ser Pro Cys Gly Gly  Ala Gly Cys 
    1415                 1420                 1425             


Arg Asp  Glu Asp Gly Gln Pro  Arg Cys Gly Gly Leu  Ser Cys Asn 
    1430                 1435                 1440             


Gly Ala  Ala Ala Thr Ala Asp  Leu Ala Leu Gly Arg  Ala Arg His 
    1445                 1450                 1455             


Thr Gln  Ala Glu Leu Gln Arg  Ala Leu Ala Glu Gly  Gly Ser Ile 
    1460                 1465                 1470             


Leu Ser  Arg Val Ala Glu Thr  Arg Arg Gln Ala Ser  Glu Ala Gln 
    1475                 1480                 1485             


Gln Arg  Ala Gln Ala Ala Leu  Asp Lys Ala Asn Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gln Val  Glu Gln Ala Asn Gln  Glu Leu Gln Glu Leu  Ile Gln Ser 
    1505                 1510                 1515             


Val Lys  Asp Phe Leu Asn Gln  Glu Gly Ala Asp Pro  Asp Ser Ile 
    1520                 1525                 1530             


Glu Met  Val Ala Thr Arg Val  Leu Glu Leu Ser Ile  Pro Ala Ser 
    1535                 1540                 1545             


Ala Glu  Gln Ile Gln His Leu  Ala Gly Ala Ile Ala  Glu Arg Val 
    1550                 1555                 1560             


Arg Ser  Leu Ala Asp Val Asp  Ala Ile Leu Ala Arg  Thr Val Gly 
    1565                 1570                 1575             


Asp Val  Arg Arg Ala Glu Gln  Leu Leu Gln Asp Ala  Arg Arg Ala 
    1580                 1585                 1590             


Arg Ser  Trp Ala Glu Asp Glu  Lys Gln Lys Ala Glu  Thr Val Gln 
    1595                 1600                 1605             


Ala Ala  Leu Glu Glu Ala Gln  Arg Ala Gln Gly Ile  Ala Gln Gly 
    1610                 1615                 1620             


Ala Ile  Arg Gly Ala Val Ala  Asp Thr Arg Asp Thr  Glu Gln Thr 
    1625                 1630                 1635             


Leu Tyr  Gln Val Gln Glu Arg  Met Ala Gly Ala Glu  Arg Ala Leu 
    1640                 1645                 1650             


Ser Ser  Ala Gly Glu Arg Ala  Arg Gln Leu Asp Ala  Leu Leu Glu 
    1655                 1660                 1665             


Ala Leu  Lys Leu Lys Arg Ala  Gly Asn Ser Leu Ala  Ala Ser Thr 
    1670                 1675                 1680             


Ala Glu  Glu Thr Ala Gly Ser  Ala Gln Gly Arg Ala  Gln Glu Ala 
    1685                 1690                 1695             


Glu Gln  Leu Leu Arg Gly Pro  Leu Gly Asp Gln Tyr  Gln Thr Val 
    1700                 1705                 1710             


Lys Ala  Leu Ala Glu Arg Lys  Ala Gln Gly Val Leu  Ala Ala Gln 
    1715                 1720                 1725             


Ala Arg  Ala Glu Gln Leu Arg  Asp Glu Ala Arg Asp  Leu Leu Gln 
    1730                 1735                 1740             


Ala Ala  Gln Asp Lys Leu Gln  Arg Leu Gln Glu Leu  Glu Gly Thr 
    1745                 1750                 1755             


Tyr Glu  Glu Asn Glu Arg Ala  Leu Glu Ser Lys Ala  Ala Gln Leu 
    1760                 1765                 1770             


Asp Gly  Leu Glu Ala Arg Met  Arg Ser Val Leu Gln  Ala Ile Asn 
    1775                 1780                 1785             


Leu Gln  Val Gln Ile Tyr Asn  Thr Cys Gln 
    1790                 1795             


<210> 87
<211> 1786
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn 
65                  70                  75                  80  


Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile 
                85                  90                  95      


Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp 
            100                 105                 110         


Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu 
        115                 120                 125             


Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg 
    130                 135                 140                 


Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp 
145                 150                 155                 160 


Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly 
                165                 170                 175     


Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser 
            180                 185                 190         


Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg 
        195                 200                 205             


Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile 
    210                 215                 220                 


Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu 
225                 230                 235                 240 


His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu 
                245                 250                 255     


Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe 
            260                 265                 270         


Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Phe Asn Glu 
        275                 280                 285             


Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr 
    290                 295                 300                 


Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn 
                325                 330                 335     


Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala Val Tyr Leu 
            340                 345                 350         


Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn 
        355                 360                 365             


Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Tyr Gln His 
    370                 375                 380                 


Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu Arg Cys Thr Cys 
385                 390                 395                 400 


Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp Ser Tyr Thr Asp 
                405                 410                 415     


Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu Asn Val 
            420                 425                 430         


Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser 
        435                 440                 445             


Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly 
    450                 455                 460                 


Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly His Cys Tyr 
465                 470                 475                 480 


Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln Cys Leu Pro Glu 
                485                 490                 495     


His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys 
            500                 505                 510         


Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala Glu Ser Gly Gln 
        515                 520                 525             


Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu 
    530                 535                 540                 


Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu Tyr Glu Ala Glu 
545                 550                 555                 560 


Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu Arg Gln Tyr Ile 
                565                 570                 575     


Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe Val Arg Val Pro 
            580                 585                 590         


Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met 
        595                 600                 605             


Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp 
    610                 615                 620                 


Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg Ile Pro Thr Ser 
625                 630                 635                 640 


Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn Gln Val Val Ser 
                645                 650                 655     


Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe 
            660                 665                 670         


Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr 
        675                 680                 685             


Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu Ile Asp Ser Leu 
    690                 695                 700                 


Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly 
705                 710                 715                 720 


Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg 
                725                 730                 735     


Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr 
            740                 745                 750         


Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Leu His Gln 
        755                 760                 765             


Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val 
    770                 775                 780                 


Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly 
785                 790                 795                 800 


Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Ser 
                805                 810                 815     


Gly Cys Lys Pro Cys Glu Cys His Leu Gln Gly Ser Val Asn Ala Phe 
            820                 825                 830         


Cys Asn Pro Val Thr Gly Gln Cys His Cys Phe Gln Gly Val Tyr Ala 
        835                 840                 845             


Arg Gln Cys Asp Arg Cys Leu Pro Gly His Trp Gly Phe Pro Ser Cys 
    850                 855                 860                 


Gln Pro Cys Gln Cys Asn Gly His Ala Asp Asp Cys Asp Pro Val Thr 
865                 870                 875                 880 


Gly Glu Cys Leu Asn Cys Gln Asp Tyr Thr Met Gly His Asn Cys Glu 
                885                 890                 895     


Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile Gly Ser Gly Asp 
            900                 905                 910         


His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp Ser Gly Arg Gln 
        915                 920                 925             


Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu Gln Leu Ala Cys 
    930                 935                 940                 


Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp Asp Cys Ala Ser 
945                 950                 955                 960 


Gly Tyr Phe Gly Asn Pro Ser Glu Val Gly Gly Ser Cys Gln Pro Cys 
                965                 970                 975     


Gln Cys His Asn Asn Ile Asp Thr Thr Asp Pro Glu Ala Cys Asp Lys 
            980                 985                 990         


Glu Thr Gly Arg Cys Leu Lys Cys  Leu Tyr His Thr Glu  Gly Glu His 
        995                 1000                 1005             


Cys Gln  Phe Cys Arg Phe Gly  Tyr Tyr Gly Asp Ala  Leu Gln Gln 
    1010                 1015                 1020             


Asp Cys  Arg Lys Cys Val Cys  Asn Tyr Leu Gly Thr  Val Gln Glu 
    1025                 1030                 1035             


His Cys  Asn Gly Ser Asp Cys  Gln Cys Asp Lys Ala  Thr Gly Gln 
    1040                 1045                 1050             


Cys Leu  Cys Leu Pro Asn Val  Ile Gly Gln Asn Cys  Asp Arg Cys 
    1055                 1060                 1065             


Ala Pro  Asn Thr Trp Gln Leu  Ala Ser Gly Thr Gly  Cys Asp Pro 
    1070                 1075                 1080             


Cys Asn  Cys Asn Ala Ala His  Ser Phe Gly Pro Ser  Cys Asn Glu 
    1085                 1090                 1095             


Phe Thr  Gly Gln Cys Gln Cys  Met Pro Gly Phe Gly  Gly Arg Thr 
    1100                 1105                 1110             


Cys Ser  Glu Cys Gln Glu Leu  Phe Trp Gly Asp Pro  Asp Val Glu 
    1115                 1120                 1125             


Cys Arg  Ala Cys Asp Cys Asp  Pro Arg Gly Ile Glu  Thr Pro Gln 
    1130                 1135                 1140             


Cys Asp  Gln Ser Thr Gly Gln  Cys Val Cys Val Glu  Gly Val Glu 
    1145                 1150                 1155             


Gly Pro  Arg Cys Asp Lys Cys  Thr Arg Gly Tyr Ser  Gly Val Phe 
    1160                 1165                 1170             


Pro Asp  Cys Thr Pro Cys His  Gln Cys Phe Ala Leu  Trp Asp Val 
    1175                 1180                 1185             


Ile Ile  Ala Glu Leu Thr Asn  Arg Thr His Arg Phe  Leu Glu Lys 
    1190                 1195                 1200             


Ala Lys  Ala Leu Lys Ile Ser  Gly Val Ile Gly Pro  Tyr Arg Glu 
    1205                 1210                 1215             


Thr Val  Asp Ser Val Glu Arg  Lys Val Ser Glu Ile  Lys Asp Ile 
    1220                 1225                 1230             


Leu Ala  Gln Ser Pro Ala Ala  Glu Pro Leu Lys Asn  Ile Gly Asn 
    1235                 1240                 1245             


Leu Phe  Glu Glu Ala Glu Lys  Leu Ile Lys Asp Val  Thr Glu Met 
    1250                 1255                 1260             


Met Ala  Gln Val Glu Val Lys  Leu Ser Asp Thr Thr  Ser Gln Ser 
    1265                 1270                 1275             


Asn Ser  Thr Ala Lys Glu Leu  Asp Ser Leu Gln Thr  Glu Ala Glu 
    1280                 1285                 1290             


Ser Leu  Asp Asn Thr Val Lys  Glu Leu Ala Glu Gln  Leu Glu Phe 
    1295                 1300                 1305             


Ile Lys  Asn Ser Asp Ile Arg  Gly Ala Leu Asp Ser  Ile Thr Lys 
    1310                 1315                 1320             


Tyr Phe  Gln Met Ser Leu Glu  Ala Glu Glu Arg Val  Asn Ala Ser 
    1325                 1330                 1335             


Thr Thr  Glu Pro Asn Ser Thr  Val Glu Gln Ser Ala  Leu Met Arg 
    1340                 1345                 1350             


Asp Arg  Val Glu Asp Val Met  Met Glu Arg Glu Ser  Gln Phe Lys 
    1355                 1360                 1365             


Glu Lys  Gln Glu Glu Gln Ala  Arg Leu Leu Asp Glu  Leu Ala Gly 
    1370                 1375                 1380             


Lys Leu  Gln Ser Leu Asp Leu  Ser Ala Ala Ala Glu  Met Thr Cys 
    1385                 1390                 1395             


Gly Thr  Pro Pro Gly Ala Ser  Cys Ser Glu Thr Glu  Cys Gly Gly 
    1400                 1405                 1410             


Pro Asn  Cys Arg Thr Asp Glu  Gly Glu Arg Lys Cys  Gly Gly Pro 
    1415                 1420                 1425             


Gly Cys  Gly Gly Leu Val Thr  Val Ala His Asn Ala  Trp Gln Lys 
    1430                 1435                 1440             


Ala Met  Asp Leu Asp Gln Asp  Val Leu Ser Ala Leu  Ala Glu Val 
    1445                 1450                 1455             


Glu Gln  Leu Ser Lys Met Val  Ser Glu Ala Lys Leu  Arg Ala Asp 
    1460                 1465                 1470             


Glu Ala  Lys Gln Ser Ala Glu  Asp Ile Leu Leu Lys  Thr Asn Ala 
    1475                 1480                 1485             


Thr Lys  Glu Lys Met Asp Lys  Ser Asn Glu Glu Leu  Arg Asn Leu 
    1490                 1495                 1500             


Ile Lys  Gln Ile Arg Asn Phe  Leu Thr Gln Asp Ser  Ala Asp Leu 
    1505                 1510                 1515             


Asp Ser  Ile Glu Ala Val Ala  Asn Glu Val Leu Lys  Met Glu Met 
    1520                 1525                 1530             


Pro Ser  Thr Pro Gln Gln Leu  Gln Asn Leu Thr Glu  Asp Ile Arg 
    1535                 1540                 1545             


Glu Arg  Val Glu Ser Leu Ser  Gln Val Glu Val Ile  Leu Gln His 
    1550                 1555                 1560             


Ser Ala  Ala Asp Ile Ala Arg  Ala Glu Met Leu Leu  Glu Glu Ala 
    1565                 1570                 1575             


Lys Arg  Ala Ser Lys Ser Ala  Thr Asp Val Lys Val  Thr Ala Asp 
    1580                 1585                 1590             


Met Val  Lys Glu Ala Leu Glu  Glu Ala Glu Lys Ala  Gln Val Ala 
    1595                 1600                 1605             


Ala Glu  Lys Ala Ile Lys Gln  Ala Asp Glu Asp Ile  Gln Gly Thr 
    1610                 1615                 1620             


Gln Asn  Leu Leu Thr Ser Ile  Glu Ser Glu Thr Ala  Ala Ser Glu 
    1625                 1630                 1635             


Glu Thr  Leu Phe Asn Ala Ser  Gln Arg Ile Ser Glu  Leu Glu Arg 
    1640                 1645                 1650             


Asn Val  Glu Glu Leu Lys Arg  Lys Ala Ala Gln Asn  Ser Gly Glu 
    1655                 1660                 1665             


Ala Glu  Tyr Ile Glu Lys Val  Val Tyr Thr Val Lys  Gln Ser Ala 
    1670                 1675                 1680             


Glu Asp  Val Lys Lys Thr Leu  Asp Gly Glu Leu Asp  Glu Lys Tyr 
    1685                 1690                 1695             


Lys Lys  Val Glu Asn Leu Ile  Ala Lys Lys Thr Glu  Glu Ser Ala 
    1700                 1705                 1710             


Asp Ala  Arg Arg Lys Ala Glu  Met Leu Gln Asn Glu  Ala Lys Thr 
    1715                 1720                 1725             


Leu Leu  Ala Gln Ala Asn Ser  Lys Leu Gln Leu Leu  Lys Asp Leu 
    1730                 1735                 1740             


Glu Arg  Lys Tyr Glu Asp Asn  Gln Arg Tyr Leu Glu  Asp Lys Ala 
    1745                 1750                 1755             


Gln Glu  Leu Ala Arg Leu Glu  Gly Glu Val Arg Ser  Leu Leu Lys 
    1760                 1765                 1770             


Asp Ile  Ser Gln Lys Val Ala  Val Tyr Ser Thr Cys  Leu 
    1775                 1780                 1785     


<210> 88
<211> 3122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Lys  Ile Ile Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Ser  Met Lys Ala Arg Pro  Glu Val Asn Leu Lys  Lys Tyr Ser 
    2480                 2485                 2490             


Gly Cys  Leu Lys Asp Ile Glu  Ile Ser Arg Thr Pro  Tyr Asn Ile 
    2495                 2500                 2505             


Leu Ser  Ser Pro Asp Tyr Val  Gly Val Thr Lys Gly  Cys Ser Leu 
    2510                 2515                 2520             


Glu Asn  Val Tyr Thr Val Ser  Phe Pro Lys Pro Gly  Phe Val Glu 
    2525                 2530                 2535             


Leu Ser  Pro Val Pro Ile Asp  Val Gly Thr Glu Ile  Asn Leu Ser 
    2540                 2545                 2550             


Phe Ser  Thr Lys Asn Glu Ser  Gly Ile Ile Leu Leu  Gly Ser Gly 
    2555                 2560                 2565             


Gly Thr  Pro Ala Pro Pro Arg  Arg Lys Arg Arg Gln  Thr Gly Gln 
    2570                 2575                 2580             


Ala Tyr  Tyr Ala Ile Leu Leu  Asn Arg Gly Arg Leu  Glu Val His 
    2585                 2590                 2595             


Leu Ser  Thr Gly Ala Arg Thr  Met Arg Lys Ile Val  Ile Arg Pro 
    2600                 2605                 2610             


Glu Pro  Asn Leu Phe His Asp  Gly Arg Glu His Ser  Val His Val 
    2615                 2620                 2625             


Glu Arg  Thr Arg Gly Ile Phe  Thr Val Gln Val Asp  Glu Asn Arg 
    2630                 2635                 2640             


Arg Tyr  Met Gln Asn Leu Thr  Val Glu Gln Pro Ile  Glu Val Lys 
    2645                 2650                 2655             


Lys Leu  Phe Val Gly Gly Ala  Pro Pro Glu Phe Gln  Pro Ser Pro 
    2660                 2665                 2670             


Leu Arg  Asn Ile Pro Pro Phe  Glu Gly Cys Ile Trp  Asn Leu Val 
    2675                 2680                 2685             


Ile Asn  Ser Val Pro Met Asp  Phe Ala Arg Pro Val  Ser Phe Lys 
    2690                 2695                 2700             


Asn Ala  Asp Ile Gly Arg Cys  Ala His Gln Lys Leu  Arg Glu Asp 
    2705                 2710                 2715             


