                         SEQUENCE LISTING

<110>  Greffex
 
<120>  Engineering Coronavirus Spike Proteins as Vaccine Antigens, Their
        Design and Uses

<130>  543346.15

<150>  US 63/023599
<151>  2020-05-12

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  SARS-CoV

<400>  1

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  2
<211>  1256
<212>  PRT
<213>  SARSr

<400>  2

Met Lys Leu Leu Val Leu Val Phe Ala Thr Leu Val Ser Ser Tyr Thr 
1               5                   10                  15      


Ile Glu Lys Cys Leu Asp Phe Asp Asp Arg Thr Pro Pro Ala Asn Thr 
            20                  25                  30          


Gln Phe Leu Ser Ser His Arg Gly Val Tyr Tyr Pro Asp Asp Ile Phe 
        35                  40                  45              


Arg Ser Asn Val Leu His Leu Val Gln Asp His Phe Leu Pro Phe Asp 
    50                  55                  60                  


Ser Asn Val Thr Arg Phe Ile Thr Phe Gly Leu Asn Phe Asp Asn Pro 
65                  70                  75                  80  


Ile Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser 
                85                  90                  95      


Asn Val Ile Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser 
            100                 105                 110         


Gln Ser Val Ile Ile Met Asn Asn Ser Thr Asn Leu Val Ile Arg Ala 
        115                 120                 125             


Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Val Val Leu Lys Ser 
    130                 135                 140                 


Asn Asn Thr Gln Ile Pro Ser Tyr Ile Phe Asn Asn Ala Phe Asn Cys 
145                 150                 155                 160 


Thr Phe Glu Tyr Val Ser Lys Asp Phe Asn Leu Asp Leu Gly Glu Lys 
                165                 170                 175     


Pro Gly Asn Phe Lys Asp Leu Arg Glu Phe Val Phe Arg Asn Lys Asp 
            180                 185                 190         


Gly Phe Leu His Val Tyr Ser Gly Tyr Gln Pro Ile Ser Ala Ala Ser 
        195                 200                 205             


Gly Leu Pro Thr Gly Phe Asn Ala Leu Lys Pro Ile Phe Lys Leu Pro 
    210                 215                 220                 


Leu Gly Ile Asn Ile Thr Asn Phe Arg Thr Leu Leu Thr Ala Phe Pro 
225                 230                 235                 240 


Pro Arg Pro Asp Tyr Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly 
                245                 250                 255     


Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys 
        275                 280                 285             


Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Ala Pro Ser Lys Glu Val Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Thr Phe Pro 
                325                 330                 335     


Ser Val Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr 
            420                 425                 430         


Gln Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Ser Leu Arg His Gly Lys 
        435                 440                 445             


Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp 
    450                 455                 460                 


Gly Lys Pro Cys Thr Pro Pro Ala Phe Asn Cys Tyr Trp Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr Gly Phe Tyr Ile Thr Asn Gly Ile Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys 
    530                 535                 540                 


Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr 
545                 550                 555                 560 


Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Ser Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr His Thr Val Ser Ser Leu Arg Ser Thr Ser Gln 
            660                 665                 670         


Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile 
        675                 680                 685             


Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser 
    690                 695                 700                 


Ile Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp 
705                 710                 715                 720 


Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu 
                725                 730                 735     


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly 
            740                 745                 750         


Ile Ala Val Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val 
        755                 760                 765             


Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys Asp Phe Gly Gly Phe Asn 
    770                 775                 780                 


Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe 
785                 790                 795                 800 


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
                805                 810                 815     


Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu 
            820                 825                 830         


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
        835                 840                 845             


Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr 
    850                 855                 860                 


Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
865                 870                 875                 880 


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
                885                 890                 895     


Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys 
            900                 905                 910         


Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu 
        915                 920                 925             


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
    930                 935                 940                 


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
945                 950                 955                 960 


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile 
                965                 970                 975     


Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr 
            980                 985                 990         


