                         SEQUENCE LISTING

<110>  BicycleTx Limited
 
<120>  ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS

<130>  BIC-C-P2806PCT

<150>  63/025,552
<151>  2020-05-15

<150>  63/135,213
<151>  2021-01-08

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  1

Cys His Lys Phe Pro Cys Arg Asp Pro Gln Gln Tyr Leu Phe Cys 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  2

Cys Thr Ser Pro Met Cys Tyr Val Leu Lys His Gln Asn Arg Cys 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  3

Cys Thr Arg Pro Trp Cys His Ser Leu Leu Pro Arg Ala Thr Cys 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  4

Cys Gly Arg Gln Phe Cys His Thr Leu Met Pro Arg His Leu Cys 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  5

Cys Val Arg Ser His Cys Ser Ser Leu Leu Pro Arg Ile His Cys 
1               5                   10                  15  


<210>  6
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  6

Cys Gly Arg Glu Glu Leu Pro Cys Arg Ile Lys Leu Cys 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  7

Cys Leu Arg Ser Tyr Asn Leu Cys Pro Arg Ile Asn Cys 
1               5                   10              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  8

Cys His Arg Asp Phe Pro Arg Cys Thr Trp Glu Thr Gln Trp Cys 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  9

Cys Ala Pro Ile Leu Cys Arg Trp Ala Glu Arg Gln Gly Tyr Cys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  10

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is 1Nal

<400>  11

Cys Asn Ala Val Leu Cys Ser Xaa Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is 2Nal

<400>  12

Cys Asn Ala Val Leu Cys Ser Xaa Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is Aib

<400>  13

Cys Asn Ala Val Leu Cys Ser Trp Xaa Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  14

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  15

Cys Leu Glu Leu Tyr Gln Cys Trp Arg Gly Lys Cys 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  16

Cys Pro Ser Gln Tyr Lys Cys Trp Arg Gly Lys Cys 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  17

Cys Leu Glu Val Tyr Lys Cys Trp Arg Gly Lys Cys 
1               5                   10          


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is Aib

<400>  18

Cys Ala Asn Xaa Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15      


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is Arg(Me)

<400>  19

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  20

Cys Asn Lys Val Leu Cys Ser Trp Ala Ser Arg Asn Ser Met Cys 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  21

Cys Asn Gln Val Leu Cys Arg Trp Ala Gln Val Asn Ser Met Cys 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  22

Cys Asn Arg Val Leu Cys Ala Trp Ala Thr Ala Asn Ser Met Cys 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  23

Cys Asn Thr Val Leu Cys Asn Trp Ala Arg Tyr Asn Ser Leu Cys 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  24

Cys Asn Thr Val Leu Cys Ala Trp Ala Arg Ala Asn Ser Tyr Cys 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  25

Cys Asn Thr Val Leu Cys Gly Trp Ala Arg Ala Asn Ser Leu Cys 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  26

Cys Asn Thr Val Leu Cys Ala Trp Ala Met Asn Asn Ser Met Cys 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  27

Cys Asn Thr Val Leu Cys Ala Trp Ala Thr Gln Asn Ser Leu Cys 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  28

Cys Ser Pro Val Leu Cys Ala Trp Ala Thr Arg Asn Ser Leu Cys 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is tBuGly

<400>  29

Cys Asn Ala Xaa Leu Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is tBuAla

<400>  30

Cys Asn Ala Xaa Leu Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is tBuGly

<400>  31

Cys Asn Ala Val Xaa Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is tBuAla

<400>  32

Cys Asn Ala Val Xaa Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is Cba

<400>  33

Cys Asn Ala Val Xaa Cys Ser Trp Ala Arg Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 2MePhe

<400>  34

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 3MePhe

<400>  35

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 4MePhe

<400>  36

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 2ClPhe

<400>  37

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 3ClPhe

<400>  38

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 4ClPhe

<400>  39

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 2FPhe

<400>  40

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is 3FPhe

<400>  41

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is Agb

<400>  42

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  43

Cys Asn Ala Val Leu Cys Ser Trp Ala Arg Ala Asn Ser Tyr Cys 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HyP

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  44

Cys Asn Xaa Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  45

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  46

Cys Asn Asp Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  47

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Hse(Me)

<400>  48

Cys Asn Arg Val Leu Cys Ala Trp Ala Thr Ala Asn Ser Xaa Cys 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  49

Cys Asn Xaa Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  50

Cys Asn Thr Val Leu Cys Gly Trp Ala Xaa Ala Asn Ser Leu Cys 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  51

Cys Asn Thr Val Leu Cys Gly Trp Ala Arg Ala Asn Ser Leu Cys 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  52

Cys Asn Thr Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  53

Cys Asn Ser Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  54

Cys Asn Asp Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  55

Cys Asn Glu Val Leu Cys Ser Trp Ala Xaa Ala Asn Ser Phe Cys 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa is HyP

<400>  56

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Xaa Asn Ser Phe Cys 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  57

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Thr Asn Ser Phe Cys 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  58

Cys Asn Ala Val Leu Cys Ser Trp Ala Xaa Ser Asn Ser Phe Cys 
1               5                   10                  15  


<210>  59
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  59

Cys Ala Glu Ile Tyr Lys Cys Trp Arg Gly Arg Cys 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  60

Cys Asp Thr Leu Tyr Lys Cys Trp Arg Gly Arg Cys 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  61

Cys Glu Ser Leu Tyr Lys Cys Trp Arg Gly Arg Cys 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  62

Cys Asn Thr Leu Tyr Lys Cys Trp Arg Gly Lys Cys 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  63

Cys Thr Glu Leu Tyr Lys Cys Trp Arg Gly Arg Cys 
1               5                   10          