Glu Asp  Gly Ala Ala Pro Ala  Glu Ile Val Ile Gln  Pro Glu Pro 
    2720                 2725                 2730             


Val Pro  Thr Pro Ala Phe Pro  Thr Pro Thr Pro Val  Leu Thr His 
    2735                 2740                 2745             


Gly Pro  Cys Ala Ala Glu Ser  Glu Pro Ala Leu Leu  Ile Gly Ser 
    2750                 2755                 2760             


Lys Gln  Phe Gly Leu Ser Arg  Asn Ser His Ile Ala  Ile Ala Phe 
    2765                 2770                 2775             


Asp Asp  Thr Lys Val Lys Asn  Arg Leu Thr Ile Glu  Leu Glu Val 
    2780                 2785                 2790             


Arg Thr  Glu Ala Glu Ser Gly  Leu Leu Phe Tyr Met  Ala Arg Ile 
    2795                 2800                 2805             


Asn His  Ala Asp Phe Ala Thr  Val Gln Leu Arg Asn  Gly Leu Pro 
    2810                 2815                 2820             


Tyr Phe  Ser Tyr Asp Leu Gly  Ser Gly Asp Thr His  Thr Met Ile 
    2825                 2830                 2835             


Pro Thr  Lys Ile Asn Asp Gly  Gln Trp His Lys Ile  Lys Ile Met 
    2840                 2845                 2850             


Arg Ser  Lys Gln Glu Gly Ile  Leu Tyr Val Asp Gly  Ala Ser Asn 
    2855                 2860                 2865             


Arg Thr  Ile Ser Pro Lys Lys  Ala Asp Ile Leu Asp  Val Val Gly 
    2870                 2875                 2880             


Met Leu  Tyr Val Gly Gly Leu  Pro Ile Asn Tyr Thr  Thr Arg Arg 
    2885                 2890                 2895             


Ile Gly  Pro Val Thr Tyr Ser  Ile Asp Gly Cys Val  Arg Asn Leu 
    2900                 2905                 2910             


His Met  Ala Glu Ala Pro Ala  Asp Leu Glu Gln Pro  Thr Ser Ser 
    2915                 2920                 2925             


Phe His  Val Gly Thr Cys Phe  Ala Asn Ala Gln Arg  Gly Thr Tyr 
    2930                 2935                 2940             


Phe Asp  Gly Thr Gly Phe Ala  Lys Ala Val Gly Gly  Phe Lys Val 
    2945                 2950                 2955             


Gly Leu  Asp Leu Leu Val Glu  Phe Glu Phe Arg Thr  Thr Thr Thr 
    2960                 2965                 2970             


Thr Gly  Val Leu Leu Gly Ile  Ser Ser Gln Lys Met  Asp Gly Met 
    2975                 2980                 2985             


Gly Ile  Glu Met Ile Asp Glu  Lys Leu Met Phe His  Val Asp Asn 
    2990                 2995                 3000             


Gly Ala  Gly Arg Phe Thr Ala  Val Tyr Asp Ala Gly  Val Pro Gly 
    3005                 3010                 3015             


His Leu  Cys Asp Gly Gln Trp  His Lys Val Thr Ala  Asn Lys Ile 
    3020                 3025                 3030             


Lys His  Arg Ile Glu Leu Thr  Val Asp Gly Asn Gln  Val Glu Ala 
    3035                 3040                 3045             


Gln Ser  Pro Asn Pro Ala Ser  Thr Ser Ala Asp Thr  Asn Asp Pro 
    3050                 3055                 3060             


Val Phe  Val Gly Gly Phe Pro  Asp Asp Leu Lys Gln  Phe Gly Leu 
    3065                 3070                 3075             


Thr Thr  Ser Ile Pro Phe Arg  Gly Cys Ile Arg Ser  Leu Lys Leu 
    3080                 3085                 3090             


Thr Lys  Gly Thr Gly Lys Pro  Leu Glu Val Asn Phe  Ala Lys Ala 
    3095                 3100                 3105             


Leu Glu  Leu Arg Gly Val Gln  Pro Val Ser Cys Pro  Ala Asn 
    3110                 3115                 3120         


<210> 89
<211> 3075
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Arg Gly Gly Val Leu Leu Val Leu Leu Leu Cys Val Ala Ala Gln 
1               5                   10                  15      


Cys Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn 
            20                  25                  30          


Ala His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met 
        35                  40                  45              


Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro 
    50                  55                  60                  


Gln Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His 
65                  70                  75                  80  


Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro 
                85                  90                  95      


Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp 
            100                 105                 110         


Leu Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn 
        115                 120                 125             


Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr 
    130                 135                 140                 


Thr Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu 
145                 150                 155                 160 


Ser Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala 
                165                 170                 175     


Asp Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu 
            180                 185                 190         


Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala 
        195                 200                 205             


Asp Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile 
    210                 215                 220                 


Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr 
225                 230                 235                 240 


Leu Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg 
                245                 250                 255     


Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys 
            260                 265                 270         


Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr Thr Lys Lys Leu 
        275                 280                 285             


Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asn Arg Cys 
    290                 295                 300                 


Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Val Ser Ser 
305                 310                 315                 320 


Gly Asn Thr Cys Glu Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys 
                325                 330                 335     


Tyr Tyr Asp Glu Ser Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala 
            340                 345                 350         


Gly Gln Phe Arg Gly Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr 
        355                 360                 365             


Met Gly Ile Asn Cys Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His 
    370                 375                 380                 


Lys Val Ser Pro Tyr Glu Asp Glu Pro Cys Arg Pro Cys Asn Cys Asp 
385                 390                 395                 400 


Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Leu His Ser 
                405                 410                 415     


Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys Pro Cys Lys Glu Gly 
            420                 425                 430         


Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu Gly Tyr Lys Asp Tyr 
        435                 440                 445             


Pro Thr Cys Val Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp 
    450                 455                 460                 


Glu Pro Cys Thr Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys 
465                 470                 475                 480 


Ala Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn 
                485                 490                 495     


Pro Arg Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Asp Val Cys 
            500                 505                 510         


Ser Ser Leu Ser Trp Pro Val Gly Gln Val Asn Ser Met Ser Gly Trp 
        515                 520                 525             


Leu Val Thr Asp Leu Ile Ser Pro Arg Lys Ile Pro Ser Gln Gln Asp 
    530                 535                 540                 


Ala Leu Gly Gly Arg His Gln Val Ser Ile Asn Asn Thr Ala Val Met 
545                 550                 555                 560 


Gln Arg Leu Ala Pro Lys Tyr Tyr Trp Ala Ala Pro Glu Ala Tyr Leu 
                565                 570                 575     


Gly Asn Lys Leu Thr Ala Phe Gly Gly Phe Leu Lys Tyr Thr Val Ser 
            580                 585                 590         


Tyr Asp Ile Pro Val Glu Thr Val Asp Ser Asn Leu Met Ser His Ala 
        595                 600                 605             


Asp Val Ile Ile Lys Gly Asn Gly Leu Thr Leu Ser Thr Gln Ala Glu 
    610                 615                 620                 


Gly Leu Ser Leu Gln Pro Tyr Glu Glu Tyr Leu Asn Val Val Arg Leu 
625                 630                 635                 640 


Val Pro Glu Asn Phe Gln Asp Phe His Ser Lys Arg Gln Ile Asp Arg 
                645                 650                 655     


Asp Gln Leu Met Thr Val Leu Ala Asn Val Thr His Leu Leu Ile Arg 
            660                 665                 670         


Ala Asn Tyr Asn Ser Ala Lys Met Ala Leu Tyr Arg Leu Glu Ser Val 
        675                 680                 685             


Ser Leu Asp Ile Ala Ser Ser Asn Ala Ile Asp Leu Val Val Ala Ala 
    690                 695                 700                 


Asp Val Glu His Cys Glu Cys Pro Gln Gly Tyr Thr Gly Thr Ser Cys 
705                 710                 715                 720 


Glu Ser Cys Leu Ser Gly Tyr Tyr Arg Val Asp Gly Ile Leu Phe Gly 
                725                 730                 735     


Gly Ile Cys Gln Pro Cys Glu Cys His Gly His Ala Ala Glu Cys Asn 
            740                 745                 750         


Val His Gly Val Cys Ile Ala Cys Ala His Asn Thr Thr Gly Val His 
        755                 760                 765             


Cys Glu Gln Cys Leu Pro Gly Phe Tyr Gly Glu Pro Ser Arg Gly Thr 
    770                 775                 780                 


Pro Gly Asp Cys Gln Pro Cys Ala Cys Pro Leu Thr Ile Ala Ser Asn 
785                 790                 795                 800 


Asn Phe Ser Pro Thr Cys His Leu Asn Asp Gly Asp Glu Val Val Cys 
                805                 810                 815     


Asp Trp Cys Ala Pro Gly Tyr Ser Gly Ala Trp Cys Glu Arg Cys Ala 
            820                 825                 830         


Asp Gly Tyr Tyr Gly Asn Pro Thr Val Pro Gly Glu Ser Cys Val Pro 
        835                 840                 845             


Cys Asp Cys Ser Gly Asn Val Asp Pro Ser Glu Ala Gly His Cys Asp 
    850                 855                 860                 


Ser Val Thr Gly Glu Cys Leu Lys Cys Leu Gly Asn Thr Asp Gly Ala 
865                 870                 875                 880 


His Cys Glu Arg Cys Ala Asp Gly Phe Tyr Gly Asp Ala Val Thr Ala 
                885                 890                 895     


Lys Asn Cys Arg Ala Cys Glu Cys His Val Lys Gly Ser His Ser Ala 
            900                 905                 910         


Val Cys His Leu Glu Thr Gly Leu Cys Asp Cys Lys Pro Asn Val Thr 
        915                 920                 925             


Gly Gln Gln Cys Asp Gln Cys Leu His Gly Tyr Tyr Gly Leu Asp Ser 
    930                 935                 940                 


Gly His Gly Cys Arg Pro Cys Asn Cys Ser Val Ala Gly Ser Val Ser 
945                 950                 955                 960 


Asp Gly Cys Thr Asp Glu Gly Gln Cys His Cys Val Pro Gly Val Ala 
                965                 970                 975     


Gly Lys Arg Cys Asp Arg Cys Ala His Gly Phe Tyr Ala Tyr Gln Asp 
            980                 985                 990         


Gly Ser Cys Thr Pro Cys Asp Cys  Pro His Thr Gln Asn  Thr Cys Asp 
        995                 1000                 1005             


Pro Glu  Thr Gly Glu Cys Val  Cys Pro Pro His Thr  Gln Gly Val 
    1010                 1015                 1020             


Lys Cys  Glu Glu Cys Glu Asp  Gly His Trp Gly Tyr  Asp Ala Glu 
    1025                 1030                 1035             


Val Gly  Cys Gln Ala Cys Asn  Cys Ser Leu Val Gly  Ser Thr His 
    1040                 1045                 1050             


His Arg  Cys Asp Val Val Thr  Gly His Cys Gln Cys  Lys Ser Lys 
    1055                 1060                 1065             


Phe Gly  Gly Arg Ala Cys Asp  Gln Cys Ser Leu Gly  Tyr Arg Asp 
    1070                 1075                 1080             


Phe Pro  Asp Cys Val Pro Cys  Asp Cys Asp Leu Arg  Gly Thr Ser 
    1085                 1090                 1095             


Gly Asp  Ala Cys Asn Leu Glu  Gln Gly Leu Cys Gly  Cys Val Glu 
    1100                 1105                 1110             


Glu Thr  Gly Ala Cys Pro Cys  Lys Glu Asn Val Phe  Gly Pro Gln 
    1115                 1120                 1125             


Cys Asn  Glu Cys Arg Glu Gly  Thr Phe Ala Leu Arg  Ala Asp Asn 
    1130                 1135                 1140             


Pro Leu  Gly Cys Ser Pro Cys  Phe Cys Ser Gly Leu  Ser His Leu 
    1145                 1150                 1155             


Cys Ser  Glu Leu Glu Asp Tyr  Val Arg Thr Pro Val  Thr Leu Gly 
    1160                 1165                 1170             


Ser Asp  Gln Pro Leu Leu Arg  Val Val Ser Gln Ser  Asn Leu Arg 
    1175                 1180                 1185             


Gly Thr  Thr Glu Gly Val Tyr  Tyr Gln Ala Pro Asp  Phe Leu Leu 
    1190                 1195                 1200             


Asp Ala  Ala Thr Val Arg Gln  His Ile Arg Ala Glu  Pro Phe Tyr 
    1205                 1210                 1215             


Trp Arg  Leu Pro Gln Gln Phe  Gln Gly Asp Gln Leu  Met Ala Tyr 
    1220                 1225                 1230             


Gly Gly  Lys Leu Lys Tyr Ser  Val Ala Phe Tyr Ser  Leu Asp Gly 
    1235                 1240                 1245             


Val Gly  Thr Ser Asn Phe Glu  Pro Gln Val Leu Ile  Lys Gly Gly 
    1250                 1255                 1260             


Arg Ile  Arg Lys Gln Val Ile  Tyr Met Asp Ala Pro  Ala Pro Glu 
    1265                 1270                 1275             


Asn Gly  Val Arg Gln Glu Gln  Glu Val Ala Met Arg  Glu Asn Phe 
    1280                 1285                 1290             


Trp Lys  Tyr Phe Asn Ser Val  Ser Glu Lys Pro Val  Thr Arg Glu 
    1295                 1300                 1305             


Asp Phe  Met Ser Val Leu Ser  Asp Ile Glu Tyr Ile  Leu Ile Lys 
    1310                 1315                 1320             


Ala Ser  Tyr Gly Gln Gly Leu  Gln Gln Ser Arg Ile  Ser Asp Ile 
    1325                 1330                 1335             


Ser Met  Glu Val Gly Arg Lys  Ala Glu Lys Leu His  Pro Glu Glu 
    1340                 1345                 1350             


Glu Val  Ala Ser Leu Leu Glu  Asn Cys Val Cys Pro  Pro Gly Thr 
    1355                 1360                 1365             


Val Gly  Phe Ser Cys Gln Asp  Cys Ala Pro Gly Tyr  His Arg Gly 
    1370                 1375                 1380             


Lys Leu  Pro Ala Gly Ser Asp  Arg Gly Pro Arg Pro  Leu Val Ala 
    1385                 1390                 1395             


Pro Cys  Val Pro Cys Ser Cys  Asn Asn His Ser Asp  Thr Cys Asp 
    1400                 1405                 1410             


Pro Asn  Thr Gly Lys Cys Leu  Asn Cys Gly Asp Asn  Thr Ala Gly 
    1415                 1420                 1425             


Asp His  Cys Asp Val Cys Thr  Ser Gly Tyr Tyr Gly  Lys Val Thr 
    1430                 1435                 1440             


Gly Ser  Ala Ser Asp Cys Ala  Leu Cys Ala Cys Pro  His Ser Pro 
    1445                 1450                 1455             


Pro Ala  Ser Phe Ser Pro Thr  Cys Val Leu Glu Gly  Asp His Asp 
    1460                 1465                 1470             


Phe Arg  Cys Asp Ala Cys Leu  Leu Gly Tyr Glu Gly  Lys His Cys 
    1475                 1480                 1485             


Glu Arg  Cys Ser Ser Ser Tyr  Tyr Gly Asn Pro Gln  Thr Pro Gly 
    1490                 1495                 1500             


Gly Ser  Cys Gln Lys Cys Asp  Cys Asn Pro His Gly  Ser Val His 
    1505                 1510                 1515             


Gly Asp  Cys Asp Arg Thr Ser  Gly Gln Cys Val Cys  Arg Leu Gly 
    1520                 1525                 1530             


Ala Ser  Gly Leu Arg Cys Asp  Glu Cys Glu Pro Arg  His Ile Leu 
    1535                 1540                 1545             


Met Glu  Thr Asp Cys Val Ser  Cys Asp Asp Glu Cys  Val Gly Val 
    1550                 1555                 1560             


Leu Leu  Asn Asp Leu Asp Glu  Ile Gly Asp Ala Val  Leu Ser Leu 
    1565                 1570                 1575             


Asn Leu  Thr Gly Ile Ile Pro  Val Pro Tyr Gly Ile  Leu Ser Asn 
    1580                 1585                 1590             


Leu Glu  Asn Thr Thr Lys Tyr  Leu Gln Glu Ser Leu  Leu Lys Glu 
    1595                 1600                 1605             


Asn Met  Gln Lys Asp Leu Gly  Lys Ile Lys Leu Glu  Gly Val Ala 
    1610                 1615                 1620             


Glu Glu  Thr Asp Asn Leu Gln  Lys Lys Leu Thr Arg  Met Leu Ala 
    1625                 1630                 1635             


Ser Thr  Gln Lys Val Asn Arg  Ala Thr Glu Arg Ile  Phe Lys Glu 
    1640                 1645                 1650             


Ser Gln  Asp Leu Ala Ile Ala  Ile Glu Arg Leu Gln  Met Ser Ile 
    1655                 1660                 1665             


Thr Glu  Ile Met Glu Lys Thr  Thr Leu Asn Gln Thr  Leu Asp Glu 
    1670                 1675                 1680             


Asp Phe  Leu Leu Pro Asn Ser  Thr Leu Gln Asn Met  Gln Gln Asn 
    1685                 1690                 1695             


Gly Thr  Ser Leu Leu Glu Ile  Met Gln Ile Arg Asp  Phe Thr Gln 
    1700                 1705                 1710             


Leu His  Gln Asn Ala Thr Leu  Glu Leu Lys Ala Ala  Glu Asp Leu 
    1715                 1720                 1725             