Gln Gln Leu Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
        995                 1000                 1005             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1010                 1015                 1020             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala 
    1025                 1030                 1035             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ser 
    1040                 1045                 1050             


Gln Glu  Arg Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly 
    1055                 1060                 1065             


Lys Ala  Tyr Phe Pro Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr 
    1070                 1075                 1080             


Ser Trp  Phe Ile Thr Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile 
    1085                 1090                 1095             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Ser Cys Asp  Val Val Ile 
    1100                 1105                 1110             


Gly Ile  Ile Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1115                 1120                 1125             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1130                 1135                 1140             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1145                 1150                 1155             


Val Val  Asn Ile Gln Lys Glu  Ile Asn Arg Leu Asn  Glu Val Ala 
    1160                 1165                 1170             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1175                 1180                 1185             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe 
    1190                 1195                 1200             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Leu Leu Cys 
    1205                 1210                 1215             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Ala  Cys Ser Cys 
    1220                 1225                 1230             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1235                 1240                 1245             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255     


<210>  3
<211>  1241
<212>  PRT
<213>  SARS

<400>  3

Met Lys Ile Leu Ile Phe Ala Phe Leu Val Thr Leu Val Lys Ala Gln 
1               5                   10                  15      


Glu Gly Cys Gly Leu Ile Ser Arg Lys Pro Gln Pro Lys Met Ala Gln 
            20                  25                  30          


Val Ser Ser Ser Arg Arg Gly Val Tyr Tyr Asn Asp Asp Ile Phe Arg 
        35                  40                  45              


Ser Asp Val Leu His Leu Thr Gln Asp Tyr Phe Leu Pro Phe Asp Ser 
    50                  55                  60                  


Asn Leu Thr Gln Tyr Phe Ser Leu Asn Val Asp Ser Asp Arg Tyr Thr 
65                  70                  75                  80  


Tyr Phe Asp Asn Pro Ile Leu Asp Phe Gly Asp Gly Val Tyr Phe Ala 
                85                  90                  95      


Ala Thr Glu Lys Ser Asn Val Ile Arg Gly Trp Ile Phe Gly Ser Thr 
            100                 105                 110         


Phe Asp Asn Thr Thr Gln Ser Ala Val Ile Val Asn Asn Ser Thr His 
        115                 120                 125             


Ile Ile Ile Arg Val Cys Asn Phe Asn Leu Cys Lys Glu Pro Met Tyr 
    130                 135                 140                 


Thr Val Ser Arg Gly Thr Gln Gln Ser Ser Trp Val Tyr Gln Ser Ala 
145                 150                 155                 160 


Phe Asn Cys Thr Tyr Asp Arg Val Glu Arg Ser Phe Gln Leu Asp Thr 
                165                 170                 175     


Ala Pro Lys Thr Gly Asn Phe Lys Asp Leu Arg Glu Tyr Val Phe Lys 
            180                 185                 190         


Asn Arg Asp Gly Phe Leu Ser Val Tyr Gln Thr Tyr Thr Ala Val Asn 
        195                 200                 205             


Leu Pro Arg Gly Leu Pro Thr Gly Phe Ser Val Leu Arg Pro Ile Leu 
    210                 215                 220                 


Lys Leu Pro Phe Gly Ile Asn Ile Thr Ser Tyr Arg Val Val Met Ala 
225                 230                 235                 240 


Met Phe Ser Gln Thr Thr Ser Asn Phe Leu Pro Glu Ser Ala Ala Tyr 
                245                 250                 255     


Tyr Val Gly Asn Leu Lys Tyr Thr Thr Phe Met Leu Ser Phe Asn Glu 
            260                 265                 270         


Asn Gly Thr Ile Thr Asp Ala Ile Asp Cys Ala Gln Asn Pro Leu Ala 
        275                 280                 285             


Glu Leu Lys Cys Thr Ile Lys Asn Phe Asn Val Ser Lys Gly Ile Tyr 
    290                 295                 300                 


