                         SEQUENCE LISTING

<110>  	Janssen Biotech, Inc.
	Goldberg, Steven
	Kummer, David
	Keith, John
	Woods, Craig
	Rhorer, Timonthy
	Tanis, Virginia
	Martin, Connor
	Meduna, Steven
	Xue, Xiaohua
	McCarver, Stefan
	Loskot, Steven
	Valdes, Alexander
 
<120>  IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17

<130>  716604: NTT-6306PC 

<140>
<141>

<150>  63/017,682
<151>  2020-04-30

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  182
<212>  PRT
<213>  artificial

<220>
<223>  Human IL17A with a FLAg tag

<400>  1

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gly Ser Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Gly Ser Gly Ser Gly Ser Leu Glu Val Leu Phe Gln 
        35                  40                  45              


Gly Pro Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu 
    50                  55                  60                  


Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn 
65                  70                  75                  80  


Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg 
                85                  90                  95      


Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr 
            100                 105                 110         


Pro Ser Val Ile Trp Glu Ala Gln Cys Arg His Leu Gly Cys Ile Asn 
        115                 120                 125             


Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln 
    130                 135                 140                 


Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe 
145                 150                 155                 160 


Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro 
                165                 170                 175     


Ile Val His His Val Gln 
            180         


<210>  2
<211>  323
<212>  PRT
<213>  artificial

<220>
<223>  IL17A with a His tag

<400>  2

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys 
            20                  25                  30          


Ser Gln Pro Gly Leu Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp 
        35                  40                  45              


Asp Ser Trp Ile His Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp 
    50                  55                  60                  


Leu Gln Ile Gln Leu His Phe Ala His Thr Gln Gln Gly Asp Leu Phe 
65                  70                  75                  80  


Pro Val Ala His Ile Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu 
                85                  90                  95      


Tyr Leu Glu Gly Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu 
            100                 105                 110         


Arg Leu Cys Val Arg Phe Glu Phe Leu Ser Lys Leu Arg His His His 
        115                 120                 125             


Arg Arg Trp Arg Phe Thr Phe Ser His Phe Val Val Asp Pro Asp Gln 
    130                 135                 140                 


Glu Tyr Glu Val Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly 
145                 150                 155                 160 


Asp Pro Asn His Gln Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His 
                165                 170                 175     


Ala Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp 
            180                 185                 190         


Asp Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val 
        195                 200                 205             


Ser Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr 
    210                 215                 220                 


Ser Phe Pro His Met Glu Asn His Ser Cys Phe Glu His Met His His 
225                 230                 235                 240 


Ile Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr 
                245                 250                 255     


Leu Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile 
            260                 265                 270         


Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala 
        275                 280                 285             


Thr Val Ser Cys Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp 
    290                 295                 300                 


Tyr Met Pro Leu Trp Gly Ser Gly Gly His His His His His His His 
305                 310                 315                 320 


His His His 
            