Leu Ser  Gln Ile Gln Glu Asn  Tyr Gln Lys Pro Leu  Glu Glu Leu 
    1730                 1735                 1740             


Glu Val  Leu Lys Glu Ala Ala  Ser His Val Leu Ser  Lys His Asn 
    1745                 1750                 1755             


Asn Glu  Leu Lys Ala Ala Glu  Ala Leu Val Arg Glu  Ala Glu Ala 
    1760                 1765                 1770             


Lys Met  Gln Glu Ser Asn His  Leu Leu Leu Met Val  Asn Ala Asn 
    1775                 1780                 1785             


Leu Arg  Glu Phe Ser Asp Lys  Lys Leu His Val Gln  Glu Glu Gln 
    1790                 1795                 1800             


Asn Leu  Thr Ser Glu Leu Ile  Val Gln Gly Arg Gly  Leu Ile Asp 
    1805                 1810                 1815             


Ala Ala  Ala Ala Gln Thr Asp  Ala Val Gln Asp Ala  Leu Glu His 
    1820                 1825                 1830             


Leu Glu  Asp His Gln Asp Lys  Leu Leu Leu Trp Ser  Ala Lys Ile 
    1835                 1840                 1845             


Arg His  His Ile Asp Asp Leu  Val Met His Met Ser  Gln Arg Asn 
    1850                 1855                 1860             


Ala Val  Asp Leu Val Tyr Arg  Ala Glu Asp His Ala  Ala Glu Phe 
    1865                 1870                 1875             


Gln Arg  Leu Ala Asp Val Leu  Tyr Ser Gly Leu Glu  Asn Ile Arg 
    1880                 1885                 1890             


Asn Val  Ser Leu Asn Ala Thr  Ser Ala Ala Tyr Val  His Tyr Asn 
    1895                 1900                 1905             


Ile Gln  Ser Leu Ile Glu Glu  Ser Glu Glu Leu Ala  Arg Asp Ala 
    1910                 1915                 1920             


His Arg  Thr Val Thr Glu Thr  Ser Leu Leu Ser Glu  Ser Leu Val 
    1925                 1930                 1935             


Ser Asn  Gly Lys Ala Ala Val  Gln Arg Ser Ser Arg  Phe Leu Lys 
    1940                 1945                 1950             


Glu Gly  Asn Asn Leu Ser Arg  Lys Leu Pro Gly Ile  Ala Leu Glu 
    1955                 1960                 1965             


Leu Ser  Glu Leu Arg Asn Lys  Thr Asn Arg Phe Gln  Glu Asn Ala 
    1970                 1975                 1980             


Val Glu  Ile Thr Arg Gln Thr  Asn Glu Ser Leu Leu  Ile Leu Arg 
    1985                 1990                 1995             


Ala Ile  Pro Lys Gly Ile Arg  Asp Lys Gly Ala Lys  Thr Lys Glu 
    2000                 2005                 2010             


Leu Ala  Thr Ser Ala Ser Gln  Ser Ala Val Ser Thr  Leu Arg Asp 
    2015                 2020                 2025             


Val Ala  Gly Leu Ser Gln Glu  Leu Leu Asn Thr Ser  Ala Ser Leu 
    2030                 2035                 2040             


Ser Arg  Val Asn Thr Thr Leu  Arg Glu Thr His Gln  Leu Leu Gln 
    2045                 2050                 2055             


Asp Ser  Thr Met Ala Thr Leu  Leu Ala Gly Arg Lys  Val Lys Asp 
    2060                 2065                 2070             


Val Glu  Ile Gln Ala Asn Leu  Leu Phe Asp Arg Leu  Lys Pro Leu 
    2075                 2080                 2085             


Lys Met  Leu Glu Glu Asn Leu  Ser Arg Asn Leu Ser  Glu Ile Lys 
    2090                 2095                 2100             


Leu Leu  Ile Ser Gln Ala Arg  Lys Gln Ala Ala Ser  Ile Lys Val 
    2105                 2110                 2115             


Ala Val  Ser Ala Asp Arg Asp  Cys Ile Arg Ala Tyr  Gln Pro Gln 
    2120                 2125                 2130             


Ile Ser  Ser Thr Asn Tyr Asn  Thr Leu Thr Leu Asn  Val Lys Thr 
    2135                 2140                 2145             


Gln Glu  Pro Asp Asn Leu Leu  Phe Tyr Leu Gly Ser  Ser Thr Ala 
    2150                 2155                 2160             


Ser Asp  Phe Leu Ala Val Glu  Met Arg Arg Gly Arg  Val Ala Phe 
    2165                 2170                 2175             


Leu Trp  Asp Leu Gly Ser Gly  Ser Thr Arg Leu Glu  Phe Pro Asp 
    2180                 2185                 2190             


Phe Pro  Ile Asp Asp Asn Arg  Trp His Ser Ile His  Val Ala Arg 
    2195                 2200                 2205             


Phe Gly  Asn Ile Gly Ser Leu  Ser Val Lys Glu Met  Ser Ser Asn 
    2210                 2215                 2220             


Gln Lys  Ser Pro Thr Lys Thr  Ser Lys Ser Pro Gly  Thr Ala Asn 
    2225                 2230                 2235             


Val Leu  Asp Val Asn Asn Ser  Thr Leu Met Phe Val  Gly Gly Leu 
    2240                 2245                 2250             


Gly Gly  Gln Ile Lys Lys Ser  Pro Ala Val Lys Val  Thr His Phe 
    2255                 2260                 2265             


Lys Gly  Cys Leu Gly Glu Ala  Phe Leu Asn Gly Lys  Ser Ile Gly 
    2270                 2275                 2280             


Leu Trp  Asn Tyr Ile Glu Arg  Glu Gly Lys Cys Arg  Gly Cys Phe 
    2285                 2290                 2295             


Gly Ser  Ser Gln Asn Glu Asp  Pro Ser Phe His Phe  Asp Gly Ser 
    2300                 2305                 2310             


Gly Tyr  Ser Val Val Glu Lys  Ser Leu Pro Ala Thr  Val Thr Gln 
    2315                 2320                 2325             


Ile Ile  Met Leu Phe Asn Thr  Phe Ser Pro Asn Gly  Leu Leu Leu 
    2330                 2335                 2340             


Tyr Leu  Gly Ser Tyr Gly Thr  Lys Asp Phe Leu Ser  Ile Glu Leu 
    2345                 2350                 2355             


Phe Arg  Gly Arg Val Lys Val  Met Thr Asp Leu Gly  Ser Gly Pro 
    2360                 2365                 2370             


Ile Thr  Leu Leu Thr Asp Arg  Arg Tyr Asn Asn Gly  Thr Trp Tyr 
    2375                 2380                 2385             


Lys Ile  Ala Phe Gln Arg Asn  Arg Lys Gln Gly Val  Leu Ala Val 
    2390                 2395                 2400             


Ile Asp  Ala Tyr Asn Thr Ser  Asn Lys Glu Thr Lys  Gln Gly Glu 
    2405                 2410                 2415             


Thr Pro  Gly Ala Ser Ser Asp  Leu Asn Arg Leu Asp  Lys Asp Pro 
    2420                 2425                 2430             


Ile Tyr  Val Gly Gly Leu Pro  Arg Ser Arg Val Val  Arg Arg Gly 
    2435                 2440                 2445             


Val Thr  Thr Lys Ser Phe Val  Gly Cys Ile Lys Asn  Leu Glu Ile 
    2450                 2455                 2460             


Ser Arg  Ser Thr Phe Asp Leu  Leu Arg Asn Ser Tyr  Gly Val Arg 
    2465                 2470                 2475             


Lys Gly  Cys Leu Leu Glu Pro  Ile Arg Ser Val Ser  Phe Leu Lys 
    2480                 2485                 2490             


Gly Gly  Tyr Ile Glu Leu Pro  Pro Lys Ser Leu Ser  Pro Glu Ser 
    2495                 2500                 2505             


Glu Trp  Leu Val Thr Phe Ala  Thr Thr Asn Ser Ser  Gly Ile Ile 
    2510                 2515                 2520             


Leu Ala  Ala Leu Gly Gly Asp  Val Glu Lys Arg Gly  Asp Arg Glu 
    2525                 2530                 2535             


Glu Ala  His Val Pro Phe Phe  Ser Val Met Leu Ile  Gly Gly Asn 
    2540                 2545                 2550             


Ile Glu  Val His Val Asn Pro  Gly Asp Gly Thr Gly  Leu Arg Lys 
    2555                 2560                 2565             


Ala Leu  Leu His Ala Pro Thr  Gly Thr Cys Ser Asp  Gly Gln Ala 
    2570                 2575                 2580             


His Ser  Ile Ser Leu Val Arg  Asn Arg Arg Ile Ile  Thr Val Gln 
    2585                 2590                 2595             


Leu Asp  Glu Asn Asn Pro Val  Glu Met Lys Leu Gly  Thr Leu Val 
    2600                 2605                 2610             


Glu Ser  Arg Thr Ile Asn Val  Ser Asn Leu Tyr Val  Gly Gly Ile 
    2615                 2620                 2625             


Pro Glu  Gly Glu Gly Thr Ser  Leu Leu Thr Met Arg  Arg Ser Phe 
    2630                 2635                 2640             


His Gly  Cys Ile Lys Asn Leu  Ile Phe Asn Leu Glu  Leu Leu Asp 
    2645                 2650                 2655             


Phe Asn  Ser Ala Val Gly His  Glu Gln Val Asp Leu  Asp Thr Cys 
    2660                 2665                 2670             


Trp Leu  Ser Glu Arg Pro Lys  Leu Ala Pro Asp Ala  Glu Asp Ser 
    2675                 2680                 2685             


Lys Leu  Leu Pro Glu Pro Arg  Ala Phe Pro Glu Gln  Cys Val Val 
    2690                 2695                 2700             


Asp Ala  Ala Leu Glu Tyr Val  Pro Gly Ala His Gln  Phe Gly Leu 
    2705                 2710                 2715             


Thr Gln  Asn Ser His Phe Ile  Leu Pro Phe Asn Gln  Ser Ala Val 
    2720                 2725                 2730             


Arg Lys  Lys Leu Ser Val Glu  Leu Ser Ile Arg Thr  Phe Ala Ser 
    2735                 2740                 2745             


Ser Gly  Leu Ile Tyr Tyr Met  Ala His Gln Asn Gln  Ala Asp Tyr 
    2750                 2755                 2760             


Ala Val  Leu Gln Leu His Gly  Gly Arg Leu His Phe  Met Phe Asp 
    2765                 2770                 2775             


Leu Gly  Lys Gly Arg Thr Lys  Val Ser His Pro Ala  Leu Leu Ser 
    2780                 2785                 2790             


Asp Gly  Lys Trp His Thr Val  Lys Thr Asp Tyr Val  Lys Arg Lys 
    2795                 2800                 2805             


Gly Phe  Ile Thr Val Asp Gly  Arg Glu Ser Pro Met  Val Thr Val 
    2810                 2815                 2820             


Val Gly  Asp Gly Thr Met Leu  Asp Val Glu Gly Leu  Phe Tyr Leu 
    2825                 2830                 2835             


Gly Gly  Leu Pro Ser Gln Tyr  Gln Ala Arg Lys Ile  Gly Asn Ile 
    2840                 2845                 2850             


Thr His  Ser Ile Pro Ala Cys  Ile Gly Asp Val Thr  Val Asn Ser 
    2855                 2860                 2865             


Lys Gln  Leu Asp Lys Asp Ser  Pro Val Ser Ala Phe  Thr Val Asn 
    2870                 2875                 2880             


Arg Cys  Tyr Ala Val Ala Gln  Glu Gly Thr Tyr Phe  Asp Gly Ser 
    2885                 2890                 2895             


Gly Tyr  Ala Ala Leu Val Lys  Glu Gly Tyr Lys Val  Gln Ser Asp 
    2900                 2905                 2910             


Val Asn  Ile Thr Leu Glu Phe  Arg Thr Ser Ser Gln  Asn Gly Val 
    2915                 2920                 2925             


Leu Leu  Gly Ile Ser Thr Ala  Lys Val Asp Ala Ile  Gly Leu Glu 
    2930                 2935                 2940             


Leu Val  Asp Gly Lys Val Leu  Phe His Val Asn Asn  Gly Ala Gly 
    2945                 2950                 2955             


Arg Ile  Thr Ala Ala Tyr Glu  Pro Lys Thr Ala Thr  Val Leu Cys 
    2960                 2965                 2970             


Asp Gly  Lys Trp His Thr Leu  Gln Ala Asn Lys Ser  Lys His Arg 
    2975                 2980                 2985             


Ile Thr  Leu Ile Val Asp Gly  Asn Ala Val Gly Ala  Glu Ser Pro 
    2990                 2995                 3000             


His Thr  Gln Ser Thr Ser Val  Asp Thr Asn Asn Pro  Ile Tyr Val 
    3005                 3010                 3015             


Gly Gly  Tyr Pro Ala Gly Val  Lys Gln Lys Cys Leu  Arg Ser Gln 
    3020                 3025                 3030             


Thr Ser  Phe Arg Gly Cys Leu  Arg Lys Leu Ala Leu  Ile Lys Ser 
    3035                 3040                 3045             


Pro Gln  Val Gln Ser Phe Asp  Phe Ser Arg Ala Phe  Glu Leu His 
    3050                 3055                 3060             


Gly Val  Phe Leu His Ser Cys  Pro Gly Thr Glu Ser  
    3065                 3070                 3075 


<210> 90
<211> 3695
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Ala Lys Arg Leu Cys Ala Gly Ser Ala Leu Cys Val Arg Gly Pro 
1               5                   10                  15      


Arg Gly Pro Ala Pro Leu Leu Leu Val Gly Leu Ala Leu Leu Gly Ala 
            20                  25                  30          


Ala Arg Ala Arg Glu Glu Ala Gly Gly Gly Phe Ser Leu His Pro Pro 
        35                  40                  45              


Tyr Phe Asn Leu Ala Glu Gly Ala Arg Ile Ala Ala Ser Ala Thr Cys 
    50                  55                  60                  


Gly Glu Glu Ala Pro Ala Arg Gly Ser Pro Arg Pro Thr Glu Asp Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Val Ala Gly Gly Asp Pro Asn Gln 
                85                  90                  95      


Thr Ile Arg Gly Gln Tyr Cys Asp Ile Cys Thr Ala Ala Asn Ser Asn 
            100                 105                 110         


Lys Ala His Pro Ala Ser Asn Ala Ile Asp Gly Thr Glu Arg Trp Trp 
        115                 120                 125             


Gln Ser Pro Pro Leu Ser Arg Gly Leu Glu Tyr Asn Glu Val Asn Val 
    130                 135                 140                 


Thr Leu Asp Leu Gly Gln Val Phe His Val Ala Tyr Val Leu Ile Lys 
145                 150                 155                 160 


Phe Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Met 
                165                 170                 175     


Asp Phe Gly Arg Thr Tyr Gln Pro Trp Gln Phe Phe Ala Ser Ser Lys 
            180                 185                 190         


Arg Asp Cys Leu Glu Arg Phe Gly Pro Gln Thr Leu Glu Arg Ile Thr 
        195                 200                 205             


Arg Asp Asp Ala Ala Ile Cys Thr Thr Glu Tyr Ser Arg Ile Val Pro 
    210                 215                 220                 


Leu Glu Asn Gly Glu Ile Val Val Ser Leu Val Asn Gly Arg Pro Gly 
225                 230                 235                 240 


Ala Met Asn Phe Ser Tyr Ser Pro Leu Leu Arg Glu Phe Thr Lys Ala 
                245                 250                 255     


Thr Asn Val Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His 
            260                 265                 270         


Leu Met Gly Lys Ala Leu Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr 
        275                 280                 285             


Tyr Ser Ile Lys Asp Ile Ser Ile Gly Gly Arg Cys Val Cys His Gly 
    290                 295                 300                 


His Ala Asp Ala Cys Asp Ala Lys Asp Pro Thr Asp Pro Phe Arg Leu 
305                 310                 315                 320 


Gln Cys Thr Cys Gln His Asn Thr Cys Gly Gly Thr Cys Asp Arg Cys 
                325                 330                 335     


Cys Pro Gly Phe Asn Gln Gln Pro Trp Lys Pro Ala Thr Ala Asn Ser 
            340                 345                 350         


Ala Asn Glu Cys Gln Ser Cys Asn Cys Tyr Gly His Ala Thr Asp Cys 
        355                 360                 365             


Tyr Tyr Asp Pro Glu Val Asp Arg Arg Arg Ala Ser Gln Ser Leu Asp 
    370                 375                 380                 


Gly Thr Tyr Gln Gly Gly Gly Val Cys Ile Asp Cys Gln His His Thr 
385                 390                 395                 400 


Thr Gly Val Asn Cys Glu Arg Cys Leu Pro Gly Phe Tyr Arg Ser Pro 
                405                 410                 415     


Asn His Pro Leu Asp Ser Pro His Val Cys Arg Arg Cys Asn Cys Glu 
            420                 425                 430         


Ser Asp Phe Thr Asp Gly Thr Cys Glu Asp Leu Thr Gly Arg Cys Tyr 
        435                 440                 445             


Cys Arg Pro Asn Phe Ser Gly Glu Arg Cys Asp Val Cys Ala Glu Gly 
    450                 455                 460                 


Phe Thr Gly Phe Pro Ser Cys Tyr Pro Thr Pro Ser Ser Ser Asn Asp 
465                 470                 475                 480 


Thr Arg Glu Gln Val Leu Pro Ala Gly Gln Ile Val Asn Cys Asp Cys 
                485                 490                 495     