Gln Thr Ser Asn Phe Arg Val Ser Pro Thr Gln Glu Val Ile Arg Phe 
305                 310                 315                 320 


Pro Asn Ile Thr Asn Arg Cys Pro Phe Asp Lys Val Phe Asn Ala Ser 
                325                 330                 335     


Arg Phe Pro Asn Val Tyr Ala Trp Glu Arg Thr Lys Ile Ser Asp Cys 
            340                 345                 350         


Val Ala Asp Tyr Thr Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe 
        355                 360                 365             


Lys Cys Tyr Gly Val Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr 
    370                 375                 380                 


Ser Val Tyr Ala Asp Thr Phe Leu Ile Arg Ser Ser Glu Val Arg Gln 
385                 390                 395                 400 


Val Ala Pro Gly Glu Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu 
                405                 410                 415     


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln 
            420                 425                 430         


Asp Gln Gly Gln Tyr Tyr Tyr Arg Ser Ser Arg Lys Thr Lys Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Leu Ser Ser Asp Glu Asn Gly Val Arg Thr Leu 
    450                 455                 460                 


Ser Thr Tyr Asp Phe Tyr Pro Thr Val Pro Ile Glu Tyr Gln Ala Thr 
465                 470                 475                 480 


Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val 
                485                 490                 495     


Cys Gly Pro Lys Leu Ser Thr Gly Leu Val Lys Asn Gln Cys Val Asn 
            500                 505                 510         


Phe Asn Phe Asn Gly Leu Lys Gly Thr Gly Val Leu Thr Asp Ser Ser 
        515                 520                 525             


Lys Arg Phe Gln Ser Phe Gln Gln Phe Gly Arg Asp Met Ser Asp Phe 
    530                 535                 540                 


Thr Asp Ser Val Arg Asp Pro Gln Thr Leu Gln Ile Leu Asp Ile Thr 
545                 550                 555                 560 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala 
                565                 570                 575     


Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val 
            580                 585                 590         


Pro Thr Ala Ile Arg Ala Asp Gln Leu Thr Pro Ala Trp Arg Val Tyr 
        595                 600                 605             


Ser Thr Gly Ile Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly 
    610                 615                 620                 


Ala Glu His Val Asn Ala Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
625                 630                 635                 640 


Gly Ile Cys Ala Ser Tyr His Thr Ala Ser Thr Leu Arg Ser Val Gly 
                645                 650                 655     


Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
            660                 665                 670         


Ile Ala Tyr Ala Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Ser Ile 
        675                 680                 685             


Ser Val Thr Thr Glu Val Met Pro Val Ser Met Ser Lys Thr Ser Val 
    690                 695                 700                 


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Gln Glu Cys Ser Asn Leu 
705                 710                 715                 720 


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
                725                 730                 735     


Gly Ile Ala Ile Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
            740                 745                 750         


Val Lys Gln Met Tyr Lys Thr Pro Ala Ile Lys Asp Phe Gly Gly Phe 
        755                 760                 765             


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Thr Lys Arg Ser 
    770                 775                 780                 


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
785                 790                 795                 800 


Phe Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp 
                805                 810                 815     


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
            820                 825                 830         


Leu Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly 
        835                 840                 845             


Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
    850                 855                 860                 


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
865                 870                 875                 880 


Gln Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn 
                885                 890                 895     


Lys Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala 
            900                 905                 910         


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
        915                 920                 925             


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
    930                 935                 940                 


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
945                 950                 955                 960 


Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
                965                 970                 975     


Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
            980                 985                 990         


Ala Ala Thr Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
        995                 1000                 1005             


Asp Phe  Cys Gly Arg Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala 
    1010                 1015                 1020             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ser 
    1025                 1030                 1035             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly 
    1040                 1045                 1050             


Lys Ala  Tyr Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1055                 1060                 1065             