Ser Ala Ala Gly Thr Gln Gly Asn Ala Cys Arg Lys Asp Pro Arg Val 
            500                 505                 510         


Gly Arg Cys Leu Cys Lys Pro Asn Phe Gln Gly Thr His Cys Glu Leu 
        515                 520                 525             


Cys Ala Pro Gly Phe Tyr Gly Pro Gly Cys Gln Pro Cys Gln Cys Ser 
    530                 535                 540                 


Ser Pro Gly Val Ala Asp Asp Arg Cys Asp Pro Asp Thr Gly Gln Cys 
545                 550                 555                 560 


Arg Cys Arg Val Gly Phe Glu Gly Ala Thr Cys Asp Arg Cys Ala Pro 
                565                 570                 575     


Gly Tyr Phe His Phe Pro Leu Cys Gln Leu Cys Gly Cys Ser Pro Ala 
            580                 585                 590         


Gly Thr Leu Pro Glu Gly Cys Asp Glu Ala Gly Arg Cys Leu Cys Gln 
        595                 600                 605             


Pro Glu Phe Ala Gly Pro His Cys Asp Arg Cys Arg Pro Gly Tyr His 
    610                 615                 620                 


Gly Phe Pro Asn Cys Gln Ala Cys Thr Cys Asp Pro Arg Gly Ala Leu 
625                 630                 635                 640 


Asp Gln Leu Cys Gly Ala Gly Gly Leu Cys Arg Cys Arg Pro Gly Tyr 
                645                 650                 655     


Thr Gly Thr Ala Cys Gln Glu Cys Ser Pro Gly Phe His Gly Phe Pro 
            660                 665                 670         


Ser Cys Val Pro Cys His Cys Ser Ala Glu Gly Ser Leu His Ala Ala 
        675                 680                 685             


Cys Asp Pro Arg Ser Gly Gln Cys Ser Cys Arg Pro Arg Val Thr Gly 
    690                 695                 700                 


Leu Arg Cys Asp Thr Cys Val Pro Gly Ala Tyr Asn Phe Pro Tyr Cys 
705                 710                 715                 720 


Glu Ala Gly Ser Cys His Pro Ala Gly Leu Ala Pro Val Asp Pro Ala 
                725                 730                 735     


Leu Pro Glu Ala Gln Val Pro Cys Met Cys Arg Ala His Val Glu Gly 
            740                 745                 750         


Pro Ser Cys Asp Arg Cys Lys Pro Gly Phe Trp Gly Leu Ser Pro Ser 
        755                 760                 765             


Asn Pro Glu Gly Cys Thr Arg Cys Ser Cys Asp Leu Arg Gly Thr Leu 
    770                 775                 780                 


Gly Gly Val Ala Glu Cys Gln Pro Gly Thr Gly Gln Cys Phe Cys Lys 
785                 790                 795                 800 


Pro His Val Cys Gly Gln Ala Cys Ala Ser Cys Lys Asp Gly Phe Phe 
                805                 810                 815     


Gly Leu Asp Gln Ala Asp Tyr Phe Gly Cys Arg Ser Cys Arg Cys Asp 
            820                 825                 830         


Ile Gly Gly Ala Leu Gly Gln Ser Cys Glu Pro Arg Thr Gly Val Cys 
        835                 840                 845             


Arg Cys Arg Pro Asn Thr Gln Gly Pro Thr Cys Ser Glu Pro Ala Arg 
    850                 855                 860                 


Asp His Tyr Leu Pro Asp Leu His His Leu Arg Leu Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Ala Thr Pro Glu Gly His Ala Val Arg Phe Gly Phe Asn Pro Leu 
                885                 890                 895     


Glu Phe Glu Asn Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Pro Val 
            900                 905                 910         


Gln Pro Arg Ile Val Ala Arg Leu Asn Leu Thr Ser Pro Asp Leu Phe 
        915                 920                 925             


Trp Leu Val Phe Arg Tyr Val Asn Arg Gly Ala Met Ser Val Ser Gly 
    930                 935                 940                 


Arg Val Ser Val Arg Glu Glu Gly Arg Ser Ala Thr Cys Ala Asn Cys 
945                 950                 955                 960 


Thr Ala Gln Ser Gln Pro Val Ala Phe Pro Pro Ser Thr Glu Pro Ala 
                965                 970                 975     


Phe Ile Thr Val Pro Gln Arg Gly Phe Gly Glu Pro Phe Val Leu Asn 
            980                 985                 990         


Pro Gly Thr Trp Ala Leu Arg Val  Glu Ala Glu Gly Val  Leu Leu Asp 
        995                 1000                 1005             


Tyr Val  Val Leu Leu Pro Ser  Ala Tyr Tyr Glu Ala  Ala Leu Leu 
    1010                 1015                 1020             


Gln Leu  Arg Val Thr Glu Ala  Cys Thr Tyr Arg Pro  Ser Ala Gln 
    1025                 1030                 1035             


Gln Ser  Gly Asp Asn Cys Leu  Leu Tyr Thr His Leu  Pro Leu Asp 
    1040                 1045                 1050             


Gly Phe  Pro Ser Ala Ala Gly  Leu Glu Ala Leu Cys  Arg Gln Asp 
    1055                 1060                 1065             


Asn Ser  Leu Pro Arg Pro Cys  Pro Thr Glu Gln Leu  Ser Pro Ser 
    1070                 1075                 1080             


His Pro  Pro Leu Ile Thr Cys  Thr Gly Ser Asp Val  Asp Val Gln 
    1085                 1090                 1095             


Leu Gln  Val Ala Val Pro Gln  Pro Gly Arg Tyr Ala  Leu Val Val 
    1100                 1105                 1110             


Glu Tyr  Ala Asn Glu Asp Ala  Arg Gln Glu Val Gly  Val Ala Val 
    1115                 1120                 1125             


His Thr  Pro Gln Arg Ala Pro  Gln Gln Gly Leu Leu  Ser Leu His 
    1130                 1135                 1140             


Pro Cys  Leu Tyr Ser Thr Leu  Cys Arg Gly Thr Ala  Arg Asp Thr 
    1145                 1150                 1155             


Gln Asp  His Leu Ala Val Phe  His Leu Asp Ser Glu  Ala Ser Val 
    1160                 1165                 1170             


Arg Leu  Thr Ala Glu Gln Ala  Arg Phe Phe Leu His  Gly Val Thr 
    1175                 1180                 1185             


Leu Val  Pro Ile Glu Glu Phe  Ser Pro Glu Phe Val  Glu Pro Arg 
    1190                 1195                 1200             


Val Ser  Cys Ile Ser Ser His  Gly Ala Phe Gly Pro  Asn Ser Ala 
    1205                 1210                 1215             


Ala Cys  Leu Pro Ser Arg Phe  Pro Lys Pro Pro Gln  Pro Ile Ile 
    1220                 1225                 1230             


Leu Arg  Asp Cys Gln Val Ile  Pro Leu Pro Pro Gly  Leu Pro Leu 
    1235                 1240                 1245             


Thr His  Ala Gln Asp Leu Thr  Pro Ala Met Ser Pro  Ala Gly Pro 
    1250                 1255                 1260             


Arg Pro  Arg Pro Pro Thr Ala  Val Asp Pro Asp Ala  Glu Pro Thr 
    1265                 1270                 1275             


Leu Leu  Arg Glu Pro Gln Ala  Thr Val Val Phe Thr  Thr His Val 
    1280                 1285                 1290             


Pro Thr  Leu Gly Arg Tyr Ala  Phe Leu Leu His Gly  Tyr Gln Pro 
    1295                 1300                 1305             


Ala His  Pro Thr Phe Pro Val  Glu Val Leu Ile Asn  Ala Gly Arg 
    1310                 1315                 1320             


Val Trp  Gln Gly His Ala Asn  Ala Ser Phe Cys Pro  His Gly Tyr 
    1325                 1330                 1335             


Gly Cys  Arg Thr Leu Val Val  Cys Glu Gly Gln Ala  Leu Leu Asp 
    1340                 1345                 1350             


Val Thr  His Ser Glu Leu Thr  Val Thr Val Arg Val  Pro Lys Gly 
    1355                 1360                 1365             


Arg Trp  Leu Trp Leu Asp Tyr  Val Leu Val Val Pro  Glu Asn Val 
    1370                 1375                 1380             


Tyr Ser  Phe Gly Tyr Leu Arg  Glu Glu Pro Leu Asp  Lys Ser Tyr 
    1385                 1390                 1395             


Asp Phe  Ile Ser His Cys Ala  Ala Gln Gly Tyr His  Ile Ser Pro 
    1400                 1405                 1410             


Ser Ser  Ser Ser Leu Phe Cys  Arg Asn Ala Ala Ala  Ser Leu Ser 
    1415                 1420                 1425             


Leu Phe  Tyr Asn Asn Gly Ala  Arg Pro Cys Gly Cys  His Glu Val 
    1430                 1435                 1440             


Gly Ala  Thr Gly Pro Thr Cys  Glu Pro Phe Gly Gly  Gln Cys Pro 
    1445                 1450                 1455             


Cys His  Ala His Val Ile Gly  Arg Asp Cys Ser Arg  Cys Ala Thr 
    1460                 1465                 1470             


Gly Tyr  Trp Gly Phe Pro Asn  Cys Arg Pro Cys Asp  Cys Gly Ala 
    1475                 1480                 1485             


Arg Leu  Cys Asp Glu Leu Thr  Gly Gln Cys Ile Cys  Pro Pro Arg 
    1490                 1495                 1500             


Thr Ile  Pro Pro Asp Cys Leu  Leu Cys Gln Pro Gln  Thr Phe Gly 
    1505                 1510                 1515             


Cys His  Pro Leu Val Gly Cys  Glu Glu Cys Asn Cys  Ser Gly Pro 
    1520                 1525                 1530             


Gly Ile  Gln Glu Leu Thr Asp  Pro Thr Cys Asp Thr  Asp Ser Gly 
    1535                 1540                 1545             


Gln Cys  Lys Cys Arg Pro Asn  Val Thr Gly Arg Arg  Cys Asp Thr 
    1550                 1555                 1560             


Cys Ser  Pro Gly Phe His Gly  Tyr Pro Arg Cys Arg  Pro Cys Asp 
    1565                 1570                 1575             


Cys His  Glu Ala Gly Thr Ala  Pro Gly Val Cys Asp  Pro Leu Thr 
    1580                 1585                 1590             


Gly Gln  Cys Tyr Cys Lys Glu  Asn Val Gln Gly Pro  Lys Cys Asp 
    1595                 1600                 1605             


Gln Cys  Ser Leu Gly Thr Phe  Ser Leu Asp Ala Ala  Asn Pro Lys 
    1610                 1615                 1620             


Gly Cys  Thr Arg Cys Phe Cys  Phe Gly Ala Thr Glu  Arg Cys Arg 
    1625                 1630                 1635             


Ser Ser  Ser Tyr Thr Arg Gln  Glu Phe Val Asp Met  Glu Gly Trp 
    1640                 1645                 1650             


Val Leu  Leu Ser Thr Asp Arg  Gln Val Val Pro His  Glu Arg Gln 
    1655                 1660                 1665             


Pro Gly  Thr Glu Met Leu Arg  Ala Asp Leu Arg His  Val Pro Glu 
    1670                 1675                 1680             


Ala Val  Pro Glu Ala Phe Pro  Glu Leu Tyr Trp Gln  Ala Pro Pro 
    1685                 1690                 1695             


Ser Tyr  Leu Gly Asp Arg Val  Ser Ser Tyr Gly Gly  Thr Leu Arg 
    1700                 1705                 1710             


Tyr Glu  Leu His Ser Glu Thr  Gln Arg Gly Asp Val  Phe Val Pro 
    1715                 1720                 1725             


Met Glu  Ser Arg Pro Asp Val  Val Leu Gln Gly Asn  Gln Met Ser 
    1730                 1735                 1740             


Ile Thr  Phe Leu Glu Pro Ala  Tyr Pro Thr Pro Gly  His Val His 
    1745                 1750                 1755             


Arg Gly  Gln Leu Gln Leu Val  Glu Gly Asn Phe Arg  His Thr Glu 
    1760                 1765                 1770             


Thr Arg  Asn Thr Val Ser Arg  Glu Glu Leu Met Met  Val Leu Ala 
    1775                 1780                 1785             


Ser Leu  Glu Gln Leu Gln Ile  Arg Ala Leu Phe Ser  Gln Ile Ser 
    1790                 1795                 1800             


Ser Ala  Val Phe Leu Arg Arg  Val Ala Leu Glu Val  Ala Ser Pro 
    1805                 1810                 1815             


Ala Gly  Gln Gly Ala Leu Ala  Ser Asn Val Glu Leu  Cys Leu Cys 
    1820                 1825                 1830             


Pro Ala  Ser Tyr Arg Gly Asp  Ser Cys Gln Glu Cys  Ala Pro Gly 
    1835                 1840                 1845             


Phe Tyr  Arg Asp Val Lys Gly  Leu Phe Leu Gly Arg  Cys Val Pro 
    1850                 1855                 1860             


Cys Gln  Cys His Gly His Ser  Asp Arg Cys Leu Pro  Gly Ser Gly 
    1865                 1870                 1875             


Val Cys  Val Asp Cys Gln His  Asn Thr Glu Gly Ala  His Cys Glu 
    1880                 1885                 1890             


Arg Cys  Gln Ala Gly Phe Val  Ser Ser Arg Asp Asp  Pro Ser Ala 
    1895                 1900                 1905             


Pro Cys  Val Ser Cys Pro Cys  Pro Leu Ser Val Pro  Ser Asn Asn 
    1910                 1915                 1920             


Phe Ala  Glu Gly Cys Val Leu  Arg Gly Gly Arg Thr  Gln Cys Leu 
    1925                 1930                 1935             


Cys Lys  Pro Gly Tyr Ala Gly  Ala Ser Cys Glu Arg  Cys Ala Pro 
    1940                 1945                 1950             


Gly Phe  Phe Gly Asn Pro Leu  Val Leu Gly Ser Ser  Cys Gln Pro 
    1955                 1960                 1965             


Cys Asp  Cys Ser Gly Asn Gly  Asp Pro Asn Leu Leu  Phe Ser Asp 
    1970                 1975                 1980             


Cys Asp  Pro Leu Thr Gly Ala  Cys Arg Gly Cys Leu  Arg His Thr 
    1985                 1990                 1995             


Thr Gly  Pro Arg Cys Glu Ile  Cys Ala Pro Gly Phe  Tyr Gly Asn 
    2000                 2005                 2010             


Ala Leu  Leu Pro Gly Asn Cys  Thr Arg Cys Asp Cys  Thr Pro Cys 
    2015                 2020                 2025             


Gly Thr  Glu Ala Cys Asp Pro  His Ser Gly His Cys  Leu Cys Lys 
    2030                 2035                 2040             


Ala Gly  Val Thr Gly Arg Arg  Cys Asp Arg Cys Gln  Glu Gly His 
    2045                 2050                 2055             


Phe Gly  Phe Asp Gly Cys Gly  Gly Cys Arg Pro Cys  Ala Cys Gly 
    2060                 2065                 2070             


Pro Ala  Ala Glu Gly Ser Glu  Cys His Pro Gln Ser  Gly Gln Cys 
    2075                 2080                 2085             


His Cys  Arg Pro Gly Thr Met  Gly Pro Gln Cys Arg  Glu Cys Ala 
    2090                 2095                 2100             


Pro Gly  Tyr Trp Gly Leu Pro  Glu Gln Gly Cys Arg  Arg Cys Gln 
    2105                 2110                 2115             


Cys Pro  Gly Gly Arg Cys Asp  Pro His Thr Gly Arg  Cys Asn Cys 
    2120                 2125                 2130             


Pro Pro  Gly Leu Ser Gly Glu  Arg Cys Asp Thr Cys  Ser Gln Gln 
    2135                 2140                 2145             


His Gln  Val Pro Val Pro Gly  Gly Pro Val Gly His  Ser Ile His 
    2150                 2155                 2160             


Cys Glu  Val Cys Asp His Cys  Val Val Leu Leu Leu  Asp Asp Leu 
    2165                 2170                 2175             


Glu Arg  Ala Gly Ala Leu Leu  Pro Ala Ile His Glu  Gln Leu Arg 
    2180                 2185                 2190             


Gly Ile  Asn Ala Ser Ser Met  Ala Trp Ala Arg Leu  His Arg Leu 
    2195                 2200                 2205             


Asn Ala  Ser Ile Ala Asp Leu  Gln Ser Gln Leu Arg  Ser Pro Leu 
    2210                 2215                 2220             


Gly Pro  Arg His Glu Thr Ala  Gln Gln Leu Glu Val  Leu Glu Gln 
    2225                 2230                 2235             


Gln Ser  Thr Ser Leu Gly Gln  Asp Ala Arg Arg Leu  Gly Gly Gln 
    2240                 2245                 2250             


Ala Val  Gly Thr Arg Asp Gln  Ala Ser Gln Leu Leu  Ala Gly Thr 
    2255                 2260                 2265             


Glu Ala  Thr Leu Gly His Ala  Lys Thr Leu Leu Ala  Ala Ile Arg 
    2270                 2275                 2280             


Ala Val  Asp Arg Thr Leu Ser  Glu Leu Met Ser Gln  Thr Gly His 
    2285                 2290                 2295             


Leu Gly  Leu Ala Asn Ala Ser  Ala Pro Ser Gly Glu  Gln Leu Leu 
    2300                 2305                 2310             


Arg Thr  Leu Ala Glu Val Glu  Arg Leu Leu Trp Glu  Met Arg Ala 
    2315                 2320                 2325             