Ser Trp  Phe Ile Thr Gln Arg  Asn Phe Tyr Ser Pro  Gln Ile Ile 
    1070                 1075                 1080             


Thr Thr  Asp Asn Thr Phe Val  Ala Gly Asn Cys Asp  Val Val Ile 
    1085                 1090                 1095             


Gly Ile  Ile Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1100                 1105                 1110             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1115                 1120                 1125             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1130                 1135                 1140             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1145                 1150                 1155             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1160                 1165                 1170             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe 
    1175                 1180                 1185             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Ala Thr Ile  Leu Leu Cys 
    1190                 1195                 1200             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Ala  Cys Ser Cys 
    1205                 1210                 1215             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1220                 1225                 1230             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1235                 1240     


<210>  4
<211>  1246
<212>  PRT
<213>  SARS

<400>  4

Met Leu Phe Phe Leu Phe Leu Gln Phe Ala Leu Val Asn Ser Gln Cys 
1               5                   10                  15      


Val Asn Leu Thr Gly Arg Thr Pro Leu Asn Pro Asn Tyr Thr Asn Ser 
            20                  25                  30          


Ser Gln Arg Gly Val Tyr Tyr Pro Asp Thr Ile Tyr Arg Ser Asp Thr 
        35                  40                  45              


Leu Val Leu Ser Gln Gly Tyr Phe Leu Pro Phe Tyr Ser Asn Val Ser 
    50                  55                  60                  


Trp Tyr Tyr Ser Leu Thr Thr Asn Asn Ala Ala Thr Lys Arg Thr Asp 
65                  70                  75                  80  


Asn Pro Ile Leu Asp Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu 
                85                  90                  95      


His Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Asn 
            100                 105                 110         


Thr Ser Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Ile Ile 
        115                 120                 125             


Lys Val Cys Asn Phe Asp Phe Cys Tyr Asp Pro Tyr Leu Ser Gly Tyr 
    130                 135                 140                 


Tyr His Asn Asn Lys Thr Trp Ser Ile Arg Glu Phe Ala Val Tyr Ser 
145                 150                 155                 160 


Ser Tyr Ala Asn Cys Thr Phe Glu Tyr Val Ser Lys Ser Phe Met Leu 
                165                 170                 175     


Asn Ile Ser Gly Asn Gly Gly Leu Phe Asn Thr Leu Arg Glu Phe Val 
            180                 185                 190         


Phe Arg Asn Val Asp Gly His Phe Lys Ile Tyr Ser Lys Phe Thr Pro 
        195                 200                 205             


Val Asn Leu Asn Arg Gly Leu Pro Thr Gly Leu Ser Val Leu Gln Pro 
    210                 215                 220                 


Leu Val Glu Leu Pro Val Ser Ile Asn Ile Thr Lys Phe Arg Thr Leu 
225                 230                 235                 240 


Leu Thr Ile His Arg Gly Asp Pro Met Pro Asn Asn Gly Trp Thr Ala 
                245                 250                 255     


Phe Ser Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Arg Thr Phe Met 
            260                 265                 270         


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
        275                 280                 285             


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Leu Thr Val 
    290                 295                 300                 


Gln Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Gln 
305                 310                 315                 320 


Ser Val Val Arg Phe Pro Asn Ile Thr Asn Val Cys Pro Phe His Lys 
                325                 330                 335     


Val Phe Asn Ala Thr Arg Phe Pro Ser Val Tyr Ala Trp Glu Arg Thr 
            340                 345                 350         


Lys Ile Ser Asp Cys Ile Ala Asp Tyr Thr Val Phe Tyr Asn Ser Thr 
        355                 360                 365             


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Ser Lys Leu Ile 
    370                 375                 380                 


Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp Thr Phe Leu Ile Arg Phe 
385                 390                 395                 400 


Ser Glu Val Arg Gln Val Ala Pro Gly Gln Thr Gly Val Ile Ala Asp 
                405                 410                 415     


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
            420                 425                 430         


Asn Thr Ala Lys Gln Asp Val Gly Asn Tyr Phe Tyr Arg Ser His Arg 
        435                 440                 445             


Ser Thr Lys Leu Lys Pro Phe Glu Arg Asp Leu Ser Ser Asp Glu Asn 
    450                 455                 460                 


Gly Val Arg Thr Leu Ser Thr Tyr Asp Phe Asn Pro Asn Val Pro Leu 
465                 470                 475                 480 


Glu Tyr Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn 
                485                 490                 495     


Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Gln Leu Val Lys 
            500                 505                 510         


Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Lys Gly Thr Gly Val 
        515                 520                 525             


Leu Thr Asp Ser Ser Lys Arg Phe Gln Ser Phe Gln Gln Phe Gly Lys 
    530                 535                 540                 


Asp Ala Ser Asp Phe Ile Asp Ser Val Arg Asp Pro Gln Thr Leu Glu 
545                 550                 555                 560 


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
                565                 570                 575     


Pro Gly Thr Asn Thr Ser Leu Glu Val Ala Val Leu Tyr Gln Asp Val 
            580                 585                 590         


Asn Cys Thr Asp Val Pro Thr Thr Ile His Ala Asp Gln Leu Thr Pro 
        595                 600                 605             


Ala Trp Arg Ile Tyr Ala Thr Gly Thr Asn Val Phe Gln Thr Gln Ala 
    610                 615                 620                 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Ala Ser Tyr Glu Cys Asp 
625                 630                 635                 640 


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His Thr Ala Ser Ile 
                645                 650                 655     


Leu Arg Ser Thr Ser Gln Lys Ala Ile Val Ala Tyr Thr Met Ser Leu 
            660                 665                 670         


Gly Ala Glu Asn Ser Ile Ala Tyr Ala Asn Asn Ser Ile Ala Ile Pro 
        675                 680                 685             


Thr Asn Phe Ser Ile Ser Val Thr Thr Glu Val Met Pro Val Ser Met 
    690                 695                 700                 


Ala Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Ile 
705                 710                 715                 720 


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
                725                 730                 735     


Asn Arg Ala Leu Ser Gly Ile Ala Ile Glu Gln Asp Lys Asn Thr Gln 
            740                 745                 750         


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
        755                 760                 765             


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
    770                 775                 780                 


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
785                 790                 795                 800 


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Gly 
                805                 810                 815     


Ile Ser Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
            820                 825                 830         


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Ala Tyr Thr Ala 
        835                 840                 845             


Ala Leu Ile Ser Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly 
    850                 855                 860                 


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
865                 870                 875                 880 


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
                885                 890                 895     


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Glu Ser Leu Thr 
            900                 905                 910         


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
        915                 920                 925             


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
    930                 935                 940                 


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
945                 950                 955                 960 


Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
                965                 970                 975     


Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg 
            980                 985                 990         


Ala Ser Ala Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
        995                 1000                 1005             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1010                 1015                 1020             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1025                 1030                 1035             


Thr Tyr  Ile Pro Ser Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1040                 1045                 1050             


Ile Cys  His Glu Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1055                 1060                 1065             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1070                 1075                 1080             


Glu Pro  Lys Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1085                 1090                 1095             


Cys Asp  Val Val Ile Gly Ile  Ile Asn Asn Thr Val  Tyr Asp Pro 
    1100                 1105                 1110             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1115                 1120                 1125             


Phe Lys  Asn His Thr Ser Pro  Asp Ile Asp Leu Gly  Asp Ile Ser 
    1130                 1135                 1140             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1145                 1150                 1155             


Leu Asn  Glu Val Ala Arg Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1160                 1165                 1170             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1175                 1180                 1185             


Val Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1190                 1195                 1200             


Thr Ile  Leu Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1205                 1210                 1215             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1220                 1225                 1230             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr 
    1235                 1240                 1245     


<210>  5
<211>  1273
<212>  PRT
<213>  SARS-CoV-2

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