Arg Asp  Leu Gly Ala Pro Gln  Ala Ala Ala Glu Ala  Glu Leu Ala 
    2330                 2335                 2340             


Ala Ala  Gln Arg Leu Leu Ala  Arg Val Gln Glu Gln  Leu Ser Ser 
    2345                 2350                 2355             


Leu Trp  Glu Glu Asn Gln Ala  Leu Ala Thr Gln Thr  Arg Asp Arg 
    2360                 2365                 2370             


Leu Ala  Gln His Glu Ala Gly  Leu Met Asp Leu Arg  Glu Ala Leu 
    2375                 2380                 2385             


Asn Arg  Ala Val Asp Ala Thr  Arg Glu Ala Gln Glu  Leu Asn Ser 
    2390                 2395                 2400             


Arg Asn  Gln Glu Arg Leu Glu  Glu Ala Leu Gln Arg  Lys Gln Glu 
    2405                 2410                 2415             


Leu Ser  Arg Asp Asn Ala Thr  Leu Gln Ala Thr Leu  His Ala Ala 
    2420                 2425                 2430             


Arg Asp  Thr Leu Ala Ser Val  Phe Arg Leu Leu His  Ser Leu Asp 
    2435                 2440                 2445             


Gln Ala  Lys Glu Glu Leu Glu  Arg Leu Ala Ala Ser  Leu Asp Gly 
    2450                 2455                 2460             


Ala Arg  Thr Pro Leu Leu Gln  Arg Met Gln Thr Phe  Ser Pro Ala 
    2465                 2470                 2475             


Gly Ser  Lys Leu Arg Leu Val  Glu Ala Ala Glu Ala  His Ala Gln 
    2480                 2485                 2490             


Gln Leu  Gly Gln Leu Ala Leu  Asn Leu Ser Ser Ile  Ile Leu Asp 
    2495                 2500                 2505             


Val Asn  Gln Asp Arg Leu Thr  Gln Arg Ala Ile Glu  Ala Ser Asn 
    2510                 2515                 2520             


Ala Tyr  Ser Arg Ile Leu Gln  Ala Val Gln Ala Ala  Glu Asp Ala 
    2525                 2530                 2535             


Ala Gly  Gln Ala Leu Gln Gln  Ala Asp His Thr Trp  Ala Thr Val 
    2540                 2545                 2550             


Val Arg  Gln Gly Leu Val Asp  Arg Ala Gln Gln Leu  Leu Ala Asn 
    2555                 2560                 2565             


Ser Thr  Ala Leu Glu Glu Ala  Met Leu Gln Glu Gln  Gln Arg Leu 
    2570                 2575                 2580             


Gly Leu  Val Trp Ala Ala Leu  Gln Gly Ala Arg Thr  Gln Leu Arg 
    2585                 2590                 2595             


Asp Val  Arg Ala Lys Lys Asp  Gln Leu Glu Ala His  Ile Gln Ala 
    2600                 2605                 2610             


Ala Gln  Ala Met Leu Ala Met  Asp Thr Asp Glu Thr  Ser Lys Lys 
    2615                 2620                 2625             


Ile Ala  His Ala Lys Ala Val  Ala Ala Glu Ala Gln  Asp Thr Ala 
    2630                 2635                 2640             


Thr Arg  Val Gln Ser Gln Leu  Gln Ala Met Gln Glu  Asn Val Glu 
    2645                 2650                 2655             


Arg Trp  Gln Gly Gln Tyr Glu  Gly Leu Arg Gly Gln  Asp Leu Gly 
    2660                 2665                 2670             


Gln Ala  Val Leu Asp Ala Gly  His Ser Val Ser Thr  Leu Glu Lys 
    2675                 2680                 2685             


Thr Leu  Pro Gln Leu Leu Ala  Lys Leu Ser Ile Leu  Glu Asn Arg 
    2690                 2695                 2700             


Gly Val  His Asn Ala Ser Leu  Ala Leu Ser Ala Ser  Ile Gly Arg 
    2705                 2710                 2715             


Val Arg  Glu Leu Ile Ala Gln  Ala Arg Gly Ala Ala  Ser Lys Val 
    2720                 2725                 2730             


Lys Val  Pro Met Lys Phe Asn  Gly Arg Ser Gly Val  Gln Leu Arg 
    2735                 2740                 2745             


Thr Pro  Arg Asp Leu Ala Asp  Leu Ala Ala Tyr Thr  Ala Leu Lys 
    2750                 2755                 2760             


Phe Tyr  Leu Gln Gly Pro Glu  Pro Glu Pro Gly Gln  Gly Thr Glu 
    2765                 2770                 2775             


Asp Arg  Phe Val Met Tyr Met  Gly Ser Arg Gln Ala  Thr Gly Asp 
    2780                 2785                 2790             


Tyr Met  Gly Val Ser Leu Arg  Asp Lys Lys Val His  Trp Val Tyr 
    2795                 2800                 2805             


Gln Leu  Gly Glu Ala Gly Pro  Ala Val Leu Ser Ile  Asp Glu Asp 
    2810                 2815                 2820             


Ile Gly  Glu Gln Phe Ala Ala  Val Ser Leu Asp Arg  Thr Leu Gln 
    2825                 2830                 2835             


Phe Gly  His Met Ser Val Thr  Val Glu Arg Gln Met  Ile Gln Glu 
    2840                 2845                 2850             


Thr Lys  Gly Asp Thr Val Ala  Pro Gly Ala Glu Gly  Leu Leu Asn 
    2855                 2860                 2865             


Leu Arg  Pro Asp Asp Phe Val  Phe Tyr Val Gly Gly  Tyr Pro Ser 
    2870                 2875                 2880             


Thr Phe  Thr Pro Pro Pro Leu  Leu Arg Phe Pro Gly  Tyr Arg Gly 
    2885                 2890                 2895             


Cys Ile  Glu Met Asp Thr Leu  Asn Glu Glu Val Val  Ser Leu Tyr 
    2900                 2905                 2910             


Asn Phe  Glu Arg Thr Phe Gln  Leu Asp Thr Ala Val  Asp Arg Pro 
    2915                 2920                 2925             


Cys Ala  Arg Ser Lys Ser Thr  Gly Asp Pro Trp Leu  Thr Asp Gly 
    2930                 2935                 2940             


Ser Tyr  Leu Asp Gly Thr Gly  Phe Ala Arg Ile Ser  Phe Asp Ser 
    2945                 2950                 2955             


Gln Ile  Ser Thr Thr Lys Arg  Phe Glu Gln Glu Leu  Arg Leu Val 
    2960                 2965                 2970             


Ser Tyr  Ser Gly Val Leu Phe  Phe Leu Lys Gln Gln  Ser Gln Phe 
    2975                 2980                 2985             


Leu Cys  Leu Ala Val Gln Glu  Gly Ser Leu Val Leu  Leu Tyr Asp 
    2990                 2995                 3000             


Phe Gly  Ala Gly Leu Lys Lys  Ala Val Pro Leu Gln  Pro Pro Pro 
    3005                 3010                 3015             


Pro Leu  Thr Ser Ala Ser Lys  Ala Ile Gln Val Phe  Leu Leu Gly 
    3020                 3025                 3030             


Gly Ser  Arg Lys Arg Val Leu  Val Arg Val Glu Arg  Ala Thr Val 
    3035                 3040                 3045             


Tyr Ser  Val Glu Gln Asp Asn  Asp Leu Glu Leu Ala  Asp Ala Tyr 
    3050                 3055                 3060             


Tyr Leu  Gly Gly Val Pro Pro  Asp Gln Leu Pro Pro  Ser Leu Arg 
    3065                 3070                 3075             


Arg Leu  Phe Pro Thr Gly Gly  Ser Val Arg Gly Cys  Val Lys Gly 
    3080                 3085                 3090             


Ile Lys  Ala Leu Gly Lys Tyr  Val Asp Leu Lys Arg  Leu Asn Thr 
    3095                 3100                 3105             


Thr Gly  Val Ser Ala Gly Cys  Thr Ala Asp Leu Leu  Val Gly Arg 
    3110                 3115                 3120             


Ala Met  Thr Phe His Gly His  Gly Phe Leu Arg Leu  Ala Leu Ser 
    3125                 3130                 3135             


Asn Val  Ala Pro Leu Thr Gly  Asn Val Tyr Ser Gly  Phe Gly Phe 
    3140                 3145                 3150             


His Ser  Ala Gln Asp Ser Ala  Leu Leu Tyr Tyr Arg  Ala Ser Pro 
    3155                 3160                 3165             


Asp Gly  Leu Cys Gln Val Ser  Leu Gln Gln Gly Arg  Val Ser Leu 
    3170                 3175                 3180             


Gln Leu  Leu Arg Thr Glu Val  Lys Thr Gln Ala Gly  Phe Ala Asp 
    3185                 3190                 3195             


Gly Ala  Pro His Tyr Val Ala  Phe Tyr Ser Asn Ala  Thr Gly Val 
    3200                 3205                 3210             


Trp Leu  Tyr Val Asp Asp Gln  Leu Gln Gln Met Lys  Pro His Arg 
    3215                 3220                 3225             


Gly Pro  Pro Pro Glu Leu Gln  Pro Gln Pro Glu Gly  Pro Pro Arg 
    3230                 3235                 3240             


Leu Leu  Leu Gly Gly Leu Pro  Glu Ser Gly Thr Ile  Tyr Asn Phe 
    3245                 3250                 3255             


Ser Gly  Cys Ile Ser Asn Val  Phe Val Gln Arg Leu  Leu Gly Pro 
    3260                 3265                 3270             


Gln Arg  Val Phe Asp Leu Gln  Gln Asn Leu Gly Ser  Val Asn Val 
    3275                 3280                 3285             


Ser Thr  Gly Cys Ala Pro Ala  Leu Gln Ala Gln Thr  Pro Gly Leu 
    3290                 3295                 3300             


Gly Pro  Arg Gly Leu Gln Ala  Thr Ala Arg Lys Ala  Ser Arg Arg 
    3305                 3310                 3315             


Ser Arg  Gln Pro Ala Arg His  Pro Ala Cys Met Leu  Pro Pro His 
    3320                 3325                 3330             


Leu Arg  Thr Thr Arg Asp Ser  Tyr Gln Phe Gly Gly  Ser Leu Ser 
    3335                 3340                 3345             


Ser His  Leu Glu Phe Val Gly  Ile Leu Ala Arg His  Arg Asn Trp 
    3350                 3355                 3360             


Pro Ser  Leu Ser Met His Val  Leu Pro Arg Ser Ser  Arg Gly Leu 
    3365                 3370                 3375             


Leu Leu  Phe Thr Ala Arg Leu  Arg Pro Gly Ser Pro  Ser Leu Ala 
    3380                 3385                 3390             


Leu Phe  Leu Ser Asn Gly His  Phe Val Ala Gln Met  Glu Gly Leu 
    3395                 3400                 3405             


Gly Thr  Arg Leu Arg Ala Gln  Ser Arg Gln Arg Ser  Arg Pro Gly 
    3410                 3415                 3420             


Arg Trp  His Lys Val Ser Val  Arg Trp Glu Lys Asn  Arg Ile Leu 
    3425                 3430                 3435             


Leu Val  Thr Asp Gly Ala Arg  Ala Trp Ser Gln Glu  Gly Pro His 
    3440                 3445                 3450             


Arg Gln  His Gln Gly Ala Glu  His Pro Gln Pro His  Thr Leu Phe 
    3455                 3460                 3465             


Val Gly  Gly Leu Pro Ala Ser  Ser His Ser Ser Lys  Leu Pro Val 
    3470                 3475                 3480             


Thr Val  Gly Phe Ser Gly Cys  Val Lys Arg Leu Arg  Leu His Gly 
    3485                 3490                 3495             


Arg Pro  Leu Gly Ala Pro Thr  Arg Met Ala Gly Val  Thr Pro Cys 
    3500                 3505                 3510             


Ile Leu  Gly Pro Leu Glu Ala  Gly Leu Phe Phe Pro  Gly Ser Gly 
    3515                 3520                 3525             


Gly Val  Ile Thr Leu Asp Leu  Pro Gly Ala Thr Leu  Pro Asp Val 
    3530                 3535                 3540             


Gly Leu  Glu Leu Glu Val Arg  Pro Leu Ala Val Thr  Gly Leu Ile 
    3545                 3550                 3555             


Phe His  Leu Gly Gln Ala Arg  Thr Pro Pro Tyr Leu  Gln Leu Gln 
    3560                 3565                 3570             


Val Thr  Glu Lys Gln Val Leu  Leu Arg Ala Asp Asp  Gly Ala Gly 
    3575                 3580                 3585             


Glu Phe  Ser Thr Ser Val Thr  Arg Pro Ser Val Leu  Cys Asp Gly 
    3590                 3595                 3600             


Gln Trp  His Arg Leu Ala Val  Met Lys Ser Gly Asn  Val Leu Arg 
    3605                 3610                 3615             


Leu Glu  Val Asp Ala Gln Ser  Asn His Thr Val Gly  Pro Leu Leu 
    3620                 3625                 3630             


Ala Ala  Ala Ala Gly Ala Pro  Ala Pro Leu Tyr Leu  Gly Gly Leu 
    3635                 3640                 3645             


Pro Glu  Pro Met Ala Val Gln  Pro Trp Pro Pro Ala  Tyr Cys Gly 
    3650                 3655                 3660             


Cys Met  Arg Arg Leu Ala Val  Asn Arg Ser Pro Val  Ala Met Thr 
    3665                 3670                 3675             


Arg Ser  Val Glu Val His Gly  Ala Val Gly Ala Ser  Gly Cys Pro 
    3680                 3685                 3690             


Ala Ala  
    3695 


<210> 91
<211> 3333
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Ile Leu Leu Lys Gln  Ile Ser Gly 
    1940                 1945                 1950             


Thr Asp  Gly Glu Gly Asn Asn  Val Pro Ser Gly Asp  Phe Ser Arg 
    1955                 1960                 1965             


Glu Trp  Ala Glu Ala Gln Arg  Met Met Arg Glu Leu  Arg Asn Arg 
    1970                 1975                 1980             


Asn Phe  Gly Lys His Leu Arg  Glu Ala Glu Ala Asp  Lys Arg Glu 
    1985                 1990                 1995             


Ser Gln  Leu Leu Leu Asn Arg  Ile Arg Thr Trp Gln  Lys Thr His 
    2000                 2005                 2010             


Gln Gly  Glu Asn Asn Gly Leu  Ala Asn Ser Ile Arg  Asp Ser Leu 
    2015                 2020                 2025             


Asn Glu  Tyr Glu Ala Lys Leu  Ser Asp Leu Arg Ala  Arg Leu Gln 
    2030                 2035                 2040             


Glu Ala  Ala Ala Gln Ala Lys  Gln Ala Asn Gly Leu  Asn Gln Glu 
    2045                 2050                 2055             


Asn Glu  Arg Ala Leu Gly Ala  Ile Gln Arg Gln Val  Lys Glu Ile 
    2060                 2065                 2070             


Asn Ser  Leu Gln Ser Asp Phe  Thr Lys Tyr Leu Thr  Thr Ala Asp 
    2075                 2080                 2085             


Ser Ser  Leu Leu Gln Thr Asn  Ile Ala Leu Gln Leu  Met Glu Lys 
    2090                 2095                 2100             


Ser Gln  Lys Glu Tyr Glu Lys  Leu Ala Ala Ser Leu  Asn Glu Ala 
    2105                 2110                 2115             


Arg Gln  Glu Leu Ser Asp Lys  Val Arg Glu Leu Ser  Arg Ser Ala 
    2120                 2125                 2130             


Gly Lys  Thr Ser Leu Val Glu  Glu Ala Glu Lys His  Ala Arg Ser 
    2135                 2140                 2145             


Leu Gln  Glu Leu Ala Lys Gln  Leu Glu Glu Ile Lys  Arg Asn Ala 
    2150                 2155                 2160             


Ser Gly  Asp Glu Leu Val Arg  Cys Ala Val Asp Ala  Ala Thr Ala 
    2165                 2170                 2175             


Tyr Glu  Asn Ile Leu Asn Ala  Ile Lys Ala Ala Glu  Asp Ala Ala 
    2180                 2185                 2190             


Asn Arg  Ala Ala Ser Ala Ser  Glu Ser Ala Leu Gln  Thr Val Ile 
    2195                 2200                 2205             


Lys Glu  Asp Leu Pro Arg Lys  Ala Lys Thr Leu Ser  Ser Asn Ser 
    2210                 2215                 2220             


Asp Lys  Leu Leu Asn Glu Ala  Lys Met Thr Gln Lys  Lys Leu Lys 
    2225                 2230                 2235             


Gln Glu  Val Ser Pro Ala Leu  Asn Asn Leu Gln Gln  Thr Leu Asn 
    2240                 2245                 2250             


Ile Val  Thr Val Gln Lys Glu  Val Ile Asp Thr Asn  Leu Thr Thr 
    2255                 2260                 2265             


Leu Arg  Asp Gly Leu His Gly  Ile Gln Arg Gly Asp  Ile Asp Ala 
    2270                 2275                 2280             


Met Ile  Ser Ser Ala Lys Ser  Met Val Arg Lys Ala  Asn Asp Ile 
    2285                 2290                 2295             


Thr Asp  Glu Val Leu Asp Gly  Leu Asn Pro Ile Gln  Thr Asp Val 
    2300                 2305                 2310             


Glu Arg  Ile Lys Asp Thr Tyr  Gly Arg Thr Gln Asn  Glu Asp Phe 
    2315                 2320                 2325             


Lys Lys  Ala Leu Thr Asp Ala  Asp Asn Ser Val Asn  Lys Leu Thr 
    2330                 2335                 2340             


Asn Lys  Leu Pro Asp Leu Trp  Arg Lys Ile Glu Ser  Ile Asn Gln 
    2345                 2350                 2355             


Gln Leu  Leu Pro Leu Gly Asn  Ile Ser Asp Asn Met  Asp Arg Ile 
    2360                 2365                 2370             


Arg Glu  Leu Ile Gln Gln Ala  Arg Asp Ala Ala Ser  Lys Val Ala 
    2375                 2380                 2385             


Val Pro  Met Arg Phe Asn Gly  Lys Ser Gly Val Glu  Val Arg Leu 
    2390                 2395                 2400             


Pro Asn  Asp Leu Glu Asp Leu  Lys Gly Tyr Thr Ser  Leu Ser Leu 
    2405                 2410                 2415             


Phe Leu  Gln Arg Pro Asn Ser  Arg Glu Asn Gly Gly  Thr Glu Asn 
    2420                 2425                 2430             


Met Phe  Val Met Tyr Leu Gly  Asn Lys Asp Ala Ser  Arg Asp Tyr 
    2435                 2440                 2445             


Ile Gly  Met Ala Val Val Asp  Gly Gln Leu Thr Cys  Val Tyr Asn 
    2450                 2455                 2460             


Leu Gly  Asp Arg Glu Ala Glu  Leu Gln Val Asp Gln  Ile Leu Thr 
    2465                 2470                 2475             


Lys Ser  Glu Thr Lys Glu Ala  Val Met Asp Arg Val  Lys Phe Gln 
    2480                 2485                 2490             


Arg Ile  Tyr Gln Phe Ala Arg  Leu Asn Tyr Thr Lys  Gly Ala Thr 
    2495                 2500                 2505             


Ser Ser  Lys Pro Glu Thr Pro  Gly Val Tyr Asp Met  Asp Gly Arg 
    2510                 2515                 2520             


Asn Ser  Asn Thr Leu Leu Asn  Leu Asp Pro Glu Asn  Val Val Phe 
    2525                 2530                 2535             


Tyr Val  Gly Gly Tyr Pro Pro  Asp Phe Lys Leu Pro  Ser Arg Leu 
    2540                 2545                 2550             


Ser Phe  Pro Pro Tyr Lys Gly  Cys Ile Glu Leu Asp  Asp Leu Asn 
    2555                 2560                 2565             


Glu Asn  Val Leu Ser Leu Tyr  Asn Phe Lys Lys Thr  Phe Asn Leu 
    2570                 2575                 2580             


Asn Thr  Thr Glu Val Glu Pro  Cys Arg Arg Arg Lys  Glu Glu Ser 
    2585                 2590                 2595             


Asp Lys  Asn Tyr Phe Glu Gly  Thr Gly Tyr Ala Arg  Val Pro Thr 
    2600                 2605                 2610             


Gln Pro  His Ala Pro Ile Pro  Thr Phe Gly Gln Thr  Ile Gln Thr 
    2615                 2620                 2625             


Thr Val  Asp Arg Gly Leu Leu  Phe Phe Ala Glu Asn  Gly Asp Arg 
    2630                 2635                 2640             


Phe Ile  Ser Leu Asn Ile Glu  Asp Gly Lys Leu Met  Val Arg Tyr 
    2645                 2650                 2655             


Lys Leu  Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
    2660                 2665                 2670             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    2675                 2680                 2685             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    2690                 2695                 2700             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    2705                 2710                 2715             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    2720                 2725                 2730             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    2735                 2740                 2745             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    2750                 2755                 2760             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    2765                 2770                 2775             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    2780                 2785                 2790             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    2795                 2800                 2805             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    2810                 2815                 2820             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Ser Pro  Ile Phe Lys 
    2825                 2830                 2835             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    2840                 2845                 2850             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    2855                 2860                 2865             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    2870                 2875                 2880             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    2885                 2890                 2895             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    2900                 2905                 2910             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    2915                 2920                 2925             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    2930                 2935                 2940             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    2945                 2950                 2955             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    2960                 2965                 2970             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    2975                 2980                 2985             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    2990                 2995                 3000             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    3005                 3010                 3015             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    3020                 3025                 3030             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    3035                 3040                 3045             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    3050                 3055                 3060             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    3065                 3070                 3075             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    3080                 3085                 3090             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    3095                 3100                 3105             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    3110                 3115                 3120             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    3125                 3130                 3135             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    3140                 3145                 3150             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    3155                 3160                 3165             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    3170                 3175                 3180             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    3185                 3190                 3195             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    3200                 3205                 3210             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    3215                 3220                 3225             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    3230                 3235                 3240             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    3245                 3250                 3255             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    3260                 3265                 3270             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    3275                 3280                 3285             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    3290                 3295                 3300             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    3305                 3310                 3315             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    3320                 3325                 3330             


<210> 92
<211> 1575
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Ala Ala Ala Ala Leu Leu Leu Gly Leu Ala Leu Leu Ala Pro Arg 
1               5                   10                  15      


Ala Ala Gly Ala Gly Met Gly Ala Cys Tyr Asp Gly Ala Gly Arg Pro 
            20                  25                  30          


Gln Arg Cys Leu Pro Val Phe Glu Asn Ala Ala Phe Gly Arg Leu Ala 
        35                  40                  45              


Gln Ala Ser His Thr Cys Gly Ser Pro Pro Glu Asp Phe Cys Pro His 
    50                  55                  60                  


Val Gly Ala Ala Gly Ala Gly Ala His Cys Gln Arg Cys Asp Ala Ala 
65                  70                  75                  80  


Asp Pro Gln Arg His His Asn Ala Ser Tyr Leu Thr Asp Phe His Ser 
                85                  90                  95      


Gln Asp Glu Ser Thr Trp Trp Gln Ser Pro Ser Met Ala Phe Gly Val 
            100                 105                 110         


Gln Tyr Pro Thr Ser Val Asn Ile Thr Leu Arg Leu Gly Lys Ala Tyr 
        115                 120                 125             


Glu Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser 
    130                 135                 140                 


Phe Ala Ile Tyr Lys Arg Ser Arg Ala Asp Gly Pro Trp Glu Pro Tyr 
145                 150                 155                 160 


Gln Phe Tyr Ser Ala Ser Cys Gln Lys Thr Tyr Gly Arg Pro Glu Gly 
                165                 170                 175     


Gln Tyr Leu Arg Pro Gly Glu Asp Glu Arg Val Ala Phe Cys Thr Ser 
            180                 185                 190         


Glu Phe Ser Asp Ile Ser Pro Leu Ser Gly Gly Asn Val Ala Phe Ser 
        195                 200                 205             


Thr Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Glu Glu Ser Pro Gly 
    210                 215                 220                 


Leu Gln Glu Trp Val Thr Ser Thr Glu Leu Leu Ile Ser Leu Asp Arg 
225                 230                 235                 240 


Leu Asn Thr Phe Gly Asp Asp Ile Phe Lys Asp Pro Lys Val Leu Gln 
                245                 250                 255     


Ser Tyr Tyr Tyr Ala Val Ser Asp Phe Ser Val Gly Gly Arg Cys Lys 
            260                 265                 270         


Cys Asn Gly His Ala Ser Glu Cys Gly Pro Asp Val Ala Gly Gln Leu 
        275                 280                 285             


Ala Cys Arg Cys Gln His Asn Thr Thr Gly Thr Asp Cys Glu Arg Cys 
    290                 295                 300                 


Leu Pro Phe Phe Gln Asp Arg Pro Trp Ala Arg Gly Thr Ala Glu Ala 
305                 310                 315                 320 


Ala His Glu Cys Leu Pro Cys Asn Cys Ser Gly Arg Ser Glu Glu Cys 
                325                 330                 335     


Thr Phe Asp Arg Glu Leu Phe Arg Ser Thr Gly His Gly Gly Arg Cys 
            340                 345                 350         


His His Cys Arg Asp His Thr Ala Gly Pro His Cys Glu Arg Cys Gln 
        355                 360                 365             


Glu Asn Phe Tyr His Trp Asp Pro Arg Met Pro Cys Gln Pro Cys Asp 
    370                 375                 380                 


Cys Gln Ser Ala Gly Ser Leu His Leu Gln Cys Asp Asp Thr Gly Thr 
385                 390                 395                 400 


Cys Ala Cys Lys Pro Thr Val Thr Gly Trp Lys Cys Asp Arg Cys Leu 
                405                 410                 415     


Pro Gly Phe His Ser Leu Ser Glu Gly Gly Cys Arg Pro Cys Thr Cys 
            420                 425                 430         


Asn Pro Ala Gly Ser Leu Asp Thr Cys Asp Pro Arg Ser Gly Arg Cys 
        435                 440                 445             


Pro Cys Lys Glu Asn Val Glu Gly Asn Leu Cys Asp Arg Cys Arg Pro 
    450                 455                 460                 


Gly Thr Phe Asn Leu Gln Pro His Asn Pro Ala Gly Cys Ser Ser Cys 
465                 470                 475                 480 


Phe Cys Tyr Gly His Ser Lys Val Cys Ala Ser Thr Ala Gln Phe Gln 
                485                 490                 495     


Val His His Ile Leu Ser Asp Phe His Gln Gly Ala Glu Gly Trp Trp 
            500                 505                 510         


Ala Arg Ser Val Gly Gly Ser Glu His Pro Pro Gln Trp Ser Pro Asn 
        515                 520                 525             


Gly Val Leu Leu Ser Pro Glu Asp Glu Glu Glu Leu Thr Ala Pro Glu 
    530                 535                 540                 


Lys Phe Leu Gly Asp Gln Arg Phe Ser Tyr Gly Gln Pro Leu Ile Leu 
545                 550                 555                 560 


Thr Phe Arg Val Pro Pro Gly Asp Ser Pro Leu Pro Val Gln Leu Arg 
                565                 570                 575     


Leu Glu Gly Thr Gly Leu Ala Leu Ser Leu Arg His Ser Ser Leu Ser 
            580                 585                 590         


Gly Pro Gln Asp Ala Gly His Pro Arg Glu Val Glu Leu Arg Phe His 
        595                 600                 605             


Leu Gln Glu Thr Ser Glu Asp Val Ala Pro Pro Leu Pro Pro Phe His 
    610                 615                 620                 


Phe Gln Arg Leu Leu Ala Asn Leu Thr Ser Leu Arg Leu Arg Val Ser 
625                 630                 635                 640 


Pro Gly Pro Ser Pro Ala Gly Pro Val Phe Leu Thr Glu Val Arg Leu 
                645                 650                 655     


Thr Ser Ala Arg Pro Gly Leu Ser Pro Pro Ala Ser Trp Val Glu Ile 
            660                 665                 670         


Cys Ser Cys Pro Thr Gly Tyr Thr Gly Gln Phe Cys Glu Ser Cys Ala 
        675                 680                 685             


Pro Gly Tyr Lys Arg Glu Met Pro Gln Gly Gly Pro Tyr Ala Ser Cys 
    690                 695                 700                 


Val Pro Cys Thr Cys Asn Gln His Gly Thr Cys Asp Pro Asn Thr Gly 
705                 710                 715                 720 


Ile Cys Val Cys Ser His His Thr Glu Gly Pro Ser Cys Glu Arg Cys 
                725                 730                 735     


Leu Pro Gly Phe Tyr Gly Asn Pro Phe Ala Gly Gln Ala Asp Asp Cys 
            740                 745                 750         


Gln Pro Cys Pro Cys Pro Gly Gln Ser Ala Cys Thr Thr Ile Pro Glu 
        755                 760                 765             


Ser Arg Glu Val Val Cys Thr His Cys Pro Pro Gly Gln Arg Gly Arg 
    770                 775                 780                 


Arg Cys Glu Val Cys Asp Asp Gly Phe Phe Gly Asp Pro Leu Gly Leu 
785                 790                 795                 800 


Phe Gly His Pro Gln Pro Cys His Gln Cys Gln Cys Ser Gly Asn Val 
                805                 810                 815     


Asp Pro Asn Ala Val Gly Asn Cys Asp Pro Leu Ser Gly His Cys Leu 
            820                 825                 830         


Arg Cys Leu His Asn Thr Thr Gly Asp His Cys Glu His Cys Gln Glu 
        835                 840                 845             


Gly Phe Tyr Gly Ser Ala Leu Ala Pro Arg Pro Ala Asp Lys Cys Met 
    850                 855                 860                 


Pro Cys Ser Cys His Pro Gln Gly Ser Val Ser Glu Gln Met Pro Cys 
865                 870                 875                 880 


Asp Pro Val Thr Gly Gln Cys Ser Cys Leu Pro His Val Thr Ala Arg 
                885                 890                 895     


Asp Cys Ser Arg Cys Tyr Pro Gly Phe Phe Asp Leu Gln Pro Gly Arg 
            900                 905                 910         


Gly Cys Arg Ser Cys Lys Cys His Pro Leu Gly Ser Gln Glu Asp Gln 
        915                 920                 925             


Cys His Pro Lys Thr Gly Gln Cys Thr Cys Arg Pro Gly Val Thr Gly 
    930                 935                 940                 


Gln Ala Cys Asp Arg Cys Gln Leu Gly Phe Phe Gly Phe Ser Ile Lys 
945                 950                 955                 960 


Gly Cys Arg Ala Cys Arg Cys Ser Pro Leu Gly Ala Ala Ser Ala Gln 
                965                 970                 975     


Cys His Glu Asn Gly Thr Cys Val Cys Arg Pro Gly Phe Glu Gly Tyr 
            980                 985                 990         


Lys Cys Asp Arg Cys His Asp Asn  Phe Phe Leu Thr Ala  Asp Gly Thr 
        995                 1000                 1005             


His Cys  Gln Gln Cys Pro Ser  Cys Tyr Ala Leu Val  Lys Glu Glu 
    1010                 1015                 1020             


Ala Ala  Lys Leu Lys Ala Arg  Leu Thr Leu Thr Glu  Gly Trp Leu 
    1025                 1030                 1035             


Gln Gly  Ser Asp Cys Gly Ser  Pro Trp Gly Pro Leu  Asp Ile Leu 
    1040                 1045                 1050             


Leu Gly  Glu Ala Pro Arg Gly  Asp Val Tyr Gln Gly  His His Leu 
    1055                 1060                 1065             


Leu Pro  Gly Ala Arg Glu Ala  Phe Leu Glu Gln Met  Met Ser Leu 
    1070                 1075                 1080             


Glu Gly  Ala Val Lys Ala Ala  Arg Glu Gln Leu Gln  Arg Leu Asn 
    1085                 1090                 1095             


Lys Gly  Ala Arg Cys Ala Gln  Ala Gly Ser Gln Lys  Thr Cys Thr 
    1100                 1105                 1110             


Gln Leu  Ala Asp Leu Glu Ala  Val Leu Glu Ser Ser  Glu Glu Glu 
    1115                 1120                 1125             


Ile Leu  His Ala Ala Ala Ile  Leu Ala Ser Leu Glu  Ile Pro Gln 
    1130                 1135                 1140             


Glu Gly  Pro Ser Gln Pro Thr  Lys Trp Ser His Leu  Ala Thr Glu 
    1145                 1150                 1155             


Ala Arg  Ala Leu Ala Arg Ser  His Arg Asp Thr Ala  Thr Lys Ile 
    1160                 1165                 1170             


Ala Ala  Thr Ala Trp Arg Ala  Leu Leu Ala Ser Asn  Thr Ser Tyr 
    1175                 1180                 1185             


Ala Leu  Leu Trp Asn Leu Leu  Glu Gly Arg Val Ala  Leu Glu Thr 
    1190                 1195                 1200             


Gln Arg  Asp Leu Glu Asp Arg  Tyr Gln Glu Val Gln  Ala Ala Gln 
    1205                 1210                 1215             


Lys Ala  Leu Arg Thr Ala Val  Ala Glu Val Leu Pro  Glu Ala Glu 
    1220                 1225                 1230             


Ser Val  Leu Ala Thr Val Gln  Gln Val Gly Ala Asp  Thr Ala Pro 
    1235                 1240                 1245             


Tyr Leu  Ala Leu Leu Ala Ser  Pro Gly Ala Leu Pro  Gln Lys Ser 
    1250                 1255                 1260             


Arg Ala  Glu Asp Leu Gly Leu  Lys Ala Lys Ala Leu  Glu Lys Thr 
    1265                 1270                 1275             


Val Ala  Ser Trp Gln His Met  Ala Thr Glu Ala Ala  Arg Thr Leu 
    1280                 1285                 1290             


Gln Thr  Ala Ala Gln Ala Thr  Leu Arg Gln Thr Glu  Pro Leu Thr 
    1295                 1300                 1305             


Lys Leu  His Gln Glu Ala Arg  Ala Ala Leu Thr Gln  Ala Ser Ser 
    1310                 1315                 1320             


Ser Val  Gln Ala Ala Thr Val  Thr Val Met Gly Ala  Arg Thr Leu 
    1325                 1330                 1335             


Leu Ala  Asp Leu Glu Gly Met  Lys Leu Gln Phe Pro  Arg Pro Lys 
    1340                 1345                 1350             


Asp Gln  Ala Ala Leu Gln Arg  Lys Ala Asp Ser Val  Ser Asp Arg 
    1355                 1360                 1365             


Leu Leu  Ala Asp Thr Arg Lys  Lys Thr Lys Gln Ala  Glu Arg Met 
    1370                 1375                 1380             


Leu Gly  Asn Ala Ala Pro Leu  Ser Ser Ser Ala Lys  Lys Lys Gly 
    1385                 1390                 1395             


Arg Glu  Ala Glu Val Leu Ala  Lys Asp Ser Ala Lys  Leu Ala Lys 
    1400                 1405                 1410             


Ala Leu  Leu Arg Glu Arg Lys  Gln Ala His Arg Arg  Ala Ser Arg 
    1415                 1420                 1425             


Leu Thr  Ser Gln Thr Gln Ala  Thr Leu Gln Gln Ala  Ser Gln Gln 
    1430                 1435                 1440             


Val Leu  Ala Ser Glu Ala Arg  Arg Gln Glu Leu Glu  Glu Ala Glu 
    1445                 1450                 1455             


Arg Val  Gly Ala Gly Leu Ser  Glu Met Glu Gln Gln  Ile Arg Glu 
    1460                 1465                 1470             


Ser Arg  Ile Ser Leu Glu Lys  Asp Ile Glu Thr Leu  Ser Glu Leu 
    1475                 1480                 1485             


Leu Ala  Arg Leu Gly Ser Leu  Asp Thr His Gln Ala  Pro Ala Gln 
    1490                 1495                 1500             


Ala Leu  Asn Glu Thr Gln Trp  Ala Leu Glu Arg Leu  Arg Leu Gln 
    1505                 1510                 1515             


Leu Gly  Ser Pro Gly Ser Leu  Gln Arg Lys Leu Ser  Leu Leu Glu 
    1520                 1525                 1530             


Gln Glu  Ser Gln Gln Gln Glu  Leu Gln Ile Gln Gly  Phe Glu Ser 
    1535                 1540                 1545             


Asp Leu  Ala Glu Ile Arg Ala  Asp Lys Gln Asn Leu  Glu Ala Ile 
    1550                 1555                 1560             


Leu His  Ser Leu Pro Glu Asn  Cys Ala Ser Trp Gln  
    1565                 1570                 1575 


<210> 93
<211> 1823
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Ala Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys 
                325                 330                 335     


Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp 
            340                 345                 350         


Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln 
        355                 360                 365             


Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu 
    370                 375                 380                 


Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn 
385                 390                 395                 400 


Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile 
                405                 410                 415     


Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser 
            420                 425                 430         


Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp 
        435                 440                 445             


Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His 
    450                 455                 460                 


Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp 
465                 470                 475                 480 


Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu 
                485                 490                 495     


Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg 
            500                 505                 510         


Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu 
        515                 520                 525             


Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro 
    530                 535                 540                 


Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly 
545                 550                 555                 560 


Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu 
                565                 570                 575     


Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp 
            580                 585                 590         


His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu 
        595                 600                 605             


His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser 
    610                 615                 620                 


Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr 
625                 630                 635                 640 


Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser 
                645                 650                 655     


Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu 
            660                 665                 670         


Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp 
        675                 680                 685             


Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg 
    690                 695                 700                 


Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln 
705                 710                 715                 720 


Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu 
                725                 730                 735     


Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr 
            740                 745                 750         


Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His 
        755                 760                 765             


Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala 
    770                 775                 780                 


Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg 
785                 790                 795                 800 


Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln 
                805                 810                 815     


Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile 
            820                 825                 830         


Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser 
        835                 840                 845             


Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr 
    850                 855                 860                 


Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln 
865                 870                 875                 880 


Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly 
                885                 890                 895     


Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr 
            900                 905                 910         


Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro 
        915                 920                 925             


Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys 
    930                 935                 940                 


Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe 
945                 950                 955                 960 


Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp 
                965                 970                 975     


Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Thr Ser Leu Asn Leu Pro  Gly Phe Val Gly Cys  Leu Glu Leu 
        995                 1000                 1005             


Ala Thr  Leu Asn Asn Asp Val  Ile Ser Leu Tyr Asn  Phe Lys His 
    1010                 1015                 1020             


Ile Tyr  Asn Met Asp Pro Ser  Thr Ser Val Pro Cys  Ala Arg Asp 
    1025                 1030                 1035             


Lys Leu  Ala Phe Thr Gln Ser  Arg Ala Ala Ser Tyr  Phe Phe Asp 
    1040                 1045                 1050             


Gly Ser  Gly Tyr Ala Val Val  Arg Asp Ile Thr Arg  Arg Gly Lys 
    1055                 1060                 1065             


Phe Gly  Gln Val Thr Arg Phe  Asp Ile Glu Val Arg  Thr Pro Ala 
    1070                 1075                 1080             


Asp Asn  Gly Leu Ile Leu Leu  Met Val Asn Gly Ser  Met Phe Phe 
    1085                 1090                 1095             


Arg Leu  Glu Met Arg Asn Gly  Tyr Leu His Val Phe  Tyr Asp Phe 
    1100                 1105                 1110             


Gly Phe  Ser Gly Gly Pro Val  His Leu Glu Asp Thr  Leu Lys Lys 
    1115                 1120                 1125             


Ala Gln  Ile Asn Asp Ala Lys  Tyr His Glu Ile Ser  Ile Ile Tyr 
    1130                 1135                 1140             


His Asn  Asp Lys Lys Met Ile  Leu Val Val Asp Arg  Arg His Val 
    1145                 1150                 1155             


Lys Ser  Met Asp Asn Glu Lys  Met Lys Ile Pro Phe  Thr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Gly Gly Ala Pro Pro  Glu Ile Leu Gln Ser  Arg Ala Leu 
    1175                 1180                 1185             


Arg Ala  His Leu Pro Leu Asp  Ile Asn Phe Arg Gly  Cys Met Lys 
    1190                 1195                 1200             


Gly Phe  Gln Phe Gln Lys Lys  Asp Phe Asn Leu Leu  Glu Gln Thr 
    1205                 1210                 1215             


Glu Thr  Leu Gly Val Gly Tyr  Gly Cys Pro Glu Asp  Ser Leu Ile 
    1220                 1225                 1230             


Ser Arg  Arg Ala Tyr Phe Asn  Gly Gln Ser Phe Ile  Ala Ser Ile 
    1235                 1240                 1245             


Gln Lys  Ile Ser Phe Phe Asp  Gly Phe Glu Gly Gly  Phe Asn Phe 
    1250                 1255                 1260             


Arg Thr  Leu Gln Pro Asn Gly  Leu Leu Phe Tyr Tyr  Ala Ser Gly 
    1265                 1270                 1275             


Ser Asp  Val Phe Ser Ile Ser  Leu Asp Asn Gly Thr  Val Ile Met 
    1280                 1285                 1290             


Asp Val  Lys Gly Ile Lys Val  Gln Ser Val Asp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Asp Gly  Leu Ser His Phe Val  Ile Ser Ser Val Ser  Pro Thr Arg 
    1310                 1315                 1320             


Tyr Glu  Leu Ile Val Asp Lys  Ser Arg Val Gly Ser  Lys Asn Pro 
    1325                 1330                 1335             


Thr Lys  Gly Lys Ile Glu Gln  Thr Gln Ala Ser Glu  Lys Lys Phe 
    1340                 1345                 1350             


Tyr Phe  Gly Gly Ser Pro Ile  Ser Ala Gln Tyr Ala  Asn Phe Thr 
    1355                 1360                 1365             


Gly Cys  Ile Ser Asn Ala Tyr  Phe Thr Arg Val Asp  Arg Asp Val 
    1370                 1375                 1380             


Glu Val  Glu Asp Phe Gln Arg  Tyr Thr Glu Lys Val  His Thr Ser 
    1385                 1390                 1395             


Leu Tyr  Glu Cys Pro Ile Glu  Ser Ser Pro Leu Phe  Leu Leu His 
    1400                 1405                 1410             


Lys Lys  Gly Lys Asn Leu Ser  Lys Pro Lys Ala Ser  Gln Asn Lys 
    1415                 1420                 1425             


Lys Gly  Gly Lys Ser Lys Asp  Ala Pro Ser Trp Asp  Pro Val Ala 
    1430                 1435                 1440             


Leu Lys  Leu Pro Glu Arg Asn  Thr Pro Arg Asn Ser  His Cys His 
    1445                 1450                 1455             


Leu Ser  Asn Ser Pro Arg Ala  Ile Glu His Ala Tyr  Gln Tyr Gly 
    1460                 1465                 1470             


Gly Thr  Ala Asn Ser Arg Gln  Glu Phe Glu His Leu  Lys Gly Asp 
    1475                 1480                 1485             


Phe Gly  Ala Lys Ser Gln Phe  Ser Ile Arg Leu Arg  Thr Arg Ser 
    1490                 1495                 1500             


Ser His  Gly Met Ile Phe Tyr  Val Ser Asp Gln Glu  Glu Asn Asp 
    1505                 1510                 1515             


Phe Met  Thr Leu Phe Leu Ala  His Gly Arg Leu Val  Tyr Met Phe 
    1520                 1525                 1530             


Asn Val  Gly His Lys Lys Leu  Lys Ile Arg Ser Gln  Glu Lys Tyr 
    1535                 1540                 1545             


Asn Asp  Gly Leu Trp His Asp  Val Ile Phe Ile Arg  Glu Arg Ser 
    1550                 1555                 1560             


Ser Gly  Arg Leu Val Ile Asp  Gly Leu Arg Val Leu  Glu Glu Ser 
    1565                 1570                 1575             


Leu Pro  Pro Thr Glu Ala Thr  Trp Lys Ile Lys Gly  Pro Ile Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Val Ala Pro Gly  Lys Ala Val Lys Asn  Val Gln Ile 
    1595                 1600                 1605             


Asn Ser  Ile Tyr Ser Phe Ser  Gly Cys Leu Ser Asn  Leu Gln Leu 
    1610                 1615                 1620             


Asn Gly  Ala Ser Ile Thr Ser  Ala Ser Gln Thr Phe  Ser Val Thr 
    1625                 1630                 1635             


Pro Cys  Phe Glu Gly Pro Met  Glu Thr Gly Thr Tyr  Phe Ser Thr 
    1640                 1645                 1650             


Glu Gly  Gly Tyr Val Val Leu  Asp Glu Ser Phe Asn  Ile Gly Leu 
    1655                 1660                 1665             


Lys Phe  Glu Ile Ala Phe Glu  Val Arg Pro Arg Ser  Ser Ser Gly 
    1670                 1675                 1680             


Thr Leu  Val His Gly His Ser  Val Asn Gly Glu Tyr  Leu Asn Val 
    1685                 1690                 1695             


His Met  Lys Asn Gly Gln Val  Ile Val Lys Val Asn  Asn Gly Ile 
    1700                 1705                 1710             


Arg Asp  Phe Ser Thr Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp 
    1715                 1720                 1725             


Gly Arg  Trp His Arg Ile Thr  Val Ile Arg Asp Ser  Asn Val Val 
    1730                 1735                 1740             


Gln Leu  Asp Val Asp Ser Glu  Val Asn His Val Val  Gly Pro Leu 
    1745                 1750                 1755             


Asn Pro  Lys Pro Ile Asp His  Arg Glu Pro Val Phe  Val Gly Gly 
    1760                 1765                 1770             


Val Pro  Glu Ser Leu Leu Thr  Pro Arg Leu Ala Pro  Ser Lys Pro 
    1775                 1780                 1785             


Phe Thr  Gly Cys Ile Arg His  Phe Val Ile Asp Gly  His Pro Val 
    1790                 1795                 1800             


Ser Phe  Ser Lys Ala Ala Leu  Val Ser Gly Ala Val  Ser Ile Asn 
    1805                 1810                 1815             


Ser Cys  Pro Ala Ala 
    1820             


<210> 94
<211> 1193
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210> 95
<211> 1172
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210> 96
<211> 1761
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Met Gln Phe Gln Leu Thr Leu Phe Leu His Leu Gly Trp Leu Ser Tyr 
1               5                   10                  15      


Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr Thr 
            20                  25                  30          


Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser Thr 
        35                  40                  45              


Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu Glu 
    50                  55                  60                  


Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp Pro 
65                  70                  75                  80  


Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser Phe 
                85                  90                  95      


Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu Asp 
            100                 105                 110         


His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser His 
        115                 120                 125             


Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu 
    130                 135                 140                 


Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe Ala 
145                 150                 155                 160 


Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala Gln 
                165                 170                 175     


Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu Pro 
            180                 185                 190         


Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe Glu 
        195                 200                 205             


Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu Thr 
    210                 215                 220                 


Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala Leu 
225                 230                 235                 240 


Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala Leu 
                245                 250                 255     


Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala Ser 
            260                 265                 270         


Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro Pro 
        275                 280                 285             


Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly Pro 
    290                 295                 300                 


Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn Ser 
                325                 330                 335     


His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser Gly 
            340                 345                 350         


Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu Lys 
    370                 375                 380                 


Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro Asp 
385                 390                 395                 400 


Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala Leu 
                405                 410                 415     


Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly Ala 
            420                 425                 430         


Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr Asp 
        435                 440                 445             


Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu Pro 
    450                 455                 460                 


Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser Tyr 
465                 470                 475                 480 


Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly Leu 
                485                 490                 495     


Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly Gly 
            500                 505                 510         


Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys Arg 
        515                 520                 525             


Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr Phe 
    530                 535                 540                 


Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr Thr 
545                 550                 555                 560 


Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser Pro 
                565                 570                 575     


Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val Thr 
            580                 585                 590         


Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu Arg 
        595                 600                 605             


Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala Ile 
    610                 615                 620                 


His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val Val 
625                 630                 635                 640 


Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln Ser 
                645                 650                 655     


Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu Leu 
            660                 665                 670         


Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp Val 
        675                 680                 685             


Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His Val 
    690                 695                 700                 


Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile Asn Ser Leu Glu Asn 
705                 710                 715                 720 


Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln Leu His Asn Cys Val 
                725                 730                 735     


Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu Pro Gly Ala Cys Glu 
            740                 745                 750         


Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His Asp Gly Ala Val Ala 
        755                 760                 765             


Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg Leu 
    770                 775                 780                 


Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys Asp 
785                 790                 795                 800 


Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His Pro 
                805                 810                 815     


Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln Val 
            820                 825                 830         


Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys Asp 
        835                 840                 845             


Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys Pro 
    850                 855                 860                 


Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys Phe 
865                 870                 875                 880 


Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile Asp 
                885                 890                 895     


Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys Leu 
            900                 905                 910         


Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys Tyr 
        915                 920                 925             


Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly Tyr 
    930                 935                 940                 


Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn Pro 
945                 950                 955                 960 


Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn Ile 
                965                 970                 975     


Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys Leu 
            980                 985                 990         


Arg Cys Leu His Asn Thr Gln Gly  Ala Asn Cys Gln Leu  Cys Lys Pro 
        995                 1000                 1005             


Gly His  Tyr Gly Ser Ala Leu  Asn Gln Thr Cys Arg  Arg Cys Ser 
    1010                 1015                 1020             


Cys His  Ala Ser Gly Val Ser  Pro Met Glu Cys Pro  Pro Gly Gly 
    1025                 1030                 1035             


Gly Ala  Cys Leu Cys Asp Pro  Val Thr Gly Ala Cys  Pro Cys Leu 
    1040                 1045                 1050             


Pro Asn  Val Thr Gly Leu Ala  Cys Asp Arg Cys Ala  Asp Gly Tyr 
    1055                 1060                 1065             


Trp Asn  Leu Val Pro Gly Arg  Gly Cys Gln Ser Cys  Asp Cys Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ser Gln Ser Ser  His Cys Asp Gln Leu  Thr Gly Gln 
    1085                 1090                 1095             


Cys Pro  Cys Lys Leu Gly Tyr  Gly Gly Lys Arg Cys  Ser Glu Cys 
    1100                 1105                 1110             


Gln Glu  Asn Tyr Tyr Gly Asp  Pro Pro Gly Arg Cys  Ile Pro Cys 
    1115                 1120                 1125             


Asp Cys  Asn Arg Ala Gly Thr  Gln Lys Pro Ile Cys  Asp Pro Asp 
    1130                 1135                 1140             


Thr Gly  Met Cys Arg Cys Arg  Glu Gly Val Ser Gly  Gln Arg Cys 
    1145                 1150                 1155             


Asp Arg  Cys Ala Arg Gly His  Ser Gln Glu Phe Pro  Thr Cys Leu 
    1160                 1165                 1170             


Gln Cys  His Leu Cys Phe Asp  Gln Trp Asp His Thr  Ile Ser Ser 
    1175                 1180                 1185             


Leu Ser  Lys Ala Val Gln Gly  Leu Met Arg Leu Ala  Ala Asn Met 
    1190                 1195                 1200             


Glu Asp  Lys Arg Glu Thr Leu  Pro Val Cys Glu Ala  Asp Phe Lys 
    1205                 1210                 1215             


Asp Leu  Arg Gly Asn Val Ser  Glu Ile Glu Arg Ile  Leu Lys His 
    1220                 1225                 1230             


Pro Val  Phe Pro Ser Gly Lys  Phe Leu Lys Val Lys  Asp Tyr His 
    1235                 1240                 1245             


Asp Ser  Val Arg Arg Gln Ile  Met Gln Leu Asn Glu  Gln Leu Lys 
    1250                 1255                 1260             


Ala Val  Tyr Glu Phe Gln Asp  Leu Lys Asp Thr Ile  Glu Arg Ala 
    1265                 1270                 1275             


Lys Asn  Glu Ala Asp Leu Leu  Leu Glu Asp Leu Gln  Glu Glu Ile 
    1280                 1285                 1290             


Asp Leu  Gln Ser Ser Val Leu  Asn Ala Ser Ile Ala  Asp Ser Ser 
    1295                 1300                 1305             


Glu Asn  Ile Lys Lys Tyr Tyr  His Ile Ser Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys Ile  Asn Glu Thr Ser Ser  Thr Ile Asn Thr Ser  Ala Asn Thr 
    1325                 1330                 1335             


Arg Asn  Asp Leu Leu Thr Ile  Leu Asp Thr Leu Thr  Ser Lys Gly 
    1340                 1345                 1350             


Asn Leu  Ser Leu Glu Arg Leu  Lys Gln Ile Lys Ile  Pro Asp Ile 
    1355                 1360                 1365             


Gln Ile  Leu Asn Glu Lys Val  Cys Gly Asp Pro Gly  Asn Val Pro 
    1370                 1375                 1380             


Cys Val  Pro Leu Pro Cys Gly  Gly Ala Leu Cys Thr  Gly Arg Lys 
    1385                 1390                 1395             


Gly His  Arg Lys Cys Arg Gly  Pro Gly Cys His Gly  Ser Leu Thr 
    1400                 1405                 1410             


Leu Ser  Thr Asn Ala Leu Gln  Lys Ala Gln Glu Ala  Lys Ser Ile 
    1415                 1420                 1425             


Ile Arg  Asn Leu Asp Lys Gln  Val Arg Gly Leu Lys  Asn Gln Ile 
    1430                 1435                 1440             


Glu Ser  Ile Ser Glu Gln Ala  Glu Val Ser Lys Asn  Asn Ala Leu 
    1445                 1450                 1455             


Gln Leu  Arg Glu Lys Leu Gly  Asn Ile Arg Asn Gln  Ser Asp Ser 
    1460                 1465                 1470             


Glu Glu  Glu Asn Ile Asn Leu  Phe Ile Lys Lys Val  Lys Asn Phe 
    1475                 1480                 1485             


Leu Leu  Glu Glu Asn Val Pro  Pro Glu Asp Ile Glu  Lys Val Ala 
    1490                 1495                 1500             


Asn Gly  Val Leu Asp Ile His  Leu Pro Ile Pro Ser  Gln Asn Leu 
    1505                 1510                 1515             


Thr Asp  Glu Leu Val Lys Ile  Gln Lys His Met Gln  Leu Cys Glu 
    1520                 1525                 1530             


Asp Tyr  Arg Thr Asp Glu Asn  Arg Leu Asn Glu Glu  Ala Asp Gly 
    1535                 1540                 1545             


Ala Gln  Lys Leu Leu Val Lys  Ala Lys Ala Ala Glu  Lys Ala Ala 
    1550                 1555                 1560             


Asn Ile  Leu Leu Asn Leu Asp  Lys Thr Leu Asn Gln  Leu Gln Gln 
    1565                 1570                 1575             


Ala Gln  Ile Thr Gln Gly Arg  Ala Asn Ser Thr Ile  Thr Gln Leu 
    1580                 1585                 1590             


Thr Ala  Asn Ile Thr Lys Ile  Lys Lys Asn Val Leu  Gln Ala Glu 
    1595                 1600                 1605             


Asn Gln  Thr Arg Glu Met Lys  Ser Glu Leu Glu Leu  Ala Lys Gln 
    1610                 1615                 1620             


Arg Ser  Gly Leu Glu Asp Gly  Leu Ser Leu Leu Gln  Thr Lys Leu 
    1625                 1630                 1635             


Gln Arg  His Gln Asp His Ala  Val Asn Ala Lys Val  Gln Ala Glu 
    1640                 1645                 1650             


Ser Ala  Gln His Gln Ala Gly  Ser Leu Glu Lys Glu  Phe Val Glu 
    1655                 1660                 1665             


Leu Lys  Lys Gln Tyr Ala Ile  Leu Gln Arg Lys Thr  Ser Thr Thr 
    1670                 1675                 1680             


Gly Leu  Thr Lys Glu Thr Leu  Gly Lys Val Lys Gln  Leu Lys Asp 
    1685                 1690                 1695             


Ala Ala  Glu Lys Leu Ala Gly  Asp Thr Glu Ala Lys  Ile Arg Arg 
    1700                 1705                 1710             


Ile Thr  Asp Leu Glu Arg Lys  Ile Gln Asp Leu Asn  Leu Ser Arg 
    1715                 1720                 1725             


Gln Ala  Lys Ala Asp Gln Leu  Arg Ile Leu Glu Asp  Gln Val Val 
    1730                 1735                 1740             


Ala Ile  Lys Asn Glu Ile Val  Glu Gln Glu Lys Lys  Tyr Ala Arg 
    1745                 1750                 1755             


Cys Tyr  Ser 
    1760     


<210> 97
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Met Ile Ala Ser Gln Phe Leu Ser Ala Leu Thr Leu Val Leu Leu Ile 
1               5                   10                  15      


Lys Glu Ser Gly Ala Trp Ser Tyr Asn Thr Ser Thr Glu Ala Met Thr 
            20                  25                  30          


Tyr Asp Glu Ala Ser Ala Tyr Cys Gln Gln Arg Tyr Thr His Leu Val 
        35                  40                  45              


Ala Ile Gln Asn Lys Glu Glu Ile Glu Tyr Leu Asn Ser Ile Leu Ser 
    50                  55                  60                  


Tyr Ser Pro Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Val Asn Asn Val 
65                  70                  75                  80  


Trp Val Trp Val Gly Thr Gln Lys Pro Leu Thr Glu Glu Ala Lys Asn 
                85                  90                  95      


Trp Ala Pro Gly Glu Pro Asn Asn Arg Gln Lys Asp Glu Asp Cys Val 
            100                 105                 110         


Glu Ile Tyr Ile Lys Arg Glu Lys Asp Val Gly Met Trp Asn Asp Glu 
        115                 120                 125             


Arg Cys Ser Lys Lys Lys Leu Ala Leu Cys Tyr Thr Ala Ala Cys Thr 
    130                 135                 140                 


Asn Thr Ser Cys Ser Gly His Gly Glu Cys Val Glu Thr Ile Asn Asn 
145                 150                 155                 160 


Tyr Thr Cys Lys Cys Asp Pro Gly Phe Ser Gly Leu Lys Cys Glu Gln 
                165                 170                 175     


Ile Val Asn Cys Thr Ala Leu Glu Ser Pro Glu His Gly Ser Leu Val 
            180                 185                 190         


Cys Ser His Pro Leu Gly Asn Phe Ser Tyr Asn Ser Ser Cys Ser Ile 
        195                 200                 205             


Ser Cys Asp Arg Gly Tyr Leu Pro Ser Ser Met Glu Thr Met Gln Cys 
    210                 215                 220                 


Met Ser Ser Gly Glu Trp Ser Ala Pro Ile Pro Ala Cys Asn Val Val 
225                 230                 235                 240 


Glu Cys Asp Ala Val Thr Asn Pro Ala Asn Gly Phe Val Glu Cys Phe 
                245                 250                 255     


Gln Asn Pro Gly Ser Phe Pro Trp Asn Thr Thr Cys Thr Phe Asp Cys 
            260                 265                 270         


Glu Glu Gly Phe Glu Leu Met Gly Ala Gln Ser Leu Gln Cys Thr Ser 
        275                 280                 285             


Ser Gly Asn Trp Asp Asn Glu Lys Pro Thr Cys Lys Ala Val Thr Cys 
    290                 295                 300                 


Arg Ala Val Arg Gln Pro Gln Asn Gly Ser Val Arg Cys Ser His Ser 
305                 310                 315                 320 


Pro Ala Gly Glu Phe Thr Phe Lys Ser Ser Cys Asn Phe Thr Cys Glu 
                325                 330                 335     


Glu Gly Phe Met Leu Gln Gly Pro Ala Gln Val Glu Cys Thr Thr Gln 
            340                 345                 350         


Gly Gln Trp Thr Gln Gln Ile Pro Val Cys Glu Ala Phe Gln Cys Thr 
        355                 360                 365             


Ala Leu Ser Asn Pro Glu Arg Gly Tyr Met Asn Cys Leu Pro Ser Ala 
    370                 375                 380                 


Ser Gly Ser Phe Arg Tyr Gly Ser Ser Cys Glu Phe Ser Cys Glu Gln 
385                 390                 395                 400 


Gly Phe Val Leu Lys Gly Ser Lys Arg Leu Gln Cys Gly Pro Thr Gly 
                405                 410                 415     


Glu Trp Asp Asn Glu Lys Pro Thr Cys Glu Ala Val Arg Cys Asp Ala 
            420                 425                 430         


Val His Gln Pro Pro Lys Gly Leu Val Arg Cys Ala His Ser Pro Ile 
        435                 440                 445             


Gly Glu Phe Thr Tyr Lys Ser Ser Cys Ala Phe Ser Cys Glu Glu Gly 
    450                 455                 460                 


Phe Glu Leu His Gly Ser Thr Gln Leu Glu Cys Thr Ser Gln Gly Gln 
465                 470                 475                 480 


Trp Thr Glu Glu Val Pro Ser Cys Gln Val Val Lys Cys Ser Ser Leu 
                485                 490                 495     


Ala Val Pro Gly Lys Ile Asn Met Ser Cys Ser Gly Glu Pro Val Phe 
            500                 505                 510         


Gly Thr Val Cys Lys Phe Ala Cys Pro Glu Gly Trp Thr Leu Asn Gly 
        515                 520                 525             


Ser Ala Ala Arg Thr Cys Gly Ala Thr Gly His Trp Ser Gly Leu Leu 
    530                 535                 540                 


Pro Thr Cys Glu Ala Pro Thr Glu Ser Asn Ile Pro Leu Val Ala Gly 
545                 550                 555                 560 


Leu Ser Ala Ala Gly Leu Ser Leu Leu Thr Leu Ala Pro Phe Leu Leu 
                565                 570                 575     


Trp Leu Arg Lys Cys Leu Arg Lys Ala Lys Lys Phe Val Pro Ala Ser 
            580                 585                 590         


Ser Cys Gln Ser Leu Glu Ser Asp Gly Ser Tyr Gln Lys Pro Ser Tyr 
        595                 600                 605             


Ile Leu 
    610 


<210> 98
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val 
1               5                   10                  15      


Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu 
            20                  25                  30          


Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser Thr 
        35                  40                  45              


Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr 
    50                  55                  60                  


Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn 
65                  70                  75                  80  


Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys 
                85                  90                  95      


Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn 
            100                 105                 110         


Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn 
        115                 120                 125             


Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys 
    130                 135                 140                 


Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr 
145                 150                 155                 160 


Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu 
                165                 170                 175     


Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro 
            180                 185                 190         


Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His 
        195                 200                 205             


Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser 
    210                 215                 220                 


Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser 
225                 230                 235                 240 


Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln 
                245                 250                 255     


Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn 
            260                 265                 270         


Met Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys 
        275                 280                 285             


Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val 
    290                 295                 300                 


Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys 
305                 310                 315                 320 


Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp 
                325                 330                 335     


Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe 
            340                 345                 350         


Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys 
        355                 360                 365             


Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile 
    370                 375                 380                 


Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser 
385                 390                 395                 400 


Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys 
                405                 410                 415     


Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn 
            420                 425                 430         


Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys 
        435                 440                 445             


Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro 
    450                 455                 460                 


Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu 
465                 470                 475                 480 


Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly 
                485                 490                 495     


Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro 
            500                 505                 510         


Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly 
        515                 520                 525             


Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr 
    530                 535                 540                 


Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp 
545                 550                 555                 560 


Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe 
                565                 570                 575     


Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe 
            580                 585                 590         


Asn Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys Leu 
        595                 600                 605             


Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala 
    610                 615                 620                 


Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Leu 
625                 630                 635                 640 


Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg 
                645                 650                 655     


His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys 
            660                 665                 670         


Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro 
        675                 680                 685             


Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys 
    690                 695                 700                 


Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu 
705                 710                 715                 720 


Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu 
                725                 730                 735     


Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly 
            740                 745                 750         


His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile 
        755                 760                 765             


Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly 
    770                 775                 780                 


Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg 
785                 790                 795                 800 


Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly 
                805                 810                 815     


Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro 
            820                 825                 830 


<210> 99
<211> 184
<212> PRT
<213> Homo sapiens

<400> 99
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Ala Lys 
            100                 105                 110         


Pro Thr Val Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr 
        115                 120                 125             


Ser Gly Thr Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg 
    130                 135                 140                 


Lys Ser Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val 
145                 150                 155                 160 


Leu Gly Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser 
                165                 170                 175     


Lys Glu Arg Asn Tyr His Thr Leu 
            180                 


<210> 100
<211> 178
<212> PRT
<213> Homo sapiens

<400> 100
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Gly Thr Thr Asn Asn 
        115                 120                 125             


Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr Phe Asp Ala 
    130                 135                 140                 


Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala Val 
145                 150                 155                 160 


Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His 
                165                 170                 175     


Thr Leu 
        


<210> 101
<211> 189
<212> PRT
<213> Homo sapiens

<400> 101
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Glu Ile 
                165                 170                 175     


Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
            180                 185                 


<210> 102
<211> 157
<212> PRT
<213> Homo sapiens

<400> 102
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Glu Ile 
    130                 135                 140                 


Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
145                 150                 155         


<210> 103
<211> 163
<212> PRT
<213> Homo sapiens

<400> 103
Met Arg Lys Gly Arg Lys Val Pro Met Tyr Val Pro Gly Val Leu Arg 
1               5                   10                  15      


Thr Tyr Pro Lys Ala Lys Leu Glu Glu Thr Cys Glu Gly Arg Asn Ser 
            20                  25                  30          


Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys Phe Trp 
        35                  40                  45              


Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr Val Ser 
    50                  55                  60                  


Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser Thr Ala 
65                  70                  75                  80  


Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val Gln Pro 
                85                  90                  95      


Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr Thr Asn 
            100                 105                 110         


Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr Phe Asp 
        115                 120                 125             


Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala 
    130                 135                 140                 


Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr 
145                 150                 155                 160 


His Thr Leu 
            


<210> 104
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210> 105
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210> 106
<211> 423
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Met Glu Gly Ile Ser Glu Asn Ala Pro Leu Pro Asn Val Pro Asn Ala 
1               5                   10                  15      


Pro Ser Asp Lys His Glu Asp Gly Lys Arg Pro Thr His Arg Arg Ser 
            20                  25                  30          


Ala Arg Leu Gly Glu Glu Val Pro Phe Val His Phe Leu Thr Leu Pro 
        35                  40                  45              


Pro Asn Ile Pro Gln Ala Pro Lys Gly Leu Arg Phe Lys Thr Ala Phe 
    50                  55                  60                  


Ser Leu Pro Thr Thr Ser Cys Leu Lys Pro Arg Met Ile Tyr Thr Ser 
65                  70                  75                  80  


Asp Asn Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys 
                85                  90                  95      


Glu Pro Cys Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu 
            100                 105                 110         


Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly 
        115                 120                 125             


Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr 
    130                 135                 140                 


Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile 
145                 150                 155                 160 


Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly 
                165                 170                 175     


Asn Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr 
            180                 185                 190         


Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala 
        195                 200                 205             


Ile Val His Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu 
    210                 215                 220                 


Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile 
225                 230                 235                 240 


Pro Asp Phe Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile 
                245                 250                 255     


Cys Asp Arg Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe 
            260                 265                 270         


Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser 
        275                 280                 285             


Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln 
    290                 295                 300                 


Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe 
305                 310                 315                 320 


Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile 
                325                 330                 335     


Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His 
            340                 345                 350         


Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu 
        355                 360                 365             


Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala 
    370                 375                 380                 


Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu 
385                 390                 395                 400 


Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu 
                405                 410                 415     


Ser Ser Ser Phe His Ser Ser 
            420             


<210> 107
<211> 385
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Met Glu Gly Ile Ser Glu Asn Ala Pro Leu Pro Asn Val Pro Asn Ala 
1               5                   10                  15      


Pro Ser Asp Lys His Glu Asp Gly Lys Arg Pro Thr His Arg Arg Ser 
            20                  25                  30          


Ala Arg Leu Gly Glu Glu Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu 
        35                  40                  45              


Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu 
    50                  55                  60                  


Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile 
65                  70                  75                  80  


Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met 
                85                  90                  95      


Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His 
            100                 105                 110         


Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala 
        115                 120                 125             


Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala 
    130                 135                 140                 


Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu 
145                 150                 155                 160 


Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn 
                165                 170                 175     


Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly 
            180                 185                 190         


Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala 
        195                 200                 205             


Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro 
    210                 215                 220                 


Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly 
225                 230                 235                 240 


Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile 
                245                 250                 255     


Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys 
            260                 265                 270         


Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr 
        275                 280                 285             


Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys 
    290                 295                 300                 


Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr 
305                 310                 315                 320 


Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala 
                325                 330                 335     


Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser 
            340                 345                 350         


Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly 
        355                 360                 365             


Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser 
    370                 375                 380                 


Ser 
385 


<210> 108
<211> 337
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu 
1               5                   10                  15      


Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile 
            20                  25                  30          


Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met 
        35                  40                  45              


Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His 
    50                  55                  60                  


Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala 
65                  70                  75                  80  


Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala 
                85                  90                  95      


Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu 
            100                 105                 110         


Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn 
        115                 120                 125             


Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly 
    130                 135                 140                 


Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala 
145                 150                 155                 160 


Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro 
                165                 170                 175     


Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly 
            180                 185                 190         


Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile 
        195                 200                 205             


Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys 
    210                 215                 220                 


Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr 
225                 230                 235                 240 


Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys 
                245                 250                 255     


Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr 
            260                 265                 270         


Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala 
        275                 280                 285             


Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser 
    290                 295                 300                 


Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly 
305                 310                 315                 320 


Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser 
                325                 330                 335     


Ser 
    


<210> 109
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Insulin degrading enzyme motif

<400> 109
Glu Lys Pro Pro His Tyr 
1               5       


